Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_ALL GO:0030334~regulation of cell migration 9 1.27% 0.00493180190262478 GAB1, LAMA1, TIE1, PLG, EGFR, PARD6B, ITGB3, LAMA3, CDK5, 674 61 15360 3.3623583207666488 0.9999999999947657 0.08456236628210878 9.024326339029953 GOTERM_BP_ALL GO:0006461~protein complex assembly 41 5.81% 1.8799910334824146E-10 ACTN2, BCL10, LIN7A, SRC, MDM4, IGF1R, PARD6B, CREBBP, TJP1, WIPF1, SMAD4, DLG4, IKBKAP, MPP6, GJA1, PPARGC1A, APC2, TP53, SLC9A3R1, PTK2, TRAF1, NCK1, APBA1, MBD2, CHAF1A, CD74, DAG1, PICK1, PXN, MDM2, CHAF1B, CAV1, FANCA, SMAD3, KIFAP3, HCFC1, PARD3, SLC9A3R2, ADRB2, CLTCL1, MAGI1, 674 295 15360 3.1673288739123873 9.877465775298688E-7 1.411067229728502E-8 3.5963936273475383E-7 GOTERM_BP_ALL GO:0030324~lung development 10 1.42% 2.816606276732298E-4 CTNNB1, FGFR1, WNT2, GLI1, MMP14, FGF2, MAP3K7IP1, EP300, BMPR1A, FGF1, 674 50 15360 4.55786350148368 0.7723744634939185 0.007639341150467938 0.5374390222525505 GOTERM_BP_ALL GO:0030323~respiratory tube development 10 1.42% 3.2892410781967346E-4 CTNNB1, FGFR1, WNT2, GLI1, MMP14, FGF2, MAP3K7IP1, EP300, BMPR1A, FGF1, 674 51 15360 4.468493628905568 0.8224408600533479 0.008779860249859328 0.6273542201295057 GOTERM_BP_ALL GO:0045449~regulation of transcription 178 25.21% 2.330199562677095E-10 MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, HMGB1, NRF1, RYBP, CIITA, IKBKAP, CDK2, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, NOTCH1, SMAD1, HCFC1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, ASCC2, SAFB, IFI16, NRIP1, ORC2L, TP73, DNM2, AR, CARM1, ERCC2, HOXB9, CCNT1, RELB, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PAX3, DACH1, FABP4, SMAD3, IL4, SREBF2, TCF4, RUNX1T1, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, EDA2R, NEUROD1, MYF5, SMARCA4, FZD1, PPARG, RHOH, TRIP4, HOXC8, NPM1, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, TCEA2, PPARGC1A, HCLS1, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, PYCARD, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, ASCL1, PAX2, SOX10, WT1, NCOA2, 674 2598 15360 1.5613928084374424 1.224285998024932E-6 1.7243475203265746E-8 4.4576361490911154E-7 GOTERM_BP_ALL GO:0001816~cytokine production 16 2.27% 2.607240956317975E-4 CD28, BCL10, TRAF6, LCP2, ELA2, CADM1, PYCARD, IL27RA, CEBPE, IL12A, REL, EBI3, STAT5A, FABP4, IL4, MAP3K7, 674 121 15360 3.0134634720553257 0.7458988861654459 0.007110138989189108 0.49758421492278604 GOTERM_BP_ALL GO:0016569~covalent chromatin modification 8 1.13% 0.0036262852120275413 RNF2, PCGF2, PPARGC1A, SMARCA4, EP300, HDAC1, CREBBP, CARM1, 674 46 15360 3.963359566507547 0.9999999948647184 0.06705380595582966 6.713648165505914 GOTERM_BP_ALL GO:0009893~positive regulation of metabolic process 64 9.07% 7.678429067300469E-17 CD28, BCL10, GATA4, HNF4A, FHL2, CREBBP, REL, NEUROD1, PPARG, EGFR, PRKCG, NR5A1, SMAD4, NOTCH4, CDK2, PPARGC1A, POU1F1, HSP90AA1, HCLS1, ELA2, PPARA, FOSL1, IL12A, RB1, FOXH1, EBI3, APP, GLI1, MYOG, HIF1A, NOTCH1, SMAD1, EP300, ADRB2, CTNNB1, GTF2H1, PRKCA, DDIT3, TLX1, CITED2, SRF, MYF6, NRIP1, E2F1, TP73, FGF2, ERCC2, SMAD2, GJA1, NCOA1, TP53, JUN, NCK1, HAND1, HAND2, FOXO1, STAT5A, ZNF423, SMAD3, TGFB1I1, IL4, SOX10, NCOA2, TCF4, 674 445 15360 3.2775647651118596 5.833111771380572E-13 1.6653345369377348E-14 2.1094237467877974E-13 GOTERM_BP_ALL GO:0009892~negative regulation of metabolic process 49 6.94% 3.8190987147296475E-9 SPTA1, PER1, HMGB1, SMARCA4, FZD1, PPARG, RYBP, PRKCG, PAWR, SMAD4, CBX2, RNF2, ELA2, ZBTB16, RB1, ID2, IGFBP3, MDFI, SERPINA5, CTNNB1, PRKCA, MDM4, RBL1, TWIST1, MYF6, NRIP1, STAT3, ORC2L, E2F1, NCOR1, IRF8, CDC45L, IRF2, TP53, ZMYND11, JUN, CDC6, ZEB2, MBD2, SIX3, HAND1, DAXX, ZNF423, MDM2, CAV1, FABP4, SMAD3, NCOA2, TCF4, 674 436 15360 2.561184765741976 2.006534331722154E-5 2.4175352053568133E-7 7.305877869345778E-6 GOTERM_BP_ALL GO:0007420~brain development 23 3.26% 1.8883488767117114E-6 NOTCH4, PRKG1, CTNNB1, FGFR1, WNT2, POU1F1, IGF1R, SIX3, GATA2, NEUROD1, E2F1, LRP2, GLI1, ATP2B2, SMARCA4, TP73, POU3F2, FYN, FGF2, ASCL1, SMAD1, PRKDC, ALK, 674 160 15360 3.2759643916913945 0.009872339696966215 7.81181640957529E-5 0.003612321039425659 GOTERM_BP_ALL GO:0009888~tissue development 30 4.25% 4.6446098619267893E-4 BMP1, CTNNB1, DLX5, FGF7, BMPR1A, EDA2R, PLG, MMP14, EGFR, NR5A1, S100A7, ERCC2, LAMA3, SMAD2, TIE1, ACHE, HCK, ALPL, PPARA, CTGF, HAND1, CSPG4, FOXH1, GLI1, POU3F2, SMAD3, NOTCH1, PTGS2, KRT17, ADRB2, 674 339 15360 2.016753761718442 0.9129127599850032 0.011835957904767325 0.8847758688742102 GOTERM_BP_ALL GO:0009887~organ morphogenesis 37 5.24% 7.567932651722578E-5 CTNNB1, FGFR1, MAPK1, LHX3, DCN, TLX1, DLX5, SRF, IGF1R, CASP8, PLG, ERBB2, MMP14, MYF5, PAX5, FGF2, MAP3K7IP1, MAP3K7, CRKL, S100A7, NOTCH4, TIE1, POU1F1, FGD1, ACTC1, CTGF, KLF1, FGF1, HAND1, HAND2, CSPG4, PAX3, GLI1, SIX1, ATP2B2, KDR, EP300, 674 415 15360 2.031818669336098 0.3280922522767006 0.0023640715759313258 0.14467413275198737 GOTERM_BP_ALL GO:0051094~positive regulation of developmental process 10 1.42% 0.004073070057389358 RB1, CTNNB1, ID2, LIMK1, PPARG, FGF2, DLX5, IGFBP3, ETS1, ADRB2, 674 72 15360 3.1651829871414443 0.9999999995134154 0.07397941894587623 7.510617166185007 GOTERM_BP_ALL GO:0007417~central nervous system development 35 4.96% 1.1291993268565481E-8 CTNNB1, FGFR1, TLX1, IGF1R, NEUROD1, E2F1, SMARCA4, TP73, FYN, WNT1, FGF2, ALK, PRKDC, NOTCH4, PRKG1, WNT2, POU1F1, SH3GL2, ZBTB16, DCX, ZEB2, PTPRZ1, SIX3, GATA2, LRP2, PARK2, GLI1, ATP2B2, ACCN1, POU3F2, NHLH1, ASCL1, SMAD1, SNTG2, GCM1, 674 260 15360 3.067792741383246 5.932637288319498E-5 6.311501493660998E-7 2.1601410249427744E-5 GOTERM_BP_ALL GO:0051093~negative regulation of developmental process 11 1.56% 0.005931970086194531 NOTCH4, CTNNB1, STAT5A, MAPK1, ZBTB16, NOTCH1, NFKBIA, IL4, LMO2, TWIST1, IAPP, 674 90 15360 2.785361028684471 0.9999999999999735 0.0968097642418142 10.757749813508832 GOTERM_BP_ALL GO:0001775~cell activation 27 3.82% 1.7116456105073574E-5 CD28, BCL10, LCP2, CADM1, VAV1, IL27RA, TNFRSF14, ERBB2, RHOH, MIF, RAG1, MAP3K7, NTRK1, RAG2, TRAF6, CASP3, RELB, PIK3R1, NCK1, IL12A, CD74, LCK, EBI3, SLAMF1, STAT5A, SMAD3, IL4, 674 238 15360 2.585342742438222 0.08600541314609811 5.800293309755622E-4 0.03273844198906639 GOTERM_BP_ALL GO:0051090~regulation of transcription factor activity 8 1.13% 0.005821384579033544 BCL10, ID2, DDIT3, CAMK2A, PYCARD, NPM1, EP300, EDA2R, 674 50 15360 3.6462908011869435 0.9999999999999524 0.09568138482097865 10.56764103411062 GOTERM_BP_ALL GO:0016540~protein autoprocessing 9 1.27% 0.0025644948953470435 TAF1, WNT2, DYRK1A, EGFR, JUN, FER, TTN, MAP3K3, IGF1R, 674 55 15360 3.729161046668465 0.9999986168714954 0.04945393699656908 4.793447016685337 GOTERM_BP_ALL GO:0016485~protein processing 12 1.70% 0.0043202406178188685 TAF1, WNT2, DYRK1A, MMP14, SCG5, PCSK2, EGFR, JUN, FER, TTN, MAP3K3, IGF1R, 674 100 15360 2.7347181008902077 0.9999999998679338 0.07723494985396151 7.948740033994294 GOTERM_BP_ALL GO:0030225~macrophage differentiation 5 0.71% 0.0025715933265368137 CASP8, RB1, ID2, CEBPE, MMP9, 674 14 15360 8.139041966935142 0.9999986676333646 0.049226750151213916 4.80640770057178 GOTERM_BP_ALL GO:0016481~negative regulation of transcription 38 5.38% 1.2587170824704206E-8 CTNNB1, MDM4, PER1, RBL1, MYF6, TWIST1, NRIP1, STAT3, ORC2L, E2F1, SMARCA4, HMGB1, FZD1, NCOR1, PPARG, RYBP, PAWR, SMAD4, RNF2, CBX2, IRF8, IRF2, ZMYND11, ZBTB16, MBD2, ZEB2, SIX3, HAND1, RB1, DAXX, MDM2, ID2, ZNF423, FABP4, SMAD3, MDFI, TCF4, NCOA2, 674 300 15360 2.886646884272997 6.613080938244753E-5 6.888851389330597E-7 2.407906496415535E-5 GOTERM_BP_ALL GO:0016477~cell migration 28 3.97% 6.082727086004526E-5 PRKCA, TWIST1, PARD6B, ITGB2, GAB1, CAP1, PLG, MMP14, FYN, WNT1, EGFR, IL16, LAMA3, TIE1, PRKG1, LAMA1, WNT2, DOCK2, ELA2, NCK1, ZEB2, CTGF, IL12A, ITGB3, CDK5, SIX1, ASCL1, KDR, 674 271 15360 2.354615831024779 0.2735576856659927 0.0019119196568958552 0.11629751135274757 GOTERM_BP_ALL GO:0001756~somitogenesis 8 1.13% 5.4107539445627594E-5 MEOX2, MYF5, SFRP1, ZEB2, EP300, MEOX1, MYF6, PRKDC, 674 24 15360 7.596439169139466 0.24745065021369161 0.0017111169178862795 0.10345615311371237 GOTERM_BP_ALL GO:0007399~nervous system development 83 11.76% 9.40231922231855E-14 FGFR1, BCL10, MAFK, NAIP, DYRK1A, BAI1, NEUROD1, MMP14, SMARCA4, FYN, WNT1, HOXC8, RND1, HEYL, MAP3K7, PMP22, DLG4, ALK, NRXN2, NOTCH4, WNT2, ACHE, POU1F1, EPHB1, ZBTB16, DCX, APP, LRP2, PARK2, GLI1, FOS, NHLH1, BRSK2, SMAD1, MYT1, SNTG2, EP300, GCM1, CTNNB1, LIMK1, TLX1, DLX5, NLGN1, IGF1R, PLP1, PARD6B, TWIST1, CASP8, STAT3, E2F1, MPZ, ERBB2, CHRM3, ERC2, TP73, PAX5, APBA2, FGF2, PTPN11, NTRK1, PRKDC, PRKG1, GJA1, SH3GL2, ZEB2, APBA1, PTPRZ1, SIX3, GATA2, CDK5, PICK1, PAX3, ZNF423, SIX1, ATP2B2, POU3F2, ACCN1, BDNF, ASCL1, PAX2, EPHB2, PARD3, NTRK2, 674 780 15360 2.425017119379137 4.940645670359345E-10 1.0082934487343209E-11 1.7988943668001411E-10 GOTERM_BP_ALL GO:0030218~erythrocyte differentiation 9 1.27% 1.9815475641674868E-4 RB1, EPB42, STAT5A, ID2, HCLS1, TAL1, ETS1, KLF1, LMO2, 674 38 15360 5.397469935967515 0.6469721231091209 0.005552486224930986 0.3783869231783754 GOTERM_BP_ALL GO:0032502~developmental process 301 42.63% 4.231202531712547E-44 KIT, CAPN3, MAFK, KCNJ8, FGF8, GATA4, GZMB, BAI1, NFKBIA, HAP1, PTPN6, STAT1, CAP1, MMP14, HMGB1, COL1A2, FYN, PRM1, RAG1, PRKCG, S100A7, PLCE1, POU1F1, ZBTB17, DFFA, TIMP3, ADRBK1, FOXH1, SRY, ID2, AHR, SRPK1, NTS, CASP5, GCM1, CLTCL1, NEDD9, DDIT3, PHOX2A, SERPINB2, NLGN1, ITGB2, NRIP1, PRKCE, MAP3K5, MPZ, PTPN11, PRKDC, HOXB9, LAMA1, CP, GJA1, AGTR2, RELB, E2F2, JUN, CTSB, PTPRZ1, FGF1, HOXB7, PICK1, PAX3, CAV1, ATP2B2, ACCN1, TNFRSF1B, WRN, GADD45G, IL4, MMP9, SPTA1, BCL10, MAPK1, DCN, IL27RA, EDA2R, IGFBP5, SMARCA4, DDX5, HOXC8, NR5A1, PMP22, CRKL, NRXN2, RNF2, EPHB1, ZBTB16, AKAP2, CD74, RB1, APP, GLI1, PTGS2, RAF1, EP300, SNTG2, MDFI, LMO2, ACTN2, EPB42, BMP1, SIAH2, CDC2, CADM1, TLX1, DLX5, MDM4, SRF, IGF1R, BMPR1A, ACTN3, MYF6, TWIST1, CASP8, STAT3, SALL1, CHRM3, PCGF2, TH, ERC2, PAX5, HOXB2, APBA2, MIF, SFRP1, PKP2, DFFB, NTRK1, GRN, SMAD2, PRKG1, SETDB1, IRF8, HCK, CARD9, ACTC1, TRAF1, HOXD10, ZEB2, GATA2, HAND2, CDK5, FOXO1, DAXX, SIX1, POU3F2, RAC1, BDNF, TGFB1I1, PLN, PAX2, SOX10, F11R, XAB2, DYRK1A, IKBKG, CAV3, MEOX1, MEOX2, BIN1, PLG, TNFRSF14, WNT1, RYBP, MAP3K7, LAMA3, DLG4, ALK, AXIN1, WNT2, PPARA, TTN, KLF1, ARHGDIB, IL12A, CEBPE, ELMO1, ITGB3, LRP1, DAG1, PARK2, FOS, HOXD4, TRAF3, BRSK2, NOTCH1, SMAD1, GZMA, KRT17, IGFBP3, EYA1, ADRB2, FGF7, NOV, PLP1, IFI16, CSRP3, ERBB2, ATG12, TP73, FGF2, DNM2, MAP3K7IP1, AR, CASP2, GNA12, ERCC2, ATG5, CTGF, REN, ACTB, GJA8, HDAC1, DYNLL1, STAT5A, SGCG, DACH1, RAC3, SMAD3, CRYAA, MAPK8, EPHB2, S100A4, CD28, FGFR1, NAIP, ATXN2, TAL1, LHX3, ETS1, CALR, IAPP, NEUROD1, MYF5, FZD1, PPARG, RHOH, EGFR, NPM1, RND1, PAWR, HEYL, SMAD4, NOTCH4, PPP3R1, SEPT4, ACHE, PPARGC1A, CASP3, HCLS1, PIK3R1, CASP1, DCX, ABL1, CSPG4, HOXA9, LRP2, EAF2, TRAIP, MYOG, TBP, NHLH1, MYT1, CD44, FES, CTNNB1, ANXA13, HOXA5, PRKCA, BCL2L1, LIMK1, CITED2, PYCARD, PARD6B, PAK1, E2F1, NFE2, RAG2, TIE1, TRAF6, FGD1, MEIS1, TP53, SH3GL2, ALPL, NCK1, DIXDC1, APBA1, SIX3, HAND1, CSF1R, LCK, YWHAZ, PLCG1, ZNF423, HIC1, ASCL1, KDR, PARD3, VCP, NTRK2, 674 3262 15360 2.102876937379809 2.2230738101617723E-40 2.2230738101617723E-40 8.094226524015073E-41 GOTERM_BP_ALL GO:0032501~multicellular organismal process 299 42.35% 7.320418079342114E-31 KIT, CAPN3, MAFK, RPGRIP1, KCNJ8, FGF8, GATA4, BAI1, NFKBIA, HAP1, CRY1, MMP14, PPEF1, COL1A2, FYN, PRM1, RAG1, PLAT, S100A7, PLCE1, POU1F1, ZBTB17, ADRA2A, ARRB2, TIMP3, CACNA1B, ADRBK1, FOXH1, EBI3, SRY, SLC34A1, ID2, NTS, GCM1, DDIT3, PHOX2A, NLGN1, RPGR, GRM1, ITGB2, NRIP1, MPZ, PTPN11, PPEF2, PRKDC, HOXB9, LAMA1, GJA1, AGTR2, DLG2, RELB, ARRB1, MBD2, PTPRZ1, FGF1, HOXB7, CUBN, PICK1, PAX3, CAV1, ATP2B2, ACCN1, WRN, GADD45G, IL4, MMP3, MMP9, RBP4, BCL10, MAPK1, DCN, HNF4A, IL27RA, REL, EDA2R, SMARCA4, HOXC8, NR5A1, PMP22, CRKL, GJA3, SNCB, NRXN2, RNF2, ELA2, EPHB1, ZBTB16, CD74, RB1, APP, GLI1, PTGS2, EP300, SNTG2, MDFI, LMO2, ACTN2, EPB42, BMP1, SIAH2, DLGAP2, LCP2, SLC6A1, C1QA, CADM1, TLX1, DLX5, MMP7, SRF, IGF1R, BMPR1A, ACTN3, TWIST1, MYF6, STAT3, SCN5A, CASP8, SALL1, CHRM3, TH, PCGF2, ERC2, PAX5, HOXB2, APBA2, MIF, SFRP1, PKP2, NTRK1, GRN, SMAD2, PRKG1, OPRL1, SETDB1, IRF8, HCK, ACTC1, HOXD10, ZEB2, GATA2, HAND2, CDK5, FOXO1, SIX1, POU3F2, BDNF, PLN, APOH, PAX2, SOX10, XAB2, TRPV1, AKAP5, DYRK1A, TRPC3, IKBKG, CAV3, NOS1, SLC8A1, MEOX1, MEOX2, BIN1, PLG, PDC, WNT1, KCNK3, RYBP, MAP3K7, LAMA3, ATP7B, DLG4, ALK, AXIN1, WNT2, PPARA, TTN, KLF1, ARHGDIB, IL12A, CEBPE, ITGB3, LRP1, S100A1, DAG1, PARK2, FOS, HOXD4, SP4, BRSK2, NOTCH1, CAMK4, SMAD1, KRT17, IGFBP3, EYA1, HOMER1, ADRB2, FGF7, PLP1, IFI16, CSRP3, ERBB2, TP73, FGF2, MAP3K7IP1, PNOC, AR, GNA12, ERCC2, TNNT2, CTGF, REN, ACTB, GJA8, SNAP25, GABARAPL2, STAT5A, SGCG, DACH1, RAC3, FABP4, SMAD3, CRYAA, EPHB2, CD28, FGFR1, NAIP, OPRD1, LIN7A, TAL1, LHX3, ETS1, IAPP, NEUROD1, MYF5, KIFC3, FZD1, RHOH, EGFR, MYL3, RND1, HEYL, KCNJ12, SMAD4, NOTCH4, PPP3R1, ACHE, PPARGC1A, CASP3, HCLS1, PIK3R1, DCX, SLC22A2, CSPG4, HOXA9, LRP2, MYOG, NHLH1, MYT1, CD44, FES, CTNNB1, HOXA5, PRKCA, LIMK1, CITED2, PYCARD, SERPIND1, PARD6B, E2F1, MYH4, NFE2, RAG2, TIE1, TRAF6, STX1A, FGD1, PDE4D, MEIS1, TP53, SH3GL2, ALPL, NCK1, KIF5A, DIXDC1, APBA1, SIX3, HAND1, CSF1R, LCK, PLAU, PLCG1, ZNF423, HIC1, ASCL1, KDR, CR2, PARD3, NTRK2, 674 3759 15360 1.8127177267140466 3.8461476588863465E-27 5.494496655551923E-28 1.4003849199038024E-27 GOTERM_BP_ALL GO:0007389~pattern specification process 28 3.97% 9.64022030419432E-10 CTNNB1, HOXA5, CITED2, BMPR1A, MEOX1, MYF6, NEUROD1, MEOX2, PCGF2, MYF5, FGF2, SFRP1, CRKL, SMAD4, PRKDC, RNF2, SMAD2, NOTCH4, AXIN1, ZEB2, FGF1, FOXH1, GLI1, SIX1, ASCL1, SMAD1, EP300, MDFI, 674 157 15360 4.064336880303918 5.064959206824149E-6 6.493553683650788E-8 1.8441596694174223E-6 GOTERM_BP_ALL GO:0051049~regulation of transport 17 2.41% 7.588473811113639E-5 GJA1, PRKCA, CAV3, SLC9A3, NFKBIA, GATA2, SNX17, BIN1, TRPV6, SMAD3, PTPN11, RAC1, PLN, CRYAA, MDFI, CBL, ADRB2, 674 121 15360 3.2018049390587833 0.3288170607035754 0.002342625538499399 0.14506654249881734 GOTERM_BP_ALL GO:0045321~leukocyte activation 27 3.82% 1.7298181908499777E-6 CD28, BCL10, LCP2, CADM1, VAV1, IL27RA, TNFRSF14, ERBB2, RHOH, MIF, RAG1, MAP3K7, NTRK1, RAG2, TRAF6, CASP3, RELB, PIK3R1, NCK1, IL12A, CD74, LCK, EBI3, SLAMF1, STAT5A, SMAD3, IL4, 674 210 15360 2.9300551080966515 0.009047297302454016 7.270513793466993E-5 0.00330906417864707 GOTERM_BP_ALL GO:0006366~transcription from RNA polymerase II promoter 103 14.59% 1.5696119044403033E-29 GATA4, POU2AF1, FHL2, STAT1, YBX1, PARP1, HMGB1, NRF1, RYBP, IKBKAP, POU1F1, RFXANK, PPARA, KLF1, FOXH1, FOS, ID2, AHR, SP4, NOTCH1, SMAD1, SUB1, HCFC1, ADRB2, GTF2H1, MAX, DDIT3, PHOX2A, NMI, NRIP1, ORC2L, ERCC2, CCNT1, RFXAP, E2F2, JUN, MBD2, CRK, GTF2F2, STAT5A, PAX3, SMAD3, IL4, SREBF2, TCF4, HNF4A, REL, NEUROD1, ANKRD1, SMARCA4, MYF5, PPARG, TRIP4, NR5A1, PAWR, SMAD4, CBX2, RNF2, DBP, PPARGC1A, FOSL1, ABL1, CHD1, RB1, APP, GLI1, MYOG, TBP, HIF1A, EP300, MDFI, CTNNB1, TLX1, CITED2, MDM4, SRF, RBL1, TWIST1, MYF6, STAT3, E2F1, NCOR1, PAX5, NFE2, MYC, POLR2A, SMAD2, IRF8, IRF2, TP53, ZMYND11, HAND1, GATA2, HAND2, FOXO1, MDM2, POU3F2, TGFB1I1, COPS5, ASCL1, SOX10, PAX2, NCOA2, 674 669 15360 3.508669212651861 8.246740945929353E-26 8.246740945929353E-27 3.0026438616703E-26 GOTERM_BP_ALL GO:0006357~regulation of transcription from RNA polymerase II promoter 75 10.62% 4.940321798495733E-22 HNF4A, FHL2, ANKRD1, NEUROD1, MYF5, HMGB1, SMARCA4, NRF1, PPARG, RYBP, PAWR, NR5A1, SMAD4, IKBKAP, CBX2, RNF2, DBP, PPARGC1A, POU1F1, PPARA, FOSL1, CHD1, ABL1, RB1, FOXH1, APP, FOS, GLI1, ID2, MYOG, SP4, HIF1A, NOTCH1, SMAD1, EP300, SUB1, MDFI, ADRB2, CTNNB1, GTF2H1, TLX1, CITED2, MDM4, SRF, RBL1, MYF6, TWIST1, NRIP1, STAT3, ORC2L, E2F1, NFE2, ERCC2, MYC, SMAD2, IRF8, IRF2, TP53, ZMYND11, JUN, MBD2, HAND1, CRK, HAND2, FOXO1, STAT5A, MDM2, POU3F2, SMAD3, ASCL1, SOX10, IL4, SREBF2, NCOA2, TCF4, 674 476 15360 3.590753808941974 2.595645072929658E-18 1.3661289857524517E-19 9.450760968978986E-19 GOTERM_BP_ALL GO:0030182~neuron differentiation 23 3.26% 0.0015093750408246788 PRKG1, GJA1, LIMK1, TLX1, DLX5, NLGN1, BAI1, PTPRZ1, PARD6B, GATA2, CDK5, APP, PICK1, SIX1, ATP2B2, POU3F2, PTPN11, HOXC8, BRSK2, ASCL1, RND1, PAX2, PARD3, 674 250 15360 2.0966172106824925 0.9996424542954753 0.03136990546089502 2.8482434381135957 GOTERM_BP_ALL GO:0006355~regulation of transcription, DNA-dependent 168 23.80% 5.100109580758839E-10 MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, HMGB1, NRF1, RYBP, CIITA, IKBKAP, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, NOTCH1, SMAD1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, ASCC2, SAFB, IFI16, NRIP1, ORC2L, TP73, AR, CARM1, ERCC2, HOXB9, CCNT1, RELB, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PAX3, DACH1, SMAD3, IL4, SREBF2, TCF4, RUNX1T1, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, NEUROD1, MYF5, SMARCA4, PPARG, TRIP4, HOXC8, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, PPARGC1A, TCEA2, HCLS1, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, ASCL1, PAX2, SOX10, WT1, NCOA2, 674 2432 15360 1.574262064657192 2.6795937967394323E-6 3.572796447581794E-8 9.75643188461106E-7 GOTERM_BP_ALL GO:0006351~transcription, DNA-dependent 173 24.50% 1.4026617308200498E-10 MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, HMGB1, NRF1, RYBP, CIITA, IKBKAP, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, NOTCH1, SMAD1, HCFC1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, NMI, ASCC2, SAFB, IFI16, NRIP1, ORC2L, TP73, AR, CARM1, ERCC2, HOXB9, CCNT1, RELB, RFXAP, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PAX3, DACH1, SMAD3, IL4, SREBF2, TCF4, RUNX1T1, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, NEUROD1, MYF5, SMARCA4, PPARG, TRIP4, HOXC8, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, TCEA2, PPARGC1A, HCLS1, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, COPS5, ASCL1, PAX2, SOX10, WT1, NCOA2, 674 2487 15360 1.585264145067705 7.369579863025777E-7 1.0837621355896943E-8 2.683269939574018E-7 GOTERM_BP_ALL GO:0006350~transcription 184 26.06% 1.3165592449343918E-10 PPP5C, MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, HMGB1, NRF1, RYBP, CIITA, IKBKAP, CDK2, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, NOTCH1, SMAD1, HCFC1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, NMI, ASCC2, SAFB, IFI16, NRIP1, ORC2L, TP73, DNM2, AR, CARM1, ERCC2, HOXB9, CCNT1, RELB, RFXAP, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PAX3, DACH1, FABP4, SMAD3, IL4, SREBF2, TCF4, RUNX1T1, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, EDA2R, NEUROD1, MYF5, SMARCA4, FZD1, PPARG, RHOH, TRIP4, HOXC8, NPM1, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, TCEA2, PPARGC1A, HCLS1, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, PYCARD, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, COPS5, ASCL1, PAX2, SOX10, XAB2, WT1, NCOA2, 674 2695 15360 1.5559311396530557 6.917199035783028E-7 1.0641848291470524E-8 2.518557584707537E-7 GOTERM_BP_ALL GO:0016311~dephosphorylation 18 2.55% 3.3539635281083405E-4 ACP1, KIT, CDC25A, PPP5C, PTPRS, PTPRH, PTPRG, PTPN6, PTPRZ1, CDC14A, PPEF1, PPP1CA, PTPN11, PPEF2, CDKN3, DUSP6, PTPRT, PTPRN, 674 151 15360 2.7166073849902728 0.828379222261387 0.008861853859724489 0.6396611783578532 GOTERM_BP_ALL GO:0016310~phosphorylation 92 13.03% 3.777021245618804E-15 KIT, FGFR1, BCL10, DYRK1A, GSK3A, MAPK1, SRC, MARK1, STAT1, TNFRSF14, MAP2K7, CDK3, FYN, NEK2, EGFR, PRKCG, CRKL, MAP3K7, ALK, IKBKAP, TAF1, CDK2, NUAK1, WNT2, MAP3K4, PRKD3, HCLS1, ROS1, EPHB1, PTK2, PIK3R1, ABL1, TTN, IL12A, ADRBK1, MOS, MAP3K14, SRPK1, SNF1LK2, BRSK2, RAF1, CAMK2A, CAMK4, IGFBP3, PRKACA, FES, PRKCA, LIMK1, PFTK1, CASK, CDC2, TEC, LIPE, CBLC, ABI1, PRKAR2A, IGF1R, MAP3K3, BMPR1A, ITGB2, PAK1, FGR, PRKCE, MAP3K5, CSNK1A1, CTBP1, ERBB2, CSNK2A1, FRK, FGF2, AXL, MAPK14, FER, BLK, NTRK1, EPHA3, PRKG1, TIE1, CCNT1, HCK, JUN, CSF1R, CDK5, LCK, PICK1, MAP3K8, KDR, IL4, MAPK8, EPHB2, NTRK2, FGFR4, 674 867 15360 2.418243610937131 1.9832580022693946E-11 4.6118664442929E-13 7.2164496600635175E-12 GOTERM_BP_ALL GO:0030154~cell differentiation 196 27.76% 1.790166091084586E-34 GZMB, BAI1, NFKBIA, PTPN6, STAT1, MMP14, HMGB1, FYN, PRM1, RAG1, PRKCG, S100A7, DFFA, TIMP3, SRY, AHR, ID2, SRPK1, CASP5, GCM1, DDIT3, SERPINB2, NLGN1, ITGB2, PRKCE, MAP3K5, PTPN11, PRKDC, GJA1, AGTR2, RELB, E2F2, CTSB, JUN, FGF1, PTPRZ1, PICK1, PAX3, ATP2B2, TNFRSF1B, WRN, GADD45G, IL4, MMP9, BCL10, MAPK1, EDA2R, SMARCA4, HOXC8, NR5A1, ZBTB16, CD74, RB1, APP, GLI1, PTGS2, RAF1, EP300, MDFI, LMO2, ACTN2, EPB42, BMP1, SIAH2, CDC2, CADM1, TLX1, DLX5, MDM4, IGF1R, BMPR1A, ACTN3, TWIST1, MYF6, CASP8, SALL1, PAX5, MIF, SFRP1, DFFB, NTRK1, SMAD2, PRKG1, IRF8, CARD9, ACTC1, TRAF1, ZEB2, GATA2, CDK5, HAND2, DAXX, FOXO1, SIX1, POU3F2, TGFB1I1, SOX10, PAX2, F11R, IKBKG, BIN1, PLG, TNFRSF14, WNT1, RYBP, MAP3K7, LAMA3, AXIN1, WNT2, KLF1, TTN, CEBPE, IL12A, ELMO1, TRAF3, NOTCH1, BRSK2, IGFBP3, GZMA, ADRB2, PLP1, IFI16, CSRP3, ERBB2, ATG12, TP73, FGF2, DNM2, CASP2, GNA12, ERCC2, ATG5, REN, CTGF, HDAC1, ACTB, STAT5A, SMAD3, MAPK8, CRYAA, S100A4, CD28, FGFR1, NAIP, ATXN2, TAL1, CALR, ETS1, NEUROD1, IAPP, MYF5, FZD1, RHOH, PPARG, RND1, NPM1, PAWR, NOTCH4, SEPT4, PPP3R1, ACHE, CASP3, PPARGC1A, HCLS1, PIK3R1, DCX, CASP1, ABL1, CSPG4, TRAIP, EAF2, MYOG, TBP, NHLH1, MYT1, CTNNB1, LIMK1, BCL2L1, PRKCA, ANXA13, PYCARD, PARD6B, PAK1, E2F1, RAG2, TRAF6, TP53, HAND1, LCK, YWHAZ, ZNF423, ASCL1, KDR, PARD3, VCP, NTRK2, 674 1835 15360 2.434172333217442 9.405532642558415E-31 2.3513831606396038E-31 3.424560688893452E-31 GOTERM_BP_ALL GO:0016265~death 100 14.16% 2.561640492900599E-20 IKBKG, GZMB, NFKBIA, PTPN6, STAT1, PLG, TNFRSF14, HMGB1, RYBP, PRKCG, MAP3K7, AXIN1, DFFA, IL12A, ELMO1, TIMP3, AHR, TRAF3, IGFBP3, GZMA, CASP5, ADRB2, DDIT3, SERPINB2, IFI16, ITGB2, PRKCE, MAP3K5, ATG12, TP73, FGF2, DNM2, CASP2, ERCC2, PRKDC, GJA1, AGTR2, E2F2, CTSB, ATG5, HDAC1, STAT5A, PAX3, SMAD3, TNFRSF1B, WRN, GADD45G, IL4, MAPK8, CRYAA, MMP9, CD28, BCL10, NAIP, ATXN2, MAPK1, CALR, IAPP, NPM1, PAWR, SEPT4, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, CD74, APP, TRAIP, EAF2, TBP, RAF1, EP300, ACTN2, SIAH2, BCL2L1, PRKCA, CDC2, CADM1, MDM4, PYCARD, IGF1R, ACTN3, PAK1, CASP8, E2F1, MIF, SFRP1, DFFB, TRAF6, CARD9, TP53, ACTC1, TRAF1, CDK5, LCK, DAXX, FOXO1, YWHAZ, VCP, 674 834 15360 2.7325320752300235 1.3458859149699747E-16 5.851677891173803E-18 4.9003795652000954E-17 GOTERM_BP_ALL GO:0042330~taxis 21 2.97% 7.966086769224263E-6 CXCL2, CCL8, PRKCA, MAPK1, DOCK2, ELA2, CCR1, CCR3, FOSL1, SERPIND1, ITGB2, RALA, PLAU, FGF2, IL4, MAPK14, FER, PLD1, CREB3, DEFB1, IL16, 674 149 15360 3.2119172325891703 0.04099020136101139 2.8663005479567794E-4 0.015237903260423291 GOTERM_BP_ALL GO:0042325~regulation of phosphorylation 11 1.56% 0.0013900965105938846 PRKCE, BCL10, PRKCA, HCLS1, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 674 74 15360 3.387601251102735 0.9993302781677341 0.029390657691592326 2.625988795012746 GOTERM_BP_ALL GO:0009792~embryonic development ending in birth or egg hatching 20 2.83% 5.626461294673465E-7 BCL10, SETDB1, ZEB2, MEOX1, MYF6, HAND2, MEOX2, CASP8, PLCG1, MYF5, SIX1, SMARCA4, SFRP1, MAP3K7IP1, XAB2, EP300, MAP3K7, GNA12, PRKDC, GRN, 674 115 15360 3.9633595665075476 0.002951778505698055 2.639379092639338E-5 0.0010763280563375055 GOTERM_BP_ALL GO:0009790~embryonic development 42 5.95% 7.774474420533529E-11 CTNNB1, FGFR1, BCL10, DDIT3, FGF8, DLX5, MEOX1, MYF6, EDA2R, MEOX2, CASP8, MYF5, SMARCA4, SFRP1, MAP3K7IP1, MAP3K7, GNA12, SMAD4, LAMA3, GRN, PRKDC, NOTCH4, SMAD2, RNF2, LAMA1, SETDB1, ZBTB16, ZEB2, HAND1, HAND2, CDK5, FOXH1, PICK1, GLI1, PLCG1, SIX1, ATP2B2, SMAD3, SMAD1, XAB2, EP300, MDFI, 674 299 15360 3.201175034486865 4.084705681473011E-7 6.382353867628865E-9 1.4872443276914282E-7 GOTERM_BP_ALL GO:0030099~myeloid cell differentiation 19 2.69% 5.55530312829773E-8 EPB42, CTNNB1, IRF8, RELB, HCLS1, TAL1, NFKBIA, ZBTB16, ETS1, KLF1, CEBPE, IFI16, RB1, CASP8, STAT5A, ID2, IL4, MMP9, LMO2, 674 90 15360 4.8110781404549945 2.918330429361182E-4 2.918752085245835E-6 1.0627205611069002E-4 GOTERM_BP_ALL GO:0030098~lymphocyte differentiation 11 1.56% 0.0025199522722968008 LCK, RAG2, STAT5A, ERBB2, RELB, RHOH, PIK3R1, IL4, RAG1, NTRK1, CD74, 674 80 15360 3.13353115727003 0.999998251127364 0.048794047910704186 4.712080604853086 GOTERM_BP_ALL GO:0030097~hemopoiesis 30 4.25% 5.225631364896386E-9 KIT, EPB42, CTNNB1, TAL1, NFKBIA, ETS1, IFI16, CASP8, ERBB2, RHOH, RAG1, NTRK1, NOTCH4, RAG2, IRF8, RELB, HCLS1, PIK3R1, ZBTB16, KLF1, CEBPE, CD74, RB1, LCK, STAT5A, ID2, KDR, IL4, MMP9, LMO2, 674 192 15360 3.5608308605341246 2.7455090402694893E-5 3.1199389793901133E-7 9.996553396174335E-6 GOTERM_BP_ALL GO:0016192~vesicle-mediated transport 37 5.24% 0.0032694763760403762 CTNNB1, AKAP3, LIN7A, VAV1, NLGN1, SYP, SNX17, CAP1, BIN1, TRPV6, STXBP1, DNM2, STX12, EXOC3, EXOC2, CCL8, STX1A, CPNE1, SLC9A3, ELA2, SH3GL2, CEBPE, GATA2, ELMO1, ROPN1B, SNAP25, CUBN, APP, LRP1, LRP2, PICK1, ARF1, RAC1, MAPK8IP1, CBL, ADRB2, CLTCL1, 674 509 15360 1.6565908600677424 0.999999966306857 0.061517124419236624 6.072507391936388 GOTERM_BP_ALL GO:0001568~blood vessel development 19 2.69% 0.0015588892005192986 NOTCH4, TIE1, CTNNB1, FGFR1, CTGF, FGF1, HAND1, CSPG4, HAND2, CASP8, FOXO1, PLG, ERBB2, MMP14, FGF2, KDR, MAP3K7, CRKL, S100A7, 674 188 15360 2.3031757055369657 0.9997244646066064 0.032255504882576 2.940363115075828 GOTERM_BP_ALL GO:0045165~cell fate commitment 16 2.27% 6.732082100260898E-6 SMAD2, NOTCH4, CTNNB1, TLX1, TAL1, FGF1, GATA2, NEUROD1, SALL1, SMARCA4, WNT1, FGF2, NOTCH1, ASCL1, KDR, GCM1, 674 89 15360 4.096955956389825 0.03475225344627986 2.508229954827357E-4 0.01287758547584561 GOTERM_BP_ALL GO:0030036~actin cytoskeleton organization and biogenesis 26 3.68% 6.0362254382251965E-6 SPTA1, LIMK1, CALR, CAP1, FHOD1, PDE4DIP, RND1, WIPF1, PRKG1, EPB41L3, DOCK2, FGD1, ACTC1, ADRA2A, NCK1, ABL1, ARHGDIB, TTN, ACTB, ELMO1, CRK, DYNLL1, RAC3, RAC1, SORBS1, NEDD9, 674 211 15360 2.8081623468856796 0.031216796353867537 2.348940685892309E-4 0.011546576258947283 GOTERM_BP_ALL GO:0046777~protein amino acid autophosphorylation 9 1.27% 0.002015469564210723 TAF1, WNT2, DYRK1A, EGFR, JUN, FER, TTN, MAP3K3, IGF1R, 674 53 15360 3.869884105033313 0.9999750830592198 0.040405990547328074 3.7859254983222734 GOTERM_BP_ALL GO:0030029~actin filament-based process 28 3.97% 2.197788905212823E-6 SPTA1, LIMK1, CALR, CAP1, FHOD1, PDE4DIP, MYH4, WIPF1, RND1, PRKG1, EPB41L3, FGD1, DOCK2, ACTC1, ADRA2A, TNNT2, NCK1, ABL1, ARHGDIB, TTN, ACTB, ELMO1, CRK, DYNLL1, RAC3, RAC1, SORBS1, NEDD9, 674 226 15360 2.8234552664058192 0.011480782607717455 9.02083965800271E-5 0.004204253213424547 GOTERM_BP_ALL GO:0001525~angiogenesis 17 2.41% 5.321523818300902E-4 NOTCH4, TIE1, CTNNB1, FGFR1, CTGF, FGF1, HAND1, CSPG4, HAND2, CASP8, PLG, MMP14, ERBB2, FGF2, KDR, MAP3K7, S100A7, 674 143 15360 2.7092195638189702 0.9389872736694709 0.013355554804534986 1.0131036079153777 GOTERM_BP_ALL GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 17 2.41% 0.0017799434879498457 CP, OPRL1, PRKCA, ELA2, CCR3, CCR1, CALR, IREB2, CSRP3, LCK, ATOX1, APP, ATP2B2, PLN, ATP7B, MYC, PLCE1, 674 160 15360 2.421364985163205 0.999913913317504 0.0366046943644287 3.3506194559995928 GOTERM_BP_ALL GO:0030001~metal ion transport 36 5.10% 5.651512444394557E-4 TRPC3, KCNJ8, CAV3, KCNJ16, SLC17A1, KCNA5, SLC8A1, SLC9A1, KCNJ10, SCN5A, ATOX1, ITPR1, KCNB1, KCNJ2, TRPV6, FYN, KCNK3, KCNJ12, ATP7B, CCL8, CP, GJA1, SCN3A, ACCN2, SLC9A3, SLC22A2, KCNJ9, KCNJ15, CACNA1B, SLC34A1, ATP2B2, ACCN1, PLN, ATP1B2, TRPV1, ADRB2, 674 443 15360 1.8519535671942715 0.9487040772054293 0.0140439928734295 1.0756049605086915 GOTERM_BP_ALL GO:0042221~response to chemical stimulus 53 7.51% 2.7414943577054587E-6 CXCL2, ASIP, BCL10, DNAJC3, ABCB4, MAPK1, NFKBIA, RALA, ATOX1, MMP14, PDZK1, PPARG, PRKCG, DEFB1, S100A7, ATP7B, CCL8, WNT2, HSP90AA1, DOCK2, ELA2, HCLS1, CCR1, FOSL1, TTN, AHR, TRH, PTGS2, CREB3, PRKCA, DDIT3, LIPE, CCR3, SERPIND1, ITGB2, GAB1, FGF2, FER, MAPK14, IL16, ERCC2, RAG2, CP, TNNT2, REN, ACTB, LCK, PLAU, IL4, TRPV1, VCP, PLD1, IRS1, 674 606 15360 1.9931251285365925 0.01430059219743407 1.1165137194513175E-4 0.005244306961893486 GOTERM_BP_ALL GO:0001501~skeletal development 20 2.83% 0.005546620577167933 BMP1, CTNNB1, FGFR1, ACHE, HOXA5, DLX5, ZBTB16, ALPL, HOXD10, CTGF, BMPR1A, TWIST1, MMP14, GLI1, MYF5, COL1A2, SIX1, EGFR, MMP9, ADRB2, 674 228 15360 1.999062939247228 0.9999999999997965 0.0937083867323758 10.09362827240553 GOTERM_BP_ALL GO:0009719~response to endogenous stimulus 31 4.39% 0.003324816557966649 ASIP, GTF2H1, DDIT3, MAPK1, CDC2, IFI16, CRY1, MMP14, UPF1, PARP1, ERCC4, HMGB1, TP73, PTPN11, PRKCG, ERCC2, PRKDC, WNT2, TP53, HCLS1, ABL1, REN, CHAF1A, FANCA, CHAF1B, RAD52, GADD45G, TRH, XAB2, VCP, IRS1, 674 403 15360 1.753024423647569 0.9999999748319536 0.062304251962399415 6.172219644565424 GOTERM_BP_ALL GO:0022610~biological adhesion 57 8.07% 1.4838207202866376E-4 DSC1, BCL10, DSG3, INPPL1, BAI1, IGFALS, MMP14, MYF5, EGFR, RND1, LAMA3, NRXN2, ACHE, PPFIA1, CCR1, ABL1, ARHGDIB, TTN, IL12A, ITGB3, DAG1, APP, PXN, CD44, SORBS1, NEDD9, MAGI1, HSPG2, ACTN2, BMP1, CTNNB1, CNTN1, CASK, VAV1, CADM1, NLGN1, CCR3, ACTN3, ITGB2, MPZ, CLSTN3, PKP2, FER, LAMA1, PTPRS, APBA1, ZEB2, CTGF, CDK5, ROPN1B, STAT5A, DSG2, SELE, TGFB1I1, RAC1, F11R, PPFIA2, 674 774 15360 1.6782830722517426 0.5414368437694383 0.004322062064572196 0.2834711831839254 GOTERM_BP_ALL GO:0022607~cellular component assembly 54 7.65% 1.0059247536599542E-6 BCL10, LIN7A, SRC, CREBBP, HMGB1, SMARCA4, NPM1, SMAD4, DLG4, MPP6, IKBKAP, TAF1, PPARGC1A, APC2, SLC9A3R1, PTK2, TAF13, TTN, CHAF1A, CD74, ITGB3, DAG1, PXN, CHAF1B, TBP, HCFC1, CLTCL1, MAGI1, ADRB2, ACTN2, MDM4, IGF1R, PARD6B, HIST3H3, TJP1, WIPF1, GJA1, TP53, E2F2, ACTC1, TRAF1, NCK1, MBD2, APBA1, ACTB, GTF2F2, PICK1, MDM2, CAV1, FANCA, SMAD3, KIFAP3, PARD3, SLC9A3R2, 674 602 15360 2.0442244940209195 0.005271189579276747 4.441188194526102E-5 0.0019243013104741635 GOTERM_BP_ALL GO:0006259~DNA metabolic process 58 8.22% 0.0011542305631374442 KPNA2, IL27RA, CREBBP, CRY1, UPF1, PARP1, HMGB1, SMARCA4, PRM1, RAG1, PRKCG, RNF2, CBX2, CDK2, ACHE, PPARGC1A, CHD1, ABL1, DFFA, RCC1, KLF1, CHAF1A, RB1, FOS, GLI1, CHAF1B, EP300, GTF2H1, RBL1, SAFB, HIST3H3, ORC2L, ERCC4, DNMT3A, PCGF2, TP73, NCOR1, PPFIBP2, DFFB, CBX1, ERCC2, CARM1, PRKDC, RAG2, SETDB1, CDC45L, TP53, CDC6, CTGF, HDAC1, PICK1, FANCA, RAD52, WRN, GADD45G, IL4, XAB2, VCP, 674 860 15360 1.5369539714305431 0.9976838058435554 0.02549005292506168 2.1850745839207653 GOTERM_BP_ALL GO:0007275~multicellular organismal development 218 30.88% 8.912625506907114E-30 KIT, CAPN3, MAFK, KCNJ8, FGF8, GATA4, BAI1, NFKBIA, HAP1, MMP14, COL1A2, FYN, PRM1, RAG1, S100A7, PLCE1, POU1F1, ZBTB17, ADRBK1, FOXH1, SRY, ID2, NTS, GCM1, DDIT3, NLGN1, ITGB2, NRIP1, MPZ, PTPN11, PRKDC, HOXB9, LAMA1, GJA1, AGTR2, RELB, FGF1, PTPRZ1, HOXB7, PICK1, PAX3, CAV1, ATP2B2, ACCN1, WRN, GADD45G, IL4, MMP9, BCL10, MAPK1, DCN, IL27RA, EDA2R, SMARCA4, HOXC8, NR5A1, PMP22, CRKL, NRXN2, RNF2, EPHB1, ZBTB16, CD74, RB1, APP, GLI1, PTGS2, EP300, SNTG2, MDFI, LMO2, EPB42, BMP1, SIAH2, CADM1, TLX1, DLX5, SRF, IGF1R, BMPR1A, TWIST1, MYF6, STAT3, CASP8, SALL1, CHRM3, PCGF2, ERC2, APBA2, HOXB2, PAX5, PKP2, SFRP1, NTRK1, GRN, SMAD2, PRKG1, IRF8, SETDB1, HCK, ACTC1, HOXD10, ZEB2, GATA2, CDK5, HAND2, FOXO1, SIX1, POU3F2, BDNF, PLN, PAX2, XAB2, DYRK1A, CAV3, MEOX1, MEOX2, BIN1, PLG, WNT1, RYBP, MAP3K7, LAMA3, ALK, DLG4, AXIN1, WNT2, PPARA, ARHGDIB, KLF1, TTN, CEBPE, ITGB3, LRP1, FOS, PARK2, HOXD4, NOTCH1, BRSK2, SMAD1, KRT17, IGFBP3, EYA1, ADRB2, FGF7, PLP1, IFI16, CSRP3, ERBB2, TP73, FGF2, MAP3K7IP1, AR, GNA12, ERCC2, CTGF, GJA8, ACTB, STAT5A, DACH1, SGCG, SMAD3, EPHB2, FGFR1, NAIP, LHX3, TAL1, ETS1, NEUROD1, MYF5, FZD1, RHOH, EGFR, RND1, HEYL, SMAD4, NOTCH4, PPP3R1, ACHE, CASP3, HCLS1, PIK3R1, DCX, CSPG4, HOXA9, LRP2, MYOG, NHLH1, MYT1, CD44, FES, CTNNB1, HOXA5, LIMK1, CITED2, PARD6B, E2F1, NFE2, RAG2, TIE1, FGD1, MEIS1, TP53, SH3GL2, ALPL, DIXDC1, APBA1, SIX3, HAND1, CSF1R, LCK, PLCG1, ZNF423, HIC1, ASCL1, KDR, PARD3, NTRK2, 674 2349 15360 2.114972846580337 4.6826934413289974E-26 5.202992712587775E-27 1.7049717955103983E-26 GOTERM_BP_ALL GO:0050896~response to stimulus 187 26.49% 5.850539912686488E-7 KIT, CXCL2, RPGRIP1, TRPC3, DNAJC3, KCNJ8, IKBKG, NFKBIA, POU2AF1, PTPN6, PER1, CRY1, STAT1, RALA, PLG, PARP1, MMP14, TNFRSF14, UPF1, MAP2K7, PDC, PPEF1, HMGB1, FYN, CTSS, PRKCG, RAG1, PLAT, MAP3K7, S100A7, DEFB1, ATP7B, DLG4, CIITA, IKBKAP, HTR1A, CCL8, WNT2, DOCK2, ADRA2A, PPARA, RFXANK, TTN, ARHGDIB, ARRB2, IL12A, CEBPE, ITGB3, TIMP3, EBI3, CACNA1B, IL4R, PARK2, FOS, AHR, CHAF1B, NOTCH1, GZMA, CREB3, ADRB2, GTF2H1, RFX1, DDIT3, NMI, VAV1, GRM1, HLA-DRA, RPGR, FGF7, MEFV, IFI16, ITGB2, GAB1, MAP3K5, MPZ, ERCC4, TP73, PTPN11, FGF2, PPEF2, MAPK14, GNA12, IL16, ERCC2, PRKDC, FCGR2B, GJA1, CP, AGTR2, RELB, C1QBP, CTSB, TNNT2, CTGF, REN, MBD2, ARRB1, ACTB, GJA8, STAT5A, FABP4, ATP2B2, SMAD3, SELE, GADD45G, TNFRSF1B, IL4, CRYAA, MAPK8, PLD1, CD28, ASIP, RBP4, BCL10, OPRD1, ABCB4, MAPK1, INPPL1, ETS1, HNF4A, IL27RA, CREBBP, ANKRD1, ATOX1, SH2D1A, PDZK1, PPARG, EGFR, NPM1, PMP22, ACHE, ACCN2, PPARGC1A, CASP3, MAP3K4, HSP90AA1, HCLS1, ELA2, CCR1, FOSL1, ABL1, CHAF1A, CD74, APP, NCF2, TRH, HIF1A, PTGS2, EP300, LCP2, PRKCA, C1QA, CDC2, CADM1, LIPE, CITED2, CCR3, PYCARD, SERPIND1, PSMB9, FGR, STAT3, PLA2G7, PAX5, INSIG2, MIF, FER, RAG2, CTSG, TRAF6, IRF8, IRF2, TP53, SMAD7, LCK, CAMP, PLAU, FANCA, RAC1, RAD52, APOH, XAB2, F11R, CR2, TRPV1, VCP, IRS1, 674 3066 15360 1.3899551121615263 0.003069155053773809 2.6963448490513464E-5 0.0011191935114562845 GOTERM_BP_ALL GO:0007268~synaptic transmission 33 4.67% 4.172744939320199E-6 CTNNB1, DLGAP2, SLC6A1, MAPK1, LIN7A, PHOX2A, NLGN1, HAP1, GRM1, NOS1, PLP1, MPZ, TH, KCNK3, PNOC, PMP22, SNCB, NRXN2, DLG4, ACHE, WNT2, DLG2, STX1A, KIF5A, APBA1, CACNA1B, SNAP25, GABARAPL2, PARK2, ACCN1, CAMK4, AKAP5, HOMER1, 674 304 15360 2.4738403873184445 0.02168507115875018 1.6482587075572486E-4 0.0079820961009891 GOTERM_BP_ALL GO:0007267~cell-cell signaling 63 8.92% 1.1335294155182107E-8 ASIP, FGF8, MAPK1, LIN7A, HAP1, NOS1, IAPP, SH2D1A, FZD1, PCSK2, KCNK3, NR5A1, PMP22, GJA3, SNCB, NRXN2, DLG4, CCL8, ACHE, WNT2, CCR1, CACNA1B, PARK2, GLI1, MME, LNPEP, SCG5, TRH, CAMK4, HOMER1, ADCYAP1, CTNNB1, VIPR2, SLC6A1, DLGAP2, PHOX2A, C1QA, NLGN1, GRM1, FGF7, PLP1, ITGB2, GRAP2, PCSK1, MPZ, SALL1, ERBB2, EFNA2, TH, FGF2, PNOC, AR, GRN, GJA1, DLG2, STX1A, KIF5A, APBA1, FGF1, SNAP25, GABARAPL2, ACCN1, AKAP5, 674 661 15360 2.1720529545648395 5.955386238820637E-5 6.269012328141699E-7 2.1684244233544092E-5 GOTERM_BP_ALL GO:0007254~JNK cascade 13 1.84% 2.972487264478529E-5 CARD9, MAP3K4, SH2D3C, EDA2R, PAK1, GAB1, MAP3K5, DAXX, MAPK8IP1, MAPK8, MAP3K7, CRKL, MDFI, 674 67 15360 4.421807874573719 0.14459206088064347 9.635897825883699E-4 0.05684791291763469 GOTERM_BP_ALL GO:0050870~positive regulation of T cell activation 10 1.42% 1.2112558905043197E-4 CD28, EBI3, LCK, STAT5A, TRAF6, BCL10, IL4, NCK1, MAP3K7, IL12A, 674 45 15360 5.064292779426311 0.4708230424707437 0.0036095629326022838 0.2314571801061982 GOTERM_BP_ALL GO:0016070~RNA metabolic process 183 25.92% 1.2809386665927661E-6 MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, UPF1, HMGB1, NRF1, RYBP, CIITA, IKBKAP, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, SRPK1, NOTCH1, SMAD1, HCFC1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, NMI, ASCC2, SAFB, IFI16, NRIP1, ORC2L, GSPT2, TP73, EXOSC4, AR, CARM1, ERCC2, HOXB9, EXOSC1, CCNT1, RELB, RFXAP, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PAX3, DACH1, SMAD3, TNFRSF1B, IL4, SREBF2, TCF4, RUNX1T1, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, NEUROD1, MYF5, DDX5, SMARCA4, U2AF2, PPARG, TRIP4, HOXC8, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, TCEA2, PPARGC1A, HCLS1, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, PABPC1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, COPS5, ASCL1, PAX2, SOX10, XAB2, WT1, NCOA2, 674 3020 15360 1.380942087370055 0.00670745995673816 5.516287244500262E-5 0.002450387865449155 GOTERM_BP_ALL GO:0022403~cell cycle phase 29 4.11% 0.0020592510096663955 CD28, CDC25A, PPP5C, KPNA2, CDC2, CALR, E2F1, GSPT2, CDK3, AKAP8, DNM2, NEK2, CDKN3, PRM1, TAF1, CDK2, ANAPC10, TP53, FOSL1, ABL1, CDC6, RCC1, TTN, RB1, UBE2I, MDM2, RAD52, CRYAA, NEDD9, 674 356 15360 1.856433167739139 0.9999802124964581 0.04110962935015283 3.866638543619616 GOTERM_BP_ALL GO:0022402~cell cycle process 81 11.47% 8.297460137333905E-14 CD28, CDC25A, PPP5C, KPNA2, BCL10, CDK5R2, RAP1A, FGF8, CALR, CDC14A, STAT1, BIN1, CDK3, AKAP8, NEK2, EGFR, NPM1, CDKN3, PRM1, TAF1, AXIN1, CDK2, ANAPC10, CASP3, APC2, ZBTB17, FOSL1, ABL1, TTN, RCC1, ACPP, RB1, UBE2I, MOS, SRPK1, C13orf15, HCFC1, DUSP6, ADCYAP1, NEDD9, GTF2H1, PRKCA, DDIT3, CDC2, CADM1, CITED2, PYCARD, MDM4, FGF7, IGF1R, RBL1, E2F1, GSPT2, TP73, FRK, FGF2, PTPN11, DNM2, AXL, ERCC2, MYC, CDC45L, CCNT1, TP53, ZMYND11, E2F2, STARD13, CDC6, FGF1, LCK, DAXX, STAT5A, MDM2, HIC1, RAD52, GADD45G, COPS5, CRYAA, WT1, EPHB2, PLEKHO1, 674 749 15360 2.464532333913071 4.3573344932212876E-10 9.27091736713237E-12 1.5865087021893487E-10 GOTERM_BP_ALL GO:0050865~regulation of cell activation 15 2.12% 2.6746328039159948E-5 CD28, BCL10, TRAF6, CASP3, NCK1, IL27RA, IL12A, CD74, LCK, EBI3, STAT5A, ERBB2, MIF, IL4, MAP3K7, 674 88 15360 3.8845427569463182 0.1310998711253566 8.724582353589749E-4 0.05115291817827661 GOTERM_BP_ALL GO:0007249~I-kappaB kinase/NF-kappaB cascade 17 2.41% 3.2832129382740627E-4 PPP5C, BCL10, TRAF6, GJA1, IKBKG, CARD9, NFKBIA, OTUD7B, CASP1, MAP3K3, REL, CASP8, STAT1, RHOH, TRAF3IP2, MAP3K7, TICAM1, 674 137 15360 2.8278715155190715 0.8218774205127956 0.008808581857795983 0.6262078972376295 GOTERM_BP_ALL GO:0007243~protein kinase cascade 62 8.78% 2.74242906172496E-18 KIT, PPP5C, FGFR1, BCL10, IKBKG, MAPK1, CAV3, SRC, NFKBIA, MARK1, REL, EDA2R, STAT1, MAP2K7, FYN, RHOH, MAP3K7, CRKL, TICAM1, PLCE1, MAP3K4, HCLS1, ADRA2A, OTUD7B, CASP1, IL12A, SH2D3C, SRPK1, SNF1LK2, SMAD1, TRAF3IP2, DUSP6, MDFI, ADRB2, PRKCA, TEC, NMI, GRM1, MAP3K3, PAK1, STAT3, GAB1, CASP8, MAP3K5, FGF2, PTPN11, MAP3K7IP1, MAPK14, GNA12, BLK, TRAF6, GJA1, CARD9, REN, DAXX, STAT5A, CAV1, GADD45G, MAPK8IP1, IL4, MAPK8, IRS1, 674 393 15360 3.59526128615761 1.4408722290302938E-14 4.3662794819099816E-16 5.246225366257647E-15 GOTERM_BP_ALL GO:0050863~regulation of T cell activation 11 1.56% 4.3387575247896376E-4 CD28, EBI3, LCK, STAT5A, TRAF6, BCL10, ERBB2, IL4, NCK1, MAP3K7, IL12A, 674 64 15360 3.9169139465875373 0.8977237583111526 0.011114623369340881 0.8267414098207082 GOTERM_BP_ALL GO:0007242~intracellular signaling cascade 153 21.67% 3.315593033523461E-24 KIT, PPP5C, RAP1A, IKBKG, CAV3, SRC, GZMB, NFKBIA, PTPN6, FHL2, PLCD1, STAT1, CAP1, RALA, MAP2K7, TAX1BP3, FYN, PRKCG, YWHAE, MAP3K7, TICAM1, PLCE1, PRKD3, SNX19, ADRA2A, OTUD7B, DFFA, ARHGDIB, IL12A, RGS19, GNAI3, ELMO1, CA8, S100A1, CHN1, SRPK1, SNF1LK2, SMAD1, GZMA, TRAF3IP2, GNB2L1, DUSP6, HOMER1, ADRB2, DDIT3, NMI, VAV1, GRM1, MAP3K3, NRIP1, GRAP2, PRKCE, GAB1, MAP3K5, ERBB2, FRK, FGF2, PTPN11, MAP3K7IP1, MAPK14, CASP2, GNA12, ARHGEF9, GJA1, CTGF, REN, CRK, STAT5A, PICK1, RAC3, CAV1, SMAD3, GADD45G, IL4, MAPK8, PLD1, ASIP, FGFR1, BCL10, OPRD1, MAPK1, INPPL1, MARK1, INADL, REL, EDA2R, SH2D1A, GRB7, RHOH, EGFR, RND1, CRKL, PPARGC1A, CASP3, MAP3K4, HCLS1, ZBTB33, PIK3R1, CCR1, CASP1, DCX, ABL1, SH2D3C, RB1, TRH, RAF1, MDFI, ADCYAP1, FES, CTNNB1, SIAH2, LCP2, PRKCA, BCL2L1, LIMK1, TEC, CBLC, RASA2, CCR3, PYCARD, PRKAR2A, SHC2, SLA, PAK1, STAT3, CASP8, FGR, DFFB, FER, BLK, SMAD2, NCOA1, TRAF6, OPRL1, HCK, FGD1, CARD9, TP53, NCK1, ROPN1B, LCK, DAXX, PLCG1, ARF1, RAC1, TGFB1I1, MAPK8IP1, AKAP13, PARD3, VCP, IRS1, CBL, NCOA2, 674 1496 15360 2.3307256541677908 1.7420125798132263E-20 1.0887578623832664E-21 6.342679385740265E-21 GOTERM_BP_ALL GO:0009653~anatomical structure morphogenesis 104 14.73% 5.608188121265214E-13 KCNJ8, FGF8, BAI1, CAP1, PLG, MMP14, FYN, WNT1, MAP3K7, S100A7, PLCE1, WNT2, POU1F1, KLF1, DAG1, NOTCH1, BRSK2, IGFBP3, NTS, EYA1, GCM1, CLTCL1, NEDD9, ADRB2, NOV, ITGB2, ERBB2, TP73, FGF2, PTPN11, MAP3K7IP1, AR, GNA12, ERCC2, GJA1, AGTR2, JUN, CTGF, FGF1, PTPRZ1, DYNLL1, STAT5A, PAX3, CAV1, ATP2B2, RAC3, SMAD3, SPTA1, BCL10, FGFR1, MAPK1, LHX3, DCN, IGFBP5, DDX5, MYF5, FZD1, PPARG, CRKL, SMAD4, RNF2, NOTCH4, ZBTB16, AKAP2, CSPG4, RB1, GLI1, EP300, CD44, ACTN2, EPB42, CTNNB1, LIMK1, TLX1, DLX5, SRF, IGF1R, BMPR1A, PARD6B, TWIST1, CASP8, SALL1, TH, PAX5, SFRP1, SMAD2, TIE1, PRKG1, FGD1, TP53, ACTC1, NCK1, ZEB2, HAND1, CDK5, HAND2, SIX1, POU3F2, RAC1, KDR, SOX10, PAX2, F11R, PARD3, 674 1133 15360 2.091870274290833 2.946304755724327E-9 5.35691491165835E-11 1.0727529975440575E-9 GOTERM_BP_ALL GO:0022008~neurogenesis 30 4.25% 1.1428151764240696E-4 LIMK1, TLX1, DLX5, NLGN1, BAI1, PARD6B, TWIST1, MMP14, SMARCA4, FYN, FGF2, PTPN11, HOXC8, RND1, PRKG1, GJA1, WNT2, PTPRZ1, GATA2, CDK5, APP, PICK1, ATP2B2, SIX1, POU3F2, BRSK2, ASCL1, PAX2, PARD3, GCM1, 674 312 15360 2.1912805295594615 0.4514459187209292 0.003445025829989734 0.21839248567140368 GOTERM_BP_ALL GO:0000902~cell morphogenesis 42 5.95% 8.315072384032248E-5 SPTA1, ACTN2, EPB42, CTNNB1, FGFR1, LIMK1, DLX5, BAI1, NOV, PARD6B, ITGB2, IGFBP5, CAP1, DDX5, TP73, FYN, WNT1, PTPN11, AR, GNA12, SMAD4, PLCE1, PRKG1, GJA1, FGD1, TP53, NCK1, CTGF, AKAP2, PTPRZ1, CDK5, RB1, RAC3, ATP2B2, POU3F2, RAC1, SMAD3, BRSK2, PAX2, IGFBP3, PARD3, NEDD9, 674 499 15360 1.9181389485201858 0.3539588433566896 0.002551663328472231 0.15894623862988677 GOTERM_BP_ALL GO:0046651~lymphocyte proliferation 10 1.42% 0.003362023688914717 CD28, EBI3, STAT5A, ERBB2, TNFRSF14, CASP3, CADM1, IL4, NCK1, IL12A, 674 70 15360 3.255616786774057 0.9999999793144966 0.06275688934389234 6.239203256175152 GOTERM_BP_ALL GO:0016055~Wnt receptor signaling pathway 18 2.55% 3.5171511927177135E-5 AXIN1, CTNNB1, WNT2, APC2, SLC9A3R1, ZBTB33, DIXDC1, CSNK2B, SIX3, CSNK1A1, LRP1, CSNK2A1, TAX1BP3, FZD1, TGFB1I1, WNT1, SFRP1, MDFI, 674 126 15360 3.2556167867740564 0.1687248014558309 0.0011330654085620617 0.06726112379478177 GOTERM_BP_ALL GO:0046649~lymphocyte activation 25 3.54% 1.8767710981651515E-6 CD28, BCL10, CADM1, VAV1, IL27RA, TNFRSF14, ERBB2, RHOH, RAG1, MAP3K7, NTRK1, RAG2, TRAF6, CASP3, RELB, PIK3R1, NCK1, IL12A, CD74, LCK, EBI3, SLAMF1, STAT5A, SMAD3, IL4, 674 185 15360 3.0796375010024857 0.009812108634319916 7.82553871171432E-5 0.0035901736799459627 GOTERM_BP_ALL GO:0042129~regulation of T cell proliferation 7 0.99% 0.00438029423517078 CD28, EBI3, STAT5A, ERBB2, IL4, NCK1, IL12A, 674 36 15360 4.431256181998021 0.9999999999038025 0.07774035406580082 8.054890850895646 GOTERM_BP_ALL GO:0042127~regulation of cell proliferation 63 8.92% 8.7457386499374E-14 CD28, KIT, FGFR1, BAI1, NFKBIA, PTPN6, ETS1, PLG, BTC, EGFR, NPM1, CDKN3, PAWR, PMP22, SMAD4, DBP, HTR1A, CDK2, WNT2, CASP3, POU1F1, HCLS1, ELA2, ADRA2A, ZBTB16, FOSL1, IL12A, RB1, EBI3, SLAMF1, GLI1, NOTCH1, PTGS2, SMAD1, ADRB2, CTNNB1, TLX1, ABI1, MDM4, FGF7, IGF1R, BMPR1A, CTBP1, ERBB2, CAPN1, FRK, FGF2, MYC, GRN, LAMA1, GJA1, TP53, NCK1, CDC6, LIFR, FOXO1, STAT5A, MDM2, CAV1, POU3F2, TGFB1I1, SMAD3, IL4, 674 499 15360 2.8772084227802783 4.596492075847891E-10 9.576006654299363E-12 1.673550187319961E-10 GOTERM_BP_ALL GO:0050852~T cell receptor signaling pathway 6 0.85% 8.465856751736316E-4 LCK, TRAF6, BCL10, IKBKG, FYN, MAP3K7, 674 18 15360 7.596439169139466 0.9883196226034697 0.01949700580275493 1.6071370147797581 GOTERM_BP_ALL GO:0016044~membrane organization and biogenesis 31 4.39% 1.62428533279224E-5 SERPINA5, BCL2L1, CAV3, VAV1, NLGN1, LMNA, SYP, SNX17, CAP1, BIN1, DNM2, EGFR, ATG7, TIE1, SLC9A3, TP53, ELA2, SH3GL2, CEBPE, GATA2, ELMO1, ROPN1B, CUBN, APP, LRP1, LRP2, PICK1, RAC1, CBL, CLTCL1, ADRB2, 674 295 15360 2.3948096363727807 0.0818005484475598 5.540065107454417E-4 0.03106775836830833 GOTERM_BP_ALL GO:0016043~cellular component organization and biogenesis 214 30.31% 1.141717259494342E-19 TUBA3C, GZMB, BAI1, NFKBIA, HAP1, CAP1, STAT1, FHOD1, UPF1, STXBP1, HMGB1, FYN, PRM1, ATG7, PLCE1, EXOC2, POU1F1, DOCK2, SLC9A3R1, ADRA2A, DFFA, RCC1, CACNA1B, CLTCL1, NEDD9, VAV1, NLGN1, RPGR, ITGB2, HIST3H3, MPZ, TRPV6, PTPN11, EXOSC4, CARM1, GJA1, E2F2, MBD2, PTPRZ1, CUBN, PICK1, GTF2F2, ATP2B2, CAV1, WRN, SLC9A3R2, MMP9, SPTA1, BCL10, KPNA2, IGFBP5, SMARCA4, DDX5, NRXN2, CBX2, RNF2, MPP6, EPB41L3, HSP90AA1, ELA2, TAF13, AKAP2, CD74, RB1, APP, SCG5, RAF1, EP300, MDFI, LASP1, SORBS1, MAGI1, ACTN2, EPB42, LCP2, CADM1, DLX5, MDM4, IGF1R, PEX6, PCGF2, ERC2, DFFB, CBX1, PRKG1, SETDB1, ACTC1, TRAF1, PEX19, GATA2, CDK5, SHANK1, MDM2, ARF1, FANCA, POU3F2, RAC1, PAX2, AKAP5, MICAL1, CBL, PEX26, CAV3, SRC, LMNA, SYP, SNX17, BIN1, WNT1, AKAP8, NEK2, ATP7B, DLG4, IKBKAP, CCL8, WNT2, PTK2, ARHGDIB, KLF1, TTN, CEBPE, ITGB3, ELMO1, DAG1, LRP1, PXN, PARK2, CHAF1B, BRSK2, CAMK4, IGFBP3, GZMA, HCFC1, ADRB2, GFAP, AKAP3, NOV, SAFB, TJP1, ERCC4, ATG12, TP73, DNM2, AR, SYNPO, ABLIM3, GNA12, EXOSC1, ATG5, TNNT2, CTGF, TUBA1A, HDAC1, ACTB, CRK, DYNLL1, GABARAPL2, SNAP25, SGCG, RAC3, SMAD3, KIFAP3, CRYAA, FGFR1, LIN7A, KRT8, MARK1, CALR, CREBBP, PDE4DIP, MYF5, KIFC3, EGFR, RND1, NPM1, SMAD4, TAF1, ACHE, CASP3, PPARGC1A, APC2, ABL1, CHD1, VIM, CHAF1A, LRP2, TBP, SERPINA5, CTNNB1, LIMK1, BCL2L1, PYCARD, KISS1, RBL1, PARD6B, PAK1, NCOR1, MYH4, STX12, WIPF1, EXOC3, TIE1, STX1A, FGD1, SLC9A3, TP53, SH3GL2, NCK1, KIF5A, APBA1, ROPN1B, YWHAZ, PARD3, VCP, 674 2723 15360 1.791007692466962 5.998582481383273E-16 2.221697215327138E-17 2.1840878699286817E-16 GOTERM_BP_ALL GO:0042110~T cell activation 19 2.69% 3.219129807322406E-6 CD28, RAG2, BCL10, TRAF6, RELB, VAV1, CADM1, NCK1, IL12A, CD74, LCK, EBI3, STAT5A, ERBB2, TNFRSF14, SMAD3, RHOH, IL4, MAP3K7, 674 117 15360 3.7008293388115345 0.016771107752126757 1.3009411572306728E-4 0.006157966992548225 GOTERM_BP_ALL GO:0009628~response to abiotic stimulus 17 2.41% 0.003104784537454787 KIT, GJA1, TRPC3, KCNJ8, ACCN2, ELA2, IL12A, MPZ, MMP14, PDC, ERCC4, ATP2B2, MAPK8, PMP22, TRPV1, ERCC2, ADRB2, 674 169 15360 2.292416554000667 0.9999999197335375 0.05871638977311533 5.775170218179337 GOTERM_BP_ALL GO:0042102~positive regulation of T cell proliferation 6 0.85% 0.005757264771224822 CD28, EBI3, STAT5A, IL4, NCK1, IL12A, 674 27 15360 5.064292779426311 0.9999999999999332 0.09617567227858337 10.457236235814305 GOTERM_BP_ALL GO:0042098~T cell proliferation 9 1.27% 0.0013697867646357248 CD28, EBI3, STAT5A, ERBB2, TNFRSF14, CADM1, IL4, NCK1, IL12A, 674 50 15360 4.102077151335311 0.9992547518060133 0.029321023164449733 2.588097164566394 GOTERM_BP_ALL GO:0009611~response to wounding 38 5.38% 7.573559934541757E-5 CXCL2, PRKCA, C1QA, NMI, CCR3, PYCARD, SERPIND1, FGF7, PTPN6, HNF4A, MEFV, ITGB2, STAT3, PLG, PLA2G7, MIF, PLAT, GNA12, CCL8, ACHE, CASP3, ELA2, CTSB, CCR1, CTGF, ITGB3, STAT5A, FOS, PLAU, FABP4, RAC1, SELE, TNFRSF1B, APOH, PTGS2, F11R, CR2, ADRB2, 674 431 15360 2.009266972811831 0.32829089247316445 0.002351844908477063 0.14478163416263845 GOTERM_BP_ALL GO:0006139~nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 220 31.16% 1.5673671534504067E-4 PPP5C, MAFK, GATA4, POU2AF1, CRY1, STAT1, UPF1, HMGB1, NRF1, PRM1, RAG1, PRKCG, POU1F1, ZBTB17, RFXANK, DFFA, RCC1, FOXH1, SRY, AHR, ID2, SRPK1, SUB1, GCM1, GTF2H1, MAX, DDIT3, PHOX2A, NRIP1, HIST3H3, GSPT2, DNMT3A, PPFIBP2, EXOSC4, CARM1, PRKDC, HOXB9, RELB, RFXAP, ATF7IP2, E2F2, JUN, ZNF208, MBD2, HOXB7, PICK1, GTF2F2, PAX3, TNFRSF1B, WRN, GADD45G, IL4, SREBF2, TCF4, BCL10, KPNA2, MAPK1, HNF4A, IL27RA, REL, EDA2R, SMARCA4, DDX5, U2AF2, HOXC8, NR5A1, RXRG, CBX2, RNF2, DBP, TCEA2, ZBTB16, FOSL1, TAF13, RB1, APP, GLI1, EP300, MDFI, DLGAP2, TLX1, DLX5, MDM4, SRF, TWIST1, MYF6, STAT3, SALL1, PCGF2, HOXB2, PAX5, PABPC1, DFFB, CBX1, POLR2A, SMAD2, NCOA1, IRF8, SETDB1, IRF2, HOXD10, ZEB2, GATA2, SMAD7, HAND2, FOXO1, DAXX, MDM2, FANCA, SIX1, POU3F2, TGFB1I1, SOX10, PAX2, XAB2, WT1, IKBKG, PER1, MEOX1, FHL2, MEOX2, YBX1, PARP1, RYBP, CIITA, IKBKAP, CDK2, PPARA, KLF1, CEBPE, FOS, SP4, CHAF1B, HOXD4, NOTCH1, SMAD1, HCFC1, EYA1, CREB3, ADRB2, RFX1, NMI, ASCC2, IFI16, SAFB, ORC2L, ERCC4, TP73, DNM2, AR, ERCC2, EXOSC1, CCNT1, CDC6, CTGF, HDAC1, CRK, STAT5A, DACH1, FABP4, SMAD3, RUNX1T1, LHX3, TAL1, CALR, ETS1, CREBBP, NEUROD1, ANKRD1, MYF5, FZD1, RHOH, PPARG, TRIP4, NPM1, PAWR, HEYL, SMAD4, NOTCH4, TAF1, ACHE, PPARGC1A, HCLS1, ZBTB33, CHD1, ABL1, CHAF1A, HOXA9, EAF2, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, CTNNB1, HOXA5, CITED2, PYCARD, RBL1, E2F1, NCOR1, NFE2, MYC, MIZF, RAG2, CDC45L, PDE4D, MEIS1, TP53, ZMYND11, HAND1, SIX3, ZNF423, HIC1, RAD52, COPS5, ASCL1, VCP, NCOA2, 674 4051 15360 1.2376326466630578 0.5611331632627004 0.004514828179962405 0.2994093422437061 GOTERM_BP_ALL GO:0032147~activation of protein kinase activity 13 1.84% 1.3083259271535014E-5 TRAF6, IKBKG, PRKD3, MAP3K4, GRM1, PICK1, FGF2, GADD45G, MAP3K7IP1, GNB2L1, MAP3K7, PARD3, PLCE1, 674 62 15360 4.778405283813535 0.06643052436958075 4.521339006250402E-4 0.025025109265508494 GOTERM_BP_ALL GO:0065009~regulation of a molecular function 66 9.35% 3.149250775142262E-13 CDC25A, KIT, BCL10, CDK5R2, IKBKG, CAV3, NFKBIA, EDA2R, STAT1, CAP1, EGFR, NPM1, CDKN3, MAP3K7, SMAD4, PLCE1, CASP3, MAP3K4, PRKD3, ELA2, SLC9A3R1, ADRA2A, ABL1, GNAI3, RB1, ID2, CAMK2A, C13orf15, GNB2L1, EP300, DUSP6, MDFI, ADRB2, ADCYAP1, GTF2H1, PRKCA, DDIT3, VAV1, CBLC, GRM1, PYCARD, RBL1, GAB1, MAP3K5, ERBB2, FGF2, PTPN11, MAP3K7IP1, SMAD2, TRAF6, CCNT1, FGD1, TP53, CTSB, TNNT2, CDC6, LCK, DAXX, PICK1, FABP4, CAV1, SMAD3, GADD45G, PARD3, VCP, IRS1, 674 554 15360 2.7149728438440692 1.6548538095406684E-9 3.0645486148728196E-11 6.025291376943187E-10 GOTERM_BP_ALL GO:0065008~regulation of biological quality 82 11.61% 1.3671149555829007E-10 SPTA1, FGFR1, BCL10, KCNJ8, IKBKG, CAV3, HNF4A, CALR, CREBBP, SLC9A1, IAPP, ATOX1, IGFBP5, PLG, DDX5, PLAT, SMAD4, ATP7B, PLCE1, WNT2, PPARGC1A, CASP3, ELA2, SLC9A3R1, CCR1, SLC22A2, ITGB3, RB1, CACNA1B, APP, SLC34A1, HIF1A, PTGS2, SMAD1, IGFBP3, NTS, EP300, ADRB2, NEDD9, CTNNB1, PRKCA, DDIT3, BCL2L1, CCR3, MDM4, SERPIND1, SRF, NOV, PLP1, KCNA5, PEX6, CSRP3, MPZ, ERBB2, TP73, PABPC1, NFE2, STX12, AR, GNA12, MYC, CP, OPRL1, AGTR2, SLC9A3, TP53, NCK1, CTGF, REN, IREB2, LCK, CUBN, STAT5A, PLAU, FABP4, CAV1, ATP2B2, SMAD3, TNFRSF1B, PLN, APOH, TRPV1, 674 881 15360 2.121139654492972 7.182821258888694E-7 1.0883066337008529E-8 2.615270888739474E-7 GOTERM_BP_ALL GO:0050801~ion homeostasis 23 3.26% 7.103494379038447E-4 CP, OPRL1, PRKCA, BCL2L1, CAV3, SLC9A3, ELA2, SLC9A3R1, CCR1, CCR3, CALR, KCNA5, IREB2, SLC9A1, CSRP3, LCK, ATOX1, APP, ATP2B2, PLN, ATP7B, MYC, PLCE1, 674 236 15360 2.220992807926369 0.9760910436931881 0.016903460909670875 1.3501728968422166 GOTERM_BP_ALL GO:0065007~biological regulation 398 56.37% 1.0390221454146694E-41 KIT, PPP5C, KCNJ8, NFKBIA, BAI1, PTPN6, CRY1, MMP14, CDK3, HMGB1, NRF1, FYN, PRKCG, ATG7, TICAM1, PLCE1, PRKD3, RFXANK, RCC1, SLC34A1, AHR, ID2, C13orf15, NTS, SUB1, GCM1, GTF2H1, MAX, DDIT3, VAV1, RGS2, ABI1, ITGB2, NRIP1, PRKCE, MAP3K5, CTBP1, MPZ, TRPV6, CARM1, HOXB9, CP, RELB, ATF7IP2, E2F2, CTSB, JUN, ARRB1, FGF1, HOXB7, PICK1, PAX3, CAV1, ATP2B2, MMP9, CDC25A, BCL10, HNF4A, IL27RA, REL, EDA2R, IGFBP5, BTC, SMARCA4, NR5A1, PMP22, SNCB, CBX2, RNF2, ANAPC10, HSP90AA1, ELA2, FOSL1, TAF13, AKAP2, RB1, EP300, EPB42, DLGAP2, CADM1, DLX5, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, CAPN1, TH, MIF, GRN, PRKG1, OPRL1, IRF8, SETDB1, IRF2, ACTC1, HOXD10, ZEB2, GATA2, FOXO1, DAXX, TGFB1I1, APOH, AKAP13, CBL, IKBKG, CAV3, CDC14A, SNX17, BIN1, PLG, NEK2, RYBP, CDKN3, MAP3K7, ATP7B, CIITA, HTR1A, GNAI3, CEBPE, FOS, NOTCH1, SMAD1, IGFBP3, DUSP6, EYA1, ASCC2, PLP1, IFI16, SAFB, CSRP3, ORC2L, ERCC4, FGF2, AXL, AR, CASP2, IL16, ERCC2, ARHGEF9, CDC6, HDAC1, DACH1, SMAD3, MAPK8, EPHB2, LIN7A, LHX3, CALR, NEUROD1, FZD1, RHOH, EGFR, KCNJ12, SEPT4, ACHE, CASP3, PPARGC1A, PIK3R1, TRAIP, MYOG, TBP, HIF1A, CAMK2A, LIMK1, BCL2L1, CBLC, CITED2, CCR3, RBL1, E2F1, NCOR1, MIZF, TIE1, TRAF6, CDC45L, STARD13, HAND1, SIX3, LCK, PLAU, ZNF423, PARD3, NCOA2, CDK5R2, MAFK, FGF8, GATA4, POU2AF1, CAP1, STAT1, UPF1, PLAT, POU1F1, ZBTB17, SLC9A3R1, ADRA2A, OTUD7B, TIMP3, CACNA1B, ADRBK1, FOXH1, EBI3, SRY, SRPK1, GNB2L1, CASP5, NEDD9, PHOX2A, SERPINB2, NLGN1, GRM1, MAP3K3, GAB1, DNMT3A, PTPN11, LAMA1, GJA1, AGTR2, ZNF208, MBD2, CUBN, GTF2F2, TNFRSF1B, WRN, GADD45G, IL4, SREBF2, TCF4, PLEKHO1, SPTA1, KPNA2, MAPK1, SLC9A1, DDX5, HOXC8, RXRG, NRXN2, DBP, TCEA2, CCR1, ZBTB16, CD74, SLAMF1, APP, GLI1, MOS, SCG5, PTGS2, MDFI, LMO2, ADCYAP1, ACTN2, CDC2, C1QA, RASA2, TLX1, SRF, ACTN3, MYF6, PEX6, SCN5A, CASP8, SALL1, CHRM3, PCGF2, HOXB2, PAX5, PABPC1, SFRP1, POLR2A, SMAD2, NCOA1, CARD9, TRAF1, CDK5, SMAD7, HAND2, MDM2, SIX1, POU3F2, RAC1, PLN, SOX10, PAX2, TRPV1, WT1, RAP1A, PER1, MEOX1, FHL2, SLC8A1, MEOX2, YBX1, TAX1BP3, LAMA3, IKBKAP, AXIN1, CDK2, WNT2, PPARA, ARHGDIB, KLF1, RGS19, IL12A, ACPP, ITGB3, S100A1, LRP1, PARK2, SP4, CHAF1B, HOXD4, TRAF3, SNF1LK2, TRAF3IP2, HCFC1, CREB3, ADRB2, RFX1, FGF7, NOV, KCNA5, ERBB2, TP73, FRK, DNM2, MAP3K7IP1, GNA12, CCNT1, TNNT2, REN, LIFR, CTGF, CRK, IREB2, SNAP25, STAT5A, FABP4, CRYAA, CD28, RUNX1T1, FGFR1, NAIP, TAL1, ETS1, CREBBP, IAPP, ANKRD1, ATOX1, MYF5, PPARG, TRIP4, RND1, NPM1, HEYL, PAWR, SMAD4, NOTCH4, TAF1, MAP3K4, APC2, HCLS1, ZBTB33, CASP1, ABL1, CHD1, CHAF1A, SLC22A2, HOXA9, EAF2, NHLH1, MYT1, SERPINA5, CTNNB1, PRKCA, HOXA5, PYCARD, SERPIND1, PARD6B, NFE2, STX12, MYC, STX1A, FGD1, MEIS1, SLC9A3, TP53, ZMYND11, NCK1, YWHAZ, HIC1, MAPK8IP1, COPS5, ASCL1, CR2, VCP, IRS1, 674 5238 15360 1.7316052630684464 5.459022352008673E-38 2.729511176004337E-38 1.9876336680699016E-38 GOTERM_BP_ALL GO:0009605~response to external stimulus 63 8.92% 4.248526973473043E-9 CXCL2, TRPC3, MAPK1, PTPN6, HNF4A, PER1, RALA, PLG, MMP14, PDC, PPARG, PMP22, PLAT, DEFB1, CCL8, ACHE, PPARGC1A, CASP3, DOCK2, ELA2, CCR1, FOSL1, ITGB3, FOS, PARK2, PTGS2, CREB3, ADRB2, PRKCA, DDIT3, C1QA, NMI, CCR3, PYCARD, SERPIND1, FGF7, MEFV, ITGB2, STAT3, MPZ, PLA2G7, FGF2, MIF, MAPK14, FER, GNA12, IL16, CP, TP53, CTSB, CTGF, STAT5A, PLAU, FABP4, ATP2B2, SELE, RAC1, TNFRSF1B, APOH, IL4, F11R, CR2, PLD1, 674 644 15360 2.2293897561604954 2.2321511643719205E-5 2.65735211946172E-7 8.127367612242864E-6 GOTERM_BP_ALL GO:0065003~macromolecular complex assembly 49 6.94% 6.875484442541867E-6 BCL10, LIN7A, SRC, CREBBP, HMGB1, NPM1, SMAD4, DLG4, MPP6, IKBKAP, TAF1, PPARGC1A, APC2, SLC9A3R1, PTK2, TAF13, CD74, CHAF1A, DAG1, PXN, CHAF1B, TBP, HCFC1, CLTCL1, MAGI1, ADRB2, ACTN2, MDM4, IGF1R, PARD6B, HIST3H3, TJP1, WIPF1, GJA1, TP53, E2F2, TRAF1, NCK1, MBD2, APBA1, GTF2F2, PICK1, MDM2, CAV1, FANCA, SMAD3, KIFAP3, SLC9A3R2, PARD3, 674 560 15360 1.9940652818991096 0.0354792368014859 2.5436144355728274E-4 0.013151878153772056 GOTERM_BP_ALL GO:0050794~regulation of cellular process 331 46.88% 4.5876222733140175E-30 KIT, PPP5C, MAFK, CDK5R2, FGF8, GATA4, BAI1, NFKBIA, POU2AF1, PTPN6, CRY1, STAT1, MMP14, UPF1, CDK3, HMGB1, NRF1, PRKCG, TICAM1, PLCE1, POU1F1, ZBTB17, ADRA2A, OTUD7B, RFXANK, RCC1, TIMP3, ADRBK1, FOXH1, EBI3, SRY, ID2, AHR, SRPK1, C13orf15, SUB1, CASP5, GCM1, NEDD9, GTF2H1, MAX, DDIT3, PHOX2A, VAV1, RGS2, SERPINB2, ABI1, NLGN1, GRM1, MAP3K3, NRIP1, ITGB2, PRKCE, GAB1, MAP3K5, CTBP1, TRPV6, PTPN11, CARM1, HOXB9, LAMA1, GJA1, RELB, E2F2, ATF7IP2, JUN, CTSB, ZNF208, ARRB1, MBD2, FGF1, HOXB7, GTF2F2, PAX3, CAV1, TNFRSF1B, WRN, GADD45G, IL4, SREBF2, MMP9, TCF4, PLEKHO1, CDC25A, SPTA1, BCL10, KPNA2, MAPK1, HNF4A, REL, EDA2R, IGFBP5, BTC, SMARCA4, HOXC8, NR5A1, PMP22, RXRG, RNF2, CBX2, DBP, ANAPC10, TCEA2, ELA2, ZBTB16, FOSL1, TAF13, CD74, SLAMF1, RB1, APP, GLI1, MOS, PTGS2, EP300, MDFI, LMO2, ADCYAP1, ACTN2, DLGAP2, CDC2, TLX1, RASA2, CADM1, DLX5, MDM4, SRF, IGF1R, ACTN3, BMPR1A, MYF6, TWIST1, CASP8, STAT3, SALL1, PCGF2, CAPN1, PAX5, HOXB2, PABPC1, MIF, SFRP1, POLR2A, GRN, SMAD2, NCOA1, SETDB1, IRF8, CARD9, IRF2, TRAF1, HOXD10, ZEB2, GATA2, HAND2, SMAD7, CDK5, FOXO1, DAXX, MDM2, SIX1, POU3F2, RAC1, TGFB1I1, PLN, PAX2, SOX10, AKAP13, WT1, CBL, RAP1A, IKBKG, CAV3, PER1, FHL2, MEOX1, CDC14A, MEOX2, SNX17, YBX1, BIN1, PLG, TAX1BP3, NEK2, RYBP, CDKN3, MAP3K7, LAMA3, CIITA, IKBKAP, AXIN1, CDK2, HTR1A, WNT2, PPARA, KLF1, ARHGDIB, IL12A, RGS19, CEBPE, ITGB3, ACPP, LRP1, FOS, HOXD4, CHAF1B, SP4, TRAF3, SNF1LK2, NOTCH1, SMAD1, TRAF3IP2, IGFBP3, HCFC1, CREB3, EYA1, DUSP6, ADRB2, RFX1, ASCC2, FGF7, NOV, SAFB, IFI16, ORC2L, ERBB2, ERCC4, TP73, FRK, FGF2, DNM2, AXL, AR, CASP2, ERCC2, ARHGEF9, CCNT1, CDC6, CTGF, LIFR, REN, HDAC1, CRK, STAT5A, DACH1, FABP4, SMAD3, CRYAA, MAPK8, EPHB2, CD28, RUNX1T1, FGFR1, NAIP, TAL1, LHX3, ETS1, CALR, CREBBP, ANKRD1, IAPP, NEUROD1, MYF5, FZD1, PPARG, RHOH, TRIP4, EGFR, NPM1, RND1, PAWR, HEYL, SMAD4, NOTCH4, TAF1, SEPT4, PPARGC1A, CASP3, APC2, HCLS1, ZBTB33, PIK3R1, CASP1, CHD1, ABL1, CHAF1A, HOXA9, EAF2, TRAIP, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, SERPINA5, CTNNB1, HOXA5, PRKCA, BCL2L1, CBLC, CITED2, PYCARD, RBL1, PARD6B, E2F1, NCOR1, NFE2, MYC, MIZF, TIE1, TRAF6, CDC45L, FGD1, MEIS1, SLC9A3, TP53, ZMYND11, STARD13, NCK1, SIX3, HAND1, LCK, YWHAZ, ZNF423, HIC1, MAPK8IP1, COPS5, ASCL1, VCP, NCOA2, 674 4422 15360 1.7058489586059453 2.4103367423991848E-26 3.012920927998981E-27 8.776052105402585E-27 GOTERM_BP_ALL GO:0050793~regulation of developmental process 33 4.67% 1.1734701777047592E-7 SPTA1, EPB42, CTNNB1, LIMK1, MAPK1, DLX5, NLGN1, NFKBIA, ETS1, TWIST1, IAPP, ITGB2, FYN, PPARG, FGF2, GNA12, LAMA3, NOTCH4, LAMA1, FGD1, ZBTB16, AKAP2, RB1, STAT5A, ID2, SIX1, POU3F2, NOTCH1, ASCL1, IL4, IGFBP3, LMO2, ADRB2, 674 259 15360 2.9036582152309154 6.163512450227948E-4 5.928263846377568E-6 2.2448283348852627E-4 GOTERM_BP_ALL GO:0050790~regulation of catalytic activity 55 7.79% 3.261175657327952E-10 KIT, CDC25A, CDK5R2, IKBKG, CAV3, STAT1, CAP1, EGFR, CDKN3, MAP3K7, PLCE1, CASP3, PRKD3, MAP3K4, ELA2, SLC9A3R1, ADRA2A, ABL1, GNAI3, RB1, C13orf15, GNB2L1, DUSP6, MDFI, ADCYAP1, ADRB2, GTF2H1, PRKCA, VAV1, GRM1, PYCARD, RBL1, GAB1, MAP3K5, ERBB2, FGF2, PTPN11, MAP3K7IP1, TRAF6, CCNT1, FGD1, TP53, CTSB, TNNT2, CDC6, LCK, DAXX, PICK1, CAV1, FABP4, SMAD3, GADD45G, PARD3, VCP, IRS1, 674 488 15360 2.568468161696746 1.713420283988576E-6 2.379752406245217E-8 6.238579985939907E-7 GOTERM_BP_ALL GO:0007179~transforming growth factor beta receptor signaling pathway 10 1.42% 3.2892410781967346E-4 SMAD2, FOXH1, SMAD3, CITED2, MAP3K7IP1, SMAD1, MAP3K7, BMPR1A, SMAD4, SMAD7, 674 51 15360 4.468493628905568 0.8224408600533479 0.008779860249859328 0.6273542201295057 GOTERM_BP_ALL GO:0050789~regulation of biological process 365 51.70% 2.777149225547623E-37 KIT, PPP5C, MAFK, CDK5R2, FGF8, GATA4, BAI1, NFKBIA, POU2AF1, PTPN6, CRY1, STAT1, MMP14, UPF1, CDK3, HMGB1, FYN, NRF1, PRKCG, ATG7, TICAM1, PLCE1, POU1F1, ZBTB17, ADRA2A, OTUD7B, RFXANK, RCC1, TIMP3, CACNA1B, ADRBK1, FOXH1, EBI3, SRY, ID2, AHR, SRPK1, C13orf15, SUB1, CASP5, GCM1, NEDD9, GTF2H1, MAX, DDIT3, PHOX2A, RGS2, VAV1, SERPINB2, NLGN1, ABI1, GRM1, MAP3K3, NRIP1, ITGB2, GAB1, PRKCE, MAP3K5, CTBP1, DNMT3A, TRPV6, PTPN11, CARM1, HOXB9, LAMA1, GJA1, RELB, E2F2, ATF7IP2, JUN, CTSB, ZNF208, MBD2, ARRB1, FGF1, HOXB7, GTF2F2, PICK1, PAX3, CAV1, GADD45G, WRN, TNFRSF1B, IL4, SREBF2, TCF4, MMP9, PLEKHO1, SPTA1, CDC25A, KPNA2, BCL10, MAPK1, HNF4A, IL27RA, REL, EDA2R, IGFBP5, BTC, SMARCA4, HOXC8, NR5A1, PMP22, RXRG, SNCB, NRXN2, RNF2, CBX2, DBP, ANAPC10, TCEA2, HSP90AA1, ELA2, ZBTB16, FOSL1, TAF13, AKAP2, CD74, SLAMF1, RB1, APP, GLI1, SCG5, MOS, PTGS2, EP300, MDFI, LMO2, ADCYAP1, ACTN2, EPB42, DLGAP2, C1QA, CDC2, TLX1, RASA2, CADM1, DLX5, MDM4, SRF, IGF1R, ACTN3, BMPR1A, MYF6, TWIST1, CASP8, SCN5A, STAT3, SALL1, CHRM3, PCGF2, TH, CAPN1, PAX5, HOXB2, PABPC1, MIF, SFRP1, POLR2A, GRN, SMAD2, PRKG1, NCOA1, SETDB1, IRF8, CARD9, IRF2, ACTC1, TRAF1, HOXD10, ZEB2, GATA2, HAND2, SMAD7, CDK5, FOXO1, DAXX, MDM2, SIX1, POU3F2, RAC1, TGFB1I1, PLN, APOH, PAX2, SOX10, AKAP13, WT1, CBL, RAP1A, IKBKG, CAV3, PER1, SLC8A1, FHL2, MEOX1, CDC14A, MEOX2, SNX17, YBX1, PLG, BIN1, TAX1BP3, RYBP, NEK2, CDKN3, MAP3K7, LAMA3, CIITA, IKBKAP, AXIN1, CDK2, HTR1A, WNT2, PPARA, KLF1, ARHGDIB, IL12A, RGS19, CEBPE, ITGB3, ACPP, LRP1, S100A1, PARK2, FOS, HOXD4, CHAF1B, SP4, TRAF3, SNF1LK2, NOTCH1, SMAD1, TRAF3IP2, IGFBP3, HCFC1, CREB3, EYA1, DUSP6, ADRB2, RFX1, ASCC2, FGF7, NOV, SAFB, IFI16, CSRP3, ORC2L, ERBB2, ERCC4, TP73, FRK, FGF2, DNM2, AXL, AR, CASP2, GNA12, IL16, ERCC2, ARHGEF9, CCNT1, TNNT2, CDC6, CTGF, LIFR, REN, HDAC1, CRK, SNAP25, STAT5A, DACH1, FABP4, SMAD3, CRYAA, MAPK8, EPHB2, CD28, RUNX1T1, FGFR1, NAIP, LIN7A, TAL1, LHX3, ETS1, CALR, CREBBP, ANKRD1, IAPP, NEUROD1, MYF5, FZD1, PPARG, RHOH, TRIP4, EGFR, NPM1, RND1, PAWR, HEYL, KCNJ12, SMAD4, NOTCH4, TAF1, SEPT4, ACHE, PPARGC1A, CASP3, APC2, HCLS1, ZBTB33, PIK3R1, CASP1, CHD1, ABL1, CHAF1A, HOXA9, EAF2, TRAIP, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, SERPINA5, CTNNB1, HOXA5, PRKCA, BCL2L1, LIMK1, CBLC, CITED2, PYCARD, RBL1, PARD6B, E2F1, NCOR1, NFE2, MYC, MIZF, TIE1, TRAF6, CDC45L, STX1A, FGD1, MEIS1, SLC9A3, TP53, ZMYND11, STARD13, NCK1, SIX3, HAND1, LCK, YWHAZ, PLAU, ZNF423, HIC1, MAPK8IP1, COPS5, ASCL1, CR2, VCP, NCOA2, 674 4759 15360 1.7478673860491103 1.4591142031027211E-33 4.863714010342404E-34 5.312644515146226E-34 GOTERM_BP_ALL GO:0007178~transmembrane receptor protein serine/threonine kinase signaling pathway 11 1.56% 0.0020822729517433916 SMAD2, FOXH1, AKAP3, SMAD3, CITED2, MAP3K7IP1, SMAD1, MAP3K7, BMPR1A, SMAD4, SMAD7, 674 78 15360 3.2138781100205436 0.9999824712511047 0.041402915162813025 3.909054772196663 GOTERM_BP_ALL GO:0044267~cellular protein metabolic process 207 29.32% 7.012467179828245E-7 KIT, PPP5C, CAPN3, TUBA3C, GZMB, PTPN6, CRY1, STAT1, UPF1, MMP14, MAP2K7, CDK3, PPEF1, FYN, PRKCG, ATG7, PLAT, PRKD3, OTUD7B, ADRBK1, EBI3, MAP3K14, SRPK1, CASP5, USP2, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, CSNK1A1, MAP3K5, CTBP1, GSPT2, CSNK2A1, PTPN11, PPEF2, CARM1, PTPRT, PRKDC, CTSB, JUN, MBD2, PTPRZ1, PICK1, IL4, MMP3, MMP9, FGFR4, CDC25A, SPTA1, BCL10, GSK3A, MAPK1, REL, USP9X, CRKL, RNF2, ANAPC10, HSP90AA1, ELA2, EPHB1, ZBTB16, MOS, SCG5, RAF1, EP300, ACP1, EPB42, BMP1, SIAH2, CDC2, C1QA, LIPE, HK3, MDM4, MMP7, PRKAR2A, IGF1R, NSF, BMPR1A, PEX6, CASP8, FGR, PCSK1, CHRM3, CAPN1, PCGF2, FER, NTRK1, BLK, PTPRN, PRKG1, CTSG, HCK, CDK5, MDM2, MAP3K8, RAC1, CBL, DYRK1A, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, PARP1, PCSK2, NEK2, CTSS, CDKN3, MAP3K7, ALK, IKBKAP, NUAK1, CDK2, WNT2, PTK2, TTN, CEBPE, IL12A, UBE2I, PXN, PARK2, SNF1LK2, BRSK2, CAMK4, IGFBP3, GZMA, PRKACA, DUSP6, ADRB2, PTPRH, CASK, ERBB2, ATG12, FGF2, FRK, AXL, MAPK14, CASP2, EPHA3, CTSF, CCNT1, VCPIP1, REN, TUBA1A, HDAC1, STAT5A, SMAD3, MAPK8, GNA14, CRYAA, EPHB2, CD28, FGFR1, MARK1, CALR, CREBBP, ATOX1, PDE4DIP, EGFR, SMAD4, TAF1, ACHE, CASP3, PPARGC1A, MAP3K4, ROS1, HCLS1, PIK3R1, CASP1, ABL1, CHAF1A, LRP2, MME, LNPEP, CAMK2A, MYT1, NEDD4, SERPINA5, FES, LIMK1, PRKCA, PFTK1, TEC, CBLC, PYCARD, PSMB9, PAK1, STAMBPL1, PPP1CA, STX12, TIE1, TRAF6, PTPRS, TP53, NCK1, CSF1R, LCK, PLAU, COPS5, KDR, CR2, VCP, NTRK2, 674 3482 15360 1.3547928558402091 0.0036775726529998387 3.203732634460277E-5 0.001341465850734913 GOTERM_BP_ALL GO:0007172~signal complex assembly 5 0.71% 9.41758474730025E-4 PICK1, PXN, SRC, PTK2, NCK1, 674 11 15360 10.358780685190181 0.9929189310432516 0.02157155583396475 1.786272180436732 GOTERM_BP_ALL GO:0050776~regulation of immune response 12 1.70% 0.0039987333704856725 LCK, TRAF6, BCL10, IKBKG, C1QA, FYN, SMAD3, IL4, CR2, MAP3K7, IL12A, IL27RA, 674 99 15360 2.762341516050715 0.9999999992797789 0.07318199611492127 7.378465384685484 GOTERM_BP_ALL GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway 43 6.09% 2.967583083301135E-18 KIT, FGFR1, LCP2, PRKCA, SRC, RGS2, CBLC, ABI1, PTPRG, IGF1R, GAB1, ERBB2, COL1A2, GRB7, PTPN11, EGFR, PLAT, NTRK1, PTPRT, ALK, PLCE1, EPHA3, ROS1, EPHB1, PTK2, PIK3R1, NCK1, CTGF, CSF1R, TIMP3, FOXO1, PICK1, PXN, SNF1LK2, RAF1, KDR, EPHB2, IRS1, SORBS1, CBL, NTRK2, ADRB2, FGFR4, 674 194 15360 5.051240478448407 1.5591681519664163E-14 4.585788682254165E-16 5.676941608217569E-15 GOTERM_BP_ALL GO:0044260~cellular macromolecule metabolic process 209 29.60% 8.743337361743739E-7 KIT, PPP5C, CAPN3, TUBA3C, GZMB, PTPN6, CRY1, STAT1, MMP14, UPF1, MAP2K7, CDK3, PPEF1, PPP1R3A, FYN, PRKCG, ATG7, PLAT, PRKD3, OTUD7B, ADRBK1, EBI3, MAP3K14, SRPK1, CASP5, USP2, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, CSNK1A1, MAP3K5, CTBP1, GSPT2, CSNK2A1, PTPN11, PPEF2, CARM1, PTPRT, PRKDC, CTSB, JUN, MBD2, PTPRZ1, PICK1, IL4, MMP3, MMP9, FGFR4, CDC25A, SPTA1, BCL10, GSK3A, MAPK1, REL, USP9X, CRKL, RNF2, ANAPC10, HSP90AA1, ELA2, EPHB1, ZBTB16, MOS, SCG5, RAF1, EP300, ACP1, EPB42, BMP1, SIAH2, CDC2, C1QA, LIPE, HK3, MDM4, MMP7, PRKAR2A, IGF1R, NSF, BMPR1A, PEX6, CASP8, FGR, PCSK1, CHRM3, CAPN1, PCGF2, FER, NTRK1, BLK, PTPRN, PRKG1, CTSG, HCK, CDK5, MDM2, MAP3K8, RAC1, CBL, DYRK1A, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, PARP1, PCSK2, NEK2, CTSS, CDKN3, MAP3K7, ALK, IKBKAP, NUAK1, CDK2, WNT2, PTK2, TTN, CEBPE, IL12A, UBE2I, PXN, PARK2, SNF1LK2, BRSK2, CAMK4, IGFBP3, GZMA, PRKACA, DUSP6, ADRB2, PTPRH, CASK, ERBB2, ATG12, FGF2, FRK, AXL, MAPK14, CASP2, EPHA3, CTSF, CCNT1, VCPIP1, REN, TUBA1A, HDAC1, STAT5A, SMAD3, MAPK8, GNA14, CRYAA, EPHB2, CD28, FGFR1, MARK1, CALR, CREBBP, ATOX1, PDE4DIP, EGFR, SMAD4, TAF1, ACHE, CASP3, PPARGC1A, MAP3K4, ROS1, HCLS1, PIK3R1, CASP1, ABL1, CHAF1A, LRP2, MME, LNPEP, CAMK2A, MYT1, NEDD4, SERPINA5, FES, LIMK1, PRKCA, PFTK1, TEC, CBLC, PYCARD, PSMB9, PAK1, STAMBPL1, PPP1CA, STX12, WIPF1, TIE1, TRAF6, PTPRS, TP53, NCK1, CSF1R, LCK, PLAU, COPS5, KDR, CR2, VCP, NTRK2, 674 3534 15360 1.3477553364602277 0.0045832163200545395 3.892933933680176E-5 0.0016725739726330957 GOTERM_BP_ALL GO:0007167~enzyme linked receptor protein signaling pathway 55 7.79% 2.7067063765459788E-20 KIT, FGFR1, SRC, COL1A2, GRB7, EGFR, MAP3K7, PLAT, SMAD4, ALK, PLCE1, ROS1, EPHB1, PIK3R1, PTK2, TIMP3, FOXH1, PXN, SNF1LK2, RAF1, SMAD1, SORBS1, ADRB2, LCP2, AKAP3, PRKCA, CBLC, RGS2, CITED2, ABI1, PTPRG, IGF1R, BMPR1A, GAB1, ERBB2, PTPN11, MAP3K7IP1, PTPRT, NTRK1, EPHA3, SMAD2, PTPRS, NCK1, CTGF, CSF1R, SMAD7, FOXO1, PICK1, SMAD3, KDR, EPHB2, IRS1, CBL, NTRK2, FGFR4, 674 285 15360 4.397938466343901 1.4221035302372572E-16 5.688414120949029E-18 5.1778884091591364E-17 GOTERM_BP_ALL GO:0007166~cell surface receptor linked signal transduction 135 19.12% 2.9889059817560346E-9 KIT, CXCL2, IKBKG, SRC, NFKBIA, BAI1, PTPN6, CAP1, TNFRSF14, PDC, TAX1BP3, COL1A2, FYN, WNT1, MAP3K7, PLAT, DEFB1, LAMA3, ALK, PLCE1, AXIN1, HTR1A, WNT2, PRKD3, SLC9A3R1, PTK2, ADRA2A, RGS19, GNAI3, ITGB3, TIMP3, ADRBK1, FOXH1, LRP1, PXN, SNF1LK2, NOTCH1, SMAD1, GNB2L1, HOMER1, ADRB2, NEDD9, AKAP3, VAV1, RGS2, ABI1, GRM1, PTPRG, ITGB2, GAB1, CSNK1A1, ERBB2, CSNK2A1, PTPN11, MAP3K7IP1, PNOC, MAPK14, GNA12, PTPRT, EPHA3, AGTR2, GPR37, CTGF, LIFR, ARRB1, CSNK2B, STAT5A, PICK1, SMAD3, TNFRSF1B, GNA14, EPHB2, FGFR4, CD28, FGFR1, BCL10, OPRD1, MAPK1, IL27RA, FZD1, GRB7, EGFR, HEYL, BAI2, SMAD4, NOTCH4, APC2, ROS1, ZBTB33, EPHB1, PIK3R1, CCR1, APP, GLI1, SCG5, RAF1, MDFI, SORBS1, MAGI1, ADCYAP1, CTNNB1, VIPR2, LCP2, PRKCA, CNTN1, CBLC, CITED2, CCR3, PYCARD, IGF1R, BMPR1A, STAT3, CHRM3, MIF, SFRP1, NTRK1, SMAD2, TRAF6, PTPRS, OPRL1, NCK1, DIXDC1, SIX3, CSF1R, SMAD7, LCK, FOXO1, TGFB1I1, ASCL1, KDR, PARD3, TRPV1, IRS1, CBL, NTRK2, 674 1868 15360 1.6469795843155695 1.570358890568002E-5 1.9387297145456728E-7 5.717731887955324E-6 GOTERM_BP_ALL GO:0007165~signal transduction 287 40.65% 3.804341236573558E-26 CXCL2, KIT, PPP5C, FGF8, GZMB, BAI1, NFKBIA, PTPN6, PLCD1, STAT1, CAP1, RALA, MAP2K7, HMGB1, COL1A2, FYN, PRKCG, PLAT, DEFB1, TICAM1, PLCE1, PRKD3, SLC9A3R1, ADRA2A, OTUD7B, DFFA, ARRB2, CA8, TIMP3, ADRBK1, FOXH1, IL4R, AHR, SRPK1, NTS, GNB2L1, NEDD9, MS4A3, DDIT3, VAV1, RGS2, ABI1, GRM1, PTPRG, MAP3K3, ITGB2, NRIP1, PRKCE, GAB1, MAP3K5, CSNK1A1, CSNK2A1, PTPN11, RASIP1, PTPRT, FCGR2B, GJA1, AGTR2, IRS4, GPR37, ARRB1, FGF1, PICK1, CAV1, TNFRSF1B, GADD45G, IL4, FGFR4, ASIP, BCL10, MAPK1, INPPL1, INADL, IL27RA, REL, EDA2R, IGFBP5, SH2D1A, GRB7, NR5A1, CRKL, ACCN2, HSP90AA1, EPHB1, CCR1, CD74, RB1, APP, GLI1, SCG5, TRH, RAF1, EP300, MDFI, SORBS1, MAGI1, ADCYAP1, VIPR2, SIAH2, LCP2, RASA2, SRF, PRKAR2A, IGF1R, BMPR1A, STAT3, CASP8, FGR, CHRM3, MIF, SFRP1, DFFB, FER, NTRK1, BLK, GRN, SMAD2, PRKG1, NCOA1, OPRL1, HCK, CARD9, TRAF1, PRKAB1, SMAD7, FOXO1, DAXX, ARF1, TGFB1I1, RAC1, AKAP13, TRPV1, AKAP5, MICAL1, CBL, RAP1A, IKBKG, CAV3, SRC, CABP2, PER1, FHL2, IGFALS, SNX17, TNFRSF14, TAX1BP3, PDC, WNT1, AKAP8, YWHAE, MAP3K7, LAMA3, DLG4, ALK, AXIN1, CCL8, HTR1A, WNT2, PPFIA1, PTK2, SNX19, ARHGDIB, IL12A, RGS19, GNAI3, ELMO1, ITGB3, LRP1, S100A1, CHN1, PXN, S100A10, TRAF3, SNF1LK2, NOTCH1, CAMK4, SMAD1, GZMA, TRAF3IP2, IGFBP3, DUSP6, HOMER1, ADRB2, AKAP3, NMI, FGF7, GRAP2, ERBB2, FRK, FGF2, DNM2, MAP3K7IP1, PNOC, AXL, MAPK14, AR, CASP2, GNA12, ARHGEF9, EPHA3, CTGF, LIFR, REN, CSNK2B, CRK, STAT5A, RAC3, SMAD3, KIFAP3, MPP3, GNA14, MAPK8, EPHB2, PLD1, CD28, FGFR1, OPRD1, MARK1, TG, CREBBP, ANKRD1, IAPP, FZD1, PPARG, RHOH, EGFR, NPM1, RND1, HEYL, BAI2, SMAD4, NOTCH4, PPARGC1A, CASP3, APC2, MAP3K4, HCLS1, ROS1, ZBTB33, PIK3R1, CASP1, DCX, ABL1, SH2D3C, CSPG4, TRAIP, HIF1A, FES, CTNNB1, PRKCA, BCL2L1, LIMK1, CNTN1, TEC, CBLC, CITED2, CCR3, PYCARD, SHC2, SLA, PAK1, ITPR1, TIE1, TRAF6, PTPRS, FGD1, PDE4D, TP53, SH3GL2, STARD13, NCK1, DIXDC1, SIX3, CSF1R, ROPN1B, LCK, YWHAZ, PLAU, PLCG1, MAPK8IP1, ASCL1, KDR, PARD3, VCP, IRS1, NCOA2, NTRK2, 674 3758 15360 1.740429516931634 1.9988008856957475E-22 1.5375391428428826E-23 7.277647314843774E-23 GOTERM_BP_ALL GO:0007160~cell-matrix adhesion 13 1.84% 4.88818964883148E-4 ACTN2, PPFIA1, CTGF, ACTN3, ITGB3, ITGB2, CDK5, MMP14, PXN, MYF5, PPFIA2, CD44, SORBS1, 674 89 15360 3.328776714566732 0.9233788976030112 0.012333374348176163 0.9309712950786198 GOTERM_BP_ALL GO:0007155~cell adhesion 57 8.07% 1.4838207202866376E-4 DSC1, BCL10, DSG3, INPPL1, BAI1, IGFALS, MMP14, MYF5, EGFR, RND1, LAMA3, NRXN2, ACHE, PPFIA1, CCR1, ABL1, ARHGDIB, TTN, IL12A, ITGB3, DAG1, APP, PXN, CD44, SORBS1, NEDD9, MAGI1, HSPG2, ACTN2, BMP1, CTNNB1, CNTN1, CASK, VAV1, CADM1, NLGN1, CCR3, ACTN3, ITGB2, MPZ, CLSTN3, PKP2, FER, LAMA1, PTPRS, APBA1, ZEB2, CTGF, CDK5, ROPN1B, STAT5A, DSG2, SELE, TGFB1I1, RAC1, F11R, PPFIA2, 674 774 15360 1.6782830722517426 0.5414368437694383 0.004322062064572196 0.2834711831839254 GOTERM_BP_ALL GO:0007154~cell communication 324 45.89% 2.106663353661325E-33 CXCL2, KIT, PPP5C, FGF8, GZMB, BAI1, NFKBIA, HAP1, PTPN6, PLCD1, STAT1, CAP1, RALA, SNX5, MAP2K7, HMGB1, COL1A2, FYN, PRKCG, PLAT, DEFB1, TICAM1, PLCE1, PRKD3, SLC9A3R1, ADRA2A, OTUD7B, DFFA, ARRB2, CA8, TIMP3, CACNA1B, ADRBK1, FOXH1, IL4R, AHR, SRPK1, NTS, GNB2L1, NEDD9, MS4A3, DDIT3, PHOX2A, VAV1, RGS2, ABI1, NLGN1, GRM1, PTPRG, MAP3K3, NRIP1, ITGB2, PRKCE, GAB1, MAP3K5, CSNK1A1, MPZ, CSNK2A1, PTPN11, PPFIBP2, RASIP1, PTPRT, FCGR2B, GJA1, AGTR2, DLG2, IRS4, GPR37, ARRB1, FGF1, PICK1, CAV1, ACCN1, TNFRSF1B, GADD45G, IL4, FGFR4, ASIP, BCL10, MAPK1, INPPL1, INADL, IL27RA, REL, EDA2R, IGFBP5, SH2D1A, GRB7, NR5A1, PMP22, CRKL, GJA3, SNCB, NRXN2, ACCN2, HSP90AA1, EPHB1, CCR1, CD74, RB1, APP, GLI1, SCG5, TRH, RAF1, EP300, MDFI, SORBS1, ADCYAP1, MAGI1, SIAH2, VIPR2, DLGAP2, LCP2, SLC6A1, C1QA, RASA2, PRKAR2A, SRF, IGF1R, BMPR1A, FGR, CASP8, STAT3, PCSK1, SALL1, CHRM3, EFNA2, TH, MIF, SFRP1, DFFB, FER, BLK, NTRK1, GRN, SMAD2, PRKG1, NCOA1, OPRL1, HCK, CARD9, TRAF1, PRKAB1, SMAD7, FOXO1, DAXX, ARF1, RAC1, TGFB1I1, AKAP13, TRPV1, AKAP5, MICAL1, CBL, RAP1A, IKBKG, CAV3, SRC, NOS1, CABP2, PER1, SLC8A1, FHL2, IGFALS, SNX17, TNFRSF14, TAX1BP3, PDC, PCSK2, WNT1, AKAP8, KCNK3, YWHAE, MAP3K7, LAMA3, DLG4, ALK, AXIN1, CCL8, HTR1A, WNT2, PPFIA1, PTK2, SNX19, ARHGDIB, IL12A, RGS19, GNAI3, ELMO1, ITGB3, LRP1, S100A1, CHN1, PARK2, PXN, S100A10, TRAF3, SNF1LK2, NOTCH1, CAMK4, SMAD1, GZMA, TRAF3IP2, IGFBP3, DUSP6, HOMER1, ADRB2, AKAP3, NMI, FGF7, PLP1, GRAP2, ERBB2, FRK, FGF2, DNM2, MAP3K7IP1, AXL, PNOC, MAPK14, AR, CASP2, GNA12, EPHA3, ARHGEF9, CTGF, LIFR, REN, CSNK2B, GJA8, CRK, SNAP25, GABARAPL2, STAT5A, RAC3, SMAD3, KIFAP3, MPP3, GNA14, MAPK8, EPHB2, PLD1, CD28, FGFR1, OPRD1, LIN7A, MARK1, TG, CREBBP, ANKRD1, IAPP, FZD1, PPARG, RHOH, EGFR, NPM1, RND1, HEYL, BAI2, SMAD4, NOTCH4, ACHE, PPARGC1A, CASP3, APC2, MAP3K4, HCLS1, ROS1, ZBTB33, PIK3R1, CASP1, DCX, ABL1, SH2D3C, CSPG4, TRAIP, MME, LNPEP, HIF1A, FES, CTNNB1, PRKCA, BCL2L1, LIMK1, CNTN1, TEC, CBLC, CITED2, CCR3, PYCARD, SHC2, SLA, PAK1, ITPR1, TIE1, TRAF6, PTPRS, STX1A, FGD1, PDE4D, TP53, SH3GL2, STARD13, PPFIA4, NCK1, KIF5A, DIXDC1, APBA1, SIX3, CSF1R, ROPN1B, LCK, YWHAZ, PLAU, PLCG1, MAPK8IP1, ASCL1, KDR, PARD3, VCP, IRS1, NCOA2, NTRK2, 674 4123 15360 1.7908656008740143 1.1068409260136602E-29 1.8447348766894336E-30 4.030015171000206E-30 GOTERM_BP_ALL GO:0044238~primary metabolic process 431 61.05% 6.450034913449088E-8 KIT, PPP5C, SLC2A2, CAPN3, PTPN6, CRY1, MMP14, CDK3, HMGB1, NRF1, FYN, PPP1R3A, RAG1, PRKCG, ATG7, PLCE1, PRKD3, CHKA, RFXANK, DFFA, RCC1, AHR, ID2, MAP3K14, SUB1, GCM1, CLTCL1, GTF2H1, MAX, DDIT3, ABI1, ITGB2, NRIP1, PRKCE, CSNK1A1, MAP3K5, CTBP1, PPEF2, CARM1, PTPRT, PRKDC, HOXB9, RELB, ATF7IP2, E2F2, CTSB, JUN, PTPRZ1, HOXB7, PICK1, PAX3, CAV1, ATP2B2, MMP3, MMP9, FGFR4, CDC25A, BCL10, HNF4A, IL27RA, REL, EDA2R, SMARCA4, U2AF2, NR5A1, SNCB, CBX2, RNF2, ANAPC10, HSP90AA1, ELA2, FOSL1, TAF13, RB1, EP300, EPB42, DLGAP2, LIPE, DLX5, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, CAPN1, TH, INSIG2, MIF, PTPRN, GRN, PRKG1, IRF8, SETDB1, IRF2, HOXD10, ZEB2, GATA2, FOXO1, DAXX, MAP3K8, TGFB1I1, XAB2, CBL, IKBKG, CAV3, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, NEK2, RYBP, CTSS, CDKN3, MAP3K7, CIITA, ALK, NUAK1, CPNE1, CEBPE, DAG1, UBE2I, FOS, NOTCH1, SMAD1, IGFBP3, DUSP6, EYA1, PTPRH, ASCC2, PLP1, IFI16, SAFB, ORC2L, ERCC4, FGF2, AXL, AR, CASP2, ERCC2, EPHA3, CTSF, VCPIP1, CDC6, TUBA1A, HDAC1, DACH1, SMAD3, KIFAP3, MAPK8, GNA14, EPHB2, LIN7A, LHX3, CALR, NEUROD1, FZD1, RHOH, EGFR, ACHE, CASP3, PPARGC1A, ROS1, PIK3R1, MYOG, SI, TBP, HIF1A, CAMK2A, NEDD4, LIMK1, CBLC, CITED2, RBL1, PSMB9, PAK1, E2F1, NCOR1, MIZF, RAG2, TIE1, TRAF6, CDC45L, PLA2G2A, APBA1, HAND1, SIX3, DDC, LCK, PLAU, ZNF423, PLCG1, RAD52, PARD3, NCOA2, MAFK, TUBA3C, GATA4, GZMB, POU2AF1, PLCD1, STAT1, UPF1, MAP2K7, PPEF1, PRM1, PLAT, POU1F1, ZBTB17, SLC9A3R1, OTUD7B, ADRBK1, FOXH1, EBI3, SRY, SRPK1, CASP5, USP2, PHOX2A, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, DNMT3A, PTPN11, PPFIBP2, GLS2, EXOSC4, GJA1, RFXAP, ZNF208, MBD2, CUBN, GTF2F2, TNFRSF1B, WRN, GADD45G, IL4, SLC9A3R2, SREBF2, TCF4, SPTA1, KPNA2, GSK3A, ABCB4, MAPK1, DDX5, HOXC8, USP9X, CRKL, RXRG, MPP6, DBP, TCEA2, EPHB1, ZBTB16, CD74, APP, GLI1, MOS, SCG5, PTGS2, RAF1, MDFI, MAGI1, ACP1, ACTN2, BMP1, SIAH2, CDC2, C1QA, HK3, TLX1, MMP7, SRF, PRKAR2A, NSF, ACTN3, MYF6, PEX6, CASP8, FGR, PCSK1, SALL1, CHRM3, PCGF2, PLA2G7, HOXB2, PAX5, PABPC1, DFFB, CBX1, FER, NTRK1, BLK, POLR2A, SMAD2, NCOA1, CTSG, HCK, TRAF1, PRKAB1, CDK5, SMAD7, HAND2, MDM2, FANCA, SIX1, POU3F2, RAC1, SOX10, PAX2, WT1, DYRK1A, PER1, MEOX1, FHL2, MEOX2, YBX1, PARP1, PCSK2, DLG4, IKBKAP, AXIN1, CDK2, WNT2, PTK2, PPARA, KLF1, TTN, IL12A, LRP1, PXN, PARK2, SP4, CHAF1B, HOXD4, SNF1LK2, BRSK2, CAMK4, GZMA, PRKACA, HCFC1, CREB3, ADRB2, RFX1, CASK, NMI, TJP1, ERBB2, ATG12, TP73, FRK, DNM2, MAPK14, TTR, EXOSC1, CCNT1, REN, CTGF, CRK, STAT5A, FABP4, CRYAA, PLD1, CD28, RUNX1T1, FGFR1, TAL1, TG, MARK1, ETS1, CREBBP, ANKRD1, ATOX1, PDE4DIP, MYF5, PPARG, TRIP4, NPM1, HEYL, PAWR, SMAD4, NOTCH4, TAF1, APC2, MAP3K4, HCLS1, ZBTB33, CASP1, CHD1, ABL1, CHAF1A, HOXA9, LRP2, EAF2, MME, LNPEP, NHLH1, MYT1, FES, SERPINA5, CTNNB1, HOXA5, PRKCA, PFTK1, TEC, PYCARD, PARD6B, STAMBPL1, PPP1CA, NFE2, STX12, WIPF1, MYC, PTPRS, PDE4D, MEIS1, TP53, ZMYND11, NCK1, CSF1R, HIC1, COPS5, ASCL1, KDR, CR2, VCP, NTRK2, 674 8291 15360 1.184681684440638 3.3882743049973296E-4 3.355289870832223E-6 1.2338812144241373E-4 GOTERM_BP_ALL GO:0044237~cellular metabolic process 413 58.50% 4.62515847578598E-5 KIT, PPP5C, CAPN3, PTPN6, CRY1, MMP14, CDK3, HMGB1, NRF1, FYN, PPP1R3A, PRKCG, RAG1, ATG7, PLCE1, PRKD3, RFXANK, DFFA, RCC1, CA8, SLC34A1, AHR, ID2, MAP3K14, SUB1, GCM1, GTF2H1, MAX, DDIT3, ABI1, ITGB2, NRIP1, PRKCE, CSNK1A1, MAP3K5, CTBP1, PPEF2, CARM1, PTPRT, PRKDC, HOXB9, RELB, ATF7IP2, E2F2, CTSB, JUN, PTPRZ1, HOXB7, PICK1, PAX3, CAV1, ATP2B2, MMP3, MMP9, FGFR4, CDC25A, BCL10, INPPL1, HNF4A, IL27RA, REL, EDA2R, SMARCA4, U2AF2, NR5A1, SNCB, CBX2, RNF2, ANAPC10, HSP90AA1, ELA2, FOSL1, TAF13, RB1, NCF2, EP300, EPB42, DLGAP2, LIPE, DLX5, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, CAPN1, TH, INSIG2, MIF, PTPRN, GRN, PRKG1, IRF8, SETDB1, IRF2, HOXD10, ZEB2, GATA2, FOXO1, DAXX, MAP3K8, TGFB1I1, XAB2, MICAL1, CBL, IKBKG, CAV3, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, NEK2, RYBP, CTSS, CDKN3, MAP3K7, CIITA, ALK, NUAK1, CEBPE, UBE2I, FOS, NOTCH1, SMAD1, IGFBP3, DUSP6, EYA1, PTPRH, ASCC2, PLP1, IFI16, SAFB, ORC2L, ERCC4, FGF2, AXL, AR, CASP2, ERCC2, EPHA3, CTSF, VCPIP1, CDC6, TUBA1A, HDAC1, DACH1, SMAD3, MAPK8, GNA14, EPHB2, LHX3, CALR, NEUROD1, FZD1, RHOH, EGFR, ACHE, CASP3, PPARGC1A, ROS1, PIK3R1, MYOG, TBP, HIF1A, CAMK2A, NEDD4, LIMK1, CBLC, CITED2, RBL1, PSMB9, PAK1, E2F1, NCOR1, MIZF, RAG2, TIE1, TRAF6, CDC45L, PLA2G2A, HAND1, SIX3, DDC, LCK, PLAU, ZNF423, RAD52, NCOA2, MAFK, TUBA3C, GATA4, GZMB, POU2AF1, PLCD1, STAT1, UPF1, MAP2K7, PPEF1, PRM1, PLAT, POU1F1, ZBTB17, OTUD7B, ADRBK1, FOXH1, EBI3, SRY, SRPK1, CASP5, USP2, PHOX2A, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, DNMT3A, PTPN11, PPFIBP2, GLS2, EXOSC4, RFXAP, ZNF208, MBD2, CUBN, GTF2F2, TNFRSF1B, WRN, GADD45G, IL4, SREBF2, ABP1, TCF4, SPTA1, KPNA2, GPHN, GSK3A, MAPK1, DDX5, HOXC8, USP9X, CRKL, RXRG, DBP, TCEA2, EPHB1, ZBTB16, CD74, APP, GLI1, MOS, SCG5, PTGS2, RAF1, MDFI, ACP1, BMP1, SIAH2, CDC2, C1QA, HK3, TLX1, MMP7, SRF, PRKAR2A, NSF, ACTN3, MYF6, PEX6, CASP8, FGR, PCSK1, SALL1, CHRM3, PCGF2, HOXB2, PAX5, PABPC1, DFFB, CBX1, FER, NTRK1, BLK, POLR2A, SMAD2, NCOA1, CTSG, HCK, PRKAB1, CDK5, SMAD7, HAND2, MDM2, FANCA, SIX1, POU3F2, RAC1, SOX10, PAX2, WT1, DYRK1A, NOS1, PER1, MEOX1, FHL2, MEOX2, YBX1, PARP1, PCSK2, IKBKAP, CDK2, WNT2, PTK2, PPARA, KLF1, TTN, IL12A, PXN, PARK2, SP4, CHAF1B, HOXD4, SNF1LK2, BRSK2, CAMK4, GZMA, PRKACA, HCFC1, CREB3, ADRB2, RFX1, CASK, NMI, ERBB2, ATG12, TP73, FRK, DNM2, MAPK14, TTR, EXOSC1, CCNT1, REN, CTGF, CRK, STAT5A, FABP4, CRYAA, PLD1, CD28, RUNX1T1, FGFR1, TAL1, TG, MARK1, ETS1, CREBBP, ANKRD1, ATOX1, PDE4DIP, MYF5, PPARG, TRIP4, NPM1, HEYL, PAWR, SMAD4, NOTCH4, TAF1, MAP3K4, HCLS1, ZBTB33, CASP1, ABL1, CHD1, CHAF1A, HOXA9, EAF2, LRP2, MME, LNPEP, NHLH1, MYT1, FES, SERPINA5, CTNNB1, HOXA5, PRKCA, PFTK1, TEC, PYCARD, STAMBPL1, PPP1CA, NFE2, STX12, WIPF1, MYC, PTPRS, PDE4D, MEIS1, TP53, ZMYND11, NCK1, CSF1R, HIC1, COPS5, ASCL1, KDR, CR2, VCP, NTRK2, 674 8269 15360 1.138225677901052 0.21573746310065745 0.0014806798212798622 0.08844149657115663 GOTERM_BP_ALL GO:0050727~regulation of inflammatory response 7 0.99% 0.0013851622883219704 STAT5A, PRKCA, FABP4, ELA2, TNFRSF1B, PTGS2, ADRB2, 674 29 15360 5.500869743169957 0.9993126642597497 0.02952526350985174 2.616784365123792 GOTERM_BP_ALL GO:0043687~post-translational protein modification 142 20.11% 1.0654914043740609E-18 KIT, PPP5C, DYRK1A, SRC, PTPN6, UBE2O, CDC14A, CRY1, STAT1, PARP1, TNFRSF14, MMP14, MAP2K7, CDK3, PPEF1, FYN, PCSK2, NEK2, CDKN3, PRKCG, MAP3K7, ATG7, ALK, IKBKAP, CDK2, NUAK1, WNT2, PRKD3, PTK2, OTUD7B, TTN, IL12A, ADRBK1, UBE2I, PARK2, MAP3K14, SRPK1, SNF1LK2, BRSK2, CAMK4, IGFBP3, PRKACA, USP2, DUSP6, PTPRH, CASK, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, MAP3K5, CSNK1A1, CTBP1, ERBB2, CSNK2A1, ATG12, FRK, FGF2, PTPN11, PPEF2, AXL, MAPK14, PTPRT, CARM1, EPHA3, CCNT1, VCPIP1, JUN, PTPRZ1, HDAC1, PICK1, IL4, GNA14, MAPK8, EPHB2, FGFR4, CDC25A, FGFR1, BCL10, GSK3A, MAPK1, MARK1, CREBBP, EGFR, USP9X, CRKL, RNF2, TAF1, ANAPC10, PPARGC1A, MAP3K4, HCLS1, ROS1, EPHB1, PIK3R1, ZBTB16, ABL1, MOS, SCG5, CAMK2A, RAF1, EP300, NEDD4, ACP1, FES, EPB42, SIAH2, PRKCA, LIMK1, PFTK1, CDC2, TEC, LIPE, CBLC, PRKAR2A, IGF1R, BMPR1A, PAK1, FGR, PCGF2, STAMBPL1, PPP1CA, FER, BLK, NTRK1, PTPRN, PRKG1, TIE1, TRAF6, PTPRS, HCK, TP53, CSF1R, CDK5, LCK, MDM2, MAP3K8, KDR, VCP, CBL, NTRK2, 674 1522 15360 2.126204392939167 5.5980918385813156E-15 1.8058360769617147E-16 2.0382689605982915E-15 GOTERM_BP_ALL GO:0021700~developmental maturation 16 2.27% 4.917708666134485E-7 EPB42, CTNNB1, FGFR1, ACTC1, NLGN1, PLP1, KLF1, TTN, REN, ACTB, GATA2, APP, PICK1, PTGS2, RND1, SOX10, 674 73 15360 4.99491890573554 0.0025804297210983984 2.3276889164147718E-5 9.407460450527871E-4 GOTERM_BP_ALL GO:0060047~heart contraction 13 1.84% 1.4957445165396502E-6 PRKCA, ACTC1, TNNT2, SLC8A1, CSRP3, CACNA1B, ADRBK1, SCN5A, S100A1, SP4, PLN, KCNJ12, ADRB2, 674 51 15360 5.809041717577239 0.007827849127405972 6.337418183111065E-5 0.002861297868583801 GOTERM_BP_ALL GO:0040007~growth 24 3.40% 0.004679095371497943 FGFR1, SETDB1, HOXA5, TP53, CTGF, NOV, RB1, IGFBP5, APP, STAT5A, PLG, SMARCA4, DDX5, TP73, POU3F2, SMAD3, WRN, PTGS2, IGFBP3, AR, SMAD4, ADRB2, PLCE1, NEDD9, 674 291 15360 1.8795313408180123 0.9999999999801271 0.08173133532346144 8.581329592330455 GOTERM_BP_ALL GO:0043623~cellular protein complex assembly 9 1.27% 0.00445161719947601 PICK1, PXN, SMAD3, SRC, PTK2, NCK1, MBD2, SMAD4, ADRB2, 674 60 15360 3.4183976261127595 0.9999999999339765 0.07869264176798962 8.180810665375226 GOTERM_BP_ALL GO:0050679~positive regulation of epithelial cell proliferation 6 0.85% 0.001802855306874147 LAMA1, ERBB2, FGF2, EGFR, BMPR1A, GRN, 674 21 15360 6.511233573548115 0.9999236933573094 0.03692310991351522 3.393047551073869 GOTERM_BP_ALL GO:0050678~regulation of epithelial cell proliferation 8 1.13% 8.256926500912214E-4 LAMA1, ERBB2, SMAD3, FGF2, EGFR, NOTCH1, BMPR1A, GRN, 674 36 15360 5.064292779426311 0.9869632263885466 0.01927364079281657 1.5677705322662217 GOTERM_BP_ALL GO:0050673~epithelial cell proliferation 9 1.27% 2.884279485061112E-4 KIT, LAMA1, ERBB2, SMAD3, FGF2, EGFR, NOTCH1, BMPR1A, GRN, 674 40 15360 5.12759643916914 0.7803278398967188 0.007782031182527627 0.5503180665211604 GOTERM_BP_ALL GO:0007089~traversing start control point of mitotic cell cycle 4 0.57% 0.0025673669357314487 CDK2, MDM2, CDC2, CDC6, 674 7 15360 13.022467147096227 0.9999986376386966 0.04932722418815705 4.798691138424537 GOTERM_BP_ALL GO:0050670~regulation of lymphocyte proliferation 8 1.13% 0.004103318906301223 CD28, EBI3, STAT5A, ERBB2, CASP3, IL4, NCK1, IL12A, 674 47 15360 3.8790327672201528 0.9999999995851857 0.07425295487150196 7.564340781526857 GOTERM_BP_ALL GO:0000278~mitotic cell cycle 28 3.97% 8.061665423073763E-4 CDC25A, CD28, PPP5C, KPNA2, CDC2, E2F1, GSPT2, CDK3, AKAP8, DNM2, NEK2, CDKN3, PRM1, RNF2, TAF1, CDK2, ANAPC10, TP53, FOSL1, ABL1, CDC6, RCC1, TTN, RB1, UBE2I, STAT5A, MDM2, NEDD9, 674 318 15360 2.0066065729802363 0.9855535595516244 0.018905966731901702 1.5309660915011403 GOTERM_BP_ALL GO:0035295~tube development 24 3.40% 1.0391946343397794E-7 NOTCH4, CTNNB1, FGFR1, BCL10, WNT2, AGTR2, KCNJ8, ZEB2, FGF1, BMPR1A, CASP8, FOXH1, GLI1, MMP14, CAV1, FGF2, MAP3K7IP1, NOTCH1, NTS, EP300, MAP3K7, CD44, SMAD4, ADRB2, 674 147 15360 3.7207048991703506 5.458438624937889E-4 5.300887789938535E-6 1.9879617649820602E-4 GOTERM_BP_ALL GO:0043549~regulation of kinase activity 40 5.67% 6.462789392625828E-13 CDC25A, KIT, GTF2H1, CDK5R2, PRKCA, IKBKG, CAV3, GRM1, RBL1, GAB1, MAP3K5, ERBB2, PTPN11, FGF2, MAP3K7IP1, EGFR, CDKN3, MAP3K7, PLCE1, TRAF6, CCNT1, CASP3, MAP3K4, PRKD3, ELA2, ADRA2A, CDC6, RB1, DAXX, PICK1, FABP4, CAV1, GADD45G, C13orf15, GNB2L1, PARD3, MDFI, DUSP6, IRS1, ADRB2, 674 236 15360 3.862596187698034 3.3954543621206312E-9 6.063316515536599E-11 1.236288849071343E-9 GOTERM_BP_ALL GO:0009268~response to pH 4 0.57% 0.005768964486061542 GJA1, ACCN2, KCNJ8, TRPV1, 674 9 15360 10.128585558852622 0.9999999999999372 0.09545490824924419 10.477391038905637 GOTERM_BP_ALL GO:0055082~cellular chemical homeostasis 21 2.97% 0.0011842967832914467 CP, OPRL1, PRKCA, BCL2L1, CAV3, ELA2, SLC9A3R1, CCR1, CCR3, CALR, KCNA5, IREB2, CSRP3, LCK, ATOX1, APP, ATP2B2, PLN, ATP7B, MYC, PLCE1, 674 214 15360 2.2363348955877864 0.9980226203764038 0.02592791548751039 2.2413836816623123 GOTERM_BP_ALL GO:0007049~cell cycle 96 13.60% 3.6398150492784637E-16 CD28, CDC25A, PPP5C, KPNA2, BCL10, CDK5R2, RAP1A, MAPK1, FGF8, CALR, CDC14A, STAT1, BIN1, UPF1, CDK3, AKAP8, NEK2, EGFR, NPM1, PRM1, CDKN3, RNF2, TAF1, AXIN1, SEPT4, CDK2, ANAPC10, CASP3, APC2, ZBTB17, FOSL1, ABL1, TTN, RCC1, CHAF1A, ACPP, RB1, UBE2I, AHR, CHAF1B, MOS, SRPK1, C13orf15, HCFC1, EP300, SEPT8, DUSP6, ADCYAP1, NEDD9, SIAH2, GTF2H1, PRKCA, DDIT3, CDC2, CADM1, RGS2, CITED2, PYCARD, MDM4, FGF7, IGF1R, RBL1, PARD6B, E2F1, GSPT2, TP73, PPP1CA, FRK, PTPN11, FGF2, DNM2, AXL, ERCC2, MYC, CDC45L, CCNT1, TP53, ZMYND11, E2F2, STARD13, CDC6, FGF1, CDK5, LCK, DAXX, STAT5A, MDM2, HIC1, RAD52, GADD45G, COPS5, CRYAA, WT1, EPHB2, PARD3, PLEKHO1, 674 894 15360 2.4471750343536534 1.7499335314141717E-12 4.729550084903167E-14 6.328271240363392E-13 GOTERM_BP_ALL GO:0035282~segmentation 8 1.13% 8.256926500912214E-4 MEOX2, MYF5, SFRP1, ZEB2, EP300, MEOX1, MYF6, PRKDC, 674 36 15360 5.064292779426311 0.9869632263885466 0.01927364079281657 1.5677705322662217 GOTERM_BP_ALL GO:0055070~copper ion homeostasis 4 0.57% 0.005768964486061542 ATOX1, APP, CP, ATP7B, 674 9 15360 10.128585558852622 0.9999999999999372 0.09545490824924419 10.477391038905637 GOTERM_BP_ALL GO:0000187~activation of MAPK activity 10 1.42% 0.0011258418693196374 GAB1, DAXX, MAP3K5, PTPN11, FGF2, GRM1, ADRA2A, MDFI, ADRB2, PLCE1, 674 60 15360 3.798219584569733 0.9973107836769476 0.024975576315805936 2.131879004989934 GOTERM_BP_ALL GO:0031589~cell-substrate adhesion 13 1.84% 7.31693303248911E-4 ACTN2, PPFIA1, CTGF, ACTN3, ITGB3, ITGB2, CDK5, MMP14, PXN, MYF5, PPFIA2, CD44, SORBS1, 674 93 15360 3.1856035225423565 0.978629070863652 0.01732866376632547 1.3904729358561463 GOTERM_BP_ALL GO:0035270~endocrine system development 8 1.13% 5.741436134507065E-4 GLI1, HOXA5, SIX1, POU1F1, POU3F2, NR5A1, CRKL, GATA2, 674 34 15360 5.362192354686682 0.9510725574850066 0.014198786527557461 1.0926304322466773 GOTERM_BP_ALL GO:0055066~di-, tri-valent inorganic cation homeostasis 17 2.41% 0.001898386351700455 CP, OPRL1, PRKCA, ELA2, CCR3, CCR1, CALR, IREB2, CSRP3, LCK, ATOX1, APP, ATP2B2, PLN, ATP7B, MYC, PLCE1, 674 161 15360 2.4063254510938683 0.999953849430605 0.038247792847482254 3.569761730799037 GOTERM_BP_ALL GO:0000165~MAPKKK cascade 31 4.39% 1.93394314594908E-11 FGFR1, PRKCA, MAPK1, CAV3, GRM1, MAP3K3, PAK1, EDA2R, GAB1, MAP3K5, MAP2K7, FGF2, PTPN11, MAP3K7IP1, MAP3K7, CRKL, PLCE1, MAP3K4, CARD9, ADRA2A, REN, SH2D3C, DAXX, CAV1, GADD45G, MAPK8IP1, SMAD1, MAPK8, DUSP6, MDFI, ADRB2, 674 163 15360 4.334164679324971 1.0160930208336083E-7 1.665726334643125E-9 3.699601736073532E-8 GOTERM_BP_ALL GO:0035239~tube morphogenesis 17 2.41% 1.8309673305097837E-5 NOTCH4, CTNNB1, BCL10, FGFR1, AGTR2, WNT2, KCNJ8, ZEB2, CASP8, MMP14, CAV1, NOTCH1, NTS, MAP3K7, CD44, SMAD4, ADRB2, 674 108 15360 3.5872073854269697 0.0917175715910864 6.164759534006414E-4 0.03502031555325802 GOTERM_BP_ALL GO:0000122~negative regulation of transcription from RNA polymerase II promoter 27 3.82% 1.6562563945251762E-9 CTNNB1, MDM4, RBL1, TWIST1, NRIP1, STAT3, ORC2L, E2F1, SMARCA4, HMGB1, PPARG, RYBP, PAWR, RNF2, CBX2, IRF8, IRF2, ZMYND11, MBD2, HAND1, RB1, ID2, MDM2, SMAD3, MDFI, NCOA2, TCF4, 674 150 15360 4.102077151335312 8.701933030597075E-6 1.1015152423521357E-7 3.168393336583364E-6 GOTERM_BP_ALL GO:0007010~cytoskeleton organization and biogenesis 55 7.79% 4.892284478066456E-9 SPTA1, KPNA2, TUBA3C, HAP1, KRT8, MARK1, CALR, CAP1, FHOD1, PDE4DIP, KIFC3, RND1, PLCE1, WNT2, EPB41L3, DOCK2, ADRA2A, ABL1, RCC1, ARHGDIB, TTN, VIM, ELMO1, RAF1, LASP1, SORBS1, NEDD9, GFAP, LIMK1, NLGN1, KISS1, PAK1, MYH4, WIPF1, SYNPO, ABLIM3, PRKG1, FGD1, ACTC1, TNNT2, NCK1, KIF5A, APBA1, TUBA1A, ACTB, CRK, DYNLL1, SHANK1, SGCG, RAC3, RAC1, KIFAP3, CRYAA, MICAL1, CBL, 674 526 15360 2.3829134275817716 2.570373230292855E-5 2.9544895230326773E-7 9.35886586006518E-6 GOTERM_BP_ALL GO:0048878~chemical homeostasis 27 3.82% 1.935804331203142E-4 BCL2L1, PRKCA, CAV3, CCR3, CALR, KCNA5, SLC9A1, CSRP3, ATOX1, ATP7B, MYC, PLCE1, CP, OPRL1, PPARGC1A, SLC9A3, ELA2, SLC9A3R1, CCR1, IREB2, LCK, APP, ATP2B2, CAV1, FABP4, HIF1A, PLN, 674 275 15360 2.2374966280010793 0.6383831492051797 0.005512846285859019 0.3696673335958689 GOTERM_BP_ALL GO:0048869~cellular developmental process 196 27.76% 1.790166091084586E-34 GZMB, BAI1, NFKBIA, PTPN6, STAT1, MMP14, HMGB1, FYN, PRM1, RAG1, PRKCG, S100A7, DFFA, TIMP3, SRY, AHR, ID2, SRPK1, CASP5, GCM1, DDIT3, SERPINB2, NLGN1, ITGB2, PRKCE, MAP3K5, PTPN11, PRKDC, GJA1, AGTR2, RELB, E2F2, CTSB, JUN, FGF1, PTPRZ1, PICK1, PAX3, ATP2B2, TNFRSF1B, WRN, GADD45G, IL4, MMP9, BCL10, MAPK1, EDA2R, SMARCA4, HOXC8, NR5A1, ZBTB16, CD74, RB1, APP, GLI1, PTGS2, RAF1, EP300, MDFI, LMO2, ACTN2, EPB42, BMP1, SIAH2, CDC2, CADM1, TLX1, DLX5, MDM4, IGF1R, BMPR1A, ACTN3, TWIST1, MYF6, CASP8, SALL1, PAX5, MIF, SFRP1, DFFB, NTRK1, SMAD2, PRKG1, IRF8, CARD9, ACTC1, TRAF1, ZEB2, GATA2, CDK5, HAND2, DAXX, FOXO1, SIX1, POU3F2, TGFB1I1, SOX10, PAX2, F11R, IKBKG, BIN1, PLG, TNFRSF14, WNT1, RYBP, MAP3K7, LAMA3, AXIN1, WNT2, KLF1, TTN, CEBPE, IL12A, ELMO1, TRAF3, NOTCH1, BRSK2, IGFBP3, GZMA, ADRB2, PLP1, IFI16, CSRP3, ERBB2, ATG12, TP73, FGF2, DNM2, CASP2, GNA12, ERCC2, ATG5, REN, CTGF, HDAC1, ACTB, STAT5A, SMAD3, MAPK8, CRYAA, S100A4, CD28, FGFR1, NAIP, ATXN2, TAL1, CALR, ETS1, NEUROD1, IAPP, MYF5, FZD1, RHOH, PPARG, RND1, NPM1, PAWR, NOTCH4, SEPT4, PPP3R1, ACHE, CASP3, PPARGC1A, HCLS1, PIK3R1, DCX, CASP1, ABL1, CSPG4, TRAIP, EAF2, MYOG, TBP, NHLH1, MYT1, CTNNB1, LIMK1, BCL2L1, PRKCA, ANXA13, PYCARD, PARD6B, PAK1, E2F1, RAG2, TRAF6, TP53, HAND1, LCK, YWHAZ, ZNF423, ASCL1, KDR, PARD3, VCP, NTRK2, 674 1835 15360 2.434172333217442 9.405532642558415E-31 2.3513831606396038E-31 3.424560688893452E-31 GOTERM_BP_ALL GO:0006996~organelle organization and biogenesis 97 13.74% 3.5147558583176397E-9 PEX26, TUBA3C, HAP1, LMNA, SYP, CAP1, FHOD1, HMGB1, AKAP8, NEK2, PRM1, PLCE1, WNT2, DOCK2, ADRA2A, DFFA, RCC1, ARHGDIB, KLF1, TTN, ELMO1, CHAF1B, NEDD9, GFAP, NLGN1, SAFB, HIST3H3, ERCC4, ATG12, EXOSC4, SYNPO, ABLIM3, CARM1, EXOSC1, ATG5, TNNT2, TUBA1A, HDAC1, ACTB, CRK, DYNLL1, SGCG, RAC3, KIFAP3, WRN, CRYAA, SPTA1, KPNA2, KRT8, MARK1, CALR, CREBBP, SMARCA4, PDE4DIP, KIFC3, RND1, NPM1, RNF2, CBX2, CASP3, PPARGC1A, EPB41L3, HSP90AA1, ABL1, CHD1, VIM, CHAF1A, RB1, RAF1, EP300, LASP1, SORBS1, LIMK1, BCL2L1, KISS1, RBL1, PAK1, PEX6, PCGF2, NCOR1, MYH4, DFFB, CBX1, WIPF1, PRKG1, SETDB1, FGD1, TP53, ACTC1, PEX19, NCK1, APBA1, KIF5A, SHANK1, RAC1, MICAL1, CBL, 674 1195 15360 1.849844182610531 1.846635660396334E-5 2.2520152476168676E-7 6.723674572661764E-6 GOTERM_BP_ALL GO:0003015~heart process 13 1.84% 1.4957445165396502E-6 PRKCA, ACTC1, TNNT2, SLC8A1, CSRP3, CACNA1B, ADRBK1, SCN5A, S100A1, SP4, PLN, KCNJ12, ADRB2, 674 51 15360 5.809041717577239 0.007827849127405972 6.337418183111065E-5 0.002861297868583801 GOTERM_BP_ALL GO:0048856~anatomical structure development 205 29.04% 3.254689835784621E-29 KIT, CAPN3, MAFK, KCNJ8, FGF8, GATA4, BAI1, NFKBIA, CAP1, MMP14, COL1A2, FYN, RAG1, S100A7, PLCE1, POU1F1, ADRBK1, FOXH1, ID2, NTS, GCM1, CLTCL1, NEDD9, DDIT3, NLGN1, ITGB2, NRIP1, MPZ, PTPN11, PRKDC, GJA1, AGTR2, RELB, JUN, FGF1, PTPRZ1, PICK1, PAX3, CAV1, ATP2B2, ACCN1, IL4, MMP9, SPTA1, BCL10, MAPK1, DCN, IL27RA, EDA2R, IGFBP5, SMARCA4, DDX5, HOXC8, NR5A1, PMP22, CRKL, NRXN2, RNF2, EPHB1, ZBTB16, AKAP2, CD74, RB1, APP, GLI1, PTGS2, EP300, SNTG2, LMO2, ACTN2, EPB42, BMP1, TLX1, DLX5, SRF, IGF1R, BMPR1A, TWIST1, MYF6, STAT3, CASP8, SALL1, CHRM3, TH, ERC2, APBA2, PAX5, PKP2, SFRP1, NTRK1, GRN, SMAD2, PRKG1, SETDB1, IRF8, HCK, ACTC1, HOXD10, ZEB2, GATA2, CDK5, HAND2, FOXO1, SIX1, POU3F2, BDNF, RAC1, PLN, SOX10, PAX2, F11R, XAB2, DYRK1A, CAV3, PLG, WNT1, MAP3K7, LAMA3, ALK, DLG4, WNT2, PPARA, KLF1, TTN, CEBPE, DAG1, FOS, PARK2, NOTCH1, BRSK2, SMAD1, KRT17, IGFBP3, EYA1, ADRB2, FGF7, PLP1, NOV, IFI16, CSRP3, ERBB2, TP73, FGF2, MAP3K7IP1, AR, GNA12, ERCC2, CTGF, GJA8, ACTB, DYNLL1, STAT5A, SGCG, RAC3, SMAD3, EPHB2, FGFR1, NAIP, LHX3, TAL1, ETS1, NEUROD1, MYF5, FZD1, RHOH, PPARG, EGFR, RND1, HEYL, SMAD4, NOTCH4, PPP3R1, ACHE, CASP3, HCLS1, PIK3R1, DCX, CSPG4, LRP2, MYOG, NHLH1, MYT1, CD44, CTNNB1, HOXA5, LIMK1, CITED2, PARD6B, E2F1, RAG2, TIE1, FGD1, TP53, SH3GL2, ALPL, NCK1, APBA1, SIX3, HAND1, LCK, ZNF423, ASCL1, KDR, PARD3, NTRK2, 674 2153 15360 2.1699071477105303 1.71001403972124E-25 1.5545582179283998E-26 6.226172488507074E-26 GOTERM_BP_ALL GO:0003013~circulatory system process 23 3.26% 3.879934107823468E-6 WNT2, AGTR2, KCNJ8, PRKCA, ACTC1, TNNT2, REN, SLC8A1, CSRP3, MEOX2, CACNA1B, ADRBK1, SCN5A, S100A1, SP4, CAV1, HOXB2, NFE2, PTGS2, PLN, NTS, KCNJ12, ADRB2, 674 167 15360 3.138648518985767 0.02017883959062472 1.5560020867222413E-4 0.007421994290846001 GOTERM_BP_ALL GO:0003012~muscle system process 20 2.83% 1.3338780132905452E-4 ACTN2, PRKG1, GJA1, PRKCA, PDE4D, ACTC1, NOS1, TNNT2, TTN, ACTN3, SLC8A1, SCN5A, DAG1, CHRM3, MYH4, PLN, MYL3, KCNJ12, ADRB2, PLCE1, 674 167 15360 2.729259581726754 0.5038446783184953 0.003907798530832118 0.25486054627033017 GOTERM_BP_ALL GO:0000080~G1 phase of mitotic cell cycle 6 0.85% 0.001424407351920399 TAF1, E2F1, CDK2, MDM2, CDC2, CDC6, 674 20 15360 6.83679525222552 0.999440893905526 0.029865475081189197 2.6899703573385225 GOTERM_BP_ALL GO:0003008~system process 99 14.02% 1.1305409243280425E-5 RPGRIP1, TRPC3, KCNJ8, HAP1, NOS1, SLC8A1, CRY1, MEOX2, PDC, COL1A2, PPEF1, KCNK3, PLCE1, DLG4, AXIN1, WNT2, ARRB2, TTN, TIMP3, ADRBK1, CACNA1B, DAG1, S100A1, PARK2, SP4, CAMK4, NTS, EYA1, HOMER1, ADRB2, PHOX2A, NLGN1, GRM1, RPGR, PLP1, CSRP3, MPZ, ERBB2, PTPN11, PPEF2, PNOC, ERCC2, GJA1, AGTR2, DLG2, TNNT2, ARRB1, REN, GJA8, ACTB, GABARAPL2, SNAP25, PAX3, ATP2B2, CAV1, RAC3, ACCN1, CRYAA, RBP4, OPRD1, MAPK1, LIN7A, IAPP, KIFC3, MYL3, KCNJ12, PMP22, GJA3, SNCB, NRXN2, ACHE, APP, PTGS2, ACTN2, CTNNB1, SLC6A1, DLGAP2, PRKCA, ACTN3, SCN5A, CHRM3, TH, HOXB2, MYH4, NFE2, PRKG1, OPRL1, STX1A, PDE4D, ACTC1, KIF5A, APBA1, SIX3, SIX1, PLN, SOX10, PAX2, TRPV1, AKAP5, 674 1461 15360 1.5442453341782485 0.057669254285143245 3.959146446366191E-4 0.021624860838231896 GOTERM_BP_ALL GO:0003002~regionalization 21 2.97% 6.471783710373322E-8 SMAD2, RNF2, CTNNB1, ZEB2, MEOX1, FGF1, BMPR1A, MYF6, NEUROD1, MEOX2, FOXH1, GLI1, PCGF2, MYF5, FGF2, SFRP1, EP300, CRKL, MDFI, SMAD4, PRKDC, 674 111 15360 4.311492501403481 3.399697242626454E-4 3.3335976501458475E-6 1.2380417205859473E-4 GOTERM_BP_ALL GO:0000074~regulation of progression through cell cycle 66 9.35% 2.7458510652725327E-14 CD28, CDC25A, BCL10, CDK5R2, RAP1A, FGF8, CALR, CDC14A, STAT1, BIN1, CDK3, NEK2, EGFR, CDKN3, AXIN1, CDK2, ANAPC10, CASP3, APC2, ZBTB17, ABL1, RCC1, ACPP, RB1, SRPK1, MOS, C13orf15, HCFC1, DUSP6, NEDD9, ADCYAP1, GTF2H1, PRKCA, DDIT3, CDC2, CADM1, CITED2, PYCARD, MDM4, FGF7, IGF1R, RBL1, TP73, FRK, FGF2, PTPN11, AXL, ERCC2, MYC, CDC45L, CCNT1, TP53, ZMYND11, E2F2, STARD13, CDC6, FGF1, LCK, STAT5A, MDM2, HIC1, GADD45G, COPS5, EPHB2, WT1, PLEKHO1, 674 526 15360 2.8594961130981256 1.4407786075310014E-10 3.2744917888294367E-12 5.2458037913538647E-11 GOTERM_BP_ALL GO:0043412~biopolymer modification 149 21.10% 2.5166823170950263E-13 KIT, PPP5C, DYRK1A, SRC, PTPN6, UBE2O, CDC14A, CRY1, STAT1, PARP1, TNFRSF14, MMP14, MAP2K7, CDK3, PPEF1, FYN, PCSK2, NEK2, CDKN3, PRKCG, MAP3K7, ATG7, PLAT, ALK, IKBKAP, CDK2, NUAK1, WNT2, PRKD3, PTK2, OTUD7B, TTN, IL12A, ADRBK1, UBE2I, PARK2, FOS, MAP3K14, SRPK1, SNF1LK2, BRSK2, CAMK4, IGFBP3, PRKACA, USP2, DUSP6, PTPRH, CASK, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, MAP3K5, CSNK1A1, CTBP1, ERBB2, CSNK2A1, DNMT3A, ATG12, FRK, FGF2, PTPN11, PPEF2, AXL, MAPK14, PTPRT, CARM1, PRKDC, EPHA3, CCNT1, VCPIP1, JUN, PTPRZ1, HDAC1, PICK1, IL4, GNA14, MAPK8, EPHB2, FGFR4, CDC25A, FGFR1, BCL10, GSK3A, MAPK1, MARK1, CREBBP, EGFR, USP9X, CRKL, RNF2, TAF1, ANAPC10, PPARGC1A, MAP3K4, HCLS1, ROS1, EPHB1, PIK3R1, ZBTB16, ABL1, LRP2, MOS, SCG5, CAMK2A, RAF1, MYT1, EP300, NEDD4, ACP1, FES, EPB42, SIAH2, PRKCA, LIMK1, PFTK1, CDC2, TEC, LIPE, CBLC, PRKAR2A, IGF1R, BMPR1A, PAK1, FGR, CHRM3, PCGF2, STAMBPL1, PPP1CA, FER, BLK, NTRK1, PTPRN, PRKG1, TIE1, TRAF6, PTPRS, HCK, TP53, CSF1R, CDK5, LCK, MDM2, MAP3K8, KDR, VCP, CBL, NTRK2, 674 1877 15360 1.8090614323949605 1.3223664385719758E-9 2.592870362860822E-11 4.814704190891916E-10 GOTERM_BP_ALL GO:0043408~regulation of MAPKKK cascade 5 0.71% 0.004360369401066199 CARD9, CAV3, GRM1, REN, ADRB2, 674 16 15360 7.12166172106825 0.9999999998931369 0.07766171147838596 8.019684566612739 GOTERM_BP_ALL GO:0043406~positive regulation of MAP kinase activity 14 1.98% 6.61296217691882E-6 KIT, ELA2, ADRA2A, GRM1, GAB1, MAP3K5, DAXX, ERBB2, FGF2, PTPN11, EGFR, MDFI, PLCE1, ADRB2, 674 68 15360 4.691918310350847 0.034147954163816774 2.499300440106378E-4 0.012649738426984136 GOTERM_BP_ALL GO:0043405~regulation of MAP kinase activity 17 2.41% 5.1224999774252875E-6 KIT, PRKCA, ELA2, ADRA2A, GRM1, GAB1, MAP3K5, DAXX, ERBB2, CAV1, FGF2, PTPN11, EGFR, MDFI, DUSP6, ADRB2, PLCE1, 674 98 15360 3.9532489553684975 0.02655473801966146 2.0082821798528272E-4 0.00979881005686023 GOTERM_BP_ALL GO:0006952~defense response 40 5.67% 0.004882006464064119 CXCL2, BCL10, DNAJC3, PRKCA, C1QA, NMI, CADM1, CCR3, PYCARD, MEFV, IL27RA, ANKRD1, ITGB2, STAT3, SH2D1A, PLA2G7, MIF, DEFB1, S100A7, CIITA, CCL8, ELA2, CCR1, FOSL1, IL12A, CEBPE, CAMP, NCF2, STAT5A, FOS, FABP4, RAC1, SELE, TNFRSF1B, PTGS2, APOH, IL4, F11R, CR2, ADRB2, 674 577 15360 1.5798487006875839 0.9999999999931917 0.08429205516076 8.937195768882978 GOTERM_BP_ALL GO:0006950~response to stress 88 12.46% 1.962349676498859E-8 CXCL2, DNAJC3, MAPK1, PTPN6, HNF4A, CREBBP, CRY1, ATOX1, PLG, PARP1, MMP14, UPF1, MAP2K7, HMGB1, EGFR, NPM1, PRKCG, PLAT, S100A7, CCL8, ACHE, PPARGC1A, CASP3, MAP3K4, HSP90AA1, ELA2, CCR1, ADRA2A, PPARA, ABL1, TTN, CHAF1A, ITGB3, FOS, AHR, CHAF1B, HIF1A, PTGS2, EP300, ADRB2, GTF2H1, PRKCA, DDIT3, C1QA, CDC2, NMI, CITED2, CCR3, PYCARD, SERPIND1, FGF7, MEFV, IFI16, ITGB2, STAT3, GAB1, MAP3K5, ERCC4, PLA2G7, TP73, INSIG2, PTPN11, MIF, MAPK14, GNA12, ERCC2, PRKDC, RAG2, TP53, CTSB, CTGF, SMAD7, STAT5A, PLAU, FABP4, FANCA, RAC1, SELE, RAD52, GADD45G, TNFRSF1B, APOH, F11R, XAB2, MAPK8, CR2, TRPV1, VCP, 674 1081 15360 1.855189584322682 1.030965379466009E-4 1.0414323138308035E-6 3.753944609607984E-5 GOTERM_BP_ALL GO:0019725~cellular homeostasis 25 3.54% 0.005664440599896065 BCL2L1, DDIT3, PRKCA, CAV3, CCR3, SRF, CALR, KCNA5, CSRP3, ATOX1, PLG, ATP7B, PLCE1, MYC, CP, OPRL1, PPARGC1A, ELA2, SLC9A3R1, CCR1, IREB2, LCK, APP, ATP2B2, PLN, 674 313 15360 1.820233027749073 0.9999999999998908 0.09530096959920298 10.297177905974886 GOTERM_BP_ALL GO:0006936~muscle contraction 20 2.83% 1.3338780132905452E-4 ACTN2, PRKG1, GJA1, PRKCA, PDE4D, ACTC1, NOS1, TNNT2, TTN, ACTN3, SLC8A1, SCN5A, DAG1, CHRM3, MYH4, PLN, MYL3, KCNJ12, ADRB2, PLCE1, 674 167 15360 2.729259581726754 0.5038446783184953 0.003907798530832118 0.25486054627033017 GOTERM_BP_ALL GO:0006935~chemotaxis 21 2.97% 7.966086769224263E-6 CXCL2, CCL8, PRKCA, MAPK1, DOCK2, ELA2, CCR1, CCR3, FOSL1, SERPIND1, ITGB2, RALA, PLAU, FGF2, IL4, MAPK14, FER, PLD1, CREB3, DEFB1, IL16, 674 149 15360 3.2119172325891703 0.04099020136101139 2.8663005479567794E-4 0.015237903260423291 GOTERM_BP_ALL GO:0048771~tissue remodeling 13 1.84% 0.004861762160840456 BMP1, CTNNB1, ACHE, DLX5, ALPL, CTGF, CSPG4, IAPP, PLG, MMP14, GLI1, EGFR, ADRB2, 674 116 15360 2.5539752379003375 0.9999999999924237 0.0845106347897806 8.901750285231124 GOTERM_BP_ALL GO:0031347~regulation of defense response 7 0.99% 0.0013851622883219704 STAT5A, PRKCA, FABP4, ELA2, TNFRSF1B, PTGS2, ADRB2, 674 29 15360 5.500869743169957 0.9993126642597497 0.02952526350985174 2.616784365123792 GOTERM_BP_ALL GO:0006928~cell motility 47 6.66% 1.0543763241781173E-8 PRKCA, AKAP3, LIMK1, PARD6B, TWIST1, ITGB2, STAT3, GAB1, CAP1, PLG, MMP14, FYN, WNT1, EGFR, MAPK14, CRKL, IL16, LAMA3, MSN, PRKG1, TIE1, LAMA1, WNT2, DOCK2, ELA2, ADRA2A, NCK1, CTGF, ARHGDIB, ZEB2, VIM, ACTB, IL12A, CRK, ELMO1, ITGB3, CDK5, CSPG4, ROPN1B, PXN, SIX1, RAC1, PTGS2, ASCL1, KDR, F11R, MAPK8, 674 421 15360 2.544175588714168 5.5395397741464514E-5 5.956657593841896E-7 2.0170057790647178E-5 GOTERM_BP_ALL GO:0048747~muscle fiber development 8 1.13% 0.005821384579033544 APP, PLG, SIX1, ACTC1, NOTCH1, IGFBP3, TTN, ACTB, 674 50 15360 3.6462908011869435 0.9999999999999524 0.09568138482097865 10.56764103411062 GOTERM_BP_ALL GO:0006917~induction of apoptosis 21 2.97% 0.001118216165113106 PRKCA, MAPK1, IKBKG, CASP3, TP53, CADM1, PYCARD, ABL1, IL12A, IFI16, TIMP3, PRKCE, LCK, MAP3K5, DAXX, PLG, TRAIP, TP73, TRAF3, SMAD3, ERCC2, 674 213 15360 2.246834120449701 0.9972007255000553 0.02491356740796502 2.1175850627183634 GOTERM_BP_ALL GO:0048741~skeletal muscle fiber development 8 1.13% 0.005821384579033544 APP, PLG, SIX1, ACTC1, NOTCH1, IGFBP3, TTN, ACTB, 674 50 15360 3.6462908011869435 0.9999999999999524 0.09568138482097865 10.56764103411062 GOTERM_BP_ALL GO:0006915~apoptosis 96 13.60% 3.953305383611338E-20 CD28, BCL10, NAIP, MAPK1, IKBKG, GZMB, NFKBIA, PTPN6, CALR, IAPP, STAT1, PLG, TNFRSF14, HMGB1, RYBP, NPM1, PAWR, MAP3K7, AXIN1, SEPT4, CASP3, ZBTB16, PIK3R1, CASP1, ABL1, DFFA, IL12A, ELMO1, CD74, TIMP3, APP, EAF2, TRAIP, AHR, TRAF3, RAF1, GZMA, IGFBP3, CASP5, EP300, ADRB2, ACTN2, SIAH2, PRKCA, DDIT3, BCL2L1, CDC2, SERPINB2, CADM1, PYCARD, MDM4, IGF1R, ACTN3, IFI16, ITGB2, PAK1, CASP8, PRKCE, MAP3K5, E2F1, ATG12, TP73, MIF, DNM2, SFRP1, DFFB, CASP2, ERCC2, PRKDC, GJA1, TRAF6, AGTR2, CARD9, TP53, ACTC1, E2F2, CTSB, TRAF1, ATG5, HDAC1, CDK5, LCK, FOXO1, DAXX, YWHAZ, STAT5A, PAX3, SMAD3, GADD45G, WRN, TNFRSF1B, IL4, CRYAA, MAPK8, VCP, MMP9, 674 784 15360 2.790528674377763 2.077066648549397E-16 7.988717879036141E-18 7.562613477782909E-17 GOTERM_BP_ALL GO:0031325~positive regulation of cellular metabolic process 61 8.64% 2.907691430304543E-16 CD28, BCL10, GATA4, HNF4A, FHL2, CREBBP, REL, NEUROD1, PPARG, EGFR, PRKCG, NR5A1, SMAD4, NOTCH4, CDK2, PPARGC1A, POU1F1, HCLS1, ELA2, FOSL1, PPARA, IL12A, RB1, FOXH1, EBI3, APP, GLI1, MYOG, HIF1A, NOTCH1, SMAD1, EP300, ADRB2, CTNNB1, GTF2H1, PRKCA, DDIT3, TLX1, CITED2, SRF, MYF6, NRIP1, E2F1, TP73, FGF2, ERCC2, SMAD2, NCOA1, TP53, JUN, HAND1, HAND2, FOXO1, STAT5A, ZNF423, SMAD3, TGFB1I1, IL4, SOX10, NCOA2, TCF4, 674 416 15360 3.3417028075781783 1.7499335314141717E-12 4.8627768478581856E-14 6.328271240363392E-13 GOTERM_BP_ALL GO:0031324~negative regulation of cellular metabolic process 46 6.52% 2.174944657951285E-9 SERPINA5, CTNNB1, PRKCA, MDM4, PER1, RBL1, MYF6, TWIST1, NRIP1, STAT3, ORC2L, E2F1, SMARCA4, HMGB1, FZD1, NCOR1, PPARG, RYBP, PAWR, SMAD4, RNF2, CBX2, CDC45L, IRF8, IRF2, TP53, ELA2, ZMYND11, ZBTB16, JUN, CDC6, MBD2, ZEB2, HAND1, SIX3, RB1, DAXX, MDM2, ZNF423, ID2, FABP4, SMAD3, IGFBP3, MDFI, TCF4, NCOA2, 674 387 15360 2.708807765739654 1.1427094012583794E-5 1.4283948113202882E-7 4.160636213335067E-6 GOTERM_BP_ALL GO:0031323~regulation of cellular metabolic process 197 27.90% 1.3043172250113382E-11 MAFK, GATA4, POU2AF1, CRY1, STAT1, UPF1, HMGB1, NRF1, PRKCG, POU1F1, ZBTB17, RFXANK, FOXH1, EBI3, SRY, AHR, ID2, SRPK1, SUB1, GCM1, GTF2H1, DDIT3, MAX, PHOX2A, ITGB2, NRIP1, PRKCE, CARM1, HOXB9, RELB, ATF7IP2, E2F2, JUN, ZNF208, MBD2, HOXB7, GTF2F2, PAX3, TNFRSF1B, IL4, SREBF2, TCF4, BCL10, KPNA2, HNF4A, REL, EDA2R, SMARCA4, HOXC8, NR5A1, RXRG, CBX2, RNF2, DBP, TCEA2, ELA2, ZBTB16, FOSL1, TAF13, RB1, APP, GLI1, EP300, MDFI, DLGAP2, TLX1, DLX5, MDM4, SRF, TWIST1, MYF6, STAT3, SALL1, PCGF2, HOXB2, PAX5, PABPC1, POLR2A, SMAD2, NCOA1, IRF8, SETDB1, IRF2, HOXD10, ZEB2, GATA2, SMAD7, HAND2, DAXX, FOXO1, MDM2, SIX1, POU3F2, TGFB1I1, SOX10, PAX2, WT1, IKBKG, PER1, MEOX1, FHL2, MEOX2, YBX1, RYBP, CIITA, IKBKAP, CDK2, PPARA, KLF1, CEBPE, IL12A, FOS, SP4, CHAF1B, HOXD4, NOTCH1, SMAD1, IGFBP3, HCFC1, EYA1, CREB3, ADRB2, RFX1, ASCC2, IFI16, SAFB, ORC2L, TP73, FGF2, DNM2, AR, ERCC2, CCNT1, CDC6, HDAC1, CRK, STAT5A, DACH1, FABP4, SMAD3, CD28, RUNX1T1, LHX3, TAL1, CALR, ETS1, CREBBP, NEUROD1, ANKRD1, MYF5, FZD1, RHOH, PPARG, TRIP4, EGFR, NPM1, HEYL, PAWR, SMAD4, NOTCH4, TAF1, PPARGC1A, HCLS1, ZBTB33, ABL1, CHD1, CHAF1A, HOXA9, EAF2, MYOG, TBP, HIF1A, CAMK2A, NHLH1, MYT1, SERPINA5, CTNNB1, PRKCA, HOXA5, CITED2, PYCARD, RBL1, E2F1, NCOR1, NFE2, MIZF, MYC, CDC45L, MEIS1, TP53, ZMYND11, HAND1, SIX3, ZNF423, HIC1, ASCL1, NCOA2, 674 2873 15360 1.5626507305817696 6.852856138106489E-8 1.142142713739247E-9 2.495129658441897E-8 GOTERM_BP_ALL GO:0048732~gland development 12 1.70% 1.0099889540648663E-5 NOTCH4, STAT5A, ERBB2, GLI1, HOXA5, SIX1, POU1F1, POU3F2, AR, NR5A1, CRKL, GATA2, 674 51 15360 5.362192354686682 0.05168171330911797 3.560781168018279E-4 0.01931916729480676 GOTERM_BP_ALL GO:0043283~biopolymer metabolic process 336 47.59% 4.11304233731136E-16 KIT, PPP5C, MAFK, GATA4, POU2AF1, PTPN6, CRY1, STAT1, MMP14, UPF1, MAP2K7, CDK3, HMGB1, PPEF1, PPP1R3A, FYN, NRF1, PRM1, RAG1, PRKCG, ATG7, PLAT, POU1F1, PRKD3, ZBTB17, OTUD7B, RFXANK, DFFA, RCC1, ADRBK1, FOXH1, SRY, ID2, AHR, MAP3K14, SRPK1, SUB1, USP2, GCM1, GTF2H1, MAX, DDIT3, PHOX2A, ABI1, PTPRG, MAP3K3, NRIP1, ITGB2, HIST3H3, PRKCE, MAP3K5, CSNK1A1, CTBP1, GSPT2, CSNK2A1, DNMT3A, PTPN11, PPFIBP2, PPEF2, EXOSC4, PTPRT, CARM1, PRKDC, HOXB9, GJA1, RELB, RFXAP, E2F2, ATF7IP2, JUN, ZNF208, MBD2, PTPRZ1, HOXB7, PICK1, GTF2F2, PAX3, TNFRSF1B, WRN, GADD45G, IL4, MMP3, SREBF2, TCF4, MMP9, FGFR4, CDC25A, KPNA2, BCL10, GSK3A, MAPK1, HNF4A, IL27RA, REL, DDX5, SMARCA4, U2AF2, HOXC8, USP9X, NR5A1, CRKL, RXRG, RNF2, CBX2, DBP, ANAPC10, TCEA2, ELA2, EPHB1, ZBTB16, FOSL1, TAF13, RB1, APP, GLI1, SCG5, MOS, RAF1, EP300, MDFI, ACP1, EPB42, SIAH2, DLGAP2, CDC2, TLX1, LIPE, DLX5, MDM4, PRKAR2A, SRF, MMP7, IGF1R, BMPR1A, MYF6, TWIST1, FGR, STAT3, SALL1, CHRM3, PCGF2, PAX5, HOXB2, PABPC1, CBX1, DFFB, FER, BLK, NTRK1, POLR2A, PTPRN, SMAD2, PRKG1, NCOA1, SETDB1, IRF8, HCK, IRF2, HOXD10, ZEB2, GATA2, HAND2, SMAD7, CDK5, FOXO1, DAXX, MDM2, SIX1, FANCA, MAP3K8, POU3F2, TGFB1I1, PAX2, SOX10, XAB2, WT1, CBL, DYRK1A, IKBKG, SRC, PER1, FHL2, MEOX1, UBE2O, CDC14A, MEOX2, YBX1, PARP1, TNFRSF14, PCSK2, NEK2, RYBP, CDKN3, MAP3K7, ALK, CIITA, IKBKAP, AXIN1, CDK2, NUAK1, WNT2, PTK2, PPARA, TTN, KLF1, IL12A, CEBPE, UBE2I, PARK2, FOS, HOXD4, CHAF1B, SP4, SNF1LK2, BRSK2, NOTCH1, CAMK4, SMAD1, IGFBP3, HCFC1, PRKACA, CREB3, EYA1, DUSP6, ADRB2, PTPRH, RFX1, CASK, NMI, ASCC2, SAFB, IFI16, ORC2L, ERBB2, ERCC4, ATG12, TP73, FRK, FGF2, AXL, MAPK14, AR, ERCC2, EPHA3, EXOSC1, CCNT1, VCPIP1, CDC6, CTGF, HDAC1, CRK, STAT5A, DACH1, SMAD3, GNA14, MAPK8, EPHB2, RUNX1T1, FGFR1, TAL1, LHX3, MARK1, ETS1, CALR, CREBBP, ANKRD1, NEUROD1, MYF5, PPARG, TRIP4, EGFR, PAWR, HEYL, SMAD4, NOTCH4, TAF1, ACHE, PPARGC1A, MAP3K4, HCLS1, ROS1, ZBTB33, PIK3R1, CHD1, ABL1, CHAF1A, HOXA9, LRP2, EAF2, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, NEDD4, FES, CTNNB1, HOXA5, PRKCA, LIMK1, PFTK1, TEC, CBLC, CITED2, RBL1, PSMB9, PAK1, E2F1, STAMBPL1, NCOR1, PPP1CA, NFE2, MYC, MIZF, RAG2, TIE1, TRAF6, PTPRS, CDC45L, MEIS1, TP53, ZMYND11, SIX3, HAND1, CSF1R, LCK, ZNF423, HIC1, RAD52, COPS5, ASCL1, KDR, VCP, NCOA2, NTRK2, 674 5361 15360 1.4283176053894016 2.333244708552229E-12 6.139533326177116E-14 8.548717289613705E-13 GOTERM_BP_ALL GO:0048731~system development 172 24.36% 3.154751181890628E-25 KIT, CAPN3, MAFK, DYRK1A, KCNJ8, CAV3, GATA4, NFKBIA, BAI1, PLG, MMP14, COL1A2, FYN, WNT1, RAG1, MAP3K7, S100A7, LAMA3, DLG4, ALK, PLCE1, WNT2, POU1F1, PPARA, TTN, KLF1, CEBPE, ADRBK1, FOXH1, PARK2, FOS, ID2, BRSK2, NOTCH1, SMAD1, IGFBP3, KRT17, GCM1, ADRB2, DDIT3, NLGN1, FGF7, PLP1, IFI16, NRIP1, CSRP3, MPZ, ERBB2, TP73, FGF2, PTPN11, MAP3K7IP1, AR, ERCC2, PRKDC, GJA1, RELB, CTGF, ACTB, PTPRZ1, FGF1, GJA8, STAT5A, PICK1, PAX3, SGCG, ATP2B2, ACCN1, SMAD3, IL4, EPHB2, MMP9, FGFR1, BCL10, NAIP, MAPK1, TAL1, DCN, LHX3, ETS1, IL27RA, EDA2R, NEUROD1, MYF5, SMARCA4, RHOH, HOXC8, EGFR, RND1, HEYL, NR5A1, CRKL, PMP22, SMAD4, NRXN2, NOTCH4, PPP3R1, ACHE, CASP3, HCLS1, EPHB1, ZBTB16, PIK3R1, DCX, CD74, CSPG4, RB1, APP, LRP2, GLI1, MYOG, NHLH1, PTGS2, MYT1, SNTG2, EP300, CD44, LMO2, BMP1, EPB42, CTNNB1, HOXA5, LIMK1, TLX1, DLX5, CITED2, SRF, IGF1R, BMPR1A, PARD6B, MYF6, TWIST1, CASP8, STAT3, E2F1, SALL1, CHRM3, ERC2, PAX5, APBA2, PKP2, NTRK1, SMAD2, RAG2, PRKG1, TIE1, IRF8, HCK, FGD1, SH3GL2, ACTC1, ALPL, HOXD10, ZEB2, APBA1, SIX3, HAND1, GATA2, HAND2, CDK5, LCK, FOXO1, ZNF423, SIX1, POU3F2, BDNF, PLN, ASCL1, KDR, PAX2, PARD3, NTRK2, 674 1760 15360 2.227137847315889 1.657506270965336E-21 1.1839330506895256E-22 6.034991353342714E-22 GOTERM_BP_ALL GO:0014706~striated muscle development 19 2.69% 3.482831352983334E-7 ACTC1, TTN, ACTB, TWIST1, MYF6, CSRP3, CDK5, RB1, APP, PLG, MYOG, MYF5, SIX1, SMAD3, PLN, NOTCH1, IGFBP3, EP300, ADRB2, 674 101 15360 4.287099333078708 0.0018282067021926363 1.6943188978268964E-5 6.662582730188049E-4 GOTERM_BP_ALL GO:0006898~receptor-mediated endocytosis 9 1.27% 6.66591142748377E-4 SNX17, CUBN, CAP1, LRP2, SLC9A3, RAC1, CBL, ADRB2, CLTCL1, 674 45 15360 4.55786350148368 0.9699062471124537 0.01623792423107373 1.267502642506646 GOTERM_BP_ALL GO:0006897~endocytosis 20 2.83% 0.0010726242574185562 SLC9A3, VAV1, ELA2, SH3GL2, SYP, CEBPE, ELMO1, GATA2, SNX17, LRP1, CAP1, CUBN, APP, LRP2, BIN1, RAC1, DNM2, CBL, ADRB2, CLTCL1, 674 197 15360 2.3136362951693807 0.9964421271789758 0.02411398867031711 2.032084379208221 GOTERM_BP_ALL GO:0043269~regulation of ion transport 5 0.71% 0.005506908403653599 GJA1, CAV3, SLC9A3, PLN, ADRB2, 674 17 15360 6.702740443358353 0.999999999999749 0.09366838919251452 10.02492167178184 GOTERM_BP_ALL GO:0048699~generation of neurons 26 3.68% 9.523405057039384E-4 LIMK1, TLX1, NLGN1, DLX5, BAI1, TWIST1, PARD6B, FYN, PTPN11, HOXC8, RND1, PRKG1, GJA1, WNT2, PTPRZ1, GATA2, CDK5, APP, PICK1, ATP2B2, SIX1, POU3F2, BRSK2, ASCL1, PAX2, PARD3, 674 289 15360 2.050250017968437 0.9933022330205127 0.021716777617484695 1.8061706767532826 GOTERM_BP_ALL GO:0006878~cellular copper ion homeostasis 4 0.57% 0.003974573921295233 ATOX1, APP, CP, ATP7B, 674 8 15360 11.3946587537092 0.9999999991818873 0.07300923003173498 7.335477492856435 GOTERM_BP_ALL GO:0006873~cellular ion homeostasis 21 2.97% 0.0011842967832914467 CP, OPRL1, PRKCA, BCL2L1, CAV3, ELA2, SLC9A3R1, CCR1, CCR3, CALR, KCNA5, IREB2, CSRP3, LCK, ATOX1, APP, ATP2B2, PLN, ATP7B, MYC, PLCE1, 674 214 15360 2.2363348955877864 0.9980226203764038 0.02592791548751039 2.2413836816623123 GOTERM_BP_ALL GO:0043170~macromolecule metabolic process 400 56.66% 3.9262670158722704E-11 KIT, PPP5C, SLC2A2, CAPN3, PTPN6, CRY1, MMP14, CDK3, HMGB1, NRF1, FYN, PPP1R3A, RAG1, PRKCG, ATG7, PRKD3, RFXANK, DFFA, RCC1, AHR, ID2, MAP3K14, SUB1, GCM1, CLTCL1, GTF2H1, MAX, DDIT3, ABI1, ITGB2, NRIP1, PRKCE, CSNK1A1, MAP3K5, CTBP1, PPEF2, CARM1, PTPRT, PRKDC, HOXB9, RELB, ATF7IP2, E2F2, CTSB, JUN, PTPRZ1, HOXB7, PICK1, PAX3, CAV1, MMP3, MMP9, FGFR4, CDC25A, BCL10, HNF4A, IL27RA, REL, SMARCA4, U2AF2, NR5A1, CBX2, RNF2, ANAPC10, HSP90AA1, ELA2, FOSL1, TAF13, RB1, EP300, EPB42, DLGAP2, LIPE, DLX5, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, CAPN1, PTPRN, PRKG1, IRF8, SETDB1, IRF2, HOXD10, ZEB2, GATA2, DAXX, FOXO1, MAP3K8, TGFB1I1, XAB2, CBL, IKBKG, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, NEK2, RYBP, CTSS, CDKN3, MAP3K7, CIITA, ALK, NUAK1, CEBPE, DAG1, UBE2I, FOS, NOTCH1, SMAD1, IGFBP3, DUSP6, EYA1, PTPRH, ASCC2, IFI16, SAFB, ORC2L, ERCC4, FGF2, AXL, AR, CASP2, ERCC2, EPHA3, CTSF, VCPIP1, CDC6, TUBA1A, HDAC1, DACH1, SMAD3, KIFAP3, MAPK8, GNA14, EPHB2, LIN7A, LHX3, CALR, NEUROD1, EGFR, ACHE, CASP3, PPARGC1A, ROS1, PIK3R1, MYOG, SI, TBP, HIF1A, CAMK2A, NEDD4, LIMK1, CBLC, CITED2, RBL1, PSMB9, PAK1, E2F1, NCOR1, MIZF, RAG2, TIE1, TRAF6, CDC45L, APBA1, HAND1, SIX3, LCK, PLAU, ZNF423, RAD52, PARD3, NCOA2, MAFK, TUBA3C, GATA4, GZMB, POU2AF1, STAT1, MAP2K7, UPF1, PPEF1, PRM1, PLAT, POU1F1, SLC9A3R1, ZBTB17, OTUD7B, ADRBK1, FOXH1, EBI3, SRY, SRPK1, CASP5, USP2, PHOX2A, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, DNMT3A, PTPN11, PPFIBP2, EXOSC4, GJA1, RFXAP, ZNF208, MBD2, GTF2F2, TNFRSF1B, WRN, GADD45G, IL4, SLC9A3R2, SREBF2, TCF4, SPTA1, KPNA2, GSK3A, MAPK1, DDX5, HOXC8, USP9X, CRKL, RXRG, MPP6, DBP, TCEA2, EPHB1, ZBTB16, CD74, APP, GLI1, MOS, SCG5, RAF1, MDFI, MAGI1, ACP1, ACTN2, BMP1, SIAH2, CDC2, C1QA, HK3, TLX1, MMP7, SRF, PRKAR2A, NSF, MYF6, PEX6, CASP8, FGR, PCSK1, SALL1, CHRM3, PCGF2, HOXB2, PAX5, PABPC1, DFFB, CBX1, FER, NTRK1, BLK, POLR2A, SMAD2, NCOA1, CTSG, HCK, TRAF1, PRKAB1, CDK5, SMAD7, HAND2, MDM2, FANCA, SIX1, POU3F2, RAC1, SOX10, PAX2, WT1, DYRK1A, PER1, MEOX1, FHL2, MEOX2, YBX1, PARP1, PCSK2, DLG4, IKBKAP, AXIN1, CDK2, WNT2, PTK2, PPARA, KLF1, TTN, IL12A, PXN, PARK2, SP4, CHAF1B, HOXD4, SNF1LK2, BRSK2, CAMK4, GZMA, PRKACA, HCFC1, CREB3, ADRB2, RFX1, CASK, NMI, TJP1, ERBB2, ATG12, TP73, FRK, MAPK14, EXOSC1, CCNT1, REN, CTGF, CRK, STAT5A, CRYAA, CD28, RUNX1T1, FGFR1, TAL1, MARK1, ETS1, CREBBP, ANKRD1, ATOX1, PDE4DIP, MYF5, PPARG, TRIP4, NPM1, HEYL, PAWR, SMAD4, NOTCH4, TAF1, MAP3K4, APC2, HCLS1, ZBTB33, CASP1, ABL1, CHD1, CHAF1A, HOXA9, EAF2, LRP2, MME, LNPEP, NHLH1, MYT1, SERPINA5, FES, CTNNB1, PRKCA, HOXA5, PFTK1, TEC, PYCARD, PARD6B, STAMBPL1, PPP1CA, NFE2, STX12, WIPF1, MYC, PTPRS, MEIS1, TP53, ZMYND11, NCK1, CSF1R, HIC1, COPS5, ASCL1, KDR, CR2, VCP, NTRK2, 674 7216 15360 1.2632659372183146 2.0628622654506046E-7 3.2743848743521653E-9 7.510896349316454E-8 GOTERM_BP_ALL GO:0019538~protein metabolic process 231 32.72% 8.164607031089255E-10 KIT, PPP5C, CAPN3, TUBA3C, GZMB, PTPN6, CRY1, STAT1, MMP14, UPF1, MAP2K7, CDK3, PPEF1, FYN, PRKCG, ATG7, PLAT, PRKD3, SLC9A3R1, OTUD7B, ADRBK1, EBI3, MAP3K14, SRPK1, CASP5, USP2, CLTCL1, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, CSNK1A1, MAP3K5, CTBP1, GSPT2, CSNK2A1, PTPN11, PPEF2, CARM1, PTPRT, PRKDC, GJA1, CTSB, JUN, MBD2, PTPRZ1, PICK1, CAV1, IL4, MMP3, SLC9A3R2, MMP9, FGFR4, CDC25A, SPTA1, BCL10, GSK3A, MAPK1, REL, USP9X, CRKL, RNF2, MPP6, ANAPC10, HSP90AA1, ELA2, EPHB1, ZBTB16, CD74, MOS, SCG5, RAF1, EP300, MAGI1, ACP1, ACTN2, EPB42, BMP1, SIAH2, CDC2, C1QA, LIPE, HK3, MDM4, MMP7, PRKAR2A, IGF1R, NSF, BMPR1A, PEX6, CASP8, FGR, PCSK1, CHRM3, CAPN1, PCGF2, FER, NTRK1, BLK, PTPRN, PRKG1, CTSG, HCK, TRAF1, CDK5, MDM2, MAP3K8, FANCA, RAC1, CBL, DYRK1A, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, PARP1, PCSK2, NEK2, CTSS, CDKN3, MAP3K7, ALK, DLG4, IKBKAP, AXIN1, NUAK1, CDK2, WNT2, PTK2, TTN, CEBPE, IL12A, DAG1, UBE2I, PXN, PARK2, CHAF1B, SNF1LK2, BRSK2, CAMK4, IGFBP3, GZMA, PRKACA, HCFC1, DUSP6, ADRB2, PTPRH, CASK, TJP1, ERBB2, ATG12, FGF2, FRK, AXL, MAPK14, CASP2, EPHA3, CTSF, CCNT1, VCPIP1, REN, TUBA1A, HDAC1, STAT5A, SMAD3, KIFAP3, MAPK8, GNA14, CRYAA, EPHB2, CD28, FGFR1, LIN7A, MARK1, CALR, CREBBP, ATOX1, PDE4DIP, EGFR, SMAD4, TAF1, ACHE, CASP3, PPARGC1A, APC2, MAP3K4, HCLS1, ROS1, PIK3R1, CASP1, ABL1, CHAF1A, LRP2, MME, LNPEP, CAMK2A, MYT1, NEDD4, FES, SERPINA5, PRKCA, LIMK1, PFTK1, TEC, CBLC, PYCARD, PSMB9, PARD6B, PAK1, STAMBPL1, PPP1CA, STX12, WIPF1, TIE1, TRAF6, PTPRS, TP53, NCK1, APBA1, CSF1R, LCK, PLAU, COPS5, KDR, CR2, PARD3, VCP, NTRK2, 674 3691 15360 1.4262618109492413 4.289675197166609E-6 5.644321421360843E-8 1.5618769277914168E-6 GOTERM_BP_ALL GO:0012502~induction of programmed cell death 21 2.97% 0.0011842967832914467 PRKCA, MAPK1, IKBKG, CASP3, TP53, CADM1, PYCARD, ABL1, IL12A, IFI16, TIMP3, PRKCE, LCK, MAP3K5, DAXX, PLG, TRAIP, TP73, TRAF3, SMAD3, ERCC2, 674 214 15360 2.2363348955877864 0.9980226203764038 0.02592791548751039 2.2413836816623123 GOTERM_BP_ALL GO:0048646~anatomical structure formation 21 2.97% 1.1525962179940301E-4 NOTCH4, SMAD2, TIE1, CTNNB1, FGFR1, TLX1, CTGF, FGF1, HAND1, HAND2, CSPG4, CASP8, PLG, ERBB2, MMP14, ATP2B2, FGF2, SMAD3, KDR, MAP3K7, S100A7, 674 179 15360 2.6736070818759012 0.45425800673874706 0.003454641545473258 0.22025969464135597 GOTERM_BP_ALL GO:0012501~programmed cell death 97 13.74% 2.1921371601307398E-20 IKBKG, GZMB, NFKBIA, PTPN6, STAT1, PLG, TNFRSF14, HMGB1, RYBP, MAP3K7, AXIN1, DFFA, IL12A, ELMO1, TIMP3, AHR, TRAF3, IGFBP3, GZMA, CASP5, ADRB2, DDIT3, SERPINB2, IFI16, ITGB2, PRKCE, MAP3K5, ATG12, TP73, FGF2, DNM2, CASP2, ERCC2, PRKDC, GJA1, AGTR2, E2F2, CTSB, ATG5, HDAC1, STAT5A, PAX3, SMAD3, TNFRSF1B, WRN, GADD45G, IL4, MAPK8, CRYAA, MMP9, CD28, BCL10, NAIP, MAPK1, CALR, IAPP, NPM1, PAWR, SEPT4, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, CD74, APP, TRAIP, EAF2, RAF1, EP300, ACTN2, SIAH2, BCL2L1, PRKCA, CDC2, CADM1, MDM4, PYCARD, IGF1R, ACTN3, PAK1, CASP8, E2F1, MIF, SFRP1, DFFB, TRAF6, CARD9, TP53, ACTC1, TRAF1, CDK5, LCK, DAXX, FOXO1, YWHAZ, VCP, 674 791 15360 2.79464449838127 1.1517488639326906E-16 5.235222108784958E-18 4.1935252715562407E-17 GOTERM_BP_ALL GO:0002682~regulation of immune system process 12 1.70% 0.004661973746957941 LCK, TRAF6, BCL10, IKBKG, C1QA, FYN, SMAD3, IL4, CR2, MAP3K7, IL12A, IL27RA, 674 101 15360 2.707641684049711 0.9999999999782473 0.08171502996005575 8.551241406125209 GOTERM_BP_ALL GO:0010468~regulation of gene expression 184 26.06% 9.41344363189928E-10 MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, UPF1, HMGB1, NRF1, RYBP, CIITA, IKBKAP, CDK2, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, EBI3, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, NOTCH1, SMAD1, HCFC1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, ASCC2, SAFB, IFI16, NRIP1, ORC2L, DNMT3A, TP73, DNM2, AR, CARM1, ERCC2, HOXB9, CCNT1, RELB, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PICK1, PAX3, DACH1, FABP4, SMAD3, IL4, SREBF2, TCF4, CD28, RUNX1T1, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, EDA2R, NEUROD1, MYF5, SMARCA4, FZD1, PPARG, RHOH, TRIP4, HOXC8, NPM1, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, TCEA2, PPARGC1A, HCLS1, ELA2, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, PYCARD, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, ASCL1, PAX2, SOX10, WT1, NCOA2, 674 2760 15360 1.519287833827893 4.9458109121491844E-6 6.423146736711516E-8 1.8007774826855893E-6 GOTERM_BP_ALL GO:0010467~gene expression 199 28.19% 5.628781416228954E-4 PPP5C, MAFK, GATA4, POU2AF1, CRY1, STAT1, UPF1, HMGB1, NRF1, POU1F1, ZBTB17, RFXANK, EBI3, FOXH1, SRY, AHR, ID2, SRPK1, SUB1, GCM1, GTF2H1, DDIT3, MAX, PHOX2A, NRIP1, GSPT2, DNMT3A, EXOSC4, CARM1, HOXB9, RELB, RFXAP, ATF7IP2, E2F2, JUN, ZNF208, MBD2, HOXB7, PICK1, GTF2F2, PAX3, IL4, SREBF2, TCF4, BCL10, HNF4A, REL, EDA2R, SMARCA4, DDX5, U2AF2, HOXC8, NR5A1, RXRG, CBX2, RNF2, DBP, TCEA2, ELA2, ZBTB16, FOSL1, TAF13, RB1, APP, GLI1, EP300, MDFI, DLGAP2, TLX1, DLX5, MDM4, SRF, TWIST1, MYF6, STAT3, SALL1, PCGF2, HOXB2, PAX5, PABPC1, POLR2A, SMAD2, NCOA1, IRF8, SETDB1, IRF2, HOXD10, ZEB2, GATA2, SMAD7, HAND2, DAXX, FOXO1, MDM2, SIX1, POU3F2, TGFB1I1, SOX10, PAX2, XAB2, WT1, IKBKG, PER1, MEOX1, FHL2, MEOX2, YBX1, PARP1, RYBP, CIITA, IKBKAP, CDK2, PPARA, KLF1, CEBPE, FOS, SP4, CHAF1B, HOXD4, NOTCH1, SMAD1, HCFC1, EYA1, CREB3, ADRB2, RFX1, NMI, ASCC2, IFI16, SAFB, ORC2L, TP73, DNM2, AR, ERCC2, EXOSC1, CCNT1, REN, HDAC1, CRK, STAT5A, DACH1, FABP4, SMAD3, CD28, RUNX1T1, LHX3, TAL1, CALR, ETS1, CREBBP, NEUROD1, ANKRD1, PDE4DIP, MYF5, FZD1, RHOH, PPARG, TRIP4, NPM1, HEYL, PAWR, SMAD4, NOTCH4, TAF1, PPARGC1A, HCLS1, ZBTB33, ABL1, CHD1, CHAF1A, HOXA9, EAF2, MYOG, TBP, HIF1A, CAMK2A, NHLH1, MYT1, CTNNB1, HOXA5, CITED2, PYCARD, RBL1, E2F1, NCOR1, NFE2, MIZF, MYC, MEIS1, TP53, ZMYND11, HAND1, SIX3, ZNF423, HIC1, COPS5, ASCL1, NCOA2, 674 3686 15360 1.2303511079696856 0.9480874333270167 0.014054342625438698 1.0713007996971724 GOTERM_BP_ALL GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade 13 1.84% 0.0018063433355284492 PPP5C, BCL10, TRAF6, GJA1, CARD9, OTUD7B, CASP1, MAP3K3, REL, CASP8, RHOH, TRAF3IP2, TICAM1, 674 103 15360 2.876321627149895 0.9999250815071145 0.03670739893246955 3.399505132436298 GOTERM_BP_ALL GO:0006816~calcium ion transport 15 2.12% 5.948065181580149E-4 CCL8, GJA1, TRPC3, SCN3A, ACCN2, CAV3, SLC8A1, CACNA1B, ITPR1, TRPV6, ATP2B2, FYN, PLN, TRPV1, ADRB2, 674 117 15360 2.921707372745949 0.956108878980586 0.014569087953162696 1.131741492820626 GOTERM_BP_ALL GO:0051726~regulation of cell cycle 66 9.35% 3.605108445358246E-14 CD28, CDC25A, BCL10, CDK5R2, RAP1A, FGF8, CALR, CDC14A, STAT1, BIN1, CDK3, NEK2, EGFR, CDKN3, AXIN1, CDK2, ANAPC10, CASP3, APC2, ZBTB17, ABL1, RCC1, ACPP, RB1, SRPK1, MOS, C13orf15, HCFC1, DUSP6, NEDD9, ADCYAP1, GTF2H1, PRKCA, DDIT3, CDC2, CADM1, CITED2, PYCARD, MDM4, FGF7, IGF1R, RBL1, TP73, FRK, FGF2, PTPN11, AXL, ERCC2, MYC, CDC45L, CCNT1, TP53, ZMYND11, E2F2, STARD13, CDC6, FGF1, LCK, STAT5A, MDM2, HIC1, GADD45G, COPS5, EPHB2, WT1, PLEKHO1, 674 529 15360 2.843279689016284 1.895761325698686E-10 4.212852289242619E-12 6.902256544094598E-11 GOTERM_BP_ALL GO:0006796~phosphate metabolic process 111 15.72% 8.270798906026792E-19 KIT, PPP5C, DYRK1A, SRC, PTPN6, CDC14A, STAT1, TNFRSF14, MAP2K7, CDK3, PPEF1, FYN, NEK2, CDKN3, PRKCG, MAP3K7, ALK, IKBKAP, NUAK1, CDK2, WNT2, PRKD3, PTK2, TTN, IL12A, ADRBK1, SLC34A1, MAP3K14, SRPK1, SNF1LK2, BRSK2, CAMK4, IGFBP3, PRKACA, DUSP6, PTPRH, CASK, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, MAP3K5, CSNK1A1, CTBP1, CSNK2A1, ERBB2, FGF2, PTPN11, FRK, PPEF2, AXL, MAPK14, PTPRT, EPHA3, CCNT1, JUN, PTPRZ1, PICK1, IL4, MAPK8, EPHB2, FGFR4, CDC25A, BCL10, FGFR1, GSK3A, MAPK1, INPPL1, MARK1, EGFR, CRKL, TAF1, MAP3K4, HCLS1, ROS1, EPHB1, PIK3R1, ABL1, MOS, CAMK2A, RAF1, ACP1, FES, PRKCA, LIMK1, PFTK1, CDC2, TEC, LIPE, CBLC, PRKAR2A, IGF1R, BMPR1A, PAK1, FGR, PPP1CA, FER, NTRK1, BLK, PTPRN, PRKG1, TIE1, PTPRS, HCK, CSF1R, CDK5, LCK, MAP3K8, KDR, NTRK2, 674 1036 15360 2.4417125900805425 4.345477745226477E-15 1.4484925817421589E-16 1.5821913363447798E-15 GOTERM_BP_ALL GO:0002573~myeloid leukocyte differentiation 9 1.27% 1.9815475641674868E-4 CASP8, RB1, CTNNB1, ID2, RELB, IL4, CEBPE, IFI16, MMP9, 674 38 15360 5.397469935967515 0.6469721231091209 0.005552486224930986 0.3783869231783754 GOTERM_BP_ALL GO:0006793~phosphorus metabolic process 111 15.72% 8.270798906026792E-19 KIT, PPP5C, DYRK1A, SRC, PTPN6, CDC14A, STAT1, TNFRSF14, MAP2K7, CDK3, PPEF1, FYN, NEK2, CDKN3, PRKCG, MAP3K7, ALK, IKBKAP, NUAK1, CDK2, WNT2, PRKD3, PTK2, TTN, IL12A, ADRBK1, SLC34A1, MAP3K14, SRPK1, SNF1LK2, BRSK2, CAMK4, IGFBP3, PRKACA, DUSP6, PTPRH, CASK, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, MAP3K5, CSNK1A1, CTBP1, CSNK2A1, ERBB2, FGF2, PTPN11, FRK, PPEF2, AXL, MAPK14, PTPRT, EPHA3, CCNT1, JUN, PTPRZ1, PICK1, IL4, MAPK8, EPHB2, FGFR4, CDC25A, BCL10, FGFR1, GSK3A, MAPK1, INPPL1, MARK1, EGFR, CRKL, TAF1, MAP3K4, HCLS1, ROS1, EPHB1, PIK3R1, ABL1, MOS, CAMK2A, RAF1, ACP1, FES, PRKCA, LIMK1, PFTK1, CDC2, TEC, LIPE, CBLC, PRKAR2A, IGF1R, BMPR1A, PAK1, FGR, PPP1CA, FER, NTRK1, BLK, PTPRN, PRKG1, TIE1, PTPRS, HCK, CSF1R, CDK5, LCK, MAP3K8, KDR, NTRK2, 674 1036 15360 2.4417125900805425 4.345477745226477E-15 1.4484925817421589E-16 1.5821913363447798E-15 GOTERM_BP_ALL GO:0043086~negative regulation of catalytic activity 11 1.56% 0.004289404613757129 RB1, PRKCA, FABP4, CASP3, CAV1, CAV3, TP53, GADD45G, ADRA2A, DUSP6, GNAI3, 674 86 15360 2.914912704437237 0.9999999998445979 0.07696550177869421 7.894189171549016 GOTERM_BP_ALL GO:0045944~positive regulation of transcription from RNA polymerase II promoter 37 5.24% 2.3070979842767297E-15 CTNNB1, GTF2H1, TLX1, SRF, HNF4A, NRIP1, NEUROD1, E2F1, PPARG, NR5A1, SMAD4, ERCC2, SMAD2, PPARGC1A, POU1F1, TP53, JUN, PPARA, FOSL1, HAND1, HAND2, RB1, FOXH1, FOXO1, APP, STAT5A, GLI1, MYOG, SMAD3, HIF1A, NOTCH1, SOX10, SMAD1, IL4, EP300, NCOA2, ADRB2, 674 171 15360 4.931021916809828 1.2249534719899202E-11 2.916555885690286E-13 4.463096558993129E-12 GOTERM_BP_ALL GO:0033674~positive regulation of kinase activity 25 3.54% 6.557679225085785E-9 KIT, IKBKG, GRM1, GAB1, MAP3K5, ERBB2, FGF2, PTPN11, EGFR, MAP3K7IP1, MAP3K7, PLCE1, TRAF6, PRKD3, MAP3K4, ELA2, ADRA2A, DAXX, PICK1, GADD45G, GNB2L1, PARD3, MDFI, IRS1, ADRB2, 674 138 15360 4.128499548445362 3.4453452977478705E-5 3.871240431552181E-7 1.2544740457531844E-5 GOTERM_BP_ALL GO:0043085~positive regulation of catalytic activity 34 4.82% 4.7338538157454625E-9 KIT, IKBKG, GRM1, PYCARD, GAB1, MAP3K5, STAT1, CAP1, ERBB2, FGF2, PTPN11, MAP3K7IP1, EGFR, MAP3K7, PLCE1, TRAF6, MAP3K4, PRKD3, TP53, ELA2, ADRA2A, ABL1, LCK, DAXX, PICK1, SMAD3, GADD45G, GNB2L1, PARD3, VCP, MDFI, IRS1, ADRB2, ADCYAP1, 674 239 15360 3.241994959214333 2.487135896533932E-5 2.892054030700919E-7 9.055790539669317E-6 GOTERM_BP_ALL GO:0045941~positive regulation of transcription 52 7.37% 1.6061354773582249E-15 BCL10, GATA4, HNF4A, FHL2, REL, CREBBP, NEUROD1, PPARG, NR5A1, SMAD4, NOTCH4, CDK2, PPARGC1A, POU1F1, FOSL1, PPARA, RB1, FOXH1, APP, GLI1, MYOG, HIF1A, NOTCH1, SMAD1, EP300, ADRB2, CTNNB1, GTF2H1, DDIT3, TLX1, CITED2, SRF, MYF6, NRIP1, E2F1, TP73, ERCC2, SMAD2, NCOA1, TP53, JUN, HAND1, HAND2, FOXO1, STAT5A, ZNF423, SMAD3, TGFB1I1, IL4, SOX10, NCOA2, TCF4, 674 326 15360 3.635105860079008 8.166356479932801E-12 1.9917401061775308E-13 2.9753977059954195E-12 GOTERM_BP_ALL GO:0043069~negative regulation of programmed cell death 24 3.40% 2.3921087070827461E-4 CD28, BCL10, NAIP, CASP3, BCL2L1, CDC2, SERPINB2, PIK3R1, IGF1R, HDAC1, CD74, FOXO1, YWHAZ, STAT5A, HMGB1, TP73, MIF, SFRP1, NPM1, IL4, CRYAA, MAPK8, MAP3K7, CASP2, 674 233 15360 2.3473975114937407 0.7154835653936253 0.006593766456955752 0.4566158484633709 GOTERM_BP_ALL GO:0043068~positive regulation of programmed cell death 29 4.11% 8.020009435541457E-6 PRKCA, IKBKG, DDIT3, MAPK1, CADM1, PYCARD, IFI16, PRKCE, MAP3K5, PLG, TP73, DNM2, PAWR, ERCC2, CASP3, TP53, ZBTB16, ABL1, IL12A, TIMP3, CDK5, LCK, DAXX, TRAIP, TRAF3, SMAD3, IGFBP3, MMP9, ADRB2, 674 256 15360 2.5816023738872405 0.04126186181628266 2.8660720972906173E-4 0.0153410415593358 GOTERM_BP_ALL GO:0051674~localization of cell 47 6.66% 1.0543763241781173E-8 PRKCA, AKAP3, LIMK1, PARD6B, TWIST1, ITGB2, STAT3, GAB1, CAP1, PLG, MMP14, FYN, WNT1, EGFR, MAPK14, CRKL, IL16, LAMA3, MSN, PRKG1, TIE1, LAMA1, WNT2, DOCK2, ELA2, ADRA2A, NCK1, CTGF, ARHGDIB, ZEB2, VIM, ACTB, IL12A, CRK, ELMO1, ITGB3, CDK5, CSPG4, ROPN1B, PXN, SIX1, RAC1, PTGS2, ASCL1, KDR, F11R, MAPK8, 674 421 15360 2.544175588714168 5.5395397741464514E-5 5.956657593841896E-7 2.0170057790647178E-5 GOTERM_BP_ALL GO:0043067~regulation of programmed cell death 66 9.35% 1.365512118048906E-13 CD28, BCL10, NAIP, IKBKG, MAPK1, CALR, STAT1, PLG, HMGB1, NPM1, PAWR, MAP3K7, SEPT4, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, IL12A, CD74, TIMP3, TRAIP, TRAF3, IGFBP3, CASP5, ADRB2, ACTN2, PRKCA, DDIT3, BCL2L1, CDC2, CADM1, SERPINB2, PYCARD, IGF1R, ACTN3, IFI16, PRKCE, CASP8, MAP3K5, TP73, FGF2, MIF, DNM2, SFRP1, CASP2, ERCC2, TRAF6, CARD9, TP53, CTSB, TRAF1, HDAC1, CDK5, LCK, DAXX, FOXO1, YWHAZ, STAT5A, SMAD3, WRN, IL4, CRYAA, MAPK8, VCP, MMP9, 674 544 15360 2.7648804328853203 7.174727478798104E-10 1.4349410548675223E-11 2.6123547769429933E-10 GOTERM_BP_ALL GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 53 7.51% 1.3827133434181023E-15 BCL10, GATA4, HNF4A, FHL2, REL, CREBBP, NEUROD1, PPARG, PRKCG, NR5A1, SMAD4, NOTCH4, CDK2, PPARGC1A, POU1F1, FOSL1, PPARA, RB1, FOXH1, APP, GLI1, MYOG, HIF1A, NOTCH1, SMAD1, EP300, ADRB2, CTNNB1, GTF2H1, DDIT3, TLX1, CITED2, SRF, MYF6, NRIP1, E2F1, TP73, ERCC2, SMAD2, NCOA1, TP53, JUN, HAND1, HAND2, FOXO1, STAT5A, ZNF423, SMAD3, TGFB1I1, IL4, SOX10, NCOA2, TCF4, 674 336 15360 3.5947435353963546 6.999734125656687E-12 1.7497114868092467E-13 2.55351295663786E-12 GOTERM_BP_ALL GO:0043066~negative regulation of apoptosis 24 3.40% 1.98068586469473E-4 CD28, BCL10, NAIP, CASP3, BCL2L1, CDC2, SERPINB2, PIK3R1, IGF1R, HDAC1, CD74, FOXO1, YWHAZ, STAT5A, HMGB1, TP73, MIF, SFRP1, NPM1, IL4, CRYAA, MAPK8, MAP3K7, CASP2, 674 230 15360 2.3780157399045283 0.6468122264912409 0.005609910365958148 0.3782226724354243 GOTERM_BP_ALL GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 41 5.81% 4.443198494204477E-9 CTNNB1, MDM4, PER1, RBL1, MYF6, TWIST1, NRIP1, STAT3, ORC2L, E2F1, SMARCA4, HMGB1, FZD1, NCOR1, PPARG, RYBP, PAWR, SMAD4, RNF2, CBX2, IRF8, CDC45L, IRF2, TP53, ZMYND11, ZBTB16, CDC6, MBD2, ZEB2, SIX3, HAND1, RB1, DAXX, MDM2, ZNF423, ID2, FABP4, SMAD3, MDFI, TCF4, NCOA2, 674 328 15360 2.8486646884272995 2.3344292361504593E-5 2.7464190166526237E-7 8.499771220193963E-6 GOTERM_BP_ALL GO:0002521~leukocyte differentiation 18 2.55% 6.39901188050933E-6 RAG2, CTNNB1, RELB, PIK3R1, CEBPE, IFI16, CD74, CASP8, RB1, LCK, STAT5A, ERBB2, ID2, RHOH, IL4, RAG1, NTRK1, MMP9, 674 111 15360 3.6955650012029833 0.03306162732534634 2.4359725282818712E-4 0.012240503015248372 GOTERM_BP_ALL GO:0008632~apoptotic program 14 1.98% 5.352019209778515E-5 CASP3, BCL2L1, TP53, GZMB, PYCARD, DFFA, LCK, CASP8, STAT1, SMAD3, DFFB, GZMA, CASP2, VCP, 674 82 15360 3.890859086632409 0.24512462860437 0.0017028068453635026 0.10233366221791274 GOTERM_BP_ALL GO:0043065~positive regulation of apoptosis 29 4.11% 6.896055999497469E-6 PRKCA, IKBKG, DDIT3, MAPK1, CADM1, PYCARD, IFI16, PRKCE, MAP3K5, PLG, TP73, DNM2, PAWR, ERCC2, CASP3, TP53, ZBTB16, ABL1, IL12A, TIMP3, CDK5, LCK, DAXX, TRAIP, TRAF3, SMAD3, IGFBP3, MMP9, ADRB2, 674 254 15360 2.601929951634384 0.03558348014474988 2.533385557678125E-4 0.01319122631888714 GOTERM_BP_ALL GO:0002520~immune system development 34 4.82% 4.303080300685132E-10 KIT, EPB42, CTNNB1, TAL1, TLX1, NFKBIA, ETS1, IL27RA, IFI16, CASP8, ERBB2, RHOH, RAG1, CRKL, NTRK1, NOTCH4, RAG2, IRF8, RELB, HCLS1, PIK3R1, ZBTB16, KLF1, CEBPE, CD74, RB1, LCK, STAT5A, ID2, SIX1, KDR, IL4, MMP9, LMO2, 674 218 15360 3.55429722592764 2.2608357369557908E-6 3.055186836853352E-8 8.231727188778848E-7 GOTERM_BP_ALL GO:0031098~stress-activated protein kinase signaling pathway 14 1.98% 9.231151481267092E-6 CARD9, MAP3K4, SH2D3C, EDA2R, PAK1, GAB1, MAP3K5, DAXX, MAP2K7, MAPK8IP1, MAPK8, MAP3K7, CRKL, MDFI, 674 70 15360 4.557863501483679 0.04734332159165111 3.276536999420321E-4 0.017657575705865014 GOTERM_BP_ALL GO:0048583~regulation of response to stimulus 8 1.13% 0.0013576916676285653 STAT5A, PRKCA, FABP4, ELA2, TNFRSF1B, PTGS2, IL12A, ADRB2, 674 39 15360 4.674731796393518 0.9992057869663377 0.02930437802910979 2.5655248598482006 GOTERM_BP_ALL GO:0051649~establishment of cellular localization 59 8.36% 0.0012213773987298326 KPNA2, PEX26, TUBA3C, LIN7A, NFKBIA, HAP1, CALR, SNX17, STAT1, UPF1, STXBP1, KIFC3, NPM1, ATP7B, NRXN2, EXOC2, CCL8, ACHE, POU1F1, HSP90AA1, CD74, CACNA1B, PARK2, SCG5, CAMK4, MDFI, CLTCL1, ADRB2, LCP2, BCL2L1, AKAP3, CADM1, NLGN1, RPGR, PYCARD, PEX6, TRPV6, PTPN11, MYH4, STX12, WIPF1, EXOC3, STX1A, TP53, TNNT2, PEX19, KIF5A, APBA1, TUBA1A, ROPN1B, GABARAPL2, SNAP25, YWHAZ, PICK1, ARF1, SMAD3, CRYAA, VCP, AKAP5, 674 881 15360 1.5261858489644555 0.9983730349098235 0.02650858371056275 2.3107872837203725 GOTERM_BP_ALL GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 12 1.70% 7.022187550893254E-4 EBI3, TRAF6, BCL10, C1QA, RELB, CADM1, IL4, CR2, MAP3K7, IL12A, IL27RA, CD74, 674 80 15360 3.41839762611276 0.9750468035076889 0.01678755310468616 1.3348169878054872 GOTERM_BP_ALL GO:0010324~membrane invagination 20 2.83% 0.0010726242574185562 SLC9A3, VAV1, ELA2, SH3GL2, SYP, CEBPE, ELMO1, GATA2, SNX17, LRP1, CAP1, CUBN, APP, LRP2, BIN1, RAC1, DNM2, CBL, ADRB2, CLTCL1, 674 197 15360 2.3136362951693807 0.9964421271789758 0.02411398867031711 2.032084379208221 GOTERM_BP_ALL GO:0002449~lymphocyte mediated immunity 10 1.42% 0.004896482435514278 TRAF6, BCL10, C1QA, CADM1, IL4, CR2, MAP3K7, IL12A, IL27RA, CD74, 674 74 15360 3.079637501002486 0.9999999999936927 0.08425571564331147 8.962533541299555 GOTERM_BP_ALL GO:0051641~cellular localization 60 8.50% 0.0014325840870642189 KPNA2, PEX26, TUBA3C, LIN7A, NFKBIA, HAP1, CALR, SNX17, STAT1, UPF1, STXBP1, KIFC3, EGFR, NPM1, ATP7B, NRXN2, EXOC2, CCL8, ACHE, POU1F1, HSP90AA1, CD74, CACNA1B, PARK2, SCG5, CAMK4, MDFI, CLTCL1, ADRB2, LCP2, BCL2L1, AKAP3, CADM1, NLGN1, RPGR, PYCARD, PEX6, TRPV6, PTPN11, MYH4, STX12, WIPF1, EXOC3, STX1A, TP53, TNNT2, PEX19, KIF5A, APBA1, TUBA1A, ROPN1B, GABARAPL2, SNAP25, YWHAZ, PICK1, ARF1, SMAD3, CRYAA, VCP, AKAP5, 674 906 15360 1.509226324994596 0.9994644376987849 0.029915159919839396 2.7052121445066524 GOTERM_BP_ALL GO:0043009~chordate embryonic development 20 2.83% 5.626461294673465E-7 BCL10, SETDB1, ZEB2, MEOX1, MYF6, HAND2, MEOX2, CASP8, PLCG1, MYF5, SIX1, SMARCA4, SFRP1, MAP3K7IP1, XAB2, EP300, MAP3K7, GNA12, PRKDC, GRN, 674 115 15360 3.9633595665075476 0.002951778505698055 2.639379092639338E-5 0.0010763280563375055 GOTERM_BP_ALL GO:0045893~positive regulation of transcription, DNA-dependent 47 6.66% 5.600879137476742E-16 CTNNB1, BCL10, GTF2H1, TLX1, GATA4, CITED2, SRF, HNF4A, FHL2, REL, NRIP1, NEUROD1, E2F1, TP73, PPARG, NR5A1, SMAD4, ERCC2, NOTCH4, SMAD2, NCOA1, POU1F1, PPARGC1A, TP53, JUN, PPARA, FOSL1, HAND1, HAND2, FOXH1, RB1, APP, FOXO1, STAT5A, GLI1, MYOG, TGFB1I1, SMAD3, HIF1A, NOTCH1, SOX10, IL4, SMAD1, EP300, TCF4, NCOA2, ADRB2, 674 263 15360 4.072615676230664 2.9165558856902862E-12 7.482903185973555E-14 1.0658141036401503E-12 GOTERM_BP_ALL GO:0045892~negative regulation of transcription, DNA-dependent 31 4.39% 1.8673001359307758E-8 CTNNB1, MDM4, RBL1, TWIST1, NRIP1, STAT3, ORC2L, E2F1, SMARCA4, HMGB1, NCOR1, PPARG, RYBP, PAWR, SMAD4, RNF2, CBX2, IRF8, IRF2, ZMYND11, ZBTB16, MBD2, HAND1, RB1, DAXX, MDM2, ID2, SMAD3, MDFI, NCOA2, TCF4, 674 215 15360 3.285901594092885 9.81031376726671E-5 1.0011010305177592E-6 3.572116348271592E-5 GOTERM_BP_ALL GO:0002376~immune system process 84 11.90% 6.664605410793727E-6 CD28, CXCL2, KIT, BCL10, OPRD1, IKBKG, INPPL1, TAL1, NFKBIA, POU2AF1, ETS1, IL27RA, TNFRSF14, SH2D1A, FYN, RHOH, CTSS, RAG1, CRKL, MAP3K7, DEFB1, S100A7, CIITA, NOTCH4, IKBKAP, CCL8, CASP3, DOCK2, HCLS1, ELA2, ZBTB16, CCR1, PIK3R1, RFXANK, KLF1, ARHGDIB, IL12A, CEBPE, CD74, SLAMF1, EBI3, RB1, IL4R, ID2, NOTCH1, GZMA, LMO2, EPB42, CTNNB1, LCP2, PRKCA, RFX1, C1QA, TLX1, CADM1, VAV1, HLA-DRA, PSMB9, IFI16, ITGB2, CASP8, ERBB2, PAX5, MIF, IL16, NTRK1, RAG2, FCGR2B, CTSG, TRAF6, IRF8, RELB, IRF2, C1QBP, NCK1, GJA8, LCK, STAT5A, SIX1, SMAD3, KDR, IL4, CR2, MMP9, 674 1165 15360 1.6431782580456182 0.034409988417201665 2.5008267777015813E-4 0.01274851926305054 GOTERM_BP_ALL GO:0048534~hemopoietic or lymphoid organ development 33 4.67% 4.0529792583312266E-10 KIT, EPB42, CTNNB1, TAL1, TLX1, NFKBIA, ETS1, IFI16, CASP8, ERBB2, RHOH, RAG1, CRKL, NTRK1, NOTCH4, RAG2, IRF8, RELB, HCLS1, PIK3R1, ZBTB16, KLF1, CEBPE, CD74, RB1, LCK, STAT5A, ID2, SIX1, KDR, IL4, MMP9, LMO2, 674 206 15360 3.6507159113825587 2.129432933095643E-6 2.9170344806317416E-8 7.753287678546883E-7 GOTERM_BP_ALL GO:0045860~positive regulation of protein kinase activity 24 3.40% 1.752900799095893E-8 KIT, TRAF6, IKBKG, MAP3K4, PRKD3, ELA2, GRM1, ADRA2A, GAB1, MAP3K5, DAXX, PICK1, ERBB2, PTPN11, FGF2, GADD45G, MAP3K7IP1, EGFR, GNB2L1, MAP3K7, PARD3, MDFI, ADRB2, PLCE1, 674 134 15360 4.081668807298818 9.209316812319734E-5 9.494573736112955E-7 3.353272221007231E-5 GOTERM_BP_ALL GO:0045859~regulation of protein kinase activity 38 5.38% 5.8598818864079396E-12 CDC25A, KIT, GTF2H1, CDK5R2, PRKCA, IKBKG, CAV3, GRM1, GAB1, MAP3K5, ERBB2, PTPN11, FGF2, MAP3K7IP1, EGFR, CDKN3, MAP3K7, PLCE1, TRAF6, CCNT1, CASP3, MAP3K4, PRKD3, ELA2, ADRA2A, CDC6, RB1, DAXX, PICK1, FABP4, CAV1, GADD45G, C13orf15, GNB2L1, PARD3, MDFI, DUSP6, ADRB2, 674 230 15360 3.76519158818217 3.078774679643459E-8 5.308232742251562E-10 1.1209844164028482E-8 GOTERM_BP_ALL GO:0048523~negative regulation of cellular process 124 17.56% 6.895229310409616E-22 RAP1A, CAV3, NFKBIA, BAI1, PTPN6, PER1, BIN1, PLG, MMP14, TAX1BP3, HMGB1, RYBP, CDKN3, MAP3K7, AXIN1, WNT2, POU1F1, ZBTB17, OTUD7B, ARHGDIB, RGS19, ADRBK1, LRP1, ID2, NOTCH1, SMAD1, IGFBP3, ADRB2, DDIT3, RGS2, SERPINB2, ABI1, NRIP1, ORC2L, CTBP1, ERCC4, TP73, FRK, FGF2, CASP2, GJA1, JUN, CDC6, MBD2, HDAC1, STAT5A, FABP4, CAV1, SMAD3, IL4, CRYAA, MAPK8, EPHB2, TCF4, PLEKHO1, CD28, SPTA1, BCL10, NAIP, MAPK1, ETS1, IAPP, SMARCA4, FZD1, PPARG, RHOH, EGFR, NPM1, RND1, PAWR, PMP22, SMAD4, NOTCH4, CBX2, RNF2, CASP3, ELA2, PIK3R1, ZBTB16, CD74, RB1, PTGS2, MDFI, LMO2, ADCYAP1, SERPINA5, CTNNB1, PRKCA, BCL2L1, CDC2, CADM1, CBLC, PYCARD, MDM4, IGF1R, RBL1, TWIST1, MYF6, STAT3, E2F1, NCOR1, MIF, SFRP1, MYC, TIE1, IRF8, CDC45L, IRF2, TP53, ZMYND11, STARD13, ZEB2, SIX3, HAND1, FOXO1, DAXX, YWHAZ, ZNF423, MDM2, HIC1, TGFB1I1, RAC1, WT1, NCOA2, 674 1132 15360 2.496356334734877 3.622753479689212E-18 1.811376739844606E-19 1.3190469507233531E-18 GOTERM_BP_ALL GO:0048522~positive regulation of cellular process 118 16.71% 1.2709446739068824E-23 KIT, PPP5C, IKBKG, GATA4, FHL2, PLG, PRKCG, MAP3K7, TICAM1, HTR1A, CDK2, WNT2, POU1F1, ADRA2A, PPARA, IL12A, TIMP3, FOXH1, EBI3, ID2, TRAF3, NOTCH1, SMAD1, IGFBP3, TRAF3IP2, HCFC1, ADRB2, GTF2H1, DDIT3, VAV1, FGF7, MAP3K3, IFI16, NRIP1, PRKCE, MAP3K5, ERBB2, TP73, FGF2, DNM2, ERCC2, LAMA1, GJA1, JUN, LIFR, STAT5A, SMAD3, IL4, MMP9, TCF4, CD28, FGFR1, BCL10, MAPK1, ETS1, HNF4A, CREBBP, REL, NEUROD1, EDA2R, BTC, PPARG, EGFR, PAWR, NR5A1, SMAD4, NOTCH4, CASP3, PPARGC1A, HCLS1, ELA2, ZBTB16, CASP1, FOSL1, ABL1, RB1, SLAMF1, APP, TRAIP, GLI1, MYOG, HIF1A, EP300, CTNNB1, PRKCA, CADM1, TLX1, DLX5, CITED2, PYCARD, SRF, IGF1R, BMPR1A, MYF6, CASP8, E2F1, CAPN1, MYC, GRN, SMAD2, TRAF6, NCOA1, CARD9, TP53, NCK1, HAND1, GATA2, CDK5, HAND2, LCK, FOXO1, DAXX, ZNF423, POU3F2, TGFB1I1, SOX10, CBL, NCOA2, 674 996 15360 2.6999392227664365 6.67754331670676E-20 3.9279666568863294E-21 2.4312979615109708E-20 GOTERM_BP_ALL GO:0042981~regulation of apoptosis 65 9.21% 2.589049760591558E-13 CD28, BCL10, NAIP, IKBKG, MAPK1, CALR, STAT1, PLG, HMGB1, NPM1, PAWR, MAP3K7, SEPT4, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, IL12A, CD74, TIMP3, TRAIP, TRAF3, IGFBP3, CASP5, ADRB2, ACTN2, PRKCA, DDIT3, BCL2L1, CDC2, CADM1, SERPINB2, PYCARD, IGF1R, ACTN3, IFI16, PRKCE, CASP8, MAP3K5, TP73, MIF, DNM2, SFRP1, CASP2, ERCC2, TRAF6, CARD9, TP53, CTSB, TRAF1, HDAC1, CDK5, LCK, DAXX, FOXO1, YWHAZ, STAT5A, SMAD3, WRN, IL4, CRYAA, MAPK8, VCP, MMP9, 674 538 15360 2.7533562044278734 1.3602816650859495E-9 2.6159296950822863E-11 4.952815935155286E-10 GOTERM_BP_ALL GO:0048519~negative regulation of biological process 128 18.13% 3.2351078946236326E-22 RAP1A, CAV3, NFKBIA, BAI1, PTPN6, PER1, BIN1, PLG, MMP14, TAX1BP3, HMGB1, RYBP, CDKN3, PRKCG, MAP3K7, AXIN1, WNT2, POU1F1, ZBTB17, OTUD7B, ARHGDIB, RGS19, ADRBK1, LRP1, ID2, NOTCH1, SMAD1, IGFBP3, ADRB2, DDIT3, RGS2, SERPINB2, ABI1, NRIP1, ORC2L, CTBP1, ERCC4, TP73, FRK, FGF2, CASP2, GJA1, JUN, CDC6, MBD2, HDAC1, STAT5A, FABP4, CAV1, SMAD3, IL4, CRYAA, MAPK8, EPHB2, TCF4, PLEKHO1, CD28, SPTA1, BCL10, NAIP, MAPK1, ETS1, IL27RA, IAPP, SMARCA4, FZD1, PPARG, RHOH, EGFR, NPM1, RND1, PAWR, PMP22, SMAD4, NOTCH4, CBX2, RNF2, CASP3, ELA2, PIK3R1, ZBTB16, CD74, RB1, PTGS2, MDFI, LMO2, ADCYAP1, SERPINA5, CTNNB1, PRKCA, BCL2L1, CDC2, CADM1, CBLC, PYCARD, MDM4, IGF1R, RBL1, TWIST1, MYF6, STAT3, E2F1, NCOR1, MIF, SFRP1, MYC, TIE1, IRF8, CDC45L, IRF2, TP53, ZMYND11, STARD13, ZEB2, SIX3, HAND1, FOXO1, DAXX, YWHAZ, PLAU, ZNF423, MDM2, HIC1, TGFB1I1, RAC1, PLN, WT1, NCOA2, 674 1181 15360 2.469968366595728 1.6997256878352566E-18 9.442920487973649E-20 6.188712530882965E-19 GOTERM_BP_ALL GO:0048518~positive regulation of biological process 127 17.99% 2.90137073182763E-24 KIT, PPP5C, IKBKG, GATA4, FHL2, PLG, FYN, PRKCG, MAP3K7, TICAM1, HTR1A, CDK2, WNT2, POU1F1, ADRA2A, PPARA, IL12A, TIMP3, FOXH1, EBI3, ID2, TRAF3, NOTCH1, SMAD1, TRAF3IP2, IGFBP3, HCFC1, ADRB2, GTF2H1, DDIT3, VAV1, FGF7, MAP3K3, IFI16, NRIP1, PRKCE, MAP3K5, ERBB2, TP73, FGF2, DNM2, ERCC2, LAMA1, GJA1, JUN, LIFR, STAT5A, CAV1, SMAD3, IL4, MMP9, TCF4, CD28, FGFR1, BCL10, MAPK1, ETS1, HNF4A, IL27RA, CREBBP, REL, EDA2R, NEUROD1, BTC, PPARG, EGFR, PAWR, NR5A1, SMAD4, NOTCH4, ACHE, PPARGC1A, CASP3, HSP90AA1, HCLS1, ELA2, ZBTB16, CASP1, FOSL1, ABL1, RB1, SLAMF1, APP, TRAIP, GLI1, MYOG, HIF1A, EP300, CTNNB1, PRKCA, LIMK1, C1QA, CADM1, TLX1, DLX5, CITED2, PYCARD, SRF, IGF1R, BMPR1A, MYF6, CASP8, E2F1, CHRM3, CAPN1, MYC, GRN, SMAD2, TRAF6, NCOA1, CARD9, TP53, NCK1, HAND1, GATA2, CDK5, HAND2, LCK, FOXO1, DAXX, ZNF423, POU3F2, TGFB1I1, SOX10, CR2, CBL, NCOA2, 674 1106 15360 2.6168565311411722 1.5243801825022367E-20 1.0162534550014911E-21 5.55027838009331E-21 GOTERM_BP_ALL GO:0048514~blood vessel morphogenesis 17 2.41% 0.002594057842249635 NOTCH4, TIE1, CTNNB1, FGFR1, CTGF, FGF1, HAND1, CSPG4, HAND2, CASP8, PLG, MMP14, ERBB2, FGF2, KDR, MAP3K7, S100A7, 674 166 15360 2.3338457688320045 0.9999988163266829 0.049466549891458045 4.847413560068903 GOTERM_BP_ALL GO:0048513~organ development 128 18.13% 3.5997570542610457E-19 KIT, CAPN3, KCNJ8, CAV3, GATA4, NFKBIA, PLG, MMP14, COL1A2, FYN, RAG1, MAP3K7, S100A7, LAMA3, ALK, PLCE1, WNT2, POU1F1, PPARA, TTN, KLF1, CEBPE, ADRBK1, FOXH1, ID2, NOTCH1, SMAD1, KRT17, IGFBP3, ADRB2, DDIT3, FGF7, IFI16, CSRP3, NRIP1, ERBB2, TP73, FGF2, MAP3K7IP1, AR, ERCC2, PRKDC, GJA1, RELB, CTGF, ACTB, GJA8, FGF1, STAT5A, PAX3, SGCG, ATP2B2, SMAD3, IL4, MMP9, FGFR1, MAPK1, TAL1, LHX3, DCN, ETS1, EDA2R, NEUROD1, MYF5, SMARCA4, RHOH, EGFR, NR5A1, CRKL, SMAD4, NOTCH4, PPP3R1, ACHE, CASP3, HCLS1, PIK3R1, ZBTB16, CD74, CSPG4, RB1, APP, LRP2, GLI1, MYOG, PTGS2, EP300, CD44, LMO2, EPB42, BMP1, CTNNB1, HOXA5, TLX1, DLX5, CITED2, SRF, IGF1R, BMPR1A, TWIST1, MYF6, CASP8, E2F1, SALL1, PAX5, PKP2, NTRK1, RAG2, SMAD2, PRKG1, TIE1, IRF8, HCK, FGD1, ACTC1, ALPL, HOXD10, SIX3, HAND1, GATA2, CDK5, HAND2, LCK, FOXO1, SIX1, POU3F2, PLN, ASCL1, KDR, 674 1282 15360 2.275376474999653 1.8913123563087533E-15 6.754686986816976E-17 6.886280864654579E-16 GOTERM_BP_ALL GO:0033238~regulation of amine metabolic process 10 1.42% 6.740608436785569E-4 PRKCE, PRKCA, HCLS1, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 674 56 15360 4.069520983467571 0.9710651870322115 0.016267663117032094 1.2816194029098615 GOTERM_BP_ALL GO:0008286~insulin receptor signaling pathway 8 1.13% 8.256926500912214E-4 GAB1, FOXO1, PRKCA, SNF1LK2, PIK3R1, IGF1R, IRS1, SORBS1, 674 36 15360 5.064292779426311 0.9869632263885466 0.01927364079281657 1.5677705322662217 GOTERM_BP_ALL GO:0008285~negative regulation of cell proliferation 27 3.82% 2.2932124267404096E-5 ABI1, BAI1, MDM4, PTPN6, ETS1, PLG, CTBP1, FGF2, FRK, CDKN3, NPM1, PAWR, PMP22, SMAD4, GJA1, WNT2, CASP3, POU1F1, TP53, ZBTB16, CDC6, RB1, MDM2, CAV1, TGFB1I1, PTGS2, SMAD1, 674 242 15360 2.542609804546681 0.11351117776109587 7.574913384407189E-4 0.04385968913194205 GOTERM_BP_ALL GO:0008284~positive regulation of cell proliferation 31 4.39% 2.2569441957637097E-7 CD28, KIT, FGFR1, TLX1, FGF7, IGF1R, BMPR1A, ERBB2, CAPN1, BTC, FGF2, EGFR, MYC, GRN, LAMA1, HTR1A, CDK2, HCLS1, ELA2, ADRA2A, FOSL1, NCK1, LIFR, IL12A, EBI3, SLAMF1, STAT5A, GLI1, POU3F2, IL4, ADRB2, 674 240 15360 2.943620178041543 0.001185095833016847 1.1186716809219455E-5 4.3174913189059083E-4 GOTERM_BP_ALL GO:0008283~cell proliferation 94 13.31% 1.1914903156445895E-18 CD28, KIT, CDC25A, FGFR1, FGF8, TAL1, BAI1, NFKBIA, PTPN6, ETS1, CDC14A, PLG, BIN1, MMP14, TNFRSF14, CDK3, BTC, PDZK1, EGFR, NPM1, CDKN3, PAWR, PMP22, SMAD4, PLCE1, DBP, CDK2, HTR1A, WNT2, ACHE, CASP3, POU1F1, HCLS1, ELA2, ZBTB16, ADRA2A, FOSL1, IL12A, CD74, SLAMF1, EBI3, RB1, LRP1, LRP2, TRAIP, GLI1, RAF1, PTGS2, NOTCH1, SMAD1, ADRB2, FES, CTNNB1, TLX1, CADM1, ABI1, MDM4, FGF7, IGF1R, BMPR1A, IFI16, GAB1, E2F1, CTBP1, ERBB2, CHRM3, CAPN1, FRK, MIF, FGF2, AR, MYC, GRN, LAMA1, GJA1, SETDB1, IRF2, TP53, ZMYND11, NCK1, CDC6, LIFR, FGF1, CSF1R, CDK5, FOXO1, STAT5A, MDM2, CAV1, POU3F2, TGFB1I1, SMAD3, ASCL1, IL4, 674 796 15360 2.6912008111775494 6.260090118396673E-15 1.9562781619989603E-16 2.2793029744416687E-15 GOTERM_BP_ALL GO:0019233~sensory perception of pain 5 0.71% 0.005506908403653599 DLG2, GRM1, TRPV1, IAPP, ADRB2, 674 17 15360 6.702740443358353 0.999999999999749 0.09366838919251452 10.02492167178184 GOTERM_BP_ALL GO:0030902~hindbrain development 6 0.85% 0.004863320902682881 GLI1, SMARCA4, ATP2B2, FGF2, SMAD1, NEUROD1, 674 26 15360 5.259073270942707 0.9999999999924858 0.08425870878832742 8.904479930338994 GOTERM_BP_ALL GO:0048489~synaptic vesicle transport 6 0.85% 0.001802855306874147 SNAP25, CTNNB1, LIN7A, DNM2, NLGN1, SYP, 674 21 15360 6.511233573548115 0.9999236933573094 0.03692310991351522 3.393047551073869 GOTERM_BP_ALL GO:0008219~cell death 100 14.16% 2.561640492900599E-20 IKBKG, GZMB, NFKBIA, PTPN6, STAT1, PLG, TNFRSF14, HMGB1, RYBP, PRKCG, MAP3K7, AXIN1, DFFA, IL12A, ELMO1, TIMP3, AHR, TRAF3, IGFBP3, GZMA, CASP5, ADRB2, DDIT3, SERPINB2, IFI16, ITGB2, PRKCE, MAP3K5, ATG12, TP73, FGF2, DNM2, CASP2, ERCC2, PRKDC, GJA1, AGTR2, E2F2, CTSB, ATG5, HDAC1, STAT5A, PAX3, SMAD3, TNFRSF1B, WRN, GADD45G, IL4, MAPK8, CRYAA, MMP9, CD28, BCL10, NAIP, ATXN2, MAPK1, CALR, IAPP, NPM1, PAWR, SEPT4, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, CD74, APP, TRAIP, EAF2, TBP, RAF1, EP300, ACTN2, SIAH2, BCL2L1, PRKCA, CDC2, CADM1, MDM4, PYCARD, IGF1R, ACTN3, PAK1, CASP8, E2F1, MIF, SFRP1, DFFB, TRAF6, CARD9, TP53, ACTC1, TRAF1, CDK5, LCK, DAXX, FOXO1, YWHAZ, VCP, 674 834 15360 2.7325320752300235 1.3458859149699747E-16 5.851677891173803E-18 4.9003795652000954E-17 GOTERM_BP_ALL GO:0030900~forebrain development 12 1.70% 2.1632470722297623E-5 E2F1, PRKG1, CTNNB1, LRP2, GLI1, POU1F1, SMARCA4, TP73, POU3F2, FYN, ASCL1, GATA2, 674 55 15360 4.972214728891287 0.10743704547539235 7.190972150347141E-4 0.041374475710775904 GOTERM_BP_ALL GO:0019226~transmission of nerve impulse 34 4.82% 2.6394023314463263E-5 CTNNB1, DLGAP2, SLC6A1, MAPK1, LIN7A, PHOX2A, NLGN1, HAP1, GRM1, NOS1, PLP1, MPZ, ERBB2, TH, KCNK3, PNOC, PMP22, SNCB, NRXN2, DLG4, ACHE, WNT2, DLG2, STX1A, KIF5A, APBA1, CACNA1B, SNAP25, GABARAPL2, PARK2, ACCN1, CAMK4, AKAP5, HOMER1, 674 348 15360 2.226542515092602 0.1294899968857598 8.663496810470406E-4 0.05047928914074795 GOTERM_BP_ALL GO:0019222~regulation of metabolic process 203 28.75% 8.328577901146513E-12 MAFK, GATA4, POU2AF1, CRY1, STAT1, UPF1, HMGB1, NRF1, PRKCG, POU1F1, ZBTB17, RFXANK, FOXH1, EBI3, SRY, AHR, ID2, SRPK1, SUB1, GCM1, GTF2H1, DDIT3, MAX, PHOX2A, ITGB2, NRIP1, PRKCE, CARM1, HOXB9, GJA1, RELB, ATF7IP2, E2F2, JUN, ZNF208, MBD2, HOXB7, GTF2F2, PAX3, CAV1, TNFRSF1B, IL4, SREBF2, TCF4, SPTA1, BCL10, KPNA2, HNF4A, REL, EDA2R, SMARCA4, HOXC8, NR5A1, RXRG, CBX2, RNF2, DBP, TCEA2, HSP90AA1, ELA2, ZBTB16, FOSL1, TAF13, RB1, APP, GLI1, EP300, MDFI, DLGAP2, TLX1, DLX5, MDM4, SRF, TWIST1, MYF6, STAT3, SALL1, PCGF2, HOXB2, PAX5, PABPC1, POLR2A, SMAD2, NCOA1, IRF8, SETDB1, IRF2, HOXD10, ZEB2, GATA2, SMAD7, HAND2, FOXO1, DAXX, MDM2, SIX1, POU3F2, TGFB1I1, SOX10, PAX2, WT1, IKBKG, PER1, MEOX1, FHL2, MEOX2, YBX1, RYBP, CIITA, IKBKAP, CDK2, PPARA, KLF1, CEBPE, IL12A, FOS, SP4, CHAF1B, HOXD4, NOTCH1, SMAD1, IGFBP3, HCFC1, EYA1, CREB3, ADRB2, RFX1, ASCC2, IFI16, SAFB, ORC2L, TP73, FGF2, DNM2, AR, ERCC2, CCNT1, CDC6, REN, HDAC1, CRK, STAT5A, DACH1, FABP4, SMAD3, CD28, RUNX1T1, LHX3, TAL1, CALR, ETS1, CREBBP, NEUROD1, ANKRD1, MYF5, FZD1, RHOH, PPARG, TRIP4, EGFR, NPM1, HEYL, PAWR, SMAD4, NOTCH4, TAF1, PPARGC1A, HCLS1, ZBTB33, ABL1, CHD1, CHAF1A, HOXA9, EAF2, MYOG, TBP, HIF1A, CAMK2A, NHLH1, MYT1, SERPINA5, CTNNB1, HOXA5, PRKCA, CITED2, PYCARD, RBL1, E2F1, NCOR1, NFE2, MYC, MIZF, CDC45L, MEIS1, TP53, ZMYND11, NCK1, HAND1, SIX3, ZNF423, HIC1, ASCL1, NCOA2, 674 2975 15360 1.5550357828591377 4.375825357616492E-8 7.416652847425098E-10 1.5932410946106756E-8 GOTERM_BP_ALL GO:0019220~regulation of phosphate metabolic process 11 1.56% 0.0020822729517433916 PRKCE, BCL10, PRKCA, HCLS1, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 674 78 15360 3.2138781100205436 0.9999824712511047 0.041402915162813025 3.909054772196663 GOTERM_BP_ALL GO:0002250~adaptive immune response 12 1.70% 7.022187550893254E-4 EBI3, TRAF6, BCL10, C1QA, RELB, CADM1, IL4, CR2, MAP3K7, IL12A, IL27RA, CD74, 674 80 15360 3.41839762611276 0.9750468035076889 0.01678755310468616 1.3348169878054872 GOTERM_BP_ALL GO:0019219~regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 185 26.20% 2.1020793945880027E-11 MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, HMGB1, NRF1, RYBP, PRKCG, CIITA, IKBKAP, CDK2, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, SRPK1, NOTCH1, SMAD1, HCFC1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, ASCC2, SAFB, IFI16, NRIP1, ORC2L, TP73, DNM2, AR, CARM1, ERCC2, HOXB9, CCNT1, RELB, E2F2, ATF7IP2, JUN, CDC6, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PAX3, DACH1, FABP4, SMAD3, TNFRSF1B, IL4, SREBF2, TCF4, RUNX1T1, KPNA2, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, EDA2R, NEUROD1, MYF5, SMARCA4, FZD1, PPARG, RHOH, TRIP4, HOXC8, NPM1, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, TCEA2, PPARGC1A, HCLS1, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, CAMK2A, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, PYCARD, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, PABPC1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, CDC45L, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, ASCL1, PAX2, SOX10, WT1, NCOA2, 674 2658 15360 1.5861639348654641 1.1044296555073885E-7 1.781338299089441E-9 4.0212355667534894E-8 GOTERM_BP_ALL GO:0048469~cell maturation 15 2.12% 3.466742422839797E-7 EPB42, CTNNB1, FGFR1, ACTC1, NLGN1, PLP1, KLF1, TTN, REN, ACTB, GATA2, APP, PICK1, RND1, SOX10, 674 62 15360 5.5135445582463865 0.0018197689937351491 1.702253534707765E-5 6.631805043677552E-4 GOTERM_BP_ALL GO:0048468~cell development 142 20.11% 5.264737955924606E-27 IKBKG, GZMB, NFKBIA, BAI1, PTPN6, STAT1, PLG, TNFRSF14, MMP14, HMGB1, FYN, RYBP, PRM1, PRKCG, RAG1, MAP3K7, AXIN1, WNT2, DFFA, TTN, KLF1, IL12A, ELMO1, TIMP3, AHR, TRAF3, BRSK2, NOTCH1, GZMA, IGFBP3, CASP5, GCM1, ADRB2, DDIT3, SERPINB2, NLGN1, PLP1, IFI16, ITGB2, PRKCE, MAP3K5, ATG12, TP73, FGF2, PTPN11, DNM2, CASP2, ERCC2, PRKDC, GJA1, AGTR2, E2F2, CTSB, ATG5, REN, ACTB, PTPRZ1, HDAC1, STAT5A, PICK1, PAX3, ATP2B2, SMAD3, TNFRSF1B, WRN, GADD45G, IL4, CRYAA, MAPK8, S100A4, MMP9, CD28, FGFR1, BCL10, NAIP, ATXN2, MAPK1, CALR, IAPP, SMARCA4, HOXC8, NPM1, RND1, PAWR, PPP3R1, SEPT4, ACHE, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, CD74, APP, EAF2, TRAIP, TBP, RAF1, EP300, ACTN2, EPB42, CTNNB1, SIAH2, PRKCA, BCL2L1, LIMK1, CDC2, CADM1, TLX1, DLX5, PYCARD, MDM4, IGF1R, ACTN3, PARD6B, TWIST1, PAK1, CASP8, E2F1, MIF, SFRP1, DFFB, PRKG1, TRAF6, CARD9, TP53, ACTC1, TRAF1, ZEB2, GATA2, CDK5, LCK, FOXO1, DAXX, YWHAZ, SIX1, POU3F2, ASCL1, PAX2, SOX10, PARD3, VCP, 674 1245 15360 2.599263522934468 2.766093322042788E-23 2.30507776836899E-24 1.0071364177310169E-23 GOTERM_BP_ALL GO:0002237~response to molecule of bacterial origin 4 0.57% 0.005768964486061542 BCL10, MAPK1, NFKBIA, IL12A, 674 9 15360 10.128585558852622 0.9999999999999372 0.09545490824924419 10.477391038905637 GOTERM_BP_ALL GO:0045786~negative regulation of progression through cell cycle 23 3.26% 1.2985645604199423E-4 AXIN1, BCL10, RAP1A, DDIT3, CASP3, TP53, CADM1, ZBTB17, ZMYND11, STARD13, PYCARD, RBL1, RB1, BIN1, HIC1, TP73, EGFR, CDKN3, WT1, EPHB2, MYC, ADCYAP1, PLEKHO1, 674 209 15360 2.5079153237828855 0.49455200400861765 0.003847439014696752 0.24812123828467092 GOTERM_BP_ALL GO:0008152~metabolic process 445 63.03% 4.140836740949324E-4 KIT, PPP5C, SLC2A2, CAPN3, PTPN6, CRY1, MMP14, CDK3, HMGB1, NRF1, FYN, PPP1R3A, RAG1, PRKCG, ATG7, PLCE1, PRKD3, CHKA, RFXANK, DFFA, RCC1, CA8, SLC34A1, AHR, ID2, MAP3K14, SUB1, GCM1, CLTCL1, GTF2H1, MAX, DDIT3, ABI1, ITGB2, NRIP1, PRKCE, CSNK1A1, MAP3K5, CTBP1, PPEF2, CARM1, PTPRT, PRKDC, HOXB9, RELB, ATF7IP2, E2F2, CTSB, JUN, PTPRZ1, NDOR1, HOXB7, PICK1, PAX3, CAV1, ATP2B2, MMP3, MMP9, FGFR4, CDC25A, ASIP, BCL10, INPPL1, HNF4A, IL27RA, REL, EDA2R, SMARCA4, U2AF2, NR5A1, SNCB, CBX2, RNF2, ANAPC10, HSP90AA1, ELA2, FOSL1, TAF13, RB1, NCF2, EP300, EPB42, DLGAP2, LIPE, DLX5, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, CAPN1, TH, INSIG2, MIF, PTPRN, GRN, PRKG1, SETDB1, IRF8, IRF2, HOXD10, ZEB2, GATA2, FOXO1, DAXX, MAP3K8, TGFB1I1, XAB2, MICAL1, CBL, IKBKG, CAV3, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, NEK2, RYBP, CTSS, CDKN3, MAP3K7, ATP7B, CIITA, ALK, NUAK1, CPNE1, CEBPE, DAG1, UBE2I, FOS, NOTCH1, SMAD1, IGFBP3, DUSP6, EYA1, PTPRH, ASCC2, PLP1, IFI16, SAFB, ORC2L, ERCC4, FGF2, AXL, AR, CASP2, ERCC2, EPHA3, CTSF, VCPIP1, CDC6, TUBA1A, HDAC1, DACH1, SMAD3, KIFAP3, MAPK8, GNA14, EPHB2, LIN7A, LHX3, CALR, NEUROD1, FZD1, RHOH, EGFR, ACHE, CASP3, PPARGC1A, ROS1, PIK3R1, MYOG, SI, TBP, HIF1A, CAMK2A, NEDD4, LIMK1, CBLC, CITED2, RBL1, PSMB9, PAK1, E2F1, NCOR1, MIZF, RAG2, TIE1, TRAF6, CDC45L, PLA2G2A, APBA1, SIX3, HAND1, DDC, LCK, PLAU, PLCG1, ZNF423, RAD52, PARD3, NCOA2, MAFK, TUBA3C, GATA4, GZMB, POU2AF1, PLCD1, STAT1, UPF1, MAP2K7, PPEF1, PRM1, PLAT, POU1F1, DOCK2, ZBTB17, SLC9A3R1, OTUD7B, ADRBK1, FOXH1, EBI3, SRY, SRPK1, CASP5, USP2, PHOX2A, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, DNMT3A, PTPN11, PPFIBP2, GLS2, EXOSC4, GJA1, RFXAP, ZNF208, MBD2, CUBN, GTF2F2, TNFRSF1B, WRN, GADD45G, IL4, SLC9A3R2, SREBF2, ABP1, TCF4, SPTA1, KPNA2, GPHN, GSK3A, ABCB4, MAPK1, DDX5, HOXC8, USP9X, CRKL, RXRG, MPP6, DBP, TCEA2, EPHB1, ZBTB16, CD74, APP, GLI1, MOS, SCG5, PTGS2, RAF1, MDFI, MAGI1, ACP1, ACTN2, BMP1, SIAH2, CDC2, C1QA, HK3, TLX1, MMP7, SRF, PRKAR2A, NSF, ACTN3, MYF6, PEX6, CASP8, FGR, PCSK1, SALL1, CHRM3, PCGF2, PLA2G7, HOXB2, PAX5, PABPC1, DFFB, CBX1, FER, NTRK1, BLK, POLR2A, SMAD2, NCOA1, CTSG, HCK, TRAF1, PRKAB1, CDK5, SMAD7, HAND2, MDM2, FANCA, SIX1, POU3F2, RAC1, SOX10, PAX2, WT1, DYRK1A, NOS1, PER1, MEOX1, FHL2, MEOX2, YBX1, PARP1, PCSK2, DLG4, IKBKAP, AXIN1, CDK2, WNT2, PTK2, PPARA, KLF1, TTN, IL12A, LRP1, PXN, PARK2, SP4, CHAF1B, HOXD4, SNF1LK2, BRSK2, CAMK4, GZMA, PRKACA, HCFC1, CREB3, ADRB2, RFX1, CASK, NMI, TJP1, ERBB2, ATG12, TP73, FRK, DNM2, MAPK14, TTR, EXOSC1, CCNT1, REN, CTGF, CRK, IREB2, STAT5A, FABP4, CRYAA, PLD1, CD28, RUNX1T1, FGFR1, TAL1, MARK1, TG, ETS1, CREBBP, ANKRD1, ATOX1, MYF5, PDE4DIP, PPARG, TRIP4, NPM1, PAWR, HEYL, SMAD4, NOTCH4, TAF1, APC2, MAP3K4, HCLS1, ZBTB33, CASP1, CHD1, ABL1, CHAF1A, HOXA9, LRP2, EAF2, MME, LNPEP, NHLH1, MYT1, FES, SERPINA5, CTNNB1, HOXA5, PRKCA, PFTK1, TEC, PYCARD, PARD6B, STAMBPL1, PPP1CA, NFE2, STX12, WIPF1, MYC, PTPRS, PDE4D, MEIS1, TP53, ZMYND11, ALPL, NCK1, CSF1R, HIC1, COPS5, ASCL1, KDR, CR2, VCP, NTRK2, 674 9181 15360 1.1045905991505485 0.8865106395966424 0.010662190896509216 0.7891694412132333 GOTERM_BP_ALL GO:0032989~cellular structure morphogenesis 42 5.95% 8.315072384032248E-5 SPTA1, ACTN2, EPB42, CTNNB1, FGFR1, LIMK1, DLX5, BAI1, NOV, PARD6B, ITGB2, IGFBP5, CAP1, DDX5, TP73, FYN, WNT1, PTPN11, AR, GNA12, SMAD4, PLCE1, PRKG1, GJA1, FGD1, TP53, NCK1, CTGF, AKAP2, PTPRZ1, CDK5, RB1, RAC3, ATP2B2, POU3F2, RAC1, SMAD3, BRSK2, PAX2, IGFBP3, PARD3, NEDD9, 674 499 15360 1.9181389485201858 0.3539588433566896 0.002551663328472231 0.15894623862988677 GOTERM_BP_ALL GO:0008016~regulation of heart contraction 13 1.84% 4.483408331847602E-7 PRKCA, ACTC1, TNNT2, SLC8A1, CSRP3, CACNA1B, ADRBK1, SCN5A, S100A1, SP4, PLN, KCNJ12, ADRB2, 674 46 15360 6.440459295574764 0.0023528110567671012 2.1414164039668115E-5 8.576657553605038E-4 GOTERM_BP_ALL GO:0008015~blood circulation 23 3.26% 3.879934107823468E-6 WNT2, AGTR2, KCNJ8, PRKCA, ACTC1, TNNT2, REN, SLC8A1, CSRP3, MEOX2, CACNA1B, ADRBK1, SCN5A, S100A1, SP4, CAV1, HOXB2, NFE2, PTGS2, PLN, NTS, KCNJ12, ADRB2, 674 167 15360 3.138648518985767 0.02017883959062472 1.5560020867222413E-4 0.007421994290846001 GOTERM_BP_ALL GO:0051347~positive regulation of transferase activity 25 3.54% 1.01827131492814E-8 KIT, IKBKG, GRM1, GAB1, MAP3K5, ERBB2, FGF2, PTPN11, EGFR, MAP3K7IP1, MAP3K7, PLCE1, TRAF6, PRKD3, MAP3K4, ELA2, ADRA2A, DAXX, PICK1, GADD45G, GNB2L1, PARD3, MDFI, IRS1, ADRB2, 674 141 15360 4.040659132520992 5.3498543891694617E-5 5.879116402596196E-7 1.947937456892035E-5 GOTERM_BP_ALL GO:0007626~locomotory behavior 25 3.54% 6.232343159695747E-6 CXCL2, OPRD1, MAPK1, PRKCA, CCR3, GRM1, SERPIND1, ITGB2, RALA, FGF2, FER, MAPK14, IL16, DEFB1, CCL8, DOCK2, ELA2, CCR1, FOSL1, CACNA1B, PLAU, TRH, IL4, CREB3, PLD1, 674 198 15360 2.8774390792194944 0.03221452499784638 2.3898481813611205E-4 0.011921704775441633 GOTERM_BP_ALL GO:0051338~regulation of transferase activity 40 5.67% 1.2815342497949446E-12 CDC25A, KIT, GTF2H1, CDK5R2, PRKCA, IKBKG, CAV3, GRM1, RBL1, GAB1, MAP3K5, ERBB2, PTPN11, FGF2, MAP3K7IP1, EGFR, CDKN3, MAP3K7, PLCE1, TRAF6, CCNT1, CASP3, MAP3K4, PRKD3, ELA2, ADRA2A, CDC6, RB1, DAXX, PICK1, FABP4, CAV1, GADD45G, C13orf15, GNB2L1, PARD3, MDFI, DUSP6, IRS1, ADRB2, 674 241 15360 3.7824593373308546 6.733160917704595E-9 1.1812562039636987E-10 2.4515500740562857E-9 GOTERM_BP_ALL GO:0002026~regulation of the force of heart contraction 5 0.71% 2.2202195965804488E-4 ADRBK1, PRKCA, PLN, SLC8A1, CSRP3, 674 8 15360 14.2433234421365 0.6885862577126021 0.00615364906024185 0.42387093146072363 GOTERM_BP_ALL GO:0051329~interphase of mitotic cell cycle 14 1.98% 1.7929959258358572E-4 TAF1, KPNA2, CDK2, ANAPC10, CDC2, ABL1, CDC6, RCC1, RB1, E2F1, GSPT2, MDM2, DNM2, CDKN3, 674 92 15360 3.4679396206941036 0.6102011816071888 0.00513499205875334 0.3424404958647598 GOTERM_BP_ALL GO:0032944~regulation of mononuclear cell proliferation 8 1.13% 0.004103318906301223 CD28, EBI3, STAT5A, ERBB2, CASP3, IL4, NCK1, IL12A, 674 47 15360 3.8790327672201528 0.9999999995851857 0.07425295487150196 7.564340781526857 GOTERM_BP_ALL GO:0032943~mononuclear cell proliferation 10 1.42% 0.003362023688914717 CD28, EBI3, STAT5A, ERBB2, TNFRSF14, CASP3, CADM1, IL4, NCK1, IL12A, 674 70 15360 3.255616786774057 0.9999999793144966 0.06275688934389234 6.239203256175152 GOTERM_BP_ALL GO:0007610~behavior 37 5.24% 3.8164853603549403E-7 CXCL2, OPRD1, PRKCA, MAPK1, CCR3, GRM1, SERPIND1, ITGB2, RALA, MPZ, FYN, FGF2, MAPK14, FER, PRKCG, PMP22, IL16, DEFB1, DLG4, CCL8, HTR1A, AGTR2, DOCK2, ELA2, CCR1, FOSL1, REN, MBD2, CACNA1B, APP, PARK2, PLAU, TRH, IL4, TRPV1, PLD1, CREB3, 674 328 15360 2.5707461822392705 0.0020031727568060598 1.8395994009656746E-5 7.3008535812491E-4 GOTERM_BP_ALL GO:0051325~interphase 14 1.98% 3.393400134988674E-4 TAF1, KPNA2, CDK2, ANAPC10, CDC2, ABL1, CDC6, RCC1, RB1, E2F1, GSPT2, MDM2, DNM2, CDKN3, 674 98 15360 3.255616786774057 0.8318997922582174 0.008920750779246589 0.6471593313929214 GOTERM_BP_ALL GO:0002009~morphogenesis of an epithelium 12 1.70% 0.0010629776559255536 CASP8, DAG1, CTNNB1, STAT5A, BCL10, SIX1, FZD1, PPARG, JUN, F11R, MAP3K7, ZEB2, 674 84 15360 3.2556167867740573 0.9962569519512414 0.024105813184712055 2.0139845761394493 GOTERM_BP_ALL GO:0051318~G1 phase 7 0.99% 3.682783938845147E-4 RB1, TAF1, E2F1, CDK2, MDM2, CDC2, CDC6, 674 23 15360 6.935879241388207 0.8556177620953296 0.00958210995682962 0.7021639918425859 GOTERM_BP_ALL GO:0051301~cell division 21 2.97% 0.005677209484343519 CDC25A, SEPT4, CDK2, ANAPC10, CCNT1, CDC2, CDC6, RCC1, PARD6B, CDK5, CDC14A, ROPN1B, RB1, DAXX, UBE2I, CDK3, PPP1CA, NEK2, NOTCH1, PARD3, NEDD9, 674 245 15360 1.9533700720644342 0.999999999999898 0.09520207477379661 10.319211588014877 GOTERM_BP_ALL GO:0007568~aging 6 0.85% 0.004072454072612692 CP, DDIT3, PHOX2A, TP53, WRN, NPM1, 674 25 15360 5.4694362017804155 0.9999999995118317 0.07422457941571037 7.509522836046245 GOTERM_BP_ALL GO:0045638~negative regulation of myeloid cell differentiation 6 0.85% 0.0011078647330951315 CTNNB1, STAT5A, ZBTB16, NFKBIA, IL4, LMO2, 674 19 15360 7.196626581290021 0.9970440877950788 0.024790758203864338 2.0981787352576275 GOTERM_BP_ALL GO:0045637~regulation of myeloid cell differentiation 9 1.27% 1.9815475641674868E-4 RB1, CTNNB1, STAT5A, ID2, ZBTB16, NFKBIA, IL4, ETS1, LMO2, 674 38 15360 5.397469935967515 0.6469721231091209 0.005552486224930986 0.3783869231783754 GOTERM_BP_ALL GO:0018212~peptidyl-tyrosine modification 14 1.98% 1.2270953783477301E-6 KIT, DYRK1A, PRKCA, HCLS1, ABI1, ABL1, IL12A, ITGB2, PRKCE, STAT1, TNFRSF14, FYN, EGFR, IL4, 674 59 15360 5.407634662777247 0.006426424709237044 5.328091996992246E-5 0.0023473888100977724 GOTERM_BP_ALL GO:0042592~homeostatic process 42 5.95% 1.19826788813269E-6 CTNNB1, BCL10, PRKCA, IKBKG, DDIT3, BCL2L1, CAV3, CCR3, SRF, CALR, KCNA5, CREBBP, SLC9A1, IAPP, CSRP3, ATOX1, PLG, ATP7B, MYC, PLCE1, CP, OPRL1, PPARGC1A, CASP3, SLC9A3, ELA2, SLC9A3R1, CCR1, IREB2, LCK, APP, CUBN, STAT5A, FABP4, ATP2B2, CAV1, HIF1A, PLN, SMAD1, TRPV1, EP300, ADRB2, 674 418 15360 2.289835730410461 0.006275926840405455 5.2462817580201104E-5 0.0022922434693040117 GOTERM_BP_ALL GO:0030522~intracellular receptor-mediated signaling pathway 9 1.27% 0.002277032469574923 RB1, DAXX, CTNNB1, NCOA1, PPARGC1A, TGFB1I1, FHL2, NCOA2, NRIP1, 674 54 15360 3.7982195845697326 0.9999937139016795 0.0446852285832825 4.267175779571664 GOTERM_BP_ALL GO:0030521~androgen receptor signaling pathway 8 1.13% 4.736216743274927E-4 RB1, DAXX, CTNNB1, NCOA1, PPARGC1A, TGFB1I1, FHL2, NRIP1, 674 33 15360 5.5246830321014295 0.917006894848062 0.012009812857604607 0.9021517039303761 GOTERM_BP_ALL GO:0030518~steroid hormone receptor signaling pathway 9 1.27% 0.0013697867646357248 RB1, DAXX, CTNNB1, NCOA1, PPARGC1A, TGFB1I1, FHL2, NCOA2, NRIP1, 674 50 15360 4.102077151335311 0.9992547518060133 0.029321023164449733 2.588097164566394 GOTERM_BP_ALL GO:0001944~vasculature development 19 2.69% 0.0018610287490142968 NOTCH4, TIE1, CTNNB1, FGFR1, CTGF, FGF1, HAND1, CSPG4, HAND2, CASP8, FOXO1, PLG, ERBB2, MMP14, FGF2, KDR, MAP3K7, CRKL, S100A7, 674 191 15360 2.267000170895024 0.9999438202831727 0.03765302724982145 3.500693810549438 GOTERM_BP_ALL GO:0018193~peptidyl-amino acid modification 16 2.27% 3.4124884811059125E-4 KIT, DYRK1A, PRKCA, HCLS1, ABI1, ABL1, IL12A, CREBBP, ITGB2, PRKCE, STAT1, TNFRSF14, FYN, EGFR, IL4, EP300, 674 124 15360 2.940557097731406 0.8335778146025088 0.008926061225921877 0.6507884403870068 GOTERM_BP_ALL GO:0006521~regulation of amino acid metabolic process 10 1.42% 6.740608436785569E-4 PRKCE, PRKCA, HCLS1, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 674 56 15360 4.069520983467571 0.9710651870322115 0.016267663117032094 1.2816194029098615 GOTERM_BP_ALL GO:0051251~positive regulation of lymphocyte activation 10 1.42% 7.698960339479374E-4 CD28, EBI3, LCK, STAT5A, TRAF6, BCL10, IL4, NCK1, MAP3K7, IL12A, 674 57 15360 3.998125878494456 0.9825181431934878 0.018143753304190602 1.4625657881618404 GOTERM_BP_ALL GO:0001932~regulation of protein amino acid phosphorylation 10 1.42% 5.881907177087059E-4 PRKCE, PRKCA, HCLS1, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 674 55 15360 4.143512274076072 0.9545554894742371 0.01447563618466674 1.1192206004814964 GOTERM_BP_ALL GO:0045597~positive regulation of cell differentiation 8 1.13% 0.004626378841856215 RB1, CTNNB1, ID2, PPARG, FGF2, DLX5, IGFBP3, ETS1, 674 48 15360 3.798219584569733 0.999999999973751 0.08138656210810402 8.488659701007261 GOTERM_BP_ALL GO:0051249~regulation of lymphocyte activation 13 1.84% 2.532776581362396E-4 CD28, BCL10, TRAF6, CASP3, NCK1, IL27RA, IL12A, LCK, EBI3, STAT5A, ERBB2, IL4, MAP3K7, 674 83 15360 3.5694111758607128 0.7357578510157126 0.00694378687434638 0.48340551918419905 GOTERM_BP_ALL GO:0045596~negative regulation of cell differentiation 11 1.56% 0.0013900965105938846 NOTCH4, CTNNB1, STAT5A, MAPK1, ZBTB16, NOTCH1, NFKBIA, IL4, LMO2, TWIST1, IAPP, 674 74 15360 3.387601251102735 0.9993302781677341 0.029390657691592326 2.625988795012746 GOTERM_BP_ALL GO:0007519~skeletal muscle development 15 2.12% 7.445433298798583E-6 ACTC1, TTN, ACTB, MYF6, CSRP3, CDK5, APP, PLG, MYOG, MYF5, SIX1, NOTCH1, IGFBP3, EP300, ADRB2, 674 79 15360 4.32708560267438 0.03836320557382111 2.7161902278105554E-4 0.014242040173340076 GOTERM_BP_ALL GO:0045595~regulation of cell differentiation 22 3.12% 6.153501311231922E-6 NOTCH4, CTNNB1, MAPK1, DLX5, NLGN1, NFKBIA, ZBTB16, ETS1, TWIST1, IAPP, RB1, STAT5A, ID2, SIX1, POU3F2, PPARG, FGF2, NOTCH1, ASCL1, IL4, IGFBP3, LMO2, 674 159 15360 3.1532389003975143 0.03181354878581788 2.3769671156181893E-4 0.011770898443563826 GOTERM_BP_ALL GO:0051247~positive regulation of protein metabolic process 12 1.70% 0.002447629626091058 CD28, EBI3, STAT5A, GJA1, BCL10, PPARGC1A, HCLS1, ELA2, IL4, NCK1, IL12A, REL, 674 93 15360 2.940557097731406 0.9999974402727637 0.04777763183207939 4.579827784514623 GOTERM_BP_ALL GO:0007517~muscle development 25 3.54% 8.394928104162554E-7 CAPN3, CAV3, SRF, TWIST1, MYF6, CSRP3, PLG, MYF5, FGF2, ACHE, ACTC1, TTN, ACTB, CDK5, RB1, APP, MYOG, SGCG, SIX1, SMAD3, NOTCH1, PLN, IGFBP3, EP300, ADRB2, 674 177 15360 3.2188301564150277 0.004400984238126626 3.7697555045568265E-5 0.0016059248433286655 GOTERM_BP_ALL GO:0051240~positive regulation of multicellular organismal process 13 1.84% 0.0024994883908513246 BCL10, TRAF6, IKBKG, C1QA, IL27RA, IL12A, LCK, CHRM3, CAV1, FYN, MAP3K7, CR2, ADRB2, 674 107 15360 2.76879558501345 0.9999980520858711 0.04858590173186328 4.674676958072899 GOTERM_BP_ALL GO:0018108~peptidyl-tyrosine phosphorylation 14 1.98% 8.047829817107251E-7 KIT, DYRK1A, PRKCA, HCLS1, ABI1, ABL1, IL12A, ITGB2, PRKCE, STAT1, TNFRSF14, FYN, EGFR, IL4, 674 57 15360 5.597376229892238 0.004219404679981054 3.645046917666317E-5 0.001539526455107687 GOTERM_BP_ALL GO:0051239~regulation of multicellular organismal process 41 5.81% 1.3726905625736324E-10 CD28, BCL10, PRKCA, IKBKG, C1QA, GRM1, SLC8A1, IL27RA, IAPP, CSRP3, SCN5A, ERBB2, CHRM3, FYN, MIF, KCNJ12, MAP3K7, PLCE1, PRKG1, TRAF6, ACHE, CASP3, ACTC1, TNNT2, NCK1, IL12A, CD74, LCK, CACNA1B, ADRBK1, EBI3, S100A1, STAT5A, PARK2, SP4, CAV1, SMAD3, PLN, IL4, CR2, ADRB2, 674 292 15360 3.19986992398683 7.21211512511033E-7 1.0764354740899762E-8 2.6259368013370477E-7 GOTERM_BP_ALL GO:0032774~RNA biosynthetic process 173 24.50% 1.555217424478794E-10 MAFK, IKBKG, GATA4, POU2AF1, PER1, FHL2, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, HMGB1, NRF1, RYBP, CIITA, IKBKAP, POU1F1, ZBTB17, PPARA, RFXANK, KLF1, CEBPE, FOXH1, SRY, FOS, ID2, AHR, HOXD4, CHAF1B, SP4, NOTCH1, SMAD1, HCFC1, SUB1, CREB3, EYA1, GCM1, ADRB2, GTF2H1, RFX1, MAX, DDIT3, PHOX2A, NMI, ASCC2, SAFB, IFI16, NRIP1, ORC2L, TP73, AR, CARM1, ERCC2, HOXB9, CCNT1, RELB, RFXAP, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, CRK, HOXB7, STAT5A, GTF2F2, PAX3, DACH1, SMAD3, IL4, SREBF2, TCF4, RUNX1T1, BCL10, TAL1, LHX3, ETS1, HNF4A, CALR, CREBBP, REL, ANKRD1, NEUROD1, MYF5, SMARCA4, PPARG, TRIP4, HOXC8, PAWR, HEYL, NR5A1, RXRG, SMAD4, NOTCH4, RNF2, CBX2, TAF1, DBP, TCEA2, PPARGC1A, HCLS1, ZBTB33, ZBTB16, FOSL1, CHD1, ABL1, TAF13, CHAF1A, RB1, HOXA9, APP, EAF2, GLI1, MYOG, TBP, HIF1A, NHLH1, MYT1, EP300, MDFI, CTNNB1, DLGAP2, HOXA5, TLX1, DLX5, CITED2, MDM4, SRF, RBL1, MYF6, TWIST1, STAT3, E2F1, SALL1, PCGF2, PAX5, HOXB2, NCOR1, NFE2, MYC, POLR2A, MIZF, SMAD2, NCOA1, SETDB1, IRF8, IRF2, MEIS1, TP53, ZMYND11, HOXD10, ZEB2, SIX3, HAND1, GATA2, HAND2, SMAD7, FOXO1, DAXX, MDM2, ZNF423, SIX1, HIC1, POU3F2, TGFB1I1, COPS5, ASCL1, PAX2, SOX10, WT1, NCOA2, 674 2490 15360 1.5833541882664186 8.171107128696065E-7 1.1842189007182924E-8 2.9751067165406653E-7 GOTERM_BP_ALL GO:0007507~heart development 24 3.40% 7.086026992125532E-9 PPP3R1, CTNNB1, GJA1, CASP3, GATA4, CITED2, SRF, BMPR1A, HAND1, HAND2, CSRP3, CASP8, FOXH1, ADRBK1, ERBB2, ID2, PKP2, MAP3K7IP1, PLN, NOTCH1, CRKL, EP300, PLCE1, PRKDC, 674 128 15360 4.27299703264095 3.722929289640131E-5 4.136664246701116E-7 1.3555461708669725E-5 GOTERM_BP_ALL GO:0009987~cellular process 630 89.24% 2.630079848933287E-13 KIT, CXCL2, PPP5C, CAPN3, HAP1, NFKBIA, BAI1, PTPN6, CRY1, SNX5, MMP14, FHOD1, CDK3, STXBP1, HMGB1, PPP1R3A, FYN, NRF1, RAG1, PRKCG, ATG7, DEFB1, TICAM1, PLCE1, EXOC2, PRKD3, RFXANK, DFFA, ARRB2, RCC1, CA8, IL4R, SLC34A1, ID2, AHR, MAP3K14, C13orf15, NTS, SUB1, GCM1, CLTCL1, GTF2H1, MAX, DDIT3, VAV1, RGS2, ABI1, RPGR, NRIP1, ITGB2, PRKCE, MAP3K5, CSNK1A1, MPZ, CTBP1, TRPV6, PPEF2, RASIP1, PTPRT, CARM1, PRKDC, HOXB9, FCGR2B, CP, RELB, IRS4, E2F2, ATF7IP2, JUN, CTSB, ARRB1, PTPRZ1, FGF1, HOXB7, PICK1, PAX3, CAV1, ATP2B2, MMP3, MMP9, FGFR4, CDC25A, ASIP, BCL10, INPPL1, HNF4A, INADL, IL27RA, REL, EDA2R, IGFBP5, SH2D1A, BTC, SMARCA4, U2AF2, NR5A1, PMP22, SNCB, RNF2, CBX2, ANAPC10, EPB41L3, HSP90AA1, ELA2, FOSL1, TAF13, AKAP2, RB1, NCF2, EP300, EPB42, VIPR2, DLGAP2, LCP2, SLC6A1, CADM1, LIPE, DLX5, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, EFNA2, TH, CAPN1, INSIG2, MIF, PKP2, GRN, PTPRN, PRKG1, OPRL1, SETDB1, IRF8, IRF2, ACTC1, HOXD10, ZEB2, GATA2, SHANK1, FOXO1, DAXX, ATG16L1, ARF1, MAP3K8, TGFB1I1, AKAP13, F11R, XAB2, AKAP5, MICAL1, CBL, PEX26, IKBKG, CAV3, SRC, CABP2, LMNA, UBE2O, CDC14A, SNX17, BIN1, PLG, TNFRSF14, WNT1, AKAP8, KCNK3, NEK2, RYBP, CTSS, CDKN3, MAP3K7, ATP7B, CIITA, ALK, NUAK1, CCL8, HTR1A, SNX19, GNAI3, CEBPE, DAG1, UBE2I, S100A10, FOS, NOTCH1, SMAD1, IGFBP3, DUSP6, EYA1, HSPG2, PTPRH, AKAP3, ASCC2, PLP1, SAFB, IFI16, CSRP3, ORC2L, ERCC4, FGF2, AXL, PNOC, SYNPO, AR, CASP2, IL16, ERCC2, EPHA3, ARHGEF9, CTSF, VCPIP1, ATG5, CDC6, GJA8, HDAC1, TUBA1A, DYNLL1, DACH1, SMAD3, SELE, KIFAP3, GNA14, MAPK8, EPHB2, S100A4, LIN7A, LHX3, CALR, NEUROD1, FZD1, RHOH, EGFR, SEPT4, ACHE, PPARGC1A, CASP3, ROS1, PIK3R1, DCX, CSPG4, TRAIP, MYOG, TBP, HIF1A, CAMK2A, NEDD4, BCL2L1, LIMK1, CBLC, CITED2, CCR3, KISS1, RBL1, PSMB9, PAK1, ITPR1, E2F1, NCOR1, MIZF, RAG2, TIE1, TRAF6, CDC45L, STARD13, PLA2G2A, APBA1, SIX3, HAND1, DDC, LCK, PLAU, PLCG1, ZNF423, DSG2, RAD52, PARD3, NCOA2, MAFK, CDK5R2, TUBA3C, FGF8, GATA4, GZMB, POU2AF1, PLCD1, STAT1, CAP1, RALA, UPF1, MAP2K7, PPEF1, COL1A2, PRM1, PLAT, S100A7, POU1F1, DOCK2, ZBTB17, SLC9A3R1, ADRA2A, OTUD7B, TIMP3, CACNA1B, ADRBK1, FOXH1, EBI3, SRY, SRPK1, GNB2L1, CASP5, USP2, NEDD9, MS4A3, PHOX2A, SERPINB2, NLGN1, GRM1, PTPRG, MAP3K3, HIST3H3, GAB1, GSPT2, CSNK2A1, DNMT3A, PTPN11, CLSTN3, PPFIBP2, GLS2, EXOSC4, LAMA1, GJA1, AGTR2, DLG2, RFXAP, GPR37, ZNF208, MBD2, CUBN, GTF2F2, ACCN1, TNFRSF1B, WRN, GADD45G, IL4, SLC9A3R2, SREBF2, ABP1, TCF4, PLEKHO1, SPTA1, DSC1, KPNA2, GPHN, GSK3A, MAPK1, DDX5, GRB7, HOXC8, USP9X, CRKL, GJA3, RXRG, NRXN2, MPP6, DBP, ACCN2, TCEA2, EPHB1, CCR1, ZBTB16, CD74, SLAMF1, APP, GLI1, MOS, SCG5, TRH, PTGS2, RAF1, MDFI, LASP1, LMO2, SORBS1, ADCYAP1, MAGI1, ACTN2, ACP1, BMP1, SIAH2, C1QA, CDC2, TLX1, HK3, RASA2, PRKAR2A, SRF, MMP7, NSF, ACTN3, MYF6, PEX6, FGR, CASP8, PCSK1, SALL1, CHRM3, PCGF2, ERC2, PAX5, HOXB2, PABPC1, SFRP1, CBX1, DFFB, FER, BLK, NTRK1, POLR2A, SMAD2, CTSG, NCOA1, HCK, CARD9, TRAF1, PEX19, PRKAB1, HAND2, SMAD7, CDK5, MDM2, SIX1, FANCA, POU3F2, RAC1, PLN, PAX2, SOX10, WT1, TRPV1, DYRK1A, RAP1A, TRPC3, NOS1, PER1, SYP, SLC8A1, FHL2, MEOX1, IGFALS, MEOX2, YBX1, PARP1, TAX1BP3, PDC, PCSK2, YWHAE, LAMA3, DLG4, IKBKAP, MSN, AXIN1, CDK2, WNT2, PPFIA1, PTK2, PPARA, TTN, KLF1, ARHGDIB, IL12A, RGS19, ELMO1, ITGB3, ACPP, LRP1, S100A1, CHN1, PARK2, PXN, HOXD4, CHAF1B, SP4, TRAF3, SNF1LK2, BRSK2, CAMK4, GZMA, TRAF3IP2, HCFC1, PRKACA, CREB3, SEPT8, HOMER1, ADRB2, GFAP, RFX1, CASK, NMI, FGF7, NOV, KCNA5, GRAP2, TJP1, ERBB2, ATG12, TP73, FRK, DNM2, MAP3K7IP1, MAPK14, ABLIM3, GNA12, TTR, EXOSC1, CCNT1, TNNT2, CTGF, LIFR, REN, ACTB, CSNK2B, IREB2, CRK, SNAP25, GABARAPL2, STAT5A, SGCG, RAC3, FABP4, MPP3, CRYAA, PLD1, CD28, RUNX1T1, FGFR1, DSG3, NAIP, OPRD1, ATXN2, TAL1, MARK1, TG, KRT8, ETS1, CREBBP, ANKRD1, IAPP, ATOX1, PDZK1, MYF5, PDE4DIP, KIFC3, PPARG, TRIP4, NPM1, RND1, PAWR, HEYL, BAI2, SMAD4, NOTCH4, TAF1, PPP3R1, APC2, MAP3K4, HCLS1, ZBTB33, CASP1, CHD1, ABL1, VIM, SH2D3C, CHAF1A, HOXA9, LRP2, EAF2, MME, LNPEP, NHLH1, MYT1, CD44, FES, SERPINA5, CTNNB1, ANXA13, HOXA5, PRKCA, CNTN1, PFTK1, TEC, PYCARD, SHC2, PARD6B, SLA, STAMBPL1, PPP1CA, MYH4, NFE2, STX12, WIPF1, EXOC3, MYC, PTPRS, STX1A, FGD1, PDE4D, MEIS1, SLC9A3, TP53, ZMYND11, SH3GL2, PPFIA4, NCK1, KIF5A, DIXDC1, CSF1R, ROPN1B, YWHAZ, HIC1, MAPK8IP1, COPS5, ASCL1, KDR, CR2, PPFIA2, VCP, IRS1, NTRK2, 674 12970 15360 1.1069599097666607 1.3818641786400576E-9 2.6072921599507026E-11 5.031419725298747E-10 GOTERM_BP_ALL GO:0009968~negative regulation of signal transduction 17 2.41% 1.8309673305097837E-5 AXIN1, PRKCA, CAV3, RGS2, CBLC, NFKBIA, OTUD7B, RGS19, SIX3, ADRBK1, LRP1, TAX1BP3, CAV1, RHOH, IGFBP3, MDFI, ADRB2, 674 108 15360 3.5872073854269697 0.0917175715910864 6.164759534006414E-4 0.03502031555325802 GOTERM_BP_ALL GO:0009967~positive regulation of signal transduction 18 2.55% 3.9173587340147304E-4 PPP5C, BCL10, TRAF6, GJA1, CARD9, HCLS1, CITED2, CASP1, MAP3K3, IL12A, REL, EDA2R, CASP8, IL4, TRAF3IP2, MAP3K7, TICAM1, ADRB2, 674 153 15360 2.681096177343341 0.8723653656322745 0.01013925513854852 0.7467296434701121 GOTERM_BP_ALL GO:0009966~regulation of signal transduction 49 6.94% 1.2595705263860113E-5 PPP5C, BCL10, CAV3, NFKBIA, REL, EDA2R, TAX1BP3, RHOH, MAP3K7, TICAM1, SMAD4, PLCE1, AXIN1, HCLS1, OTUD7B, CASP1, RGS19, IL12A, ADRBK1, LRP1, GLI1, SNF1LK2, IGFBP3, TRAF3IP2, MDFI, ADRB2, PRKCA, CBLC, RGS2, VAV1, RASA2, CITED2, GRM1, MAP3K3, CASP8, ARHGEF9, TRAF6, GJA1, CARD9, FGD1, ARRB1, REN, SIX3, CAV1, SMAD3, RAC1, MAPK8IP1, AKAP13, IL4, 674 573 15360 1.948824708313266 0.06403598825894152 4.381705463496477E-4 0.02409264289843227 GOTERM_BP_ALL GO:0006470~protein amino acid dephosphorylation 18 2.55% 8.523522771882448E-5 ACP1, KIT, CDC25A, PPP5C, PTPRS, PTPRH, PTPRG, PTPN6, PTPRZ1, CDC14A, PPEF1, PPP1CA, PTPN11, PPEF2, CDKN3, DUSP6, PTPRT, PTPRN, 674 135 15360 3.0385756676557865 0.36099626067962975 0.00258535147217398 0.16292778071350655 GOTERM_BP_ALL GO:0051179~localization 184 26.06% 1.624166592134174E-5 SLC2A2, TRPC3, PEX26, KCNJ8, TUBA3C, CAV3, HAP1, NFKBIA, SYP, SLC8A1, SNX17, STAT1, CAP1, DOC2B, BIN1, PLG, SNX5, MMP14, UPF1, SLC22A11, TAX1BP3, KCNJ2, STXBP1, COL1A2, FYN, WNT1, AKAP8, KCNK3, ATG7, S100A7, LAMA3, ATP7B, MSN, EXOC2, CCL8, WNT2, SCN3A, POU1F1, CPNE1, DOCK2, CHKA, SNX19, ADRA2A, PPARA, ARHGDIB, IL12A, CEBPE, GNAI3, ELMO1, ITGB3, KCNJ15, CACNA1B, LRP1, SLC34A1, PARK2, PXN, CAMK4, NGB, ADRB2, CLTCL1, HSPG2, AKAP3, VAV1, NLGN1, RPGR, SLC17A1, KCNA5, ITGB2, GAB1, TRPV6, PTPN11, DNM2, MAPK14, AR, STAU1, IL16, TTR, LAMA1, CP, GJA1, TNNT2, CTGF, ACTB, GJA8, TUBA1A, CRK, KCNJ9, SNAP25, GABARAPL2, CUBN, PICK1, FABP4, CAV1, ATP2B2, ACCN1, SMAD3, CRYAA, MAPK8, RBP4, KPNA2, ABCB4, LIN7A, KCNJ16, CALR, SLC9A1, KCNJ10, ATOX1, KCNB1, PDZK1, SLC17A7, KIFC3, EGFR, SYT11, NPM1, KCNJ12, GJA3, CRKL, NRXN2, ACHE, ACCN2, HSP90AA1, ELA2, VIM, SLC22A2, CD74, CSPG4, APP, LRP2, SCG5, PTGS2, ATP1B2, MDFI, SORBS1, LASP1, CTNNB1, LCP2, SLC6A1, PRKCA, BCL2L1, LIMK1, C1QA, CADM1, PYCARD, NSF, PARD6B, TWIST1, PEX6, SCN5A, STAT3, ITPR1, APBA2, MYH4, STX12, WIPF1, EXOC3, PRKG1, TIE1, STX1A, SLC9A3, TP53, SH3GL2, NCK1, PEX19, KIF5A, ZEB2, APBA1, GATA2, CDK5, ROPN1B, LCK, YWHAZ, ATG16L1, SIX1, ARF1, RAC1, MAPK8IP1, PLN, ASCL1, KDR, F11R, TRPV1, VCP, AKAP5, CBL, 674 3161 15360 1.3265531228614316 0.08179482002599314 5.575857052606548E-4 0.031065487546177994 GOTERM_BP_ALL GO:0006468~protein amino acid phosphorylation 91 12.89% 1.2039607243430189E-20 KIT, FGFR1, DYRK1A, GSK3A, MAPK1, SRC, MARK1, STAT1, TNFRSF14, MAP2K7, CDK3, FYN, NEK2, EGFR, PRKCG, CRKL, MAP3K7, ALK, IKBKAP, TAF1, CDK2, NUAK1, WNT2, MAP3K4, PRKD3, HCLS1, ROS1, EPHB1, PTK2, PIK3R1, ABL1, TTN, IL12A, ADRBK1, MOS, MAP3K14, SRPK1, SNF1LK2, BRSK2, RAF1, CAMK2A, CAMK4, IGFBP3, PRKACA, FES, PRKCA, LIMK1, PFTK1, CASK, CDC2, TEC, LIPE, CBLC, ABI1, PRKAR2A, IGF1R, MAP3K3, BMPR1A, ITGB2, PAK1, FGR, PRKCE, MAP3K5, CSNK1A1, CTBP1, ERBB2, CSNK2A1, FRK, FGF2, AXL, MAPK14, FER, BLK, NTRK1, EPHA3, PRKG1, TIE1, CCNT1, HCK, JUN, CSF1R, CDK5, LCK, PICK1, MAP3K8, KDR, IL4, MAPK8, EPHB2, NTRK2, FGFR4, 674 704 15360 2.9457782573509577 6.325609645698222E-17 3.0121950693801057E-18 2.303158677896091E-17 GOTERM_BP_ALL GO:0009952~anterior/posterior pattern formation 16 2.27% 2.256173874212627E-7 RNF2, SMAD2, ZEB2, BMPR1A, MEOX1, MYF6, NEUROD1, MEOX2, FOXH1, PCGF2, MYF5, SFRP1, EP300, CRKL, SMAD4, PRKDC, 674 69 15360 5.2844794220100635 0.0011846915855237006 1.1289401867786708E-5 4.3160177114476284E-4 GOTERM_BP_ALL GO:0051174~regulation of phosphorus metabolic process 11 1.56% 0.0020822729517433916 PRKCE, BCL10, PRKCA, HCLS1, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 674 78 15360 3.2138781100205436 0.9999824712511047 0.041402915162813025 3.909054772196663 GOTERM_BP_ALL GO:0006464~protein modification process 147 20.82% 4.729261773380057E-14 KIT, PPP5C, DYRK1A, SRC, PTPN6, UBE2O, CDC14A, CRY1, STAT1, PARP1, TNFRSF14, MMP14, MAP2K7, CDK3, PPEF1, FYN, PCSK2, NEK2, CDKN3, PRKCG, MAP3K7, ATG7, PLAT, ALK, IKBKAP, CDK2, NUAK1, WNT2, PRKD3, PTK2, OTUD7B, TTN, IL12A, ADRBK1, UBE2I, PARK2, MAP3K14, SRPK1, SNF1LK2, BRSK2, CAMK4, IGFBP3, PRKACA, USP2, DUSP6, PTPRH, CASK, ABI1, PTPRG, MAP3K3, ITGB2, PRKCE, MAP3K5, CSNK1A1, CTBP1, ERBB2, CSNK2A1, ATG12, FRK, FGF2, PTPN11, PPEF2, AXL, MAPK14, PTPRT, CARM1, PRKDC, EPHA3, CCNT1, VCPIP1, JUN, PTPRZ1, HDAC1, PICK1, IL4, GNA14, MAPK8, EPHB2, FGFR4, CDC25A, FGFR1, BCL10, GSK3A, MAPK1, MARK1, CREBBP, EGFR, USP9X, CRKL, RNF2, TAF1, ANAPC10, PPARGC1A, MAP3K4, HCLS1, ROS1, EPHB1, PIK3R1, ZBTB16, ABL1, LRP2, MOS, SCG5, CAMK2A, RAF1, MYT1, EP300, NEDD4, ACP1, FES, EPB42, SIAH2, PRKCA, LIMK1, PFTK1, CDC2, TEC, LIPE, CBLC, PRKAR2A, IGF1R, BMPR1A, PAK1, FGR, CHRM3, PCGF2, STAMBPL1, PPP1CA, FER, BLK, NTRK1, PTPRN, PRKG1, TIE1, TRAF6, PTPRS, HCK, TP53, CSF1R, CDK5, LCK, MDM2, MAP3K8, KDR, VCP, CBL, NTRK2, 674 1804 15360 1.8570009277109227 2.484905614608124E-10 5.402012170918624E-12 9.047207427670401E-11