Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_ALL GO:0006461~protein complex assembly 42 0.80% 1.805890298276353E-11 BCL10, LIN7A, SRC, WAS, LLGL1, MDM4, IGF1R, PARD6B, CREBBP, TJP1, WIPF1, WASL, SMAD4, DLG4, MPP6, AP2B1, GJA1, TGM2, APC2, TP53, SLC9A3R1, PTK2, TRAF1, NCK1, MBD2, CHAF1A, CD74, TLN1, DAG1, PICK1, MDM2, CHAF1B, FANCA, CAV1, SMAD3, KIFAP3, TGFBR1, PARD3, SLC9A3R2, ADRB2, CLTCL1, MAGI1, 652 295 15360 3.354060517833004 9.488139152136199E-8 1.5554326715516709E-9 3.454637687028139E-8 GOTERM_BP_ALL GO:0030324~lung development 9 0.17% 0.0011070490110935156 CTNNB1, FGFR1, WNT2, FGF2, MAP3K7IP1, EP300, BMPR1A, FGF1, CFTR, 652 50 15360 4.240490797546012 0.9970313780447414 0.02282925601154595 2.096649307003473 GOTERM_BP_ALL GO:0030323~respiratory tube development 9 0.17% 0.0012651444649079498 CTNNB1, FGFR1, WNT2, FGF2, MAP3K7IP1, EP300, BMPR1A, FGF1, CFTR, 652 51 15360 4.1573439191627575 0.998707629719277 0.02574620597675603 2.3926457948698077 GOTERM_BP_ALL GO:0045449~regulation of transcription 153 2.90% 1.0778045448454652E-5 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, POU1F1, PPARA, RFXANK, CEBPE, FOXH1, SRY, POU3F3, FOS, CHAF1B, HOXD4, TCF3, SMAD1, EYA1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, MCM7, ASCC2, ASF1A, ORC2L, TP73, BMI1, AR, FOXL2, ERCC2, CLIP1, HOXB9, UBB, RELB, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, DACH1, FABP4, SMAD3, IL4, TGFBR1, SREBF2, BCL10, ETS1, CALR, CREBBP, ANKRD1, MSC, EDA2R, MYF5, SMARCA4, FZD1, PLAG1, RHOH, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, NDN, ZBTB16, FOSL1, TAF13, VHL, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, PAX5, NCOR1, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, MEIS1, TP53, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, APBB1, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, SOX10, WT1, NCOA2, ERC1, 652 2598 15360 1.3873815157483105 0.05505462364427516 3.452340268994547E-4 0.020616223800529188 GOTERM_BP_ALL GO:0048009~insulin-like growth factor receptor signaling pathway 4 0.08% 0.005255204628673103 GRB10, PIK3R1, AKT1, IGF1R, 652 9 15360 10.47034764826176 0.9999999999990513 0.08676867970869917 9.58828678206337 GOTERM_BP_ALL GO:0016567~protein ubiquitination 12 0.23% 4.269633511272504E-4 RNF2, TRAF6, BCL10, MDM2, HDAC6, UBB, BMI1, AKT1, STUB1, PRKCG, VHL, VCP, 652 78 15360 3.624351109013686 0.893939381877698 0.009792720521194842 0.8136208983255511 GOTERM_BP_ALL GO:0009894~regulation of catabolic process 6 0.11% 0.002925906607290179 GJA1, MDM2, RELA, MDM4, STUB1, PRKCG, 652 24 15360 5.889570552147239 0.9999997939705756 0.05387311002521844 5.45121072655853 GOTERM_BP_ALL GO:0009893~positive regulation of metabolic process 52 0.99% 9.189071770141502E-11 CD28, TNK2, BCL10, GATA4, CREBBP, ERCC3, PTX3, EGFR, PRKCG, NR5A1, SMAD4, NOTCH4, POU1F1, HSP90AA1, FOSL1, PPARA, IL12A, PRKAA1, RB1, FOXH1, EBI3, APP, MYOG, HIF1A, SMAD1, TCF3, EP300, ADRB2, GTF2H1, CTNNB1, PRKCA, ASF1A, TP73, FGF2, FOXL2, ERCC2, SMAD2, GJA1, UBB, TP53, JUN, RELA, NCK1, HAND1, HAND2, ZNF423, SMAD3, TGFB1I1, IL4, SOX10, STUB1, NCOA2, 652 445 15360 2.752877921003653 4.827937118978554E-7 7.4275973149795504E-9 1.7578555278063845E-7 GOTERM_BP_ALL GO:0009892~negative regulation of metabolic process 48 0.91% 3.833872083440207E-9 SERPINA5, CTNNB1, PRKCA, MDM4, PER1, RBL1, TWIST1, STAT3, ORC2L, HDAC5, HDAC6, SMARCA4, HMGB1, FZD1, NCOR1, BMI1, CDKN1C, RYBP, PRKCG, SMAD4, RNF2, CBX2, CDC45L, TP53, ZMYND11, CLASP2, ZBTB16, JUN, RELA, VHL, MBD2, ZEB2, PRKAA1, SIX3, HAND1, RB1, DAXX, APBB1, ATR, MDM2, ZNF423, FABP4, CAV1, SMAD3, HDAC4, IGFBP3, MDFI, NCOA2, 652 436 15360 2.5935723532391513 2.0142961225433353E-5 2.650415977800691E-7 7.334139173753584E-6 GOTERM_BP_ALL GO:0007420~brain development 23 0.44% 1.0918669229487463E-6 NOTCH4, FRS2, PRKG1, CTNNB1, FGFR1, WNT2, POU1F1, IGF1R, SIX3, GATA2, CDK5R1, LRP2, IRS2, ATP2B2, SMARCA4, TP73, POU3F2, FYN, BMI1, FGF2, SMAD1, CFTR, ALK, 652 160 15360 3.3865030674846626 0.005720248662711369 4.2492963409301865E-5 0.0020887042558315194 GOTERM_BP_ALL GO:0009888~tissue development 29 0.55% 5.983429201352099E-4 BMP1, CTNNB1, WAS, DLX5, FGF7, BMPR1A, EDA2R, PLG, ERCC3, EGFR, NR5A1, S100A7, ERCC2, LAMA3, SMAD2, HCK, ALPL, AKT1, RELA, PPARA, CTGF, BMX, HAND1, CSPG4, FOXH1, POU3F2, SMAD3, PTGS2, ADRB2, 652 339 15360 2.0153102774309137 0.9569173356118323 0.013017178130991569 1.1384337791991106 GOTERM_BP_ALL GO:0009887~organ morphogenesis 34 0.64% 4.0197164940989044E-4 CTNNB1, FGFR1, MAPK1, DCN, DLX5, PITX2, IGF1R, CASP8, PLG, MYF5, PAX5, FGF2, MAP3K7IP1, FOXL2, MAP3K7, CRKL, S100A7, NOTCH4, FRS2, TGM2, POU1F1, ACTC1, AKT1, RELA, CTGF, FGF1, HAND1, CSPG4, HAND2, PAX3, ATP2B2, SIX1, PKD2, EP300, 652 415 15360 1.930076132751866 0.8790506763129503 0.009303284396963263 0.7661701237312357 GOTERM_BP_ALL GO:0007417~central nervous system development 35 0.66% 4.915482681358517E-9 CTNNB1, FGFR1, IGF1R, CDK5R1, IRS2, SMARCA4, TP73, FYN, BMI1, WNT1, FGF2, ALK, NOTCH4, FRS2, PRKG1, WNT2, POU1F1, SH3GL2, SH3GL3, NDN, ZBTB16, ZEB2, PTPRZ1, SIX3, GATA2, LRP2, POU3F3, PARK2, ATP2B2, POU3F2, NHLH1, SMAD1, SNTG2, GCM1, CFTR, 652 260 15360 3.1713072203869754 2.582561261699201E-5 3.3110181829609786E-7 9.403243705907727E-6 GOTERM_BP_ALL GO:0009880~embryonic pattern specification 8 0.15% 5.668505971336046E-4 NOTCH4, FRS2, MEOX2, CTNNB1, BMI1, HOXB6, SMAD1, MEOX1, 652 35 15360 5.3847502191060475 0.9491602862482525 0.012387395920007371 1.078822599273599 GOTERM_BP_ALL GO:0001775~cell activation 28 0.53% 3.189943108886701E-6 CD28, BCL10, WAS, VAV1, IL27RA, TNFRSF14, HDAC5, RHOH, MIF, RAG1, MAP3K7, PRKCD, NTRK1, RAG2, TRAF6, ZAP70, CASP3, RELB, PIK3R1, NCK1, IL12A, CD74, EBI3, CD2, SMAD3, HDAC4, TCF3, IL4, 652 238 15360 2.7715626127751714 0.016620320592104942 1.1172701024464438E-4 0.006102136523156165 GOTERM_BP_ALL GO:0016540~protein autoprocessing 10 0.19% 4.624567968771308E-4 WNT2, EGFR, JUN, AKT1, FER, TTN, MAP3K3, IGF1R, LMTK2, CFTR, 652 55 15360 4.283324037925265 0.911990455557172 0.01046567228216777 0.8809739722499987 GOTERM_BP_ALL GO:0001764~neuron migration 9 0.17% 8.381456896826133E-4 PRKG1, WNT2, CCR4, FYN, NDN, PSEN1, TWIST1, CFTR, CDK5R1, 652 48 15360 4.417177914110429 0.9877895595900407 0.017820783150294117 1.5912362535274838 GOTERM_BP_ALL GO:0016481~negative regulation of transcription 34 0.64% 5.318999853728041E-7 CTNNB1, MDM4, PER1, RBL1, TWIST1, STAT3, ORC2L, HDAC5, SMARCA4, HMGB1, FZD1, NCOR1, BMI1, RYBP, CDKN1C, SMAD4, RNF2, CBX2, ZMYND11, ZBTB16, VHL, ZEB2, MBD2, HAND1, SIX3, RB1, DAXX, ZNF423, MDM2, FABP4, SMAD3, HDAC4, MDFI, NCOA2, 652 300 15360 2.669938650306748 0.0027907019977667646 2.2356576219739743E-5 0.0010175117307609227 GOTERM_BP_ALL GO:0016477~cell migration 27 0.51% 9.020355816110974E-5 PRKCA, PSEN1, PARD6B, TWIST1, ITGB2, CDK5R1, GAB1, PLG, FYN, WNT1, EGFR, SIAH1, IL16, LAMA3, PRKG1, LAMA1, WNT2, UBB, DOCK2, NDN, NCK1, ZEB2, CTGF, IL12A, CCR4, SIX1, CFTR, 652 271 15360 2.3471351277929955 0.3774621634770843 0.0024151953993931663 0.17241701802120923 GOTERM_BP_ALL GO:0001756~somitogenesis 6 0.11% 0.002925906607290179 MEOX2, MYF5, SFRP1, ZEB2, EP300, MEOX1, 652 24 15360 5.889570552147239 0.9999997939705756 0.05387311002521844 5.45121072655853 GOTERM_BP_ALL GO:0007399~nervous system development 88 1.67% 3.863028007556679E-17 FGFR1, BCL10, MAFK, NAIP, GNAQ, BAI1, PSEN1, CDK5R1, IRS2, SMARCA4, MARK4, FYN, WNT1, HOXC8, RND1, HEYL, PMP22, MAP3K7, DLG4, NRXN2, ALK, NOTCH4, WNT2, POU1F1, EPHB1, ZBTB16, SH3GL3, NDN, TRPC5, APP, LRP2, POU3F3, PARK2, FOS, CCR4, NHLH1, BRSK2, SMAD1, MYT1, SNTG2, EP300, GCM1, CFTR, CTNNB1, LIMK1, DLX5, NLGN1, IGF1R, PLP1, PARD6B, TWIST1, CASP8, STAT3, MPZ, CHRM3, ERC2, TP73, PAX5, BMI1, FGF2, PTPN11, CHAT, CDKN1C, SIAH1, MCF2, NTRK1, FRS2, PRKG1, GJA1, UBB, SH3GL2, EPHA2, ZEB2, PTPRZ1, SIX3, GATA2, PICK1, APBB1, PAX3, ZNF423, SIX1, ATP2B2, POU3F2, BDNF, HDAC4, EPHB2, PARD3, NTRK2, 652 780 15360 2.6578574799433694 2.029634915170279E-13 6.150408833849331E-15 7.389914221175981E-14 GOTERM_BP_ALL GO:0032502~developmental process 290 5.50% 4.709230342799309E-42 KIT, CAPN3, MAFK, KCNJ8, HSPA5, FGF8, GATA4, LLGL1, GZMB, BAI1, HAP1, NFKBIA, STAT1, IRS2, TNFRSF25, HMGB1, FYN, PRM1, RAG1, PRKCG, S100A7, PLCE1, POU1F1, DUSP22, DFFA, BMX, ADRBK1, FOXH1, SRY, POU3F3, SRPK1, NTS, CASP5, GCM1, CLTCL1, NEDD9, PHOX2A, SERPINB2, NLGN1, ITGB2, MAP3K5, MPZ, PTPN11, FOXL2, HOXB9, LAMA1, CP, GJA1, AGTR2, UBB, RELB, E2F2, TUBB, JUN, CTSB, EPHA2, FGF1, PTPRZ1, HOXB7, PICK1, PAX3, CD2, ATP2B2, CAV1, GADD45G, TNFRSF1B, WRN, ACTN1, IL4, BCL10, MAPK1, DCN, IL27RA, EDA2R, CDK5R1, SMARCA4, HOXC8, NR5A1, PMP22, CRKL, NRXN2, RNF2, EPHB1, SH3GL3, ZBTB16, TRPC5, CD74, RB1, APP, PAK7, CCR4, RAF1, PTGS2, EP300, SNTG2, BAG4, MDFI, LMO2, GPR143, BMP1, CDC2, KNG1, WAS, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, CASP8, SALL1, CHRM3, TH, HDAC6, ERC2, PAX5, BICD1, MIF, PKP2, SFRP1, DFFB, CHAT, CDKN1C, SIAH1, NTRK1, SMAD2, PRKG1, SETDB1, HCK, CARD9, ACTC1, TRAF1, ZEB2, GATA2, HAND2, DAXX, CUGBP2, SIX1, POU3F2, BDNF, RAC1, TGFB1I1, HDAC4, PLN, SOX10, XAB2, F11R, IKBKG, CAV3, MEOX1, MEOX2, PLG, TNFRSF14, HDAC5, ERCC3, MARK4, WNT1, RYBP, MAP3K7, LAMA3, DLG4, ALK, AXIN1, WNT2, TGM2, CLASP2, NOL3, PPARA, ARHGDIB, TTN, IL12A, CEBPE, EIF5A, LRP1, DAG1, PARK2, FOS, HOXD4, TRAF3, BRSK2, TCF3, SMAD1, IGFBP3, EYA1, ADRB2, CFTR, FGF7, NOV, PLP1, CSRP3, ATG12, TP73, CCL17, BMI1, FGF2, MAP3K7IP1, AR, CASP2, GNA12, MCF2, ERCC2, FRS2, AKT1, ATG5, CTGF, REN, GJA8, HDAC1, SGCG, ATR, DACH1, RAC3, SMAD3, CRYAA, MAPK8, EPHB2, CD28, FGFR1, NAIP, GNAQ, ETS1, CALR, PSEN1, MYF5, FZD1, RHOH, EGFR, RND1, HEYL, SMAD4, TRAF5, NOTCH4, PPP3R1, SEPT4, BAD, ZAP70, CASP3, PIK3R1, NDN, VHL, PRKAA1, CSPG4, HOXA9, EAF2, LRP2, TRAIP, MYOG, MITF, TBP, NHLH1, HOXB6, MYT1, CD44, FES, CTNNB1, ANXA13, PRKCA, BCL2L1, LIMK1, MYOD1, CASP6, PARD6B, PAK1, RABEP1, NFE2, BUB1B, RAG2, TRAF6, MEIS1, TP53, PKD1, SH3GL2, ALPL, RELA, NCK1, DIXDC1, HAND1, SIX3, CSF1R, YWHAZ, APBB1, PLCG1, ZNF423, HIC1, PKD2, PARD3, VCP, NTRK2, ERC1, 652 3262 15360 2.0943905090407102 2.474229622106757E-38 1.2371148110533785E-38 9.008686505241564E-39 GOTERM_BP_ALL GO:0032501~multicellular organismal process 286 5.42% 1.5062029133143752E-28 KIT, CAPN3, MAFK, KCNJ8, FGF8, GATA4, BAI1, HAP1, NFKBIA, CRY1, IRS2, PPEF1, FYN, PRM1, RAG1, PLAT, S100A7, PLCE1, POU1F1, DUSP22, ARRB2, BMX, ADRBK1, FOXH1, CACNA1B, EBI3, SRY, SLC34A1, POU3F3, NTS, GCM1, MMP13, PHOX2A, RHO, NLGN1, SLC6A4, GRM1, ITGB2, MPZ, PTPN11, PPEF2, FOXL2, HOXB9, LAMA1, GJA1, AGTR2, UBB, DLG2, KCNV2, RELB, EPHA2, ARRB1, MBD2, FGF1, PTPRZ1, HOXB7, CUBN, PICK1, PAX3, CD2, ATP2B2, CAV1, CACNA1C, GADD45G, WRN, IL4, MMP3, BCL10, MAPK1, DCN, IL27RA, EDA2R, CDK5R1, SMARCA4, HOXC8, NR5A1, PMP22, GJA3, CRKL, SNCB, NRXN2, RNF2, EPHB1, SH3GL3, ZBTB16, TRPC5, CD74, RB1, APP, CCR4, CHGA, PTGS2, EP300, SNTG2, MDFI, LMO2, GPR143, BMP1, SLC6A1, C1QA, KNG1, WAS, DLX5, PITX2, IGF1R, BMPR1A, TWIST1, STAT3, SCN5A, CASP8, SALL1, CHRM3, TH, HDAC6, ERC2, PAX5, MIF, PKP2, SFRP1, CHAT, CDKN1C, SIAH1, NTRK1, SMAD2, PRKG1, OPRL1, MMP1, SETDB1, HCK, ACTC1, ZEB2, GATA2, HAND2, CUGBP2, SIX1, POU3F2, BDNF, HDAC4, PLN, APOH, SOX10, XAB2, TRPV1, IKBKG, CAV3, NOS1, VIPR1, MEOX1, MEOX2, PLG, PDC, HDAC5, ERCC3, MARK4, WNT1, RYBP, MAP3K7, LAMA3, ATP7B, DLG4, ALK, AXIN1, WNT2, TGM2, PPARA, ARHGDIB, TTN, IL12A, CEBPE, SNPH, S100A1, LRP1, DAG1, PARK2, FOS, HOXD4, BRSK2, CAMK4, TCF3, SMAD1, IGFBP3, EYA1, ADRB2, CFTR, SNCAIP, FGF7, PLP1, CSRP3, TP73, CCL17, BMI1, FGF2, MAP3K7IP1, AR, GNA12, MCF2, ERCC2, FRS2, AKT1, TNNT2, CTGF, REN, GJA8, GABARAPL2, SNAP25, SGCG, ATR, DACH1, RAC3, FABP4, SMAD3, CRYAA, EPHB2, CD28, FGFR1, NAIP, OPRD1, GNAQ, LIN7A, ETS1, PSEN1, MYF5, KIFC3, FZD1, MBL2, RHOH, EGFR, RND1, HEYL, KCNJ12, SMAD4, NOTCH4, PPP3R1, ZAP70, CASP3, PIK3R1, NDN, SLC22A2, CSPG4, HOXA9, LRP2, MYOG, MITF, AKAP9, NHLH1, HOXB6, MYT1, SAG, CD44, FES, CTNNB1, DTNA, PRKCA, LIMK1, MYOD1, CD46, PARD6B, NFE2, PCLO, RAG2, RYR2, TRAF6, STX1A, MEIS1, TP53, PDE4D, NPHP1, SH3GL2, ALPL, RELA, NCK1, KIF5A, DIXDC1, HAND1, SIX3, CSF1R, APBB1, PLAU, PLCG1, ZNF423, C5AR1, HIC1, PKD2, PARD3, NTRK2, ERC1, 652 3759 15360 1.7924098727471247 7.913590106553728E-25 7.913590106553727E-26 2.8813434195416675E-25 GOTERM_BP_ALL GO:0007389~pattern specification process 25 0.47% 4.650468674092392E-8 CTNNB1, PITX2, BMPR1A, MEOX1, MEOX2, MYF5, FGF2, BMI1, SFRP1, CRKL, SMAD4, SMAD2, RNF2, FRS2, NOTCH4, AXIN1, ZEB2, FGF1, FOXH1, SIX1, SMAD1, HOXB6, PKD2, EP300, MDFI, 652 157 15360 3.7513188230237193 2.4430578244216683E-4 2.493217605814557E-6 8.896272575276143E-5 GOTERM_BP_ALL GO:0051049~regulation of transport 17 0.32% 5.1236139552598476E-5 GJA1, PRKCA, CAV3, NFKBIA, PRKAA1, GATA2, SNX17, RHOA, PTX3, TRPV6, SMAD3, PTPN11, RAC1, PLN, CRYAA, MDFI, ADRB2, 652 121 15360 3.309841302033159 0.23601076000651955 0.0014011090585471786 0.09796845152042488 GOTERM_BP_ALL GO:0045321~leukocyte activation 28 0.53% 2.68787668317244E-7 CD28, BCL10, WAS, VAV1, IL27RA, TNFRSF14, HDAC5, RHOH, MIF, RAG1, MAP3K7, PRKCD, NTRK1, RAG2, TRAF6, ZAP70, CASP3, RELB, PIK3R1, NCK1, IL12A, CD74, EBI3, CD2, SMAD3, HDAC4, TCF3, IL4, 652 210 15360 3.1411042944785277 0.0014112138991270173 1.1967814819713318E-5 5.141854962364967E-4 GOTERM_BP_ALL GO:0006366~transcription from RNA polymerase II promoter 79 1.50% 2.7343132655653936E-16 GATA4, POU2AF1, ANKRD1, MSC, STAT1, YBX1, PARP1, HDAC5, MYF5, ERCC3, HMGB1, TFCP2, SMARCA4, TRIP4, RYBP, NR5A1, SMAD4, CBX2, RNF2, DBP, POU1F1, PPARA, RFXANK, FOSL1, VHL, RB1, FOXH1, APP, FOS, MYOG, TBP, HIF1A, SMAD1, EP300, MDFI, ADRB2, CTNNB1, GTF2H1, MAX, PHOX2A, NMI, MDM4, MYOD1, RBL1, TWIST1, STAT3, ORC2L, PAX5, NCOR1, BMI1, NFE2, CDKN1C, FOXL2, ERCC2, MYC, SMAD2, MLLT1, RFXAP, TP53, ZMYND11, TFDP2, E2F2, JUN, MBD2, HAND1, GATA2, HAND2, GTF2F2, PAX3, MDM2, POU3F2, TGFB1I1, SMAD3, HDAC4, COPS5, SOX10, IL4, SREBF2, NCOA2, 652 669 15360 2.781919722688382 1.1666223542761145E-12 3.1530333899354446E-14 4.218847493575595E-13 GOTERM_BP_ALL GO:0006357~regulation of transcription from RNA polymerase II promoter 57 1.08% 3.6351516287743416E-12 ANKRD1, HDAC5, ERCC3, HMGB1, TFCP2, SMARCA4, MYF5, RYBP, NR5A1, SMAD4, CBX2, RNF2, DBP, POU1F1, FOSL1, PPARA, VHL, RB1, FOXH1, APP, FOS, MYOG, HIF1A, SMAD1, EP300, MDFI, ADRB2, CTNNB1, GTF2H1, MYOD1, MDM4, RBL1, TWIST1, STAT3, ORC2L, BMI1, NFE2, CDKN1C, FOXL2, ERCC2, MYC, SMAD2, TP53, ZMYND11, TFDP2, JUN, MBD2, HAND1, HAND2, MDM2, POU3F2, SMAD3, HDAC4, IL4, SOX10, SREBF2, NCOA2, 652 476 15360 2.8210548022890136 1.9099357650986803E-8 3.410599580533358E-10 6.954092857114347E-9 GOTERM_BP_ALL GO:0030183~B cell differentiation 8 0.15% 4.7046645086169987E-4 RAG2, HDAC5, HDAC4, PIK3R1, TCF3, IL4, RAG1, NTRK1, 652 34 15360 5.543125225550343 0.9156189452174441 0.010555111594017341 0.8961672565044543 GOTERM_BP_ALL GO:0030182~neuron differentiation 29 0.55% 2.6766709140849628E-6 GNAQ, LIMK1, DLX5, NLGN1, BAI1, PARD6B, CDK5R1, PTPN11, HOXC8, CHAT, CDKN1C, RND1, SIAH1, MCF2, PRKG1, GJA1, UBB, NDN, EPHA2, PTPRZ1, GATA2, APP, PICK1, APBB1, ATP2B2, SIX1, POU3F2, BRSK2, PARD3, 652 250 15360 2.732760736196319 0.01396482226927187 9.631897612694118E-5 0.005120306783990003 GOTERM_BP_ALL GO:0006355~regulation of transcription, DNA-dependent 145 2.75% 1.0566285855637133E-5 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, POU1F1, PPARA, RFXANK, CEBPE, FOXH1, SRY, POU3F3, FOS, CHAF1B, HOXD4, TCF3, SMAD1, EYA1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, MCM7, ASCC2, ASF1A, ORC2L, TP73, BMI1, AR, FOXL2, ERCC2, CLIP1, HOXB9, RELB, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, DACH1, SMAD3, IL4, SREBF2, BCL10, ETS1, CALR, CREBBP, ANKRD1, MSC, MYF5, SMARCA4, PLAG1, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, NDN, ZBTB16, FOSL1, TAF13, VHL, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, NCOR1, PAX5, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, MEIS1, TP53, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, SOX10, WT1, NCOA2, ERC1, 652 2432 15360 1.4045850823377461 0.054002695388787325 3.4052825973973633E-4 0.020211209270493136 GOTERM_BP_ALL GO:0007369~gastrulation 8 0.15% 0.002025968773729387 FRS2, SMAD2, RNF2, CTNNB1, FGF8, SMAD3, HAND1, SMAD4, 652 43 15360 4.3829362248537596 0.9999764229593753 0.03897835578139541 3.805287110796962 GOTERM_BP_ALL GO:0006351~transcription, DNA-dependent 149 2.82% 5.656316793513344E-6 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, POU1F1, PPARA, RFXANK, CEBPE, FOXH1, SRY, POU3F3, FOS, CHAF1B, HOXD4, TCF3, SMAD1, EYA1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, NMI, MCM7, ASCC2, ASF1A, ORC2L, TP73, BMI1, AR, FOXL2, ERCC2, CLIP1, HOXB9, RELB, RFXAP, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, DACH1, SMAD3, IL4, SREBF2, BCL10, ETS1, CALR, CREBBP, ANKRD1, MSC, MYF5, SMARCA4, PLAG1, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, NDN, ZBTB16, FOSL1, TAF13, VHL, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, NCOR1, PAX5, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, MEIS1, TP53, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, COPS5, SOX10, WT1, NCOA2, ERC1, 652 2487 15360 1.411412967060617 0.029281123795339314 1.942188657102495E-4 0.010819893787483714 GOTERM_BP_ALL GO:0006350~transcription 159 3.01% 5.900610335951171E-6 HSF1, PPP5C, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, POU1F1, PPARA, RFXANK, CEBPE, FOXH1, SRY, POU3F3, FOS, CHAF1B, HOXD4, TCF3, SMAD1, EYA1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, NMI, MCM7, ASCC2, ASF1A, ORC2L, TP73, BMI1, AR, FOXL2, CLIP1, ERCC2, HOXB9, UBB, RELB, RFXAP, ATF7IP2, E2F2, JUN, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, DACH1, FABP4, SMAD3, IL4, TGFBR1, SREBF2, BCL10, ETS1, CALR, CREBBP, ANKRD1, MSC, EDA2R, MYF5, SMARCA4, FZD1, PLAG1, RHOH, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, ZBTB16, NDN, FOSL1, TAF13, VHL, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, PAX5, NCOR1, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, MEIS1, TP53, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, APBB1, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, COPS5, SOX10, XAB2, WT1, NCOA2, ERC1, 652 2695 15360 1.3898949429186065 0.030526267151625874 2.0129076537245272E-4 0.011287174687335533 GOTERM_BP_ALL GO:0016311~dephosphorylation 19 0.36% 7.184177599325824E-5 KIT, CDC25A, PPM1A, PPP5C, PTPRS, PTPN7, DUSP22, PTPRG, PTPRZ1, CDC14A, PPEF1, PTPRM, PTPN21, PTPN11, PPP2R2A, PPEF2, CDKN3, DUSP6, PTPRN, 652 151 15360 2.9642871653191403 0.31440640251364815 0.0019438312479013176 0.13734276748864627 GOTERM_BP_ALL GO:0016310~phosphorylation 100 1.90% 3.706284291154944E-20 KIT, SRC, STAT1, JAK1, MAP2K7, TNFRSF14, CDK3, TEK, FYN, MARK4, PRKCG, MAP3K7, PRKCD, ALK, ABL2, AKT2, NUAK1, WNT2, MARK3, PRKD3, PTK2, BMX, TTN, IL12A, ADRBK1, CHEK1, MAP3K14, SRPK1, BRSK2, CAMK4, IGFBP3, PRKACA, CSNK1E, CFTR, CASK, MCM7, MAP3K3, ITGB2, MAP3K5, CSNK1A1, CTBP1, CSNK2A1, FGF2, FRK, MAPK14, JUN, AKT1, EPHA2, RPS6KA1, PICK1, IL4, MAPK8, TGFBR1, EPHB2, MAPK3, FGFR4, TNK2, BCL10, FGFR1, GSK3A, MAPK1, MARK1, PSEN1, EGFR, CRKL, BCR, ZAP70, MAP3K4, EPHB1, PIK3R1, PRKAA1, PAK7, GUCY2C, CAMK2A, RAF1, FES, LIMK1, PRKCA, CDC2, PFTK1, LIPE, MYOD1, PRKAR2A, IGF1R, BMPR1A, PAK1, FER, NTRK1, BUB1B, PRKG1, HCK, MAPKAPK2, STK11, LMTK2, CSF1R, PKN1, MAP3K8, NTRK2, ERC1, MYLK, 652 867 15360 2.7172182478187956 1.9472817665728077E-16 7.48954525604926E-18 7.090065859566566E-17 GOTERM_BP_ALL GO:0030154~cell differentiation 192 3.64% 1.4321990911317047E-34 HSPA5, IKBKG, GZMB, NFKBIA, BAI1, STAT1, TNFRSF25, PLG, TNFRSF14, HDAC5, HMGB1, ERCC3, MARK4, FYN, WNT1, RYBP, PRM1, PRKCG, RAG1, MAP3K7, S100A7, LAMA3, AXIN1, WNT2, TGM2, DUSP22, NOL3, DFFA, TTN, IL12A, CEBPE, EIF5A, SRY, SRPK1, TRAF3, BRSK2, TCF3, IGFBP3, CASP5, GCM1, ADRB2, CFTR, SERPINB2, NLGN1, PLP1, ITGB2, CSRP3, MAP3K5, ATG12, TP73, PTPN11, FGF2, FOXL2, CASP2, GNA12, MCF2, ERCC2, FRS2, GJA1, AGTR2, UBB, RELB, E2F2, TUBB, JUN, CTSB, AKT1, ATG5, EPHA2, CTGF, REN, FGF1, PTPRZ1, HDAC1, PICK1, PAX3, CD2, ATP2B2, SMAD3, WRN, TNFRSF1B, GADD45G, ACTN1, IL4, CRYAA, MAPK8, CD28, FGFR1, BCL10, NAIP, GNAQ, MAPK1, ETS1, CALR, PSEN1, CDK5R1, EDA2R, MYF5, SMARCA4, FZD1, RHOH, HOXC8, RND1, NR5A1, TRAF5, NOTCH4, PPP3R1, SEPT4, BAD, ZAP70, CASP3, ZBTB16, PIK3R1, NDN, VHL, PRKAA1, CD74, CSPG4, RB1, APP, EAF2, TRAIP, PAK7, MYOG, CCR4, MITF, TBP, NHLH1, PTGS2, RAF1, MYT1, EP300, MDFI, BAG4, LMO2, BMP1, CTNNB1, ANXA13, PRKCA, BCL2L1, LIMK1, CDC2, KNG1, DLX5, MDM4, MYOD1, IGF1R, CASP6, BMPR1A, PARD6B, TWIST1, PAK1, CASP8, RABEP1, SALL1, PAX5, MIF, SFRP1, DFFB, CHAT, CDKN1C, SIAH1, NTRK1, BUB1B, SMAD2, RAG2, PRKG1, TRAF6, CARD9, TP53, ACTC1, TRAF1, RELA, ZEB2, HAND1, GATA2, HAND2, DAXX, YWHAZ, CUGBP2, APBB1, ZNF423, SIX1, POU3F2, TGFB1I1, HDAC4, SOX10, F11R, PARD3, VCP, NTRK2, ERC1, 652 1835 15360 2.464953778773341 7.524774024805977E-31 1.2541290041343293E-31 2.7397752256535287E-31 GOTERM_BP_ALL GO:0016265~death 101 1.91% 6.530316300059352E-22 IKBKG, HSPA5, GZMB, NFKBIA, STAT1, PLG, TNFRSF25, TNFRSF14, ERCC3, HMGB1, MARK4, RYBP, PRKCG, MAP3K7, AXIN1, TGM2, DUSP22, NOL3, DFFA, IL12A, EIF5A, TRAF3, IGFBP3, CASP5, ADRB2, SERPINB2, ITGB2, MAP3K5, ATG12, TP73, FGF2, FOXL2, CASP2, ERCC2, GJA1, AGTR2, TUBB, E2F2, CTSB, ATG5, AKT1, HDAC1, PAX3, CD2, SMAD3, GADD45G, TNFRSF1B, WRN, ACTN1, IL4, MAPK8, CRYAA, CD28, BCL10, NAIP, MAPK1, CALR, PSEN1, CDK5R1, TRAF5, SEPT4, BAD, CASP3, PIK3R1, ZBTB16, VHL, PRKAA1, CD74, APP, TRAIP, EAF2, PAK7, TBP, RAF1, EP300, BAG4, BCL2L1, PRKCA, CDC2, KNG1, MDM4, CASP6, IGF1R, PAK1, CASP8, RABEP1, MIF, SFRP1, DFFB, SIAH1, BUB1B, TRAF6, CARD9, TP53, ACTC1, RELA, TRAF1, DAXX, YWHAZ, VCP, ERC1, 652 834 15360 2.8529814185461446 3.4310281840511838E-18 1.429595076687993E-19 1.2492396431034127E-18 GOTERM_BP_ALL GO:0032446~protein modification by small protein conjugation 12 0.23% 7.319255135908184E-4 RNF2, TRAF6, BCL10, MDM2, HDAC6, UBB, BMI1, AKT1, STUB1, PRKCG, VHL, VCP, 652 83 15360 3.406016704856235 0.9786551472780302 0.015706395597549827 1.3909112938654489 GOTERM_BP_ALL GO:0042330~taxis 24 0.45% 7.363903613308085E-8 CXCL2, CCL8, CCL7, PRKCA, MAPK1, DOCK2, CCR1, CCR3, FOSL1, IL8RA, ITGB2, CCL13, RALA, PLAU, C5AR1, CCR4, CCL5, CCL17, FGF2, IL4, MAPK14, FER, DEFB1, IL16, 652 149 15360 3.794622637625067 3.868246739046066E-4 3.7201806749598276E-6 1.408702695715469E-4 GOTERM_BP_ALL GO:0009798~axis specification 7 0.13% 1.318384232456158E-4 FRS2, RNF2, AXIN1, CTNNB1, HOXB6, MDFI, BMPR1A, 652 20 15360 8.245398773006135 0.49978873540216484 0.003357093776523934 0.2519037273762792 GOTERM_BP_ALL GO:0042325~regulation of phosphorylation 12 0.23% 2.673780507508948E-4 TNK2, BCL10, PRKCA, FGF2, MCM7, EGFR, JUN, IL4, IGFBP3, IL12A, PSEN1, ITGB2, 652 74 15360 3.8202619797711823 0.7546310098124764 0.00642419403866179 0.5102523322279673 GOTERM_BP_ALL GO:0009792~embryonic development ending in birth or egg hatching 17 0.32% 2.7151678148683108E-5 BCL10, SETDB1, ZEB2, MEOX1, HAND2, MEOX2, CASP8, PLCG1, MYF5, SMARCA4, SIX1, SFRP1, MAP3K7IP1, XAB2, EP300, MAP3K7, GNA12, 652 115 15360 3.48252867431315 0.1329484566071235 8.011219285893878E-4 0.051927968041909356 GOTERM_BP_ALL GO:0009790~embryonic development 42 0.80% 2.7922360022833953E-11 CTNNB1, FGFR1, BCL10, GNAQ, FGF8, DLX5, MEOX1, EDA2R, CDK5R1, MEOX2, CASP8, MYF5, SMARCA4, BMI1, SFRP1, MAP3K7IP1, FOXL2, MAP3K7, GNA12, SMAD4, LAMA3, NOTCH4, FRS2, SMAD2, RNF2, LAMA1, SETDB1, ZBTB16, ZEB2, HAND1, HAND2, FOXH1, PICK1, PLCG1, SIX1, ATP2B2, SMAD3, HOXB6, SMAD1, XAB2, EP300, MDFI, 652 299 15360 3.3091901430124957 1.4670391690341233E-7 2.3286337302863558E-9 5.34149946496143E-8 GOTERM_BP_ALL GO:0030098~lymphocyte differentiation 13 0.25% 1.3021328701860998E-4 RAG2, ZAP70, RELB, PIK3R1, CD74, CD2, HDAC5, RHOH, HDAC4, IL4, TCF3, RAG1, NTRK1, 652 80 15360 3.8282208588957056 0.4954988481106143 0.0033646969042010477 0.24880224307634036 GOTERM_BP_ALL GO:0030097~hemopoiesis 23 0.44% 2.1955886927212116E-5 NOTCH4, KIT, RAG2, CTNNB1, ZAP70, RELB, NFKBIA, PIK3R1, ZBTB16, ETS1, CEBPE, CD74, CASP8, RB1, CD2, HDAC5, RHOH, HDAC4, TCF3, IL4, RAG1, NTRK1, LMO2, 652 192 15360 2.822085889570552 0.1089524592458413 6.627543979332851E-4 0.04199292161058965 GOTERM_BP_ALL GO:0042311~vasodilation 7 0.13% 1.318384232456158E-4 WNT2, AGTR2, KCNJ8, CAV1, KNG1, ADRB2, CFTR, 652 20 15360 8.245398773006135 0.49978873540216484 0.003357093776523934 0.2519037273762792 GOTERM_BP_ALL GO:0016192~vesicle-mediated transport 40 0.76% 2.62341594305102E-4 CTNNB1, LIN7A, WAS, VAV1, NLGN1, SYP, SNX17, RABEP1, KIF1C, RAB6A, TRPV6, PTX3, STXBP1, CCL5, PCLO, EXOC3, EXOC2, AP2B1, CCL8, SNAP91, SYNJ1, STX1A, CPNE1, SH3GL2, SH3GL3, CEBPE, GATA2, SNPH, SNAP25, LRP1, CUBN, APP, LRP2, PICK1, TSC2, RAC1, MAPK8IP3, ERC1, ADRB2, CLTCL1, 652 509 15360 1.8513384839755567 0.7480497335792433 0.006361731499616163 0.5006638267214814 GOTERM_BP_ALL GO:0045165~cell fate commitment 14 0.27% 9.131485547137691E-5 SMAD2, FRS2, NOTCH4, CTNNB1, MYOD1, FGF1, PSEN1, GATA2, SALL1, SMARCA4, WNT1, FGF2, TCF3, GCM1, 652 89 15360 3.705797201351072 0.3810867471839867 0.0024325196477263944 0.17453941765036562 GOTERM_BP_ALL GO:0030036~actin cytoskeleton organization and biogenesis 23 0.44% 9.256315691271081E-5 ABL2, PRKG1, LIMK1, DOCK2, WAS, NPHP1, ACTC1, LLGL1, NCK1, ARHGDIB, TTN, CALR, FHOD1, FMNL1, RHOA, PDE4DIP, RAC3, RAC1, ACTN1, WIPF1, RND1, WASL, NEDD9, 652 211 15360 2.567964411362777 0.3851330252439653 0.00245329551630713 0.1769234221985827 GOTERM_BP_ALL GO:0046777~protein amino acid autophosphorylation 10 0.19% 3.4754747347798514E-4 WNT2, EGFR, JUN, AKT1, FER, TTN, MAP3K3, IGF1R, LMTK2, CFTR, 652 53 15360 4.4449589072809355 0.8389969246365132 0.008120119287346572 0.6627626033960166 GOTERM_BP_ALL GO:0030030~cell projection organization and biogenesis 20 0.38% 0.005467299183564665 PRKG1, GJA1, UBB, LIMK1, DLX5, BAI1, NDN, NCK1, PTPRZ1, PARD6B, CDK5R1, APBB1, RAC3, POU3F2, RAC1, PTPN11, CHAT, SIAH1, PARD3, MCF2, 652 235 15360 2.004960187965018 0.9999999999996906 0.08873007941685407 9.956343626704744 GOTERM_BP_ALL GO:0030029~actin filament-based process 25 0.47% 3.349256614180481E-5 LIMK1, WAS, LLGL1, CALR, FMNL1, FHOD1, PDE4DIP, WASL, RND1, WIPF1, PRKG1, ABL2, DOCK2, NPHP1, ACTC1, TNNT2, NCK1, TTN, ARHGDIB, RHOA, APBB1, RAC3, RAC1, ACTN1, NEDD9, 652 226 15360 2.606004669091699 0.16135928093264096 9.405888629284709E-4 0.06405132441705819 GOTERM_BP_ALL GO:0006281~DNA repair 22 0.42% 0.004886321129756333 XPA, GTF2H1, TP53, ASF1A, CHAF1A, CRY1, PARP1, ATR, ERCC4, CHEK1, CHAF1B, HMGB1, ERCC3, FANCA, TP73, RAD52, GADD45G, PRKCG, XAB2, VCP, CSNK1E, ERCC2, 652 267 15360 1.941131867374371 0.999999999993345 0.08220895091527614 8.94474857025318 GOTERM_BP_ALL GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 25 0.47% 6.740107283308216E-8 CCL7, PRKCA, KNG1, CCR3, CALR, CSRP3, CCL13, ATOX1, CCL5, ATP7B, PLCE1, MYC, CP, RYR2, OPRL1, TGM2, CCR1, IREB2, APP, CACNA1C, ATP2B2, CCR4, C5AR1, PLN, PKD2, 652 160 15360 3.6809815950920246 3.5406255365955097E-4 3.4718101360464715E-6 1.2893715535255978E-4 GOTERM_BP_ALL GO:0030003~cellular cation homeostasis 25 0.47% 7.013802912186901E-7 CCL7, PRKCA, KNG1, CCR3, CALR, CSRP3, CCL13, ATOX1, CCL5, ATP7B, PLCE1, MYC, CP, RYR2, OPRL1, TGM2, CCR1, IREB2, APP, CACNA1C, ATP2B2, CCR4, C5AR1, PLN, PKD2, 652 181 15360 3.25390638240179 0.003678271865692251 2.9015747083582788E-5 0.0013417213709177034 GOTERM_BP_ALL GO:0030001~metal ion transport 34 0.64% 0.0012334460668359188 TRPC4, KCNJ8, CAV3, KCNJ16, SLC9A1, KCNJ10, SCN5A, ATOX1, ITPR1, KCNB1, TRPV6, KCNJ2, FYN, KCNN2, KCNJ12, ATP7B, RYR2, CP, CCL8, GJA1, ACCN2, KCNV2, TRPC5, SLC22A2, KCNJ9, KCNJ15, CACNA1B, SLC34A1, CACNA1C, ATP2B2, PLN, PKD2, TRPV1, ADRB2, 652 443 15360 1.8080848647675496 0.9984731150724435 0.02520650303566363 2.333366074846266 GOTERM_BP_ALL GO:0001505~regulation of neurotransmitter levels 14 0.27% 2.9029980853161603E-5 LIN7A, PHOX2A, NLGN1, SLC6A4, SNCAIP, SNPH, CACNA1B, SNAP25, PARK2, TH, CHAT, PCLO, SNCB, NRXN2, 652 80 15360 4.122699386503068 0.14146319933261164 8.423286513988826E-4 0.05551930324527721 GOTERM_BP_ALL GO:0042221~response to chemical stimulus 57 1.08% 3.21837164875545E-8 HSF1, CXCL2, ASIP, BCL10, DNAJC3, ABCB4, MAPK1, NFKBIA, ATOX1, RALA, IRS2, ERCC3, MBL2, PRKCG, DEFB1, S100A7, ATP7B, XPA, CCL8, WNT2, HSP90AA1, DOCK2, CCR1, FOSL1, IL8RA, TTN, CCR4, GUCY2C, TRH, PTGS2, GNAI2, CFTR, CCL7, PRKCA, LIPE, CCR3, ITGB2, GAB1, CCL13, CCL5, FGF2, CCL17, FER, MAPK14, IL16, ERCC2, RAG2, CP, RELA, TNNT2, AKT1, REN, PLAU, C5AR1, IL4, TRPV1, VCP, 652 606 15360 2.2158780295207436 1.690789535947479E-4 1.8581658456362504E-6 6.156694545289554E-5 GOTERM_BP_ALL GO:0009719~response to endogenous stimulus 33 0.63% 5.019953545039534E-4 ASIP, GTF2H1, MAPK1, CDC2, MCM7, ASF1A, CRY1, IRS2, PARP1, ERCC4, ERCC3, HMGB1, TP73, PTPN11, PRKCG, ERCC2, XPA, WNT2, TP53, AKT1, REN, CHAF1A, ATR, CHEK1, FANCA, CHAF1B, RAD52, GADD45G, TRH, XAB2, VCP, CSNK1E, CFTR, 652 403 15360 1.9290901064105102 0.9285062908057773 0.011210812609308562 0.9559520937417965 GOTERM_BP_ALL GO:0022610~biological adhesion 58 1.10% 3.28153304251806E-5 DSC1, SYMPK, BCL10, DSG3, BAI1, PSEN1, CDK5R1, IGFALS, MYF5, EGFR, RND1, LAMA3, NRXN2, ABL2, TGM2, JAM2, PPFIA1, CCR1, TTN, ARHGDIB, IL12A, DAG1, APP, CD44, NEDD9, CTNND1, MAGI1, HSPG2, BMP1, CTNNB1, CASK, VAV1, KNG1, NLGN1, CCR3, ITGB2, MPZ, PTPRM, CCL5, PKP2, FER, LAMA1, PTPRS, NPHP1, PKD1, PSTPIP1, ZEB2, CTGF, CD2, DSG2, SELE, TGFB1I1, RAC1, ACTN1, MLLT4, PKD2, F11R, PPFIA2, 652 774 15360 1.7653493127883197 0.15836981799240557 9.265305858150441E-4 0.06275656121993434 GOTERM_BP_ALL GO:0022607~cellular component assembly 56 1.06% 6.275879220544358E-8 BCL10, LIN7A, SRC, LLGL1, CREBBP, HDAC5, HMGB1, SMARCA4, SFRS2IP, WASL, SMAD4, DLG4, MPP6, TGM2, APC2, SLC9A3R1, PTK2, TAF13, TTN, CHAF1A, CD74, EIF5A, DAG1, CHAF1B, TBP, CLTCL1, MAGI1, ADRB2, WAS, MDM4, IGF1R, ASF1A, PARD6B, HIST3H3, TJP1, WIPF1, GJA1, AP2B1, SNAP91, TP53, E2F2, ACTC1, TRAF1, NCK1, MBD2, TLN1, PICK1, GTF2F2, MDM2, CAV1, FANCA, SMAD3, KIFAP3, TGFBR1, PARD3, SLC9A3R2, 652 602 15360 2.1914681124268798 3.296803478587407E-4 3.2646947141223848E-6 1.2005655303237717E-4 GOTERM_BP_ALL GO:0006259~DNA metabolic process 57 1.08% 8.809080320712044E-4 KPNA2, IL27RA, CREBBP, CRY1, PARP1, HDAC5, ERCC3, HMGB1, SMARCA4, CBX5, PRM1, RAG1, PRKCG, CBX2, RNF2, XPA, DFFA, RCC1, CHAF1A, RB1, FOS, CHEK1, CHAF1B, EP300, CSNK1E, GTF2H1, MCM7, RBL1, ASF1A, HIST3H3, ORC2L, ERCC4, HDAC6, NCOR1, TP73, BMI1, PPFIBP2, DFFB, FOXL2, ERCC2, RAG2, SETDB1, CDC45L, TP53, TFDP2, CTGF, HDAC1, PICK1, ATR, FANCA, RAD52, GADD45G, WRN, HDAC4, IL4, XAB2, VCP, 652 860 15360 1.5614210301041516 0.990248464778448 0.01857165891287127 1.6717745568428866 GOTERM_BP_ALL GO:0007275~multicellular organismal development 212 4.02% 2.6176203858237407E-29 KIT, MAFK, CAPN3, KCNJ8, FGF8, GATA4, BAI1, HAP1, NFKBIA, IRS2, FYN, PRM1, RAG1, S100A7, PLCE1, POU1F1, DUSP22, BMX, ADRBK1, FOXH1, SRY, POU3F3, NTS, GCM1, NLGN1, ITGB2, MPZ, PTPN11, FOXL2, HOXB9, LAMA1, GJA1, AGTR2, UBB, RELB, EPHA2, PTPRZ1, FGF1, HOXB7, PICK1, CD2, PAX3, ATP2B2, CAV1, GADD45G, WRN, IL4, BCL10, MAPK1, DCN, IL27RA, EDA2R, CDK5R1, SMARCA4, HOXC8, NR5A1, PMP22, CRKL, NRXN2, RNF2, EPHB1, SH3GL3, ZBTB16, TRPC5, CD74, RB1, APP, CCR4, PTGS2, EP300, SNTG2, MDFI, LMO2, BMP1, WAS, KNG1, DLX5, PITX2, IGF1R, BMPR1A, TWIST1, STAT3, CASP8, SALL1, CHRM3, HDAC6, ERC2, PAX5, PKP2, SFRP1, CDKN1C, CHAT, SIAH1, NTRK1, SMAD2, PRKG1, SETDB1, HCK, ACTC1, ZEB2, GATA2, HAND2, CUGBP2, SIX1, POU3F2, BDNF, HDAC4, PLN, XAB2, CAV3, MEOX1, MEOX2, PLG, HDAC5, ERCC3, MARK4, WNT1, RYBP, MAP3K7, LAMA3, ALK, DLG4, AXIN1, WNT2, TGM2, PPARA, TTN, ARHGDIB, CEBPE, LRP1, FOS, PARK2, HOXD4, BRSK2, SMAD1, TCF3, IGFBP3, EYA1, CFTR, ADRB2, FGF7, PLP1, CSRP3, TP73, FGF2, BMI1, CCL17, MAP3K7IP1, AR, MCF2, GNA12, ERCC2, FRS2, AKT1, CTGF, GJA8, DACH1, ATR, SGCG, SMAD3, EPHB2, FGFR1, NAIP, GNAQ, ETS1, PSEN1, MYF5, FZD1, RHOH, EGFR, RND1, HEYL, SMAD4, NOTCH4, PPP3R1, ZAP70, CASP3, NDN, PIK3R1, CSPG4, HOXA9, LRP2, MYOG, MITF, NHLH1, HOXB6, MYT1, CD44, FES, CTNNB1, LIMK1, MYOD1, PARD6B, NFE2, RAG2, MEIS1, TP53, SH3GL2, ALPL, RELA, DIXDC1, SIX3, HAND1, CSF1R, APBB1, ZNF423, PLCG1, HIC1, PKD2, PARD3, NTRK2, ERC1, 652 2349 15360 2.1261625492638823 1.3752977507117933E-25 1.5281086119019928E-26 5.00746825469533E-26 GOTERM_BP_ALL GO:0050896~response to stimulus 187 3.54% 4.631807729749107E-8 KIT, CXCL2, HSF1, DNAJC3, KCNJ8, HSPA5, IKBKG, MNDA, NFKBIA, VIPR1, POU2AF1, PER1, CRY1, STAT1, RALA, TNFRSF25, IRS2, PLG, PARP1, TNFRSF14, MAP2K7, PDC, HDAC5, PTX3, HMGB1, ERCC3, PPEF1, FYN, CTSS, RAG1, PRKCG, MAP3K7, PLAT, DEFB1, S100A7, ATP7B, PRKCD, DLG4, CCL8, HTR1A, WNT2, TGM2, DOCK2, PPARA, RFXANK, ARHGDIB, TTN, ARRB2, IL12A, CEBPE, EBI3, CACNA1B, IL4R, PARK2, FOS, CHEK1, CHAF1B, GNAI2, CSNK1E, ADRB2, CFTR, GTF2H1, RHO, NMI, VAV1, MCM7, GRM1, HLA-DRA, FGF7, MEFV, ASF1A, ITGB2, CCL13, GAB1, MAP3K5, MPZ, ERCC4, TP73, CCL17, BMI1, PTPN11, FGF2, PPEF2, MAPK14, GNA12, IL16, ERCC2, GJA1, CP, AGTR2, KCNV2, RELB, C1QBP, TUBB, CTSB, AKT1, TNNT2, CTGF, REN, MBD2, ARRB1, GJA8, ATR, FABP4, ATP2B2, SMAD3, SELE, TNFRSF1B, GADD45G, IL4, CRYAA, MAPK8, CD28, ASIP, BCL10, OPRD1, ABCB4, GNAQ, MAPK1, ETS1, IL27RA, CREBBP, ANKRD1, ATOX1, SH2D1A, MBL2, EGFR, WASL, PMP22, XPA, ZAP70, ACCN2, CASP3, MAP3K4, HSP90AA1, CCR1, FOSL1, IL8RA, VHL, TSHR, PRKAA1, CHAF1A, CD74, APP, NCF2, GUCY2C, CCR4, TRH, HIF1A, PTGS2, SAG, EP300, CCL7, PRKCA, CDC2, C1QA, KNG1, LIPE, WAS, CCR3, CD46, STAT3, EBI2, PAX5, INSIG2, CCL5, MIF, CHAT, FER, RAG2, TRAF6, TP53, NPHP1, RELA, SMAD7, PLAU, C5AR1, FANCA, RAC1, RAD52, HDAC4, APOH, PKD2, F11R, XAB2, TRPV1, VCP, 652 3066 15360 1.4368554380320075 2.4332557510231556E-4 2.5088131784256618E-6 8.860574488567252E-5 GOTERM_BP_ALL GO:0007269~neurotransmitter secretion 9 0.17% 3.2783176287253034E-4 CACNA1B, SNPH, SNAP25, PARK2, LIN7A, NLGN1, SNCAIP, PCLO, NRXN2, 652 42 15360 5.04820333041192 0.8214185496168107 0.0076953967379106425 0.6252769863670626 GOTERM_BP_ALL GO:0007268~synaptic transmission 35 0.66% 2.413063412646668E-7 CTNNB1, DTNA, SLC6A1, MAPK1, LIN7A, PHOX2A, NLGN1, SNCAIP, VIPR1, HAP1, SLC6A4, GRM1, NOS1, PLP1, MPZ, TH, CHAT, PCLO, PMP22, SNCB, NRXN2, DLG4, WNT2, UBB, DLG2, STX1A, KIF5A, SNPH, CACNA1B, GABARAPL2, SNAP25, PARK2, AKAP9, CAMK4, CFTR, 652 304 15360 2.7123022279625446 0.0012670203209613762 1.092945466840689E-5 4.6161437572411756E-4 GOTERM_BP_ALL GO:0007267~cell-cell signaling 69 1.31% 8.885080719636085E-12 ASIP, TXN, GNAQ, FGF8, MAPK1, LIN7A, GRB10, NOS1, VIPR1, HAP1, SH2D1A, TEK, FZD1, NR5A1, PMP22, GJA3, SNCB, DLG4, NRXN2, CCL8, WNT2, CCR1, TSHR, SNPH, CACNA1B, PARK2, LNPEP, AKAP9, TRH, CAMK4, AREG, CFTR, ADCYAP1, CTNNB1, VIPR2, DTNA, SLC6A1, CCL7, PHOX2A, C1QA, NLGN1, SNCAIP, SLC6A4, GRM1, FGF7, PLP1, ITGB2, CCL13, PCSK1, MPZ, SALL1, EFNA2, TH, CCL5, CCL17, FGF2, CHAT, PCLO, AR, FRS2, GJA1, UBB, DLG2, STX1A, KIF5A, FGF1, GABARAPL2, SNAP25, MLLT4, 652 661 15360 2.459185283498696 4.66823923961357E-8 8.04868838244488E-10 1.699709262226179E-8 GOTERM_BP_ALL GO:0016079~synaptic vesicle exocytosis 4 0.08% 0.005255204628673103 SNPH, SNAP25, NLGN1, PCLO, 652 9 15360 10.47034764826176 0.9999999999990513 0.08676867970869917 9.58828678206337 GOTERM_BP_ALL GO:0042176~regulation of protein catabolic process 6 0.11% 5.446959848620477E-4 GJA1, MDM2, RELA, MDM4, STUB1, PRKCG, 652 17 15360 8.314687838325515 0.9428806535091032 0.012005880664719859 1.0368661727136685 GOTERM_BP_ALL GO:0050880~regulation of blood vessel size 8 0.15% 0.0017593250816535133 WNT2, AGTR2, KCNJ8, CAV1, KNG1, NTS, ADRB2, CFTR, 652 42 15360 4.4872918492550395 0.999904045331765 0.034695402878536896 3.312423205285242 GOTERM_BP_ALL GO:0050877~neurological system process 72 1.36% 0.001790109701527287 OPRD1, GNAQ, MAPK1, LIN7A, VIPR1, HAP1, NOS1, CRY1, PDC, ERCC3, PPEF1, KIFC3, PMP22, GJA3, SNCB, DLG4, NRXN2, AXIN1, WNT2, NDN, ARRB2, SNPH, CACNA1B, APP, PARK2, MITF, AKAP9, CAMK4, SAG, EYA1, ADRB2, CFTR, GPR143, CTNNB1, DTNA, SLC6A1, PHOX2A, RHO, NLGN1, SNCAIP, SLC6A4, GRM1, PLP1, MPZ, TH, PTPN11, CHAT, PPEF2, PCLO, ERCC2, GJA1, OPRL1, AGTR2, UBB, DLG2, STX1A, KCNV2, KIF5A, ARRB1, GJA8, SIX3, GABARAPL2, SNAP25, PAX3, C5AR1, RAC3, ATP2B2, SIX1, PKD2, SOX10, CRYAA, TRPV1, 652 1185 15360 1.4313892987497088 0.9999183986403786 0.03502956998460549 3.3694474243409545 GOTERM_BP_ALL GO:0007254~JNK cascade 14 0.27% 3.877219541897434E-6 CARD9, MAP3K4, SH2D3C, EDA2R, PAK1, GAB1, MAP3K5, DAXX, PKN1, MAPK8, MAP3K7, CRKL, MAPK8IP3, MDFI, 652 67 15360 4.9226261331379915 0.020164864904754776 1.3489786049403207E-4 0.007416801732418321 GOTERM_BP_ALL GO:0050870~positive regulation of T cell activation 9 0.17% 5.353403067570907E-4 CD28, EBI3, TRAF6, BCL10, ZAP70, IL4, NCK1, MAP3K7, IL12A, 652 45 15360 4.711656441717792 0.9400012236088024 0.01185054088244697 1.0191433160081864 GOTERM_BP_ALL GO:0016070~RNA metabolic process 160 3.03% 0.0013349746696587202 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, HDAC5, ERCC3, TFCP2, HMGB1, SFRS2IP, RYBP, POU1F1, NOL3, PPARA, RFXANK, CEBPE, FOXH1, SRY, POU3F3, FOS, CHAF1B, HOXD4, SRPK1, TCF3, SMAD1, EYA1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, NMI, MCM7, ASCC2, ASF1A, ORC2L, GSPT2, TP73, BMI1, AR, FOXL2, ERCC2, CLIP1, HOXB9, RELB, RFXAP, APOBEC1, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, DACH1, SMAD3, TNFRSF1B, IL4, SREBF2, BCL10, ETS1, CALR, CREBBP, ANKRD1, MSC, MYF5, SMARCA4, U2AF2, PLAG1, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, ZBTB16, NDN, FOSL1, TAF13, VHL, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, BICD1, PAX5, NCOR1, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, MEIS1, TP53, MAPKAPK2, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, CUGBP2, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, COPS5, SOX10, XAB2, WT1, NCOA2, ERC1, 652 3020 15360 1.248120911713322 0.9991049605949133 0.02683734470128807 2.523116182705487 GOTERM_BP_ALL GO:0022403~cell cycle phase 29 0.55% 0.001271441375151913 CD28, CDC25A, PPP5C, KPNA2, CDC2, CALR, GSPT2, CDK3, MARK4, AKAP8, CDKN1C, CDKN3, PRM1, CLIP1, BUB1B, ANAPC10, TP53, CLASP2, FOSL1, RCC1, TTN, RB1, UBE2I, APBB1, CHEK1, MDM2, RAD52, CRYAA, NEDD9, 652 356 15360 1.9190735506996621 0.9987497394377151 0.025674021706994177 2.404417694648664 GOTERM_BP_ALL GO:0022402~cell cycle process 79 1.50% 1.1452519361487989E-13 CD28, CDC25A, PPP5C, KPNA2, BCL10, CDK5R2, RAP1A, FGF8, CDC37, CALR, CDK5R1, CDC14A, STAT1, HDAC5, CDK3, ERCC3, MARK4, AKAP8, EGFR, CDKN3, PRM1, AXIN1, ANAPC10, CASP3, APC2, CLASP2, NDN, FOSL1, VHL, TTN, RCC1, RB1, UBE2I, CHEK1, SRPK1, DUSP6, ADCYAP1, NEDD9, GTF2H1, CYLD, PRKCA, CDC2, MDM4, FGF7, IGF1R, RBL1, GSPT2, TP73, FRK, FGF2, PTPN11, CDKN1C, CLIP1, ERCC2, MYC, BUB1B, CDC45L, TP53, ZMYND11, TFDP2, E2F2, STARD13, FGF1, STK11, DAXX, APBB1, TSC2, ATR, MDM2, HIC1, RAD52, GADD45G, COPS5, PKD2, CRYAA, WT1, EPHB2, MAPK3, PLEKHO1, 652 749 15360 2.4847854398912252 6.019771348064751E-10 1.1803447108604814E-11 2.191802295214984E-10 GOTERM_BP_ALL GO:0050865~regulation of cell activation 14 0.27% 8.106149337542485E-5 CD28, BCL10, TRAF6, ZAP70, CASP3, NCK1, IL27RA, IL12A, CD74, EBI3, CD2, MIF, IL4, MAP3K7, 652 88 15360 3.7479085331846074 0.34682771545112556 0.0021817925719703757 0.15495551745243752 GOTERM_BP_ALL GO:0007249~I-kappaB kinase/NF-kappaB cascade 21 0.40% 1.2916398044242233E-6 PPM1A, PPP5C, GJA1, BCL10, TRAF6, TGM2, IKBKG, CARD9, OTUD7B, NFKBIA, RELA, MAP3K3, CASP8, STAT1, RHOA, RHOH, TRAF3IP2, MAP3K7, TICAM1, ERC1, TRAF5, 652 137 15360 3.611123550221665 0.006763305118242857 4.9174732298262747E-5 0.00247085850313411 GOTERM_BP_ALL GO:0007243~protein kinase cascade 68 1.29% 4.481949226661877E-23 KIT, PPP5C, FGFR1, BCL10, IKBKG, MAPK1, CAV3, SRC, NFKBIA, MARK1, EDA2R, STAT1, MAP2K7, FYN, RHOH, MAP3K7, CRKL, TICAM1, TRAF5, PLCE1, PPM1A, ZAP70, TGM2, MAP3K4, DUSP22, OTUD7B, PRKAA1, IL12A, SH2D3C, SRPK1, SMAD1, TRAF3IP2, MAPK8IP3, DUSP6, MDFI, ADRB2, PRKCA, NMI, GRM1, MAP3K3, PAK1, STAT3, GAB1, CASP8, MAP3K5, FGF2, PTPN11, MAP3K7IP1, MAPK14, GNA12, FRS2, TRAF6, GJA1, CARD9, MAPKAPK2, AKT1, RELA, REN, DAXX, RHOA, PKN1, C5AR1, CAV1, GADD45G, PKD2, IL4, MAPK8, ERC1, 652 393 15360 4.076242214208776 2.35481612368815E-19 1.1213410112800715E-20 8.573901163519158E-20 GOTERM_BP_ALL GO:0050863~regulation of T cell activation 10 0.19% 0.0014282695713751475 CD28, EBI3, TRAF6, BCL10, ZAP70, CD2, IL4, NCK1, MAP3K7, IL12A, 652 64 15360 3.6809815950920246 0.9994521408859637 0.028577881030137142 2.697169983047798 GOTERM_BP_ALL GO:0007242~intracellular signaling cascade 155 2.94% 9.415311396500641E-27 KIT, PPP5C, RAP1A, IKBKG, HSPA5, CAV3, SRC, GZMB, VIPR1, NFKBIA, JAK1, PLCD1, STAT1, RALA, MAP2K7, TAX1BP3, FYN, PRKCG, YWHAE, MAP3K7, TICAM1, PRKCD, PLCE1, ABL2, TGM2, PRKD3, SNX19, DUSP22, OTUD7B, DFFA, ARHGDIB, BMX, RGS19, IL12A, GNAI3, S100A1, CHN1, SRPK1, GNAI2, SMAD1, TRAF3IP2, GNB2L1, MAPK8IP3, DUSP6, ADRB2, NMI, VAV1, GRM1, MAP3K3, GAB1, MAP3K5, SOS1, FRK, FGF2, PTPN11, MAP3K7IP1, MAPK14, FOXL2, CASP2, GNA12, MCF2, ARHGEF9, FRS2, GJA1, AKT1, CTGF, REN, PICK1, RHOA, TSC2, RAC3, CAV1, SMAD3, GADD45G, IL4, MAPK8, RAB33B, TNK2, ASIP, FGFR1, BCL10, OPRD1, IQGAP2, GNAQ, MAPK1, GRB10, MARK1, PSEN1, INADL, EDA2R, RAB6A, SH2D1A, GRB7, RHOH, EGFR, RND1, CRKL, TRAF5, BCR, PPM1A, BAD, ZAP70, CASP3, MAP3K4, ZBTB33, PIK3R1, CCR1, TSHR, PRKAA1, SH2D3C, RB1, GUCY2C, TRH, RAF1, MDFI, ARHGEF7, ADCYAP1, FES, CTNNB1, PRKCA, BCL2L1, LIMK1, RASA2, CCR3, PRKAR2A, SLA, PAK1, CASP8, STAT3, DFFB, FER, BUB1B, SMAD2, TRAF6, OPRL1, HCK, CARD9, TP53, MAPKAPK2, RELA, NCK1, GIT1, GMIP, IQGAP1, DAXX, PKN1, PLCG1, C5AR1, RAC1, TGFB1I1, PKD2, PARD3, VCP, NCOA2, ERC1, 652 1496 15360 2.4408648010235883 4.946804607721437E-23 3.805234313631875E-24 1.8011348468013798E-23 GOTERM_BP_ALL GO:0009653~anatomical structure morphogenesis 104 1.97% 6.679793185040009E-14 KCNJ8, FGF8, LLGL1, BAI1, PLG, ERCC3, FYN, WNT1, MAP3K7, S100A7, PLCE1, WNT2, TGM2, POU1F1, CLASP2, DAG1, BRSK2, IGFBP3, NTS, EYA1, GCM1, CLTCL1, NEDD9, CFTR, ADRB2, NOV, ITGB2, TP73, FGF2, PTPN11, MAP3K7IP1, AR, FOXL2, MCF2, GNA12, ERCC2, FRS2, GJA1, AGTR2, UBB, JUN, AKT1, CTGF, PTPRZ1, FGF1, PAX3, ATP2B2, CAV1, RAC3, SMAD3, BCL10, FGFR1, GNAQ, MAPK1, DCN, CDK5R1, MYF5, FZD1, CRKL, SMAD4, RNF2, NOTCH4, NDN, ZBTB16, VHL, CSPG4, RB1, EP300, CD44, CTNNB1, LIMK1, KNG1, DLX5, PITX2, IGF1R, BMPR1A, PARD6B, TWIST1, CASP8, SALL1, TH, PAX5, BICD1, SFRP1, CHAT, SIAH1, SMAD2, PRKG1, TP53, PKD1, ACTC1, RELA, NCK1, ZEB2, HAND1, HAND2, APBB1, SIX1, POU3F2, RAC1, PKD2, SOX10, F11R, PARD3, 652 1133 15360 2.162454854098192 3.5115332863711046E-10 7.166378601652923E-12 1.2785328351583303E-10 GOTERM_BP_ALL GO:0022008~neurogenesis 39 0.74% 4.5899485284054254E-9 GNAQ, LIMK1, DLX5, NLGN1, BAI1, PSEN1, PARD6B, TWIST1, CDK5R1, SMARCA4, FYN, FGF2, PTPN11, HOXC8, CHAT, CDKN1C, RND1, SIAH1, MCF2, FRS2, PRKG1, GJA1, WNT2, UBB, NDN, EPHA2, PTPRZ1, GATA2, APP, PICK1, APBB1, SIX1, CCR4, ATP2B2, POU3F2, BRSK2, PARD3, GCM1, CFTR, 652 312 15360 2.9447852760736195 2.411529886592323E-5 3.131894268371127E-7 8.780501836724852E-6 GOTERM_BP_ALL GO:0045055~regulated secretory pathway 9 0.17% 0.0018495367288328948 CACNA1B, SNPH, SNAP25, PARK2, LIN7A, NLGN1, SNCAIP, PCLO, NRXN2, 652 54 15360 3.9263803680981595 0.999940317008297 0.03603822317281047 3.4794375714706116 GOTERM_BP_ALL GO:0000902~cell morphogenesis 42 0.80% 3.980394864631015E-5 CTNNB1, FGFR1, LIMK1, DLX5, LLGL1, BAI1, NOV, PARD6B, ITGB2, CDK5R1, TP73, FYN, WNT1, PTPN11, CHAT, SIAH1, AR, GNA12, MCF2, SMAD4, PLCE1, PRKG1, GJA1, UBB, TP53, CLASP2, NDN, NCK1, VHL, CTGF, PTPRZ1, RB1, APBB1, RAC3, ATP2B2, POU3F2, RAC1, SMAD3, BRSK2, IGFBP3, PARD3, NEDD9, 652 499 15360 1.982861428378229 0.18871357197488603 0.0010943437445688486 0.07611688431170549 GOTERM_BP_ALL GO:0016055~Wnt receptor signaling pathway 19 0.36% 5.948117444562068E-6 AXIN1, CTNNB1, WNT2, APC2, SLC9A3R1, ZBTB33, DIXDC1, SIX3, LRP1, CSNK1A1, CSNK2A1, TAX1BP3, FZD1, MARK4, TGFB1I1, WNT1, SFRP1, MDFI, CTNND1, 652 126 15360 3.552439380660239 0.0307682213087066 2.0160226906473788E-4 0.011378045307830487 GOTERM_BP_ALL GO:0046649~lymphocyte activation 27 0.51% 7.456300271528375E-8 CD28, BCL10, WAS, VAV1, IL27RA, TNFRSF14, HDAC5, RHOH, RAG1, MAP3K7, PRKCD, NTRK1, RAG2, TRAF6, ZAP70, CASP3, RELB, PIK3R1, NCK1, IL12A, CD74, EBI3, CD2, SMAD3, HDAC4, IL4, TCF3, 652 185 15360 3.4382357817940634 3.9167730499567455E-4 3.730983807348487E-6 1.426378012814311E-4 GOTERM_BP_ALL GO:0042127~regulation of cell proliferation 59 1.12% 2.426774948737094E-12 CD28, KIT, HSF1, FGFR1, VIPR1, BAI1, NFKBIA, ETS1, PLG, IRS2, MARK4, EGFR, CDKN3, PMP22, SMAD4, TRAF5, DBP, HTR1A, WNT2, TGM2, CASP3, POU1F1, NDN, ZBTB16, FOSL1, VHL, TSHR, IL12A, RB1, EBI3, CHEK1, PTGS2, SMAD1, CFTR, ADRB2, CTNNB1, MDM4, FGF7, IGF1R, BMPR1A, CTBP1, FGF2, BMI1, FRK, CDKN1C, MYC, LAMA1, GJA1, TP53, NCK1, LIFR, MDM2, CAV1, POU3F2, SMAD3, TGFB1I1, HDAC4, IL4, TGFBR1, 652 499 15360 2.7854481970075122 1.2750015598861353E-8 2.3181845332231887E-10 4.6422865551676296E-9 GOTERM_BP_ALL GO:0016044~membrane organization and biogenesis 28 0.53% 1.4674493075749623E-4 SERPINA5, BCL2L1, CAV3, VAV1, NLGN1, SYP, SNX17, RABEP1, PTX3, EGFR, ATG7, SNAP91, SYNJ1, TP53, SH3GL2, SH3GL3, CEBPE, GATA2, CUBN, APP, LRP1, PICK1, LRP2, CD2, TSC2, RAC1, CLTCL1, ADRB2, 652 295 15360 2.2360403452220026 0.5374748946888483 0.0037001300939385473 0.280347724670571 GOTERM_BP_ALL GO:0016043~cellular component organization and biogenesis 208 3.94% 2.1169491249475666E-19 TUBA3C, GZMB, LLGL1, BAI1, HAP1, NFKBIA, CDC37, KIF1C, STAT1, FHOD1, STXBP1, HMGB1, PTX3, FYN, PRM1, ATG7, PLCE1, ABL2, EXOC2, POU1F1, DOCK2, SLC9A3R1, DFFA, RCC1, CACNA1B, CLTCL1, NEDD9, VAV1, NLGN1, ITGB2, HIST3H3, MPZ, FMNL1, TRPV6, PTPN11, FOXL2, GJA1, UBB, TUBB, E2F2, MBD2, PTPRZ1, CUBN, PICK1, GTF2F2, TSC2, CD2, ATP2B2, CAV1, WRN, ACTN1, TGFBR1, SLC9A3R2, BCL10, KPNA2, CDK5R1, RAB6A, SMARCA4, CBX5, WASL, NRXN2, CBX2, RNF2, MPP6, HSP90AA1, SH3GL3, TAF13, CD74, RB1, APP, RAF1, EP300, MDFI, MAGI1, WAS, DLX5, MDM4, IGF1R, PEX6, HDAC6, ERC2, CHAT, DFFB, SIAH1, PRKG1, SETDB1, ACTC1, TRAF1, PEX19, GATA2, TLN1, SHANK1, CUGBP2, MDM2, FANCA, POU3F2, RAC1, HDAC4, MICAL1, PEX26, CAV3, SRC, SYP, SNX17, HDAC5, MARK4, WNT1, AKAP8, SFRS2IP, ATP7B, DLG4, CCL8, WNT2, TGM2, CLASP2, PTK2, TTN, ARHGDIB, CEBPE, EIF5A, SNPH, DAG1, LRP1, PARK2, CHAF1B, BRSK2, CAMK4, IGFBP3, ETF1, CFTR, ADRB2, GFAP, SNCAIP, NOV, ASF1A, TJP1, ERCC4, ATG12, TP73, BMI1, AR, SYNPO, ABLIM3, MCF2, GNA12, AP2B1, ATG5, TNNT2, AKT1, CTGF, HDAC1, SNAP25, GABARAPL2, RHOA, TUBA4A, SGCG, RAC3, SMAD3, KIFAP3, CRYAA, TNK2, FGFR1, LIN7A, MARK1, CALR, CREBBP, PDE4DIP, MYF5, KIFC3, EGFR, RND1, SMAD4, CASP3, APC2, NDN, VHL, VIM, CHAF1A, LRP2, TBP, SERPINA5, CTNNB1, LIMK1, BCL2L1, RPH3A, RBL1, PARD6B, PAK1, RABEP1, NCOR1, CCL5, WIPF1, PCLO, EXOC3, BUB1B, SNAP91, SYNJ1, STX1A, TP53, NPHP1, SH3GL2, NCK1, KIF5A, YWHAZ, APBB1, PARD3, VCP, ERC1, 652 2723 15360 1.7995309215521496 1.1122450702474514E-15 3.972303822312327E-17 4.049691696087591E-16 GOTERM_BP_ALL GO:0042113~B cell activation 11 0.21% 6.193032982769633E-4 RAG2, HDAC5, CASP3, HDAC4, PIK3R1, TCF3, IL4, RAG1, IL27RA, NTRK1, PRKCD, 652 69 15360 3.7556681781808483 0.9614125234131955 0.013414718086971478 1.1780903822354638 GOTERM_BP_ALL GO:0042110~T cell activation 18 0.34% 8.525623738491075E-6 CD28, RAG2, BCL10, TRAF6, ZAP70, RELB, VAV1, WAS, NCK1, IL12A, CD74, EBI3, CD2, TNFRSF14, SMAD3, RHOH, IL4, MAP3K7, 652 117 15360 3.624351109013686 0.04380538843960846 2.781837722027891E-4 0.016308129022812867 GOTERM_BP_ALL GO:0009628~response to abiotic stimulus 21 0.40% 3.2239107795943694E-5 KIT, GJA1, ACCN2, KCNJ8, RHO, NPHP1, AKT1, RELA, IL12A, MPZ, PDC, ERCC4, ATP2B2, ERCC3, PKD2, MAPK8, SAG, TRPV1, PMP22, ERCC2, ADRB2, 652 169 15360 2.9273605111264382 0.1558178607055054 9.201579318656172E-4 0.06165490589814526 GOTERM_BP_ALL GO:0050821~protein stabilization 5 0.09% 0.003002231728474656 APBB1, MDM4, VHL, PRKCD, PEX6, 652 15 15360 7.852760736196319 0.9999998621984444 0.054106057873499314 5.58956935486451 GOTERM_BP_ALL GO:0050808~synapse organization and biogenesis 8 0.15% 0.0026520961394488453 APP, CTNNB1, CUGBP2, UBB, ERC2, NLGN1, CHAT, NRXN2, 652 45 15360 4.188139059304704 0.9999991281279493 0.04947119410760681 4.953276946563001 GOTERM_BP_ALL GO:0009611~response to wounding 45 0.85% 6.175134312113345E-8 CXCL2, CCL7, GNAQ, PRKCA, C1QA, NMI, KNG1, WAS, CCR3, FGF7, MEFV, CD46, ITGB2, STAT3, CCL13, PLG, HDAC5, PTX3, CCL5, MBL2, CCL17, MIF, PLAT, GNA12, CCL8, TGM2, CASP3, CTSB, CCR1, AKT1, RELA, IL8RA, CTGF, FOS, PLAU, FABP4, CCR4, RAC1, SELE, HDAC4, TNFRSF1B, PTGS2, APOH, F11R, ADRB2, 652 431 15360 2.4596814370916547 3.243889414538126E-4 3.244410406111342E-6 1.1812932046995073E-4 GOTERM_BP_ALL GO:0032147~activation of protein kinase activity 13 0.25% 9.366502863277297E-6 TRAF6, IKBKG, PRKD3, MAP3K4, GRM1, PICK1, FGF2, GADD45G, MAP3K7IP1, GNB2L1, MAP3K7, PARD3, PLCE1, 652 62 15360 4.939639817929942 0.04802055567134389 3.0373063312416626E-4 0.017916457207367564 GOTERM_BP_ALL GO:0065009~regulation of a molecular function 69 1.31% 1.8128083126637433E-15 CDC25A, KIT, BCL10, CDK5R2, GNAQ, IKBKG, HSPA5, CAV3, NFKBIA, CDC37, PSEN1, CDK5R1, EDA2R, STAT1, EGFR, CDKN3, MAP3K7, SMAD4, PLCE1, ABL2, CASP3, MAP3K4, PRKD3, SLC9A3R1, DUSP22, PRKAA1, GNAI3, RB1, CHEK1, CAMK2A, GNAI2, GNB2L1, EP300, MDFI, DUSP6, ADRB2, ADCYAP1, GTF2H1, PRKCA, VAV1, GRM1, RBL1, GAB1, MAP3K5, FGF2, PTPN11, MAP3K7IP1, CDKN1C, FOXL2, FRS2, SMAD2, TRAF6, TP53, CTSB, TNNT2, RELA, GIT1, DAXX, PICK1, TSC2, PKN1, C5AR1, FABP4, CAV1, SMAD3, GADD45G, PARD3, VCP, ERC1, 652 554 15360 2.9341542822971807 9.332978834208916E-12 2.2226664952995634E-13 3.397282455352979E-12 GOTERM_BP_ALL GO:0065008~regulation of biological quality 87 1.65% 2.1949454753270265E-13 FGFR1, BCL10, TXN, KCNJ8, GNAQ, IKBKG, CAV3, CALR, CREBBP, SLC9A1, ATOX1, PLG, PLAT, SMAD4, ATP7B, PRKCD, PLCE1, WNT2, TGM2, CASP3, SLC9A3R1, CCR1, NDN, VHL, SLC22A2, RB1, CACNA1B, APP, SLC34A1, CCR4, CHGA, HIF1A, PTGS2, SMAD1, IGFBP3, NTS, EP300, ADRB2, CFTR, NEDD9, CTNNB1, CCL7, PRKCA, BCL2L1, KNG1, WAS, CCR3, MDM4, NOV, PLP1, PEX6, CSRP3, CCL13, MPZ, TP73, CCL5, NFE2, SLC2A4, AR, GNA12, MYC, RYR2, CP, OPRL1, AGTR2, UBB, TP53, MAPKAPK2, AKT1, NCK1, CTGF, REN, IREB2, CUBN, APBB1, PLAU, C5AR1, FABP4, ATP2B2, CAV1, CACNA1C, SMAD3, TNFRSF1B, PLN, APOH, PKD2, TRPV1, 652 881 15360 2.3264137935836997 1.1532061972019392E-9 2.217703798379489E-11 4.198863479132342E-10 GOTERM_BP_ALL GO:0050801~ion homeostasis 29 0.55% 8.560532257066478E-7 CCL7, BCL2L1, PRKCA, CAV3, KNG1, CCR3, CALR, SLC9A1, CSRP3, CCL13, ATOX1, CCL5, ATP7B, MYC, PLCE1, RYR2, CP, OPRL1, TGM2, SLC9A3R1, CCR1, IREB2, APP, C5AR1, CACNA1C, ATP2B2, CCR4, PLN, PKD2, 652 236 15360 2.8948736612249144 0.004487606042765213 3.4072946573870944E-5 0.0016376041808596753 GOTERM_BP_ALL GO:0065007~biological regulation 396 7.50% 1.2438917993738212E-45 KIT, PPP5C, KCNJ8, HSPA5, NFKBIA, BAI1, CDC37, CRY1, TNFRSF25, IRS2, CDK3, TFCP2, HMGB1, PTX3, FYN, PRKCG, ATG7, TICAM1, PLCE1, ABL2, PRKD3, DUSP22, RFXANK, RCC1, SLC34A1, NTS, GCM1, GTF2H1, CYLD, MAX, RGS2, VAV1, ITGB2, MAP3K5, MPZ, CTBP1, TRPV6, CLIP1, HOXB9, CP, UBB, RELB, TUBB, E2F2, ATF7IP2, CTSB, JUN, ARRB1, FGF1, HOXB7, PICK1, TSC2, PAX3, CD2, ATP2B2, CAV1, CACNA1C, ACTN1, STUB1, TGFBR1, CDC25A, BCL10, IL27RA, EDA2R, SMARCA4, NR5A1, PMP22, SNCB, CBX2, RNF2, PPM1A, ANAPC10, HSP90AA1, FOSL1, TAF13, RB1, PAK7, CHGA, EP300, BAG4, WAS, KNG1, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, TH, MIF, CDKN1C, CHAT, PRKG1, OPRL1, SETDB1, ACTC1, ZEB2, GATA2, DAXX, CUGBP2, TGFB1I1, APOH, IKBKG, CAV3, VIPR1, CDC14A, SNX17, PLG, ERCC3, RYBP, CDKN3, MAP3K7, ATP7B, HTR1A, CLASP2, CEBPE, GNAI3, SNPH, FOS, SMAD1, IGFBP3, DUSP6, EYA1, ETF1, ASCC2, PLP1, CSRP3, ORC2L, ERCC4, FGF2, AR, CASP2, IL16, MCF2, ERCC2, ARHGEF9, HDAC1, RHOA, DACH1, SMAD3, MAPK8, EPHB2, IQGAP2, GNAQ, LIN7A, CALR, PSEN1, FZD1, RHOH, PLAG1, EGFR, KCNJ12, BCR, TRAF5, SEPT4, ZAP70, CASP3, NDN, PIK3R1, TSHR, TRAIP, MYOG, TBP, HIF1A, CAMK2A, ASCC3, LIMK1, BCL2L1, CCR3, MYOD1, RBL1, CASP6, NCOR1, MIZF, MLLT1, TRAF6, CDC45L, MAPKAPK2, RGS14, STARD13, RELA, SIX3, HAND1, STK11, PLAU, ZNF423, PARD3, NCOA2, HSF1, CDK5R2, MAFK, FGF8, MNDA, GATA4, POU2AF1, STAT1, PLAT, PRKCD, POU1F1, SLC9A3R1, OTUD7B, ADRBK1, FOXH1, CACNA1B, EBI3, SRY, POU3F3, CHEK1, SRPK1, GNB2L1, CASP5, NEDD9, PHOX2A, SERPINB2, MCM7, NLGN1, SLC6A4, GRM1, MAP3K3, GAB1, CCL13, SOS1, PTPN11, FOXL2, LAMA1, GJA1, AGTR2, ZNF208, MBD2, CUBN, GTF2F2, GADD45G, TNFRSF1B, WRN, IL4, SREBF2, PLEKHO1, KPNA2, TXN, MAPK1, SLC9A1, CDK5R1, HOXC8, WASL, NRXN2, DBP, TCEA2, CCR1, ZBTB16, CD74, APP, CCR4, PTGS2, MDFI, LMO2, ADCYAP1, CTNND1, CCL7, C1QA, CDC2, RASA2, PEX6, SCN5A, CASP8, SALL1, CHRM3, HDAC6, PAX5, SFRP1, SMAD2, CARD9, TRAF1, IQGAP1, SMAD7, HAND2, MDM2, SIX1, POU3F2, RAC1, HDAC4, PLN, SOX10, TRPV1, WT1, RAP1A, PER1, MEOX1, MEOX2, YBX1, HDAC5, TAX1BP3, MARK4, LAMA3, AXIN1, WNT2, TGM2, PPARA, NOL3, ARHGDIB, IL12A, RGS19, EIF5A, LRP1, S100A1, PARK2, HOXD4, CHAF1B, TRAF3, TCF3, GNAI2, TRAF3IP2, MAPK8IP3, CFTR, ADRB2, SNCAIP, FGF7, NOV, ASF1A, TP73, BMI1, FRK, MAP3K7IP1, GNA12, FRS2, TNNT2, AKT1, REN, CTGF, LIFR, IREB2, SNAP25, ATR, FABP4, CRYAA, MAPK3, CD28, TNK2, FGFR1, NAIP, ETS1, CREBBP, MSC, ANKRD1, ATOX1, MYF5, MBL2, TRIP4, RND1, HEYL, SMAD4, NOTCH4, BAD, APC2, MAP3K4, ZBTB33, VHL, PRKAA1, SLC22A2, CHAF1A, HOXA9, EAF2, MITF, NHLH1, HOXB6, MYT1, ARHGEF7, SERPINA5, CTNNB1, PRKCA, CD46, PARD6B, CCL5, NFE2, PCLO, SLC2A4, MYC, BUB1B, RYR2, STX1A, TP53, MEIS1, TFDP2, ZMYND11, NCK1, GIT1, YWHAZ, APBB1, PKN1, ASCC1, C5AR1, HIC1, COPS5, PKD2, VCP, ERC1, 652 5238 15360 1.7810385174878252 6.535407513910056E-42 6.535407513910056E-42 2.3795462212066068E-42 GOTERM_BP_ALL GO:0009605~response to external stimulus 68 1.29% 7.660705828647755E-12 CXCL2, GNAQ, MAPK1, PER1, RALA, PLG, HDAC5, PDC, PTX3, MBL2, PMP22, PLAT, DEFB1, CCL8, TGM2, CASP3, DOCK2, CCR1, FOSL1, IL8RA, PARK2, FOS, CCR4, PTGS2, GNAI2, SAG, ADRB2, CCL7, PRKCA, RHO, C1QA, NMI, WAS, KNG1, CCR3, FGF7, MEFV, CD46, ITGB2, STAT3, CCL13, MPZ, CCL5, CCL17, FGF2, MIF, MAPK14, FER, GNA12, IL16, CP, TP53, CTSB, AKT1, RELA, CTGF, PLAU, C5AR1, FABP4, ATP2B2, SELE, RAC1, TNFRSF1B, HDAC4, APOH, PKD2, IL4, F11R, 652 644 15360 2.48752048165225 4.024963706772411E-8 7.061340401293137E-10 1.4654921720591574E-8 GOTERM_BP_ALL GO:0065003~macromolecular complex assembly 51 0.97% 5.156565080249672E-7 BCL10, LIN7A, SRC, LLGL1, CREBBP, HMGB1, SFRS2IP, WASL, SMAD4, DLG4, MPP6, TGM2, APC2, SLC9A3R1, PTK2, TAF13, CD74, EIF5A, CHAF1A, DAG1, CHAF1B, TBP, CLTCL1, MAGI1, ADRB2, WAS, MDM4, IGF1R, ASF1A, PARD6B, HIST3H3, TJP1, WIPF1, GJA1, AP2B1, TP53, E2F2, TRAF1, NCK1, MBD2, TLN1, GTF2F2, PICK1, MDM2, CAV1, FANCA, SMAD3, KIFAP3, TGFBR1, SLC9A3R2, PARD3, 652 560 15360 2.145486415425066 0.0027055932590858145 2.1848632216880937E-5 9.864384990732056E-4 GOTERM_BP_ALL GO:0050794~regulation of cellular process 316 5.99% 1.841145885812264E-27 KIT, HSF1, PPP5C, MAFK, CDK5R2, HSPA5, FGF8, MNDA, GATA4, BAI1, NFKBIA, CDC37, POU2AF1, CRY1, STAT1, IRS2, TNFRSF25, CDK3, HMGB1, TFCP2, PTX3, PRKCG, TICAM1, PLCE1, POU1F1, OTUD7B, RFXANK, RCC1, ADRBK1, FOXH1, EBI3, SRY, POU3F3, CHEK1, SRPK1, CASP5, GCM1, NEDD9, GTF2H1, CYLD, MAX, PHOX2A, RGS2, VAV1, SERPINB2, MCM7, NLGN1, GRM1, MAP3K3, ITGB2, GAB1, MAP3K5, CTBP1, TRPV6, SOS1, PTPN11, FOXL2, CLIP1, HOXB9, LAMA1, GJA1, UBB, RELB, ATF7IP2, E2F2, TUBB, JUN, CTSB, ZNF208, ARRB1, MBD2, FGF1, HOXB7, GTF2F2, TSC2, PAX3, CD2, CAV1, GADD45G, TNFRSF1B, WRN, ACTN1, IL4, STUB1, TGFBR1, SREBF2, PLEKHO1, CDC25A, BCL10, KPNA2, MAPK1, CDK5R1, EDA2R, SMARCA4, HOXC8, WASL, NR5A1, PMP22, PPM1A, RNF2, CBX2, DBP, ANAPC10, TCEA2, ZBTB16, FOSL1, TAF13, CD74, RB1, APP, PAK7, PTGS2, EP300, MDFI, BAG4, LMO2, CTNND1, ADCYAP1, CDC2, RASA2, KNG1, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, CASP8, STAT3, SALL1, HDAC6, PAX5, MIF, SFRP1, CDKN1C, SMAD2, SETDB1, CARD9, TRAF1, ZEB2, GATA2, HAND2, SMAD7, IQGAP1, DAXX, MDM2, SIX1, POU3F2, RAC1, TGFB1I1, HDAC4, PLN, SOX10, WT1, RAP1A, IKBKG, CAV3, VIPR1, PER1, MEOX1, CDC14A, MEOX2, SNX17, YBX1, PLG, TAX1BP3, HDAC5, ERCC3, MARK4, RYBP, CDKN3, MAP3K7, LAMA3, AXIN1, HTR1A, WNT2, TGM2, CLASP2, NOL3, PPARA, ARHGDIB, RGS19, IL12A, CEBPE, EIF5A, LRP1, FOS, CHAF1B, HOXD4, TRAF3, TCF3, SMAD1, TRAF3IP2, IGFBP3, MAPK8IP3, DUSP6, EYA1, ETF1, ADRB2, CFTR, ASCC2, FGF7, NOV, ASF1A, ORC2L, ERCC4, TP73, FRK, BMI1, FGF2, AR, CASP2, MCF2, ERCC2, ARHGEF9, AKT1, LIFR, CTGF, REN, HDAC1, RHOA, ATR, DACH1, FABP4, SMAD3, CRYAA, MAPK8, EPHB2, MAPK3, TNK2, CD28, FGFR1, NAIP, GNAQ, IQGAP2, ETS1, CALR, PSEN1, CREBBP, ANKRD1, MSC, MYF5, FZD1, PLAG1, RHOH, TRIP4, EGFR, RND1, HEYL, SMAD4, TRAF5, BCR, NOTCH4, SEPT4, BAD, CASP3, APC2, ZBTB33, PIK3R1, NDN, VHL, TSHR, PRKAA1, CHAF1A, HOXA9, EAF2, TRAIP, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, ARHGEF7, SERPINA5, CTNNB1, ASCC3, PRKCA, BCL2L1, MYOD1, CASP6, RBL1, PARD6B, NCOR1, NFE2, MYC, MIZF, BUB1B, TRAF6, MLLT1, CDC45L, MEIS1, TP53, MAPKAPK2, ZMYND11, TFDP2, RGS14, STARD13, RELA, NCK1, GIT1, HAND1, SIX3, STK11, YWHAZ, APBB1, ZNF423, ASCC1, HIC1, COPS5, PKD2, VCP, NCOA2, ERC1, 652 4422 15360 1.683495517393512 9.673380484057635E-24 8.793982258234213E-25 3.522084266075327E-24 GOTERM_BP_ALL GO:0050793~regulation of developmental process 26 0.49% 1.1118224541343654E-4 CTNNB1, GNAQ, LIMK1, MAPK1, NLGN1, DLX5, NFKBIA, ETS1, TWIST1, ITGB2, CDK5R1, FYN, FGF2, GNA12, LAMA3, NOTCH4, LAMA1, ZBTB16, VHL, RB1, SIX1, POU3F2, IL4, IGFBP3, LMO2, ADRB2, 652 259 15360 2.364924082715494 0.442439350624782 0.002902168570204644 0.21247573050040547 GOTERM_BP_ALL GO:0050790~regulation of catalytic activity 60 1.14% 2.855741624180819E-13 CDC25A, KIT, CDK5R2, GNAQ, IKBKG, HSPA5, CAV3, CDC37, PSEN1, CDK5R1, STAT1, EGFR, CDKN3, MAP3K7, PLCE1, ABL2, CASP3, MAP3K4, PRKD3, SLC9A3R1, DUSP22, PRKAA1, GNAI3, RB1, CHEK1, GNAI2, GNB2L1, DUSP6, MDFI, ADCYAP1, ADRB2, GTF2H1, PRKCA, VAV1, GRM1, RBL1, GAB1, MAP3K5, FGF2, PTPN11, CDKN1C, MAP3K7IP1, FOXL2, FRS2, TRAF6, TP53, CTSB, TNNT2, GIT1, DAXX, PICK1, TSC2, PKN1, C5AR1, FABP4, CAV1, SMAD3, GADD45G, PARD3, VCP, 652 488 15360 2.8965101076133966 1.5002763475990832E-9 2.830713441426269E-11 5.462519325760695E-10 GOTERM_BP_ALL GO:0007179~transforming growth factor beta receptor signaling pathway 12 0.23% 7.375691668563623E-6 SMAD2, FOXH1, SMAD3, MAP3K7IP1, CDKN1C, SMAD1, TGFBR1, STUB1, MAP3K7, BMPR1A, SMAD4, SMAD7, 652 51 15360 5.543125225550344 0.03801077301376621 2.4217084027045033E-4 0.014108643411681054 GOTERM_BP_ALL GO:0050789~regulation of biological process 354 6.71% 1.802239773950855E-36 KIT, HSF1, PPP5C, MAFK, CDK5R2, HSPA5, FGF8, MNDA, GATA4, BAI1, NFKBIA, CDC37, POU2AF1, CRY1, STAT1, IRS2, TNFRSF25, CDK3, HMGB1, TFCP2, PTX3, FYN, PRKCG, ATG7, TICAM1, PLCE1, POU1F1, OTUD7B, RFXANK, RCC1, ADRBK1, FOXH1, CACNA1B, EBI3, SRY, POU3F3, CHEK1, SRPK1, CASP5, GCM1, NEDD9, GTF2H1, CYLD, MAX, PHOX2A, SERPINB2, VAV1, RGS2, NLGN1, MCM7, GRM1, SLC6A4, MAP3K3, ITGB2, GAB1, MAP3K5, CTBP1, SOS1, TRPV6, PTPN11, FOXL2, CLIP1, HOXB9, LAMA1, GJA1, UBB, RELB, ATF7IP2, E2F2, TUBB, JUN, CTSB, ZNF208, MBD2, ARRB1, FGF1, HOXB7, GTF2F2, PICK1, TSC2, PAX3, CD2, CAV1, CACNA1C, WRN, TNFRSF1B, GADD45G, ACTN1, IL4, TGFBR1, STUB1, SREBF2, PLEKHO1, CDC25A, KPNA2, BCL10, MAPK1, IL27RA, CDK5R1, EDA2R, SMARCA4, HOXC8, WASL, NR5A1, PMP22, SNCB, NRXN2, PPM1A, RNF2, CBX2, DBP, ANAPC10, TCEA2, HSP90AA1, ZBTB16, FOSL1, TAF13, CD74, RB1, APP, PAK7, PTGS2, EP300, MDFI, BAG4, LMO2, CTNND1, ADCYAP1, CDC2, C1QA, RASA2, KNG1, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, CASP8, SCN5A, STAT3, SALL1, CHRM3, HDAC6, TH, PAX5, MIF, SFRP1, CHAT, CDKN1C, SMAD2, PRKG1, SETDB1, CARD9, ACTC1, TRAF1, ZEB2, GATA2, HAND2, SMAD7, IQGAP1, DAXX, CUGBP2, MDM2, SIX1, POU3F2, RAC1, TGFB1I1, HDAC4, PLN, APOH, SOX10, WT1, RAP1A, IKBKG, CAV3, VIPR1, PER1, MEOX1, CDC14A, MEOX2, SNX17, YBX1, PLG, TAX1BP3, HDAC5, ERCC3, MARK4, RYBP, CDKN3, MAP3K7, LAMA3, AXIN1, HTR1A, WNT2, TGM2, CLASP2, NOL3, PPARA, ARHGDIB, RGS19, IL12A, CEBPE, EIF5A, SNPH, S100A1, LRP1, PARK2, FOS, CHAF1B, HOXD4, TRAF3, TCF3, SMAD1, TRAF3IP2, IGFBP3, MAPK8IP3, EYA1, DUSP6, ETF1, ADRB2, CFTR, SNCAIP, ASCC2, FGF7, NOV, ASF1A, CSRP3, ORC2L, ERCC4, TP73, FRK, BMI1, FGF2, AR, CASP2, GNA12, MCF2, IL16, ERCC2, ARHGEF9, AKT1, TNNT2, LIFR, CTGF, REN, HDAC1, SNAP25, RHOA, ATR, DACH1, FABP4, SMAD3, CRYAA, MAPK8, EPHB2, MAPK3, TNK2, CD28, FGFR1, NAIP, GNAQ, IQGAP2, LIN7A, ETS1, CALR, PSEN1, CREBBP, ANKRD1, MSC, MYF5, FZD1, MBL2, PLAG1, RHOH, TRIP4, EGFR, RND1, HEYL, KCNJ12, SMAD4, TRAF5, BCR, NOTCH4, SEPT4, BAD, ZAP70, CASP3, APC2, ZBTB33, PIK3R1, NDN, VHL, TSHR, PRKAA1, CHAF1A, HOXA9, EAF2, TRAIP, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, ARHGEF7, SERPINA5, CTNNB1, ASCC3, PRKCA, BCL2L1, LIMK1, MYOD1, CASP6, RBL1, CD46, PARD6B, NCOR1, NFE2, PCLO, MYC, MIZF, BUB1B, RYR2, TRAF6, MLLT1, CDC45L, STX1A, MEIS1, TP53, MAPKAPK2, ZMYND11, TFDP2, RGS14, STARD13, RELA, NCK1, GIT1, HAND1, SIX3, STK11, YWHAZ, APBB1, PLAU, ZNF423, ASCC1, HIC1, COPS5, PKD2, VCP, NCOA2, ERC1, 652 4759 15360 1.752391658298065 9.468967772337791E-33 2.3672419430844478E-33 3.447657461824136E-33 GOTERM_BP_ALL GO:0007178~transmembrane receptor protein serine/threonine kinase signaling pathway 12 0.23% 4.269633511272504E-4 SMAD2, FOXH1, SMAD3, MAP3K7IP1, CDKN1C, SMAD1, TGFBR1, STUB1, MAP3K7, BMPR1A, SMAD4, SMAD7, 652 78 15360 3.624351109013686 0.893939381877698 0.009792720521194842 0.8136208983255511 GOTERM_BP_ALL GO:0044267~cellular protein metabolic process 215 4.07% 7.065153576320639E-10 KIT, HSF1, PPP5C, CAPN3, TUBA3C, GZMB, CDC37, CRY1, STAT1, MAP2K7, CDK3, PPEF1, FYN, PRKCG, ATG7, PLAT, PRKCD, ABL2, PRKD3, DUSP22, OTUD7B, PTPN7, BMX, ADRBK1, EBI3, CHEK1, MAP3K14, SRPK1, USP2, CASP5, MMP13, CYLD, RHO, PTPRG, MAP3K3, ITGB2, MAP3K5, CSNK1A1, CTBP1, GSPT2, CSNK2A1, PTPN11, PPEF2, UBB, APOBEC1, TUBB, CTSB, JUN, EPHA2, MBD2, PTPRZ1, PICK1, TSC2, IL4, STUB1, TGFBR1, MMP3, FGFR4, CDC25A, BCL10, GSK3A, MAPK1, USP9X, CRKL, RNF2, PPM1A, ANAPC10, HSP90AA1, EPHB1, ZBTB16, TRPC5, PAK7, GUCY2C, RAF1, EP300, BAG4, BMP1, TRPC4, C1QA, CDC2, WAS, LIPE, MDM4, PRKAR2A, IGF1R, NSF, BMPR1A, PEX6, CASP8, PCSK1, CHRM3, HDAC6, SIAH1, FER, NTRK1, PTPRN, PRKG1, MMP1, HCK, MDM2, MAP3K8, RAC1, MYLK, SRC, UBE2O, CDC14A, SNX17, JAK1, PLG, TNFRSF14, PARP1, TEK, MARK4, CTSS, CDKN3, MAP3K7, ALK, AKT2, NUAK1, WNT2, MARK3, TGM2, CLASP2, PTK2, TTN, CEBPE, IL12A, EIF5A, UBE2I, PARK2, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, DUSP6, CSNK1E, ETF1, CFTR, ADRB2, CASK, ATG12, FGF2, BMI1, FRK, MAPK14, CASP2, CTSF, VCPIP1, AKT1, REN, HDAC1, RPS6KA1, TUBA4A, SMAD3, MAPK8, GNA14, CRYAA, EPHB2, MAPK3, CD28, TNK2, FGFR1, GNAQ, MARK1, CALR, PSEN1, CREBBP, ATOX1, PDE4DIP, PTPN21, MBL2, EGFR, SMAD4, BCR, ZAP70, CASP3, MAP3K4, PIK3R1, VHL, PRKAA1, CHAF1A, LRP2, LNPEP, CAMK2A, MYT1, NEDD4, SERPINA5, FES, PRKCA, LIMK1, PFTK1, MYOD1, CASP6, CD46, PAK1, STAMBPL1, PTPRM, BUB1B, TRAF6, PTPRS, TP53, MAPKAPK2, RELA, NCK1, LMTK2, STK11, CSF1R, APBB1, PLAU, PKN1, COPS5, VCP, NTRK2, ERC1, 652 3482 15360 1.4546325889852458 3.7120250324651494E-6 5.3029026059192574E-8 1.3515532804042607E-6 GOTERM_BP_ALL GO:0050776~regulation of immune response 12 0.23% 0.003108881063061804 TRAF6, BCL10, IKBKG, C1QA, FYN, MBL2, SMAD3, IL4, MAP3K7, CD46, IL12A, IL27RA, 652 99 15360 2.8555493586168437 0.9999999214479346 0.055785363066100824 5.782576954546581 GOTERM_BP_ALL GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway 35 0.66% 1.4508381792518999E-12 KIT, FGFR1, PRKCA, SRC, RGS2, GRB10, PTPRG, IGF1R, GAB1, IRS2, TEK, GRB7, PTPN11, EGFR, PLAT, NTRK1, ALK, PLCE1, FRS2, EPHB1, PTK2, PIK3R1, NDN, AKT1, NCK1, EPHA2, CTGF, CSF1R, PICK1, TSC2, RAF1, EPHB2, NTRK2, ADRB2, FGFR4, 652 194 15360 4.250205553095946 7.622710462840132E-9 1.4116130486740985E-10 2.7754354370301826E-9 GOTERM_BP_ALL GO:0044260~cellular macromolecule metabolic process 218 4.13% 5.302784585886728E-10 KIT, HSF1, PPP5C, CAPN3, TUBA3C, GZMB, CDC37, CRY1, STAT1, MAP2K7, CDK3, PPEF1, FYN, PPP1R3A, PRKCG, ATG7, PLAT, PRKCD, ABL2, PRKD3, DUSP22, OTUD7B, PTPN7, BMX, ADRBK1, EBI3, CHEK1, MAP3K14, SRPK1, USP2, CASP5, MMP13, CYLD, RHO, PTPRG, MAP3K3, ITGB2, MAP3K5, CSNK1A1, CTBP1, GSPT2, CSNK2A1, PTPN11, PPEF2, UBB, APOBEC1, TUBB, CTSB, JUN, EPHA2, MBD2, PTPRZ1, PICK1, TSC2, IL4, STUB1, TGFBR1, MMP3, FGFR4, CDC25A, BCL10, GSK3A, MAPK1, WASL, USP9X, CRKL, RNF2, PPM1A, ANAPC10, HSP90AA1, EPHB1, ZBTB16, TRPC5, PAK7, GUCY2C, RAF1, EP300, BAG4, BMP1, TRPC4, C1QA, CDC2, WAS, LIPE, MDM4, PRKAR2A, IGF1R, NSF, BMPR1A, PEX6, CASP8, PCSK1, CHRM3, HDAC6, SIAH1, FER, NTRK1, PTPRN, PRKG1, MMP1, HCK, MDM2, MAP3K8, RAC1, MYLK, SRC, UBE2O, CDC14A, SNX17, JAK1, PLG, TNFRSF14, PARP1, TEK, MARK4, CTSS, CDKN3, MAP3K7, ALK, AKT2, NUAK1, WNT2, MARK3, TGM2, CLASP2, PTK2, TTN, CEBPE, IL12A, EIF5A, UBE2I, PARK2, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, DUSP6, CSNK1E, ETF1, CFTR, ADRB2, CASK, ATG12, FGF2, BMI1, FRK, MAPK14, CASP2, CTSF, VCPIP1, AKT1, REN, HDAC1, RPS6KA1, TUBA4A, SMAD3, MAPK8, GNA14, CRYAA, EPHB2, MAPK3, CD28, TNK2, FGFR1, GNAQ, MARK1, CALR, PSEN1, CREBBP, ATOX1, PDE4DIP, PTPN21, MBL2, EGFR, SMAD4, BCR, ZAP70, CASP3, MAP3K4, PIK3R1, VHL, PRKAA1, CHAF1A, LRP2, LNPEP, CAMK2A, MYT1, NEDD4, SERPINA5, FES, PRKCA, LIMK1, PFTK1, MYOD1, CASP6, CD46, PAK1, STAMBPL1, PTPRM, WIPF1, BUB1B, TRAF6, PTPRS, TP53, MAPKAPK2, RELA, NCK1, LMTK2, STK11, CSF1R, APBB1, PLAU, PKN1, COPS5, VCP, NTRK2, ERC1, 652 3534 15360 1.453227368837689 2.7860792944922608E-6 4.037801626388671E-8 1.0144147299939732E-6 GOTERM_BP_ALL GO:0007167~enzyme linked receptor protein signaling pathway 49 0.93% 1.2963076047037667E-16 KIT, FGFR1, SRC, GRB10, IRS2, TEK, GRB7, EGFR, PLAT, MAP3K7, SMAD4, ALK, PLCE1, EPHB1, NDN, PIK3R1, PTK2, FOXH1, GUCY2C, RAF1, SMAD1, ADRB2, PRKCA, RGS2, PTPRG, IGF1R, BMPR1A, GAB1, PTPN11, CDKN1C, MAP3K7IP1, NTRK1, SMAD2, FRS2, PTPRS, AKT1, EPHA2, NCK1, CTGF, SMAD7, CSF1R, PICK1, TSC2, SMAD3, STUB1, TGFBR1, EPHB2, FGFR4, NTRK2, 652 285 15360 4.050371327090732 5.833111771380572E-13 1.6209256159527285E-14 2.1094237467877974E-13 GOTERM_BP_ALL GO:0007166~cell surface receptor linked signal transduction 137 2.60% 7.95354489393776E-11 KIT, CXCL2, IKBKG, SRC, VIPR1, NFKBIA, BAI1, TNFRSF25, IRS2, TNFRSF14, TAX1BP3, PDC, TEK, MARK4, FYN, WNT1, MAP3K7, PLAT, DEFB1, LAMA3, ALK, PLCE1, AXIN1, HTR1A, WNT2, TGM2, PRKD3, SLC9A3R1, PTK2, RGS19, GNAI3, ADRBK1, FOXH1, LRP1, GNAI2, SMAD1, GNB2L1, GNAI1, ADRB2, NEDD9, RHO, RGS2, VAV1, GRM1, PTPRG, ITGB2, GAB1, CSNK1A1, CSNK2A1, CCL17, PTPN11, MAP3K7IP1, MAPK14, GNA12, FRS2, AGTR2, GPR37, AKT1, EPHA2, LIFR, CTGF, ARRB1, PICK1, TSC2, CD2, SMAD3, TNFRSF1B, GNA14, STUB1, TGFBR1, EPHB2, FGFR4, CD28, FGFR1, BCL10, OPRD1, GNAQ, MAPK1, GRB10, PSEN1, IL27RA, CDK5R1, FZD1, GRB7, EGFR, HEYL, SMAD4, NOTCH4, APC2, ZBTB33, EPHB1, PIK3R1, NDN, CCR1, IL8RA, TSHR, APP, CCR4, GUCY2C, RAF1, SAG, MDFI, ADCYAP1, CTNND1, MAGI1, GPR143, CTNNB1, VIPR2, PRKCA, CCR3, IGF1R, BMPR1A, STAT3, CHRM3, EBI2, MIF, SFRP1, CDKN1C, NTRK1, SMAD2, TRAF6, PTPRS, OPRL1, PKD1, RGS14, RELA, NCK1, DIXDC1, GIT1, SIX3, CSF1R, SMAD7, C5AR1, TGFB1I1, PARD3, TRPV1, NTRK2, 652 1868 15360 1.7277755152980125 4.1787937354875737E-7 6.529366602947562E-9 1.5215019244507744E-7 GOTERM_BP_ALL GO:0007165~signal transduction 292 5.53% 4.9842594743581815E-31 CXCL2, KIT, PPP5C, HSPA5, FGF8, GZMB, BAI1, NFKBIA, PLCD1, STAT1, RALA, IRS2, TNFRSF25, MAP2K7, HMGB1, FYN, PRKCG, PLAT, DEFB1, TICAM1, PRKCD, PLCE1, ABL2, PRKD3, SLC9A3R1, DUSP22, OTUD7B, DFFA, ARRB2, BMX, ADRBK1, FOXH1, IL4R, SRPK1, NTS, GNB2L1, GNAI1, NEDD9, RHO, RGS2, VAV1, GRM1, PTPRG, MAP3K3, ITGB2, GAB1, CCL13, CSNK1A1, MAP3K5, CSNK2A1, SOS1, PTPN11, FOXL2, GJA1, AGTR2, IRS4, GPR37, EPHA2, ARRB1, FGF1, PICK1, TSC2, CD2, CAV1, GADD45G, TNFRSF1B, MLLT4, IL4, RAB33B, STUB1, TGFBR1, FGFR4, ASIP, BCL10, TXN, MAPK1, GRB10, IL27RA, INADL, EDA2R, CDK5R1, RAB6A, SH2D1A, GRB7, NR5A1, CRKL, PPM1A, ACCN2, HSP90AA1, EPHB1, SH3GL3, CCR1, CD74, RB1, SH3BP1, APP, CCR4, GUCY2C, TRH, RAF1, EP300, MDFI, ADCYAP1, CTNND1, MAGI1, GPR143, VIPR2, CCL7, RASA2, PRKAR2A, IGF1R, BMPR1A, STAT3, CASP8, CHRM3, MIF, SFRP1, CDKN1C, DFFB, FER, NTRK1, SMAD2, PRKG1, OPRL1, HCK, CARD9, TRAF1, PRKAB1, PSTPIP1, SMAD7, IQGAP1, DAXX, RAC1, TGFB1I1, TRPV1, MICAL1, RAP1A, IKBKG, CAV3, SRC, VIPR1, CABP2, PER1, IGFALS, SNX17, JAK1, TNFRSF14, TAX1BP3, PDC, TEK, MARK4, WNT1, AKAP8, YWHAE, MAP3K7, LAMA3, DLG4, ALK, AXIN1, HTR1A, CCL8, WNT2, TGM2, PPFIA1, PTK2, SNX19, ARHGDIB, RGS19, IL12A, GNAI3, S100A1, LRP1, CHN1, S100A10, TRAF3, PPP2R2A, CAMK4, GNAI2, SMAD1, TRAF3IP2, IGFBP3, MAPK8IP3, DUSP6, CSNK1E, ADRB2, NMI, FGF7, CCL17, GUCA2A, FRK, FGF2, MAP3K7IP1, MAPK14, AR, CASP2, GNA12, MCF2, ARHGEF9, FRS2, AKT1, LIFR, CTGF, REN, RPS6KA1, RHOA, RAC3, SMAD3, KIFAP3, MAPK8, GNA14, EPHB2, TNK2, CD28, FGFR1, OPRD1, IQGAP2, GNAQ, TG, MARK1, PSEN1, CREBBP, ANKRD1, FZD1, RHOH, EGFR, RND1, HEYL, SMAD4, TRAF5, BCR, NOTCH4, BAD, ZAP70, CASP3, MAP3K4, APC2, ZBTB33, PIK3R1, NDN, IL8RA, TSHR, PRKAA1, SH2D3C, CSPG4, TRAIP, AKAP9, HIF1A, SAG, ARHGEF7, FES, CTNNB1, DTNA, PRKCA, BCL2L1, LIMK1, CCR3, SLA, PAK1, ITPR1, EBI2, CCL5, BUB1B, RYR2, TRAF6, PTPRS, TP53, PDE4D, MAPKAPK2, NPHP1, PKD1, SH3GL2, RGS14, STARD13, RELA, NCK1, DIXDC1, GIT1, SIX3, GMIP, CSF1R, YWHAZ, APBB1, PLAU, PKN1, PLCG1, C5AR1, PKD2, PARD3, VCP, NCOA2, NTRK2, ERC1, 652 3758 15360 1.830499841646614 2.6187299278277885E-27 3.741042754039698E-28 9.53481307915426E-28 GOTERM_BP_ALL GO:0007155~cell adhesion 58 1.10% 3.28153304251806E-5 DSC1, SYMPK, BCL10, DSG3, BAI1, PSEN1, CDK5R1, IGFALS, MYF5, EGFR, RND1, LAMA3, NRXN2, ABL2, TGM2, JAM2, PPFIA1, CCR1, TTN, ARHGDIB, IL12A, DAG1, APP, CD44, NEDD9, CTNND1, MAGI1, HSPG2, BMP1, CTNNB1, CASK, VAV1, KNG1, NLGN1, CCR3, ITGB2, MPZ, PTPRM, CCL5, PKP2, FER, LAMA1, PTPRS, NPHP1, PKD1, PSTPIP1, ZEB2, CTGF, CD2, DSG2, SELE, TGFB1I1, RAC1, ACTN1, MLLT4, PKD2, F11R, PPFIA2, 652 774 15360 1.7653493127883197 0.15836981799240557 9.265305858150441E-4 0.06275656121993434 GOTERM_BP_ALL GO:0007154~cell communication 328 6.22% 9.224200546144669E-39 CXCL2, KIT, PPP5C, HSPA5, FGF8, GZMB, BAI1, HAP1, NFKBIA, PLCD1, STAT1, RALA, IRS2, SNX5, TNFRSF25, MAP2K7, HMGB1, FYN, PRKCG, PLAT, DEFB1, TICAM1, PRKCD, PLCE1, ABL2, PRKD3, SLC9A3R1, DUSP22, OTUD7B, DFFA, ARRB2, BMX, ADRBK1, FOXH1, CACNA1B, IL4R, SRPK1, NTS, GNB2L1, GNAI1, NEDD9, PHOX2A, RHO, RGS2, VAV1, NLGN1, SLC6A4, GRM1, PTPRG, MAP3K3, ITGB2, GAB1, CCL13, CSNK1A1, MAP3K5, MPZ, CSNK2A1, SOS1, PTPN11, PPFIBP2, FOXL2, GJA1, AGTR2, UBB, DLG2, IRS4, GPR37, EPHA2, ARRB1, FGF1, PICK1, TSC2, CD2, CAV1, GADD45G, TNFRSF1B, MLLT4, IL4, RAB33B, STUB1, TGFBR1, FGFR4, ASIP, BCL10, TXN, MAPK1, GRB10, IL27RA, INADL, EDA2R, CDK5R1, RAB6A, SH2D1A, GRB7, NR5A1, PMP22, GJA3, CRKL, SNCB, NRXN2, PPM1A, ACCN2, HSP90AA1, EPHB1, CCR1, SH3GL3, CD74, SH3BP1, RB1, APP, GUCY2C, CCR4, TRH, RAF1, EP300, AREG, MDFI, MAGI1, CTNND1, ADCYAP1, GPR143, VIPR2, SLC6A1, CCL7, C1QA, RASA2, PRKAR2A, IGF1R, BMPR1A, CASP8, STAT3, PCSK1, SALL1, CHRM3, EFNA2, TH, MIF, SFRP1, DFFB, CHAT, CDKN1C, FER, NTRK1, SMAD2, PRKG1, OPRL1, HCK, CARD9, TRAF1, PRKAB1, PSTPIP1, SMAD7, IQGAP1, DAXX, RAC1, TGFB1I1, TRPV1, MICAL1, RAP1A, IKBKG, CAV3, SRC, NOS1, VIPR1, CABP2, PER1, IGFALS, SNX17, JAK1, TNFRSF14, TAX1BP3, PDC, TEK, MARK4, WNT1, AKAP8, YWHAE, MAP3K7, LAMA3, DLG4, ALK, AXIN1, HTR1A, CCL8, WNT2, TGM2, PPFIA1, PTK2, SNX19, ARHGDIB, RGS19, IL12A, GNAI3, SNPH, S100A1, LRP1, CHN1, PARK2, S100A10, TRAF3, PPP2R2A, CAMK4, GNAI2, SMAD1, TRAF3IP2, IGFBP3, MAPK8IP3, DUSP6, CSNK1E, ADRB2, CFTR, NMI, SNCAIP, FGF7, PLP1, CCL17, GUCA2A, FRK, FGF2, MAP3K7IP1, MAPK14, AR, CASP2, GNA12, MCF2, ARHGEF9, FRS2, AKT1, LIFR, CTGF, REN, RPS6KA1, GJA8, GABARAPL2, SNAP25, RHOA, RAC3, SMAD3, KIFAP3, GNA14, MAPK8, EPHB2, TNK2, CD28, FGFR1, OPRD1, GNAQ, IQGAP2, LIN7A, TG, MARK1, PSEN1, CREBBP, ANKRD1, FZD1, RHOH, EGFR, RND1, HEYL, SMAD4, TRAF5, BCR, NOTCH4, BAD, ZAP70, CASP3, MAP3K4, APC2, ZBTB33, PIK3R1, NDN, IL8RA, TSHR, PRKAA1, SH2D3C, CSPG4, TRAIP, LNPEP, AKAP9, HIF1A, SAG, ARHGEF7, FES, CTNNB1, DTNA, PRKCA, BCL2L1, LIMK1, CCR3, SLA, PAK1, ITPR1, EBI2, CCL5, PCLO, BUB1B, RYR2, TRAF6, PTPRS, STX1A, TP53, PDE4D, MAPKAPK2, NPHP1, PKD1, SH3GL2, RGS14, STARD13, RELA, NCK1, KIF5A, DIXDC1, GIT1, SIX3, GMIP, CSF1R, YWHAZ, APBB1, PLAU, PKN1, PLCG1, C5AR1, PKD2, PARD3, VCP, NCOA2, NTRK2, ERC1, 652 4123 15360 1.8741490575835986 4.84639496694441E-35 1.6154649889814696E-35 1.7645756298321016E-35 GOTERM_BP_ALL GO:0044238~primary metabolic process 416 7.88% 1.604862343210695E-7 KIT, SLC2A2, PPP5C, CAPN3, CDC37, CRY1, IRS2, CDK3, TFCP2, HMGB1, PPP1R3A, FYN, RAG1, PRKCG, ATG7, PLCE1, ABL2, PRKD3, CHKA, DUSP22, RFXANK, DFFA, RCC1, MAP3K14, GCM1, CLTCL1, MMP13, GTF2H1, CYLD, MAX, ITGB2, MAP3K5, CSNK1A1, CTBP1, PPEF2, CLIP1, HOXB9, UBB, RELB, TUBB, E2F2, ATF7IP2, CTSB, JUN, PTPRZ1, HOXB7, PICK1, PAX3, TSC2, ATP2B2, CAV1, STUB1, TGFBR1, MMP3, FGFR4, CDC25A, BCL10, IL27RA, EDA2R, SMARCA4, U2AF2, NR5A1, SNCB, CBX2, RNF2, PPM1A, ANAPC10, HSP90AA1, FOSL1, TAF13, RB1, PAK7, EP300, BAG4, TRPC4, WAS, LIPE, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, TH, INSIG2, MIF, CDKN1C, PTPRN, PRKG1, SETDB1, ZEB2, GATA2, DAXX, CUGBP2, MAP3K8, TGFB1I1, XAB2, MYLK, IKBKG, CAV3, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, ERCC3, RYBP, CTSS, CDKN3, MAP3K7, ALK, NUAK1, CPNE1, CLASP2, CEBPE, DAG1, UBE2I, FOS, PPP2R2A, SMAD1, IGFBP3, DUSP6, EYA1, CSNK1E, ETF1, ASCC2, PLP1, ORC2L, ERCC4, FGF2, AR, CASP2, ERCC2, CTSF, VCPIP1, HDAC1, RPS6KA1, DACH1, SMAD3, KIFAP3, MAPK8, GNA14, EPHB2, GNAQ, LIN7A, CALR, PSEN1, FZD1, PTPN21, RHOH, PLAG1, EGFR, BCR, ZAP70, CASP3, NDN, PIK3R1, MYOG, SI, TBP, HIF1A, CAMK2A, NEDD4, ASCC3, LIMK1, MYOD1, RBL1, CASP6, PAK1, PTPRM, NCOR1, MIZF, RAG2, MLLT1, TRAF6, CDC45L, MAPKAPK2, RELA, PLA2G2A, SIX3, HAND1, STK11, DDC, PLAU, ZNF423, PLCG1, RAD52, PARD3, NCOA2, HSF1, MAFK, TUBA3C, MNDA, GATA4, LLGL1, GZMB, POU2AF1, PLCD1, STAT1, MAP2K7, PPEF1, PRM1, PLAT, PRKCD, POU1F1, SLC9A3R1, OTUD7B, PTPN7, BMX, ADRBK1, FOXH1, EBI3, SRY, POU3F3, CHEK1, SRPK1, USP2, CASP5, PHOX2A, RHO, MCM7, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, PTPN11, GLS2, PPFIBP2, FOXL2, GJA1, RFXAP, APOBEC1, ZNF208, EPHA2, MBD2, CUBN, GTF2F2, GADD45G, TNFRSF1B, WRN, IL4, SLC9A3R2, SREBF2, KPNA2, GSK3A, ABCB4, MAPK1, CBX5, HOXC8, WASL, USP9X, CRKL, MPP6, DBP, TCEA2, EPHB1, ZBTB16, TRPC5, CD74, APP, GUCY2C, RAF1, PTGS2, MDFI, CTNND1, MAGI1, BMP1, C1QA, CDC2, PRKAR2A, NSF, PEX6, CASP8, PCSK1, SALL1, CHRM3, HDAC6, PAX5, BICD1, DFFB, SIAH1, FER, NTRK1, SMAD2, MMP1, HCK, TRAF1, PRKAB1, TLN1, SMAD7, HAND2, MDM2, SIX1, FANCA, POU3F2, RAC1, HDAC4, SOX10, WT1, PER1, MEOX1, MEOX2, JAK1, YBX1, PARP1, HDAC5, TEK, MARK4, SFRS2IP, DLG4, AKT2, AXIN1, WNT2, MARK3, TGM2, PTK2, PPARA, NOL3, TTN, IL12A, EIF5A, LRP1, PARK2, HOXD4, CHAF1B, BRSK2, TCF3, CAMK4, PRKACA, CFTR, ADRB2, CASK, NMI, SNCAIP, ASF1A, TJP1, ATG12, TP73, BMI1, FRK, MAPK14, TTR, AP2B1, AKT1, REN, CTGF, TUBA4A, ATR, FABP4, CRYAA, MAPK3, CD28, TNK2, FGFR1, MARK1, TG, ETS1, CREBBP, MSC, ANKRD1, ATOX1, PDE4DIP, MYF5, MBL2, TRIP4, HEYL, SMAD4, NOTCH4, XPA, APC2, MAP3K4, ZBTB33, VHL, PRKAA1, CHAF1A, HOXA9, LRP2, EAF2, LNPEP, MITF, NHLH1, HOXB6, MYT1, SERPINA5, FES, CTNNB1, PRKCA, PFTK1, CD46, PARD6B, STAMBPL1, NFE2, SLC2A4, WIPF1, MYC, BUB1B, PTPRS, MEIS1, TP53, PDE4D, ZMYND11, TFDP2, NCK1, LMTK2, CSF1R, APBB1, PKN1, ASCC1, HIC1, COPS5, VCP, NTRK2, ERC1, 652 8291 15360 1.182034181494754 8.42839353889846E-4 7.46187253786168E-6 3.0700729518606806E-4 GOTERM_BP_ALL GO:0044237~cellular metabolic process 398 7.54% 1.011114805214718E-4 KIT, PPP5C, CAPN3, CDC37, CRY1, IRS2, CDK3, PTX3, TFCP2, HMGB1, PPP1R3A, FYN, RAG1, PRKCG, ATG7, PLCE1, ABL2, PRKD3, DUSP22, RFXANK, DFFA, RCC1, SLC34A1, MAP3K14, GCM1, MMP13, GTF2H1, CYLD, MAX, ITGB2, MAP3K5, CSNK1A1, CTBP1, PPEF2, CLIP1, HOXB9, UBB, RELB, TUBB, E2F2, ATF7IP2, CTSB, JUN, PTPRZ1, HOXB7, PICK1, PAX3, TSC2, ATP2B2, CAV1, STUB1, TGFBR1, MMP3, FGFR4, CDC25A, BCL10, IL27RA, EDA2R, SMARCA4, U2AF2, NR5A1, SNCB, CBX2, RNF2, PPM1A, ANAPC10, HSP90AA1, FOSL1, TAF13, RB1, NCF2, PAK7, EP300, BAG4, TRPC4, WAS, LIPE, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, TH, INSIG2, MIF, CDKN1C, CHAT, PTPRN, PRKG1, SETDB1, ZEB2, GATA2, DAXX, CUGBP2, MAP3K8, TGFB1I1, XAB2, MICAL1, MYLK, IKBKG, CAV3, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, ERCC3, RYBP, CTSS, CDKN3, MAP3K7, ALK, NUAK1, CLASP2, CEBPE, UBE2I, FOS, PPP2R2A, SMAD1, IGFBP3, DUSP6, EYA1, CSNK1E, ETF1, ASCC2, PLP1, ORC2L, ERCC4, FGF2, AR, CASP2, ERCC2, CTSF, VCPIP1, HDAC1, RPS6KA1, DACH1, SMAD3, MAPK8, GNA14, EPHB2, GNAQ, CALR, PSEN1, FZD1, PTPN21, RHOH, PLAG1, EGFR, BCR, ZAP70, CASP3, NDN, PIK3R1, MYOG, TBP, HIF1A, CAMK2A, NEDD4, ASCC3, LIMK1, MYOD1, RBL1, CASP6, PAK1, PTPRM, NCOR1, MIZF, RAG2, MLLT1, TRAF6, CDC45L, MAPKAPK2, RELA, PLA2G2A, SIX3, HAND1, STK11, DDC, PLAU, ZNF423, RAD52, NCOA2, HSF1, MAFK, MNDA, TUBA3C, GATA4, GZMB, POU2AF1, PLCD1, STAT1, MAP2K7, PPEF1, PRM1, PLAT, PRKCD, POU1F1, OTUD7B, PTPN7, BMX, ADRBK1, FOXH1, EBI3, SRY, POU3F3, CHEK1, SRPK1, USP2, CASP5, PHOX2A, RHO, MCM7, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, PTPN11, GLS2, PPFIBP2, FOXL2, RFXAP, APOBEC1, ZNF208, EPHA2, MBD2, CUBN, GTF2F2, GADD45G, TNFRSF1B, WRN, IL4, SREBF2, GPHN, KPNA2, GSK3A, MAPK1, CBX5, HOXC8, WASL, USP9X, CRKL, DBP, TCEA2, EPHB1, ZBTB16, TRPC5, CD74, APP, GUCY2C, RAF1, PTGS2, MDFI, CTNND1, GPR143, BMP1, C1QA, CDC2, PRKAR2A, NSF, PEX6, CASP8, PCSK1, SALL1, CHRM3, HDAC6, PAX5, BICD1, DFFB, SIAH1, FER, NTRK1, SMAD2, MMP1, HCK, PRKAB1, SMAD7, HAND2, MDM2, SIX1, FANCA, POU3F2, RAC1, HDAC4, SOX10, WT1, NOS1, PER1, MEOX1, MEOX2, JAK1, YBX1, PARP1, HDAC5, TEK, MARK4, SFRS2IP, AKT2, WNT2, MARK3, TGM2, PTK2, PPARA, NOL3, TTN, IL12A, EIF5A, PARK2, HOXD4, CHAF1B, BRSK2, TCF3, CAMK4, PRKACA, CFTR, ADRB2, CASK, NMI, SNCAIP, ASF1A, ATG12, TP73, BMI1, FRK, MAPK14, TTR, AKT1, REN, CTGF, TUBA4A, ATR, FABP4, CRYAA, MAPK3, CD28, TNK2, FGFR1, MARK1, TG, ETS1, CREBBP, MSC, ANKRD1, ATOX1, PDE4DIP, MYF5, MBL2, TRIP4, HEYL, SMAD4, NOTCH4, XPA, MAP3K4, ZBTB33, VHL, PRKAA1, CHAF1A, HOXA9, LRP2, EAF2, LNPEP, MITF, NHLH1, HOXB6, MYT1, FES, SERPINA5, CTNNB1, PRKCA, PFTK1, CD46, STAMBPL1, NFE2, WIPF1, MYC, BUB1B, PTPRS, SYNJ1, PDE4D, TP53, MEIS1, ZMYND11, TFDP2, NCK1, LMTK2, CSF1R, APBB1, PKN1, ASCC1, HIC1, COPS5, VCP, NTRK2, ERC1, 652 8269 15360 1.1338972450137146 0.41214007231672734 0.0026661208649141344 0.1932475501892239 GOTERM_BP_ALL GO:0043687~post-translational protein modification 151 2.86% 4.6588709218532325E-24 KIT, PPP5C, SRC, UBE2O, CDC14A, CRY1, JAK1, STAT1, PARP1, TNFRSF14, MAP2K7, CDK3, TEK, PPEF1, MARK4, FYN, CDKN3, PRKCG, MAP3K7, ATG7, PRKCD, ALK, AKT2, ABL2, NUAK1, WNT2, TGM2, MARK3, PRKD3, PTK2, DUSP22, OTUD7B, PTPN7, TTN, BMX, IL12A, ADRBK1, UBE2I, PARK2, CHEK1, MAP3K14, SRPK1, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, USP2, CSNK1E, DUSP6, CFTR, CYLD, CASK, RHO, PTPRG, MAP3K3, ITGB2, CSNK1A1, MAP3K5, CTBP1, CSNK2A1, ATG12, FRK, BMI1, FGF2, PTPN11, PPEF2, MAPK14, UBB, VCPIP1, JUN, AKT1, EPHA2, PTPRZ1, RPS6KA1, HDAC1, PICK1, IL4, STUB1, TGFBR1, GNA14, MAPK8, EPHB2, MAPK3, FGFR4, TNK2, CDC25A, FGFR1, BCL10, GSK3A, GNAQ, MAPK1, MARK1, PSEN1, CREBBP, PTPN21, EGFR, USP9X, CRKL, BCR, PPM1A, RNF2, ZAP70, ANAPC10, MAP3K4, EPHB1, ZBTB16, PIK3R1, VHL, PRKAA1, PAK7, GUCY2C, RAF1, CAMK2A, EP300, NEDD4, FES, PRKCA, LIMK1, PFTK1, CDC2, LIPE, MYOD1, PRKAR2A, IGF1R, BMPR1A, PAK1, HDAC6, STAMBPL1, PTPRM, FER, SIAH1, NTRK1, PTPRN, BUB1B, PRKG1, TRAF6, PTPRS, HCK, TP53, MAPKAPK2, LMTK2, STK11, CSF1R, PKN1, MDM2, MAP3K8, VCP, NTRK2, ERC1, MYLK, 652 1522 15360 2.3372540167522553 2.4477707823416884E-20 1.2238853911708442E-21 8.912349693732144E-21 GOTERM_BP_ALL GO:0021700~developmental maturation 16 0.30% 3.2200050945665096E-7 CTNNB1, FGFR1, GNAQ, ACTC1, NLGN1, AKT1, PLP1, TTN, REN, GATA2, APP, PICK1, CDKN1C, PTGS2, RND1, SOX10, 652 73 15360 5.163459114211279 0.0016903606775576785 1.4216629608099218E-5 6.159803123018115E-4 GOTERM_BP_ALL GO:0060047~heart contraction 14 0.27% 1.3595722660364772E-7 RYR2, PRKCA, ACTC1, TNNT2, CSRP3, ADRBK1, CACNA1B, SCN5A, S100A1, CUGBP2, CACNA1C, PLN, KCNJ12, ADRB2, 652 51 15360 6.466979429808734 7.140642517446949E-4 6.377830706671972E-6 2.6008380007436216E-4 GOTERM_BP_ALL GO:0040008~regulation of growth 19 0.36% 0.0024059933123882302 UBB, TP53, NDN, AKT1, CTGF, TSHR, NOV, RB1, APP, APBB1, TP73, POU3F2, SMAD3, WRN, IGFBP3, SMAD4, PLCE1, NEDD9, ADRB2, 652 202 15360 2.215878029520743 0.9999968126492984 0.04530193262294979 4.503610647757417 GOTERM_BP_ALL GO:0040007~growth 25 0.47% 0.0014613810557184616 FGFR1, NOV, PLG, SMARCA4, TP73, AR, SMAD4, PLCE1, SETDB1, UBB, TP53, NDN, AKT1, TSHR, CTGF, RB1, APP, APBB1, POU3F2, SMAD3, WRN, PTGS2, IGFBP3, NEDD9, ADRB2, 652 291 15360 2.023907406236165 0.9995397367044874 0.029120325851744955 2.75887292324718 GOTERM_BP_ALL GO:0043623~cellular protein complex assembly 9 0.17% 0.003642966861650906 PICK1, SMAD3, SRC, PTK2, NCK1, TGFBR1, MBD2, SMAD4, ADRB2, 652 60 15360 3.5337423312883436 0.9999999952971459 0.06355841776542659 6.743521277857489 GOTERM_BP_ALL GO:0000279~M phase 23 0.44% 0.005451208225096877 BUB1B, CD28, CDC25A, PPP5C, KPNA2, ANAPC10, CDC2, TP53, CLASP2, FOSL1, TTN, RCC1, CALR, RB1, UBE2I, CHEK1, CDK3, AKAP8, RAD52, PRM1, CRYAA, CLIP1, NEDD9, 652 287 15360 1.8879459609670592 0.999999999999663 0.08875340695069811 9.928470145925905 GOTERM_BP_ALL GO:0000278~mitotic cell cycle 27 0.51% 0.0010750751693037893 CDC25A, CD28, PPP5C, KPNA2, CDC2, GSPT2, CDK3, MARK4, AKAP8, CDKN1C, CDKN3, PRM1, CLIP1, RNF2, BUB1B, ANAPC10, TP53, CLASP2, FOSL1, RCC1, TTN, RB1, UBE2I, APBB1, CHEK1, MDM2, NEDD9, 652 318 15360 2.000231508276421 0.996487697131909 0.02226427959123367 2.0366824910645898 GOTERM_BP_ALL GO:0035295~tube development 23 0.44% 2.4665914168535915E-7 NOTCH4, CTNNB1, FGFR1, BCL10, WNT2, AGTR2, KCNJ8, KNG1, ZEB2, FGF1, BMPR1A, CASP8, FOXH1, CAV1, FGF2, MAP3K7IP1, NTS, EP300, MAP3K7, CD44, SMAD4, ADRB2, CFTR, 652 147 15360 3.685989733316639 0.0012951079130940624 1.1076411221444538E-5 4.718541567805268E-4 GOTERM_BP_ALL GO:0043549~regulation of kinase activity 42 0.80% 9.309482127624216E-15 CDC25A, KIT, GTF2H1, CDK5R2, PRKCA, IKBKG, CAV3, GRM1, CDC37, RBL1, CDK5R1, GAB1, MAP3K5, PTPN11, FGF2, MAP3K7IP1, CDKN1C, EGFR, CDKN3, MAP3K7, PLCE1, FRS2, TRAF6, CASP3, MAP3K4, PRKD3, DUSP22, PRKAA1, RB1, DAXX, PICK1, PKN1, CHEK1, C5AR1, FABP4, CAV1, GADD45G, GNB2L1, PARD3, MDFI, DUSP6, ADRB2, 652 236 15360 4.192575647291256 4.899813887959681E-11 1.1395329124752607E-12 1.7841284005726266E-11 GOTERM_BP_ALL GO:0009268~response to pH 4 0.08% 0.005255204628673103 GJA1, ACCN2, KCNJ8, TRPV1, 652 9 15360 10.47034764826176 0.9999999999990513 0.08676867970869917 9.58828678206337 GOTERM_BP_ALL GO:0055082~cellular chemical homeostasis 28 0.53% 3.944794817492495E-7 CCL7, BCL2L1, PRKCA, CAV3, KNG1, CCR3, CALR, CSRP3, CCL13, ATOX1, CCL5, ATP7B, PLCE1, MYC, RYR2, CP, OPRL1, TGM2, SLC9A3R1, CCR1, IREB2, APP, C5AR1, CACNA1C, ATP2B2, CCR4, PLN, PKD2, 652 214 15360 3.0823920646751906 0.0020704492627128257 1.7271480895364455E-5 7.546305908268103E-4 GOTERM_BP_ALL GO:0055080~cation homeostasis 25 0.47% 7.763257656834973E-7 CCL7, PRKCA, KNG1, CCR3, CALR, CSRP3, CCL13, ATOX1, CCL5, ATP7B, PLCE1, MYC, CP, RYR2, OPRL1, TGM2, CCR1, IREB2, APP, CACNA1C, ATP2B2, CCR4, C5AR1, PLN, PKD2, 652 182 15360 3.2360277759050766 0.00407051007957826 3.1135524104608514E-5 0.0014850890109774362 GOTERM_BP_ALL GO:0007049~cell cycle 94 1.78% 3.601019773419317E-16 CD28, CDC25A, PPP5C, KPNA2, BCL10, CDK5R2, RAP1A, MAPK1, FGF8, CDC37, CALR, CDK5R1, CDC14A, STAT1, HDAC5, CDK3, ERCC3, MARK4, AKAP8, EGFR, CDKN3, PRM1, RNF2, AXIN1, SEPT4, ANAPC10, CASP3, APC2, CLASP2, NDN, FOSL1, VHL, TTN, RCC1, CHAF1A, RB1, UBE2I, CHEK1, CHAF1B, SRPK1, EP300, SEPT8, DUSP6, ADCYAP1, NEDD9, GTF2H1, CYLD, PRKCA, CDC2, RGS2, MCM7, MDM4, FGF7, IGF1R, RBL1, PARD6B, GSPT2, HDAC6, TP73, FRK, PTPN11, FGF2, CDKN1C, SIAH1, CLIP1, ERCC2, MYC, BUB1B, UBB, CDC45L, TP53, ZMYND11, TFDP2, E2F2, STARD13, FGF1, STK11, DAXX, APBB1, TSC2, ATR, MDM2, HIC1, RAD52, HDAC4, GADD45G, COPS5, PKD2, CRYAA, WT1, EPHB2, PARD3, MAPK3, PLEKHO1, 652 894 15360 2.4770453328941406 1.7499335314141717E-12 4.6074255521943996E-14 6.328271240363392E-13 GOTERM_BP_ALL GO:0035282~segmentation 9 0.17% 1.051815428203522E-4 FRS2, MEOX2, MYF5, BMI1, SFRP1, HOXB6, ZEB2, EP300, MEOX1, 652 36 15360 5.88957055214724 0.42457874609498447 0.0027594501535409544 0.20101897074109587 GOTERM_BP_ALL GO:0055074~calcium ion homeostasis 20 0.38% 7.636523707701424E-7 RYR2, OPRL1, TGM2, CCL7, PRKCA, KNG1, CCR3, CCR1, CALR, CSRP3, CCL13, C5AR1, ATP2B2, CACNA1C, CCR4, CCL5, PLN, PKD2, ATP7B, PLCE1, 652 121 15360 3.8939309435684226 0.004004192842943954 3.1102082894363114E-5 0.0014608453364539642 GOTERM_BP_ALL GO:0055070~copper ion homeostasis 4 0.08% 0.005255204628673103 ATOX1, APP, CP, ATP7B, 652 9 15360 10.47034764826176 0.9999999999990513 0.08676867970869917 9.58828678206337 GOTERM_BP_ALL GO:0000187~activation of MAPK activity 13 0.25% 6.557043501514506E-6 FRS2, GRM1, PRKAA1, GAB1, MAP3K5, DAXX, PKN1, C5AR1, FGF2, PTPN11, MDFI, PLCE1, ADRB2, 652 60 15360 5.104294478527607 0.03386414644214564 2.1801939174004303E-4 0.012542779615642985 GOTERM_BP_ALL GO:0055066~di-, tri-valent inorganic cation homeostasis 25 0.47% 7.610818322476301E-8 CCL7, PRKCA, KNG1, CCR3, CALR, CSRP3, CCL13, ATOX1, CCL5, ATP7B, PLCE1, MYC, CP, RYR2, OPRL1, TGM2, CCR1, IREB2, APP, CACNA1C, ATP2B2, CCR4, C5AR1, PLN, PKD2, 652 161 15360 3.658118355370956 3.997924714336243E-4 3.7723741086459484E-6 1.4559370428157692E-4 GOTERM_BP_ALL GO:0055065~metal ion homeostasis 20 0.38% 2.3288281802794952E-6 RYR2, OPRL1, TGM2, CCL7, PRKCA, KNG1, CCR3, CCR1, CALR, CSRP3, CCL13, C5AR1, ATP2B2, CACNA1C, CCR4, CCL5, PLN, PKD2, ATP7B, PLCE1, 652 130 15360 3.624351109013686 0.012161125977267928 8.496637283861297E-5 0.004454919081220421 GOTERM_BP_ALL GO:0000165~MAPKKK cascade 36 0.68% 1.0564101355379713E-15 FGFR1, PRKCA, MAPK1, CAV3, GRM1, MAP3K3, PAK1, EDA2R, GAB1, MAP3K5, MAP2K7, FGF2, PTPN11, MAP3K7IP1, MAP3K7, CRKL, PLCE1, FRS2, MAP3K4, CARD9, MAPKAPK2, DUSP22, REN, PRKAA1, SH2D3C, DAXX, PKN1, C5AR1, CAV1, GADD45G, SMAD1, MAPK8, MAPK8IP3, DUSP6, MDFI, ADRB2, 652 163 15360 5.20305619330799 5.8331117713805725E-12 1.4577228313328305E-13 2.120525977034049E-12 GOTERM_BP_ALL GO:0035239~tube morphogenesis 17 0.32% 1.2146326117694493E-5 NOTCH4, CTNNB1, BCL10, FGFR1, AGTR2, WNT2, KCNJ8, KNG1, ZEB2, CASP8, CAV1, NTS, MAP3K7, CD44, SMAD4, CFTR, ADRB2, 652 108 15360 3.708248125426039 0.061823503405176616 3.843669855415621E-4 0.0232331801674035 GOTERM_BP_ALL GO:0000122~negative regulation of transcription from RNA polymerase II promoter 24 0.45% 8.357354135626831E-8 CBX2, RNF2, CTNNB1, ZMYND11, MDM4, VHL, MBD2, RBL1, HAND1, TWIST1, RB1, STAT3, ORC2L, HDAC5, MDM2, HMGB1, SMARCA4, BMI1, SMAD3, HDAC4, CDKN1C, RYBP, MDFI, NCOA2, 652 150 15360 3.7693251533742336 4.389990161104418E-4 4.103686947920515E-6 1.5987480089796335E-4 GOTERM_BP_ALL GO:0007017~microtubule-based process 19 0.36% 0.005919682982075768 BUB1B, KPNA2, WNT2, TUBA3C, TUBB, CLASP2, NLGN1, HAP1, KIF5A, RCC1, KIF1C, TUBA4A, HDAC6, KIFC3, MARK4, KIFAP3, PCLO, CRYAA, CFTR, 652 220 15360 2.0345789180145006 0.9999999999999717 0.09457002594926522 10.736645844221492 GOTERM_BP_ALL GO:0007010~cytoskeleton organization and biogenesis 57 1.08% 1.8462400692326374E-10 TNK2, KPNA2, TUBA3C, LLGL1, HAP1, MARK1, CALR, KIF1C, FHOD1, PDE4DIP, MARK4, KIFC3, RND1, WASL, PLCE1, ABL2, WNT2, DOCK2, CLASP2, RCC1, TTN, ARHGDIB, VIM, RAF1, NEDD9, CFTR, GFAP, LIMK1, WAS, NLGN1, PAK1, FMNL1, HDAC6, WIPF1, PCLO, SYNPO, ABLIM3, BUB1B, PRKG1, NPHP1, TUBB, ACTC1, TNNT2, NCK1, KIF5A, TLN1, SHANK1, APBB1, RHOA, TUBA4A, SGCG, RAC3, RAC1, KIFAP3, ACTN1, CRYAA, MICAL1, 652 526 15360 2.5528936994098297 9.70013935064351E-7 1.4477826826286844E-8 3.5318289404173697E-7 GOTERM_BP_ALL GO:0048878~chemical homeostasis 33 0.63% 2.2230952861763866E-7 CCL7, PRKCA, BCL2L1, CAV3, KNG1, CCR3, CALR, SLC9A1, CSRP3, CCL13, ATOX1, CCL5, SLC2A4, ATP7B, MYC, PLCE1, RYR2, CP, OPRL1, TGM2, SLC9A3R1, CCR1, IREB2, APP, C5AR1, CACNA1C, CAV1, ATP2B2, CCR4, FABP4, HIF1A, PLN, PKD2, 652 275 15360 2.826993865030675 0.0011673325295937786 1.0156595316224148E-5 4.2527391277413784E-4 GOTERM_BP_ALL GO:0048869~cellular developmental process 192 3.64% 1.4321990911317047E-34 HSPA5, IKBKG, GZMB, NFKBIA, BAI1, STAT1, TNFRSF25, PLG, TNFRSF14, HDAC5, HMGB1, ERCC3, MARK4, FYN, WNT1, RYBP, PRM1, PRKCG, RAG1, MAP3K7, S100A7, LAMA3, AXIN1, WNT2, TGM2, DUSP22, NOL3, DFFA, TTN, IL12A, CEBPE, EIF5A, SRY, SRPK1, TRAF3, BRSK2, TCF3, IGFBP3, CASP5, GCM1, ADRB2, CFTR, SERPINB2, NLGN1, PLP1, ITGB2, CSRP3, MAP3K5, ATG12, TP73, PTPN11, FGF2, FOXL2, CASP2, GNA12, MCF2, ERCC2, FRS2, GJA1, AGTR2, UBB, RELB, E2F2, TUBB, JUN, CTSB, AKT1, ATG5, EPHA2, CTGF, REN, FGF1, PTPRZ1, HDAC1, PICK1, PAX3, CD2, ATP2B2, SMAD3, WRN, TNFRSF1B, GADD45G, ACTN1, IL4, CRYAA, MAPK8, CD28, FGFR1, BCL10, NAIP, GNAQ, MAPK1, ETS1, CALR, PSEN1, CDK5R1, EDA2R, MYF5, SMARCA4, FZD1, RHOH, HOXC8, RND1, NR5A1, TRAF5, NOTCH4, PPP3R1, SEPT4, BAD, ZAP70, CASP3, ZBTB16, PIK3R1, NDN, VHL, PRKAA1, CD74, CSPG4, RB1, APP, EAF2, TRAIP, PAK7, MYOG, CCR4, MITF, TBP, NHLH1, PTGS2, RAF1, MYT1, EP300, MDFI, BAG4, LMO2, BMP1, CTNNB1, ANXA13, PRKCA, BCL2L1, LIMK1, CDC2, KNG1, DLX5, MDM4, MYOD1, IGF1R, CASP6, BMPR1A, PARD6B, TWIST1, PAK1, CASP8, RABEP1, SALL1, PAX5, MIF, SFRP1, DFFB, CHAT, CDKN1C, SIAH1, NTRK1, BUB1B, SMAD2, RAG2, PRKG1, TRAF6, CARD9, TP53, ACTC1, TRAF1, RELA, ZEB2, HAND1, GATA2, HAND2, DAXX, YWHAZ, CUGBP2, APBB1, ZNF423, SIX1, POU3F2, TGFB1I1, HDAC4, SOX10, F11R, PARD3, VCP, NTRK2, ERC1, 652 1835 15360 2.464953778773341 7.524774024805977E-31 1.2541290041343293E-31 2.7397752256535287E-31 GOTERM_BP_ALL GO:0003018~vascular process in circulatory system 8 0.15% 0.002025968773729387 WNT2, AGTR2, KCNJ8, CAV1, KNG1, NTS, ADRB2, CFTR, 652 43 15360 4.3829362248537596 0.9999764229593753 0.03897835578139541 3.805287110796962 GOTERM_BP_ALL GO:0048858~cell projection morphogenesis 20 0.38% 0.005467299183564665 PRKG1, GJA1, UBB, LIMK1, DLX5, BAI1, NDN, NCK1, PTPRZ1, PARD6B, CDK5R1, APBB1, RAC3, POU3F2, RAC1, PTPN11, CHAT, SIAH1, PARD3, MCF2, 652 235 15360 2.004960187965018 0.9999999999996906 0.08873007941685407 9.956343626704744 GOTERM_BP_ALL GO:0006996~organelle organization and biogenesis 95 1.80% 2.7575813018006468E-9 TNK2, KPNA2, PEX26, TUBA3C, LLGL1, HAP1, MARK1, SYP, CALR, CREBBP, KIF1C, FHOD1, HDAC5, PDE4DIP, CBX5, HMGB1, SMARCA4, KIFC3, MARK4, AKAP8, RND1, WASL, PRM1, PLCE1, CBX2, RNF2, ABL2, WNT2, CASP3, HSP90AA1, DOCK2, CLASP2, DFFA, ARHGDIB, TTN, RCC1, VIM, CHAF1A, RB1, CHAF1B, RAF1, EP300, CFTR, NEDD9, GFAP, BCL2L1, LIMK1, WAS, NLGN1, RBL1, ASF1A, PEX6, PAK1, HIST3H3, FMNL1, HDAC6, ERCC4, ATG12, NCOR1, BMI1, DFFB, WIPF1, PCLO, ABLIM3, SYNPO, FOXL2, BUB1B, PRKG1, SNAP91, SETDB1, TP53, NPHP1, ACTC1, TUBB, AKT1, TNNT2, ATG5, NCK1, PEX19, KIF5A, HDAC1, TLN1, SHANK1, APBB1, TUBA4A, RHOA, SGCG, RAC3, RAC1, HDAC4, WRN, KIFAP3, ACTN1, CRYAA, MICAL1, 652 1195 15360 1.8728341504735988 1.4488227080500238E-5 1.957882516112619E-7 5.275211190092222E-6 GOTERM_BP_ALL GO:0003015~heart process 14 0.27% 1.3595722660364772E-7 RYR2, PRKCA, ACTC1, TNNT2, CSRP3, ADRBK1, CACNA1B, SCN5A, S100A1, CUGBP2, CACNA1C, PLN, KCNJ12, ADRB2, 652 51 15360 6.466979429808734 7.140642517446949E-4 6.377830706671972E-6 2.6008380007436216E-4 GOTERM_BP_ALL GO:0048856~anatomical structure development 196 3.71% 3.1654919369839672E-27 KIT, MAFK, CAPN3, KCNJ8, FGF8, GATA4, LLGL1, BAI1, NFKBIA, IRS2, FYN, RAG1, S100A7, PLCE1, POU1F1, BMX, ADRBK1, FOXH1, POU3F3, NTS, GCM1, CLTCL1, NEDD9, NLGN1, ITGB2, MPZ, PTPN11, FOXL2, GJA1, AGTR2, UBB, RELB, JUN, EPHA2, PTPRZ1, FGF1, PICK1, CD2, PAX3, CAV1, ATP2B2, IL4, BCL10, MAPK1, DCN, IL27RA, EDA2R, CDK5R1, SMARCA4, HOXC8, NR5A1, PMP22, CRKL, NRXN2, RNF2, EPHB1, SH3GL3, ZBTB16, TRPC5, CD74, RB1, APP, CCR4, PTGS2, EP300, SNTG2, LMO2, BMP1, WAS, KNG1, DLX5, PITX2, IGF1R, BMPR1A, TWIST1, STAT3, CASP8, SALL1, CHRM3, TH, ERC2, PAX5, BICD1, PKP2, SFRP1, CDKN1C, CHAT, SIAH1, NTRK1, SMAD2, PRKG1, SETDB1, HCK, ACTC1, ZEB2, GATA2, HAND2, CUGBP2, SIX1, POU3F2, RAC1, BDNF, HDAC4, PLN, SOX10, XAB2, F11R, CAV3, PLG, HDAC5, ERCC3, MARK4, WNT1, MAP3K7, LAMA3, ALK, DLG4, WNT2, TGM2, CLASP2, PPARA, TTN, CEBPE, DAG1, FOS, PARK2, BRSK2, SMAD1, TCF3, IGFBP3, EYA1, CFTR, ADRB2, FGF7, PLP1, NOV, CSRP3, TP73, FGF2, BMI1, MAP3K7IP1, AR, MCF2, GNA12, ERCC2, FRS2, AKT1, CTGF, GJA8, SGCG, RAC3, SMAD3, EPHB2, FGFR1, NAIP, GNAQ, ETS1, PSEN1, MYF5, FZD1, RHOH, EGFR, RND1, HEYL, SMAD4, NOTCH4, PPP3R1, ZAP70, CASP3, NDN, PIK3R1, VHL, CSPG4, LRP2, MYOG, NHLH1, MYT1, CD44, CTNNB1, LIMK1, MYOD1, PARD6B, RAG2, TP53, SH3GL2, PKD1, RELA, ALPL, NCK1, SIX3, HAND1, APBB1, ZNF423, PKD2, PARD3, NTRK2, 652 2153 15360 2.1446462205682466 1.6631494636913765E-23 1.3859578864094803E-24 6.0555382555798106E-24 GOTERM_BP_ALL GO:0003013~circulatory system process 26 0.49% 3.7444207108004097E-8 KCNJ8, PRKCA, KNG1, CSRP3, SCN5A, MEOX2, NFE2, KCNJ12, RYR2, AGTR2, WNT2, ACTC1, TNNT2, REN, CACNA1B, ADRBK1, S100A1, CUGBP2, CACNA1C, CAV1, CHGA, PTGS2, PLN, NTS, CFTR, ADRB2, 652 167 15360 3.667756511516844 1.9671251717523486E-4 2.09289001862345E-6 7.163017815559058E-5 GOTERM_BP_ALL GO:0003012~muscle system process 19 0.36% 2.6050015079143315E-4 PRKG1, RYR2, GJA1, DTNA, PRKCA, PDE4D, KNG1, ACTC1, VIPR1, NOS1, TNNT2, TTN, SCN5A, DAG1, CHRM3, PLN, KCNJ12, ADRB2, PLCE1, 652 167 15360 2.680283604570001 0.7455996552345721 0.006376063156316669 0.49715783145843906 GOTERM_BP_ALL GO:0000079~regulation of cyclin-dependent protein kinase activity 9 0.17% 0.0012651444649079498 CDC25A, CDK5R2, GTF2H1, CHEK1, CASP3, CDKN1C, CDKN3, CDC37, CDK5R1, 652 51 15360 4.1573439191627575 0.998707629719277 0.02574620597675603 2.3926457948698077 GOTERM_BP_ALL GO:0003008~system process 100 1.90% 1.4991040784912608E-6 KCNJ8, VIPR1, HAP1, NOS1, CRY1, MEOX2, PDC, PPEF1, ERCC3, PLCE1, DLG4, AXIN1, WNT2, ARRB2, TTN, CACNA1B, ADRBK1, SNPH, DAG1, S100A1, PARK2, CAMK4, NTS, EYA1, CFTR, ADRB2, RHO, PHOX2A, NLGN1, SLC6A4, GRM1, SNCAIP, PLP1, CSRP3, MPZ, PTPN11, PPEF2, ERCC2, GJA1, AGTR2, UBB, DLG2, KCNV2, TNNT2, ARRB1, REN, GJA8, SNAP25, GABARAPL2, PAX3, ATP2B2, CAV1, CACNA1C, RAC3, CRYAA, GNAQ, OPRD1, MAPK1, LIN7A, KIFC3, KCNJ12, PMP22, GJA3, SNCB, NRXN2, NDN, APP, MITF, CHGA, AKAP9, PTGS2, SAG, GPR143, CTNNB1, SLC6A1, DTNA, PRKCA, KNG1, SCN5A, CHRM3, TH, CHAT, NFE2, PCLO, PRKG1, RYR2, OPRL1, STX1A, NPHP1, PDE4D, ACTC1, KIF5A, SIX3, CUGBP2, C5AR1, SIX1, PLN, PKD2, SOX10, TRPV1, 652 1461 15360 1.6124765372066363 0.007845361967167563 5.625769413619697E-5 0.0028677244853891892 GOTERM_BP_ALL GO:0003002~regionalization 19 0.36% 9.162420032118999E-7 FRS2, RNF2, SMAD2, CTNNB1, ZEB2, FGF1, BMPR1A, MEOX1, FOXH1, MEOX2, MYF5, BMI1, FGF2, SFRP1, HOXB6, EP300, CRKL, MDFI, SMAD4, 652 111 15360 4.032498756425136 0.004802369262586814 3.619436519342045E-5 0.001752742552985076 GOTERM_BP_ALL GO:0000075~cell cycle checkpoint 10 0.19% 0.001134045517372565 BUB1B, RB1, ATR, CHEK1, CDC45L, ERCC3, CDC2, TP53, PTPN11, ERCC2, 652 62 15360 3.7997229368691863 0.9974243572961802 0.02328839859017562 2.1472540607951007 GOTERM_BP_ALL GO:0000074~regulation of progression through cell cycle 65 1.23% 1.909740057490411E-14 CD28, CDC25A, BCL10, CDK5R2, RAP1A, FGF8, CDC37, CALR, CDC14A, CDK5R1, STAT1, CDK3, HDAC5, ERCC3, EGFR, CDKN3, AXIN1, ANAPC10, CASP3, APC2, NDN, VHL, RCC1, RB1, CHEK1, SRPK1, DUSP6, NEDD9, ADCYAP1, GTF2H1, CYLD, PRKCA, CDC2, MDM4, FGF7, IGF1R, RBL1, TP73, FRK, FGF2, PTPN11, CDKN1C, ERCC2, MYC, BUB1B, CDC45L, TP53, ZMYND11, TFDP2, E2F2, STARD13, FGF1, STK11, APBB1, TSC2, ATR, MDM2, HIC1, GADD45G, COPS5, PKD2, EPHB2, WT1, MAPK3, PLEKHO1, 652 526 15360 2.9111945695024373 1.0032952246774585E-10 2.2801760479751465E-12 3.652633751016765E-11 GOTERM_BP_ALL GO:0006974~response to DNA damage stimulus 26 0.49% 0.002915318841231618 GTF2H1, MAPK1, CDC2, MCM7, ASF1A, CRY1, PARP1, ERCC4, ERCC3, HMGB1, TP73, PTPN11, PRKCG, ERCC2, XPA, TP53, CHAF1A, CHEK1, ATR, FANCA, CHAF1B, RAD52, GADD45G, XAB2, VCP, CSNK1E, 652 324 15360 1.8904794364917064 0.9999997821492789 0.05387170114486639 5.4320025463227894 GOTERM_BP_ALL GO:0043412~biopolymer modification 157 2.98% 1.0353377677884643E-17 KIT, PPP5C, SRC, UBE2O, CDC14A, CRY1, JAK1, STAT1, PARP1, TNFRSF14, MAP2K7, CDK3, TEK, PPEF1, MARK4, FYN, CDKN3, PRKCG, MAP3K7, ATG7, PLAT, PRKCD, ALK, AKT2, ABL2, NUAK1, WNT2, TGM2, MARK3, PRKD3, PTK2, DUSP22, OTUD7B, PTPN7, TTN, BMX, IL12A, ADRBK1, UBE2I, PARK2, FOS, CHEK1, MAP3K14, SRPK1, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, USP2, CSNK1E, DUSP6, CFTR, CYLD, CASK, RHO, PTPRG, MAP3K3, ITGB2, CSNK1A1, MAP3K5, CTBP1, CSNK2A1, ATG12, FRK, BMI1, FGF2, PTPN11, PPEF2, MAPK14, UBB, APOBEC1, VCPIP1, JUN, AKT1, EPHA2, PTPRZ1, RPS6KA1, HDAC1, PICK1, IL4, STUB1, TGFBR1, GNA14, MAPK8, EPHB2, MAPK3, FGFR4, TNK2, CDC25A, FGFR1, BCL10, GSK3A, GNAQ, MAPK1, MARK1, PSEN1, CREBBP, PTPN21, EGFR, USP9X, CRKL, BCR, PPM1A, RNF2, ZAP70, ANAPC10, MAP3K4, EPHB1, ZBTB16, PIK3R1, VHL, PRKAA1, LRP2, PAK7, GUCY2C, RAF1, CAMK2A, MYT1, EP300, NEDD4, FES, PRKCA, LIMK1, PFTK1, CDC2, LIPE, MYOD1, PRKAR2A, IGF1R, BMPR1A, PAK1, CHRM3, HDAC6, STAMBPL1, PTPRM, FER, SIAH1, NTRK1, PTPRN, BUB1B, PRKG1, TRAF6, PTPRS, HCK, TP53, MAPKAPK2, LMTK2, STK11, CSF1R, PKN1, MDM2, MAP3K8, VCP, NTRK2, ERC1, MYLK, 652 1877 15360 1.9705116178734503 5.4396646319605915E-14 1.6998951974876848E-15 1.980585509329448E-14 GOTERM_BP_ALL GO:0006968~cellular defense response 10 0.19% 0.004317250462531865 NCF2, BCL10, SH2D1A, C5AR1, MNDA, CCL5, CCR3, IL4, RELA, FOSL1, 652 75 15360 3.1411042944785277 0.9999999998658334 0.07368276380752703 7.943451599064422 GOTERM_BP_ALL GO:0043408~regulation of MAPKKK cascade 5 0.09% 0.003870209549245147 CARD9, CAV3, GRM1, REN, ADRB2, 652 16 15360 7.361963190184049 0.9999999985813092 0.0671718041729652 7.149560353280238 GOTERM_BP_ALL GO:0046209~nitric oxide metabolic process 6 0.11% 0.004222563757477312 CAV1, PTX3, HSP90AA1, NOS1, EGFR, AKT1, 652 26 15360 5.436526663520529 0.9999999997788813 0.0725939678284876 7.77583822283352 GOTERM_BP_ALL GO:0043406~positive regulation of MAP kinase activity 15 0.28% 7.754752121912109E-7 KIT, FRS2, GRM1, PRKAA1, GAB1, MAP3K5, DAXX, PKN1, C5AR1, FGF2, PTPN11, EGFR, MDFI, PLCE1, ADRB2, 652 68 15360 5.196679898953446 0.004066059448333492 3.134064998266961E-5 0.0014834619378456537 GOTERM_BP_ALL GO:0043405~regulation of MAP kinase activity 19 0.36% 1.325322719052463E-7 FRS2, KIT, PRKCA, DUSP22, GRM1, PRKAA1, GAB1, MAP3K5, DAXX, PKN1, C5AR1, CAV1, FGF2, PTPN11, EGFR, DUSP6, MDFI, ADRB2, PLCE1, 652 98 15360 4.567422060848879 6.960822251728116E-4 6.33020362683645E-6 2.5353192950605674E-4 GOTERM_BP_ALL GO:0006959~humoral immune response 10 0.19% 0.003595558301284955 CD28, EBI3, SH2D1A, PAX5, C1QA, MBL2, BMI1, POU2AF1, RFXANK, CD46, 652 73 15360 3.2271619463820493 0.9999999939614801 0.06381403252054463 6.658599385499886 GOTERM_BP_ALL GO:0006954~inflammatory response 34 0.64% 5.737627991609165E-7 CXCL2, CCL7, PRKCA, C1QA, NMI, KNG1, CCR3, MEFV, CD46, ITGB2, STAT3, CCL13, HDAC5, PTX3, CCL5, MBL2, CCL17, MIF, CCL8, TGM2, CCR1, AKT1, RELA, IL8RA, FOS, FABP4, CCR4, SELE, RAC1, TNFRSF1B, HDAC4, PTGS2, F11R, ADRB2, 652 301 15360 2.6610684222326397 0.003010011416271885 2.392471865342305E-5 0.001097593858456758 GOTERM_BP_ALL GO:0006952~defense response 51 0.97% 1.2431368189082933E-6 CXCL2, BCL10, DNAJC3, MNDA, IL27RA, ANKRD1, SH2D1A, HDAC5, PTX3, MBL2, DEFB1, S100A7, CCL8, TGM2, CCR1, FOSL1, IL8RA, CEBPE, IL12A, NCF2, FOS, CCR4, PTGS2, ADRB2, CCL7, PRKCA, C1QA, WAS, KNG1, NMI, CCR3, MEFV, CD46, ITGB2, STAT3, CCL13, CCL5, MIF, CCL17, TUBB, RELA, AKT1, C5AR1, FABP4, SELE, RAC1, TNFRSF1B, HDAC4, APOH, IL4, F11R, 652 577 15360 2.0822745106378453 0.006510161382709212 4.7673643914336594E-5 0.002378075156517223 GOTERM_BP_ALL GO:0006950~response to stress 95 1.80% 1.2793838123942686E-11 CXCL2, HSF1, DNAJC3, GNAQ, MAPK1, HSPA5, CREBBP, CRY1, ATOX1, PLG, PARP1, MAP2K7, HDAC5, ERCC3, HMGB1, PTX3, MBL2, EGFR, PRKCG, PLAT, S100A7, XPA, CCL8, TGM2, CASP3, MAP3K4, HSP90AA1, CCR1, PPARA, IL8RA, VHL, TTN, PRKAA1, CHAF1A, FOS, CHEK1, CHAF1B, CCR4, HIF1A, PTGS2, EP300, CSNK1E, ADRB2, GTF2H1, CCL7, PRKCA, CDC2, C1QA, NMI, KNG1, WAS, MCM7, CCR3, FGF7, MEFV, CD46, ASF1A, ITGB2, STAT3, GAB1, CCL13, MAP3K5, ERCC4, TP73, INSIG2, CCL5, CCL17, PTPN11, MIF, MAPK14, GNA12, ERCC2, RAG2, TP53, CTSB, AKT1, RELA, CTGF, SMAD7, PLAU, ATR, FABP4, FANCA, RAC1, SELE, RAD52, HDAC4, TNFRSF1B, GADD45G, APOH, XAB2, F11R, MAPK8, TRPV1, VCP, 652 1081 15360 2.0703393245290944 6.721902789941225E-8 1.13930564982212E-9 2.4474489102033203E-8 GOTERM_BP_ALL GO:0019725~cellular homeostasis 30 0.57% 6.691946932128319E-5 TXN, CCL7, BCL2L1, PRKCA, CAV3, KNG1, CCR3, CALR, CSRP3, CCL13, ATOX1, PLG, CCL5, ATP7B, MYC, PLCE1, RYR2, CP, OPRL1, TGM2, SLC9A3R1, CCR1, IREB2, APP, C5AR1, CACNA1C, ATP2B2, CCR4, PLN, PKD2, 652 313 15360 2.2579823203120406 0.2964431930241629 0.0018201376849182882 0.12793830653263782 GOTERM_BP_ALL GO:0006936~muscle contraction 19 0.36% 2.6050015079143315E-4 PRKG1, RYR2, GJA1, DTNA, PRKCA, PDE4D, KNG1, ACTC1, VIPR1, NOS1, TNNT2, TTN, SCN5A, DAG1, CHRM3, PLN, KCNJ12, ADRB2, PLCE1, 652 167 15360 2.680283604570001 0.7455996552345721 0.006376063156316669 0.49715783145843906 GOTERM_BP_ALL GO:0006935~chemotaxis 24 0.45% 7.363903613308085E-8 CXCL2, CCL8, CCL7, PRKCA, MAPK1, DOCK2, CCR1, CCR3, FOSL1, IL8RA, ITGB2, CCL13, RALA, PLAU, C5AR1, CCR4, CCL5, CCL17, FGF2, IL4, MAPK14, FER, DEFB1, IL16, 652 149 15360 3.794622637625067 3.868246739046066E-4 3.7201806749598276E-6 1.408702695715469E-4 GOTERM_BP_ALL GO:0035150~regulation of tube size 8 0.15% 0.0017593250816535133 WNT2, AGTR2, KCNJ8, CAV1, KNG1, NTS, ADRB2, CFTR, 652 42 15360 4.4872918492550395 0.999904045331765 0.034695402878536896 3.312423205285242 GOTERM_BP_ALL GO:0015674~di-, tri-valent inorganic cation transport 17 0.32% 8.409845153877279E-4 RYR2, CCL8, GJA1, TRPC4, ACCN2, CAV3, TRPC5, CACNA1B, ITPR1, TRPV6, ATP2B2, CACNA1C, FYN, PLN, PKD2, TRPV1, ADRB2, 652 154 15360 2.600589594454625 0.9879704799387344 0.01780859062783202 1.596584815286084 GOTERM_BP_ALL GO:0006928~cell motility 45 0.85% 3.090480150176828E-8 TXN, PRKCA, LIMK1, PSEN1, PARD6B, TWIST1, ITGB2, CDK5R1, STAT3, GAB1, PLG, FYN, CCL5, WNT1, EGFR, WASL, MAPK14, SIAH1, CRKL, IL16, LAMA3, MSN, PRKG1, LAMA1, WNT2, UBB, DOCK2, TUBB, NDN, NCK1, CTGF, ARHGDIB, ZEB2, VIM, IL12A, TLN1, CSPG4, SIX1, CCR4, RAC1, PTGS2, ACTN1, F11R, MAPK8, CFTR, 652 421 15360 2.518106174314734 1.6236064765073888E-4 1.8244233870312598E-6 5.912040182964873E-5 GOTERM_BP_ALL GO:0048747~muscle fiber development 10 0.19% 2.2003240828777143E-4 APP, PLG, CUGBP2, UBB, SIX1, ACTC1, CHAT, MYOD1, IGFBP3, TTN, 652 50 15360 4.711656441717791 0.6853132174856704 0.005464528950115843 0.4200801721966574 GOTERM_BP_ALL GO:0006917~induction of apoptosis 22 0.42% 2.887269859529302E-4 BAD, TGM2, PRKCA, MAPK1, IKBKG, CASP3, TP53, TUBB, CASP6, IL12A, MAP3K5, DAXX, TNFRSF25, PLG, TRAIP, CD2, ERCC3, TP73, TRAF3, SMAD3, FOXL2, ERCC2, 652 213 15360 2.433249805581958 0.7806728047010685 0.006872595955750294 0.5508871351149747 GOTERM_BP_ALL GO:0006916~anti-apoptosis 23 0.44% 2.7676787576154195E-6 CD28, NAIP, TGM2, HSPA5, BCL2L1, CDC2, SERPINB2, AKT1, NOL3, RELA, VHL, IGF1R, PRKAA1, HDAC1, PSEN1, YWHAZ, PAK7, HMGB1, SFRP1, CRYAA, CASP2, BAG4, ERC1, 652 169 15360 3.206156750281337 0.014436188707416031 9.82479052199503E-5 0.005294394821830917 GOTERM_BP_ALL GO:0048741~skeletal muscle fiber development 10 0.19% 2.2003240828777143E-4 APP, PLG, CUGBP2, UBB, SIX1, ACTC1, CHAT, MYOD1, IGFBP3, TTN, 652 50 15360 4.711656441717791 0.6853132174856704 0.005464528950115843 0.4200801721966574 GOTERM_BP_ALL GO:0006915~apoptosis 97 1.84% 1.0737749748908946E-21 HSPA5, IKBKG, GZMB, NFKBIA, STAT1, PLG, TNFRSF25, TNFRSF14, ERCC3, HMGB1, RYBP, MAP3K7, AXIN1, TGM2, DUSP22, NOL3, DFFA, IL12A, EIF5A, TRAF3, IGFBP3, CASP5, ADRB2, SERPINB2, ITGB2, MAP3K5, ATG12, TP73, FOXL2, CASP2, ERCC2, GJA1, AGTR2, TUBB, E2F2, CTSB, ATG5, AKT1, HDAC1, CD2, PAX3, SMAD3, GADD45G, TNFRSF1B, WRN, ACTN1, IL4, MAPK8, CRYAA, CD28, BCL10, NAIP, MAPK1, CALR, PSEN1, CDK5R1, TRAF5, SEPT4, BAD, CASP3, PIK3R1, ZBTB16, VHL, PRKAA1, CD74, APP, TRAIP, EAF2, PAK7, RAF1, EP300, BAG4, BCL2L1, PRKCA, CDC2, KNG1, MDM4, CASP6, IGF1R, PAK1, CASP8, RABEP1, MIF, SFRP1, DFFB, SIAH1, BUB1B, TRAF6, CARD9, TP53, ACTC1, RELA, TRAF1, DAXX, YWHAZ, VCP, ERC1, 652 784 15360 2.9147364467259296 5.6416137180767605E-18 2.256645487230704E-19 2.0541153058602772E-18 GOTERM_BP_ALL GO:0031325~positive regulation of cellular metabolic process 47 0.89% 2.545795729916538E-9 TNK2, CD28, CTNNB1, BCL10, GTF2H1, PRKCA, GATA4, ASF1A, CREBBP, ERCC3, TP73, FGF2, EGFR, FOXL2, NR5A1, PRKCG, SMAD4, ERCC2, NOTCH4, SMAD2, UBB, POU1F1, TP53, JUN, PPARA, FOSL1, RELA, PRKAA1, IL12A, HAND1, HAND2, EBI3, RB1, FOXH1, APP, MYOG, ZNF423, TGFB1I1, SMAD3, HIF1A, TCF3, SOX10, IL4, SMAD1, EP300, NCOA2, ADRB2, 652 416 15360 2.6616328456819254 1.3375521094927123E-5 1.8322752493027394E-7 4.870068570639319E-6 GOTERM_BP_ALL GO:0031324~negative regulation of cellular metabolic process 43 0.81% 2.196681498354111E-8 SERPINA5, CTNNB1, PRKCA, MDM4, PER1, RBL1, TWIST1, STAT3, ORC2L, HDAC5, SMARCA4, HMGB1, FZD1, NCOR1, BMI1, RYBP, CDKN1C, SMAD4, RNF2, CBX2, CDC45L, TP53, ZMYND11, ZBTB16, JUN, VHL, ZEB2, MBD2, PRKAA1, HAND1, SIX3, RB1, DAXX, APBB1, ATR, MDM2, ZNF423, FABP4, SMAD3, HDAC4, IGFBP3, MDFI, NCOA2, 652 387 15360 2.6175869120654394 1.1540698755552192E-4 1.3265927689687373E-6 4.202217694926347E-5 GOTERM_BP_ALL GO:0031323~regulation of cellular metabolic process 176 3.34% 1.0655790191503746E-7 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, PRKCG, POU1F1, PPARA, RFXANK, IL12A, CEBPE, EIF5A, FOXH1, EBI3, SRY, POU3F3, FOS, CHAF1B, HOXD4, SRPK1, TCF3, SMAD1, IGFBP3, EYA1, GCM1, ETF1, ADRB2, GTF2H1, MAX, PHOX2A, MCM7, ASCC2, ASF1A, ITGB2, ORC2L, TP73, BMI1, FGF2, AR, FOXL2, CLIP1, ERCC2, HOXB9, UBB, RELB, ATF7IP2, E2F2, JUN, AKT1, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, ATR, DACH1, FABP4, SMAD3, TNFRSF1B, IL4, STUB1, TGFBR1, SREBF2, TNK2, CD28, KPNA2, BCL10, ETS1, CALR, PSEN1, CREBBP, ANKRD1, MSC, EDA2R, MYF5, SMARCA4, FZD1, PLAG1, RHOH, TRIP4, HOXC8, EGFR, WASL, HEYL, NR5A1, SMAD4, NOTCH4, RNF2, CBX2, DBP, TCEA2, ZBTB33, ZBTB16, NDN, FOSL1, TAF13, VHL, PRKAA1, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, EP300, MDFI, CTNND1, SERPINA5, CTNNB1, ASCC3, PRKCA, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, PAX5, NCOR1, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, CDC45L, MEIS1, TP53, MAPKAPK2, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, APBB1, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, SOX10, WT1, NCOA2, ERC1, 652 2873 15360 1.4431805320959472 5.59698556949817E-4 5.183831440325193E-6 2.0384345978952112E-4 GOTERM_BP_ALL GO:0043285~biopolymer catabolic process 27 0.51% 0.002966225273401377 MMP13, CYLD, MDM4, GSPT2, ERCC4, ERCC3, DFFB, USP9X, PRKCG, FOXL2, SIAH1, ERCC2, AXIN1, GJA1, MMP1, ANAPC10, UBB, AKT1, RELA, DFFA, UBE2I, PARK2, MDM2, STUB1, MMP3, USP2, VCP, 652 342 15360 1.8598643848886016 0.999999833406152 0.0538427323236248 5.52432245464809 GOTERM_BP_ALL GO:0048732~gland development 8 0.15% 0.005438281965099774 NOTCH4, SIX1, POU1F1, POU3F2, AR, NR5A1, CRKL, GATA2, 652 51 15360 3.695416817033562 0.9999999999996393 0.08882634921002885 9.906072775074758 GOTERM_BP_ALL GO:0043283~biopolymer metabolic process 320 6.06% 3.020032995838153E-14 KIT, HSF1, PPP5C, MAFK, MNDA, GATA4, POU2AF1, CRY1, STAT1, MAP2K7, CDK3, HMGB1, TFCP2, PPEF1, FYN, PPP1R3A, PRM1, RAG1, PRKCG, ATG7, PLAT, PRKCD, ABL2, POU1F1, PRKD3, DUSP22, OTUD7B, PTPN7, RFXANK, DFFA, RCC1, BMX, ADRBK1, FOXH1, SRY, POU3F3, CHEK1, MAP3K14, SRPK1, USP2, GCM1, MMP13, GTF2H1, CYLD, MAX, PHOX2A, RHO, MCM7, PTPRG, MAP3K3, ITGB2, HIST3H3, CSNK1A1, MAP3K5, CTBP1, GSPT2, CSNK2A1, PTPN11, PPFIBP2, PPEF2, FOXL2, CLIP1, HOXB9, GJA1, UBB, RELB, RFXAP, APOBEC1, ATF7IP2, E2F2, JUN, ZNF208, EPHA2, MBD2, PTPRZ1, HOXB7, PICK1, GTF2F2, PAX3, GADD45G, TNFRSF1B, WRN, IL4, STUB1, TGFBR1, MMP3, SREBF2, FGFR4, CDC25A, BCL10, KPNA2, GSK3A, MAPK1, IL27RA, CBX5, SMARCA4, U2AF2, HOXC8, USP9X, WASL, NR5A1, CRKL, PPM1A, RNF2, CBX2, DBP, ANAPC10, TCEA2, EPHB1, ZBTB16, FOSL1, TAF13, RB1, APP, PAK7, GUCY2C, RAF1, EP300, MDFI, CTNND1, CDC2, LIPE, DLX5, PITX2, MDM4, PRKAR2A, IGF1R, BMPR1A, TWIST1, STAT3, SALL1, CHRM3, HDAC6, BICD1, PAX5, DFFB, CDKN1C, FER, SIAH1, NTRK1, PTPRN, SMAD2, PRKG1, MMP1, SETDB1, HCK, ZEB2, GATA2, HAND2, SMAD7, DAXX, CUGBP2, MDM2, FANCA, SIX1, MAP3K8, POU3F2, TGFB1I1, HDAC4, SOX10, XAB2, WT1, MYLK, IKBKG, SRC, PER1, MEOX1, UBE2O, CDC14A, MEOX2, JAK1, YBX1, PARP1, TNFRSF14, HDAC5, TEK, ERCC3, MARK4, SFRS2IP, RYBP, CDKN3, MAP3K7, ALK, AXIN1, AKT2, NUAK1, WNT2, TGM2, MARK3, PTK2, NOL3, PPARA, TTN, IL12A, CEBPE, UBE2I, PARK2, FOS, CHAF1B, HOXD4, PPP2R2A, BRSK2, CAMK4, TCF3, SMAD1, IGFBP3, PRKACA, EYA1, CSNK1E, DUSP6, ADRB2, CFTR, CASK, NMI, ASCC2, ASF1A, ORC2L, ERCC4, ATG12, TP73, FRK, BMI1, FGF2, MAPK14, AR, ERCC2, VCPIP1, AKT1, CTGF, RPS6KA1, HDAC1, ATR, DACH1, SMAD3, GNA14, MAPK8, EPHB2, MAPK3, TNK2, FGFR1, GNAQ, MARK1, ETS1, CALR, PSEN1, CREBBP, ANKRD1, MSC, MYF5, PTPN21, PLAG1, TRIP4, EGFR, HEYL, SMAD4, BCR, NOTCH4, XPA, ZAP70, MAP3K4, ZBTB33, PIK3R1, NDN, VHL, PRKAA1, CHAF1A, HOXA9, EAF2, LRP2, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, NEDD4, FES, CTNNB1, ASCC3, PRKCA, LIMK1, PFTK1, MYOD1, RBL1, PAK1, STAMBPL1, NCOR1, PTPRM, NFE2, MYC, MIZF, BUB1B, RAG2, TRAF6, MLLT1, PTPRS, CDC45L, MEIS1, TP53, MAPKAPK2, ZMYND11, TFDP2, RELA, HAND1, SIX3, LMTK2, STK11, CSF1R, PKN1, ZNF423, ASCC1, HIC1, RAD52, COPS5, VCP, NCOA2, NTRK2, ERC1, 652 5361 15360 1.4062022583004041 1.5866064018155157E-10 3.3054670112164786E-12 5.7764903971246895E-11 GOTERM_BP_ALL GO:0048731~system development 166 3.15% 3.0681828743743237E-24 KIT, CAPN3, MAFK, KCNJ8, CAV3, GATA4, NFKBIA, BAI1, PLG, IRS2, HDAC5, ERCC3, MARK4, FYN, WNT1, RAG1, MAP3K7, S100A7, LAMA3, DLG4, ALK, PLCE1, WNT2, TGM2, POU1F1, PPARA, TTN, BMX, CEBPE, ADRBK1, FOXH1, POU3F3, PARK2, FOS, BRSK2, TCF3, SMAD1, IGFBP3, GCM1, ADRB2, CFTR, NLGN1, FGF7, PLP1, CSRP3, MPZ, TP73, BMI1, FGF2, PTPN11, MAP3K7IP1, AR, FOXL2, MCF2, ERCC2, FRS2, GJA1, UBB, RELB, AKT1, EPHA2, CTGF, FGF1, PTPRZ1, GJA8, PICK1, PAX3, CD2, SGCG, ATP2B2, SMAD3, IL4, EPHB2, FGFR1, BCL10, NAIP, GNAQ, MAPK1, DCN, ETS1, IL27RA, PSEN1, EDA2R, CDK5R1, MYF5, SMARCA4, RHOH, HOXC8, EGFR, RND1, HEYL, NR5A1, CRKL, PMP22, SMAD4, NRXN2, NOTCH4, PPP3R1, ZAP70, CASP3, EPHB1, ZBTB16, SH3GL3, PIK3R1, NDN, TRPC5, CD74, CSPG4, RB1, APP, LRP2, MYOG, CCR4, NHLH1, PTGS2, MYT1, SNTG2, EP300, CD44, LMO2, BMP1, CTNNB1, LIMK1, WAS, DLX5, PITX2, MYOD1, IGF1R, BMPR1A, PARD6B, TWIST1, CASP8, STAT3, SALL1, CHRM3, ERC2, PAX5, PKP2, CHAT, CDKN1C, SIAH1, NTRK1, SMAD2, RAG2, PRKG1, HCK, SH3GL2, ACTC1, ALPL, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, CUGBP2, APBB1, ZNF423, SIX1, POU3F2, BDNF, HDAC4, PLN, PKD2, PARD3, NTRK2, 652 1760 15360 2.2219743446737312 1.6120232821962695E-20 8.484333064190893E-22 5.869387488818186E-21 GOTERM_BP_ALL GO:0014706~striated muscle development 22 0.42% 1.1449130836058916E-9 UBB, ACTC1, MYOD1, TTN, TWIST1, CSRP3, RB1, APP, CUGBP2, PLG, HDAC5, MYOG, MYF5, SIX1, SMAD3, HDAC4, PLN, CHAT, FOXL2, IGFBP3, EP300, ADRB2, 652 101 15360 5.1315070157322475 6.01535509292539E-6 8.472356238797829E-8 2.1902013536134746E-6 GOTERM_BP_ALL GO:0006897~endocytosis 18 0.34% 0.004349834579338615 SYNJ1, VAV1, SH3GL2, SH3GL3, SYP, CEBPE, GATA2, SNX17, LRP1, RABEP1, CUBN, APP, LRP2, TSC2, PTX3, RAC1, ADRB2, CLTCL1, 652 197 15360 2.1525333997695495 0.999999999887028 0.07397927323852616 8.001064848279693 GOTERM_BP_ALL GO:0006887~exocytosis 12 0.23% 0.00336311427697667 SNPH, SNAP25, EXOC2, CCL8, STX1A, TRPV6, STXBP1, LIN7A, CCL5, NLGN1, PCLO, EXOC3, 652 100 15360 2.826993865030675 0.9999999794330822 0.06001057170988244 6.2411659467159435 GOTERM_BP_ALL GO:0048699~generation of neurons 36 0.68% 2.177623553505998E-8 GNAQ, LIMK1, DLX5, NLGN1, BAI1, PSEN1, PARD6B, TWIST1, CDK5R1, FYN, PTPN11, HOXC8, CHAT, CDKN1C, RND1, SIAH1, MCF2, FRS2, PRKG1, GJA1, WNT2, UBB, NDN, EPHA2, PTPRZ1, GATA2, APP, PICK1, APBB1, SIX1, CCR4, ATP2B2, POU3F2, BRSK2, PARD3, CFTR, 652 289 15360 2.9345957076442994 1.1440579762311831E-4 1.3303751902338234E-6 4.1657601290712165E-5 GOTERM_BP_ALL GO:0006878~cellular copper ion homeostasis 4 0.08% 0.003616690676854533 ATOX1, APP, CP, ATP7B, 652 8 15360 11.77914110429448 0.9999999945982251 0.06396189335854363 6.696462385927693 GOTERM_BP_ALL GO:0006875~cellular metal ion homeostasis 20 0.38% 2.3288281802794952E-6 RYR2, OPRL1, TGM2, CCL7, PRKCA, KNG1, CCR3, CCR1, CALR, CSRP3, CCL13, C5AR1, ATP2B2, CACNA1C, CCR4, CCL5, PLN, PKD2, ATP7B, PLCE1, 652 130 15360 3.624351109013686 0.012161125977267928 8.496637283861297E-5 0.004454919081220421 GOTERM_BP_ALL GO:0006874~cellular calcium ion homeostasis 20 0.38% 7.636523707701424E-7 RYR2, OPRL1, TGM2, CCL7, PRKCA, KNG1, CCR3, CCR1, CALR, CSRP3, CCL13, C5AR1, ATP2B2, CACNA1C, CCR4, CCL5, PLN, PKD2, ATP7B, PLCE1, 652 121 15360 3.8939309435684226 0.004004192842943954 3.1102082894363114E-5 0.0014608453364539642 GOTERM_BP_ALL GO:0006873~cellular ion homeostasis 28 0.53% 3.944794817492495E-7 CCL7, BCL2L1, PRKCA, CAV3, KNG1, CCR3, CALR, CSRP3, CCL13, ATOX1, CCL5, ATP7B, PLCE1, MYC, RYR2, CP, OPRL1, TGM2, SLC9A3R1, CCR1, IREB2, APP, C5AR1, CACNA1C, ATP2B2, CCR4, PLN, PKD2, 652 214 15360 3.0823920646751906 0.0020704492627128257 1.7271480895364455E-5 7.546305908268103E-4 GOTERM_BP_ALL GO:0043170~macromolecule metabolic process 389 7.37% 2.7836748448349955E-11 KIT, SLC2A2, PPP5C, CAPN3, CDC37, CRY1, IRS2, CDK3, TFCP2, HMGB1, PPP1R3A, FYN, RAG1, PRKCG, ATG7, ABL2, PRKD3, DUSP22, RFXANK, DFFA, RCC1, MAP3K14, GCM1, CLTCL1, MMP13, GTF2H1, CYLD, MAX, ITGB2, MAP3K5, CSNK1A1, CTBP1, PPEF2, CLIP1, HOXB9, UBB, RELB, TUBB, E2F2, ATF7IP2, CTSB, JUN, PTPRZ1, HOXB7, PICK1, PAX3, TSC2, CAV1, STUB1, TGFBR1, MMP3, FGFR4, CDC25A, BCL10, IL27RA, SMARCA4, U2AF2, NR5A1, CBX2, RNF2, PPM1A, ANAPC10, HSP90AA1, FOSL1, TAF13, RB1, PAK7, EP300, BAG4, TRPC4, WAS, LIPE, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, CDKN1C, PTPRN, PRKG1, SETDB1, ZEB2, GATA2, DAXX, CUGBP2, MAP3K8, TGFB1I1, XAB2, MYLK, IKBKG, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, ERCC3, RYBP, CTSS, CDKN3, MAP3K7, ALK, NUAK1, CLASP2, CEBPE, DAG1, UBE2I, FOS, PPP2R2A, SMAD1, IGFBP3, DUSP6, EYA1, CSNK1E, ETF1, ASCC2, ORC2L, ERCC4, FGF2, AR, CASP2, ERCC2, CTSF, VCPIP1, HDAC1, RPS6KA1, DACH1, SMAD3, KIFAP3, MAPK8, GNA14, EPHB2, GNAQ, LIN7A, CALR, PSEN1, PTPN21, PLAG1, EGFR, BCR, ZAP70, CASP3, NDN, PIK3R1, MYOG, SI, TBP, HIF1A, CAMK2A, NEDD4, ASCC3, LIMK1, MYOD1, RBL1, CASP6, PAK1, PTPRM, NCOR1, MIZF, RAG2, MLLT1, TRAF6, CDC45L, MAPKAPK2, RELA, SIX3, HAND1, STK11, PLAU, ZNF423, RAD52, PARD3, NCOA2, HSF1, MAFK, MNDA, TUBA3C, GATA4, GZMB, LLGL1, POU2AF1, STAT1, MAP2K7, PPEF1, PRM1, PLAT, PRKCD, POU1F1, SLC9A3R1, PTPN7, OTUD7B, BMX, ADRBK1, FOXH1, EBI3, SRY, POU3F3, CHEK1, SRPK1, USP2, CASP5, PHOX2A, RHO, MCM7, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, PTPN11, PPFIBP2, FOXL2, GJA1, RFXAP, APOBEC1, ZNF208, EPHA2, MBD2, GTF2F2, GADD45G, TNFRSF1B, WRN, IL4, SLC9A3R2, SREBF2, KPNA2, GSK3A, MAPK1, CBX5, HOXC8, WASL, USP9X, CRKL, MPP6, DBP, TCEA2, EPHB1, ZBTB16, TRPC5, CD74, APP, GUCY2C, RAF1, MDFI, CTNND1, MAGI1, BMP1, C1QA, CDC2, PRKAR2A, NSF, PEX6, CASP8, PCSK1, SALL1, CHRM3, HDAC6, PAX5, BICD1, DFFB, SIAH1, FER, NTRK1, SMAD2, MMP1, HCK, TRAF1, PRKAB1, TLN1, SMAD7, HAND2, MDM2, SIX1, FANCA, POU3F2, RAC1, HDAC4, SOX10, WT1, PER1, MEOX1, MEOX2, JAK1, YBX1, PARP1, HDAC5, TEK, MARK4, SFRS2IP, DLG4, AKT2, AXIN1, WNT2, MARK3, TGM2, PTK2, PPARA, NOL3, TTN, IL12A, EIF5A, PARK2, HOXD4, CHAF1B, BRSK2, TCF3, CAMK4, PRKACA, CFTR, ADRB2, CASK, NMI, ASF1A, TJP1, ATG12, TP73, BMI1, FRK, MAPK14, AP2B1, AKT1, REN, CTGF, TUBA4A, ATR, CRYAA, MAPK3, CD28, TNK2, FGFR1, MARK1, ETS1, CREBBP, MSC, ANKRD1, ATOX1, PDE4DIP, MYF5, MBL2, TRIP4, HEYL, SMAD4, NOTCH4, XPA, APC2, MAP3K4, ZBTB33, VHL, PRKAA1, CHAF1A, HOXA9, LRP2, EAF2, LNPEP, MITF, NHLH1, HOXB6, MYT1, FES, SERPINA5, CTNNB1, PRKCA, PFTK1, CD46, PARD6B, STAMBPL1, NFE2, WIPF1, SLC2A4, MYC, BUB1B, PTPRS, TP53, MEIS1, TFDP2, ZMYND11, NCK1, LMTK2, CSF1R, APBB1, PKN1, ASCC1, HIC1, COPS5, VCP, NTRK2, ERC1, 652 7216 15360 1.2699794594153415 1.462541840968612E-7 2.358938600011129E-9 5.3251247855712336E-8 GOTERM_BP_ALL GO:0031175~neurite development 17 0.32% 0.001978337409447673 PRKG1, GJA1, UBB, LIMK1, DLX5, BAI1, NDN, PTPRZ1, PARD6B, CDK5R1, APBB1, POU3F2, PTPN11, CHAT, SIAH1, PARD3, MCF2, 652 167 15360 2.3981484882994746 0.999969703547514 0.038218600545741555 3.7174203872475386 GOTERM_BP_ALL GO:0048666~neuron development 23 0.44% 2.3815888935782516E-5 PRKG1, GJA1, UBB, GNAQ, LIMK1, NLGN1, DLX5, BAI1, NDN, PTPRZ1, PARD6B, CDK5R1, APP, PICK1, APBB1, POU3F2, PTPN11, CDKN1C, CHAT, RND1, SIAH1, PARD3, MCF2, 652 193 15360 2.807463682888839 0.11761796501748512 7.107142008743184E-4 0.04554960130230823 GOTERM_BP_ALL GO:0019538~protein metabolic process 240 4.55% 9.418136020963721E-14 KIT, HSF1, PPP5C, CAPN3, TUBA3C, LLGL1, GZMB, CDC37, CRY1, STAT1, MAP2K7, CDK3, PPEF1, FYN, PRKCG, ATG7, PLAT, PRKCD, ABL2, PRKD3, SLC9A3R1, DUSP22, OTUD7B, PTPN7, BMX, ADRBK1, EBI3, CHEK1, MAP3K14, SRPK1, USP2, CASP5, CLTCL1, MMP13, CYLD, RHO, PTPRG, MAP3K3, ITGB2, MAP3K5, CSNK1A1, CTBP1, GSPT2, CSNK2A1, PTPN11, PPEF2, GJA1, UBB, APOBEC1, TUBB, CTSB, JUN, EPHA2, MBD2, PTPRZ1, PICK1, TSC2, CAV1, IL4, STUB1, TGFBR1, MMP3, SLC9A3R2, FGFR4, CDC25A, BCL10, GSK3A, MAPK1, WASL, USP9X, CRKL, RNF2, PPM1A, MPP6, ANAPC10, HSP90AA1, EPHB1, ZBTB16, TRPC5, CD74, PAK7, GUCY2C, RAF1, EP300, BAG4, MAGI1, BMP1, TRPC4, C1QA, CDC2, WAS, LIPE, MDM4, PRKAR2A, IGF1R, NSF, BMPR1A, PEX6, CASP8, PCSK1, CHRM3, HDAC6, SIAH1, FER, NTRK1, PTPRN, PRKG1, MMP1, HCK, TRAF1, TLN1, MDM2, MAP3K8, FANCA, RAC1, MYLK, SRC, UBE2O, CDC14A, SNX17, JAK1, PLG, TNFRSF14, PARP1, TEK, MARK4, CTSS, CDKN3, MAP3K7, ALK, DLG4, AKT2, AXIN1, NUAK1, WNT2, MARK3, TGM2, CLASP2, PTK2, TTN, CEBPE, IL12A, EIF5A, DAG1, UBE2I, PARK2, CHAF1B, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, DUSP6, CSNK1E, ETF1, CFTR, ADRB2, CASK, TJP1, ATG12, FRK, BMI1, FGF2, MAPK14, CASP2, CTSF, AP2B1, VCPIP1, AKT1, REN, HDAC1, RPS6KA1, TUBA4A, SMAD3, KIFAP3, CRYAA, MAPK8, GNA14, EPHB2, MAPK3, TNK2, CD28, FGFR1, GNAQ, LIN7A, MARK1, CALR, PSEN1, CREBBP, ATOX1, PDE4DIP, PTPN21, MBL2, EGFR, SMAD4, BCR, ZAP70, CASP3, MAP3K4, APC2, PIK3R1, VHL, PRKAA1, CHAF1A, LRP2, LNPEP, CAMK2A, MYT1, NEDD4, SERPINA5, FES, PRKCA, LIMK1, PFTK1, MYOD1, CASP6, CD46, PARD6B, PAK1, STAMBPL1, PTPRM, WIPF1, BUB1B, TRAF6, PTPRS, TP53, MAPKAPK2, RELA, NCK1, LMTK2, STK11, CSF1R, APBB1, PLAU, PKN1, COPS5, PARD3, VCP, NTRK2, ERC1, 652 3691 15360 1.5318308669903413 4.946478782130725E-10 9.892975327829845E-12 1.801003790546929E-10 GOTERM_BP_ALL GO:0012502~induction of programmed cell death 22 0.42% 3.0774064201499453E-4 BAD, TGM2, PRKCA, MAPK1, IKBKG, CASP3, TP53, TUBB, CASP6, IL12A, MAP3K5, DAXX, TNFRSF25, PLG, TRAIP, CD2, ERCC3, TP73, TRAF3, SMAD3, FOXL2, ERCC2, 652 214 15360 2.4218794793876497 0.8015301684266163 0.007257849763468216 0.5870638081191704 GOTERM_BP_ALL GO:0048646~anatomical structure formation 17 0.32% 0.003966824240191928 NOTCH4, SMAD2, FRS2, CTNNB1, FGFR1, CTGF, FGF1, HAND1, CSPG4, HAND2, CASP8, PLG, ATP2B2, FGF2, SMAD3, MAP3K7, S100A7, 652 179 15360 2.237378757240292 0.9999999991477506 0.0685670710501427 7.3216841646314705 GOTERM_BP_ALL GO:0012501~programmed cell death 99 1.88% 1.613424693813695E-22 HSPA5, IKBKG, GZMB, NFKBIA, STAT1, PLG, TNFRSF25, TNFRSF14, ERCC3, HMGB1, MARK4, RYBP, MAP3K7, AXIN1, TGM2, DUSP22, NOL3, DFFA, IL12A, EIF5A, TRAF3, IGFBP3, CASP5, ADRB2, SERPINB2, ITGB2, MAP3K5, ATG12, TP73, FGF2, FOXL2, CASP2, ERCC2, GJA1, AGTR2, TUBB, E2F2, CTSB, ATG5, AKT1, HDAC1, CD2, PAX3, SMAD3, GADD45G, TNFRSF1B, WRN, ACTN1, IL4, MAPK8, CRYAA, CD28, BCL10, NAIP, MAPK1, CALR, PSEN1, CDK5R1, TRAF5, SEPT4, BAD, CASP3, PIK3R1, ZBTB16, VHL, PRKAA1, CD74, APP, TRAIP, EAF2, PAK7, RAF1, EP300, BAG4, BCL2L1, PRKCA, CDC2, KNG1, MDM4, CASP6, IGF1R, PAK1, CASP8, RABEP1, MIF, SFRP1, DFFB, SIAH1, BUB1B, TRAF6, CARD9, TP53, ACTC1, RELA, TRAF1, DAXX, YWHAZ, VCP, ERC1, 652 791 15360 2.948508139886608 8.4769333412971535E-19 3.853151518771433E-20 3.0864570658786224E-19 GOTERM_BP_ALL GO:0002682~regulation of immune system process 12 0.23% 0.003633748439351117 TRAF6, BCL10, IKBKG, C1QA, FYN, MBL2, SMAD3, IL4, MAP3K7, CD46, IL12A, IL27RA, 652 101 15360 2.7990038267630446 0.9999999950628905 0.06382551035886375 6.727014261310638 GOTERM_BP_ALL GO:0010468~regulation of gene expression 160 3.03% 1.4906838464129767E-5 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, POU1F1, PPARA, RFXANK, CEBPE, EIF5A, FOXH1, EBI3, SRY, POU3F3, FOS, CHAF1B, HOXD4, TCF3, SMAD1, EYA1, ETF1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, MCM7, ASCC2, ASF1A, ORC2L, TP73, BMI1, AR, FOXL2, CLIP1, ERCC2, HOXB9, UBB, RELB, E2F2, ATF7IP2, JUN, AKT1, ZNF208, MBD2, HDAC1, HOXB7, PICK1, GTF2F2, PAX3, DACH1, FABP4, SMAD3, IL4, TGFBR1, SREBF2, CD28, BCL10, ETS1, CALR, CREBBP, ANKRD1, MSC, EDA2R, MYF5, SMARCA4, FZD1, PLAG1, RHOH, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, ZBTB16, NDN, FOSL1, TAF13, VHL, PRKAA1, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, PAX5, NCOR1, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, MEIS1, TP53, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, APBB1, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, SOX10, WT1, NCOA2, ERC1, 652 2760 15360 1.3656975193384902 0.07533254392362043 4.633311677185725E-4 0.028512703693839292 GOTERM_BP_ALL GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB cascade 14 0.27% 1.7961320738450244E-4 PPM1A, PPP5C, BCL10, TRAF6, GJA1, TGM2, CARD9, RELA, MAP3K3, CASP8, RHOA, TRAF3IP2, TICAM1, TRAF5, 652 95 15360 3.4717468517920573 0.6108430518850573 0.004484071402250267 0.3430384873220338 GOTERM_BP_ALL GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade 16 0.30% 2.7840319128197133E-5 PPM1A, PPP5C, BCL10, TRAF6, GJA1, TGM2, CARD9, OTUD7B, RELA, MAP3K3, CASP8, RHOA, RHOH, TRAF3IP2, TICAM1, TRAF5, 652 103 15360 3.659538983858479 0.13607997047430054 8.123091918975645E-4 0.05324467128561272 GOTERM_BP_ALL GO:0006816~calcium ion transport 17 0.32% 3.372990096794785E-5 RYR2, CCL8, GJA1, TRPC4, ACCN2, CAV3, TRPC5, CACNA1B, ITPR1, TRPV6, ATP2B2, CACNA1C, FYN, PLN, PKD2, TRPV1, ADRB2, 652 117 15360 3.422998269624036 0.16240441337082123 9.422148180187051E-4 0.06450506577038162 GOTERM_BP_ALL GO:0006809~nitric oxide biosynthetic process 6 0.11% 0.004222563757477312 CAV1, PTX3, HSP90AA1, NOS1, EGFR, AKT1, 652 26 15360 5.436526663520529 0.9999999997788813 0.0725939678284876 7.77583822283352 GOTERM_BP_ALL GO:0051726~regulation of cell cycle 65 1.23% 2.5266600401588582E-14 CD28, CDC25A, BCL10, CDK5R2, RAP1A, FGF8, CDC37, CALR, CDC14A, CDK5R1, STAT1, CDK3, HDAC5, ERCC3, EGFR, CDKN3, AXIN1, ANAPC10, CASP3, APC2, NDN, VHL, RCC1, RB1, CHEK1, SRPK1, DUSP6, NEDD9, ADCYAP1, GTF2H1, CYLD, PRKCA, CDC2, MDM4, FGF7, IGF1R, RBL1, TP73, FRK, FGF2, PTPN11, CDKN1C, ERCC2, MYC, BUB1B, CDC45L, TP53, ZMYND11, TFDP2, E2F2, STARD13, FGF1, STK11, APBB1, TSC2, ATR, MDM2, HIC1, GADD45G, COPS5, PKD2, EPHB2, WT1, MAPK3, PLEKHO1, 652 529 15360 2.894684959467452 1.3299494838747705E-10 2.8296254228621365E-12 4.842792833414933E-11 GOTERM_BP_ALL GO:0006796~phosphate metabolic process 120 2.27% 1.8021116990953618E-24 KIT, PPP5C, SRC, CDC14A, STAT1, JAK1, TNFRSF14, MAP2K7, CDK3, PPEF1, TEK, FYN, MARK4, CDKN3, PRKCG, MAP3K7, PRKCD, ALK, ABL2, AKT2, NUAK1, WNT2, MARK3, PRKD3, DUSP22, PTPN7, PTK2, BMX, TTN, IL12A, ADRBK1, SLC34A1, CHEK1, MAP3K14, SRPK1, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, DUSP6, CSNK1E, CFTR, CASK, MCM7, PTPRG, MAP3K3, ITGB2, MAP3K5, CSNK1A1, CTBP1, CSNK2A1, FRK, FGF2, PTPN11, PPEF2, MAPK14, JUN, AKT1, EPHA2, RPS6KA1, PTPRZ1, PICK1, IL4, MAPK8, TGFBR1, EPHB2, MAPK3, FGFR4, TNK2, CDC25A, FGFR1, BCL10, GSK3A, MAPK1, MARK1, PSEN1, PTPN21, EGFR, CRKL, BCR, PPM1A, ZAP70, MAP3K4, EPHB1, PIK3R1, PRKAA1, PAK7, GUCY2C, CAMK2A, RAF1, FES, PRKCA, LIMK1, PFTK1, CDC2, LIPE, MYOD1, PRKAR2A, IGF1R, BMPR1A, PAK1, PTPRM, FER, NTRK1, PTPRN, BUB1B, PRKG1, PTPRS, SYNJ1, HCK, MAPKAPK2, LMTK2, STK11, CSF1R, PKN1, MAP3K8, NTRK2, ERC1, MYLK, 652 1036 15360 2.728758556979416 9.468294867047031E-21 5.569585215910018E-22 3.447412456560355E-21 GOTERM_BP_ALL GO:0006793~phosphorus metabolic process 120 2.27% 1.8021116990953618E-24 KIT, PPP5C, SRC, CDC14A, STAT1, JAK1, TNFRSF14, MAP2K7, CDK3, PPEF1, TEK, FYN, MARK4, CDKN3, PRKCG, MAP3K7, PRKCD, ALK, ABL2, AKT2, NUAK1, WNT2, MARK3, PRKD3, DUSP22, PTPN7, PTK2, BMX, TTN, IL12A, ADRBK1, SLC34A1, CHEK1, MAP3K14, SRPK1, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, DUSP6, CSNK1E, CFTR, CASK, MCM7, PTPRG, MAP3K3, ITGB2, MAP3K5, CSNK1A1, CTBP1, CSNK2A1, FRK, FGF2, PTPN11, PPEF2, MAPK14, JUN, AKT1, EPHA2, RPS6KA1, PTPRZ1, PICK1, IL4, MAPK8, TGFBR1, EPHB2, MAPK3, FGFR4, TNK2, CDC25A, FGFR1, BCL10, GSK3A, MAPK1, MARK1, PSEN1, PTPN21, EGFR, CRKL, BCR, PPM1A, ZAP70, MAP3K4, EPHB1, PIK3R1, PRKAA1, PAK7, GUCY2C, CAMK2A, RAF1, FES, PRKCA, LIMK1, PFTK1, CDC2, LIPE, MYOD1, PRKAR2A, IGF1R, BMPR1A, PAK1, PTPRM, FER, NTRK1, PTPRN, BUB1B, PRKG1, PTPRS, SYNJ1, HCK, MAPKAPK2, LMTK2, STK11, CSF1R, PKN1, MAP3K8, NTRK2, ERC1, MYLK, 652 1036 15360 2.728758556979416 9.468294867047031E-21 5.569585215910018E-22 3.447412456560355E-21 GOTERM_BP_ALL GO:0043086~negative regulation of catalytic activity 12 0.23% 9.89323160212161E-4 RB1, PRKCA, FABP4, CASP3, CAV1, CAV3, TP53, GADD45G, DUSP22, GNAI2, DUSP6, GNAI3, 652 86 15360 3.2872021686403197 0.9944860651630516 0.020587039928207096 1.8756830127490742 GOTERM_BP_ALL GO:0045944~positive regulation of transcription from RNA polymerase II promoter 27 0.51% 1.4384986379172436E-8 CTNNB1, GTF2H1, ERCC3, NR5A1, FOXL2, ERCC2, SMAD4, SMAD2, POU1F1, TP53, JUN, FOSL1, PPARA, HAND1, HAND2, RB1, FOXH1, APP, MYOG, SMAD3, HIF1A, SMAD1, IL4, SOX10, EP300, NCOA2, ADRB2, 652 171 15360 3.7197287697772032 7.557586321715881E-5 8.997462526139088E-7 2.7518258127745554E-5 GOTERM_BP_ALL GO:0033674~positive regulation of kinase activity 25 0.47% 3.4258839829334613E-9 KIT, IKBKG, GRM1, GAB1, MAP3K5, FGF2, PTPN11, EGFR, MAP3K7IP1, MAP3K7, PLCE1, FRS2, TRAF6, PRKD3, MAP3K4, PRKAA1, DAXX, PICK1, PKN1, C5AR1, GADD45G, GNB2L1, PARD3, MDFI, ADRB2, 652 138 15360 4.267804747932782 1.7999432684989713E-5 2.399945668862813E-7 6.553664178010621E-6 GOTERM_BP_ALL GO:0043085~positive regulation of catalytic activity 35 0.66% 5.289334692199732E-10 KIT, GNAQ, IKBKG, GRM1, PSEN1, GAB1, MAP3K5, STAT1, FGF2, PTPN11, MAP3K7IP1, EGFR, FOXL2, MAP3K7, PLCE1, FRS2, ABL2, TRAF6, MAP3K4, PRKD3, TP53, PRKAA1, DAXX, PICK1, TSC2, PKN1, C5AR1, SMAD3, GADD45G, GNB2L1, PARD3, VCP, MDFI, ADRB2, ADCYAP1, 652 239 15360 3.4499576456092615 2.7790124992321807E-6 4.086788685242482E-8 1.0118416993165624E-6 GOTERM_BP_ALL GO:0033673~negative regulation of kinase activity 9 0.17% 0.0029384187364103415 RB1, PRKCA, FABP4, CASP3, CAV1, CAV3, GADD45G, DUSP22, DUSP6, 652 58 15360 3.6555955151258726 0.9999998071163908 0.053721632711574596 5.473905293265657 GOTERM_BP_ALL GO:0045941~positive regulation of transcription 38 0.72% 4.846296832032792E-8 CTNNB1, BCL10, GTF2H1, GATA4, ASF1A, CREBBP, ERCC3, TP73, NR5A1, FOXL2, SMAD4, ERCC2, NOTCH4, SMAD2, UBB, POU1F1, TP53, JUN, PPARA, FOSL1, RELA, HAND1, HAND2, RB1, FOXH1, APP, MYOG, ZNF423, SMAD3, TGFB1I1, HIF1A, TCF3, SOX10, SMAD1, IL4, EP300, NCOA2, ADRB2, 652 326 15360 2.746057435356995 2.5459202759281485E-4 2.5719607494867347E-6 9.270888552403989E-5 GOTERM_BP_ALL GO:0043069~negative regulation of programmed cell death 32 0.61% 1.5647796091164962E-8 CD28, BCL10, NAIP, HSPA5, BCL2L1, CDC2, SERPINB2, IGF1R, PSEN1, HMGB1, TP73, MIF, SFRP1, CASP2, MAP3K7, TGM2, CASP3, PIK3R1, RELA, NOL3, AKT1, VHL, PRKAA1, HDAC1, CD74, YWHAZ, PAK7, IL4, CRYAA, MAPK8, BAG4, ERC1, 652 233 15360 3.2354722346559943 8.22101416977361E-5 9.672174279273804E-7 2.993399322859247E-5 GOTERM_BP_ALL GO:0048598~embryonic morphogenesis 15 0.28% 9.779557788685885E-4 FRS2, CTNNB1, BCL10, FGFR1, GNAQ, DLX5, ZBTB16, ZEB2, CASP8, MYF5, ATP2B2, SIX1, FOXL2, MAP3K7, GNA12, 652 127 15360 2.7824742766049946 0.9941463726945183 0.02043370016063273 1.8543219289546053 GOTERM_BP_ALL GO:0043068~positive regulation of programmed cell death 28 0.53% 1.2441852060640138E-5 PRKCA, IKBKG, MAPK1, KNG1, CASP6, CDK5R1, MAP3K5, PLG, TNFRSF25, ERCC3, MARK4, TP73, FOXL2, ERCC2, BAD, TGM2, CASP3, TP53, TUBB, ZBTB16, IL12A, DAXX, TRAIP, CD2, TRAF3, SMAD3, IGFBP3, ADRB2, 652 256 15360 2.5766871165644174 0.06327909133147647 3.890308399462361E-4 0.02379839083723745 GOTERM_BP_ALL GO:0051674~localization of cell 45 0.85% 3.090480150176828E-8 TXN, PRKCA, LIMK1, PSEN1, PARD6B, TWIST1, ITGB2, CDK5R1, STAT3, GAB1, PLG, FYN, CCL5, WNT1, EGFR, WASL, MAPK14, SIAH1, CRKL, IL16, LAMA3, MSN, PRKG1, LAMA1, WNT2, UBB, DOCK2, TUBB, NDN, NCK1, CTGF, ARHGDIB, ZEB2, VIM, IL12A, TLN1, CSPG4, SIX1, CCR4, RAC1, PTGS2, ACTN1, F11R, MAPK8, CFTR, 652 421 15360 2.518106174314734 1.6236064765073888E-4 1.8244233870312598E-6 5.912040182964873E-5 GOTERM_BP_ALL GO:0043067~regulation of programmed cell death 71 1.35% 3.931006417627596E-17 CD28, BCL10, NAIP, IKBKG, HSPA5, MAPK1, CALR, PSEN1, CDK5R1, STAT1, PLG, TNFRSF25, ERCC3, HMGB1, MARK4, MAP3K7, TRAF5, SEPT4, BAD, TGM2, CASP3, PIK3R1, ZBTB16, NOL3, VHL, PRKAA1, IL12A, CD74, TRAIP, PAK7, TRAF3, IGFBP3, CASP5, BAG4, ADRB2, PRKCA, BCL2L1, CDC2, KNG1, SERPINB2, IGF1R, CASP6, CASP8, MAP3K5, TP73, FGF2, MIF, SFRP1, FOXL2, CASP2, ERCC2, TRAF6, CARD9, TP53, TUBB, CTSB, AKT1, TRAF1, RELA, HDAC1, DAXX, YWHAZ, CD2, SMAD3, WRN, ACTN1, IL4, CRYAA, MAPK8, VCP, ERC1, 652 544 15360 3.0747022735474556 2.0653507718215388E-13 6.074561093592762E-15 7.519955892717922E-14 GOTERM_BP_ALL GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 39 0.74% 3.4932349756353035E-8 CTNNB1, BCL10, GTF2H1, GATA4, ASF1A, CREBBP, ERCC3, TP73, NR5A1, PRKCG, FOXL2, SMAD4, ERCC2, NOTCH4, SMAD2, UBB, POU1F1, TP53, JUN, PPARA, FOSL1, RELA, HAND1, HAND2, RB1, FOXH1, APP, MYOG, ZNF423, TGFB1I1, SMAD3, HIF1A, TCF3, SOX10, SMAD1, IL4, EP300, NCOA2, ADRB2, 652 336 15360 2.73444347063979 1.8351772756663998E-4 1.9949389775675286E-6 6.682503628230307E-5 GOTERM_BP_ALL GO:0043066~negative regulation of apoptosis 32 0.61% 1.1470709568784382E-8 CD28, BCL10, NAIP, HSPA5, BCL2L1, CDC2, SERPINB2, IGF1R, PSEN1, HMGB1, TP73, MIF, SFRP1, CASP2, MAP3K7, TGM2, CASP3, PIK3R1, RELA, NOL3, AKT1, VHL, PRKAA1, HDAC1, CD74, YWHAZ, PAK7, IL4, CRYAA, MAPK8, BAG4, ERC1, 652 230 15360 3.2776740464123764 6.026529258140734E-5 7.261094786548128E-7 2.1943291905746065E-5 GOTERM_BP_ALL GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 37 0.70% 1.7092844451792484E-7 CTNNB1, MDM4, PER1, RBL1, TWIST1, STAT3, ORC2L, HDAC5, SMARCA4, HMGB1, FZD1, NCOR1, BMI1, RYBP, CDKN1C, SMAD4, RNF2, CBX2, CDC45L, TP53, ZMYND11, ZBTB16, VHL, ZEB2, MBD2, HAND1, SIX3, RB1, DAXX, ATR, MDM2, ZNF423, FABP4, SMAD3, HDAC4, MDFI, NCOA2, 652 328 15360 2.6574891515786323 8.976549906957176E-4 7.877671814870979E-6 3.2698302555589365E-4 GOTERM_BP_ALL GO:0002521~leukocyte differentiation 17 0.32% 1.729988243035761E-5 RAG2, CTNNB1, ZAP70, RELB, PIK3R1, CEBPE, CD74, RB1, CASP8, CD2, HDAC5, RHOH, HDAC4, TCF3, IL4, RAG1, NTRK1, 652 111 15360 3.6080252031172275 0.08688584059695958 5.28316022860631E-4 0.03308922432289085 GOTERM_BP_ALL GO:0008632~apoptotic program 14 0.27% 3.8021306202513446E-5 BAD, CASP3, BCL2L1, TP53, GZMB, AKT1, DFFA, CASP8, STAT1, SMAD3, DFFB, FOXL2, CASP2, VCP, 652 82 15360 4.022145742929822 0.18107906686452102 0.0010564137737716361 0.07270912125023621 GOTERM_BP_ALL GO:0043065~positive regulation of apoptosis 27 0.51% 3.0228782601467723E-5 PRKCA, IKBKG, MAPK1, KNG1, CASP6, CDK5R1, MAP3K5, PLG, TNFRSF25, ERCC3, TP73, FOXL2, ERCC2, BAD, TGM2, CASP3, TP53, TUBB, ZBTB16, IL12A, DAXX, TRAIP, CD2, TRAF3, SMAD3, IGFBP3, ADRB2, 652 254 15360 2.504226848944495 0.14685386247946264 8.722810137095083E-4 0.05781136129193731 GOTERM_BP_ALL GO:0002520~immune system development 26 0.49% 6.062758591270935E-6 KIT, CTNNB1, NFKBIA, ETS1, IL27RA, CASP8, HDAC5, RHOH, RAG1, CRKL, NTRK1, RAG2, NOTCH4, ZAP70, RELB, PIK3R1, ZBTB16, CEBPE, CD74, RB1, CD2, SIX1, HDAC4, IL4, TCF3, LMO2, 652 218 15360 2.809703382675747 0.031351841160233374 2.0417037362063795E-4 0.01159732821320869 GOTERM_BP_ALL GO:0048589~developmental growth 8 0.15% 9.528662878318315E-4 APP, PLG, SETDB1, UBB, SMARCA4, PTGS2, AKT1, ADRB2, 652 38 15360 4.9596383597029385 0.9933207273902511 0.019993972876250377 1.8071592600731101 GOTERM_BP_ALL GO:0031098~stress-activated protein kinase signaling pathway 15 0.28% 1.1243962576258551E-6 CARD9, MAP3K4, SH2D3C, EDA2R, PAK1, GAB1, MAP3K5, DAXX, MAP2K7, PKN1, MAPK8, MAP3K7, CRKL, MAPK8IP3, MDFI, 652 70 15360 5.048203330411919 0.005890165812060699 4.3437154071845896E-5 0.002150931131483791 GOTERM_BP_ALL GO:0048583~regulation of response to stimulus 7 0.13% 0.005600461806288279 TGM2, PRKCA, FABP4, TNFRSF1B, PTGS2, IL12A, ADRB2, 652 39 15360 4.228409627182633 0.9999999999998469 0.08996595111702876 10.186700351697041 GOTERM_BP_ALL GO:0051649~establishment of cellular localization 59 1.12% 5.574021586080913E-4 KPNA2, PEX26, TUBA3C, LIN7A, HAP1, NFKBIA, CDC37, CALR, SNX17, KIF1C, STAT1, RAB6A, STXBP1, KIFC3, ATP7B, NRXN2, EXOC2, CCL8, POU1F1, HSP90AA1, CD74, SNPH, CACNA1B, PARK2, CAMK4, MDFI, CLTCL1, ADRB2, BCL2L1, RPH3A, WAS, NLGN1, SNCAIP, PEX6, TRPV6, PTPN11, CCL5, WIPF1, PCLO, EXOC3, AP2B1, STX1A, TP53, TUBB, TNNT2, AKT1, PEX19, KIF5A, SNAP25, GABARAPL2, YWHAZ, PICK1, APBB1, RHOA, TUBA4A, SMAD3, CRYAA, VCP, ERC1, 652 881 15360 1.5776829174877962 0.9465713118613299 0.01223299569521974 1.0609311991846448 GOTERM_BP_ALL GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 13 0.25% 1.3021328701860998E-4 BCL10, TRAF6, RELB, C1QA, IL27RA, IL12A, CD46, CD74, EBI3, MBL2, IL4, MAP3K7, PRKCD, 652 80 15360 3.8282208588957056 0.4954988481106143 0.0033646969042010477 0.24880224307634036 GOTERM_BP_ALL GO:0010324~membrane invagination 18 0.34% 0.004349834579338615 SYNJ1, VAV1, SH3GL2, SH3GL3, SYP, CEBPE, GATA2, SNX17, LRP1, RABEP1, CUBN, APP, LRP2, TSC2, PTX3, RAC1, ADRB2, CLTCL1, 652 197 15360 2.1525333997695495 0.999999999887028 0.07397927323852616 8.001064848279693 GOTERM_BP_ALL GO:0002449~lymphocyte mediated immunity 12 0.23% 2.673780507508948E-4 TRAF6, BCL10, C1QA, MBL2, TUBB, IL4, MAP3K7, CD46, IL12A, IL27RA, CD74, PRKCD, 652 74 15360 3.8202619797711823 0.7546310098124764 0.00642419403866179 0.5102523322279673 GOTERM_BP_ALL GO:0051641~cellular localization 61 1.16% 3.795991524804628E-4 KPNA2, PEX26, TUBA3C, LIN7A, HAP1, NFKBIA, CDC37, CALR, SNX17, STAT1, KIF1C, RAB6A, STXBP1, KIFC3, EGFR, ATP7B, NRXN2, EXOC2, CCL8, POU1F1, HSP90AA1, CD74, SNPH, CACNA1B, PARK2, CAMK4, MDFI, CLTCL1, ADRB2, BCL2L1, RPH3A, WAS, NLGN1, SNCAIP, PEX6, TRPV6, CCL5, PTPN11, WIPF1, PCLO, EXOC3, AP2B1, STX1A, TP53, TUBB, TNNT2, AKT1, PEX19, KIF5A, SNAP25, GABARAPL2, YWHAZ, PICK1, APBB1, RHOA, CD2, TUBA4A, SMAD3, CRYAA, VCP, ERC1, 652 906 15360 1.5861536586356804 0.8639581312102657 0.008826559979240978 0.7236740825064314 GOTERM_BP_ALL GO:0002443~leukocyte mediated immunity 12 0.23% 5.327743700303475E-4 TRAF6, BCL10, C1QA, MBL2, TUBB, IL4, MAP3K7, CD46, IL12A, IL27RA, CD74, PRKCD, 652 80 15360 3.533742331288344 0.9391864391863186 0.01184395046281772 1.0142820279468001 GOTERM_BP_ALL GO:0043009~chordate embryonic development 17 0.32% 2.7151678148683108E-5 BCL10, SETDB1, ZEB2, MEOX1, HAND2, MEOX2, CASP8, PLCG1, MYF5, SMARCA4, SIX1, SFRP1, MAP3K7IP1, XAB2, EP300, MAP3K7, GNA12, 652 115 15360 3.48252867431315 0.1329484566071235 8.011219285893878E-4 0.051927968041909356 GOTERM_BP_ALL GO:0045893~positive regulation of transcription, DNA-dependent 35 0.66% 6.621199734837275E-9 CTNNB1, BCL10, GTF2H1, GATA4, ASF1A, ERCC3, TP73, NR5A1, FOXL2, SMAD4, ERCC2, NOTCH4, SMAD2, POU1F1, TP53, JUN, PPARA, FOSL1, RELA, HAND1, HAND2, RB1, FOXH1, APP, MYOG, SMAD3, TGFB1I1, HIF1A, TCF3, SOX10, SMAD1, IL4, EP300, NCOA2, ADRB2, 652 263 15360 3.1351326133103172 3.4787178249118256E-5 4.2947871436993523E-7 1.2666254245452535E-5 GOTERM_BP_ALL GO:0045892~negative regulation of transcription, DNA-dependent 28 0.53% 4.334542524055342E-7 CTNNB1, MDM4, RBL1, TWIST1, STAT3, ORC2L, HDAC5, SMARCA4, HMGB1, NCOR1, BMI1, RYBP, CDKN1C, SMAD4, RNF2, CBX2, ZMYND11, ZBTB16, VHL, MBD2, HAND1, RB1, DAXX, MDM2, SMAD3, HDAC4, MDFI, NCOA2, 652 215 15360 3.0680553573976317 0.002274777897923075 1.8515024818976933E-5 8.291881786970379E-4 GOTERM_BP_ALL GO:0002376~immune system process 80 1.52% 1.9631755241873898E-5 CD28, CXCL2, KIT, BCL10, OPRD1, IKBKG, MNDA, VIPR1, NFKBIA, POU2AF1, ETS1, IL27RA, TNFRSF25, TNFRSF14, HDAC5, SH2D1A, PTX3, FYN, MBL2, RHOH, CTSS, RAG1, MAP3K7, CRKL, DEFB1, S100A7, PRKCD, NOTCH4, CCL8, ZAP70, CASP3, DOCK2, ZBTB16, PIK3R1, CCR1, RFXANK, ARHGDIB, IL12A, CEBPE, CD74, RB1, EBI3, IL4R, CCR4, TCF3, LMO2, CTNNB1, CCL7, PRKCA, C1QA, WAS, VAV1, HLA-DRA, CD46, ITGB2, CASP8, CCL13, EBI2, PAX5, CCL5, CCL17, BMI1, MIF, IL16, NTRK1, RAG2, TRAF6, RELB, C1QBP, TUBB, AKT1, RELA, NCK1, GJA8, CD2, C5AR1, SIX1, SMAD3, HDAC4, IL4, 652 1165 15360 1.617736117327997 0.09800495701369649 5.960434198696296E-4 0.03754856861075684 GOTERM_BP_ALL GO:0048534~hemopoietic or lymphoid organ development 25 0.47% 7.06698651301922E-6 KIT, CTNNB1, NFKBIA, ETS1, CASP8, HDAC5, RHOH, RAG1, CRKL, NTRK1, RAG2, NOTCH4, ZAP70, RELB, PIK3R1, ZBTB16, CEBPE, CD74, RB1, CD2, SIX1, HDAC4, IL4, TCF3, LMO2, 652 206 15360 2.8590148311394366 0.03644920988871292 2.3349524101401453E-4 0.013518172423465646 GOTERM_BP_ALL GO:0045860~positive regulation of protein kinase activity 25 0.47% 1.854605438225052E-9 KIT, IKBKG, GRM1, GAB1, MAP3K5, FGF2, PTPN11, EGFR, MAP3K7IP1, MAP3K7, PLCE1, FRS2, TRAF6, PRKD3, MAP3K4, PRKAA1, DAXX, PICK1, PKN1, C5AR1, GADD45G, GNB2L1, PARD3, MDFI, ADRB2, 652 134 15360 4.395201904587492 9.744049670690202E-6 1.3533467335680172E-7 3.5478321835924476E-6 GOTERM_BP_ALL GO:0045859~regulation of protein kinase activity 41 0.78% 1.9188072702458903E-14 CDC25A, KIT, GTF2H1, CDK5R2, PRKCA, IKBKG, CAV3, GRM1, CDC37, CDK5R1, GAB1, MAP3K5, PTPN11, FGF2, MAP3K7IP1, CDKN1C, EGFR, CDKN3, MAP3K7, PLCE1, FRS2, TRAF6, CASP3, MAP3K4, PRKD3, DUSP22, PRKAA1, RB1, DAXX, PICK1, PKN1, CHEK1, C5AR1, FABP4, CAV1, GADD45G, GNB2L1, PARD3, MDFI, DUSP6, ADRB2, 652 230 15360 4.199519871965857 1.009128336448839E-10 2.2425394874403537E-12 3.673727988484643E-11 GOTERM_BP_ALL GO:0048523~negative regulation of cellular process 128 2.43% 3.2538066119893E-25 HSF1, RAP1A, HSPA5, CAV3, NFKBIA, BAI1, PER1, PLG, HDAC5, TAX1BP3, HMGB1, RYBP, CDKN3, MAP3K7, AXIN1, WNT2, TGM2, POU1F1, CLASP2, OTUD7B, NOL3, ARHGDIB, RGS19, ADRBK1, LRP1, CHEK1, SMAD1, IGFBP3, ADRB2, CFTR, CYLD, RGS2, SERPINB2, ORC2L, CTBP1, ERCC4, TP73, FRK, BMI1, FGF2, CASP2, GJA1, JUN, AKT1, MBD2, HDAC1, TSC2, ATR, FABP4, CAV1, SMAD3, ACTN1, IL4, CRYAA, MAPK8, EPHB2, PLEKHO1, CD28, BCL10, NAIP, MAPK1, ETS1, PSEN1, SMARCA4, FZD1, RHOH, EGFR, RND1, PMP22, SMAD4, NOTCH4, CBX2, RNF2, CASP3, PIK3R1, NDN, ZBTB16, VHL, PRKAA1, CD74, RB1, PAK7, PTGS2, BAG4, MDFI, LMO2, ADCYAP1, SERPINA5, CTNNB1, PRKCA, BCL2L1, CDC2, KNG1, MDM4, IGF1R, RBL1, TWIST1, STAT3, HDAC6, NCOR1, MIF, SFRP1, CDKN1C, MYC, BUB1B, CDC45L, TP53, ZMYND11, RGS14, STARD13, RELA, ZEB2, HAND1, SIX3, STK11, DAXX, YWHAZ, APBB1, ZNF423, MDM2, HIC1, TGFB1I1, RAC1, HDAC4, PKD2, WT1, NCOA2, ERC1, 652 1132 15360 2.6638340306531685 1.7095499939391783E-21 1.139699995959452E-22 6.224482894729147E-22 GOTERM_BP_ALL GO:0048522~positive regulation of cellular process 104 1.97% 7.421858170282132E-18 KIT, PPP5C, IKBKG, GATA4, VIPR1, PLG, TNFRSF25, IRS2, ERCC3, PTX3, MARK4, PRKCG, MAP3K7, TICAM1, HTR1A, WNT2, TGM2, POU1F1, PPARA, IL12A, FOXH1, EBI3, TRAF3, SMAD1, TCF3, IGFBP3, TRAF3IP2, CFTR, ADRB2, GTF2H1, VAV1, FGF7, MAP3K3, ASF1A, MAP3K5, TP73, FGF2, BMI1, FOXL2, ERCC2, LAMA1, GJA1, UBB, TUBB, JUN, LIFR, RHOA, CD2, SMAD3, IL4, TGFBR1, CD28, TNK2, BCL10, FGFR1, MAPK1, ETS1, CREBBP, EDA2R, CDK5R1, EGFR, NR5A1, SMAD4, TRAF5, PPM1A, NOTCH4, BAD, CASP3, ZBTB16, FOSL1, VHL, TSHR, PRKAA1, RB1, APP, TRAIP, MYOG, HIF1A, EP300, CTNNB1, PRKCA, KNG1, DLX5, IGF1R, CASP6, BMPR1A, CASP8, CDKN1C, MYC, SMAD2, TRAF6, CARD9, TP53, RELA, NCK1, HAND1, GATA2, HAND2, DAXX, ZNF423, POU3F2, TGFB1I1, SOX10, NCOA2, 652 996 15360 2.4599009535072804 3.8994442826662326E-14 1.2998147608887442E-15 1.41979025605898E-14 GOTERM_BP_ALL GO:0042981~regulation of apoptosis 69 1.31% 3.9622279594140885E-16 CD28, BCL10, NAIP, IKBKG, HSPA5, MAPK1, CALR, PSEN1, CDK5R1, STAT1, PLG, TNFRSF25, ERCC3, HMGB1, MAP3K7, TRAF5, SEPT4, BAD, TGM2, CASP3, PIK3R1, ZBTB16, NOL3, VHL, PRKAA1, IL12A, CD74, TRAIP, PAK7, TRAF3, IGFBP3, CASP5, BAG4, ADRB2, PRKCA, BCL2L1, CDC2, KNG1, SERPINB2, IGF1R, CASP6, CASP8, MAP3K5, TP73, MIF, SFRP1, FOXL2, CASP2, ERCC2, TRAF6, CARD9, TP53, TUBB, CTSB, AKT1, TRAF1, RELA, HDAC1, DAXX, YWHAZ, CD2, SMAD3, WRN, ACTN1, IL4, CRYAA, MAPK8, VCP, ERC1, 652 538 15360 3.0214153761944944 2.333244708552229E-12 5.984102102729594E-14 8.548717289613705E-13 GOTERM_BP_ALL GO:0048519~negative regulation of biological process 132 2.50% 1.4386115532962367E-25 HSF1, RAP1A, HSPA5, CAV3, NFKBIA, BAI1, PER1, PLG, HDAC5, TAX1BP3, HMGB1, RYBP, CDKN3, PRKCG, MAP3K7, AXIN1, WNT2, TGM2, POU1F1, CLASP2, OTUD7B, NOL3, ARHGDIB, RGS19, ADRBK1, LRP1, CHEK1, SMAD1, IGFBP3, ADRB2, CFTR, CYLD, RGS2, SERPINB2, ORC2L, CTBP1, ERCC4, TP73, FRK, BMI1, FGF2, CASP2, GJA1, JUN, AKT1, MBD2, HDAC1, TSC2, ATR, FABP4, CAV1, SMAD3, ACTN1, IL4, CRYAA, MAPK8, EPHB2, PLEKHO1, CD28, BCL10, NAIP, MAPK1, ETS1, PSEN1, IL27RA, SMARCA4, FZD1, RHOH, EGFR, RND1, PMP22, SMAD4, NOTCH4, CBX2, RNF2, CASP3, PIK3R1, NDN, ZBTB16, VHL, PRKAA1, CD74, RB1, PAK7, PTGS2, BAG4, MDFI, LMO2, ADCYAP1, SERPINA5, CTNNB1, PRKCA, BCL2L1, CDC2, KNG1, MDM4, IGF1R, RBL1, TWIST1, STAT3, HDAC6, NCOR1, MIF, SFRP1, CDKN1C, MYC, BUB1B, CDC45L, TP53, ZMYND11, RGS14, STARD13, RELA, ZEB2, HAND1, SIX3, STK11, DAXX, YWHAZ, APBB1, PLAU, ZNF423, MDM2, HIC1, TGFB1I1, RAC1, HDAC4, PLN, PKD2, WT1, NCOA2, ERC1, 652 1181 15360 2.6331018217897904 7.558465101018428E-22 5.398903643584592E-23 2.752042168903676E-22 GOTERM_BP_ALL GO:0048518~positive regulation of biological process 115 2.18% 1.2311159482257676E-19 KIT, PPP5C, IKBKG, GATA4, VIPR1, PLG, TNFRSF25, IRS2, ERCC3, PTX3, FYN, MARK4, PRKCG, MAP3K7, TICAM1, HTR1A, WNT2, TGM2, POU1F1, PPARA, IL12A, FOXH1, EBI3, TRAF3, SMAD1, TCF3, IGFBP3, TRAF3IP2, CFTR, ADRB2, GTF2H1, VAV1, FGF7, MAP3K3, ASF1A, MAP3K5, TP73, FGF2, BMI1, FOXL2, ERCC2, LAMA1, GJA1, UBB, TUBB, JUN, AKT1, LIFR, RHOA, CD2, CAV1, SMAD3, IL4, STUB1, TGFBR1, TNK2, CD28, FGFR1, BCL10, MAPK1, ETS1, IL27RA, CREBBP, EDA2R, CDK5R1, MBL2, EGFR, NR5A1, SMAD4, TRAF5, NOTCH4, PPM1A, BAD, CASP3, HSP90AA1, ZBTB16, FOSL1, VHL, TSHR, PRKAA1, RB1, APP, TRAIP, MYOG, HIF1A, EP300, CTNNB1, PRKCA, LIMK1, C1QA, KNG1, DLX5, IGF1R, CASP6, CD46, BMPR1A, CASP8, CHRM3, CDKN1C, MYC, SMAD2, TRAF6, CARD9, TP53, RELA, NCK1, HAND1, GATA2, HAND2, DAXX, ZNF423, POU3F2, TGFB1I1, SOX10, NCOA2, 652 1106 15360 2.4495501392294123 6.468283191978183E-16 2.395660441473401E-17 2.3551062109602553E-16 GOTERM_BP_ALL GO:0048513~organ development 117 2.22% 1.7225422680633411E-15 KIT, CAPN3, KCNJ8, CAV3, GATA4, NFKBIA, PLG, IRS2, HDAC5, ERCC3, FYN, RAG1, MAP3K7, S100A7, LAMA3, ALK, PLCE1, WNT2, TGM2, POU1F1, PPARA, BMX, TTN, CEBPE, ADRBK1, FOXH1, SMAD1, TCF3, IGFBP3, ADRB2, CFTR, FGF7, CSRP3, TP73, BMI1, FGF2, MAP3K7IP1, AR, FOXL2, ERCC2, FRS2, GJA1, UBB, RELB, AKT1, CTGF, GJA8, FGF1, CD2, PAX3, SGCG, ATP2B2, SMAD3, IL4, FGFR1, GNAQ, MAPK1, DCN, ETS1, PSEN1, EDA2R, CDK5R1, MYF5, SMARCA4, RHOH, EGFR, NR5A1, CRKL, SMAD4, NOTCH4, PPP3R1, ZAP70, CASP3, PIK3R1, ZBTB16, CD74, CSPG4, RB1, APP, LRP2, MYOG, PTGS2, EP300, CD44, LMO2, BMP1, CTNNB1, WAS, DLX5, PITX2, MYOD1, IGF1R, BMPR1A, TWIST1, CASP8, SALL1, PAX5, PKP2, CHAT, NTRK1, RAG2, SMAD2, PRKG1, HCK, ACTC1, ALPL, RELA, HAND1, SIX3, GATA2, HAND2, CUGBP2, SIX1, POU3F2, HDAC4, PLN, PKD2, 652 1282 15360 2.150014834949226 9.332978834208916E-12 2.275957200481571E-13 3.397282455352979E-12 GOTERM_BP_ALL GO:0033238~regulation of amine metabolic process 9 0.17% 0.0023447996057203374 TNK2, PRKCA, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 652 56 15360 3.7861524978089394 0.9999956006036342 0.044332994407035975 4.391488107202834 GOTERM_BP_ALL GO:0008286~insulin receptor signaling pathway 8 0.15% 6.782879550847638E-4 GAB1, IRS2, TSC2, PRKCA, GRB10, PIK3R1, AKT1, IGF1R, 652 36 15360 5.23517382413088 0.9717011490792011 0.014623160258216972 1.2896072445029105 GOTERM_BP_ALL GO:0008285~negative regulation of cell proliferation 29 0.55% 1.4188028384590919E-6 HSF1, BAI1, MDM4, ETS1, PLG, CTBP1, FGF2, FRK, CDKN1C, CDKN3, PMP22, SMAD4, GJA1, WNT2, CASP3, POU1F1, TP53, NDN, ZBTB16, VHL, RB1, CHEK1, MDM2, CAV1, TGFB1I1, HDAC4, PTGS2, SMAD1, CFTR, 652 242 15360 2.8230999340871064 0.007426680305098854 5.3627305898973354E-5 0.0027141134893216012 GOTERM_BP_ALL GO:0008284~positive regulation of cell proliferation 27 0.51% 1.1172128833553339E-5 KIT, CD28, FGFR1, VIPR1, FGF7, IGF1R, BMPR1A, IRS2, MARK4, FGF2, BMI1, EGFR, MYC, TRAF5, LAMA1, HTR1A, TGM2, FOSL1, NCK1, TSHR, LIFR, IL12A, EBI3, POU3F2, IL4, TGFBR1, ADRB2, 652 240 15360 2.6503067484662575 0.0570091436965483 3.5568638184690915E-4 0.021369949373284403 GOTERM_BP_ALL GO:0008283~cell proliferation 89 1.69% 4.3286074950656634E-17 CD28, KIT, CDC25A, HSF1, FGFR1, TXN, FGF8, VIPR1, BAI1, NFKBIA, ETS1, CDK5R1, CDC14A, GFER, IRS2, PLG, TNFRSF14, CDK3, MARK4, EGFR, CDKN3, PMP22, SMAD4, PRKCD, PLCE1, TRAF5, DBP, HTR1A, WNT2, TGM2, CASP3, POU1F1, ZBTB16, DUSP22, NDN, FOSL1, VHL, TSHR, IL12A, CD74, RB1, EBI3, LRP1, LRP2, TRAIP, CHEK1, PTGS2, RAF1, GNAI2, SMAD1, AREG, ADRB2, CFTR, FES, CTNNB1, MCM7, MDM4, FGF7, IGF1R, BMPR1A, GAB1, CTBP1, CHRM3, FRK, BMI1, MIF, FGF2, CDKN1C, AR, MYC, BUB1B, FRS2, LAMA1, GJA1, SETDB1, TP53, ZMYND11, NCK1, LIFR, FGF1, CSF1R, MDM2, CAV1, POU3F2, TGFB1I1, SMAD3, HDAC4, IL4, TGFBR1, 652 796 15360 2.6340290409100713 2.2742503779075E-13 6.497858222592856E-15 8.280560747450226E-14 GOTERM_BP_ALL GO:0019233~sensory perception of pain 5 0.09% 0.004893444492199445 DLG2, GRM1, NDN, TRPV1, ADRB2, 652 17 15360 6.928906531937929 0.9999999999935907 0.08206204540727757 8.95721668249947 GOTERM_BP_ALL GO:0048489~synaptic vesicle transport 8 0.15% 1.643854691875017E-5 SNPH, SNAP25, CTNNB1, SYNJ1, LIN7A, NLGN1, PCLO, SYP, 652 21 15360 8.974583698510079 0.08274414761045434 5.049533768958225E-4 0.03144200636144845 GOTERM_BP_ALL GO:0008219~cell death 101 1.91% 6.530316300059352E-22 IKBKG, HSPA5, GZMB, NFKBIA, STAT1, PLG, TNFRSF25, TNFRSF14, ERCC3, HMGB1, MARK4, RYBP, PRKCG, MAP3K7, AXIN1, TGM2, DUSP22, NOL3, DFFA, IL12A, EIF5A, TRAF3, IGFBP3, CASP5, ADRB2, SERPINB2, ITGB2, MAP3K5, ATG12, TP73, FGF2, FOXL2, CASP2, ERCC2, GJA1, AGTR2, TUBB, E2F2, CTSB, ATG5, AKT1, HDAC1, PAX3, CD2, SMAD3, GADD45G, TNFRSF1B, WRN, ACTN1, IL4, MAPK8, CRYAA, CD28, BCL10, NAIP, MAPK1, CALR, PSEN1, CDK5R1, TRAF5, SEPT4, BAD, CASP3, PIK3R1, ZBTB16, VHL, PRKAA1, CD74, APP, TRAIP, EAF2, PAK7, TBP, RAF1, EP300, BAG4, BCL2L1, PRKCA, CDC2, KNG1, MDM4, CASP6, IGF1R, PAK1, CASP8, RABEP1, MIF, SFRP1, DFFB, SIAH1, BUB1B, TRAF6, CARD9, TP53, ACTC1, RELA, TRAF1, DAXX, YWHAZ, VCP, ERC1, 652 834 15360 2.8529814185461446 3.4310281840511838E-18 1.429595076687993E-19 1.2492396431034127E-18 GOTERM_BP_ALL GO:0030900~forebrain development 10 0.19% 4.624567968771308E-4 FRS2, PRKG1, CTNNB1, LRP2, POU1F1, SMARCA4, TP73, POU3F2, FYN, GATA2, 652 55 15360 4.283324037925265 0.911990455557172 0.01046567228216777 0.8809739722499987 GOTERM_BP_ALL GO:0019226~transmission of nerve impulse 36 0.68% 2.0068485429515493E-6 CTNNB1, DTNA, SLC6A1, GNAQ, MAPK1, LIN7A, PHOX2A, NLGN1, SNCAIP, VIPR1, HAP1, SLC6A4, GRM1, NOS1, PLP1, MPZ, TH, CHAT, PCLO, PMP22, SNCB, NRXN2, DLG4, WNT2, UBB, DLG2, STX1A, KIF5A, SNPH, CACNA1B, GABARAPL2, SNAP25, PARK2, AKAP9, CAMK4, CFTR, 652 348 15360 2.437063676750582 0.010488599791025677 7.373149725553585E-5 0.0038390011065647656 GOTERM_BP_ALL GO:0019222~regulation of metabolic process 183 3.47% 3.8452075805089186E-8 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, HDAC5, ERCC3, PTX3, TFCP2, HMGB1, RYBP, PRKCG, POU1F1, CLASP2, PPARA, RFXANK, IL12A, CEBPE, EIF5A, FOXH1, EBI3, SRY, POU3F3, FOS, CHAF1B, HOXD4, SRPK1, TCF3, SMAD1, IGFBP3, EYA1, GCM1, ETF1, ADRB2, GTF2H1, MAX, PHOX2A, MCM7, ASCC2, ASF1A, ITGB2, ORC2L, TP73, BMI1, FGF2, FOXL2, AR, CLIP1, ERCC2, HOXB9, GJA1, UBB, RELB, ATF7IP2, E2F2, JUN, AKT1, ZNF208, REN, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, ATR, DACH1, FABP4, CAV1, SMAD3, TNFRSF1B, IL4, STUB1, TGFBR1, SREBF2, TNK2, CD28, KPNA2, BCL10, ETS1, CALR, PSEN1, CREBBP, ANKRD1, MSC, EDA2R, MYF5, SMARCA4, FZD1, PLAG1, RHOH, TRIP4, HOXC8, EGFR, WASL, HEYL, NR5A1, SMAD4, NOTCH4, RNF2, CBX2, DBP, TCEA2, HSP90AA1, ZBTB33, ZBTB16, NDN, FOSL1, TAF13, VHL, PRKAA1, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, EP300, MDFI, CTNND1, SERPINA5, CTNNB1, ASCC3, PRKCA, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, PAX5, NCOR1, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, CDC45L, MEIS1, TP53, MAPKAPK2, ZMYND11, TFDP2, RELA, NCK1, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, APBB1, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, SOX10, WT1, NCOA2, ERC1, 652 2975 15360 1.4491313089653037 2.0200680431281537E-4 2.104447894391015E-6 7.355821459720246E-5 GOTERM_BP_ALL GO:0002252~immune effector process 15 0.28% 2.9797686793788187E-4 RAG2, BCL10, TRAF6, C1QA, TUBB, RELA, CD46, IL27RA, IL12A, CD74, PTX3, MBL2, IL4, MAP3K7, PRKCD, 652 113 15360 3.1272056029100384 0.7910799763856385 0.007060044855499825 0.5684881467809433 GOTERM_BP_ALL GO:0019220~regulation of phosphate metabolic process 12 0.23% 4.269633511272504E-4 TNK2, BCL10, PRKCA, FGF2, MCM7, EGFR, JUN, IL4, IGFBP3, IL12A, PSEN1, ITGB2, 652 78 15360 3.624351109013686 0.893939381877698 0.009792720521194842 0.8136208983255511 GOTERM_BP_ALL GO:0002250~adaptive immune response 13 0.25% 1.3021328701860998E-4 BCL10, TRAF6, RELB, C1QA, IL27RA, IL12A, CD46, CD74, EBI3, MBL2, IL4, MAP3K7, PRKCD, 652 80 15360 3.8282208588957056 0.4954988481106143 0.0033646969042010477 0.24880224307634036 GOTERM_BP_ALL GO:0019219~regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 160 3.03% 1.6197981657700135E-6 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, PRKCG, POU1F1, PPARA, RFXANK, CEBPE, FOXH1, SRY, POU3F3, FOS, CHAF1B, HOXD4, SRPK1, TCF3, SMAD1, EYA1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, MCM7, ASCC2, ASF1A, ORC2L, TP73, BMI1, AR, FOXL2, CLIP1, ERCC2, HOXB9, UBB, RELB, ATF7IP2, E2F2, JUN, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, ATR, DACH1, FABP4, SMAD3, TNFRSF1B, IL4, TGFBR1, SREBF2, BCL10, KPNA2, ETS1, CALR, CREBBP, ANKRD1, MSC, EDA2R, MYF5, SMARCA4, FZD1, PLAG1, RHOH, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, ZBTB16, NDN, FOSL1, TAF13, VHL, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, CAMK2A, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, PAX5, NCOR1, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, CDC45L, MEIS1, TP53, MAPKAPK2, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, APBB1, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, SOX10, WT1, NCOA2, ERC1, 652 2658 15360 1.4181057762882745 0.008474315289658474 5.9930784753414734E-5 0.0030986039234126572 GOTERM_BP_ALL GO:0048469~cell maturation 14 0.27% 1.5431008634503873E-6 CTNNB1, FGFR1, GNAQ, ACTC1, NLGN1, PLP1, TTN, REN, GATA2, APP, PICK1, CDKN1C, SOX10, RND1, 652 62 15360 5.319612111616861 0.008074681391225469 5.7498050411219914E-5 0.0029518873492007103 GOTERM_BP_ALL GO:0048468~cell development 146 2.77% 1.029990894258646E-30 IKBKG, HSPA5, GZMB, NFKBIA, BAI1, STAT1, PLG, TNFRSF25, TNFRSF14, ERCC3, HMGB1, MARK4, FYN, RYBP, PRM1, PRKCG, RAG1, MAP3K7, AXIN1, WNT2, TGM2, DUSP22, NOL3, DFFA, TTN, IL12A, EIF5A, TRAF3, BRSK2, IGFBP3, CASP5, GCM1, ADRB2, CFTR, SERPINB2, NLGN1, PLP1, ITGB2, MAP3K5, ATG12, TP73, FGF2, PTPN11, FOXL2, CASP2, MCF2, ERCC2, FRS2, GJA1, AGTR2, UBB, E2F2, TUBB, CTSB, AKT1, ATG5, EPHA2, REN, PTPRZ1, HDAC1, PICK1, PAX3, CD2, ATP2B2, SMAD3, GADD45G, TNFRSF1B, WRN, ACTN1, IL4, CRYAA, MAPK8, CD28, FGFR1, BCL10, NAIP, GNAQ, MAPK1, CALR, PSEN1, CDK5R1, SMARCA4, HOXC8, RND1, TRAF5, PPP3R1, SEPT4, BAD, CASP3, PIK3R1, NDN, ZBTB16, VHL, PRKAA1, CD74, APP, EAF2, TRAIP, PAK7, CCR4, TBP, RAF1, EP300, BAG4, CTNNB1, PRKCA, BCL2L1, LIMK1, CDC2, KNG1, DLX5, MDM4, MYOD1, IGF1R, CASP6, PARD6B, TWIST1, PAK1, CASP8, RABEP1, MIF, SFRP1, DFFB, CHAT, CDKN1C, SIAH1, BUB1B, PRKG1, TRAF6, CARD9, TP53, ACTC1, TRAF1, RELA, ZEB2, GATA2, DAXX, YWHAZ, CUGBP2, APBB1, SIX1, POU3F2, SOX10, PARD3, VCP, ERC1, 652 1245 15360 2.762657993938946 5.411572158434926E-27 6.764465198043658E-28 1.97035702104007E-27 GOTERM_BP_ALL GO:0002237~response to molecule of bacterial origin 4 0.08% 0.005255204628673103 BCL10, MAPK1, NFKBIA, IL12A, 652 9 15360 10.47034764826176 0.9999999999990513 0.08676867970869917 9.58828678206337 GOTERM_BP_ALL GO:0045786~negative regulation of progression through cell cycle 26 0.49% 2.8373216047382345E-6 BCL10, CYLD, RAP1A, RBL1, TP73, EGFR, CDKN1C, CDKN3, MYC, BUB1B, AXIN1, CASP3, TP53, ZMYND11, STARD13, VHL, STK11, RB1, TSC2, APBB1, HIC1, PKD2, EPHB2, WT1, PLEKHO1, ADCYAP1, 652 209 15360 2.930695394369918 0.014796745016149582 1.0004404801156053E-4 0.0054276137674835745 GOTERM_BP_ALL GO:0008152~metabolic process 434 8.22% 1.7351128320170373E-4 KIT, SLC2A2, PPP5C, CAPN3, CDC37, CRY1, IRS2, CDK3, PTX3, TFCP2, HMGB1, PPP1R3A, FYN, RAG1, PRKCG, ATG7, PLCE1, ABL2, PRKD3, CHKA, DUSP22, RFXANK, DFFA, RCC1, SLC34A1, MAP3K14, GCM1, CLTCL1, MMP13, GTF2H1, CYLD, MAX, ITGB2, MAP3K5, CSNK1A1, CTBP1, PPEF2, CLIP1, HOXB9, UBB, RELB, TUBB, E2F2, ATF7IP2, CTSB, JUN, PTPRZ1, NDOR1, HOXB7, PICK1, TSC2, PAX3, ATP2B2, CAV1, STUB1, TGFBR1, MMP3, FGFR4, CDC25A, ASIP, BCL10, IL27RA, EDA2R, SMARCA4, U2AF2, NR5A1, SNCB, CBX2, RNF2, PPM1A, ANAPC10, HSP90AA1, FOSL1, TAF13, RB1, NCF2, PAK7, EP300, BAG4, TRPC4, WAS, LIPE, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, TH, INSIG2, MIF, CDKN1C, CHAT, PTPRN, PRKG1, SETDB1, ZEB2, GATA2, DAXX, CUGBP2, MAP3K8, TGFB1I1, XAB2, MICAL1, MYLK, IKBKG, CAV3, SRC, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, ERCC3, RYBP, CTSS, CDKN3, MAP3K7, ATP7B, ALK, NUAK1, CPNE1, CLASP2, CEBPE, DAG1, UBE2I, FOS, PPP2R2A, SMAD1, IGFBP3, DUSP6, EYA1, CSNK1E, ETF1, ASCC2, PLP1, ORC2L, ERCC4, FGF2, AR, CASP2, ERCC2, CTSF, VCPIP1, HDAC1, RPS6KA1, DACH1, SMAD3, KIFAP3, MAPK8, GNA14, EPHB2, GNAQ, LIN7A, CALR, PSEN1, FZD1, PTPN21, RHOH, PLAG1, EGFR, BCR, ZAP70, CASP3, NDN, PIK3R1, MYOG, SI, TBP, HIF1A, CAMK2A, NEDD4, ASCC3, LIMK1, MYOD1, RBL1, CASP6, PAK1, PTPRM, NCOR1, MIZF, RAG2, MLLT1, TRAF6, CDC45L, MAPKAPK2, RELA, PLA2G2A, SIX3, HAND1, STK11, DDC, PLAU, PLCG1, ZNF423, RAD52, PARD3, NCOA2, HSF1, MAFK, TUBA3C, MNDA, GATA4, LLGL1, GZMB, POU2AF1, PLCD1, STAT1, MAP2K7, PPEF1, PRM1, PLAT, PRKCD, POU1F1, DOCK2, SLC9A3R1, OTUD7B, PTPN7, BMX, ADRBK1, FOXH1, EBI3, SRY, POU3F3, CHEK1, SRPK1, USP2, CASP5, PHOX2A, RHO, MCM7, PTPRG, MAP3K3, HIST3H3, GSPT2, CSNK2A1, PTPN11, GLS2, PPFIBP2, FOXL2, GJA1, RFXAP, APOBEC1, ZNF208, EPHA2, MBD2, CUBN, GTF2F2, GADD45G, TNFRSF1B, WRN, IL4, SLC9A3R2, SREBF2, GPHN, KPNA2, TXN, GSK3A, ABCB4, MAPK1, CBX5, HOXC8, WASL, USP9X, CRKL, MPP6, DBP, TCEA2, EPHB1, ZBTB16, TRPC5, CD74, APP, GUCY2C, RAF1, PTGS2, MDFI, CTNND1, MAGI1, GPR143, BMP1, C1QA, CDC2, PRKAR2A, NSF, PEX6, CASP8, PCSK1, SALL1, CHRM3, HDAC6, PAX5, BICD1, DFFB, SIAH1, FER, NTRK1, SMAD2, MMP1, HCK, TRAF1, PRKAB1, TLN1, SMAD7, HAND2, MDM2, SIX1, FANCA, POU3F2, RAC1, HDAC4, SOX10, WT1, NOS1, PER1, MEOX1, MEOX2, JAK1, YBX1, PARP1, HDAC5, TEK, MARK4, SFRS2IP, DLG4, AKT2, AXIN1, WNT2, MARK3, TGM2, PTK2, PPARA, NOL3, TTN, IL12A, EIF5A, LRP1, PARK2, HOXD4, CHAF1B, BRSK2, TCF3, CAMK4, PRKACA, CFTR, ADRB2, CASK, NMI, SNCAIP, ASF1A, TJP1, ATG12, TP73, BMI1, FRK, GUCA2A, MAPK14, TTR, AP2B1, AKT1, REN, CTGF, IREB2, TUBA4A, ATR, FABP4, CRYAA, MAPK3, CD28, TNK2, FGFR1, MARK1, TG, ETS1, CREBBP, MSC, ANKRD1, ATOX1, PDE4DIP, MYF5, MBL2, TRIP4, HEYL, SMAD4, NOTCH4, XPA, MAP3K4, APC2, ZBTB33, VHL, PRKAA1, CHAF1A, HOXA9, EAF2, LRP2, LNPEP, MITF, NHLH1, HOXB6, MYT1, SERPINA5, FES, CTNNB1, PRKCA, PFTK1, CD46, PARD6B, STAMBPL1, NFE2, SLC2A4, WIPF1, MYC, BUB1B, PTPRS, SYNJ1, MEIS1, TP53, PDE4D, ZMYND11, TFDP2, ALPL, NCK1, GMIP, LMTK2, CSF1R, APBB1, PKN1, ASCC1, HIC1, COPS5, VCP, NTRK2, ERC1, 652 9181 15360 1.113636257327917 0.5981624513965103 0.004352735535092189 0.33140290754597457 GOTERM_BP_ALL GO:0032990~cell part morphogenesis 20 0.38% 0.005467299183564665 PRKG1, GJA1, UBB, LIMK1, DLX5, BAI1, NDN, NCK1, PTPRZ1, PARD6B, CDK5R1, APBB1, RAC3, POU3F2, RAC1, PTPN11, CHAT, SIAH1, PARD3, MCF2, 652 235 15360 2.004960187965018 0.9999999999996906 0.08873007941685407 9.956343626704744 GOTERM_BP_ALL GO:0032989~cellular structure morphogenesis 42 0.80% 3.980394864631015E-5 CTNNB1, FGFR1, LIMK1, DLX5, LLGL1, BAI1, NOV, PARD6B, ITGB2, CDK5R1, TP73, FYN, WNT1, PTPN11, CHAT, SIAH1, AR, GNA12, MCF2, SMAD4, PLCE1, PRKG1, GJA1, UBB, TP53, CLASP2, NDN, NCK1, VHL, CTGF, PTPRZ1, RB1, APBB1, RAC3, ATP2B2, POU3F2, RAC1, SMAD3, BRSK2, IGFBP3, PARD3, NEDD9, 652 499 15360 1.982861428378229 0.18871357197488603 0.0010943437445688486 0.07611688431170549 GOTERM_BP_ALL GO:0008016~regulation of heart contraction 14 0.27% 3.533022414428472E-8 RYR2, PRKCA, ACTC1, TNNT2, CSRP3, ADRBK1, CACNA1B, SCN5A, S100A1, CUGBP2, CACNA1C, PLN, KCNJ12, ADRB2, 652 46 15360 7.169911976527073 1.8560777392229166E-4 1.9959657626689165E-6 6.758616351021374E-5 GOTERM_BP_ALL GO:0008015~blood circulation 26 0.49% 3.7444207108004097E-8 KCNJ8, PRKCA, KNG1, CSRP3, SCN5A, MEOX2, NFE2, KCNJ12, RYR2, AGTR2, WNT2, ACTC1, TNNT2, REN, CACNA1B, ADRBK1, S100A1, CUGBP2, CACNA1C, CAV1, CHGA, PTGS2, PLN, NTS, CFTR, ADRB2, 652 167 15360 3.667756511516844 1.9671251717523486E-4 2.09289001862345E-6 7.163017815559058E-5 GOTERM_BP_ALL GO:0051348~negative regulation of transferase activity 9 0.17% 0.003642966861650906 RB1, PRKCA, FABP4, CASP3, CAV1, CAV3, GADD45G, DUSP22, DUSP6, 652 60 15360 3.5337423312883436 0.9999999952971459 0.06355841776542659 6.743521277857489 GOTERM_BP_ALL GO:0051347~positive regulation of transferase activity 25 0.47% 5.342307306258794E-9 KIT, IKBKG, GRM1, GAB1, MAP3K5, FGF2, PTPN11, EGFR, MAP3K7IP1, MAP3K7, PLCE1, FRS2, TRAF6, PRKD3, MAP3K4, PRKAA1, DAXX, PICK1, PKN1, C5AR1, GADD45G, GNB2L1, PARD3, MDFI, ADRB2, 652 141 15360 4.177000391593786 2.806808851985032E-5 3.508559689446855E-7 1.0219752599738285E-5 GOTERM_BP_ALL GO:0007626~locomotory behavior 30 0.57% 5.085478729516892E-9 CXCL2, OPRD1, CCL7, PRKCA, MAPK1, CCR3, GRM1, ITGB2, CCL13, RALA, CCL5, FGF2, CCL17, CHAT, MAPK14, FER, IL16, DEFB1, CCL8, DOCK2, CCR1, FOSL1, IL8RA, TSHR, CACNA1B, PLAU, C5AR1, CCR4, TRH, IL4, 652 198 15360 3.569436698271054 2.671874823090281E-5 3.3821646405751693E-7 9.728443484124938E-6 GOTERM_BP_ALL GO:0051338~regulation of transferase activity 42 0.80% 1.9598317033849523E-14 CDC25A, KIT, GTF2H1, CDK5R2, PRKCA, IKBKG, CAV3, GRM1, CDC37, RBL1, CDK5R1, GAB1, MAP3K5, PTPN11, FGF2, MAP3K7IP1, CDKN1C, EGFR, CDKN3, MAP3K7, PLCE1, FRS2, TRAF6, CASP3, MAP3K4, PRKD3, DUSP22, PRKAA1, RB1, DAXX, PICK1, PKN1, CHEK1, C5AR1, FABP4, CAV1, GADD45G, GNB2L1, PARD3, MDFI, DUSP6, ADRB2, 652 241 15360 4.105592750044549 1.0324607835343613E-10 2.2444268665822165E-12 3.75921516138078E-11 GOTERM_BP_ALL GO:0002026~regulation of the force of heart contraction 4 0.08% 0.003616690676854533 ADRBK1, PRKCA, PLN, CSRP3, 652 8 15360 11.77914110429448 0.9999999945982251 0.06396189335854363 6.696462385927693 GOTERM_BP_ALL GO:0051329~interphase of mitotic cell cycle 12 0.23% 0.0017296220713426801 RB1, KPNA2, GSPT2, APBB1, MDM2, CHEK1, ANAPC10, MARK4, CDC2, CDKN1C, CDKN3, RCC1, 652 92 15360 3.072819418511603 0.9998878083905879 0.03424770565414259 3.2573722870968713 GOTERM_BP_ALL GO:0007610~behavior 43 0.81% 1.4478377231819753E-10 CXCL2, OPRD1, CCL7, PRKCA, MAPK1, CCR3, GRM1, ITGB2, CCL13, RALA, MPZ, FYN, CCL5, CCL17, FGF2, CHAT, MAPK14, FER, PRKCG, PMP22, IL16, DEFB1, DLG4, HTR1A, CCL8, AGTR2, DOCK2, NPHP1, CCR1, FOSL1, IL8RA, REN, TSHR, MBD2, CACNA1B, APP, PARK2, PLAU, C5AR1, CCR4, TRH, IL4, TRPV1, 652 328 15360 3.088433338321113 7.606934835369117E-7 1.1525663201616965E-8 2.7696910320784696E-7 GOTERM_BP_ALL GO:0051325~interphase 12 0.23% 0.002870323595968929 RB1, KPNA2, GSPT2, APBB1, MDM2, CHEK1, ANAPC10, MARK4, CDC2, CDKN1C, CDKN3, RCC1, 652 98 15360 2.88468761737824 0.9999997238619441 0.05324858099475993 5.350331526372598 GOTERM_BP_ALL GO:0045637~regulation of myeloid cell differentiation 7 0.13% 0.004911081935901474 RB1, CTNNB1, ZBTB16, NFKBIA, IL4, ETS1, LMO2, 652 38 15360 4.3396835647400716 0.9999999999941606 0.08208483602710093 8.9880807630761 GOTERM_BP_ALL GO:0018212~peptidyl-tyrosine modification 12 0.23% 3.18448251808477E-5 TNK2, KIT, JAK1, STAT1, ABL2, TNFRSF14, PRKCA, FYN, EGFR, IL4, IL12A, ITGB2, 652 59 15360 4.791515025475721 0.15406721727701211 9.138738325510376E-4 0.060901087251274966 GOTERM_BP_ALL GO:0042592~homeostatic process 46 0.87% 8.709598112419724E-9 CTNNB1, BCL10, TXN, CCL7, PRKCA, IKBKG, BCL2L1, CAV3, KNG1, CCR3, CALR, CREBBP, SLC9A1, CSRP3, CCL13, ATOX1, PLG, CCL5, SLC2A4, ATP7B, MYC, PLCE1, RYR2, CP, OPRL1, TGM2, CASP3, SLC9A3R1, CCR1, AKT1, IREB2, APP, CUBN, C5AR1, FABP4, CCR4, CACNA1C, CAV1, ATP2B2, HIF1A, PLN, PKD2, SMAD1, TRPV1, EP300, ADRB2, 652 418 15360 2.5925382334810814 4.575918191607187E-5 5.580514161884764E-7 1.6661328383626994E-5 GOTERM_BP_ALL GO:0018193~peptidyl-amino acid modification 16 0.30% 2.3941391362305908E-4 TNK2, KIT, ABL2, TGM2, PRKCA, AKT1, IL12A, CREBBP, ITGB2, STAT1, JAK1, TNFRSF14, FYN, EGFR, IL4, EP300, 652 124 15360 3.039778349495349 0.7157869947004873 0.005888842642242209 0.45700258471332855 GOTERM_BP_ALL GO:0042551~neuron maturation 6 0.11% 2.836741707257156E-4 APP, PICK1, GNAQ, NLGN1, CDKN1C, RND1, 652 15 15360 9.423312883435583 0.7747705301278593 0.0067834428059732055 0.54127120762959 GOTERM_BP_ALL GO:0006521~regulation of amino acid metabolic process 9 0.17% 0.0023447996057203374 TNK2, PRKCA, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 652 56 15360 3.7861524978089394 0.9999956006036342 0.044332994407035975 4.391488107202834 GOTERM_BP_ALL GO:0051251~positive regulation of lymphocyte activation 9 0.17% 0.0026285428529544018 CD28, EBI3, TRAF6, BCL10, ZAP70, IL4, NCK1, MAP3K7, IL12A, 652 57 15360 3.719728769777204 0.9999990129514267 0.049216738331606 4.910328595048064 GOTERM_BP_ALL GO:0001932~regulation of protein amino acid phosphorylation 9 0.17% 0.002085635440641895 TNK2, PRKCA, FGF2, EGFR, JUN, IL4, IGFBP3, IL12A, ITGB2, 652 55 15360 3.854991634132739 0.9999827788390183 0.03981307734298656 3.915248425084039 GOTERM_BP_ALL GO:0051249~regulation of lymphocyte activation 12 0.23% 7.319255135908184E-4 CD28, EBI3, TRAF6, BCL10, ZAP70, CD2, CASP3, IL4, NCK1, MAP3K7, IL12A, IL27RA, 652 83 15360 3.406016704856235 0.9786551472780302 0.015706395597549827 1.3909112938654489 GOTERM_BP_ALL GO:0007519~skeletal muscle development 16 0.30% 9.428273690546247E-7 UBB, ACTC1, MYOD1, TTN, CSRP3, APP, CUGBP2, PLG, MYOG, MYF5, SIX1, CHAT, IGFBP3, FOXL2, EP300, ADRB2, 652 79 15360 4.7712976624990295 0.004941368403786228 3.69666102424393E-5 0.0018035990992926187 GOTERM_BP_ALL GO:0045595~regulation of cell differentiation 19 0.36% 1.403171862487949E-4 NOTCH4, CTNNB1, GNAQ, MAPK1, DLX5, NLGN1, NFKBIA, ZBTB16, VHL, ETS1, TWIST1, CDK5R1, RB1, SIX1, POU3F2, FGF2, IL4, IGFBP3, LMO2, 652 159 15360 2.8151406412779254 0.5215857185029079 0.0035553951131942485 0.2680835042861096 GOTERM_BP_ALL GO:0051246~regulation of protein metabolic process 25 0.47% 0.0029989851489675198 CD28, TNK2, SERPINA5, BCL10, PRKCA, MDM4, ITGB2, HDAC6, EGFR, PRKCG, GJA1, CLASP2, RELA, AKT1, NCK1, REN, IL12A, PRKAA1, EIF5A, EBI3, APBB1, MDM2, IL4, STUB1, ETF1, 652 307 15360 1.918426889950241 0.9999998598205324 0.05423478415067273 5.583688016095733 GOTERM_BP_ALL GO:0007517~muscle development 26 0.49% 1.202407666753419E-7 CAPN3, CAV3, MYOD1, TWIST1, CSRP3, PLG, HDAC5, MYF5, FGF2, CHAT, FOXL2, UBB, ACTC1, TTN, RB1, APP, CUGBP2, MYOG, SGCG, SIX1, SMAD3, HDAC4, PLN, IGFBP3, EP300, ADRB2, 652 177 15360 3.460538629510242 6.315455172263285E-4 5.795809131736718E-6 2.3001851950921193E-4 GOTERM_BP_ALL GO:0051240~positive regulation of multicellular organismal process 13 0.25% 0.0018985507316103105 BCL10, TRAF6, IKBKG, C1QA, IL27RA, IL12A, CD46, CHRM3, CAV1, FYN, MBL2, MAP3K7, ADRB2, 652 107 15360 2.862221202912677 0.9999538893471794 0.03683986036065212 3.570065538033962 GOTERM_BP_ALL GO:0051239~regulation of multicellular organismal process 42 0.80% 1.2975865561891524E-11 CD28, BCL10, PRKCA, IKBKG, C1QA, GRM1, CD46, IL27RA, CSRP3, SCN5A, CHRM3, FYN, MBL2, MIF, CHAT, KCNJ12, MAP3K7, PLCE1, PRKG1, RYR2, TRAF6, ZAP70, UBB, CASP3, ACTC1, TNNT2, NCK1, IL12A, CD74, ADRBK1, CACNA1B, EBI3, S100A1, CUGBP2, PARK2, CD2, CACNA1C, CAV1, SMAD3, PLN, IL4, ADRB2, 652 292 15360 3.388520043701152 6.817507480771923E-8 1.1362513152590736E-9 2.4822588429174175E-8 GOTERM_BP_ALL GO:0018108~peptidyl-tyrosine phosphorylation 12 0.23% 2.267447135224967E-5 TNK2, KIT, JAK1, STAT1, ABL2, TNFRSF14, PRKCA, FYN, EGFR, IL4, IL12A, ITGB2, 652 57 15360 4.9596383597029385 0.11231029035523665 6.805284675603929E-4 0.04336700672695759 GOTERM_BP_ALL GO:0032774~RNA biosynthetic process 149 2.82% 6.188366857797577E-6 HSF1, MAFK, IKBKG, MNDA, GATA4, POU2AF1, PER1, MEOX1, MEOX2, CRY1, STAT1, YBX1, PARP1, HDAC5, ERCC3, TFCP2, HMGB1, RYBP, POU1F1, PPARA, RFXANK, CEBPE, FOXH1, SRY, POU3F3, FOS, CHAF1B, HOXD4, TCF3, SMAD1, EYA1, GCM1, ADRB2, GTF2H1, MAX, PHOX2A, NMI, MCM7, ASCC2, ASF1A, ORC2L, TP73, BMI1, AR, FOXL2, ERCC2, CLIP1, HOXB9, RELB, RFXAP, E2F2, ATF7IP2, JUN, ZNF208, MBD2, HDAC1, HOXB7, GTF2F2, PAX3, DACH1, SMAD3, IL4, SREBF2, BCL10, ETS1, CALR, CREBBP, ANKRD1, MSC, MYF5, SMARCA4, PLAG1, TRIP4, HOXC8, WASL, HEYL, NR5A1, SMAD4, NOTCH4, CBX2, RNF2, DBP, TCEA2, ZBTB33, NDN, ZBTB16, FOSL1, TAF13, VHL, CHAF1A, RB1, HOXA9, APP, EAF2, MYOG, MITF, TBP, HIF1A, NHLH1, HOXB6, MYT1, EP300, MDFI, CTNND1, CTNNB1, ASCC3, DLX5, PITX2, MDM4, MYOD1, RBL1, TWIST1, STAT3, SALL1, HDAC6, NCOR1, PAX5, NFE2, CDKN1C, MYC, MIZF, SMAD2, MLLT1, SETDB1, MEIS1, TP53, ZMYND11, TFDP2, RELA, ZEB2, HAND1, SIX3, GATA2, HAND2, SMAD7, DAXX, MDM2, ZNF423, ASCC1, SIX1, HIC1, POU3F2, TGFB1I1, HDAC4, COPS5, SOX10, WT1, NCOA2, ERC1, 652 2490 15360 1.4097124695099417 0.03199088949854667 2.0707269809250306E-4 0.01183758824586656 GOTERM_BP_ALL GO:0007507~heart development 21 0.40% 4.25747085979948E-7 PPP3R1, CTNNB1, GJA1, GNAQ, CASP3, GATA4, BMPR1A, PSEN1, HAND1, HAND2, CSRP3, CASP8, ADRBK1, FOXH1, HDAC5, PKP2, MAP3K7IP1, PLN, CRKL, EP300, PLCE1, 652 128 15360 3.865030674846626 0.0022343757241689577 1.83348783581172E-5 8.144446007385397E-4 GOTERM_BP_ALL GO:0009987~cellular process 619 11.73% 9.526201783429717E-18 KIT, CXCL2, SYMPK, PPP5C, CAPN3, HSPA5, NFKBIA, HAP1, BAI1, CDC37, CRY1, SNX5, IRS2, TNFRSF25, FHOD1, CDK3, STXBP1, HMGB1, TFCP2, PTX3, FYN, PPP1R3A, RAG1, PRKCG, ATG7, DEFB1, TICAM1, PLCE1, EXOC2, ABL2, PRKD3, DUSP22, RFXANK, DFFA, RCC1, ARRB2, IL4R, SLC34A1, MAP3K14, NTS, GCM1, CLTCL1, MMP13, GTF2H1, CYLD, MAX, RGS2, VAV1, ITGB2, CSNK1A1, MAP3K5, CTBP1, MPZ, FMNL1, TRPV6, PPEF2, CLIP1, HOXB9, CP, UBB, RELB, ATF7IP2, E2F2, IRS4, TUBB, JUN, CTSB, ARRB1, FGF1, PTPRZ1, HOXB7, PICK1, TSC2, PAX3, CD2, ATP2B2, CAV1, CACNA1C, ACTN1, RAB33B, STUB1, TGFBR1, MMP3, FGFR4, CDC25A, ASIP, BCL10, GRB10, IL27RA, INADL, EDA2R, SH2D1A, SMARCA4, U2AF2, NR5A1, PMP22, SNCB, PPM1A, RNF2, CBX2, ANAPC10, HSP90AA1, SH3GL3, FOSL1, TAF13, RB1, NCF2, PAK7, EP300, AREG, BAG4, VIPR2, SLC6A1, TRPC4, KNG1, LIPE, WAS, DLX5, PITX2, MDM4, IGF1R, BMPR1A, TWIST1, STAT3, EFNA2, TH, INSIG2, MIF, PKP2, CHAT, CDKN1C, PTPRN, PRKG1, OPRL1, SETDB1, ACTC1, ZEB2, PSTPIP1, GATA2, SHANK1, DAXX, CUGBP2, ATG16L1, MAP3K8, TGFB1I1, XAB2, F11R, MICAL1, MYLK, PEX26, IKBKG, CAV3, SRC, VIPR1, CABP2, UBE2O, CDC14A, SNX17, PLG, TNFRSF14, ERCC3, WNT1, AKAP8, RYBP, CTSS, CDKN3, MAP3K7, ATP7B, ALK, HTR1A, CCL8, NUAK1, CLASP2, SNX19, CEBPE, GNAI3, SNPH, DAG1, UBE2I, S100A10, FOS, PPP2R2A, SMAD1, IGFBP3, DUSP6, EYA1, CSNK1E, ETF1, HSPG2, ASCC2, PLP1, CSRP3, ORC2L, ERCC4, FGF2, SYNPO, AR, CASP2, MCF2, IL16, ERCC2, ARHGEF9, CTSF, VCPIP1, ATG5, RPS6KA1, GJA8, HDAC1, RHOA, DACH1, SMAD3, SELE, KIFAP3, GNA14, MAPK8, EPHB2, GNAQ, IQGAP2, LIN7A, CALR, PSEN1, PTPN21, FZD1, PLAG1, RHOH, EGFR, TRAF5, BCR, SEPT4, ZAP70, CASP3, PIK3R1, NDN, IL8RA, TSHR, CSPG4, TRAIP, MYOG, TBP, AKAP9, HIF1A, CAMK2A, NEDD4, ASCC3, BCL2L1, LIMK1, RPH3A, CCR3, MYOD1, CASP6, RBL1, PAK1, ITPR1, RABEP1, NCOR1, PTPRM, MIZF, RAG2, TRAF6, MLLT1, SNAP91, CDC45L, MAPKAPK2, NPHP1, RGS14, STARD13, RELA, PLA2G2A, HAND1, SIX3, STK11, DDC, PLAU, PLCG1, ZNF423, DSG2, RAD52, PARD3, NCOA2, HSF1, MAFK, CDK5R2, TUBA3C, FGF8, MNDA, GATA4, LLGL1, GZMB, POU2AF1, PLCD1, STAT1, RALA, GFER, KIF1C, MAP2K7, PPEF1, PRM1, PLAT, S100A7, PRKCD, POU1F1, DOCK2, SLC9A3R1, OTUD7B, PTPN7, BMX, ADRBK1, FOXH1, CACNA1B, EBI3, SRY, POU3F3, CHEK1, SRPK1, GNB2L1, USP2, CASP5, GNAI1, NEDD9, PHOX2A, RHO, SERPINB2, MCM7, NLGN1, SLC6A4, GRM1, PTPRG, MAP3K3, HIST3H3, GAB1, CCL13, GSPT2, CSNK2A1, SOS1, PTPN11, GLS2, PPFIBP2, FOXL2, LAMA1, GJA1, AGTR2, DLG2, RFXAP, APOBEC1, GPR37, ZNF208, EPHA2, MBD2, CUBN, GTF2F2, GADD45G, TNFRSF1B, WRN, MLLT4, IL4, SLC9A3R2, SREBF2, PLEKHO1, DSC1, GPHN, KPNA2, TXN, GSK3A, MAPK1, CDK5R1, RAB6A, CBX5, GRB7, HOXC8, WASL, USP9X, GJA3, CRKL, NRXN2, MPP6, DBP, ACCN2, TCEA2, EPHB1, CCR1, ZBTB16, TRPC5, CD74, SH3BP1, APP, GUCY2C, CCR4, TRH, PTGS2, RAF1, MDFI, LMO2, MAGI1, CTNND1, ADCYAP1, BMP1, GPR143, CCL7, CDC2, C1QA, RASA2, PRKAR2A, NSF, PEX6, CASP8, PCSK1, SALL1, CHRM3, HDAC6, ERC2, BICD1, PAX5, SFRP1, DFFB, FER, SIAH1, NTRK1, SMAD2, MMP1, HCK, CARD9, TRAF1, PEX19, PRKAB1, TLN1, HAND2, SMAD7, IQGAP1, MDM2, FANCA, SIX1, POU3F2, RAC1, HDAC4, PLN, SOX10, WT1, TRPV1, RAP1A, NOS1, SYP, PER1, MEOX1, MEOX2, IGFALS, JAK1, YBX1, PARP1, TAX1BP3, PDC, HDAC5, TEK, MARK4, SFRS2IP, YWHAE, LAMA3, DLG4, MSN, AXIN1, AKT2, WNT2, TGM2, MARK3, JAM2, PPFIA1, PTK2, NOL3, PPARA, ARHGDIB, TTN, RGS19, IL12A, EIF5A, S100A1, LRP1, CHN1, PARK2, CHAF1B, HOXD4, TRAF3, BRSK2, CAMK4, GNAI2, TCF3, TRAF3IP2, MAPK8IP3, PRKACA, SEPT8, ADRB2, CFTR, GFAP, CASK, NMI, SNCAIP, FGF7, NOV, ASF1A, TJP1, ATG12, TP73, CCL17, GUCA2A, FRK, BMI1, MAP3K7IP1, ABLIM3, MAPK14, GNA12, TTR, FRS2, AP2B1, AKT1, TNNT2, LIFR, CTGF, REN, IREB2, GABARAPL2, SNAP25, TUBA4A, SGCG, ATR, RAC3, FABP4, CRYAA, MAPK3, TNK2, CD28, DSG3, FGFR1, NAIP, OPRD1, TG, MARK1, ETS1, CREBBP, ANKRD1, MSC, ATOX1, MYF5, PDE4DIP, KIFC3, MBL2, TRIP4, RND1, HEYL, SMAD4, NOTCH4, PPP3R1, XPA, BAD, MAP3K4, APC2, ZBTB33, VHL, PRKAA1, VIM, CHAF1A, SH2D3C, HOXA9, EAF2, LRP2, LNPEP, MITF, NHLH1, HOXB6, MYT1, SAG, CD44, ARHGEF7, SERPINA5, FES, CTNNB1, DTNA, ANXA13, PRKCA, PFTK1, CD46, PARD6B, SLA, EBI2, STAMBPL1, CCL5, NFE2, WIPF1, PCLO, EXOC3, MYC, BUB1B, RYR2, PTPRS, SYNJ1, STX1A, MEIS1, TP53, PDE4D, ZMYND11, PKD1, SH3GL2, TFDP2, NCK1, KIF5A, DIXDC1, GIT1, GMIP, LMTK2, CSF1R, YWHAZ, APBB1, PKN1, ASCC1, C5AR1, HIC1, COPS5, PKD2, PPFIA2, VCP, NTRK2, ERC1, 652 12970 15360 1.1243312788833126 5.0050664170139733E-14 1.614537553875475E-15 1.8223480103030647E-14 GOTERM_BP_ALL GO:0009968~negative regulation of signal transduction 17 0.32% 1.2146326117694493E-5 AXIN1, PRKCA, CAV3, RGS2, RGS14, NFKBIA, OTUD7B, RGS19, SIX3, ADRBK1, LRP1, TAX1BP3, CAV1, RHOH, IGFBP3, MDFI, ADRB2, 652 108 15360 3.708248125426039 0.061823503405176616 3.843669855415621E-4 0.0232331801674035 GOTERM_BP_ALL GO:0009967~positive regulation of signal transduction 20 0.38% 2.5718683779016396E-5 PPM1A, PPP5C, BCL10, TRAF6, GJA1, TGM2, CARD9, RELA, MAP3K3, IL12A, EDA2R, CASP8, RHOA, CDKN1C, IL4, TRAF3IP2, MAP3K7, TICAM1, ADRB2, TRAF5, 652 153 15360 3.0795140141946353 0.12639565666321828 7.631420048712645E-4 0.04918798497263177 GOTERM_BP_ALL GO:0009966~regulation of signal transduction 55 1.04% 2.968800482185963E-8 PPP5C, BCL10, IQGAP2, CAV3, NFKBIA, EDA2R, TAX1BP3, RHOH, MAP3K7, SMAD4, TICAM1, BCR, TRAF5, PLCE1, PPM1A, AXIN1, TGM2, OTUD7B, IL12A, RGS19, ADRBK1, LRP1, IGFBP3, TRAF3IP2, MAPK8IP3, MDFI, ARHGEF7, ADRB2, PRKCA, VAV1, RGS2, RASA2, GRM1, MAP3K3, CASP8, SOS1, CDKN1C, MCF2, ARHGEF9, TRAF6, GJA1, CARD9, RGS14, RELA, GIT1, REN, ARRB1, SIX3, IQGAP1, RHOA, TSC2, CAV1, SMAD3, RAC1, IL4, 652 573 15360 2.2612661805800918 1.5596861533484496E-4 1.7725072893881588E-6 5.679268947345051E-5 GOTERM_BP_ALL GO:0006470~protein amino acid dephosphorylation 19 0.36% 1.577545093000079E-5 KIT, CDC25A, PPM1A, PPP5C, PTPRS, PTPN7, DUSP22, PTPRG, PTPRZ1, CDC14A, PPEF1, PTPRM, PTPN21, PTPN11, PPP2R2A, PPEF2, CDKN3, DUSP6, PTPRN, 652 135 15360 3.315610088616223 0.07954288937805754 4.8743923911720444E-4 0.030173884122930428 GOTERM_BP_ALL GO:0051179~localization 183 3.47% 2.740632819780248E-6 SLC2A2, PEX26, KCNJ8, TUBA3C, CAV3, NFKBIA, HAP1, CDC37, SYP, SNX17, STAT1, DOC2B, KIF1C, SNX5, PLG, TAX1BP3, PTX3, STXBP1, KCNJ2, ERCC3, FYN, AKAP8, WNT1, ATG7, S100A7, LAMA3, ATP7B, MSN, EXOC2, CCL8, WNT2, POU1F1, CPNE1, DOCK2, CHKA, SNX19, PPARA, ARHGDIB, IL12A, GNAI3, CEBPE, KCNJ15, SNPH, CACNA1B, LRP1, SLC34A1, PARK2, CAMK4, NGB, MAPK8IP3, ADRB2, CFTR, CLTCL1, HSPG2, VAV1, NLGN1, SNCAIP, SLC6A4, ITGB2, GAB1, TRPV6, PTPN11, MAPK14, AR, IL16, TTR, LAMA1, AP2B1, CP, GJA1, UBB, KCNV2, TUBB, AKT1, TNNT2, CTGF, GJA8, KCNJ9, GABARAPL2, SNAP25, CUBN, PICK1, TUBA4A, CD2, TSC2, RHOA, FABP4, CACNA1C, CAV1, ATP2B2, SMAD3, ACTN1, CRYAA, RAB33B, MAPK8, TXN, KPNA2, ABCB4, LIN7A, KCNJ16, CALR, PSEN1, SLC9A1, KCNJ10, CDK5R1, ATOX1, RAB6A, KCNB1, KIFC3, MBL2, EGFR, WASL, KCNJ12, CRKL, GJA3, NRXN2, ACCN2, HSP90AA1, SH3GL3, NDN, PRKAA1, VIM, TRPC5, SLC22A2, CD74, CSPG4, APP, LRP2, CCR4, AKAP9, PTGS2, MDFI, CTNNB1, SLC6A1, TRPC4, PRKCA, BCL2L1, LIMK1, C1QA, KNG1, WAS, RPH3A, NSF, PARD6B, TWIST1, PEX6, SCN5A, STAT3, ITPR1, RABEP1, BICD1, CCL5, SLC2A4, WIPF1, PCLO, SIAH1, KCNN2, EXOC3, PRKG1, RYR2, SNAP91, SYNJ1, STX1A, TP53, NPHP1, SH3GL2, NCK1, PEX19, KIF5A, ZEB2, TLN1, GATA2, YWHAZ, APBB1, ATG16L1, SIX1, RAC1, PLN, PKD2, F11R, TRPV1, VCP, ERC1, 652 3161 15360 1.3638613236861055 0.014296130386627803 9.794965545484313E-5 0.005242658934712097 GOTERM_BP_ALL GO:0006469~negative regulation of protein kinase activity 9 0.17% 0.0029384187364103415 RB1, PRKCA, FABP4, CASP3, CAV1, CAV3, GADD45G, DUSP22, DUSP6, 652 58 15360 3.6555955151258726 0.9999998071163908 0.053721632711574596 5.473905293265657 GOTERM_BP_ALL GO:0006468~protein amino acid phosphorylation 97 1.84% 3.7510529714650033E-25 KIT, SRC, STAT1, JAK1, MAP2K7, TNFRSF14, CDK3, TEK, FYN, MARK4, PRKCG, MAP3K7, PRKCD, ALK, ABL2, AKT2, NUAK1, WNT2, MARK3, PRKD3, PTK2, BMX, TTN, IL12A, ADRBK1, CHEK1, MAP3K14, SRPK1, BRSK2, CAMK4, IGFBP3, PRKACA, CSNK1E, CFTR, CASK, MAP3K3, ITGB2, MAP3K5, CSNK1A1, CTBP1, CSNK2A1, FGF2, FRK, MAPK14, JUN, AKT1, EPHA2, RPS6KA1, PICK1, IL4, MAPK8, TGFBR1, EPHB2, MAPK3, FGFR4, TNK2, FGFR1, GSK3A, MAPK1, MARK1, EGFR, CRKL, BCR, ZAP70, MAP3K4, EPHB1, PIK3R1, PRKAA1, PAK7, GUCY2C, CAMK2A, RAF1, FES, LIMK1, PRKCA, CDC2, PFTK1, LIPE, MYOD1, PRKAR2A, IGF1R, BMPR1A, PAK1, FER, NTRK1, BUB1B, PRKG1, HCK, MAPKAPK2, STK11, LMTK2, CSF1R, PKN1, MAP3K8, MYLK, ERC1, NTRK2, 652 704 15360 3.24595649749024 1.9708032312077126E-21 1.2317520195048204E-22 7.175707668696456E-22 GOTERM_BP_ALL GO:0051174~regulation of phosphorus metabolic process 12 0.23% 4.269633511272504E-4 TNK2, BCL10, PRKCA, FGF2, MCM7, EGFR, JUN, IL4, IGFBP3, IL12A, PSEN1, ITGB2, 652 78 15360 3.624351109013686 0.893939381877698 0.009792720521194842 0.8136208983255511 GOTERM_BP_ALL GO:0009952~anterior/posterior pattern formation 14 0.27% 5.463458131402317E-6 RNF2, SMAD2, FRS2, ZEB2, BMPR1A, MEOX1, FOXH1, MEOX2, MYF5, SFRP1, HOXB6, EP300, CRKL, SMAD4, 652 69 15360 4.779941317684717 0.028297010365971764 1.8883142855308233E-4 0.010450995267152763 GOTERM_BP_ALL GO:0006464~protein modification process 155 2.94% 1.5097548607509002E-18 KIT, PPP5C, SRC, UBE2O, CDC14A, CRY1, JAK1, STAT1, PARP1, TNFRSF14, MAP2K7, CDK3, TEK, PPEF1, MARK4, FYN, CDKN3, PRKCG, MAP3K7, ATG7, PLAT, PRKCD, ALK, AKT2, ABL2, NUAK1, WNT2, TGM2, MARK3, PRKD3, PTK2, DUSP22, OTUD7B, PTPN7, TTN, BMX, IL12A, ADRBK1, UBE2I, PARK2, CHEK1, MAP3K14, SRPK1, PPP2R2A, BRSK2, CAMK4, IGFBP3, PRKACA, USP2, CSNK1E, DUSP6, CFTR, CYLD, CASK, RHO, PTPRG, MAP3K3, ITGB2, CSNK1A1, MAP3K5, CTBP1, CSNK2A1, ATG12, FRK, BMI1, FGF2, PTPN11, PPEF2, MAPK14, UBB, VCPIP1, JUN, AKT1, EPHA2, PTPRZ1, RPS6KA1, HDAC1, PICK1, IL4, STUB1, TGFBR1, GNA14, MAPK8, EPHB2, MAPK3, FGFR4, TNK2, CDC25A, FGFR1, BCL10, GSK3A, GNAQ, MAPK1, MARK1, PSEN1, CREBBP, PTPN21, EGFR, USP9X, CRKL, BCR, PPM1A, RNF2, ZAP70, ANAPC10, MAP3K4, EPHB1, ZBTB16, PIK3R1, VHL, PRKAA1, LRP2, PAK7, GUCY2C, RAF1, CAMK2A, MYT1, EP300, NEDD4, FES, PRKCA, LIMK1, PFTK1, CDC2, LIPE, MYOD1, PRKAR2A, IGF1R, BMPR1A, PAK1, CHRM3, HDAC6, STAMBPL1, PTPRM, FER, SIAH1, NTRK1, PTPRN, BUB1B, PRKG1, TRAF6, PTPRS, HCK, TP53, MAPKAPK2, LMTK2, STK11, CSF1R, PKN1, MDM2, MAP3K8, VCP, NTRK2, ERC1, MYLK, 652 1804 15360 2.024131786214683 7.93225203838523E-15 2.7352593235811136E-16 2.888138241329834E-15