Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_ALL GO:0006461~protein complex assembly 32 4.72% 3.6222679532893385E-6 ACTN2, XPO1, SRC, WAS, NOD2, LLGL1, CREBBP, APC, PEX14, HMGA1, DLG4, PML, TGM2, PPARGC1A, TP53, SLC9A3R1, MIS12, PICALM, PTK2, TRAF1, NCK1, SYK, PICK1, PXN, AP2M1, CAV1, SMAD3, HCFC1, MAPK8IP2, ADRB2, CLTCL1, MAGI1, 657 295 15360 2.5360266233263675 0.018851476029243752 1.3890590127940694E-4 0.006929116350007369 GOTERM_BP_ALL GO:0045449~regulation of transcription 143 21.09% 7.912279500953676E-4 HSF1, ASF1B, NOD2, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, HMGB2, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, CIITA, SATB1, ZBTB17, PPARA, KLF1, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, HCFC1, EYA1, GCM1, ADRB2, TBR1, RFX1, CAND2, IFI16, NRIP1, IKZF2, ORC2L, DNM2, AR, CCNT1, JUN, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, SMAD3, IL4, HOXA10, IKZF1, TCF4, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, MLLT10, LHX3, CALR, CREBBP, REL, EDA2R, NEUROD1, RUNX3, MYF5, FZD1, PPARG, NPM1, PAWR, NR5A1, RXRG, CBX2, TAF1, PML, PPARGC1A, HCLS1, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, PRKCQ, NHLH1, CAMK2A, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, CITED1, TLX1, CITED2, PIAS3, TWIST1, MYF6, STAT3, E2F1, SALL1, PEX14, HOXB2, PAX5, EN1, HABP4, NFE2, MYC, MLLT1, NCOA1, YEATS4, IRF8, MEIS1, TP53, RYR1, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, SMAD7, HAND2, NR5A2, CRX, FOXO1, APBB1, POU3F2, CNOT3, HDAC4, CEBPB, ASCL1, PAX2, SOX10, WT1, IKZF4, NCOA2, 657 2598 15360 1.2868346216443278 0.9843730318436983 0.016367575918996513 1.50279977831127 GOTERM_BP_ALL GO:0001816~cytokine production 16 2.36% 1.9794710554579044E-4 CD28, LCP2, ELA2, CADM1, NOD2, RELA, SYK, IL27RA, IL12A, REL, EBI3, STAT5A, IL18, PRKCQ, CEBPB, IL4, 657 121 15360 3.0914374127325557 0.6465866839609433 0.004826070591722353 0.3779911141003067 GOTERM_BP_ALL GO:0045445~myoblast differentiation 8 1.18% 4.0595308677657667E-4 PLG, ACTA1, MYOZ1, NOTCH1, IGFBP3, TTN, ITGB1BP3, ACTB, 657 33 15360 5.667635256676352 0.881555473549097 0.009272509309464327 0.7737309648186086 GOTERM_BP_ALL GO:0048015~phosphoinositide-mediated signaling 14 2.06% 5.750568499504212E-4 GNA15, GNAQ, TGM2, NPR3, CA8, PICK1, ERBB2, HMGB2, C5AR1, EGFR, NDC80, GNB2L1, GNG13, HOMER1, 657 106 15360 3.0877918497458428 0.9513068904438272 0.012513619246084406 1.094359329860528 GOTERM_BP_ALL GO:0009893~positive regulation of metabolic process 57 8.41% 3.0792792418169426E-13 CD28, POU2F1, FHL2, CREBBP, REL, NEUROD1, PTX3, PPARG, FOXO4, EGFR, HMGA1, PRKCG, NR5A1, PML, PPARGC1A, HSP90AA1, HCLS1, ELA2, PPARA, SYK, IL12A, EBI3, FOXH1, APP, GLI1, PRKCQ, NOTCH1, EP300, ADRB2, CTNNB1, PRKCA, TLX1, CITED2, MYF6, NRIP1, E2F1, NCOA1, YEATS4, TP53, RYR1, JUN, RELA, HIVEP3, NCK1, SOX9, HAND1, TFAP2B, HAND2, CRX, FOXO1, STAT5A, SMAD3, CEBPB, IL4, SOX10, NCOA2, TCF4, 657 445 15360 2.9946128982607356 1.6181052053809708E-9 4.0452641236754516E-11 5.891509502475856E-10 GOTERM_BP_ALL GO:0009892~negative regulation of metabolic process 46 6.78% 3.935992680734382E-8 SPTA1, CTNNB1, PRKCA, POU2F1, FURIN, MYF6, TWIST1, NR0B1, NRIP1, STAT3, ORC2L, E2F1, APC, HMGB1, PEX14, FZD1, PPARG, RYBP, PAWR, PRKCG, CBX2, DNAJC1, PML, IRF8, TP53, ELA2, SET, ZBTB16, JUN, RELA, CDC6, SOX9, HAND1, SIX3, NF2, APBB1, ID2, CAV1, SMAD3, HDAC4, ZNF238, ZEB1, IGFBP3, TCF4, NCOA2, PDZD3, 657 436 15360 2.46659126136316 2.0677567824090026E-4 2.491527730796861E-6 7.529491843349945E-5 GOTERM_BP_ALL GO:0009891~positive regulation of biosynthetic process 12 1.77% 2.230185943949429E-4 CD28, EBI3, STAT5A, PTX3, HSP90AA1, ELA2, PRKCQ, EGFR, IL4, RELA, SYK, REL, 657 72 15360 3.896499238964992 0.6902130185297612 0.0053857687673311005 0.42576980179306334 GOTERM_BP_ALL GO:0009889~regulation of biosynthetic process 24 3.54% 2.6693252052720394E-5 CD28, APLP1, PPARGC1A, HSP90AA1, STAR, FURIN, ELA2, AKT1, RELA, SYK, REL, EBI3, STAT5A, APBB1, UPF1, HSPB1, PTX3, CAV1, PRKCQ, CEBPB, EGFR, IL4, NR5A1, PDZD3, 657 207 15360 2.7106081662365162 0.1308575283007457 8.707276414223752E-4 0.05105143379233734 GOTERM_BP_ALL GO:0007420~brain development 18 2.65% 4.934928197926438E-4 TBR1, PRKG1, CTNNB1, FGFR1, WNT2, APLP1, SIX3, NEUROD1, E2F1, LRP2, GLI1, APAF1, FYN, POU3F2, EN1, EMX2, ASCL1, ALK, 657 160 15360 2.6301369863013697 0.9252384267510104 0.011068975114731261 0.9398330269635435 GOTERM_BP_ALL GO:0009888~tissue development 35 5.16% 3.502241980575654E-6 CTNNB1, PROX1, WAS, FGF7, EDA2R, PLG, MMP14, NGFR, SPP1, ROR2, EGFR, NR5A1, S100A7, TIE1, ACHE, HCK, AKT1, PPARA, RELA, BMX, SOX9, HAND1, CSPG4, FOXH1, GLI1, BTK, POU3F2, SMAD3, TGM1, NOTCH1, PSEN2, KRT17, IKZF1, ADRB2, HTN1, 657 339 15360 2.413760590509287 0.018232550283041937 1.3529093256070546E-4 0.006699523305730981 GOTERM_BP_ALL GO:0009887~organ morphogenesis 48 7.08% 9.84243681211944E-10 CTNNB1, FGFR1, APLP1, PTEN, MAPK1, IGF1, PROX1, TLX1, LHX3, DCN, CEACAM1, ANGPT1, YY1, FHL1, PLG, ERBB2, MMP14, NGFR, MYF5, PAX5, ROR2, FOXO4, CRKL, THBS1, S100A7, CCL2, TIE1, PML, TGM2, FGD1, AKT1, RELA, KLF1, FGF1, SYK, HAND1, HAND2, CSPG4, CRX, NPPB, AES, GLI1, PAX3, IL18, TGM1, NPR1, CEBPB, EP300, 657 415 15360 2.7040765802937776 5.1712029609518595E-6 8.080025193368812E-8 1.8828432923889693E-6 GOTERM_BP_ALL GO:0051093~negative regulation of developmental process 14 2.06% 1.1084231384834227E-4 CTNNB1, MAPK1, ZBTB16, USH2A, ITGB1BP3, TWIST1, IAPP, STAT5A, NGFR, FOXO4, NOTCH1, IL4, RTN4, LMO2, 657 90 15360 3.6367326230339927 0.4414425465194629 0.0029519683311843847 0.21182675409289198 GOTERM_BP_ALL GO:0007417~central nervous system development 35 5.16% 5.968041945403135E-9 TBR1, CTNNB1, FGFR1, APLP1, PTEN, TLX1, NEUROD1, E2F1, APAF1, NGFR, FYN, WNT1, EN1, EMX2, ALK, PRKG1, WNT2, SH3GL2, SHC3, NDN, ZBTB16, DCX, PTPRZ1, SIX3, LRP2, POU3F3, GLI1, PARK2, ACCN1, POU3F2, NHLH1, ASCL1, ZEB1, SNTG2, GCM1, 657 260 15360 3.1471724622409556 3.135560089917444E-5 4.479440781635091E-7 1.14167734710513E-5 GOTERM_BP_ALL GO:0051092~activation of NF-kappaB transcription factor 6 0.88% 0.002480345618033856 PRKCQ, NOD2, CAMK2A, NPM1, RELA, EDA2R, 657 23 15360 6.098868374032161 0.9999978454404829 0.040829719099886086 4.639675422574941 GOTERM_BP_ALL GO:0001775~cell activation 30 4.42% 3.642641930978881E-7 CD28, LCP2, CD5, WAS, CADM1, VAV1, IL27RA, ERBB2, RAG1, NTRK1, RAG2, ZAP70, CASP3, RYR1, F2, PIK3R1, NCK1, SYK, IL12A, LCK, EBI3, SLAMF1, STAT5A, CD2, IL18, SMAD3, PRKCQ, HDAC4, KIR3DL1, IL4, 657 238 15360 2.946932197536549 0.001912014186890909 1.8402180863796858E-5 6.968295977238803E-4 GOTERM_BP_ALL GO:0051091~positive regulation of transcription factor activity 7 1.03% 0.0014634983114827829 PRKCQ, NOD2, CAMK2A, NPM1, RELA, EP300, EDA2R, 657 30 15360 5.455098934550989 0.9995448357451833 0.027593430641476457 2.762817147822494 GOTERM_BP_ALL GO:0051090~regulation of transcription factor activity 9 1.33% 0.0011628662672399793 ID2, PEX14, PRKCQ, NOD2, CAMK2A, NPM1, RELA, EP300, EDA2R, 657 50 15360 4.208219178082191 0.9977866642362773 0.022976245687505892 2.201250986654668 GOTERM_BP_ALL GO:0030239~myofibril assembly 4 0.59% 0.003696174872552823 ACTA1, MYOZ1, TTN, ACTB, 657 8 15360 11.689497716894977 0.9999999964477363 0.05742124909427648 6.838744387954765 GOTERM_BP_ALL GO:0016525~negative regulation of angiogenesis 7 1.03% 9.983934647148943E-5 NPPB, TIE1, PLG, PML, FOXO4, NPR1, THBS1, 657 19 15360 8.613314107185772 0.4081973811305174 0.00267286088536145 0.19081840616322898 GOTERM_BP_ALL GO:0016485~protein processing 14 2.06% 3.245972475193437E-4 TAF1, DYRK1A, WNT2, FURIN, RYR1, JUN, AKT1, TTN, SYK, MMP14, SCG5, PCSK2, EGFR, PSEN2, 657 100 15360 3.2730593607305933 0.8183567695413989 0.007552274009813287 0.6191258999931781 GOTERM_BP_ALL GO:0016481~negative regulation of transcription 29 4.28% 8.963345970255493E-5 CTNNB1, POU2F1, TWIST1, MYF6, NRIP1, NR0B1, STAT3, ORC2L, E2F1, HMGB1, FZD1, PEX14, PPARG, RYBP, PAWR, CBX2, PML, IRF8, ZBTB16, SOX9, SIX3, HAND1, ID2, SMAD3, HDAC4, ZNF238, ZEB1, NCOA2, TCF4, 657 300 15360 2.2599695585996953 0.3755945139528559 0.0024756426574622514 0.17132820480286748 GOTERM_BP_ALL GO:0016477~cell migration 28 4.13% 3.940583911524592E-5 PTEN, PRKCA, CEACAM1, TWIST1, ITGB2, CAP1, PLG, MMP14, NGFR, FYN, WNT1, EGFR, IL16, NFASC, PRKG1, TIE1, WNT2, ELA2, NDN, NCK1, ITGB1, SYK, IL12A, NF2, ITGB3, CCR4, ASCL1, HBEGF, 657 271 15360 2.4155419636388142 0.18701478723205667 0.0011891909609921258 0.0753558534433818 GOTERM_BP_ALL GO:0001756~somitogenesis 6 0.88% 0.0030244878201162186 MEOX2, MYF5, ROR2, SFRP1, EP300, MYF6, 657 24 15360 5.844748858447488 0.9999998774489456 0.0486654219284669 5.629878014172773 GOTERM_BP_ALL GO:0007399~nervous system development 74 10.91% 1.7523421961066636E-10 POU3F1, FGFR1, DYRK1A, GNAQ, PTEN, NEUROD1, MMP14, FYN, WNT1, EMX2, THBS1, DLG4, ALK, WNT2, ACHE, SHC3, EPHB1, NDN, ZBTB16, DCX, PPP1R9A, NF2, APP, LRP2, POU3F3, PARK2, FOS, GLI1, CCR4, NHLH1, ZEB1, EP300, SNTG2, GCM1, TBR1, CTNNB1, APLP1, IGF1, TLX1, NLGN1, PLP1, TWIST1, STAT3, E2F1, ERBB2, APAF1, NGFR, ERC2, PAX5, APBA2, PTPN11, EN1, CHAT, ERBB3, FGF13, NTRK1, NFASC, PRKG1, SH3GL2, TFAP2B, PTPRZ1, SIX3, CXCL1, PICK1, APBB1, PAX3, POU3F2, ACCN1, HDAC4, CEBPB, ASCL1, PAX2, RTN4, EPHB2, 657 780 15360 2.218007259103149 9.206804388872669E-7 1.5873807823751918E-8 3.3522051801071484E-7 GOTERM_BP_ALL GO:0007398~ectoderm development 17 2.51% 0.0012824813101727159 CTNNB1, PROX1, WAS, RELA, PPARA, AKT1, FGF7, SOX9, EDA2R, GLI1, NGFR, POU3F2, TGM1, NOTCH1, PSEN2, KRT17, S100A7, 657 159 15360 2.4996410212228253 0.9988202836862689 0.02475346757441077 2.425053300844704 GOTERM_BP_ALL GO:0046903~secretion 30 4.42% 0.0016431804747672218 NOS1AP, LCP2, AKAP3, CADM1, KNG1, NOD2, NLGN1, SNCAIP, KRT18, NPHS1, PIGR, CCL5, DNAJC1, CCL8, ACHE, STX1A, RYR1, RAB3B, SYK, SLC22A2, ROPN1B, SNPH, NPPB, SNAP25, PICK1, RPH3AL, CA9, PARK2, SCG5, NPR1, 657 377 15360 1.8603975146251952 0.9998231787114403 0.029657155811598446 3.096994230326633 GOTERM_BP_ALL GO:0032502~developmental process 300 44.25% 2.4058884051832186E-46 FGF8, ITCH, NOD2, LLGL1, HAP1, PTPN6, YY1, FHL3, NR0B1, CASP9, STAT1, CAP1, TNFRSF25, KRT18, MMP14, HMGB1, COL1A2, FYN, MYOZ1, POU5F1, RAG1, PRKCG, S100A7, ZBTB17, BMX, SYK, NF2, FOXH1, ADRBK1, POU3F3, ID2, BTK, NTS, WNT4, GCM1, CLTCL1, NEDD9, CD5, NLGN1, USH2A, DVL1, ITGB2, NRIP1, PRKCE, FHL1, PTPN11, ERBB3, LEP, CD38, ADAMTS1, AGTR2, TUBB, JUN, CTSB, F2, ITGB1BP3, SOX9, PTPRZ1, FGF1, DLG1, HOXB7, AES, CXCL1, PICK1, PAX3, CD2, CAV1, ACCN1, TNFRSF1B, IL4, HOXA10, MMP9, SPTA1, POU3F1, MAPK1, PROX1, LMO1, DCN, IL27RA, EDA2R, IGFBP5, RUNX3, ROR2, NR5A1, CRKL, THBS1, SHC3, EPHB1, ZBTB16, PPP1R9A, AKAP2, APP, PAK7, GLI1, CCR4, PRKCQ, HBEGF, CRYAB, EP300, SNTG2, LMO2, ACTN2, HMGA2, EPB42, SIAH2, APLP1, PIM1, CITED1, CDC2, TLX1, WAS, CADM1, KNG1, ACTN3, MYF6, TWIST1, STAT3, SALL1, ERC2, PAX5, HOXB2, APBA2, SFRP1, PKP2, CHAT, SHC1, FGF13, NTRK1, NFASC, GRN, PRKG1, YEATS4, IRF8, HCK, RYR1, TRAF1, HOXD10, HAND2, CRX, FOXO1, CA9, POU3F2, RAC1, HDAC4, NME1, PLN, CEBPB, PAX2, SOX10, F11R, RTN4, NOS3, MAPK8IP2, HTN1, PRKCZ, ASF1B, DYRK1A, CAV3, MEOX2, PLG, HSPB1, SPP1, WNT1, FOXO4, EMX2, RYBP, DLG4, ALK, WNT2, TGM2, NPR3, PPARA, TTN, KLF1, IL12A, ELMO1, ITGB3, LRP1, PARK2, MYBPC1, FOS, HOXD4, TRAF3, NOTCH1, GZMA, KRT17, IGFBP3, EYA1, ADRB2, TBR1, IGF1, TCL1A, FGF7, ANGPT1, PLP1, CASQ2, IFI16, ERBB2, APAF1, DNM2, AR, GSK3B, CASP2, CCL2, CASC5, AKT1, REN, ACTB, TFAP2B, HDAC1, STAT5A, SGCG, CDH5, SMAD3, TGM1, NPR1, PSEN2, MAPK8, EPHB2, S100A4, IKZF1, CD28, FGFR1, GNAQ, PTEN, TAL1, LHX3, CALR, IAPP, NEUROD1, PRL, MYF5, FZD1, PPARG, GPX1, EGFR, NPM1, PAWR, SEPT4, ACHE, PML, ZAP70, PPARGC1A, CASP3, ANKRD2, HCLS1, PIK3R1, NDN, CASP1, DCX, ABL1, ERBB2IP, CSPG4, ERN1, NPPB, HOXA9, INPP5D, LRP2, IL18, NHLH1, ADD2, ZEB1, CD44, FES, CTNNB1, ANXA13, PRKCA, BCL2L1, CITED2, CEACAM1, PAK1, E2F1, APC, NGFR, EN1, NFE2, RAG2, BCL2L10, TIE1, ACTA1, FGD1, MEIS1, TP53, SH3GL2, DAPK1, MAGED1, RELA, NCK1, ITGB1, SIX3, HAND1, CSF1R, NR5A2, LCK, MX1, IGFBP1, APBB1, PLCG1, CDC7, ASCL1, 657 3262 15360 2.1501222042112156 1.264053768083263E-42 1.264053768083263E-42 4.602428174283696E-43 GOTERM_BP_ALL GO:0032501~multicellular organismal process 304 44.84% 1.829209673205859E-35 RPGRIP1, FGF8, NOD2, HAP1, OPN1LW, YY1, FHL3, NR0B1, SLC5A7, MMP14, COL1A2, FYN, MYOZ1, RAG1, S100A7, TPM3, NTSR1, ZBTB17, ADRA2A, ARRB2, BMX, ACCN3, SYK, NF2, EBI3, FOXH1, ADRBK1, POU3F3, ID2, BTK, NTS, WNT4, GCM1, MMP13, CD5, RHO, NLGN1, RPGR, SLC6A4, USH2A, DVL1, ITGB2, NRIP1, FHL1, PTPN11, ERBB3, LEP, ADAMTS1, AGTR2, F2, ITGB1BP3, SOX9, PTPRZ1, FGF1, HOXB7, AES, CXCL1, PICK1, PAX3, CD2, CAV1, ACCN1, IL4, HOXA10, MMP9, POU3F1, RBP4, TRDN, MAPK1, PROX1, LMO1, DCN, IL27RA, REL, EDA2R, GUCY1B3, PDE6G, NPHS1, ROR2, NR5A1, CRKL, GJA3, THBS1, SNCB, DYSF, ELA2, SHC3, EPHB1, ZBTB16, PPP1R9A, APP, GLI1, MMP8, CCR4, PRKCQ, HBEGF, CRYAB, EP300, SNTG2, LMO2, HMGA2, ACTN2, EPB42, SIAH2, LCP2, DLGAP2, APLP1, PIM1, C1QA, TLX1, WAS, CADM1, KNG1, MMP7, ACTN3, MYF6, TWIST1, SCN5A, STAT3, SALL1, ERC2, PAX5, HOXB2, APBA2, SFRP1, PKP2, CHAT, FGF13, NTRK1, NFASC, GRN, PRKG1, DDO, MMP1, OPRL1, IRF8, HCK, RYR1, HOXD10, HAND2, CRX, FOXO1, POU3F2, HDAC4, PLN, APOH, CEBPB, PAX2, SOX10, RTN4, NOS3, GNG13, AKAP5, HTN1, ASF1B, DYRK1A, TRPC3, CAV3, NOS1, SLC8A1, MEOX2, PLG, PDC, SPP1, WNT1, GRK1, FOXO4, EMX2, KCNK3, RYBP, DLG4, ALK, WNT2, TGM2, NPR3, PPARA, TTN, KLF1, BSN, IL12A, ITGB3, SNPH, LRP1, S100A1, PARK2, MYBPC1, FOS, HOXD4, SP4, NOTCH1, CAMK4, KRT17, IGFBP3, EYA1, HOMER1, ADRB2, TBR1, NOS1AP, IGF1, SNCAIP, TCL1A, FGF7, ANGPT1, PLP1, CASQ2, IFI16, ERBB2, APAF1, PNOC, PRTN3, AR, CCL2, AKT1, REN, ACTB, TFAP2B, SNAP25, STAT5A, SGCG, CDH5, SMAD3, TGM1, NPR1, PSEN2, EPHB2, IKZF1, CD28, FGFR1, OPRD1, GNAQ, PTEN, TAL1, LHX3, IAPP, NEUROD1, PRL, BFSP2, MYF5, FZD1, MBL2, GPX1, EGFR, MYL3, ACHE, PML, ZAP70, PPARGC1A, CASP3, ANKRD2, HCLS1, PIK3R1, NDN, DCX, SLC22A2, CSPG4, NPPB, HOXA9, LRP2, IL18, NHLH1, ADD2, ZEB1, SAG, CD44, FES, CTNNB1, PRKCA, CITED2, CEACAM1, SERPIND1, CD46, E2F1, APC, NGFR, EN1, MYH4, NFE2, BEST1, RAG2, TIE1, RYR2, ACTA1, STX1A, FGD1, MEIS1, TP53, CNN1, SH3GL2, KBTBD10, RELA, NCK1, ITGB1, KIF5A, SIX3, HAND1, CSF1R, NR5A2, LCK, APBB1, PLCG1, C5AR1, RAB27A, ASCL1, CR2, 657 3759 15360 1.8907195030253114 9.610667623023582E-32 2.4026669057558956E-32 3.499250471675053E-32 GOTERM_BP_ALL GO:0007389~pattern specification process 18 2.65% 3.957126747341216E-4 CTNNB1, CITED2, YY1, FGF1, MYF6, NEUROD1, FOXH1, MEOX2, APC, GLI1, MYF5, ROR2, EN1, EMX2, SFRP1, ASCL1, EP300, CRKL, 657 157 15360 2.680394380944071 0.8750055396234787 0.009079085941721354 0.7542830830839731 GOTERM_BP_ALL GO:0051049~regulation of transport 15 2.21% 6.500689403635322E-4 PRKCA, CAV3, SLC9A3, RAB3B, RYR1, SYK, PTX3, SMAD3, PTPN11, RAC1, PLN, CRYAB, GSK3B, CBL, ADRB2, 657 121 15360 2.898222574436771 0.9671752618825592 0.013961590748911346 1.2362710389087872 GOTERM_BP_ALL GO:0045321~leukocyte activation 29 4.28% 8.71675138409813E-8 CD28, LCP2, CD5, WAS, CADM1, VAV1, IL27RA, ERBB2, RAG1, NTRK1, RAG2, ZAP70, CASP3, RYR1, PIK3R1, NCK1, SYK, IL12A, LCK, EBI3, SLAMF1, STAT5A, CD2, IL18, SMAD3, PRKCQ, HDAC4, KIR3DL1, IL4, 657 210 15360 3.228527940856708 4.578732818728559E-4 4.978010847200842E-6 1.6675000547028418E-4 GOTERM_BP_ALL GO:0016337~cell-cell adhesion 27 3.98% 2.8319240783395046E-4 DSC1, DSG3, CTNNB1, DSC3, PTEN, CADM1, NLGN1, CEACAM1, ITGB2, MMP14, APAF1, ROR2, CLSTN3, PKP2, EGFR, CD84, ITGB1, SOX9, SYK, DLG1, NF2, ROPN1B, CD2, DSG2, CDH5, CD44, ICAM5, 657 289 15360 2.1841968052329714 0.7741995491366986 0.006680753380508664 0.5403543267790578 GOTERM_BP_ALL GO:0006366~transcription from RNA polymerase II promoter 74 10.91% 1.0769414113649878E-13 POU2F1, POU2AF1, YY1, FHL2, REL, NEUROD1, STAT1, YBX1, RUNX3, HMGB2, MYF5, HMGB1, PPARG, FOXO4, RYBP, PAWR, NR5A1, CBX2, PPARGC1A, PPARA, ABL1, KLF1, FOXH1, APP, FOS, GLI1, ID2, SP4, NOTCH1, ZNF238, ZEB1, HCFC1, EP300, ADRB2, CTNNB1, CITED1, TLX1, CITED2, TWIST1, MYF6, NRIP1, STAT3, ORC2L, E2F1, PAX5, NFE2, MYC, MLLT1, IRF8, CCNT1, COPS2, TP53, JUN, MAGED1, SOX9, TFAP2B, HAND1, HAND2, NR5A2, CRX, FOXO1, STAT5A, PAX3, POU3F2, SMAD3, HDAC4, CEBPB, COPS5, ASCL1, PAX2, IL4, SOX10, NCOA2, TCF4, 657 669 15360 2.586017432138201 5.658118418239155E-10 1.4889756094760287E-11 2.0601298444944405E-10 GOTERM_BP_ALL GO:0006357~regulation of transcription from RNA polymerase II promoter 57 8.41% 4.926930334674191E-12 POU2F1, YY1, FHL2, NEUROD1, HMGB2, HMGB1, MYF5, PPARG, RYBP, PAWR, NR5A1, CBX2, PPARGC1A, PPARA, ABL1, FOXH1, APP, FOS, GLI1, ID2, SP4, NOTCH1, ZEB1, ZNF238, EP300, ADRB2, CTNNB1, CITED1, TLX1, CITED2, TWIST1, MYF6, NRIP1, STAT3, E2F1, ORC2L, NFE2, MYC, IRF8, TP53, JUN, MAGED1, SOX9, HAND1, TFAP2B, HAND2, CRX, FOXO1, STAT5A, POU3F2, SMAD3, HDAC4, ASCL1, IL4, SOX10, NCOA2, TCF4, 657 476 15360 2.7995855876597213 2.5886183085965797E-8 5.507698741524791E-10 9.425171754173789E-9 GOTERM_BP_ALL GO:0030183~B cell differentiation 9 1.33% 7.178012379703285E-5 RAG2, STAT5A, HDAC4, RYR1, PIK3R1, IL4, RAG1, SYK, NTRK1, 657 34 15360 6.1885576148267525 0.31418427267180293 0.002036552091140287 0.1372249812224724 GOTERM_BP_ALL GO:0006355~regulation of transcription, DNA-dependent 133 19.62% 0.0016625451742158534 HSF1, ASF1B, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, HMGB2, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, CIITA, SATB1, ZBTB17, PPARA, KLF1, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, EYA1, GCM1, ADRB2, TBR1, RFX1, CAND2, IFI16, NRIP1, IKZF2, ORC2L, AR, CCNT1, JUN, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, SMAD3, IL4, HOXA10, IKZF1, TCF4, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, MLLT10, LHX3, CALR, CREBBP, REL, NEUROD1, RUNX3, MYF5, PPARG, PAWR, NR5A1, RXRG, CBX2, TAF1, PML, PPARGC1A, HCLS1, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, NHLH1, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, CITED1, TLX1, CITED2, PIAS3, TWIST1, MYF6, STAT3, E2F1, SALL1, PEX14, HOXB2, PAX5, EN1, HABP4, NFE2, MYC, MLLT1, NCOA1, YEATS4, IRF8, MEIS1, TP53, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, SMAD7, HAND2, NR5A2, CRX, FOXO1, POU3F2, CNOT3, HDAC4, CEBPB, ASCL1, SOX10, PAX2, WT1, IKZF4, NCOA2, 657 2432 15360 1.278538812785388 0.9998403108715218 0.029899053530300645 3.132944106702218 GOTERM_BP_ALL GO:0006351~transcription, DNA-dependent 136 20.06% 0.0014325859410010723 HSF1, ASF1B, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, HMGB2, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, CIITA, SATB1, ZBTB17, PPARA, KLF1, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, HCFC1, EYA1, GCM1, ADRB2, TBR1, RFX1, CAND2, IFI16, NRIP1, IKZF2, ORC2L, AR, CCNT1, JUN, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, SMAD3, IL4, HOXA10, IKZF1, TCF4, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, MLLT10, LHX3, CALR, CREBBP, REL, NEUROD1, RUNX3, MYF5, PPARG, PAWR, NR5A1, RXRG, CBX2, TAF1, PML, PPARGC1A, HCLS1, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, NHLH1, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, CITED1, TLX1, CITED2, PIAS3, TWIST1, MYF6, STAT3, E2F1, SALL1, PEX14, HOXB2, PAX5, EN1, HABP4, NFE2, MYC, MLLT1, NCOA1, YEATS4, IRF8, COPS2, MEIS1, TP53, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, SMAD7, HAND2, NR5A2, CRX, FOXO1, POU3F2, CNOT3, HDAC4, CEBPB, COPS5, ASCL1, SOX10, PAX2, WT1, IKZF4, NCOA2, 657 2487 15360 1.27846537153013 0.999464442922933 0.027213346460717713 2.705215600068256 GOTERM_BP_ALL GO:0006350~transcription 145 21.39% 0.0018262948695190388 HSF1, ASF1B, NOD2, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, HMGB2, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, CIITA, SATB1, ZBTB17, PPARA, KLF1, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, HCFC1, EYA1, GCM1, ADRB2, TBR1, RFX1, CAND2, IFI16, NRIP1, IKZF2, ORC2L, DNM2, AR, CCNT1, JUN, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, SMAD3, IL4, HOXA10, IKZF1, TCF4, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, MLLT10, LHX3, CALR, CREBBP, REL, EDA2R, NEUROD1, RUNX3, MYF5, FZD1, PPARG, NPM1, PAWR, NR5A1, RXRG, CBX2, TAF1, PML, PPARGC1A, HCLS1, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, PRKCQ, NHLH1, CAMK2A, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, CITED1, TLX1, CITED2, PIAS3, TWIST1, MYF6, STAT3, E2F1, SALL1, PEX14, HOXB2, PAX5, EN1, HABP4, NFE2, MYC, MLLT1, NCOA1, YEATS4, IRF8, COPS2, MEIS1, TP53, RYR1, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, SMAD7, HAND2, NR5A2, CRX, FOXO1, APBB1, POU3F2, HDAC4, CNOT3, CEBPB, COPS5, ASCL1, PAX2, SOX10, WT1, IKZF4, NCOA2, 657 2695 15360 1.2578680289052109 0.9999325501297697 0.03235582018914762 3.4364346549168867 GOTERM_BP_ALL GO:0016310~phosphorylation 92 13.57% 7.257994255359606E-16 PRKCZ, FGFR1, DYRK1A, MAPK1, EPHA7, SRC, STAT1, DDR2, CDK3, TEK, FYN, ROR2, GRK1, NEK2, EGFR, PRKCG, CRKL, ALK, TAF1, WNT2, ZAP70, AURKC, HCLS1, ROS1, EPHB1, PTK2, PIK3R1, ABL1, TTN, BMX, IL12A, SYK, NF2, ERN1, ADRBK1, PAK7, TNIK, GUCY2C, MOS, BTK, SNF1LK2, PRKCQ, CAMK2A, CAMK4, IGFBP3, PRKACA, KSR1, FES, PIM1, PRKCA, CASK, CDC2, TEC, LIPE, CBLC, ABI1, PRKAR2A, ITGB2, PAK1, FGR, PRKCE, CTBP1, ERBB2, CSNK2A1, AXL, MAPK14, GSK3B, ERBB3, BLK, NTRK1, CCL2, PRKG1, TIE1, MAPK10, CCNT1, HCK, MAPKAPK2, F2, JUN, DAPK1, AKT1, CSF1R, TXK, LCK, PICK1, MAP3K8, CDC7, NPR1, IL4, MAPK8, EPHB2, MYLK, 657 867 15360 2.4808161244621405 4.083178239966401E-12 1.1668443988810395E-13 1.4876988529977098E-12 GOTERM_BP_ALL GO:0030155~regulation of cell adhesion 10 1.47% 0.002317039125204232 STAT5A, MMP14, TGM2, MYF5, PTEN, IL18, KNG1, VAV1, IL12A, NF2, 657 68 15360 3.43808756379264 0.9999949080458632 0.038922120755750744 4.340582671751414 GOTERM_BP_ALL GO:0030154~cell differentiation 186 27.43% 4.680759873118247E-31 PRKCZ, ASF1B, NOD2, PTPN6, CASP9, STAT1, TNFRSF25, PLG, MMP14, KRT18, HSPB1, HMGB1, FYN, WNT1, FOXO4, MYOZ1, EMX2, RYBP, PRKCG, RAG1, S100A7, WNT2, TGM2, TTN, KLF1, IL12A, SYK, ELMO1, NF2, MYBPC1, ID2, BTK, TRAF3, NOTCH1, GZMA, IGFBP3, GCM1, ADRB2, CD5, IGF1, NLGN1, USH2A, ANGPT1, PLP1, IFI16, ITGB2, FHL1, PRKCE, ERBB2, APAF1, PTPN11, DNM2, GSK3B, CASP2, LEP, CCL2, CD38, AGTR2, TUBB, CASC5, JUN, CTSB, F2, AKT1, REN, SOX9, ITGB1BP3, ACTB, PTPRZ1, FGF1, HDAC1, STAT5A, PICK1, CD2, PAX3, SMAD3, TNFRSF1B, TGM1, PSEN2, IL4, MAPK8, S100A4, MMP9, CD28, FGFR1, GNAQ, PTEN, MAPK1, PROX1, TAL1, CALR, IAPP, EDA2R, NEUROD1, PRL, RUNX3, MYF5, FZD1, PPARG, ROR2, GPX1, NPM1, PAWR, NR5A1, SEPT4, ACHE, PML, ZAP70, PPARGC1A, CASP3, HCLS1, ZBTB16, PIK3R1, NDN, CASP1, DCX, ABL1, PPP1R9A, CSPG4, ERN1, APP, INPP5D, GLI1, PAK7, CCR4, IL18, NHLH1, CRYAB, EP300, LMO2, ACTN2, EPB42, CTNNB1, SIAH2, APLP1, PIM1, ANXA13, PRKCA, CITED1, BCL2L1, CDC2, TLX1, CADM1, KNG1, ACTN3, MYF6, TWIST1, PAK1, E2F1, SALL1, NGFR, PAX5, EN1, SFRP1, CHAT, NTRK1, NFASC, RAG2, BCL2L10, PRKG1, ACTA1, IRF8, TP53, RYR1, DAPK1, MAGED1, TRAF1, RELA, HAND1, HAND2, CRX, LCK, FOXO1, MX1, APBB1, POU3F2, CDC7, HDAC4, NME1, CEBPB, ASCL1, PAX2, SOX10, F11R, RTN4, MAPK8IP2, 657 1835 15360 2.369751035795603 2.459271237336327E-27 3.074089046670409E-28 8.954222926834139E-28 GOTERM_BP_ALL GO:0016265~death 97 14.31% 1.4506338951791332E-19 PRKCZ, NOD2, PTPN6, CASP9, STAT1, PLG, TNFRSF25, KRT18, HSPB1, HMGB1, RYBP, PRKCG, TGM2, IL12A, ELMO1, BTK, TRAF3, IGFBP3, GZMA, ADRB2, CD5, IFI16, ITGB2, PRKCE, APAF1, DNM2, GSK3B, CASP2, CD38, CCL2, AGTR2, TUBB, F2, CTSB, AKT1, SOX9, HDAC1, STAT5A, PAX3, CD2, SMAD3, TNFRSF1B, IL4, PSEN2, MAPK8, MMP9, CD28, MAPK1, PTEN, CALR, IAPP, RUNX3, GPX1, NPM1, PAWR, SEPT4, PML, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, ERN1, INPP5D, APP, PAK7, IL18, CRYAB, EP300, ACTN2, SIAH2, PIM1, APLP1, BCL2L1, PRKCA, CDC2, KNG1, CADM1, ACTN3, PAK1, E2F1, NGFR, SFRP1, BCL2L10, TP53, RYR1, DAPK1, RELA, TRAF1, MAGED1, LCK, FOXO1, MX1, NME1, CEBPB, RTN4, MAPK8IP2, 657 834 15360 2.7191397566878 7.621630485271166E-16 2.822826105655987E-17 2.775040727308757E-16 GOTERM_BP_ALL GO:0042330~taxis 22 3.24% 1.4345787991602316E-6 CCL2, CXCL2, CXCL3, CCL8, CCL7, PRKCA, MAPK1, ELA2, CCR3, CCR1, SERPIND1, IL8RA, SYK, ITGB2, CXCL1, CNTNAP1, C5AR1, CCR4, CCL5, IL4, MAPK14, IL16, 657 149 15360 3.4519322117005298 0.00750894833629312 6.127684133827582E-5 0.00274429188333869 GOTERM_BP_ALL GO:0042325~regulation of phosphorylation 11 1.62% 0.0011470149571511852 PRKCE, PRKCA, HCLS1, EGFR, JUN, IL4, IGFBP3, IL12A, SYK, NF2, ITGB2, 657 74 15360 3.4752560779958035 0.997594206338302 0.02283814071868373 2.1715563647286995 GOTERM_BP_ALL GO:0009790~embryonic development 25 3.69% 0.0023224561892445598 FGFR1, CTNNB1, GNAQ, FGF8, MYF6, EDA2R, MEOX2, APAF1, MYF5, ROR2, SFRP1, EN1, GRN, ZBTB16, HAND1, HAND2, FOXH1, NR5A2, PICK1, GLI1, PLCG1, SMAD3, CEBPB, ZEB1, EP300, 657 299 15360 1.9547655044974876 0.9999950512538432 0.03888725795141057 4.3505181622157 GOTERM_BP_ALL GO:0030099~myeloid cell differentiation 14 2.06% 1.1084231384834227E-4 EPB42, CTNNB1, IRF8, TAL1, HCLS1, ZBTB16, KLF1, IFI16, STAT5A, ID2, IL4, MMP9, LEP, LMO2, 657 90 15360 3.6367326230339927 0.4414425465194629 0.0029519683311843847 0.21182675409289198 GOTERM_BP_ALL GO:0030098~lymphocyte differentiation 13 1.92% 1.3989305294518115E-4 RAG2, ZAP70, RYR1, PIK3R1, SYK, LCK, STAT5A, CD2, ERBB2, HDAC4, IL4, RAG1, NTRK1, 657 80 15360 3.7990867579908674 0.5205182834056932 0.0035446666269812743 0.26727420213694675 GOTERM_BP_ALL GO:0030097~hemopoiesis 27 3.98% 1.8436458190156865E-7 EPB42, CTNNB1, TAL1, IFI16, PRL, ERBB2, RAG1, LEP, NTRK1, RAG2, ZAP70, IRF8, HCLS1, RYR1, PIK3R1, ZBTB16, KLF1, SYK, LCK, STAT5A, CD2, ID2, HDAC4, ADD2, IL4, MMP9, LMO2, 657 192 15360 3.287671232876712 9.68182611253976E-4 9.884151179750944E-6 3.526860706926094E-4 GOTERM_BP_ALL GO:0042312~regulation of vasodilation 4 0.59% 0.002385526023639998 NPPB, CAV1, NPR1, ADRB2, 657 7 15360 13.359425962165687 0.9999964498727326 0.03967078373009081 4.4661232106564475 GOTERM_BP_ALL GO:0042311~vasodilation 7 1.03% 1.375034907594704E-4 NPPB, WNT2, AGTR2, CAV1, KNG1, NPR1, ADRB2, 657 20 15360 8.182648401826484 0.5144597129920171 0.0035011044329693597 0.262714486761928 GOTERM_BP_ALL GO:0016192~vesicle-mediated transport 41 6.05% 1.5261751492693157E-4 CTNNB1, APLP1, AKAP3, WAS, VAV1, NLGN1, CAP1, KRT18, PTX3, CCL5, HGS, DNM2, STX12, EHD2, CCL8, SNAP91, STX1A, SYNJ1, SLC9A3, ELA2, SH3GL2, PICALM, RYR1, RAB3B, SYK, ELMO1, ROPN1B, SNPH, SNAP25, APP, LRP1, LRP2, PICK1, RPH3AL, AP2M1, RAC1, MAPK8IP1, RAB27A, CBL, CLTCL1, ADRB2, 657 509 15360 1.8831803787532184 0.5515300577009332 0.0038479315974282446 0.29155144239871866 GOTERM_BP_ALL GO:0001568~blood vessel development 25 3.69% 1.6046581446023307E-6 FGFR1, CTNNB1, PTEN, ANGPT1, CEACAM1, PLG, MMP14, ERBB2, FOXO4, CRKL, THBS1, S100A7, TIE1, PML, TGM2, AKT1, HAND1, FGF1, CSPG4, HAND2, NPPB, FOXO1, CDH5, IL18, NPR1, 657 188 15360 3.1089089672593024 0.008395440448982994 6.690951269661127E-5 0.0030696421380538297 GOTERM_BP_ALL GO:0050953~sensory perception of light stimulus 19 2.80% 0.004587748431881774 RBP4, RPGRIP1, TRPC3, RHO, RPGR, USH2A, OPN1LW, SIX3, CRX, PDE6G, PDC, BFSP2, EN1, GRK1, PAX2, BEST1, CRYAB, SAG, GJA3, 657 213 15360 2.085450296910841 0.9999999999678141 0.06801246185516052 8.420695151499347 GOTERM_BP_ALL GO:0045165~cell fate commitment 13 1.92% 3.886222258830418E-4 CTNNB1, PROX1, TLX1, TAL1, SOX9, FGF1, NEUROD1, SALL1, WNT1, NOTCH1, PSEN2, ASCL1, GCM1, 657 89 15360 3.414909445385049 0.8702593765923047 0.008956207266805793 0.7408152769142307 GOTERM_BP_ALL GO:0030036~actin cytoskeleton organization and biogenesis 27 3.98% 1.1782682561456937E-6 SPTA1, WAS, LLGL1, CALR, FHL3, CAP1, FMNL1, FHOD1, MYOZ1, EHD2, PRKG1, ACTA1, EPB41L3, FGD1, CNN1, ADRA2A, NCK1, PPP1R9A, ABL1, TTN, DLG1, ACTB, NF2, ELMO1, CXCL1, RAC1, NEDD9, 657 211 15360 2.991625008115302 0.006171502626058589 5.158721154330248E-5 0.0022539852997272014 GOTERM_BP_ALL GO:0030029~actin filament-based process 29 4.28% 4.1049249421226186E-7 SPTA1, WAS, LLGL1, CALR, FHL3, CAP1, FMNL1, FHOD1, MYOZ1, MYH4, EHD2, PRKG1, ACTA1, EPB41L3, FGD1, CNN1, ADRA2A, NCK1, PPP1R9A, ABL1, TTN, DLG1, ACTB, NF2, ELMO1, CXCL1, APBB1, RAC1, NEDD9, 657 226 15360 2.999959591061543 0.002154403940528238 2.0156133379134467E-5 7.852630182547671E-4 GOTERM_BP_ALL GO:0001525~angiogenesis 20 2.95% 1.0816376781680222E-5 TIE1, CTNNB1, FGFR1, PML, PTEN, CEACAM1, ANGPT1, FGF1, HAND1, CSPG4, HAND2, NPPB, PLG, ERBB2, MMP14, IL18, FOXO4, NPR1, THBS1, S100A7, 657 143 15360 3.2697895711594342 0.055244911755443216 3.8916775427877415E-4 0.02068953670930629 GOTERM_BP_ALL GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 22 3.24% 4.583512651796287E-6 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, APP, CNTNAP1, C5AR1, CCR4, CCL5, PLN, MYC, 657 160 15360 3.2146118721461185 0.023794177079439205 1.7077854094738054E-4 0.00876782615971683 GOTERM_BP_ALL GO:0030003~cellular cation homeostasis 22 3.24% 3.112460611832343E-5 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, APP, CNTNAP1, C5AR1, CCR4, CCL5, PLN, MYC, 657 181 15360 2.841645853830823 0.15086001621709344 9.966446382849714E-4 0.05952410530091212 GOTERM_BP_ALL GO:0030001~metal ion transport 32 4.72% 0.004894045811728672 SLC8A2, TRPC6, TRPC3, TRPC4, CAV3, KCNJ16, KCNJ6, SLC17A1, KCNA5, SLC8A1, TRPM2, SCN5A, ITPR1, SLC5A7, KCNB1, FYN, EN1, KCNK3, RYR2, CCL8, SCN3A, SLC9A3, RYR1, ACCN3, SLC22A2, KCNJ9, KCNJ15, ACCN1, PLN, KCNA3, ATP1B2, ADRB2, 657 443 15360 1.688776193862931 0.999999999993611 0.07199144724648898 8.958269105690054 GOTERM_BP_ALL GO:0001505~regulation of neurotransmitter levels 11 1.62% 0.0020916364809201128 SNPH, SNAP25, NOS1AP, PARK2, ACHE, SLC5A7, NLGN1, SNCAIP, SLC6A4, CHAT, SNCB, 657 80 15360 3.2146118721461185 0.9999833144435788 0.03588824575206173 3.9263013089091303 GOTERM_BP_ALL GO:0042221~response to chemical stimulus 56 8.26% 1.0075635016359628E-7 HSF1, CXCL2, ASIP, ABCB4, MAPK1, NOD2, MMP14, HSPB1, PDZK1, MBL2, PPARG, GPX1, PRKCG, S100A7, CXCL3, CCL8, WNT2, HSP90AA1, ELA2, HCLS1, CCR1, IL8RA, TTN, SYK, MVP, ERN1, GUCY2C, CCR4, TRH, GNAI2, PDZD3, CCL7, PRKCA, LIPE, CCR3, SERPIND1, ITGB2, CCL5, MAPK14, IL16, RAG2, CCL2, ABCB1, RYR1, RELA, AKT1, REN, ACTB, LCK, CXCL1, CNTNAP1, C5AR1, HSPA8, IL4, IRS1, HTN1, 657 606 15360 2.1604352216043523 5.29233796731643E-4 5.692176169080909E-6 1.9274519971190784E-4 GOTERM_BP_ALL GO:0001501~skeletal development 22 3.24% 7.874488300130616E-4 CTNNB1, FGFR1, ACHE, GNAQ, IGF1, NPR3, ZBTB16, HOXD10, SOX9, TWIST1, MMP14, GLI1, MYF5, COL1A2, SPP1, ROR2, EN1, HDAC4, EGFR, MMP9, ADRB2, HTN1, 657 228 15360 2.2558679804534165 0.9840593997149095 0.016354376433554974 1.4956731391516986 GOTERM_BP_ALL GO:0022610~biological adhesion 76 11.21% 1.8587918897659348E-11 DSC1, DSG3, PKP3, DSC3, PTEN, INPPL1, DDR2, MMP14, MYF5, NPHS1, SPP1, ROR2, LY9, EGFR, THBS1, ACHE, TGM2, PPFIA1, CCR1, ABL1, ERBB2IP, TTN, IL12A, SYK, ITGB3, NF2, APP, PXN, MYBPC1, IL18, KIRREL, CD44, ICAM5, NEDD9, MAGI1, HSPG2, ACTN2, ZYX, CTNNB1, APLP1, CNTN1, CASK, VAV1, KNG1, CADM1, NLGN1, CCR3, USH2A, CEACAM1, ACTN3, ITGB2, APC, APAF1, CCL5, CLSTN3, PKP2, NFASC, CCL2, CD84, ITGB1, PSTPIP1, SOX9, DLG1, ROPN1B, THBS2, CNTNAP1, STAT5A, CD2, DSG2, CD72, SELE, CDH5, RAC1, NID1, MLLT4, F11R, 657 774 15360 2.295611954739065 9.766086905838023E-8 1.8426580261632353E-9 3.555838956614821E-8 GOTERM_BP_ALL GO:0006261~DNA-dependent DNA replication 13 1.92% 0.0025577800353302127 TP53, CDC6, ABL1, NF2, RPA4, ORC2L, GLI1, HMGB2, HMGB1, CDC7, RPA1, PRKCG, HMGA1, 657 110 15360 2.762972187629722 0.9999985670741129 0.04168775575096628 4.781185137704447 GOTERM_BP_ALL GO:0022607~cellular component assembly 47 6.93% 9.441834368059115E-5 ACTN2, ASF1B, XPO1, WAS, SRC, NOD2, LLGL1, CREBBP, HIST3H3, APC, HSPB1, HMGB2, HMGB1, PEX14, MYOZ1, NPM1, HMGA1, DLG4, TAF1, ACTA1, PML, SNAP91, TGM2, PPARGC1A, TP53, MIS12, SLC9A3R1, PICALM, SET, PTK2, TRAF1, NCK1, TTN, ACTB, SYK, ITGB3, PICK1, PXN, AP2M1, CAV1, SMAD3, HCFC1, SFRS9, MAPK8IP2, ADRB2, MAGI1, CLTCL1, 657 602 15360 1.8252704076214747 0.39109766793672196 0.002580505373769859 0.18046635590908133 GOTERM_BP_ALL GO:0007275~multicellular organismal development 220 32.45% 1.79568403105954E-32 FGF8, HAP1, YY1, FHL3, NR0B1, MMP14, COL1A2, FYN, MYOZ1, RAG1, S100A7, ZBTB17, BMX, SYK, NF2, FOXH1, ADRBK1, POU3F3, ID2, BTK, NTS, WNT4, GCM1, NLGN1, USH2A, DVL1, NRIP1, ITGB2, FHL1, PTPN11, ERBB3, LEP, ADAMTS1, AGTR2, F2, ITGB1BP3, SOX9, FGF1, PTPRZ1, HOXB7, AES, CXCL1, PICK1, CD2, PAX3, CAV1, ACCN1, IL4, HOXA10, MMP9, POU3F1, MAPK1, PROX1, LMO1, DCN, IL27RA, EDA2R, ROR2, NR5A1, CRKL, THBS1, SHC3, EPHB1, ZBTB16, PPP1R9A, APP, GLI1, CCR4, HBEGF, CRYAB, EP300, SNTG2, LMO2, HMGA2, EPB42, SIAH2, PIM1, APLP1, KNG1, CADM1, WAS, TLX1, TWIST1, MYF6, STAT3, SALL1, ERC2, APBA2, HOXB2, PAX5, PKP2, SFRP1, CHAT, FGF13, NFASC, NTRK1, GRN, PRKG1, IRF8, HCK, RYR1, HOXD10, HAND2, CRX, FOXO1, POU3F2, HDAC4, CEBPB, PLN, PAX2, RTN4, NOS3, HTN1, ASF1B, DYRK1A, CAV3, MEOX2, PLG, SPP1, WNT1, EMX2, FOXO4, RYBP, ALK, DLG4, WNT2, TGM2, NPR3, PPARA, KLF1, TTN, ITGB3, LRP1, MYBPC1, FOS, PARK2, HOXD4, NOTCH1, KRT17, IGFBP3, EYA1, ADRB2, TBR1, IGF1, TCL1A, ANGPT1, FGF7, PLP1, CASQ2, IFI16, ERBB2, APAF1, AR, CCL2, AKT1, TFAP2B, ACTB, STAT5A, SGCG, SMAD3, CDH5, NPR1, TGM1, PSEN2, EPHB2, IKZF1, FGFR1, GNAQ, PTEN, TAL1, LHX3, NEUROD1, PRL, MYF5, FZD1, EGFR, ZAP70, PML, ACHE, CASP3, ANKRD2, HCLS1, NDN, PIK3R1, DCX, CSPG4, NPPB, HOXA9, LRP2, IL18, NHLH1, ZEB1, ADD2, CD44, FES, CTNNB1, CITED2, CEACAM1, E2F1, APC, NGFR, EN1, NFE2, RAG2, TIE1, ACTA1, FGD1, MEIS1, TP53, SH3GL2, RELA, ITGB1, SIX3, HAND1, CSF1R, NR5A2, LCK, APBB1, PLCG1, ASCL1, 657 2349 15360 2.1896036591885015 9.434523899186823E-29 1.8869047798373644E-29 3.4351164247081396E-29 GOTERM_BP_ALL GO:0050896~response to stimulus 190 28.02% 1.8462682649256037E-8 CXCL2, HSF1, RPGRIP1, TRPC3, XPO1, DARC, ITCH, NOD2, POU2AF1, OPN1LW, PTPN6, STAT1, TNFRSF25, PLG, UPF1, MMP14, PDC, HSPB1, HMGB2, HMGB1, PTX3, FYN, GRK1, FOXO4, PRKCG, RAG1, S100A7, DLG4, CIITA, CCL8, WNT2, TGM2, NTSR1, CD48, ADRA2A, PPARA, TTN, ARRB2, IL12A, SYK, ITGB3, EBI3, IL4R, PARK2, TNIK, FOS, NOTCH1, GNAI2, GZMA, PDZD3, ADRB2, IL18R1, RFX1, RHO, VAV1, HLA-DRA, RPGR, USH2A, FGF7, IFI16, CD244, ITGB2, PTPN11, RPA1, MAPK14, CRHBP, GSK3B, IL16, LEP, CCL2, FCGR2B, AGTR2, CD84, ITIH4, C1QBP, TYROBP, TUBB, F2, CTSB, AKT1, REN, ACTB, CXCL1, STAT5A, SMAD3, SELE, TNFRSF1B, IL4, MAPK8, CD28, RBP4, ASIP, OPRD1, ABCB4, GNAQ, MAPK1, INPPL1, IL27RA, CREBBP, FCGR3A, PDE6G, SH2D1A, BFSP2, PDZK1, PPARG, MBL2, LY9, GPX1, EGFR, NPM1, THBS1, CXCL3, ACHE, PML, ZAP70, PPARGC1A, CASP3, HSP90AA1, HCLS1, ELA2, SHC3, CCR1, ABL1, IL8RA, TSHR, MVP, ERN1, APP, NCF2, INPP5D, CCR4, GUCY2C, IL18, TRH, HBEGF, ZEB1, SAG, EP300, LCP2, CCL7, PRKCA, C1QA, CDC2, WAS, CADM1, LIPE, KNG1, CITED2, CCR3, SERPIND1, CD46, PSMB9, FGR, STAT3, APC, NGFR, PLA2G7, PAX5, CCL5, EN1, CHAT, BEST1, RAG2, CTSG, DDO, IRF8, ABCB1, TP53, RYR1, RELA, ITGB1, SMAD7, CRX, LCK, CAMP, MX1, CNTNAP1, C5AR1, RAC1, HDAC4, CEBPB, HSPA8, APOH, KIR3DL1, RAB27A, F11R, CR2, NOS3, IRS1, HTN1, 657 3066 15360 1.4487961945271008 9.699823066933178E-5 1.3108496178526607E-6 3.531882700746891E-5 GOTERM_BP_ALL GO:0007268~synaptic transmission 30 4.42% 4.588578028665844E-5 CTNNB1, NOS1AP, DLGAP2, MAPK1, NLGN1, SNCAIP, HAP1, SLC6A4, NOS1, PLP1, SLC5A7, KCNK3, CHAT, PNOC, SNCB, DLG4, ACHE, WNT2, STX1A, NTSR1, SHC3, KIF5A, BSN, SNPH, SNAP25, PARK2, ACCN1, CAMK4, AKAP5, HOMER1, 657 304 15360 2.3071377072819033 0.2142286411797134 0.0013688884716981375 0.08774230238084435 GOTERM_BP_ALL GO:0007267~cell-cell signaling 74 10.91% 5.887159597751466E-14 POU3F1, ASIP, GNAQ, FGF8, MAPK1, NOS1, HAP1, IAPP, GRAP, SLC5A7, SH2D1A, TEK, FZD1, PCSK2, KCNK3, NR5A1, GJA3, FGFBP1, SNCB, DLG4, CCL8, WNT2, ACHE, NTSR1, SHC3, CCR1, BSN, TSHR, SYK, SNPH, PARK2, GLI1, MME, SCG5, IL18, TRH, CAMK4, AREG, WNT4, HOMER1, ADCYAP1, ZYX, CTNNB1, NOS1AP, VIPR2, DLGAP2, CCL7, C1QA, FURIN, NLGN1, SNCAIP, SLC6A4, FGF7, PLP1, ITGB2, GRAP2, PCSK1, SALL1, ERBB2, CCL5, CHAT, PNOC, AR, FGF13, LEP, GRN, CCL2, STX1A, KIF5A, FGF1, SNAP25, ACCN1, MLLT4, AKAP5, 657 661 15360 2.6173156764000853 3.0915492388317034E-10 8.355538483328928E-12 1.1256551246674462E-10 GOTERM_BP_ALL GO:0022414~reproductive process 27 3.98% 6.508728537929357E-4 CD28, AKAP3, LIPE, ITCH, CEACAM1, CD46, NRIP1, NR0B1, PRL, CTBP1, MMP14, ROR2, AR, NR5A1, CRHBP, GRN, CCL2, DDO, ADAMTS1, WNT2, SOX9, ROPN1B, STAT5A, SMAD3, NOS3, HCFC1, ADCYAP1, 657 305 15360 2.06961598922075 0.9673137032109906 0.013921851548985176 1.2377908777851832 GOTERM_BP_ALL GO:0050880~regulation of blood vessel size 8 1.18% 0.0018378905345538292 NPPB, WNT2, AGTR2, CAV1, KNG1, NPR1, NTS, ADRB2, 657 42 15360 4.4531419873885625 0.999936543843918 0.032448764403634534 3.4578916368744217 GOTERM_BP_ALL GO:0050878~regulation of body fluid levels 14 2.06% 0.0022940028139476214 GNAQ, KNG1, WAS, F2, SERPIND1, ITGB3, SLC22A2, NPPB, PLG, NFE2, APOH, NPR1, RAB27A, THBS1, 657 123 15360 2.6610238705126776 0.9999942512977049 0.03879004130151942 4.298320621897622 GOTERM_BP_ALL GO:0007260~tyrosine phosphorylation of STAT protein 6 0.88% 0.0016098037801608104 STAT1, HCLS1, F2, IL4, IL12A, NF2, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0050877~neurological system process 71 10.47% 0.003312630247936747 POU3F1, RBP4, RPGRIP1, TRPC3, OPRD1, GNAQ, MAPK1, HAP1, NOS1, OPN1LW, IAPP, SLC5A7, PDE6G, PDC, BFSP2, COL1A2, GRK1, KCNK3, GJA3, SNCB, DLG4, WNT2, ACHE, NTSR1, SHC3, NDN, BSN, ARRB2, ACCN3, NF2, SNPH, APP, PARK2, CAMK4, CRYAB, SAG, EYA1, HOMER1, ADRB2, CTNNB1, NOS1AP, DLGAP2, IGF1, RHO, NLGN1, SNCAIP, RPGR, SLC6A4, USH2A, PLP1, ERBB2, PTPN11, EN1, CHAT, PNOC, BEST1, OPRL1, AGTR2, STX1A, KIF5A, ACTB, SIX3, CRX, SNAP25, PAX3, C5AR1, ACCN1, SOX10, PAX2, GNG13, AKAP5, 657 1185 15360 1.4007668150203263 0.9999999731620949 0.052384970503703276 6.150270899340427 GOTERM_BP_ALL GO:0007259~JAK-STAT cascade 10 1.47% 6.845843565506175E-5 CCL2, STAT3, STAT1, STAT5A, HCLS1, HGS, F2, IL4, IL12A, NF2, 657 43 15360 5.436975682276733 0.30210940771296646 0.0019529434167026016 0.13087871510202298 GOTERM_BP_ALL GO:0050870~positive regulation of T cell activation 12 1.77% 2.1348075755437485E-6 CD28, EBI3, LCK, STAT5A, ZAP70, CD5, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 45 15360 6.2343987823439875 0.011153622902296156 8.627543939832005E-5 0.004083775612939711 GOTERM_BP_ALL GO:0007254~JNK cascade 11 1.62% 5.173555120676312E-4 MAPK10, TNIK, ROR2, MAPK8IP1, MAPK8, CRKL, MAPK8IP2, SYK, SH2D3C, PAK1, EDA2R, 657 67 15360 3.8383425339058133 0.9340520336959152 0.011551942731621523 0.9850655094310601 GOTERM_BP_ALL GO:0022402~cell cycle process 63 9.29% 4.076706774558337E-7 CD28, INCENP, RAP1A, PTEN, FGF8, CALR, STAT1, RUNX3, CDK3, FOXO4, EGFR, NEK2, NPM1, CDKN3, TAF1, PML, CASP3, ZBTB17, NDN, ABL1, TTN, NF2, ACPP, ERN1, UBE2I, MOS, C13orf15, HCFC1, NEDD9, ADCYAP1, PRKCA, CCNA1, CDC2, CADM1, CITED2, FGF7, E2F1, APC, RPA1, PTPN11, DNM2, AXL, NDC80, SHC1, MYC, YEATS4, CCNT1, TP53, MIS12, RYR1, F2, STARD13, CDC6, FGF1, DLG1, LCK, STAT5A, APBB1, CDC7, NME1, COPS5, EPHB2, WT1, 657 749 15360 1.9664575598514915 0.0021396099402630764 2.0206420148105586E-5 7.7986496541671E-4 GOTERM_BP_ALL GO:0050865~regulation of cell activation 16 2.36% 4.276170135951222E-6 CD28, CD5, ZAP70, CASP3, NCK1, SYK, IL27RA, IL12A, LCK, EBI3, STAT5A, CD2, ERBB2, IL18, PRKCQ, IL4, 657 88 15360 4.250726442507265 0.02221654139397966 1.6162036198563712E-4 0.008179931787133388 GOTERM_BP_ALL GO:0050863~regulation of T cell activation 14 2.06% 2.4557290455367003E-6 CD28, CD5, ZAP70, NCK1, SYK, IL12A, LCK, EBI3, STAT5A, CD2, ERBB2, IL18, PRKCQ, IL4, 657 64 15360 5.114155251141552 0.012819536906119033 9.77408006914704E-5 0.004697667990760657 GOTERM_BP_ALL GO:0007243~protein kinase cascade 52 7.67% 1.140121110220438E-12 FGFR1, MAPK1, PTEN, CAV3, SRC, NOD2, REL, EDA2R, STAT1, PDE6G, FYN, ROR2, HGS, CRKL, ZAP70, TGM2, HCLS1, ADRA2A, CASP1, SYK, IL12A, NF2, SH2D3C, RGS4, TNIK, SNF1LK2, ADRB2, PRKCA, TEC, PAK1, STAT3, PTPN11, MAPK14, SHC1, FGF13, BLK, CCL2, MAPK10, MAPKAPK2, DAPK1, F2, RELA, AKT1, REN, STAT5A, C5AR1, CAV1, MAPK8IP1, IL4, MAPK8, MAPK8IP2, IRS1, 657 393 15360 3.0934039759722074 5.99002247803071E-9 1.42619582810255E-10 2.1809665184946425E-9 GOTERM_BP_ALL GO:0007242~intracellular signaling cascade 152 22.42% 6.140256764354717E-25 PRKCZ, RAP1A, CAV3, SRC, NOD2, PTPN6, FHL2, CASP9, GRAP, PLCD1, STAT1, CAP1, HMGB2, FYN, PRKCG, YWHAE, TGM2, NPR3, ADRA2A, BMX, IL12A, RGS19, SYK, ELMO1, CA8, NF2, RGS4, S100A1, TNIK, BTK, SNF1LK2, GNAI2, GZMA, GNB2L1, KSR1, HOMER1, PDZD3, ADRB2, IGF1, VAV1, DVL1, NRIP1, GRAP2, PRKCE, DOK3, ERBB2, APAF1, SOS1, PTPN11, MAPK14, GSK3B, NDC80, CASP2, CCL2, MAPK10, TYROBP, RAB3B, F2, AKT1, REN, TXK, CXCL1, STAT5A, PICK1, CAV1, SMAD3, NPR1, PSEN2, IL4, MAPK8, GNA15, ASIP, FGFR1, OPRD1, IQGAP2, GNAQ, PTEN, MAPK1, INPPL1, REL, EDA2R, GUCY1B3, PDE6G, SH2D1A, HGS, ROR2, GPX1, EGFR, CRKL, ZAP70, GUCY1A2, PPARGC1A, CASP3, HCLS1, SHC3, PIK3R1, CCR1, CASP1, DCX, ABL1, TSHR, SH2D3C, ERN1, INPP5D, GUCY2C, TRH, PRKCQ, ARHGEF7, ADCYAP1, FES, CTNNB1, SIAH2, LCP2, PRKCA, BCL2L1, TEC, CBLC, CCR3, PRKAR2A, SHC2, SLA, PAK1, STAT3, FGR, SHC1, FGF13, BLK, BCL2L10, NCOA1, OPRL1, HCK, FGD1, TP53, MAPKAPK2, RYR1, DAPK1, RELA, NCK1, IQGAP1, ROPN1B, LCK, PLCG1, C5AR1, RAC1, MAPK8IP1, RAB27A, AKAP13, GNG13, MAPK8IP2, IRS1, CBL, NCOA2, 657 1496 15360 2.3754059531658243 3.2260909039919683E-21 2.0163068149949802E-22 1.1746218431710705E-21 GOTERM_BP_ALL GO:0009653~anatomical structure morphogenesis 114 16.81% 4.0564362957031055E-18 FGF8, ITCH, LLGL1, YY1, CAP1, PLG, MMP14, KRT18, FYN, WNT1, POU5F1, FOXO4, S100A7, WNT2, TGM2, KLF1, SYK, NOTCH1, IGFBP3, NTS, EYA1, GCM1, CLTCL1, NEDD9, ADRB2, IGF1, ANGPT1, DVL1, ITGB2, FHL1, ERBB2, APAF1, PTPN11, AR, CCL2, AGTR2, JUN, CASC5, AKT1, FGF1, PTPRZ1, DLG1, AES, STAT5A, PAX3, CAV1, SMAD3, NPR1, TGM1, SPTA1, FGFR1, GNAQ, PTEN, MAPK1, PROX1, LHX3, DCN, IGFBP5, MYF5, FZD1, PPARG, ROR2, CRKL, THBS1, PML, NDN, ZBTB16, ERBB2IP, AKAP2, CSPG4, NPPB, GLI1, IL18, PRKCQ, ZEB1, EP300, CD44, ACTN2, EPB42, CTNNB1, APLP1, KNG1, TLX1, CEACAM1, TWIST1, SALL1, NGFR, PAX5, EN1, SFRP1, CHAT, SHC1, NFASC, TIE1, PRKG1, YEATS4, FGD1, TP53, RELA, NCK1, HAND1, HAND2, NR5A2, CRX, IGFBP1, APBB1, CA9, POU3F2, RAC1, CEBPB, SOX10, PAX2, F11R, RTN4, 657 1133 15360 2.3523437594457675 2.1312516297624116E-14 6.660161343007536E-16 7.759901354655393E-15 GOTERM_BP_ALL GO:0022008~neurogenesis 28 4.13% 4.101606212752689E-4 GNAQ, PTEN, TLX1, NLGN1, TWIST1, MMP14, NGFR, FYN, PTPN11, EN1, EMX2, CHAT, NFASC, PRKG1, WNT2, NDN, PTPRZ1, NF2, APP, PICK1, APBB1, CCR4, POU3F2, CEBPB, ASCL1, PAX2, RTN4, GCM1, 657 312 15360 2.0981149748273036 0.8841461701358755 0.009327642380350998 0.7817205762065016 GOTERM_BP_ALL GO:0000902~cell morphogenesis 43 6.34% 2.1789221238019005E-5 ACTN2, SPTA1, EPB42, CTNNB1, FGFR1, PTEN, ITCH, LLGL1, ITGB2, FHL1, IGFBP5, CAP1, NGFR, FYN, WNT1, PTPN11, CHAT, AR, SHC1, NFASC, PRKG1, YEATS4, PML, FGD1, TP53, NDN, NCK1, ERBB2IP, DLG1, AKAP2, PTPRZ1, NPPB, IGFBP1, APBB1, POU3F2, RAC1, SMAD3, PRKCQ, NPR1, PAX2, RTN4, IGFBP3, NEDD9, 657 499 15360 2.01462285301196 0.10817184439046867 7.335885846867507E-4 0.04167421907149693 GOTERM_BP_ALL GO:0007229~integrin-mediated signaling pathway 10 1.47% 0.0034421594224623058 ADAMTS1, VAV1, PTK2, CEACAM1, ITGB1, ERBB2IP, SYK, ITGB3, NEDD9, ITGB2, 657 72 15360 3.2470826991374935 0.9999999864421907 0.054217329151831306 6.383316899710378 GOTERM_BP_ALL GO:0046651~lymphocyte proliferation 13 1.92% 3.6464512657869886E-5 CD28, CASP3, CADM1, RYR1, NCK1, SYK, IL12A, EBI3, STAT5A, ERBB2, IL18, PRKCQ, IL4, 657 70 15360 4.341813437703848 0.17435307020236146 0.0011263536729020363 0.06973300892875178 GOTERM_BP_ALL GO:0016055~Wnt receptor signaling pathway 17 2.51% 9.188750377149216E-5 CTNNB1, WNT2, CXXC4, SLC9A3R1, PORCN, SIX3, DVL1, LRP1, AES, APC, CSNK2A1, FZD1, ROR2, WNT1, SFRP1, GSK3B, WNT4, 657 126 15360 3.154308907733565 0.38294623948574413 0.0025245520641219432 0.1756330673643336 GOTERM_BP_ALL GO:0046649~lymphocyte activation 28 4.13% 2.1812100239596017E-8 CD28, CD5, WAS, CADM1, VAV1, IL27RA, ERBB2, RAG1, NTRK1, RAG2, ZAP70, CASP3, RYR1, PIK3R1, NCK1, SYK, IL12A, LCK, EBI3, SLAMF1, STAT5A, CD2, IL18, SMAD3, PRKCQ, HDAC4, KIR3DL1, IL4, 657 185 15360 3.538442552141182 1.1459420947756982E-4 1.507903809150335E-6 4.172620999831622E-5 GOTERM_BP_ALL GO:0042129~regulation of T cell proliferation 10 1.47% 1.4934880268622296E-5 CD28, EBI3, STAT5A, ERBB2, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 36 15360 6.494165398274987 0.07546876869407271 5.195235895439909E-4 0.02856633273269349 GOTERM_BP_ALL GO:0042127~regulation of cell proliferation 69 10.18% 8.46761802816014E-18 CD28, HSF1, FGFR1, PTEN, PROX1, PTPN6, PRL, PLG, RUNX3, DDR2, BTC, HGS, FOXO4, EGFR, GPX1, NPM1, CDKN3, PAWR, FGFBP1, WNT2, TGM2, CASP3, HCLS1, ELA2, NDN, ADRA2A, ZBTB16, TSHR, SYK, IL12A, NF2, EBI3, SLAMF1, GLI1, IL18, PRKCQ, NOTCH1, HBEGF, ADRB2, CTNNB1, IGF1, TLX1, ABI1, FGF7, APC, CTBP1, ERBB2, PRTN3, SHC1, MYC, GRN, ADAMTS1, TP53, MAGED1, NCK1, CDC6, SOX9, FOXO1, CXCL1, STAT5A, CAV1, CDC7, POU3F2, SMAD3, CDH5, NME1, HDAC4, IL4, NOS3, 657 499 15360 3.2327669036703544 4.448886511995338E-14 1.3084960329398051E-15 1.6198425370818034E-14 GOTERM_BP_ALL GO:0016049~cell growth 19 2.80% 0.0014889444313388393 FGFR1, YEATS4, PML, TP53, ITCH, NDN, ERBB2IP, NPPB, FHL1, IGFBP5, IGFBP1, APBB1, SMAD3, PRKCQ, NPR1, IGFBP3, AR, SHC1, NEDD9, 657 192 15360 2.313546423135464 0.9996018746975234 0.027866961395012768 2.8102087302713574 GOTERM_BP_ALL GO:0006182~cGMP biosynthetic process 5 0.74% 0.0012399214644084893 GUCY1B3, GUCY1A2, GUCY2C, NPR1, PDZD3, 657 12 15360 9.74124809741248 0.9985242507900077 0.02429837447908889 2.345478599782802 GOTERM_BP_ALL GO:0016044~membrane organization and biogenesis 30 4.42% 2.6457730948590176E-5 APLP1, BCL2L1, CAV3, VAV1, NLGN1, CAP1, PTX3, DNM2, EGFR, EHD2, TIE1, SNAP91, SYNJ1, SLC9A3, TP53, ELA2, SH3GL2, RYR1, PICALM, ELMO1, ROPN1B, APP, LRP1, PICK1, LRP2, CD2, RAC1, CBL, CLTCL1, ADRB2, 657 295 15360 2.3775249593684697 0.12978133285319204 8.684399211273952E-4 0.05060110250709737 GOTERM_BP_ALL GO:0016043~cellular component organization and biogenesis 189 27.88% 1.254009912372701E-12 PRKCZ, ASF1B, KIF17, XPO1, CAV3, ITCH, SRC, NOD2, LLGL1, HAP1, ACTL6B, FHL3, STAT1, CAP1, KRT18, FHOD1, UPF1, HSPB1, HMGB2, HMGB1, PTX3, FYN, WNT1, MYOZ1, NEK2, HMGA1, DLG4, CCL8, WNT2, TGM2, SATB1, SLC9A3R1, PTK2, ADRA2A, TTN, KLF1, SYK, ELMO1, ITGB3, NF2, SNPH, LRP1, PARK2, PXN, CAMK4, GZMA, IGFBP3, HCFC1, SFRS9, ADRB2, NEDD9, CLTCL1, NOS1AP, AKAP3, VAV1, NLGN1, SNCAIP, RPGR, DOT1L, HIST3H3, ITGB2, FHL1, FMNL1, YWHAB, PTPN11, DNM2, EXOSC4, NDC80, SYNPO, GSK3B, AR, MYRIP, EHD2, EXOSC1, PICALM, RAB3B, TUBB, F2, AKT1, ACTB, DLG1, PTPRZ1, TUBA1A, HDAC1, SNAP25, CXCL1, PICK1, CD2, TUBA8, SGCG, AP2M1, CAV1, SMAD3, TGM1, NPR1, MMP9, SPTA1, FGFR1, PTEN, CALR, CREBBP, IGFBP5, NXF3, BFSP2, MYF5, CBX5, HGS, GPX1, EGFR, NPM1, CBX2, DNAJC1, TAF1, ACHE, PML, EPB41L3, PPARGC1A, CASP3, HSP90AA1, ELA2, SET, NDN, ABL1, PPP1R9A, ERBB2IP, VIM, AKAP2, MVP, NPPB, APP, LRP2, RPH3AL, SCG5, PRKCQ, CRYAB, EP300, MAGI1, ACTN2, HMGA2, EPB42, CTNNB1, LCP2, APLP1, BCL2L1, WAS, CADM1, KISS1, PAK1, APC, NGFR, ERC2, PIGR, PEX14, CCL5, MYH4, CHAT, STX12, SHC1, NFASC, PRKG1, TIE1, ACTA1, YEATS4, SNAP91, STX1A, SYNJ1, FGD1, SLC9A3, TP53, MIS12, CNN1, SH3GL2, RYR1, TRAF1, NCK1, KIF5A, ROPN1B, SHANK1, IGFBP1, APBB1, POU3F2, RAC1, HDAC4, RAB27A, PAX2, RTN4, MAPK8IP2, AKAP5, CBL, 657 2723 15360 1.6227066239391483 6.588499745774357E-9 1.532208804277957E-10 2.3988810937680682E-9 GOTERM_BP_ALL GO:0042113~B cell activation 11 1.62% 6.571226582084646E-4 RAG2, STAT5A, CASP3, HDAC4, RYR1, PIK3R1, IL4, RAG1, IL27RA, SYK, NTRK1, 657 69 15360 3.72708622857521 0.9683702551618624 0.013885118268344154 1.2496056922181698 GOTERM_BP_ALL GO:0042110~T cell activation 19 2.80% 2.247035336770724E-6 CD28, RAG2, CD5, ZAP70, VAV1, CADM1, WAS, NCK1, IL12A, SYK, LCK, EBI3, STAT5A, ERBB2, CD2, IL18, SMAD3, PRKCQ, IL4, 657 117 15360 3.796589002068454 0.01173652029506611 9.011759507193684E-5 0.004298457097384745 GOTERM_BP_ALL GO:0042108~positive regulation of cytokine biosynthetic process 8 1.18% 0.0021158470677404466 CD28, EBI3, STAT5A, ELA2, PRKCQ, RELA, SYK, REL, 657 43 15360 4.349580545821387 0.9999853113825329 0.03617846522421497 3.970880809030053 GOTERM_BP_ALL GO:0009628~response to abiotic stimulus 17 2.51% 0.002411883057392422 PML, TRPC3, RHO, ELA2, AKT1, RELA, OPN1LW, IL12A, MMP14, PDC, NGFR, IL18, GRK1, GPX1, MAPK8, SAG, ADRB2, 657 169 15360 2.3517332684877466 0.999996910001435 0.03997437795465186 4.514395592153453 GOTERM_BP_ALL GO:0042107~cytokine metabolic process 11 1.62% 0.0014121027320912066 CD28, EBI3, STAT5A, IL18, ELA2, PRKCQ, CEBPB, IL4, RELA, SYK, REL, 657 76 15360 3.383801970680125 0.9994034998223801 0.026926541057585074 2.6670297500844042 GOTERM_BP_ALL GO:0007204~elevation of cytosolic calcium ion concentration 11 1.62% 5.837893735235572E-4 GNA15, LCK, TRPC6, CNTNAP1, OPRL1, TGM2, C5AR1, CCR4, KNG1, CCR1, CCR3, 657 68 15360 3.7818963201719042 0.9534917249914686 0.012598172741019265 1.1108898982029713 GOTERM_BP_ALL GO:0042102~positive regulation of T cell proliferation 9 1.33% 1.1439151730093679E-5 CD28, EBI3, STAT5A, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 27 15360 7.792998477929984 0.05833118903977774 4.087711714220177E-4 0.02188065545010165 GOTERM_BP_ALL GO:0042098~T cell proliferation 11 1.62% 4.1159751236739005E-5 CD28, EBI3, STAT5A, ERBB2, IL18, CADM1, PRKCQ, IL4, NCK1, IL12A, SYK, 657 50 15360 5.14337899543379 0.1944723766933677 0.0012349955279160607 0.07870861130319096 GOTERM_BP_ALL GO:0009611~response to wounding 52 7.67% 3.7496180483965816E-11 CXCL2, GNAQ, ITCH, PTPN6, PLG, PTX3, MBL2, THBS1, CXCL3, CCL8, ACHE, TGM2, CASP3, ELA2, CCR1, IL8RA, ITGB3, FOS, CCR4, HBEGF, ADRB2, CCL7, PRKCA, C1QA, KNG1, WAS, CCR3, FGF7, SERPIND1, CD46, ITGB2, STAT3, NGFR, PLA2G7, CCL5, CCL2, ITIH4, CTSB, F2, RELA, AKT1, CXCL1, STAT5A, SELE, RAC1, TNFRSF1B, HDAC4, APOH, CEBPB, RAB27A, F11R, CR2, 657 431 15360 2.8206676625454237 1.9700516429299597E-7 3.648244151222002E-9 7.172972216196172E-8 GOTERM_BP_ALL GO:0042089~cytokine biosynthetic process 11 1.62% 0.001273952231271368 CD28, EBI3, STAT5A, IL18, ELA2, PRKCQ, CEBPB, IL4, RELA, SYK, REL, 657 75 15360 3.428919330289193 0.9987661453504384 0.02468139802526126 2.409111295574584 GOTERM_BP_ALL GO:0065009~regulation of a molecular function 57 8.41% 1.7037388651808107E-9 GNA15, GNAQ, PTEN, CAV3, NOD2, EDA2R, CASP9, STAT1, CAP1, PDE6G, EGFR, GPX1, CDKN3, NPM1, CASP3, ELA2, SLC9A3R1, ADRA2A, ABL1, SYK, ERN1, RGS4, ID2, PRKCQ, CAMK2A, C13orf15, GNAI2, GNB2L1, EP300, ADCYAP1, ADRB2, NOS1AP, PRKCA, CCNA1, VAV1, CBLC, APC, ERBB2, APAF1, PEX14, PTPN11, SHC1, BCL2L10, CCNT1, FGD1, TP53, CTSB, F2, RELA, CDC6, LCK, PICK1, C5AR1, CAV1, SMAD3, PSEN2, IRS1, 657 554 15360 2.405420107808714 8.95140368650793E-6 1.3562792644528088E-7 3.2592265664099784E-6 GOTERM_BP_ALL GO:0065008~regulation of biological quality 87 12.83% 3.359696778457713E-13 SPTA1, POU3F1, GNA15, FGFR1, GNAQ, PTEN, CAV3, ITCH, CALR, CREBBP, IAPP, IGFBP5, PLG, GRK1, GPX1, THBS1, WNT2, PML, TGM2, PPARGC1A, CASP3, ELA2, SLC9A3R1, NPR3, NDN, CCR1, ERBB2IP, SLC22A2, ITGB3, NPPB, APP, CCR4, PRKCQ, IGFBP3, NTS, EP300, ADRB2, NEDD9, TRPC6, CTNNB1, CCL7, PRKCA, BCL2L1, KNG1, WAS, CCR3, USH2A, SERPIND1, PLP1, KCNA5, FHL1, ERBB2, CCL5, NFE2, STX12, SLC2A4, AR, SHC1, LEP, MYC, CCL2, RYR2, YEATS4, OPRL1, AGTR2, SLC9A3, TP53, MAPKAPK2, RYR1, F2, AKT1, NCK1, REN, NR5A2, LCK, IGFBP1, CNTNAP1, STAT5A, APBB1, C5AR1, CAV1, SMAD3, TNFRSF1B, PLN, NPR1, APOH, RAB27A, 657 881 15360 2.3087089701926513 1.7650996220197612E-9 4.305122924819216E-11 6.426748022647644E-10 GOTERM_BP_ALL GO:0050801~ion homeostasis 30 4.42% 3.0433078161581995E-7 TRPC6, GNA15, CCL7, BCL2L1, PRKCA, CAV3, KNG1, CCR3, CALR, KCNA5, CCL5, GRK1, MYC, CCL2, RYR2, OPRL1, TGM2, SLC9A3, SLC9A3R1, ELA2, RYR1, CCR1, LCK, NPPB, APP, CNTNAP1, C5AR1, CCR4, NPR1, PLN, 657 236 15360 2.9719061992105873 0.001597676523540481 1.583110408975852E-5 5.821785816650937E-4 GOTERM_BP_ALL GO:0065007~biological regulation 366 53.98% 4.027663287737767E-31 HSF1, FGF8, ITCH, NOD2, POU2AF1, PTPN6, YY1, NR0B1, CASP9, STAT1, CAP1, TNFRSF25, KRT18, SLC5A7, MMP14, UPF1, CDK3, PTX3, HMGB1, FYN, POU5F1, PRKCG, TPM3, ZBTB17, SLC9A3R1, ADRA2A, SYK, NF2, EBI3, FOXH1, ADRBK1, POU3F3, ID2, BTK, C13orf15, NTS, GNB2L1, GCM1, NEDD9, TRPC6, CD5, RGS2, VAV1, ABI1, NLGN1, SLC6A4, USH2A, NRIP1, ITGB2, FHL1, PRKCE, CTBP1, DNMT3A, SOS1, PTPN11, LEP, CD38, AGTR2, ADAMTS1, RAB3B, TUBB, JUN, CTSB, F2, SOX9, ITGB1BP3, KHDRBS2, DLG1, FGF1, CXCL1, AES, HOXB7, PICK1, PAX3, CD2, CAV1, TNFRSF1B, IL4, HOXA10, TCF4, MMP9, GNA15, POU3F1, SPTA1, MAPK1, PROX1, IL27RA, REL, EDA2R, IGFBP5, RUNX3, PDE6G, BTC, NR5A1, RXRG, FGFBP1, THBS1, SNCB, CBX2, HSP90AA1, ELA2, ZBTB16, CCR1, AKAP2, SLAMF1, APP, GLI1, PAK7, CCR4, SCG5, MOS, PRKCQ, CRYAB, HBEGF, EP300, LMO2, ADCYAP1, ACTN2, HMGA2, EPB42, DLGAP2, APLP1, CCL7, PIM1, CITED1, C1QA, CDC2, TLX1, WAS, CADM1, KNG1, PIAS3, ACTN3, MYF6, TWIST1, SCN5A, STAT3, SALL1, PAX5, HOXB2, PEX14, SFRP1, HABP4, CHAT, SHC1, GRN, PRKG1, NCOA1, YEATS4, OPRL1, IRF8, STAR, RYR1, TRAF1, HOXD10, HAND2, IQGAP1, SMAD7, CRX, FOXO1, POU3F2, RAC1, HDAC4, NME1, CNOT3, PLN, APOH, CEBPB, PAX2, SOX10, AKAP13, RTN4, WT1, NOS3, IKZF4, MAPK8IP2, CBL, PRKCZ, ASF1B, RAP1A, CAV3, SLC8A1, FHL2, MEOX2, YBX1, PLG, HMGB2, HSPB1, SPP1, GRK1, FOXO4, EMX2, RYBP, NEK2, CDKN3, HMGA1, CIITA, WNT2, TGM2, SATB1, NPR3, PPARA, KLF1, IL12A, RGS19, ITGB3, ACPP, RGS4, SNPH, LRP1, S100A1, PARK2, FOS, HOXD4, SP4, TRAF3, SNF1LK2, NOTCH1, ZNF238, GNAI2, IGFBP3, HCFC1, EYA1, PDZD3, ADRB2, TBR1, NOS1AP, RFX1, IGF1, FURIN, SNCAIP, FGF7, PLP1, KCNA5, IFI16, CAND2, IKZF2, ORC2L, ERBB2, APAF1, DNM2, PRTN3, AXL, GSK3B, AR, CASP2, IL16, CCL2, CCNT1, AKT1, CDC6, REN, TFAP2B, HDAC1, SNAP25, STAT5A, CDH5, SMAD3, NPR1, PSEN2, MAPK8, EPHB2, IKZF1, CD28, RUNX1T1, FGFR1, IQGAP2, GNAQ, PTEN, POU2F1, TAL1, LHX3, MLLT10, CALR, CREBBP, IAPP, NEUROD1, PRL, DDR2, MYF5, FZD1, PPARG, MBL2, HGS, GPX1, EGFR, NPM1, PAWR, DNAJC1, TAF1, SEPT4, ACHE, PML, ZAP70, PPARGC1A, CASP3, HCLS1, SET, PIK3R1, NDN, CASP1, ABL1, ERBB2IP, TSHR, SLC22A2, ERN1, NPPB, HOXA9, IL18, NHLH1, CAMK2A, ZEB1, ARHGEF7, CTNNB1, CXXC4, PRKCA, CCNA1, BCL2L1, CBLC, CITED2, CCR3, SERPIND1, CD46, E2F1, APC, NGFR, CCL5, EN1, NFE2, STX12, SLC2A4, MYC, BCL2L10, TIE1, RYR2, MLLT1, STX1A, FGD1, MEIS1, SLC9A3, TP53, MAPKAPK2, CNN1, DAPK1, STARD13, MAGED1, RELA, HIVEP3, NCK1, SIX3, HAND1, NR5A2, LCK, MX1, IGFBP1, CNTNAP1, APBB1, C5AR1, CDC7, MAPK8IP1, RAB27A, COPS5, ASCL1, CR2, IRS1, NCOA2, 657 5238 15360 1.6335838733805121 2.1161342913774228E-27 3.0230489876820326E-28 7.7048590250804785E-28 GOTERM_BP_ALL GO:0009605~response to external stimulus 73 10.77% 4.749640520276806E-14 CXCL2, TRPC3, GNAQ, MAPK1, ITCH, NOD2, PTPN6, OPN1LW, PLG, MMP14, PDC, PTX3, PPARG, MBL2, GRK1, THBS1, CXCL3, CCL8, ACHE, TGM2, PPARGC1A, CASP3, ELA2, CCR1, IL8RA, SYK, ITGB3, PARK2, FOS, CCR4, GNAI2, HBEGF, SAG, ADRB2, CCL7, PRKCA, RHO, C1QA, WAS, KNG1, CCR3, SERPIND1, FGF7, CD46, ITGB2, STAT3, NGFR, PLA2G7, CCL5, MAPK14, IL16, LEP, CCL2, ITIH4, TP53, CTSB, F2, AKT1, RELA, CXCL1, CNTNAP1, STAT5A, C5AR1, SELE, RAC1, TNFRSF1B, HDAC4, APOH, CEBPB, RAB27A, IL4, F11R, CR2, 657 644 15360 2.650103519668737 2.496571838150885E-10 6.934897101018578E-12 9.090506125630782E-11 GOTERM_BP_ALL GO:0007188~G-protein signaling, coupled to cAMP nucleotide second messenger 11 1.62% 0.00328727754325422 CAP1, OPRL1, OPRD1, GNAQ, ADRA2A, CCR3, NPR3, GNAI2, TSHR, ADRB2, ADCYAP1, 657 85 15360 3.0255170561375233 0.9999999693246504 0.05230836292222374 6.104592586866586 GOTERM_BP_ALL GO:0065003~macromolecular complex assembly 41 6.05% 0.001027990096038568 ACTN2, ASF1B, XPO1, SRC, WAS, NOD2, LLGL1, CREBBP, HIST3H3, APC, HSPB1, HMGB2, HMGB1, PEX14, NPM1, HMGA1, DLG4, TAF1, PML, TGM2, PPARGC1A, TP53, MIS12, SLC9A3R1, PICALM, SET, PTK2, TRAF1, NCK1, SYK, PICK1, PXN, AP2M1, CAV1, SMAD3, HCFC1, SFRS9, MAPK8IP2, ADRB2, CLTCL1, MAGI1, 657 560 15360 1.7116764514024787 0.9955007204124553 0.020569493705065667 1.9483112402915226 GOTERM_BP_ALL GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger 13 1.92% 0.0042580461666184115 CCL2, OPRL1, GNAQ, OPRD1, NPR3, CCR3, ADRA2A, CCR1, TSHR, CAP1, GNAI2, ADCYAP1, ADRB2, 657 117 15360 2.597666159309995 0.9999999998166346 0.06399488422229505 7.8386826540597365 GOTERM_BP_ALL GO:0050794~regulation of cellular process 302 44.54% 9.725596107206364E-22 HSF1, FGF8, ITCH, NOD2, POU2AF1, PTPN6, YY1, NR0B1, CASP9, STAT1, TNFRSF25, KRT18, MMP14, UPF1, CDK3, PTX3, HMGB1, POU5F1, PRKCG, ZBTB17, ADRA2A, SYK, NF2, EBI3, FOXH1, ADRBK1, POU3F3, ID2, BTK, C13orf15, GCM1, NEDD9, CD5, RGS2, VAV1, ABI1, NLGN1, USH2A, ITGB2, NRIP1, PRKCE, CTBP1, SOS1, PTPN11, LEP, CD38, ADAMTS1, RAB3B, TUBB, JUN, CTSB, F2, ITGB1BP3, KHDRBS2, SOX9, FGF1, DLG1, HOXB7, AES, CXCL1, PAX3, CD2, CAV1, TNFRSF1B, IL4, HOXA10, MMP9, TCF4, SPTA1, POU3F1, MAPK1, PROX1, REL, EDA2R, IGFBP5, RUNX3, PDE6G, BTC, NR5A1, FGFBP1, RXRG, CBX2, ELA2, ZBTB16, SLAMF1, APP, PAK7, GLI1, MOS, PRKCQ, HBEGF, CRYAB, EP300, LMO2, ADCYAP1, HMGA2, ACTN2, DLGAP2, PIM1, APLP1, CITED1, CDC2, TLX1, CADM1, KNG1, PIAS3, ACTN3, MYF6, TWIST1, STAT3, SALL1, PAX5, HOXB2, PEX14, SFRP1, HABP4, SHC1, GRN, NCOA1, YEATS4, IRF8, STAR, RYR1, TRAF1, HOXD10, HAND2, IQGAP1, SMAD7, CRX, FOXO1, POU3F2, RAC1, HDAC4, NME1, CNOT3, PLN, CEBPB, PAX2, SOX10, AKAP13, RTN4, WT1, NOS3, IKZF4, MAPK8IP2, CBL, PRKCZ, ASF1B, RAP1A, CAV3, FHL2, MEOX2, YBX1, PLG, HMGB2, HSPB1, GRK1, FOXO4, EMX2, NEK2, RYBP, CDKN3, HMGA1, CIITA, WNT2, TGM2, SATB1, PPARA, KLF1, IL12A, RGS19, ITGB3, ACPP, RGS4, LRP1, FOS, HOXD4, SP4, TRAF3, SNF1LK2, NOTCH1, ZNF238, IGFBP3, HCFC1, EYA1, PDZD3, ADRB2, TBR1, RFX1, IGF1, FURIN, FGF7, CAND2, IFI16, IKZF2, ORC2L, ERBB2, APAF1, DNM2, AXL, PRTN3, AR, GSK3B, CASP2, CCL2, CCNT1, AKT1, CDC6, REN, TFAP2B, HDAC1, STAT5A, CDH5, SMAD3, NPR1, MAPK8, EPHB2, IKZF1, CD28, RUNX1T1, FGFR1, IQGAP2, GNAQ, PTEN, POU2F1, TAL1, LHX3, MLLT10, CALR, CREBBP, IAPP, NEUROD1, PRL, DDR2, MYF5, FZD1, PPARG, HGS, GPX1, EGFR, NPM1, PAWR, DNAJC1, TAF1, SEPT4, PML, PPARGC1A, CASP3, HCLS1, SET, PIK3R1, NDN, CASP1, ABL1, TSHR, ERN1, NPPB, HOXA9, IL18, NHLH1, CAMK2A, ZEB1, ARHGEF7, CTNNB1, CXXC4, PRKCA, CCNA1, BCL2L1, CBLC, CITED2, E2F1, APC, NGFR, EN1, NFE2, MYC, BCL2L10, TIE1, MLLT1, FGD1, MEIS1, SLC9A3, TP53, MAPKAPK2, DAPK1, STARD13, MAGED1, RELA, HIVEP3, NCK1, SIX3, HAND1, NR5A2, LCK, MX1, IGFBP1, APBB1, CDC7, MAPK8IP1, COPS5, ASCL1, NCOA2, 657 4422 15360 1.596665902533823 5.1098281947262235E-18 2.554914097363112E-19 1.860491843224193E-18 GOTERM_BP_ALL GO:0050793~regulation of developmental process 31 4.57% 6.876910053609306E-7 SPTA1, EPB42, CTNNB1, GNAQ, MAPK1, NLGN1, USH2A, TWIST1, IAPP, ITGB2, NGFR, FYN, PPARG, FOXO4, LEP, FGD1, ZBTB16, ITGB1BP3, AKAP2, DLG1, CRX, STAT5A, ID2, POU3F2, NOTCH1, ASCL1, IL4, IGFBP3, RTN4, LMO2, ADRB2, 657 259 15360 2.798258140723894 0.00360661028541287 3.197408868105267E-5 0.001315534303691912 GOTERM_BP_ALL GO:0050790~regulation of catalytic activity 47 6.93% 4.0515594655986884E-7 GNA15, NOS1AP, GNAQ, PRKCA, PTEN, CCNA1, CAV3, VAV1, CASP9, STAT1, CAP1, APC, ERBB2, PDE6G, APAF1, PTPN11, GPX1, EGFR, CDKN3, SHC1, BCL2L10, CCNT1, CASP3, FGD1, TP53, ELA2, SLC9A3R1, ADRA2A, F2, CTSB, ABL1, CDC6, SYK, ERN1, RGS4, LCK, PICK1, C5AR1, CAV1, SMAD3, PSEN2, GNAI2, C13orf15, GNB2L1, IRS1, ADRB2, ADCYAP1, 657 488 15360 2.251665543828131 0.0021264257212009197 2.0273030447048868E-5 7.750543587037306E-4 GOTERM_BP_ALL GO:0050789~regulation of biological process 337 49.71% 1.4367116150111065E-28 HSF1, FGF8, ITCH, NOD2, POU2AF1, PTPN6, YY1, NR0B1, CASP9, STAT1, TNFRSF25, KRT18, SLC5A7, MMP14, UPF1, CDK3, PTX3, HMGB1, FYN, POU5F1, PRKCG, TPM3, ZBTB17, ADRA2A, SYK, NF2, EBI3, FOXH1, ADRBK1, POU3F3, ID2, BTK, C13orf15, GCM1, NEDD9, CD5, RGS2, VAV1, ABI1, NLGN1, SLC6A4, USH2A, ITGB2, NRIP1, PRKCE, CTBP1, DNMT3A, SOS1, PTPN11, LEP, CD38, ADAMTS1, RAB3B, TUBB, JUN, CTSB, F2, ITGB1BP3, KHDRBS2, SOX9, FGF1, DLG1, HOXB7, AES, CXCL1, PICK1, PAX3, CD2, CAV1, TNFRSF1B, IL4, HOXA10, TCF4, MMP9, POU3F1, SPTA1, MAPK1, PROX1, IL27RA, REL, EDA2R, IGFBP5, RUNX3, PDE6G, BTC, NR5A1, RXRG, FGFBP1, THBS1, SNCB, CBX2, HSP90AA1, ELA2, ZBTB16, AKAP2, SLAMF1, APP, GLI1, PAK7, SCG5, MOS, PRKCQ, CRYAB, HBEGF, EP300, LMO2, ADCYAP1, ACTN2, HMGA2, EPB42, DLGAP2, APLP1, PIM1, CITED1, C1QA, CDC2, TLX1, CADM1, KNG1, PIAS3, ACTN3, MYF6, TWIST1, SCN5A, STAT3, SALL1, PAX5, HOXB2, PEX14, SFRP1, HABP4, CHAT, SHC1, GRN, PRKG1, NCOA1, YEATS4, IRF8, STAR, RYR1, TRAF1, HOXD10, HAND2, IQGAP1, SMAD7, CRX, FOXO1, POU3F2, RAC1, HDAC4, NME1, CNOT3, PLN, APOH, CEBPB, PAX2, SOX10, AKAP13, RTN4, WT1, NOS3, IKZF4, MAPK8IP2, CBL, PRKCZ, ASF1B, RAP1A, CAV3, SLC8A1, FHL2, MEOX2, YBX1, PLG, HMGB2, HSPB1, SPP1, GRK1, FOXO4, EMX2, NEK2, RYBP, CDKN3, HMGA1, CIITA, WNT2, TGM2, SATB1, PPARA, KLF1, IL12A, RGS19, ITGB3, ACPP, RGS4, SNPH, LRP1, S100A1, PARK2, FOS, HOXD4, SP4, TRAF3, SNF1LK2, NOTCH1, ZNF238, IGFBP3, HCFC1, EYA1, PDZD3, ADRB2, TBR1, NOS1AP, RFX1, IGF1, FURIN, SNCAIP, FGF7, IFI16, CAND2, IKZF2, ORC2L, ERBB2, APAF1, DNM2, PRTN3, AXL, GSK3B, AR, CASP2, IL16, CCL2, CCNT1, AKT1, CDC6, REN, TFAP2B, HDAC1, SNAP25, STAT5A, CDH5, SMAD3, NPR1, MAPK8, EPHB2, IKZF1, CD28, RUNX1T1, FGFR1, IQGAP2, GNAQ, PTEN, POU2F1, TAL1, LHX3, MLLT10, CALR, CREBBP, IAPP, NEUROD1, PRL, DDR2, MYF5, FZD1, PPARG, MBL2, HGS, GPX1, EGFR, NPM1, PAWR, DNAJC1, TAF1, SEPT4, ACHE, PML, ZAP70, PPARGC1A, CASP3, HCLS1, SET, PIK3R1, NDN, CASP1, ABL1, TSHR, ERN1, NPPB, HOXA9, IL18, NHLH1, CAMK2A, ZEB1, ARHGEF7, CTNNB1, CXXC4, PRKCA, CCNA1, BCL2L1, CBLC, CITED2, CD46, E2F1, APC, NGFR, EN1, NFE2, MYC, BCL2L10, TIE1, RYR2, MLLT1, STX1A, FGD1, MEIS1, SLC9A3, TP53, MAPKAPK2, CNN1, DAPK1, STARD13, MAGED1, RELA, HIVEP3, NCK1, SIX3, HAND1, NR5A2, LCK, MX1, IGFBP1, APBB1, CDC7, MAPK8IP1, COPS5, ASCL1, CR2, NCOA2, 657 4759 15360 1.6555413870954434 7.548482825268354E-25 6.862257113880321E-26 2.74840761566586E-25 GOTERM_BP_ALL GO:0044268~multicellular organismal protein metabolic process 6 0.88% 0.0016098037801608104 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0044267~cellular protein metabolic process 204 30.09% 3.5932422970382605E-7 HSF1, PPIB, XPO1, ITCH, PTPN6, ACTL6B, OPN1LW, PORCN, CASP9, STAT1, MMP14, UPF1, CDK3, FYN, PRKCG, AURKC, PTPN7, BMX, SYK, NF2, EBI3, ADRBK1, TNIK, BTK, KSR1, MMP13, RHO, ABI1, ITGB2, PRKCE, CTBP1, CSNK2A1, PTPN11, ERBB3, PTPRT, ADAMTS1, MAPK10, TUBB, F2, CTSB, JUN, PTPRZ1, TXK, PICK1, IL4, MMP12, MMP9, SPTA1, GNA15, MAPK1, REL, ROR2, CRKL, HSP90AA1, ELA2, EPHB1, ZBTB16, PAK7, MOS, GUCY2C, SCG5, MMP8, PRKCQ, CRYAB, EP300, ACP1, EPB42, SIAH2, PIM1, TRPC4, APLP1, CDC2, C1QA, LIPE, WAS, HK3, PIAS3, MMP7, PRKAR2A, FGR, PCSK1, NTRK1, BLK, PTPRN, PRKG1, CTSG, MMP1, HCK, MIS12, RYR1, MAP3K8, RAC1, CEBPB, HSPA8, MAPK8IP2, CBL, MYLK, PRKCZ, DYRK1A, EPHA7, SRC, PLG, PTPRO, HSPB1, TEK, PCSK2, GRK1, NEK2, CDKN3, HMGA1, ALK, WNT2, TGM2, SATB1, PTK2, TTN, IL12A, UBE2I, PXN, PARK2, SNF1LK2, CAMK4, IGFBP3, GZMA, PRKACA, ADRB2, PTPRH, CASK, FURIN, CAND2, ERBB2, AXL, PRTN3, GSK3B, MAPK14, CASP2, CCL2, CCNT1, AKT1, REN, HDAC1, TUBA1A, STAT5A, TUBA8, SMAD3, NPR1, TGM1, PSEN2, MAPK8, EPHB2, CD28, FGFR1, GNAQ, PTEN, CALR, CREBBP, DDR2, PTPN21, MBL2, EGFR, TAF1, DNAJC1, ZAP70, PML, ACHE, CASP3, PPARGC1A, ROS1, HCLS1, SET, PIK3R1, CASP1, ABL1, ERN1, LRP2, MME, IL18, CAMK2A, NEDD4, FES, PRKCA, CBLC, TEC, PSMB9, CD46, PAK1, APC, STAMBPL1, PPP1CA, STX12, TIE1, TP53, MAPKAPK2, DAPK1, RELA, KBTBD10, NCK1, CSF1R, LCK, APBB1, CDC7, NID1, COPS5, CR2, 657 3482 15360 1.3697056486195147 0.0018861088989369224 1.8328859617056104E-5 6.873795842854413E-4 GOTERM_BP_ALL GO:0044266~multicellular organismal macromolecule catabolic process 6 0.88% 0.0016098037801608104 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0007173~epidermal growth factor receptor signaling pathway 8 1.18% 2.691338926904946E-4 PDE6G, CBLC, SHC3, EGFR, HBEGF, ERBB2IP, SHC1, CBL, 657 31 15360 6.0332891442038585 0.756884779108223 0.006378753383622815 0.5135949330074108 GOTERM_BP_ALL GO:0050776~regulation of immune response 12 1.77% 0.00329550366337962 LCK, C1QA, FYN, MBL2, SMAD3, NOD2, IL4, CR2, CD46, IL12A, IL27RA, SYK, 657 99 15360 2.8338176283381764 0.9999999706263907 0.05227795606199248 6.119416007930978 GOTERM_BP_ALL GO:0007172~signal complex assembly 6 0.88% 5.21629967687484E-5 PICK1, PXN, SRC, PTK2, NCK1, MAPK8IP2, 657 11 15360 12.752179327521793 0.23972231184236004 0.0015130615326394148 0.09973985420679288 GOTERM_BP_ALL GO:0009581~detection of external stimulus 8 1.18% 0.0040227856747268404 TRPC3, PDC, NGFR, RHO, GRK1, NOD2, OPN1LW, SAG, 657 48 15360 3.896499238964992 0.9999999993656007 0.060735181877707656 7.42124385423526 GOTERM_BP_ALL GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway 46 6.78% 3.529188174097436E-21 FGFR1, LCP2, PRKCA, PTEN, IGF1, EPHA7, RGS2, SRC, CBLC, ABI1, DDR2, ERBB2, PDE6G, TEK, COL1A2, PTPN11, FOXO4, EGFR, HMGA1, SHC1, ERBB3, NTRK1, PTPRT, ALK, ROS1, EPHB1, SHC3, PTK2, PIK3R1, NDN, AKT1, NCK1, ERBB2IP, CSF1R, FOXO1, PICK1, PXN, SNF1LK2, FRS3, CRYAB, HBEGF, EPHB2, MAPK8IP2, IRS1, CBL, ADRB2, 657 194 15360 5.543473144094524 1.854235466670793E-17 8.428343030321786E-19 6.751283662958555E-18 GOTERM_BP_ALL GO:0044260~cellular macromolecule metabolic process 205 30.24% 6.849269427651025E-7 HSF1, PPIB, XPO1, ITCH, PTPN6, ACTL6B, OPN1LW, PORCN, CASP9, STAT1, MMP14, UPF1, CDK3, PPP1R3A, FYN, PRKCG, AURKC, PTPN7, BMX, SYK, NF2, EBI3, ADRBK1, TNIK, BTK, KSR1, MMP13, RHO, ABI1, ITGB2, PRKCE, CTBP1, CSNK2A1, PTPN11, ERBB3, PTPRT, ADAMTS1, MAPK10, TUBB, CTSB, JUN, F2, PTPRZ1, TXK, PICK1, IL4, MMP12, MMP9, SPTA1, GNA15, MAPK1, REL, ROR2, CRKL, HSP90AA1, ELA2, EPHB1, ZBTB16, PAK7, MOS, GUCY2C, SCG5, MMP8, PRKCQ, CRYAB, EP300, ACP1, EPB42, SIAH2, PIM1, TRPC4, APLP1, CDC2, C1QA, LIPE, WAS, HK3, PIAS3, MMP7, PRKAR2A, FGR, PCSK1, NTRK1, BLK, PTPRN, PRKG1, CTSG, MMP1, HCK, MIS12, RYR1, MAP3K8, RAC1, CEBPB, HSPA8, MAPK8IP2, CBL, MYLK, PRKCZ, DYRK1A, EPHA7, SRC, PLG, PTPRO, HSPB1, TEK, PCSK2, GRK1, NEK2, CDKN3, HMGA1, ALK, WNT2, TGM2, SATB1, PTK2, TTN, IL12A, UBE2I, PXN, PARK2, SNF1LK2, CAMK4, IGFBP3, GZMA, PRKACA, ADRB2, PTPRH, CASK, FURIN, CAND2, ERBB2, AXL, PRTN3, GSK3B, MAPK14, CASP2, CCL2, CCNT1, AKT1, REN, HDAC1, TUBA1A, STAT5A, TUBA8, SMAD3, NPR1, TGM1, PSEN2, MAPK8, EPHB2, CD28, FGFR1, GNAQ, PTEN, CALR, CREBBP, DDR2, PTPN21, MBL2, EGFR, TAF1, DNAJC1, ZAP70, PML, ACHE, CASP3, PPARGC1A, ROS1, HCLS1, SET, PIK3R1, CASP1, ABL1, ERN1, LRP2, MME, IL18, CAMK2A, NEDD4, FES, PRKCA, CBLC, TEC, CD46, PSMB9, PAK1, APC, STAMBPL1, PPP1CA, STX12, TIE1, TP53, MAPKAPK2, DAPK1, KBTBD10, RELA, NCK1, CSF1R, LCK, APBB1, CDC7, NID1, COPS5, CR2, 657 3534 15360 1.3561669677212622 0.003592140161856383 3.212990694345663E-5 0.0013102467594006129 GOTERM_BP_ALL GO:0007167~enzyme linked receptor protein signaling pathway 54 7.96% 4.6908959238319284E-20 FGFR1, PTEN, EPHA7, SRC, PDE6G, DDR2, COL1A2, TEK, FOXO4, EGFR, HMGA1, ALK, ROS1, SHC3, EPHB1, NDN, PIK3R1, PTK2, ERBB2IP, SYK, FOXH1, PXN, GUCY2C, FRS3, SNF1LK2, HBEGF, CRYAB, ADRB2, PDZD3, LCP2, PRKCA, AKAP3, IGF1, RGS2, CBLC, ABI1, CITED2, ERBB2, PTPN11, ERBB3, SHC1, PTPRT, NTRK1, AKT1, NCK1, CSF1R, SMAD7, FOXO1, PICK1, SMAD3, EPHB2, MAPK8IP2, IRS1, CBL, 657 285 15360 4.429704397981254 2.464596718381295E-16 9.479218147620366E-18 8.973613038727988E-17 GOTERM_BP_ALL GO:0044259~multicellular organismal macromolecule metabolic process 6 0.88% 0.0016098037801608104 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0007166~cell surface receptor linked signal transduction 143 21.09% 1.911936248321747E-12 CXCL2, DARC, EPHA7, SRC, PTPN6, OPN1LW, PORCN, CAP1, CD247, TNFRSF25, PDC, TEK, COL1A2, FYN, WNT1, GRK1, FOXO4, HMGA1, ALK, WNT2, TGM2, NTSR1, SLC9A3R1, PTK2, NPR3, ADRA2A, RGS19, SYK, ITGB3, RGS4, FOXH1, ADRBK1, LRP1, PXN, SNF1LK2, FRS3, NOTCH1, GNAI2, GNB2L1, WNT4, HOMER1, PDZD3, ADRB2, NEDD9, UCN, AKAP3, IGF1, RHO, RGS2, VAV1, ABI1, DVL1, ITGB2, ERBB2, CSNK2A1, PTPN11, PNOC, MAPK14, GSK3B, ERBB3, PTPRT, CCL2, ADAMTS1, AGTR2, AKT1, AES, CXCL1, STAT5A, PICK1, CD2, SMAD3, TNFRSF1B, NPR1, PSEN2, EPHB2, CD28, GNA15, FGFR1, OPRD1, GNAQ, PTEN, MAPK1, IL27RA, PRL, DDR2, PDE6G, FZD1, ROR2, EGFR, BAI2, CXCL3, ROS1, SHC3, EPHB1, PIK3R1, NDN, CCR1, IL8RA, KLRA1, ERBB2IP, TSHR, NPPB, APP, GLI1, GUCY2C, SCG5, CCR4, HBEGF, CRYAB, SAG, MAGI1, ADCYAP1, CTNNB1, VIPR2, LCP2, CXXC4, PRKCA, CNTN1, CBLC, CITED2, CCR3, CEACAM1, STAT3, APC, SFRP1, SHC1, NTRK1, OPRL1, RELA, NCK1, ITGB1, SIX3, CSF1R, SMAD7, LCK, FOXO1, C5AR1, ASCL1, NOS3, GNG13, MAPK8IP2, IRS1, CBL, 657 1868 15360 1.7897196718586528 1.0045201781494484E-8 2.283000455349793E-10 3.6574632211738844E-9 GOTERM_BP_ALL GO:0007165~signal transduction 296 43.66% 5.246189077448278E-32 CXCL2, DARC, FGF8, NOD2, PTPN6, OPN1LW, PORCN, ANGPT4, CASP9, PLCD1, STAT1, CAP1, TNFRSF25, HMGB1, COL1A2, FYN, PRKCG, MAPKBP1, NTSR1, SLC9A3R1, ADRA2A, ARRB2, BMX, ACCN3, SYK, CA8, NF2, FOXH1, ADRBK1, IL4R, TNIK, BTK, FRS3, NTS, GNB2L1, KSR1, WNT4, NEDD9, MS4A3, RHO, RGS2, VAV1, ABI1, DVL1, NRIP1, ITGB2, PRKCE, CSNK2A1, SOS1, PTPN11, NDC80, CRHBP, ERBB3, RASIP1, PTPRT, LEP, CD38, FCGR2B, ADAMTS1, AGTR2, MAPK10, IRS4, RAB3B, F2, FGF1, TXK, AES, CXCL1, PICK1, CD2, CAV1, TNFRSF1B, MLLT4, IL4, GNA15, ASIP, MAPK1, INPPL1, IL27RA, REL, EDA2R, IGFBP5, GUCY1B3, PDE6G, SH2D1A, ROR2, NR5A1, CRKL, FGFBP1, HSP90AA1, SHC3, EPHB1, CCR1, SH3BP1, APP, GLI1, GUCY2C, SCG5, CCR4, TRH, PRKCQ, HBEGF, CRYAB, EP300, MAGI1, ADCYAP1, VIPR2, SIAH2, LCP2, CCL7, PRKAR2A, FGR, STAT3, SFRP1, SHC1, FGF13, BLK, NTRK1, GRN, PRKG1, NCOA1, OPRL1, HCK, COPS2, RYR1, TRAF1, PSTPIP1, IQGAP1, SMAD7, FOXO1, RAC1, AKAP13, NOS3, GNG13, AKAP5, MAPK8IP2, CBL, PRKCZ, RAP1A, CAV3, EPHA7, SRC, FHL2, GRAP, CD247, PDC, HMGB2, TEK, WNT1, GRK1, FOXO4, HMGA1, YWHAE, DLG4, ALK, CCL8, WNT2, TGM2, PPFIA1, PTK2, NPR3, IL12A, RGS19, ELMO1, ITGB3, RGS4, LRP1, S100A1, PXN, TRAF3, SNF1LK2, NOTCH1, GNAI2, CAMK4, GZMA, IGFBP3, HOMER1, PDZD3, ADRB2, UCN, IL18R1, ZYX, PPP2R5A, AKAP3, IGF1, FGF7, ANGPT1, CD244, GRAP2, DOK3, ERBB2, APAF1, DNM2, PNOC, AXL, MAPK14, AR, GSK3B, CASP2, CCL2, TYROBP, AKT1, REN, STAT5A, SMAD3, MPP3, NPR1, PSEN2, MAPK8, EPHB2, CD28, FGFR1, OPRD1, IQGAP2, GNAQ, PTEN, TG, CREBBP, IAPP, PRL, DDR2, FZD1, PPARG, HGS, GPX1, EGFR, NPM1, BAI2, CXCL3, ZAP70, GUCY1A2, PPARGC1A, CASP3, HCLS1, ROS1, PIK3R1, NDN, CASP1, DCX, ABL1, IL8RA, KLRA1, ERBB2IP, TSHR, SH2D3C, CSPG4, ERN1, NPPB, INPP5D, SAG, ARHGEF7, FES, CTNNB1, CXXC4, PRKCA, BCL2L1, CNTN1, TEC, CBLC, CITED2, CCR3, CEACAM1, SHC2, SLA, PAK1, ITPR1, APC, NGFR, CCL5, BCL2L10, TIE1, RYR2, FGD1, TP53, MAPKAPK2, SH3GL2, DAPK1, STARD13, RELA, NCK1, ITGB1, SIX3, CSF1R, ROPN1B, LCK, MX1, IGFBP1, CNTNAP1, APBB1, PLCG1, C5AR1, MAPK8IP1, RAB27A, ASCL1, IRS1, NCOA2, 657 3758 15360 1.8414536052160262 2.7563477412913253E-28 4.593912902152208E-29 1.0035880452995734E-28 GOTERM_BP_ALL GO:0044256~protein digestion 6 0.88% 0.0016098037801608104 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0044254~multicellular organismal protein catabolic process 6 0.88% 0.0016098037801608104 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0007160~cell-matrix adhesion 14 2.06% 9.861217346875066E-5 ACTN2, PTEN, PPFIA1, ITGB1, ACTN3, NF2, ITGB3, ITGB2, MMP14, PXN, MYF5, SPP1, NID1, CD44, 657 89 15360 3.6775947873377453 0.404368985590405 0.0026535700012617625 0.1884750623047382 GOTERM_BP_ALL GO:0044243~multicellular organismal catabolic process 6 0.88% 0.0020109110481224633 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 22 15360 6.376089663760896 0.9999744778505163 0.034752869493891336 3.777517980199796 GOTERM_BP_ALL GO:0007155~cell adhesion 76 11.21% 1.8587918897659348E-11 DSC1, DSG3, PKP3, DSC3, PTEN, INPPL1, DDR2, MMP14, MYF5, NPHS1, SPP1, ROR2, LY9, EGFR, THBS1, ACHE, TGM2, PPFIA1, CCR1, ABL1, ERBB2IP, TTN, IL12A, SYK, ITGB3, NF2, APP, PXN, MYBPC1, IL18, KIRREL, CD44, ICAM5, NEDD9, MAGI1, HSPG2, ACTN2, ZYX, CTNNB1, APLP1, CNTN1, CASK, VAV1, KNG1, CADM1, NLGN1, CCR3, USH2A, CEACAM1, ACTN3, ITGB2, APC, APAF1, CCL5, CLSTN3, PKP2, NFASC, CCL2, CD84, ITGB1, PSTPIP1, SOX9, DLG1, ROPN1B, THBS2, CNTNAP1, STAT5A, CD2, DSG2, CD72, SELE, CDH5, RAC1, NID1, MLLT4, F11R, 657 774 15360 2.295611954739065 9.766086905838023E-8 1.8426580261632353E-9 3.555838956614821E-8 GOTERM_BP_ALL GO:0007154~cell communication 329 48.53% 2.3155788313153405E-38 CXCL2, DARC, FGF8, NOD2, HAP1, PTPN6, OPN1LW, PORCN, ANGPT4, CASP9, PLCD1, STAT1, CAP1, TNFRSF25, SLC5A7, HMGB1, COL1A2, FYN, PRKCG, MAPKBP1, NTSR1, SLC9A3R1, ADRA2A, ARRB2, BMX, SYK, ACCN3, CA8, NF2, FOXH1, ADRBK1, IL4R, TNIK, BTK, FRS3, NTS, GNB2L1, KSR1, WNT4, NEDD9, MS4A3, RHO, RGS2, VAV1, ABI1, NLGN1, SLC6A4, DVL1, NRIP1, ITGB2, PRKCE, CSNK2A1, SOS1, PTPN11, NDC80, CRHBP, ERBB3, RASIP1, PTPRT, LEP, CD38, FCGR2B, ADAMTS1, AGTR2, MAPK10, IRS4, RAB3B, F2, FGF1, TXK, AES, CXCL1, PICK1, CD2, CAV1, ACCN1, TNFRSF1B, MLLT4, IL4, SLC8A2, POU3F1, GNA15, ASIP, MAPK1, INPPL1, IL27RA, REL, EDA2R, IGFBP5, GUCY1B3, PDE6G, SH2D1A, ROR2, NR5A1, CRKL, GJA3, FGFBP1, SNCB, HSP90AA1, EPHB1, SHC3, CCR1, SH3BP1, APP, GLI1, CCR4, SCG5, GUCY2C, PRKCQ, TRH, CRYAB, HBEGF, EP300, AREG, ADCYAP1, MAGI1, SIAH2, VIPR2, LCP2, DLGAP2, CCL7, C1QA, PRKAR2A, FGR, STAT3, PCSK1, SALL1, SFRP1, CHAT, SHC1, FGF13, BLK, NTRK1, GRN, PRKG1, NCOA1, OPRL1, HCK, COPS2, RYR1, TRAF1, PSTPIP1, IQGAP1, SMAD7, FOXO1, RAC1, AKAP13, NOS3, GNG13, AKAP5, MAPK8IP2, CBL, PRKCZ, RAP1A, CAV3, EPHA7, SRC, NOS1, SLC8A1, FHL2, GRAP, CD247, PDC, HMGB2, TEK, PCSK2, WNT1, GRK1, FOXO4, KCNK3, HMGA1, YWHAE, DLG4, ALK, CCL8, WNT2, TGM2, PPFIA1, PTK2, NPR3, BSN, IL12A, RGS19, ELMO1, ITGB3, RGS4, SNPH, LRP1, S100A1, PARK2, PXN, TRAF3, SNF1LK2, NOTCH1, GNAI2, CAMK4, GZMA, IGFBP3, HOMER1, PDZD3, ADRB2, UCN, IL18R1, PPP2R5A, ZYX, NOS1AP, AKAP3, IGF1, FURIN, SNCAIP, FGF7, ANGPT1, PLP1, CD244, GRAP2, DOK3, ERBB2, APAF1, DNM2, AXL, PNOC, MAPK14, GSK3B, AR, CASP2, CCL2, TYROBP, AKT1, REN, SNAP25, STAT5A, SMAD3, MPP3, NPR1, PSEN2, MAPK8, EPHB2, CD28, FGFR1, OPRD1, IQGAP2, GNAQ, PTEN, TG, CREBBP, IAPP, PRL, DDR2, FZD1, PPARG, HGS, GPX1, EGFR, NPM1, BAI2, CXCL3, ACHE, ZAP70, GUCY1A2, PPARGC1A, CASP3, HCLS1, ROS1, PIK3R1, NDN, CASP1, DCX, ABL1, IL8RA, KLRA1, ERBB2IP, TSHR, SH2D3C, CSPG4, ERN1, NPPB, INPP5D, MME, IL18, SAG, ARHGEF7, FES, CTNNB1, CXXC4, PRKCA, BCL2L1, CNTN1, TEC, CBLC, CITED2, CCR3, CEACAM1, SHC2, SLA, PAK1, ITPR1, APC, NGFR, CCL5, BCL2L10, TIE1, RYR2, STX1A, FGD1, TP53, MAPKAPK2, SH3GL2, DAPK1, STARD13, RELA, PPFIA4, NCK1, ITGB1, KIF5A, SIX3, CSF1R, ROPN1B, LCK, MX1, IGFBP1, CNTNAP1, APBB1, PLCG1, C5AR1, MAPK8IP1, RAB27A, ASCL1, IRS1, NCOA2, 657 4123 15360 1.8655565116946144 1.2166051179730798E-34 6.083025589865399E-35 4.4296673237464813E-35 GOTERM_BP_ALL GO:0044236~multicellular organismal metabolic process 7 1.03% 5.234774166995019E-4 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, ADRB2, 657 25 15360 6.546118721461187 0.936140535151862 0.011638426259414136 0.9966666164790028 GOTERM_BP_ALL GO:0050730~regulation of peptidyl-tyrosine phosphorylation 9 1.33% 2.0142140838478738E-4 PRKCE, PRKCA, HCLS1, EGFR, IL4, IL12A, SYK, NF2, ITGB2, 657 39 15360 5.395152792413066 0.6529806277870924 0.004887897902172478 0.38461338285790125 GOTERM_BP_ALL GO:0043687~post-translational protein modification 138 20.35% 4.503780734942613E-18 PRKCZ, DYRK1A, EPHA7, SRC, ITCH, PTPN6, OPN1LW, STAT1, MMP14, PTPRO, CDK3, TEK, FYN, PCSK2, GRK1, NEK2, CDKN3, PRKCG, ALK, WNT2, TGM2, AURKC, SATB1, PTK2, PTPN7, TTN, BMX, IL12A, SYK, NF2, ADRBK1, UBE2I, PARK2, TNIK, BTK, SNF1LK2, CAMK4, IGFBP3, PRKACA, KSR1, PTPRH, CASK, RHO, FURIN, ABI1, CAND2, ITGB2, PRKCE, CTBP1, ERBB2, CSNK2A1, PTPN11, AXL, MAPK14, GSK3B, ERBB3, PTPRT, CCL2, MAPK10, CCNT1, JUN, F2, AKT1, HDAC1, PTPRZ1, TXK, PICK1, TGM1, NPR1, PSEN2, IL4, MAPK8, EPHB2, GNA15, FGFR1, GNAQ, PTEN, MAPK1, CREBBP, DDR2, PTPN21, ROR2, EGFR, CRKL, TAF1, PML, ZAP70, PPARGC1A, HCLS1, ROS1, SET, EPHB1, PIK3R1, ZBTB16, ABL1, ERN1, PAK7, MOS, GUCY2C, SCG5, PRKCQ, CAMK2A, EP300, NEDD4, ACP1, FES, EPB42, SIAH2, PIM1, PRKCA, CDC2, TEC, LIPE, CBLC, PIAS3, PRKAR2A, PAK1, FGR, STAMBPL1, PPP1CA, BLK, NTRK1, PTPRN, PRKG1, TIE1, HCK, TP53, MAPKAPK2, RYR1, DAPK1, KBTBD10, CSF1R, LCK, MAP3K8, CDC7, NID1, CBL, MYLK, 657 1522 15360 2.119777509765449 2.366286398138849E-14 7.170564842844997E-16 8.615664509059997E-15 GOTERM_BP_ALL GO:0009416~response to light stimulus 11 1.62% 0.0019011698241182193 TRPC3, PDC, RHO, ELA2, GRK1, GPX1, RELA, OPN1LW, MAPK8, SAG, IL12A, 657 79 15360 3.2553031616669554 0.9999545207081226 0.03321377985227936 3.574906026989866 GOTERM_BP_ALL GO:0021700~developmental maturation 18 2.65% 8.040122741381344E-9 EPB42, CTNNB1, FGFR1, ACTA1, GNAQ, NLGN1, AKT1, PLP1, KLF1, TTN, REN, ACTB, APP, PICK1, CDH5, MYOZ1, PSEN2, SOX10, 657 73 15360 5.7646838055920435 4.2241913092544436E-5 5.867054571062624E-7 1.5380632312211873E-5 GOTERM_BP_ALL GO:0040018~positive regulation of multicellular organism growth 5 0.74% 0.0030867255251772266 STAT5A, POU3F2, AKT1, TSHR, DLG1, 657 15 15360 7.792998477929984 0.9999999117186763 0.049341548474610364 5.742511983752008 GOTERM_BP_ALL GO:0040014~regulation of multicellular organism growth 7 1.03% 0.0014634983114827829 APP, STAT5A, POU3F2, AKT1, TSHR, DLG1, ADRB2, 657 30 15360 5.455098934550989 0.9995448357451833 0.027593430641476457 2.762817147822494 GOTERM_BP_ALL GO:0060047~heart contraction 11 1.62% 4.9264432571728133E-5 SCN5A, ADRBK1, S100A1, RYR2, PRKCA, SP4, PLN, GPX1, HBEGF, SLC8A1, ADRB2, 657 51 15360 5.042528426895872 0.22805479127396922 0.0014531100915911033 0.0942000406379595 GOTERM_BP_ALL GO:0040008~regulation of growth 22 3.24% 1.5368640398486834E-4 YEATS4, PML, TP53, ITCH, NDN, AKT1, TSHR, DLG1, NPPB, APP, IGFBP5, IGFBP1, STAT5A, APBB1, POU3F2, SMAD3, PRKCQ, NPR1, IGFBP3, SHC1, ADRB2, NEDD9, 657 202 15360 2.546227225462272 0.5540419641223189 0.0038563271192993964 0.29359054091127046 GOTERM_BP_ALL GO:0040007~growth 28 4.13% 1.3267406921308724E-4 FGFR1, ITCH, FHL1, IGFBP5, PLG, AR, SHC1, PML, YEATS4, TP53, NDN, AKT1, TSHR, ERBB2IP, DLG1, NPPB, APP, IGFBP1, STAT5A, APBB1, POU3F2, SMAD3, PRKCQ, NPR1, PSEN2, IGFBP3, NEDD9, ADRB2, 657 291 15360 2.2495253338354595 0.5019803800600433 0.0033947895312577137 0.2534984767794235 GOTERM_BP_ALL GO:0043623~cellular protein complex assembly 10 1.47% 9.403718448731987E-4 PICK1, PXN, XPO1, MIS12, SMAD3, SRC, PTK2, NCK1, MAPK8IP2, ADRB2, 657 60 15360 3.896499238964992 0.9928671056295145 0.018976694413534334 1.783664472549995 GOTERM_BP_ALL GO:0009314~response to radiation 12 1.77% 0.0035639674214419706 TRPC3, PML, PDC, RHO, ELA2, GRK1, GPX1, RELA, OPN1LW, MAPK8, SAG, IL12A, 657 100 15360 2.805479452054794 0.999999992866987 0.055917298900479806 6.6019706658507875 GOTERM_BP_ALL GO:0050678~regulation of epithelial cell proliferation 10 1.47% 1.4934880268622296E-5 PRL, RUNX3, ERBB2, SMAD3, NME1, EGFR, GPX1, NOTCH1, MAGED1, GRN, 657 36 15360 6.494165398274987 0.07546876869407271 5.195235895439909E-4 0.02856633273269349 GOTERM_BP_ALL GO:0050673~epithelial cell proliferation 10 1.47% 3.722434457584621E-5 PRL, RUNX3, ERBB2, SMAD3, NME1, EGFR, GPX1, NOTCH1, MAGED1, GRN, 657 40 15360 5.844748858447488 0.17764273270013176 0.0011430908902603232 0.07118558526982843 GOTERM_BP_ALL GO:0050671~positive regulation of lymphocyte proliferation 9 1.33% 7.178012379703285E-5 CD28, EBI3, STAT5A, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 34 15360 6.1885576148267525 0.31418427267180293 0.002036552091140287 0.1372249812224724 GOTERM_BP_ALL GO:0050670~regulation of lymphocyte proliferation 11 1.62% 2.3290950348140595E-5 CD28, EBI3, STAT5A, ERBB2, CASP3, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 47 15360 5.471679782376372 0.11518091465958602 7.791363041933508E-4 0.04454583044102289 GOTERM_BP_ALL GO:0000278~mitotic cell cycle 26 3.83% 0.0025085521260684064 CD28, INCENP, CCNA1, CDC2, E2F1, CDK3, FOXO4, DNM2, NEK2, CDKN3, NDC80, SHC1, TAF1, PML, YEATS4, MIS12, TP53, CDC6, ABL1, TTN, DLG1, UBE2I, STAT5A, APBB1, CDC7, NEDD9, 657 318 15360 1.9114901926998076 0.9999981428952021 0.04102821413239799 4.691245265231059 GOTERM_BP_ALL GO:0035295~tube development 18 2.65% 1.800944846329868E-4 CTNNB1, FGFR1, AGTR2, WNT2, KNG1, FGF1, NPPB, FOXH1, MMP14, GLI1, APAF1, CAV1, NOTCH1, NPR1, NTS, EP300, CD44, ADRB2, 657 147 15360 2.86273413474979 0.6118260195625802 0.00441220774946427 0.34395616597815426 GOTERM_BP_ALL GO:0000270~peptidoglycan metabolic process 7 1.03% 9.98467353878217E-4 MMP13, MMP1, MMP14, MMP8, MMP7, MMP12, MMP9, 657 28 15360 5.844748858447488 0.9947449626939429 0.02006079209383349 1.8928631820174235 GOTERM_BP_ALL GO:0043549~regulation of kinase activity 26 3.83% 2.732843846403054E-5 CCNA1, PTEN, PRKCA, CAV3, APC, PDE6G, ERBB2, PTPN11, EGFR, CDKN3, SHC1, CASP3, CCNT1, ELA2, ADRA2A, CDC6, SYK, RGS4, ERN1, PICK1, CAV1, C5AR1, C13orf15, GNB2L1, IRS1, ADRB2, 657 236 15360 2.5756520393158424 0.13375333436782788 8.859380513849269E-4 0.05226594090063097 GOTERM_BP_ALL GO:0055082~cellular chemical homeostasis 27 3.98% 1.5431583899618612E-6 GNA15, TRPC6, CCL7, BCL2L1, PRKCA, CAV3, KNG1, CCR3, CALR, KCNA5, CCL5, GRK1, MYC, CCL2, RYR2, OPRL1, TGM2, SLC9A3R1, ELA2, RYR1, CCR1, LCK, APP, CNTNAP1, C5AR1, CCR4, PLN, 657 214 15360 2.949686339777237 0.008074981195551723 6.538302724823364E-5 0.002951997393529915 GOTERM_BP_ALL GO:0055080~cation homeostasis 22 3.24% 3.380610962182329E-5 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, APP, CNTNAP1, C5AR1, CCR4, CCL5, PLN, MYC, 657 182 15360 2.8260324150735108 0.16273973105542483 0.0010567049977868725 0.0646507625482351 GOTERM_BP_ALL GO:0007049~cell cycle 74 10.91% 6.160850858194932E-8 CD28, RAP1A, INCENP, PTEN, FGF8, MAPK1, CALR, STAT1, RUNX3, KRT18, UPF1, CDK3, FOXO4, EGFR, NEK2, NPM1, CDKN3, TAF1, SEPT4, PML, CASP3, AURKC, ZBTB17, NDN, ABL1, ERBB2IP, TTN, ACPP, NF2, ERN1, UBE2I, MOS, C13orf15, HCFC1, EP300, NEDD9, ADCYAP1, SIAH2, PRKCA, CCNA1, CDC2, RGS2, CADM1, CITED2, FGF7, E2F1, APC, PPP1CA, RPA1, PTPN11, DNM2, AXL, NDC80, SHC1, MYC, YEATS4, CCNT1, TP53, MIS12, RYR1, F2, STARD13, CDC6, FGF1, DLG1, LCK, STAT5A, APBB1, CDC7, HDAC4, NME1, COPS5, WT1, EPHB2, 657 894 15360 1.9351741186806002 3.236387319860423E-4 3.636972198628463E-6 1.178560804948603E-4 GOTERM_BP_ALL GO:0055074~calcium ion homeostasis 20 2.95% 8.566054754646166E-7 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, CNTNAP1, C5AR1, CCR4, CCL5, PLN, 657 121 15360 3.864296765915695 0.004490494540043577 3.8140010749532216E-5 0.0016386606097706924 GOTERM_BP_ALL GO:0031589~cell-substrate adhesion 14 2.06% 1.5570479984606788E-4 ACTN2, PTEN, PPFIA1, ITGB1, ACTN3, NF2, ITGB3, ITGB2, MMP14, PXN, MYF5, SPP1, NID1, CD44, 657 93 15360 3.5194186674522507 0.5587469303084864 0.0038883099837355717 0.2974408869969136 GOTERM_BP_ALL GO:0055066~di-, tri-valent inorganic cation homeostasis 22 3.24% 5.06417471304534E-6 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, APP, CNTNAP1, C5AR1, CCR4, CCL5, PLN, MYC, 657 161 15360 3.1946453387787517 0.026256387308680185 1.8735738524444656E-4 0.009687245009737389 GOTERM_BP_ALL GO:0055065~metal ion homeostasis 20 2.95% 2.604914511679369E-6 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, CNTNAP1, C5AR1, CCR4, CCL5, PLN, 657 130 15360 3.5967685282753776 0.013593007916258726 1.0213089376243101E-4 0.004983044441930762 GOTERM_BP_ALL GO:0035264~multicellular organism growth 7 1.03% 0.0024488638004373925 APP, STAT5A, POU3F2, AKT1, TSHR, DLG1, ADRB2, 657 33 15360 4.9591808495918075 0.9999974568577106 0.040448042581666566 4.582086115929118 GOTERM_BP_ALL GO:0000165~MAPKKK cascade 26 3.83% 2.6516121946810576E-8 FGFR1, MAPK1, PRKCA, CAV3, PAK1, EDA2R, PDE6G, ROR2, PTPN11, SHC1, CRKL, FGF13, MAPK10, MAPKAPK2, ADRA2A, REN, SYK, SH2D3C, RGS4, TNIK, CAV1, C5AR1, MAPK8IP1, MAPK8, MAPK8IP2, ADRB2, 657 163 15360 3.7291649158192564 1.393060026677606E-4 1.786097208134052E-6 5.072492855751065E-5 GOTERM_BP_ALL GO:0035239~tube morphogenesis 14 2.06% 6.884521461153083E-4 CTNNB1, FGFR1, AGTR2, WNT2, KNG1, NPPB, MMP14, APAF1, CAV1, NOTCH1, NPR1, NTS, CD44, ADRB2, 657 108 15360 3.030610519194994 0.973173719521162 0.014484293327557518 1.3088116945232153 GOTERM_BP_ALL GO:0000122~negative regulation of transcription from RNA polymerase II promoter 20 2.95% 2.1563343008388572E-5 CBX2, CTNNB1, IRF8, HAND1, TWIST1, NRIP1, STAT3, ORC2L, E2F1, ID2, HMGB1, PPARG, SMAD3, HDAC4, RYBP, ZNF238, ZEB1, PAWR, TCF4, NCOA2, 657 150 15360 3.1171993911719937 0.10711280339891749 7.354114372951637E-4 0.04124228720970846 GOTERM_BP_ALL GO:0048878~chemical homeostasis 34 5.01% 8.248738841109306E-8 TRPC6, GNA15, CCL7, PRKCA, BCL2L1, CAV3, KNG1, CCR3, CALR, KCNA5, CCL5, GRK1, SLC2A4, MYC, CCL2, RYR2, OPRL1, TGM2, PPARGC1A, SLC9A3, ELA2, SLC9A3R1, RYR1, CCR1, NR5A2, NPPB, LCK, APP, CNTNAP1, C5AR1, CAV1, CCR4, NPR1, PLN, 657 275 15360 2.8904939809049397 4.332948569987227E-4 4.762502465172069E-6 1.5779700984763778E-4 GOTERM_BP_ALL GO:0007010~cytoskeleton organization and biogenesis 49 7.23% 5.784494418307491E-7 PRKCZ, SPTA1, KIF17, LLGL1, HAP1, CALR, FHL3, CAP1, FHOD1, BFSP2, MYOZ1, WNT2, EPB41L3, ADRA2A, PPP1R9A, ABL1, TTN, ERBB2IP, VIM, NF2, ELMO1, NEDD9, WAS, NLGN1, KISS1, PAK1, APC, FMNL1, MYH4, SYNPO, NDC80, EHD2, PRKG1, ACTA1, FGD1, CNN1, TUBB, NCK1, KIF5A, TUBA1A, DLG1, ACTB, SHANK1, CXCL1, TUBA8, APBB1, SGCG, RAC1, CBL, 657 526 15360 2.1778912096116114 0.0030345606311654727 2.7628475110064166E-5 0.0011065592413705971 GOTERM_BP_ALL GO:0019935~cyclic-nucleotide-mediated signaling 15 2.21% 8.998409113430409E-4 CCL2, OPRL1, OPRD1, GNAQ, TGM2, NPR3, CCR3, ADRA2A, CCR1, TSHR, CAP1, GNAI2, ADCYAP1, ADRB2, PDZD3, 657 125 15360 2.805479452054794 0.9911725804423551 0.018306505176243992 1.707412657459484 GOTERM_BP_ALL GO:0048869~cellular developmental process 186 27.43% 4.680759873118247E-31 PRKCZ, ASF1B, NOD2, PTPN6, CASP9, STAT1, TNFRSF25, PLG, MMP14, KRT18, HSPB1, HMGB1, FYN, WNT1, FOXO4, MYOZ1, EMX2, RYBP, PRKCG, RAG1, S100A7, WNT2, TGM2, TTN, KLF1, IL12A, SYK, ELMO1, NF2, MYBPC1, ID2, BTK, TRAF3, NOTCH1, GZMA, IGFBP3, GCM1, ADRB2, CD5, IGF1, NLGN1, USH2A, ANGPT1, PLP1, IFI16, ITGB2, FHL1, PRKCE, ERBB2, APAF1, PTPN11, DNM2, GSK3B, CASP2, LEP, CCL2, CD38, AGTR2, TUBB, CASC5, JUN, CTSB, F2, AKT1, REN, SOX9, ITGB1BP3, ACTB, PTPRZ1, FGF1, HDAC1, STAT5A, PICK1, CD2, PAX3, SMAD3, TNFRSF1B, TGM1, PSEN2, IL4, MAPK8, S100A4, MMP9, CD28, FGFR1, GNAQ, PTEN, MAPK1, PROX1, TAL1, CALR, IAPP, EDA2R, NEUROD1, PRL, RUNX3, MYF5, FZD1, PPARG, ROR2, GPX1, NPM1, PAWR, NR5A1, SEPT4, ACHE, PML, ZAP70, PPARGC1A, CASP3, HCLS1, ZBTB16, PIK3R1, NDN, CASP1, DCX, ABL1, PPP1R9A, CSPG4, ERN1, APP, INPP5D, GLI1, PAK7, CCR4, IL18, NHLH1, CRYAB, EP300, LMO2, ACTN2, EPB42, CTNNB1, SIAH2, APLP1, PIM1, ANXA13, PRKCA, CITED1, BCL2L1, CDC2, TLX1, CADM1, KNG1, ACTN3, MYF6, TWIST1, PAK1, E2F1, SALL1, NGFR, PAX5, EN1, SFRP1, CHAT, NTRK1, NFASC, RAG2, BCL2L10, PRKG1, ACTA1, IRF8, TP53, RYR1, DAPK1, MAGED1, TRAF1, RELA, HAND1, HAND2, CRX, LCK, FOXO1, MX1, APBB1, POU3F2, CDC7, HDAC4, NME1, CEBPB, ASCL1, PAX2, SOX10, F11R, RTN4, MAPK8IP2, 657 1835 15360 2.369751035795603 2.459271237336327E-27 3.074089046670409E-28 8.954222926834139E-28 GOTERM_BP_ALL GO:0055002~striated muscle cell development 4 0.59% 0.003696174872552823 ACTA1, MYOZ1, TTN, ACTB, 657 8 15360 11.689497716894977 0.9999999964477363 0.05742124909427648 6.838744387954765 GOTERM_BP_ALL GO:0019933~cAMP-mediated signaling 12 1.77% 0.0016807446880965993 CAP1, OPRL1, OPRD1, TGM2, GNAQ, ADRA2A, CCR3, NPR3, GNAI2, TSHR, ADRB2, ADCYAP1, 657 91 15360 3.0829444528074665 0.9998548963054629 0.0301186447991848 3.166719335312762 GOTERM_BP_ALL GO:0055001~muscle cell development 4 0.59% 0.003696174872552823 ACTA1, MYOZ1, TTN, ACTB, 657 8 15360 11.689497716894977 0.9999999964477363 0.05742124909427648 6.838744387954765 GOTERM_BP_ALL GO:0019932~second-messenger-mediated signaling 29 4.28% 2.6771014291517194E-6 GNA15, OPRD1, GNAQ, CCR3, CAP1, ERBB2, HMGB2, EGFR, NDC80, CCL2, OPRL1, TGM2, RYR1, NPR3, ADRA2A, CCR1, TSHR, SYK, CA8, PICK1, C5AR1, BTK, GNAI2, GNB2L1, GNG13, HOMER1, ADCYAP1, ADRB2, PDZD3, 657 248 15360 2.7338341434673734 0.013967052611490338 1.0418353352947829E-4 0.005121130312846223 GOTERM_BP_ALL GO:0003018~vascular process in circulatory system 8 1.18% 0.0021158470677404466 NPPB, WNT2, AGTR2, CAV1, KNG1, NPR1, NTS, ADRB2, 657 43 15360 4.349580545821387 0.9999853113825329 0.03617846522421497 3.970880809030053 GOTERM_BP_ALL GO:0006996~organelle organization and biogenesis 83 12.24% 1.1687403012022265E-5 SPTA1, PRKCZ, ASF1B, KIF17, LLGL1, HAP1, ACTL6B, CALR, CREBBP, FHL3, CAP1, FHOD1, HMGB2, BFSP2, CBX5, HMGB1, MYOZ1, NEK2, GPX1, NPM1, HMGA1, CBX2, WNT2, PML, EPB41L3, PPARGC1A, CASP3, HSP90AA1, SATB1, SET, ADRA2A, ABL1, PPP1R9A, ERBB2IP, TTN, KLF1, VIM, ELMO1, NF2, EP300, NEDD9, HMGA2, BCL2L1, WAS, NLGN1, KISS1, DOT1L, PAK1, HIST3H3, APC, FMNL1, PEX14, MYH4, EXOSC4, SYNPO, NDC80, EHD2, EXOSC1, PRKG1, ACTA1, YEATS4, SNAP91, FGD1, TP53, MIS12, CNN1, PICALM, TUBB, AKT1, NCK1, KIF5A, ACTB, DLG1, TUBA1A, HDAC1, SHANK1, CXCL1, APBB1, TUBA8, SGCG, RAC1, HDAC4, CBL, 657 1195 15360 1.623813071970348 0.05955863272604911 4.148191702421089E-4 0.02235545685368434 GOTERM_BP_ALL GO:0048856~anatomical structure development 217 32.01% 9.316525294322142E-37 FGF8, ITCH, LLGL1, YY1, FHL3, NR0B1, CAP1, KRT18, MMP14, COL1A2, FYN, MYOZ1, POU5F1, RAG1, S100A7, BMX, SYK, NF2, FOXH1, ADRBK1, POU3F3, ID2, BTK, NTS, GCM1, CLTCL1, NEDD9, NLGN1, USH2A, DVL1, ITGB2, NRIP1, FHL1, PTPN11, ERBB3, LEP, ADAMTS1, AGTR2, JUN, ITGB1BP3, SOX9, FGF1, PTPRZ1, DLG1, AES, CXCL1, PICK1, CD2, PAX3, CAV1, ACCN1, IL4, MMP9, SPTA1, POU3F1, MAPK1, PROX1, DCN, IL27RA, EDA2R, IGFBP5, ROR2, NR5A1, CRKL, THBS1, SHC3, EPHB1, ZBTB16, PPP1R9A, AKAP2, APP, GLI1, CCR4, PRKCQ, HBEGF, CRYAB, EP300, SNTG2, LMO2, ACTN2, EPB42, APLP1, KNG1, WAS, TLX1, TWIST1, MYF6, STAT3, SALL1, ERC2, APBA2, PAX5, PKP2, SFRP1, CHAT, SHC1, FGF13, NFASC, NTRK1, GRN, PRKG1, YEATS4, IRF8, HCK, RYR1, HOXD10, HAND2, CRX, FOXO1, CA9, POU3F2, RAC1, HDAC4, CEBPB, PLN, SOX10, PAX2, F11R, RTN4, NOS3, HTN1, DYRK1A, CAV3, PLG, SPP1, WNT1, EMX2, FOXO4, ALK, DLG4, WNT2, TGM2, NPR3, PPARA, KLF1, TTN, FOS, PARK2, NOTCH1, KRT17, IGFBP3, EYA1, ADRB2, TBR1, IGF1, ANGPT1, FGF7, PLP1, CASQ2, IFI16, ERBB2, APAF1, AR, CCL2, CASC5, AKT1, TFAP2B, ACTB, STAT5A, SGCG, SMAD3, CDH5, NPR1, TGM1, PSEN2, EPHB2, IKZF1, FGFR1, GNAQ, PTEN, TAL1, LHX3, NEUROD1, PRL, MYF5, FZD1, PPARG, EGFR, ZAP70, PML, ACHE, CASP3, ANKRD2, HCLS1, NDN, PIK3R1, DCX, ERBB2IP, CSPG4, NPPB, LRP2, IL18, NHLH1, ZEB1, ADD2, CD44, CTNNB1, CITED2, CEACAM1, E2F1, NGFR, EN1, RAG2, TIE1, ACTA1, FGD1, TP53, SH3GL2, RELA, NCK1, SIX3, HAND1, NR5A2, LCK, IGFBP1, APBB1, ASCL1, 657 2153 15360 2.3563595026160797 4.894902389636853E-33 1.631634129878951E-33 1.782237214687002E-33 GOTERM_BP_ALL GO:0003015~heart process 11 1.62% 4.9264432571728133E-5 SCN5A, ADRBK1, S100A1, RYR2, PRKCA, SP4, PLN, GPX1, HBEGF, SLC8A1, ADRB2, 657 51 15360 5.042528426895872 0.22805479127396922 0.0014531100915911033 0.0942000406379595 GOTERM_BP_ALL GO:0003014~renal system process 4 0.59% 0.003696174872552823 NPPB, AGTR2, KNG1, NPR1, 657 8 15360 11.689497716894977 0.9999999964477363 0.05742124909427648 6.838744387954765 GOTERM_BP_ALL GO:0003013~circulatory system process 24 3.54% 6.920105120643202E-7 RYR2, WNT2, AGTR2, PRKCA, KNG1, NPR3, REN, SLC8A1, MEOX2, NPPB, ADRBK1, SCN5A, S100A1, GUCY1B3, SP4, CAV1, HOXB2, NFE2, PLN, NPR1, GPX1, HBEGF, NTS, ADRB2, 657 167 15360 3.3598556312033465 0.003629222881997962 3.1615365342685386E-5 0.0013237973515045631 GOTERM_BP_ALL GO:0003012~muscle system process 25 3.69% 1.7762326329853925E-7 ACTN2, TRDN, PRKCA, KNG1, NOS1, CASQ2, ACTN3, SLC8A1, SCN5A, MYH4, MYL3, PRKG1, DYSF, TPM3, RYR2, ACTA1, ANKRD2, CNN1, RYR1, KBTBD10, TTN, MYBPC1, PLN, CRYAB, ADRB2, 657 167 15360 3.4998496158368195 9.327973821516844E-4 9.721126794981494E-6 3.3979007233453373E-4 GOTERM_BP_ALL GO:0000080~G1 phase of mitotic cell cycle 6 0.88% 0.0012707063163168175 TAF1, E2F1, CDC2, CDC7, FOXO4, CDC6, 657 20 15360 7.013698630136986 0.9987448954276774 0.024710311325551793 2.4030435918287907 GOTERM_BP_ALL GO:0003008~system process 110 16.22% 3.788042656625862E-9 RPGRIP1, TRPC3, HAP1, NOS1, OPN1LW, SLC8A1, MEOX2, SLC5A7, PDC, COL1A2, GRK1, KCNK3, DLG4, TPM3, WNT2, NTSR1, NPR3, BSN, ARRB2, TTN, ACCN3, NF2, ADRBK1, SNPH, S100A1, MYBPC1, PARK2, SP4, CAMK4, NTS, EYA1, HOMER1, ADRB2, NOS1AP, RHO, IGF1, NLGN1, RPGR, SLC6A4, SNCAIP, USH2A, PLP1, CASQ2, ERBB2, PTPN11, PNOC, LEP, AGTR2, REN, ACTB, SNAP25, PAX3, CAV1, ACCN1, NPR1, POU3F1, RBP4, TRDN, GNAQ, OPRD1, MAPK1, IAPP, GUCY1B3, PDE6G, BFSP2, NPHS1, GPX1, MYL3, GJA3, SNCB, DYSF, ACHE, ANKRD2, SHC3, NDN, NPPB, APP, HBEGF, CRYAB, SAG, ACTN2, CTNNB1, DLGAP2, PRKCA, KNG1, ACTN3, SCN5A, HOXB2, EN1, MYH4, NFE2, CHAT, BEST1, PRKG1, RYR2, ACTA1, OPRL1, STX1A, CNN1, RYR1, KBTBD10, KIF5A, SIX3, CRX, C5AR1, PLN, SOX10, PAX2, GNG13, AKAP5, 657 1461 15360 1.7602255288958897 1.9902178108321955E-5 2.926819595572283E-7 7.246468125554628E-6 GOTERM_BP_ALL GO:0003002~regionalization 16 2.36% 7.387385942739754E-5 CTNNB1, YY1, FGF1, MYF6, NEUROD1, FOXH1, MEOX2, APC, GLI1, MYF5, ROR2, EN1, EMX2, SFRP1, EP300, CRKL, 657 111 15360 3.3699452877535068 0.3216877793374535 0.002062485013587745 0.14122498080464396 GOTERM_BP_ALL GO:0000074~regulation of progression through cell cycle 52 7.67% 3.7310945394400445E-8 CD28, RAP1A, FGF8, PTEN, CALR, STAT1, RUNX3, CDK3, FOXO4, EGFR, NEK2, CDKN3, PML, CASP3, ZBTB17, NDN, ABL1, NF2, ACPP, ERN1, MOS, C13orf15, HCFC1, NEDD9, ADCYAP1, CCNA1, PRKCA, CDC2, CADM1, CITED2, FGF7, APC, PTPN11, AXL, SHC1, MYC, CCNT1, TP53, RYR1, STARD13, F2, CDC6, FGF1, DLG1, LCK, STAT5A, APBB1, CDC7, NME1, COPS5, EPHB2, WT1, 657 526 15360 2.311231487751098 1.9601249806122656E-4 2.3906277646368324E-6 7.13752508540999E-5 GOTERM_BP_ALL GO:0043412~biopolymer modification 141 20.80% 1.170248851991968E-11 PRKCZ, DYRK1A, EPHA7, SRC, ITCH, PTPN6, OPN1LW, STAT1, MMP14, PTPRO, CDK3, TEK, FYN, PCSK2, GRK1, NEK2, CDKN3, PRKCG, ALK, WNT2, TGM2, AURKC, SATB1, PTK2, PTPN7, TTN, BMX, IL12A, SYK, NF2, ADRBK1, UBE2I, PARK2, FOS, TNIK, BTK, SNF1LK2, CAMK4, IGFBP3, PRKACA, KSR1, PTPRH, CASK, RHO, FURIN, ABI1, CAND2, ITGB2, PRKCE, CTBP1, ERBB2, CSNK2A1, DNMT3A, PTPN11, AXL, MAPK14, GSK3B, ERBB3, PTPRT, CCL2, MAPK10, CCNT1, JUN, F2, AKT1, PTPRZ1, HDAC1, TXK, PICK1, TGM1, NPR1, PSEN2, IL4, MAPK8, EPHB2, GNA15, FGFR1, GNAQ, PTEN, MAPK1, CREBBP, DDR2, PTPN21, ROR2, EGFR, CRKL, TAF1, PML, ZAP70, PPARGC1A, HCLS1, ROS1, SET, EPHB1, PIK3R1, ZBTB16, ABL1, ERN1, LRP2, PAK7, MOS, GUCY2C, SCG5, PRKCQ, CAMK2A, EP300, NEDD4, ACP1, FES, EPB42, SIAH2, PIM1, PRKCA, CDC2, TEC, LIPE, CBLC, PIAS3, PRKAR2A, PAK1, FGR, STAMBPL1, PPP1CA, BLK, NTRK1, PTPRN, PRKG1, TIE1, HCK, TP53, MAPKAPK2, RYR1, DAPK1, KBTBD10, CSF1R, LCK, MAP3K8, CDC7, NID1, CBL, MYLK, 657 1877 15360 1.7562271476634967 6.148507936121206E-8 1.254797599159474E-9 2.238675911314658E-8 GOTERM_BP_ALL GO:0006968~cellular defense response 10 1.47% 0.0045376777407389445 NCF2, SH2D1A, C5AR1, CCL5, TYROBP, CCR3, IL4, RELA, ITGB1, CD244, 657 75 15360 3.1171993911719937 0.9999999999580782 0.06767512091930428 8.332531914297391 GOTERM_BP_ALL GO:0046209~nitric oxide metabolic process 7 1.03% 6.561932442752676E-4 CAV1, PTX3, HSP90AA1, NOS1, EGFR, AKT1, NOS3, 657 26 15360 6.29434492448191 0.9682153229568964 0.013978003850689258 1.2478487855234977 GOTERM_BP_ALL GO:0043406~positive regulation of MAP kinase activity 10 1.47% 0.002317039125204232 ERBB2, PDE6G, C5AR1, PTPN11, ELA2, ADRA2A, EGFR, SHC1, SYK, ADRB2, 657 68 15360 3.43808756379264 0.9999949080458632 0.038922120755750744 4.340582671751414 GOTERM_BP_ALL GO:0043405~regulation of MAP kinase activity 13 1.92% 9.385746532838428E-4 PRKCA, ELA2, ADRA2A, SYK, RGS4, PDE6G, ERBB2, CAV1, C5AR1, PTPN11, EGFR, SHC1, ADRB2, 657 98 15360 3.101295312645606 0.9927993707467013 0.019013750204176505 1.7802845611434082 GOTERM_BP_ALL GO:0006959~humoral immune response 10 1.47% 0.0037812855239873723 CD28, CCL2, EBI3, SH2D1A, PAX5, C1QA, MBL2, POU2AF1, CR2, CD46, 657 73 15360 3.202602114217802 0.9999999977323693 0.05785341110808695 6.990870131447258 GOTERM_BP_ALL GO:0006955~immune response 65 9.59% 1.3059951183902837E-4 CD28, CXCL2, OPRD1, INPPL1, NOD2, POU2AF1, IL27RA, FCGR3A, TNFRSF25, SH2D1A, PTX3, FYN, MBL2, LY9, RAG1, S100A7, CIITA, CXCL3, CCL8, ZAP70, CCR1, SYK, IL12A, EBI3, IL4R, INPP5D, CCR4, IL18, NOTCH1, ZEB1, GZMA, IL18R1, LCP2, CCL7, RFX1, C1QA, WAS, CADM1, VAV1, HLA-DRA, CD46, PSMB9, IFI16, CD244, PAX5, CCL5, IL16, CCL2, RAG2, FCGR2B, CTSG, IRF8, C1QBP, RYR1, TUBB, RELA, LCK, CXCL1, STAT5A, C5AR1, SMAD3, CEBPB, KIR3DL1, IL4, CR2, 657 938 15360 1.620079640934272 0.4965216898108259 0.003358146055685296 0.24953934046646475 GOTERM_BP_ALL GO:0006954~inflammatory response 38 5.60% 7.016715112697274E-9 CXCL2, CCL7, PRKCA, C1QA, KNG1, ITCH, CCR3, CD46, ITGB2, STAT3, PLA2G7, PTX3, CCL5, MBL2, THBS1, CCL2, CXCL3, CCL8, TGM2, ITIH4, ELA2, F2, CCR1, AKT1, RELA, IL8RA, CXCL1, STAT5A, FOS, CCR4, RAC1, SELE, HDAC4, TNFRSF1B, CEBPB, F11R, CR2, ADRB2, 657 301 15360 2.951501084664512 3.68651417173016E-5 5.192367842354884E-7 1.3422869127310832E-5 GOTERM_BP_ALL GO:0006952~defense response 61 9.00% 1.4206011480049988E-10 CXCL2, DARC, ITCH, NOD2, IL27RA, SH2D1A, PTX3, MBL2, THBS1, S100A7, CIITA, CXCL3, CCL8, TGM2, ELA2, CD48, CCR1, IL8RA, IL12A, NCF2, FOS, CCR4, ADRB2, IL18R1, CCL7, PRKCA, C1QA, WAS, CADM1, KNG1, CCR3, CD46, CD244, ITGB2, STAT3, PLA2G7, CCL5, CCL2, CD84, ITIH4, TYROBP, TUBB, F2, AKT1, RELA, ITGB1, CAMP, MX1, CXCL1, STAT5A, C5AR1, SELE, RAC1, TNFRSF1B, HDAC4, APOH, CEBPB, IL4, F11R, CR2, HTN1, 657 577 15360 2.4716095692568234 7.463837046195465E-7 1.332828536426689E-8 2.717589042688928E-7 GOTERM_BP_ALL GO:0006950~response to stress 90 13.27% 1.2145818951360555E-9 CXCL2, HSF1, GNAQ, MAPK1, ITCH, PTPN6, CREBBP, PLG, UPF1, MMP14, HSPB1, HMGB2, PTX3, HMGB1, MBL2, FOXO4, GPX1, EGFR, NPM1, PRKCG, S100A7, THBS1, CXCL3, CCL8, ACHE, PML, TGM2, PPARGC1A, CASP3, HSP90AA1, ELA2, CCR1, ADRA2A, PPARA, ABL1, IL8RA, TTN, ITGB3, ERN1, TNIK, FOS, CCR4, IL18, HBEGF, EP300, ADRB2, CCL7, PRKCA, C1QA, CDC2, WAS, KNG1, CITED2, CCR3, SERPIND1, FGF7, CD46, IFI16, ITGB2, STAT3, APC, NGFR, PLA2G7, CCL5, PTPN11, RPA1, MAPK14, GSK3B, CCL2, RAG2, ITIH4, TP53, CTSB, F2, AKT1, RELA, SMAD7, CXCL1, STAT5A, RAC1, SELE, HDAC4, TNFRSF1B, APOH, HSPA8, CEBPB, RAB27A, F11R, MAPK8, CR2, 657 1081 15360 1.9464473534145197 6.3813928377065565E-6 9.817558288549577E-8 2.3234767665414324E-6 GOTERM_BP_ALL GO:0019725~cellular homeostasis 31 4.57% 3.1224799395695985E-5 TRPC6, GNA15, CCL7, PRKCA, BCL2L1, CAV3, KNG1, CCR3, USH2A, CALR, KCNA5, PLG, CCL5, GRK1, GPX1, MYC, CCL2, RYR2, OPRL1, TGM2, PPARGC1A, ELA2, SLC9A3R1, RYR1, CCR1, LCK, APP, CNTNAP1, C5AR1, CCR4, PLN, 657 313 15360 2.315491560535107 0.1513069129433986 9.937946912019768E-4 0.0597156652263342 GOTERM_BP_ALL GO:0000003~reproduction 41 6.05% 5.718079118303214E-4 CD28, HSF1, ASF1B, AKAP3, CCNA1, CADM1, LIPE, ITCH, CEACAM1, CD46, NRIP1, NR0B1, PRL, CTBP1, MMP14, PAX5, ROR2, WNT1, NR5A1, CRHBP, AR, GRN, CCL2, BCL2L10, DDO, WNT2, ADAMTS1, RBMY1A1, CASC5, AKT1, SOX9, ROPN1B, STAT5A, PICK1, GLI1, CDC7, SMAD3, HOXA10, HCFC1, NOS3, ADCYAP1, 657 543 15360 1.7652648485918747 0.9504680831088285 0.012495079362308426 1.088208458354556 GOTERM_BP_ALL GO:0006936~muscle contraction 25 3.69% 1.7762326329853925E-7 ACTN2, TRDN, PRKCA, KNG1, NOS1, CASQ2, ACTN3, SLC8A1, SCN5A, MYH4, MYL3, PRKG1, DYSF, TPM3, RYR2, ACTA1, ANKRD2, CNN1, RYR1, KBTBD10, TTN, MYBPC1, PLN, CRYAB, ADRB2, 657 167 15360 3.4998496158368195 9.327973821516844E-4 9.721126794981494E-6 3.3979007233453373E-4 GOTERM_BP_ALL GO:0006935~chemotaxis 22 3.24% 1.4345787991602316E-6 CCL2, CXCL2, CXCL3, CCL8, CCL7, PRKCA, MAPK1, ELA2, CCR3, CCR1, SERPIND1, IL8RA, SYK, ITGB2, CXCL1, CNTNAP1, C5AR1, CCR4, CCL5, IL4, MAPK14, IL16, 657 149 15360 3.4519322117005298 0.00750894833629312 6.127684133827582E-5 0.00274429188333869 GOTERM_BP_ALL GO:0035150~regulation of tube size 8 1.18% 0.0018378905345538292 NPPB, WNT2, AGTR2, CAV1, KNG1, NPR1, NTS, ADRB2, 657 42 15360 4.4531419873885625 0.999936543843918 0.032448764403634534 3.4578916368744217 GOTERM_BP_ALL GO:0006928~cell motility 52 7.67% 1.5660181037172193E-11 PTEN, CAP1, PLG, MMP14, HSPB1, FYN, WNT1, EGFR, CRKL, THBS1, MSN, TPM3, WNT2, ELA2, NDN, ADRA2A, SYK, IL12A, VIM, NF2, ITGB3, ELMO1, CSPG4, PXN, CCR4, HBEGF, AKAP3, PRKCA, IGF1, CEACAM1, TWIST1, ITGB2, STAT3, NGFR, CCL5, MAPK14, IL16, NFASC, TIE1, PRKG1, TUBB, RYR1, NCK1, ITGB1, ACTB, ROPN1B, RAC1, ASCL1, MAPK8, F11R, NOS3, MMP12, 657 421 15360 2.887666894434864 8.227837144936245E-8 1.6455674600734937E-9 2.995761416713094E-8 GOTERM_BP_ALL GO:0048747~muscle fiber development 10 1.47% 2.329413142154333E-4 APP, PLG, ACTA1, MYOZ1, NOTCH1, CHAT, IGFBP3, TTN, ITGB1BP3, ACTB, 657 50 15360 4.675799086757991 0.7059531681723844 0.005599020091892837 0.44467351068910865 GOTERM_BP_ALL GO:0006919~caspase activation 8 1.18% 8.435942045615495E-4 CASP9, LCK, BCL2L10, STAT1, APAF1, TP53, SMAD3, F2, 657 37 15360 5.05491793163026 0.9881344319067732 0.01723837367904002 1.601501423492746 GOTERM_BP_ALL GO:0006917~induction of apoptosis 30 4.42% 3.212394317205344E-8 CD5, PRKCA, MAPK1, PTEN, CADM1, IFI16, PRKCE, PLG, TNFRSF25, RUNX3, NGFR, GPX1, CD38, PML, TGM2, CASP3, TP53, TUBB, DAPK1, ABL1, IL12A, ERN1, LCK, MX1, CD2, BTK, TRAF3, IL18, SMAD3, CEBPB, 657 213 15360 3.292816258280275 1.687649577297723E-4 2.1097377762568925E-6 6.145260010859133E-5 GOTERM_BP_ALL GO:0048741~skeletal muscle fiber development 10 1.47% 2.329413142154333E-4 APP, PLG, ACTA1, MYOZ1, NOTCH1, CHAT, IGFBP3, TTN, ITGB1BP3, ACTB, 657 50 15360 4.675799086757991 0.7059531681723844 0.005599020091892837 0.44467351068910865 GOTERM_BP_ALL GO:0006916~anti-apoptosis 24 3.54% 8.564300353243061E-7 CD28, CCL2, PRKCZ, BCL2L10, TGM2, BCL2L1, CDC2, DAPK1, AKT1, RELA, HDAC1, FOXO1, STAT5A, PAK7, HSPB1, HMGB1, SFRP1, CEBPB, GPX1, NPM1, CRYAB, RTN4, CASP2, MAPK8IP2, 657 169 15360 3.320094026100348 0.004489576915681748 3.878963845971306E-5 0.0016383250007079297 GOTERM_BP_ALL GO:0031328~positive regulation of cellular biosynthetic process 9 1.33% 0.004681073223871502 CD28, EBI3, STAT5A, ELA2, PRKCQ, IL4, RELA, SYK, REL, 657 62 15360 3.3937251436146703 0.9999999999803335 0.06915554628614673 8.584804708804384 GOTERM_BP_ALL GO:0006915~apoptosis 96 14.16% 6.505952327037993E-21 CD28, PRKCZ, PTEN, MAPK1, NOD2, PTPN6, CALR, IAPP, CASP9, STAT1, RUNX3, TNFRSF25, PLG, KRT18, HSPB1, HMGB1, RYBP, GPX1, NPM1, PAWR, SEPT4, PML, TGM2, CASP3, ZBTB16, PIK3R1, CASP1, ABL1, IL12A, ELMO1, ERN1, APP, INPP5D, PAK7, BTK, TRAF3, IL18, CRYAB, GZMA, IGFBP3, EP300, ADRB2, ACTN2, SIAH2, CD5, APLP1, PIM1, PRKCA, BCL2L1, CDC2, CADM1, KNG1, ACTN3, IFI16, ITGB2, PAK1, PRKCE, E2F1, APAF1, NGFR, DNM2, SFRP1, GSK3B, CASP2, CCL2, CD38, BCL2L10, AGTR2, TP53, RYR1, TUBB, CTSB, F2, DAPK1, MAGED1, AKT1, TRAF1, RELA, SOX9, HDAC1, LCK, MX1, FOXO1, STAT5A, CD2, PAX3, SMAD3, NME1, TNFRSF1B, CEBPB, PSEN2, IL4, RTN4, MAPK8, MAPK8IP2, MMP9, 657 784 15360 2.86273413474979 3.418227352625762E-17 1.4242613969274005E-18 1.2445788518701444E-17 GOTERM_BP_ALL GO:0031326~regulation of cellular biosynthetic process 19 2.80% 0.00124540010028036 CD28, APLP1, PPARGC1A, STAR, FURIN, ELA2, AKT1, RELA, SYK, REL, EBI3, STAT5A, APBB1, UPF1, HSPB1, PRKCQ, CEBPB, IL4, NR5A1, 657 189 15360 2.3502693822328524 0.998566175667754 0.024313861294654293 2.355725524915231 GOTERM_BP_ALL GO:0031325~positive regulation of cellular metabolic process 53 7.82% 2.9381164210392055E-12 CD28, POU2F1, FHL2, REL, CREBBP, NEUROD1, PPARG, FOXO4, EGFR, PRKCG, NR5A1, HMGA1, PPARGC1A, ELA2, HCLS1, PPARA, SYK, IL12A, EBI3, FOXH1, APP, GLI1, PRKCQ, NOTCH1, EP300, ADRB2, CTNNB1, PRKCA, TLX1, CITED2, MYF6, NRIP1, E2F1, NCOA1, YEATS4, TP53, RYR1, JUN, RELA, HIVEP3, SOX9, HAND1, TFAP2B, HAND2, CRX, FOXO1, STAT5A, SMAD3, CEBPB, IL4, SOX10, NCOA2, TCF4, 657 416 15360 2.9785739374780467 1.5436746880759245E-8 3.355814515160205E-10 5.6205262666253475E-9 GOTERM_BP_ALL GO:0031324~negative regulation of cellular metabolic process 41 6.05% 2.1907225903721636E-7 CTNNB1, PRKCA, POU2F1, FURIN, MYF6, TWIST1, NR0B1, NRIP1, STAT3, ORC2L, E2F1, HMGB1, PEX14, FZD1, PPARG, RYBP, PAWR, CBX2, DNAJC1, PML, IRF8, TP53, ELA2, SET, ZBTB16, JUN, CDC6, SOX9, SIX3, HAND1, NF2, APBB1, ID2, SMAD3, HDAC4, ZNF238, ZEB1, IGFBP3, TCF4, NCOA2, PDZD3, 657 387 15360 2.476844477481623 0.001150343621788008 1.1626253372809536E-5 4.1908108978638836E-4 GOTERM_BP_ALL GO:0031323~regulation of cellular metabolic process 167 24.63% 1.1798134763545681E-5 HSF1, ASF1B, NOD2, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, UPF1, HMGB2, HSPB1, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, PRKCG, CIITA, SATB1, ZBTB17, PPARA, KLF1, IL12A, SYK, NF2, EBI3, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, IGFBP3, HCFC1, EYA1, GCM1, PDZD3, ADRB2, TBR1, RFX1, FURIN, CAND2, IFI16, ITGB2, NRIP1, PRKCE, IKZF2, ORC2L, DNM2, AR, CCNT1, JUN, AKT1, CDC6, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, SMAD3, TNFRSF1B, IL4, HOXA10, IKZF1, TCF4, CD28, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, LHX3, MLLT10, CALR, CREBBP, REL, EDA2R, NEUROD1, RUNX3, MYF5, FZD1, PPARG, EGFR, NPM1, PAWR, NR5A1, RXRG, CBX2, DNAJC1, TAF1, PML, PPARGC1A, HCLS1, ELA2, SET, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, PRKCQ, NHLH1, CAMK2A, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, APLP1, PRKCA, CITED1, TLX1, CITED2, PIAS3, MYF6, TWIST1, STAT3, E2F1, SALL1, PAX5, HOXB2, PEX14, EN1, HABP4, NFE2, MYC, NCOA1, MLLT1, YEATS4, IRF8, STAR, MEIS1, TP53, MAPKAPK2, RYR1, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, HAND2, SMAD7, NR5A2, CRX, FOXO1, APBB1, POU3F2, HDAC4, CNOT3, CEBPB, ASCL1, PAX2, SOX10, WT1, IKZF4, NCOA2, 657 2873 15360 1.358960054800878 0.060105614346909086 4.159387467650433E-4 0.02256723992907217 GOTERM_BP_ALL GO:0048731~system development 180 26.55% 2.0597774642716814E-30 DYRK1A, CAV3, YY1, FHL3, NR0B1, PLG, MMP14, COL1A2, SPP1, FYN, WNT1, FOXO4, EMX2, MYOZ1, RAG1, S100A7, DLG4, ALK, WNT2, TGM2, NPR3, PPARA, TTN, KLF1, BMX, SYK, NF2, FOXH1, ADRBK1, POU3F3, PARK2, FOS, ID2, BTK, NOTCH1, IGFBP3, KRT17, GCM1, ADRB2, TBR1, IGF1, NLGN1, USH2A, FGF7, ANGPT1, PLP1, DVL1, CASQ2, IFI16, NRIP1, FHL1, ERBB2, APAF1, PTPN11, AR, ERBB3, LEP, CCL2, ADAMTS1, AKT1, SOX9, ITGB1BP3, ACTB, TFAP2B, PTPRZ1, FGF1, CXCL1, AES, STAT5A, PICK1, PAX3, CD2, SGCG, ACCN1, CDH5, SMAD3, TGM1, NPR1, PSEN2, IL4, EPHB2, IKZF1, MMP9, POU3F1, FGFR1, GNAQ, PTEN, MAPK1, PROX1, TAL1, DCN, LHX3, IL27RA, EDA2R, NEUROD1, PRL, MYF5, ROR2, EGFR, NR5A1, CRKL, THBS1, ACHE, PML, ZAP70, CASP3, ANKRD2, HCLS1, EPHB1, SHC3, ZBTB16, PIK3R1, NDN, DCX, PPP1R9A, CSPG4, NPPB, APP, LRP2, GLI1, CCR4, IL18, NHLH1, CRYAB, HBEGF, ADD2, ZEB1, SNTG2, EP300, CD44, LMO2, EPB42, CTNNB1, APLP1, TLX1, WAS, CITED2, CEACAM1, MYF6, TWIST1, STAT3, E2F1, SALL1, NGFR, ERC2, PAX5, APBA2, EN1, PKP2, CHAT, FGF13, NTRK1, NFASC, RAG2, PRKG1, TIE1, ACTA1, IRF8, HCK, FGD1, SH3GL2, RYR1, RELA, HOXD10, SIX3, HAND1, HAND2, CRX, LCK, FOXO1, APBB1, POU3F2, HDAC4, PLN, CEBPB, ASCL1, PAX2, RTN4, NOS3, HTN1, 657 1760 15360 2.391033623910336 1.0822070797283414E-26 1.0822070797283414E-27 3.9403231728849346E-27 GOTERM_BP_ALL GO:0043283~biopolymer metabolic process 290 42.77% 4.563472397124092E-7 HSF1, ITCH, POU2AF1, PTPN6, ACTL6B, OPN1LW, YY1, ORC6L, NR0B1, STAT1, MMP14, UPF1, CDK3, HMGB1, PPP1R3A, FYN, POU5F1, RAG1, PRKCG, AURKC, ZBTB17, PTPN7, BMX, SYK, NF2, FOXH1, ADRBK1, POU3F3, TNIK, ID2, BTK, KSR1, SFRS9, GCM1, MMP13, BFSP1, RHO, ABI1, YTHDC1, DOT1L, ITGB2, NRIP1, HIST3H3, PRKCE, CTBP1, CSNK2A1, DNMT3A, RPA1, PTPN11, EXOSC4, ERBB3, PTPRT, MAPK10, JUN, F2, KHDRBS2, SOX9, PTPRZ1, TXK, HOXB7, AES, PICK1, PAX3, TNFRSF1B, IL4, HOXA10, MMP9, TCF4, POU3F1, GNA15, MAPK1, PROX1, IL27RA, REL, RUNX3, CBX5, ROR2, NR5A1, CRKL, RXRG, CBX2, ELA2, EPHB1, ZBTB16, APP, PAK7, GLI1, MOS, GUCY2C, SCG5, MMP8, PRKCQ, EP300, ACP1, HMGA2, EPB42, SIAH2, DLGAP2, PIM1, APLP1, CITED1, CDC2, LIPE, TLX1, PIAS3, PRKAR2A, MMP7, MYF6, TWIST1, FGR, STAT3, SALL1, PAX5, HOXB2, PEX14, HABP4, BLK, NTRK1, PTPRN, PRKG1, NCOA1, MMP1, YEATS4, IRF8, HCK, COPS2, RYR1, HOXD10, HAND2, SMAD7, CRX, FOXO1, MAP3K8, POU3F2, HDAC4, CNOT3, CEBPB, PAX2, SOX10, WT1, IKZF4, CBL, MYLK, PRKCZ, ASF1B, DYRK1A, EPHA7, SRC, FHL2, MEOX2, YBX1, PTPRO, HMGB2, TEK, PCSK2, GRK1, FOXO4, EMX2, NEK2, RYBP, CDKN3, HMGA1, ALK, CIITA, WNT2, TGM2, SATB1, PTK2, PPARA, TTN, KLF1, IL12A, UBE2I, PARK2, FOS, HOXD4, SP4, SNF1LK2, NOTCH1, ZNF238, CAMK4, IGFBP3, HCFC1, PRKACA, EYA1, ADRB2, TBR1, PTPRH, RFX1, IGF1, CASK, FURIN, CAND2, IFI16, IKZF2, ORC2L, ERBB2, AXL, PRTN3, MAPK14, AR, GSK3B, CCL2, EXOSC1, RBMY1A1, CCNT1, AKT1, CDC6, TFAP2B, HDAC1, STAT5A, SMAD3, TGM1, NPR1, PSEN2, MAPK8, EPHB2, IKZF1, RUNX1T1, FGFR1, GNAQ, PTEN, POU2F1, TAL1, LHX3, MLLT10, CALR, CREBBP, NEUROD1, DDR2, MYF5, PTPN21, PPARG, HGS, EGFR, PAWR, TAF1, ACHE, PML, ZAP70, PPARGC1A, HCLS1, ROS1, SET, PIK3R1, NDN, ABL1, ERN1, HOXA9, LRP2, NHLH1, CAMK2A, ZEB1, NEDD4, FES, CTNNB1, PRKCA, TEC, CBLC, CITED2, PSMB9, PAK1, E2F1, STAMBPL1, PPP1CA, EN1, NFE2, MYC, RAG2, TIE1, MLLT1, MEIS1, TP53, MAPKAPK2, DAPK1, MAGED1, KBTBD10, RELA, HIVEP3, SIX3, HAND1, RPA4, CSF1R, NR5A2, LCK, CDC7, NID1, COPS5, ASCL1, NCOA2, 657 5361 15360 1.2646723886959685 0.002394776879901528 2.2200206759470653E-5 8.729817642993964E-4 GOTERM_BP_ALL GO:0014706~striated muscle development 20 2.95% 4.491314816466427E-8 ACTA1, PTEN, TTN, ITGB1BP3, ACTB, TWIST1, MYF6, APP, PLG, MYF5, SMAD3, FOXO4, MYOZ1, HDAC4, CHAT, NOTCH1, PLN, IGFBP3, EP300, ADRB2, 657 101 15360 4.6295040462950405 2.3594584634445415E-4 2.776157157602377E-6 8.591813903668921E-5 GOTERM_BP_ALL GO:0043281~regulation of caspase activity 9 1.33% 0.0019405741299841506 CASP9, LCK, BCL2L10, STAT1, APAF1, TP53, SMAD3, GPX1, F2, 657 54 15360 3.896499238964992 0.9999630402888394 0.03377887788296419 3.6477035042141615 GOTERM_BP_ALL GO:0043280~positive regulation of caspase activity 8 1.18% 0.0018378905345538292 CASP9, LCK, BCL2L10, STAT1, APAF1, TP53, SMAD3, F2, 657 42 15360 4.4531419873885625 0.999936543843918 0.032448764403634534 3.4578916368744217 GOTERM_BP_ALL GO:0006898~receptor-mediated endocytosis 8 1.18% 0.002768199674819786 CAP1, LRP2, SLC9A3, RAC1, PICALM, CBL, ADRB2, CLTCL1, 657 45 15360 4.156265854895992 0.9999995270559934 0.04476667638755061 5.164717953940268 GOTERM_BP_ALL GO:0006897~endocytosis 20 2.95% 7.930253378359816E-4 APLP1, SYNJ1, SLC9A3, VAV1, ELA2, SH3GL2, PICALM, RYR1, ELMO1, CAP1, APP, LRP1, LRP2, PTX3, RAC1, DNM2, EHD2, CBL, CLTCL1, ADRB2, 657 197 15360 2.373502074496442 0.9845200260066281 0.01634015807409195 1.5061891085153212 GOTERM_BP_ALL GO:0006887~exocytosis 12 1.77% 0.0035639674214419706 ROPN1B, SNPH, SNAP25, CCL8, RPH3AL, STX1A, AKAP3, CCL5, NLGN1, RYR1, RAB3B, SYK, 657 100 15360 2.805479452054794 0.999999992866987 0.055917298900479806 6.6019706658507875 GOTERM_BP_ALL GO:0048699~generation of neurons 25 3.69% 0.0014629664825904051 GNAQ, PTEN, TLX1, NLGN1, TWIST1, NGFR, FYN, PTPN11, EMX2, EN1, CHAT, NFASC, PRKG1, WNT2, NDN, PTPRZ1, APP, PICK1, APBB1, CCR4, POU3F2, CEBPB, PAX2, ASCL1, RTN4, 657 289 15360 2.0224044492897884 0.9995435602645365 0.027682799063616814 2.76182642084869 GOTERM_BP_ALL GO:0046068~cGMP metabolic process 5 0.74% 0.002341985765689827 GUCY1B3, GUCY1A2, GUCY2C, NPR1, PDZD3, 657 14 15360 8.349641226353555 0.9999955349251258 0.03908376737508279 4.3863294325831585 GOTERM_BP_ALL GO:0006875~cellular metal ion homeostasis 20 2.95% 2.604914511679369E-6 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, CNTNAP1, C5AR1, CCR4, CCL5, PLN, 657 130 15360 3.5967685282753776 0.013593007916258726 1.0213089376243101E-4 0.004983044441930762 GOTERM_BP_ALL GO:0006874~cellular calcium ion homeostasis 20 2.95% 8.566054754646166E-7 CCL2, TRPC6, GNA15, RYR2, OPRL1, TGM2, CCL7, PRKCA, ELA2, KNG1, RYR1, CCR3, CCR1, CALR, LCK, CNTNAP1, C5AR1, CCR4, CCL5, PLN, 657 121 15360 3.864296765915695 0.004490494540043577 3.8140010749532216E-5 0.0016386606097706924 GOTERM_BP_ALL GO:0006873~cellular ion homeostasis 27 3.98% 1.5431583899618612E-6 GNA15, TRPC6, CCL7, BCL2L1, PRKCA, CAV3, KNG1, CCR3, CALR, KCNA5, CCL5, GRK1, MYC, CCL2, RYR2, OPRL1, TGM2, SLC9A3R1, ELA2, RYR1, CCR1, LCK, APP, CNTNAP1, C5AR1, CCR4, PLN, 657 214 15360 2.949686339777237 0.008074981195551723 6.538302724823364E-5 0.002951997393529915 GOTERM_BP_ALL GO:0043170~macromolecule metabolic process 351 51.77% 4.833740052614232E-4 HSF1, SLC2A2, PPIB, XPO1, ITCH, NOD2, LLGL1, POU2AF1, PTPN6, ACTL6B, OPN1LW, YY1, PORCN, ORC6L, NR0B1, CASP9, STAT1, MMP14, UPF1, CDK3, HMGB1, PPP1R3A, FYN, POU5F1, RAG1, PRKCG, AURKC, ZBTB17, SLC9A3R1, PTPN7, BMX, SYK, NF2, EBI3, FOXH1, ADRBK1, POU3F3, TNIK, ID2, BTK, KSR1, SFRS9, GCM1, CLTCL1, MMP13, BFSP1, RHO, ABI1, YTHDC1, DOT1L, NRIP1, ITGB2, HIST3H3, PRKCE, CTBP1, CSNK2A1, DNMT3A, RPA1, PTPN11, EXOSC4, ERBB3, PTPRT, LEP, ADAMTS1, MAPK10, ITIH4, TUBB, JUN, CTSB, F2, KHDRBS2, SOX9, PTPRZ1, TXK, AES, HOXB7, PICK1, PAX3, CAV1, TNFRSF1B, IL4, HOXA10, MMP12, TCF4, MMP9, GNA15, POU3F1, SPTA1, MAPK1, PROX1, IL27RA, REL, RUNX3, CBX5, ROR2, NR5A1, CRKL, RXRG, CBX2, HSP90AA1, ELA2, EPHB1, ZBTB16, APP, GLI1, PAK7, MMP8, SCG5, GUCY2C, MOS, PRKCQ, CRYAB, EP300, MAGI1, ACTN2, HMGA2, ACP1, EPB42, SIAH2, DLGAP2, APLP1, TRPC4, PIM1, CITED1, C1QA, CDC2, TLX1, HK3, WAS, LIPE, PIAS3, PRKAR2A, MMP7, MYF6, TRPM2, TWIST1, FGR, STAT3, PCSK1, SALL1, PAX5, HOXB2, PEX14, HABP4, BLK, NTRK1, PTPRN, PRKG1, CTSG, NCOA1, MMP1, YEATS4, IRF8, HCK, COPS2, MIS12, RYR1, TRAF1, HOXD10, HAND2, SMAD7, CRX, FOXO1, MAP3K8, POU3F2, RAC1, HDAC4, CNOT3, HSPA8, CEBPB, PAX2, SOX10, WT1, IKZF4, MAPK8IP2, CBL, MYLK, PRKCZ, ASF1B, DYRK1A, EPHA7, SRC, FHL2, MEOX2, YBX1, PLG, PTPRO, HMGB2, HSPB1, TEK, PCSK2, GRK1, FOXO4, EMX2, NEK2, RYBP, CDKN3, HMGA1, DLG4, CIITA, ALK, WNT2, TGM2, SATB1, PTK2, PPARA, TTN, KLF1, IL12A, UBE2I, PARK2, PXN, FOS, HOXD4, SP4, SNF1LK2, NOTCH1, ZNF238, CAMK4, GZMA, IGFBP3, HCFC1, PRKACA, EYA1, ADRB2, TBR1, PTPRH, RFX1, IGF1, CASK, FURIN, IFI16, CAND2, IKZF2, ORC2L, ERBB2, PRTN3, AXL, MAPK14, GSK3B, AR, CASP2, CCL2, EXOSC1, RBMY1A1, CCNT1, PICALM, AKT1, CDC6, REN, TFAP2B, TUBA1A, HDAC1, STAT5A, TUBA8, AP2M1, SMAD3, TGM1, NPR1, PSEN2, MAPK8, EPHB2, IKZF1, CD28, RUNX1T1, FGFR1, GNAQ, PTEN, POU2F1, TAL1, LHX3, MLLT10, CALR, CREBBP, NEUROD1, DDR2, MYF5, PTPN21, PPARG, MBL2, HGS, EGFR, NPM1, PAWR, DNAJC1, TAF1, ACHE, PML, ZAP70, PPARGC1A, CASP3, HCLS1, ROS1, SET, PIK3R1, NDN, CASP1, ABL1, ERN1, HOXA9, LRP2, MME, SI, IL18, NHLH1, CAMK2A, ZEB1, NEDD4, FES, CTNNB1, PRKCA, TEC, CBLC, CITED2, CD46, PSMB9, PAK1, E2F1, APC, STAMBPL1, PPP1CA, EN1, NFE2, STX12, SLC2A4, MYC, RAG2, TIE1, MLLT1, MEIS1, TP53, MAPKAPK2, DAPK1, MAGED1, KBTBD10, RELA, HIVEP3, NCK1, SIX3, HAND1, RPA4, CSF1R, NR5A2, LCK, APBB1, CDC7, NID1, COPS5, ASCL1, CR2, NCOA2, 657 7216 15360 1.1371989186890625 0.92115418332432 0.010889674451346365 0.9206465842018563 GOTERM_BP_ALL GO:0048666~neuron development 18 2.65% 0.0038140525224349834 PRKG1, GNAQ, PTEN, NLGN1, NDN, PTPRZ1, APP, PICK1, APBB1, NGFR, POU3F2, PTPN11, EN1, CHAT, ASCL1, PAX2, RTN4, NFASC, 657 193 15360 2.180424444602172 0.9999999980922558 0.05817177388236605 7.0493746760652565 GOTERM_BP_ALL GO:0019538~protein metabolic process 218 32.15% 5.160785288924518E-8 HSF1, PPIB, XPO1, ITCH, NOD2, LLGL1, PTPN6, ACTL6B, OPN1LW, PORCN, CASP9, STAT1, MMP14, UPF1, CDK3, FYN, PRKCG, AURKC, SLC9A3R1, PTPN7, BMX, SYK, NF2, EBI3, ADRBK1, TNIK, BTK, KSR1, CLTCL1, MMP13, RHO, ABI1, ITGB2, PRKCE, CTBP1, CSNK2A1, PTPN11, ERBB3, PTPRT, ADAMTS1, MAPK10, TUBB, JUN, CTSB, F2, PTPRZ1, TXK, PICK1, CAV1, IL4, MMP12, MMP9, SPTA1, GNA15, MAPK1, REL, ROR2, CRKL, HSP90AA1, ELA2, EPHB1, ZBTB16, PAK7, MOS, GUCY2C, SCG5, MMP8, PRKCQ, CRYAB, EP300, MAGI1, ACP1, ACTN2, EPB42, SIAH2, PIM1, TRPC4, APLP1, CDC2, C1QA, LIPE, WAS, HK3, PIAS3, MMP7, PRKAR2A, FGR, PCSK1, PEX14, NTRK1, BLK, PTPRN, PRKG1, CTSG, MMP1, HCK, MIS12, RYR1, TRAF1, MAP3K8, RAC1, HSPA8, CEBPB, MAPK8IP2, CBL, MYLK, PRKCZ, DYRK1A, EPHA7, SRC, PLG, PTPRO, HSPB1, TEK, PCSK2, GRK1, NEK2, CDKN3, HMGA1, ALK, DLG4, WNT2, TGM2, SATB1, PTK2, TTN, IL12A, UBE2I, PXN, PARK2, SNF1LK2, CAMK4, IGFBP3, GZMA, PRKACA, HCFC1, ADRB2, PTPRH, CASK, FURIN, CAND2, ERBB2, AXL, PRTN3, GSK3B, MAPK14, CASP2, CCL2, CCNT1, PICALM, AKT1, REN, HDAC1, TUBA1A, STAT5A, TUBA8, AP2M1, SMAD3, NPR1, TGM1, PSEN2, MAPK8, EPHB2, CD28, FGFR1, GNAQ, PTEN, CALR, CREBBP, DDR2, PTPN21, MBL2, HGS, EGFR, DNAJC1, TAF1, ZAP70, PML, ACHE, CASP3, PPARGC1A, HCLS1, ROS1, SET, PIK3R1, CASP1, ABL1, ERN1, LRP2, MME, IL18, CAMK2A, NEDD4, FES, PRKCA, TEC, CBLC, CD46, PSMB9, PAK1, APC, STAMBPL1, PPP1CA, STX12, TIE1, TP53, MAPKAPK2, DAPK1, KBTBD10, RELA, NCK1, CSF1R, LCK, APBB1, CDC7, NID1, COPS5, CR2, 657 3691 15360 1.3808238972002735 2.7111090882236955E-4 3.1528748671849627E-6 9.872499675545043E-5 GOTERM_BP_ALL GO:0012502~induction of programmed cell death 30 4.42% 3.5689791093956435E-8 CD5, PRKCA, MAPK1, PTEN, CADM1, IFI16, PRKCE, PLG, TNFRSF25, RUNX3, NGFR, GPX1, CD38, PML, TGM2, CASP3, TP53, TUBB, DAPK1, ABL1, IL12A, ERN1, LCK, MX1, CD2, BTK, TRAF3, IL18, SMAD3, CEBPB, 657 214 15360 3.277429266419152 1.8749658622119192E-4 2.314987022966619E-6 6.827400917952531E-5 GOTERM_BP_ALL GO:0048646~anatomical structure formation 23 3.39% 8.07749436899904E-6 TIE1, CTNNB1, FGFR1, PML, PTEN, TLX1, CASC5, CEACAM1, ANGPT1, FGF1, HAND1, HAND2, CSPG4, NPPB, PLG, ERBB2, MMP14, IL18, SMAD3, FOXO4, NPR1, THBS1, S100A7, 657 179 15360 3.004004999872452 0.041551384114775436 2.9467412238926016E-4 0.015450993322985163 GOTERM_BP_ALL GO:0012501~programmed cell death 96 14.16% 1.2148503112590477E-20 CD28, PRKCZ, PTEN, MAPK1, NOD2, PTPN6, CALR, IAPP, CASP9, STAT1, RUNX3, TNFRSF25, PLG, KRT18, HSPB1, HMGB1, RYBP, GPX1, NPM1, PAWR, SEPT4, PML, TGM2, CASP3, ZBTB16, PIK3R1, CASP1, ABL1, IL12A, ELMO1, ERN1, APP, INPP5D, PAK7, BTK, TRAF3, IL18, CRYAB, GZMA, IGFBP3, EP300, ADRB2, ACTN2, SIAH2, CD5, APLP1, PIM1, PRKCA, BCL2L1, CDC2, CADM1, KNG1, ACTN3, IFI16, ITGB2, PAK1, PRKCE, E2F1, APAF1, NGFR, DNM2, SFRP1, GSK3B, CASP2, CCL2, CD38, BCL2L10, AGTR2, TP53, RYR1, TUBB, CTSB, F2, DAPK1, MAGED1, AKT1, TRAF1, RELA, SOX9, HDAC1, LCK, MX1, FOXO1, STAT5A, CD2, PAX3, SMAD3, NME1, TNFRSF1B, CEBPB, PSEN2, IL4, RTN4, MAPK8, MAPK8IP2, MMP9, 657 791 15360 2.8374002043537745 6.382823535355037E-17 2.5531294141420147E-18 2.3239902931616482E-17 GOTERM_BP_ALL GO:0002682~regulation of immune system process 12 1.77% 0.003849652423811441 LCK, C1QA, FYN, MBL2, SMAD3, NOD2, IL4, CR2, CD46, IL12A, IL27RA, SYK, 657 101 15360 2.777702427777024 0.9999999984188378 0.05853001807050329 7.112897757629987 GOTERM_BP_ALL GO:0010468~regulation of gene expression 155 22.86% 1.6451570526610887E-4 HSF1, ASF1B, NOD2, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, UPF1, HMGB2, HSPB1, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, CIITA, SATB1, ZBTB17, PPARA, KLF1, SYK, EBI3, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, HCFC1, EYA1, GCM1, ADRB2, TBR1, RFX1, FURIN, CAND2, IFI16, NRIP1, IKZF2, ORC2L, DNMT3A, DNM2, AR, CCNT1, JUN, AKT1, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PICK1, PAX3, SMAD3, IL4, HOXA10, IKZF1, TCF4, CD28, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, LHX3, MLLT10, CALR, CREBBP, REL, EDA2R, NEUROD1, RUNX3, MYF5, FZD1, PPARG, GPX1, NPM1, PAWR, NR5A1, RXRG, CBX2, TAF1, PML, PPARGC1A, HCLS1, ELA2, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, PRKCQ, NHLH1, CAMK2A, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, APLP1, CITED1, TLX1, CITED2, PIAS3, TWIST1, MYF6, STAT3, E2F1, SALL1, PAX5, HOXB2, PEX14, EN1, HABP4, NFE2, MYC, NCOA1, MLLT1, YEATS4, IRF8, MEIS1, TP53, RYR1, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, HAND2, SMAD7, NR5A2, CRX, FOXO1, APBB1, POU3F2, HDAC4, CNOT3, CEBPB, ASCL1, PAX2, SOX10, WT1, IKZF4, NCOA2, 657 2760 15360 1.3129508305208126 0.5787111702511817 0.004069229402818841 0.3142471563745475 GOTERM_BP_ALL GO:0006816~calcium ion transport 15 2.21% 4.617111221425692E-4 TRPC6, SLC8A2, RYR2, CCL8, TRPC3, TRPC4, SCN3A, CAV3, RYR1, SLC8A1, TRPM2, ITPR1, FYN, PLN, ADRB2, 657 117 15360 2.997307106896148 0.9116448176220051 0.010448881814486333 0.8795594107930294 GOTERM_BP_ALL GO:0006809~nitric oxide biosynthetic process 7 1.03% 6.561932442752676E-4 CAV1, PTX3, HSP90AA1, NOS1, EGFR, AKT1, NOS3, 657 26 15360 6.29434492448191 0.9682153229568964 0.013978003850689258 1.2478487855234977 GOTERM_BP_ALL GO:0051726~regulation of cell cycle 52 7.67% 4.4616221560510965E-8 CD28, RAP1A, FGF8, PTEN, CALR, STAT1, RUNX3, CDK3, FOXO4, EGFR, NEK2, CDKN3, PML, CASP3, ZBTB17, NDN, ABL1, NF2, ACPP, ERN1, MOS, C13orf15, HCFC1, NEDD9, ADCYAP1, CCNA1, PRKCA, CDC2, CADM1, CITED2, FGF7, APC, PTPN11, AXL, SHC1, MYC, CCNT1, TP53, RYR1, STARD13, F2, CDC6, FGF1, DLG1, LCK, STAT5A, APBB1, CDC7, NME1, COPS5, EPHB2, WT1, 657 529 15360 2.2981243148526986 2.3438616081883357E-4 2.7906346007355864E-6 8.535012341326365E-5 GOTERM_BP_ALL GO:0006796~phosphate metabolic process 108 15.93% 2.976491702592071E-18 PRKCZ, DYRK1A, EPHA7, SRC, PTPN6, STAT1, PTPRO, CDK3, TEK, FYN, GRK1, NEK2, CDKN3, PRKCG, ALK, WNT2, AURKC, PTPN7, PTK2, BMX, TTN, SYK, IL12A, NF2, ADRBK1, TNIK, BTK, SNF1LK2, CAMK4, IGFBP3, KSR1, PRKACA, PTPRH, CASK, ABI1, ITGB2, PRKCE, CTBP1, CSNK2A1, ERBB2, PTPN11, AXL, GSK3B, MAPK14, ERBB3, PTPRT, CCL2, MAPK10, CCNT1, JUN, F2, AKT1, PTPRZ1, TXK, PICK1, NPR1, IL4, MAPK8, EPHB2, FGFR1, MAPK1, PTEN, INPPL1, DDR2, PTPN21, ROR2, EGFR, CRKL, TAF1, ZAP70, HCLS1, ROS1, EPHB1, PIK3R1, ABL1, ERN1, INPP5D, PAK7, MOS, GUCY2C, PRKCQ, CAMK2A, ACP1, FES, PIM1, PRKCA, CDC2, TEC, LIPE, CBLC, PRKAR2A, PAK1, FGR, PPP1CA, NTRK1, BLK, PTPRN, PRKG1, TIE1, SYNJ1, HCK, MAPKAPK2, DAPK1, CSF1R, LCK, MAP3K8, CDC7, MYLK, 657 1036 15360 2.4371925741788756 1.563848740541874E-14 5.21282913513958E-16 5.693983662342041E-15 GOTERM_BP_ALL GO:0006793~phosphorus metabolic process 108 15.93% 2.976491702592071E-18 PRKCZ, DYRK1A, EPHA7, SRC, PTPN6, STAT1, PTPRO, CDK3, TEK, FYN, GRK1, NEK2, CDKN3, PRKCG, ALK, WNT2, AURKC, PTPN7, PTK2, BMX, TTN, SYK, IL12A, NF2, ADRBK1, TNIK, BTK, SNF1LK2, CAMK4, IGFBP3, KSR1, PRKACA, PTPRH, CASK, ABI1, ITGB2, PRKCE, CTBP1, CSNK2A1, ERBB2, PTPN11, AXL, GSK3B, MAPK14, ERBB3, PTPRT, CCL2, MAPK10, CCNT1, JUN, F2, AKT1, PTPRZ1, TXK, PICK1, NPR1, IL4, MAPK8, EPHB2, FGFR1, MAPK1, PTEN, INPPL1, DDR2, PTPN21, ROR2, EGFR, CRKL, TAF1, ZAP70, HCLS1, ROS1, EPHB1, PIK3R1, ABL1, ERN1, INPP5D, PAK7, MOS, GUCY2C, PRKCQ, CAMK2A, ACP1, FES, PIM1, PRKCA, CDC2, TEC, LIPE, CBLC, PRKAR2A, PAK1, FGR, PPP1CA, NTRK1, BLK, PTPRN, PRKG1, TIE1, SYNJ1, HCK, MAPKAPK2, DAPK1, CSF1R, LCK, MAP3K8, CDC7, MYLK, 657 1036 15360 2.4371925741788756 1.563848740541874E-14 5.21282913513958E-16 5.693983662342041E-15 GOTERM_BP_ALL GO:0045944~positive regulation of transcription from RNA polymerase II promoter 29 4.28% 8.467722040356951E-10 CTNNB1, POU2F1, TLX1, NEUROD1, NRIP1, E2F1, PPARG, NR5A1, PPARGC1A, TP53, JUN, PPARA, SOX9, HAND1, TFAP2B, HAND2, FOXH1, CRX, FOXO1, APP, STAT5A, GLI1, SMAD3, NOTCH1, IL4, SOX10, EP300, NCOA2, ADRB2, 657 171 15360 3.964858874736308 4.448931285705449E-6 7.061811146957808E-8 1.6198624330776568E-6 GOTERM_BP_ALL GO:0051704~multi-organism process 26 3.83% 0.0027369208500816608 XPO1, MAPK1, LIPE, ITCH, NOD2, CEACAM1, IL27RA, IFI16, FGR, STAT1, PRL, PTX3, CCL5, CRHBP, S100A7, GRN, CCL8, RELA, IL12A, CAMP, MX1, APP, STAT5A, SMAD3, ADCYAP1, HTN1, 657 320 15360 1.8995433789954337 0.9999994423287958 0.04440804132167908 5.107798690107823 GOTERM_BP_ALL GO:0043085~positive regulation of catalytic activity 28 4.13% 3.9765910689851116E-6 GNA15, GNAQ, CASP9, STAT1, CAP1, PDE6G, ERBB2, APAF1, PTPN11, EGFR, SHC1, BCL2L10, TP53, ELA2, F2, ADRA2A, ABL1, SYK, LCK, ERN1, PICK1, C5AR1, SMAD3, PSEN2, GNB2L1, IRS1, ADCYAP1, ADRB2, 657 239 15360 2.738961808142756 0.020676303358780568 1.5138746018250604E-4 0.007606884429334215 GOTERM_BP_ALL GO:0045941~positive regulation of transcription 43 6.34% 1.5118072965655072E-10 CTNNB1, POU2F1, TLX1, CITED2, FHL2, CREBBP, MYF6, REL, NRIP1, NEUROD1, E2F1, PPARG, FOXO4, HMGA1, NR5A1, NCOA1, YEATS4, PPARGC1A, TP53, RYR1, JUN, PPARA, RELA, HIVEP3, SOX9, TFAP2B, HAND1, HAND2, CRX, FOXH1, FOXO1, APP, STAT5A, GLI1, SMAD3, NOTCH1, CEBPB, SOX10, IL4, EP300, NCOA2, TCF4, ADRB2, 657 326 15360 3.0837325265428466 7.943032641621883E-7 1.3935150477983882E-8 2.89206458781166E-7 GOTERM_BP_ALL GO:0043069~negative regulation of programmed cell death 32 4.72% 1.8667621449791866E-8 CD28, PRKCZ, PIM1, PTEN, BCL2L1, CDC2, KRT18, HSPB1, HMGB1, SFRP1, GPX1, NPM1, GSK3B, CASP2, CCL2, BCL2L10, TGM2, CASP3, PIK3R1, DAPK1, AKT1, RELA, HDAC1, FOXO1, STAT5A, PAK7, CEBPB, IL4, CRYAB, RTN4, MAPK8, MAPK8IP2, 657 233 15360 3.210849158288749 9.807487435165019E-5 1.3077282650097999E-6 3.571087178189103E-5 GOTERM_BP_ALL GO:0043068~positive regulation of programmed cell death 37 5.46% 2.8058547284736344E-10 CD5, PRKCA, PTEN, MAPK1, CADM1, KNG1, IFI16, PRKCE, PLG, TNFRSF25, RUNX3, NGFR, DNM2, GPX1, PAWR, CD38, PML, TGM2, CASP3, TP53, TUBB, DAPK1, ZBTB16, ABL1, IL12A, ERN1, LCK, MX1, CD2, BTK, TRAF3, IL18, SMAD3, CEBPB, IGFBP3, MMP9, ADRB2, 657 256 15360 3.3789954337899544 1.4741948350938117E-6 2.4569931755813457E-8 5.3675571765055E-7 GOTERM_BP_ALL GO:0051674~localization of cell 52 7.67% 1.5660181037172193E-11 PTEN, CAP1, PLG, MMP14, HSPB1, FYN, WNT1, EGFR, CRKL, THBS1, MSN, TPM3, WNT2, ELA2, NDN, ADRA2A, SYK, IL12A, VIM, NF2, ITGB3, ELMO1, CSPG4, PXN, CCR4, HBEGF, AKAP3, PRKCA, IGF1, CEACAM1, TWIST1, ITGB2, STAT3, NGFR, CCL5, MAPK14, IL16, NFASC, TIE1, PRKG1, TUBB, RYR1, NCK1, ITGB1, ACTB, ROPN1B, RAC1, ASCL1, MAPK8, F11R, NOS3, MMP12, 657 421 15360 2.887666894434864 8.227837144936245E-8 1.6455674600734937E-9 2.995761416713094E-8 GOTERM_BP_ALL GO:0043067~regulation of programmed cell death 78 11.50% 4.8213933341990204E-21 CD28, PRKCZ, PTEN, MAPK1, NOD2, CALR, CASP9, STAT1, PLG, TNFRSF25, RUNX3, KRT18, HSPB1, HMGB1, GPX1, NPM1, PAWR, SEPT4, PML, TGM2, CASP3, ZBTB16, PIK3R1, CASP1, ABL1, IL12A, ERN1, PAK7, BTK, TRAF3, IL18, CRYAB, IGFBP3, ADRB2, ACTN2, CD5, PIM1, PRKCA, BCL2L1, CDC2, CADM1, KNG1, ACTN3, IFI16, PRKCE, APAF1, NGFR, DNM2, SFRP1, GSK3B, CASP2, CCL2, BCL2L10, CD38, TP53, TUBB, CTSB, F2, DAPK1, MAGED1, AKT1, TRAF1, RELA, SOX9, HDAC1, LCK, FOXO1, MX1, STAT5A, CD2, SMAD3, NME1, CEBPB, IL4, RTN4, MAPK8, MAPK8IP2, MMP9, 657 544 15360 3.3521353746978244 2.5331600577881654E-17 1.1013739381687675E-18 9.223252613385993E-18 GOTERM_BP_ALL GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 44 6.49% 1.1280901465614518E-10 CTNNB1, POU2F1, TLX1, CITED2, FHL2, CREBBP, MYF6, REL, NRIP1, NEUROD1, E2F1, PPARG, FOXO4, HMGA1, NR5A1, PRKCG, NCOA1, YEATS4, PPARGC1A, TP53, RYR1, JUN, PPARA, RELA, HIVEP3, SOX9, TFAP2B, HAND1, HAND2, CRX, FOXH1, APP, FOXO1, STAT5A, GLI1, SMAD3, NOTCH1, CEBPB, SOX10, IL4, EP300, NCOA2, TCF4, ADRB2, 657 336 15360 3.0615351163296367 5.926982282744575E-7 1.077633460244698E-8 2.1580188747094553E-7 GOTERM_BP_ALL GO:0043066~negative regulation of apoptosis 32 4.72% 1.3708148521379534E-8 CD28, PRKCZ, PIM1, PTEN, BCL2L1, CDC2, KRT18, HSPB1, HMGB1, SFRP1, GPX1, NPM1, GSK3B, CASP2, CCL2, BCL2L10, TGM2, CASP3, PIK3R1, DAPK1, AKT1, RELA, HDAC1, FOXO1, STAT5A, PAK7, CEBPB, IL4, CRYAB, RTN4, MAPK8, MAPK8IP2, 657 230 15360 3.2527297994838196 7.202001917394618E-5 9.86610646735997E-7 2.6223477744835577E-5 GOTERM_BP_ALL GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 34 5.01% 4.557125365703172E-6 CTNNB1, POU2F1, MYF6, TWIST1, NRIP1, NR0B1, STAT3, ORC2L, E2F1, HMGB1, PEX14, FZD1, PPARG, RYBP, PAWR, CBX2, PML, IRF8, TP53, SET, ZBTB16, CDC6, SOX9, SIX3, HAND1, NF2, ID2, SMAD3, HDAC4, ZNF238, ZEB1, NCOA2, TCF4, PDZD3, 657 328 15360 2.423432453502617 0.02365882707409328 1.7100817091886267E-4 0.00871735186261935 GOTERM_BP_ALL GO:0002521~leukocyte differentiation 17 2.51% 1.9004024126328237E-5 RAG2, CTNNB1, ZAP70, RYR1, PIK3R1, SYK, IFI16, LCK, STAT5A, ERBB2, CD2, ID2, HDAC4, IL4, RAG1, MMP9, NTRK1, 657 111 15360 3.5805668682381007 0.09502511904718358 6.523890070554428E-4 0.03634814897079952 GOTERM_BP_ALL GO:0008632~apoptotic program 15 2.21% 8.723825408360257E-6 BCL2L10, CASP3, BCL2L1, TP53, F2, AKT1, LCK, CASP9, STAT1, APAF1, SMAD3, GPX1, PSEN2, GZMA, CASP2, 657 82 15360 4.276645506181089 0.04480061350685749 3.160547243522549E-4 0.016687226540623712 GOTERM_BP_ALL GO:0043065~positive regulation of apoptosis 37 5.46% 2.2436333404525375E-10 CD5, PRKCA, PTEN, MAPK1, CADM1, KNG1, IFI16, PRKCE, PLG, TNFRSF25, RUNX3, NGFR, DNM2, GPX1, PAWR, CD38, PML, TGM2, CASP3, TP53, TUBB, DAPK1, ZBTB16, ABL1, IL12A, ERN1, LCK, MX1, CD2, BTK, TRAF3, IL18, SMAD3, CEBPB, IGFBP3, MMP9, ADRB2, 657 254 15360 3.4056016970481426 1.1788041135440963E-6 1.997974230505406E-8 4.292036170916447E-7 GOTERM_BP_ALL GO:0002520~immune system development 30 4.42% 5.398506889947535E-8 EPB42, CTNNB1, TAL1, TLX1, IL27RA, IFI16, PRL, ERBB2, RAG1, CRKL, LEP, NTRK1, RAG2, ZAP70, IRF8, HCLS1, RYR1, PIK3R1, ZBTB16, KLF1, SYK, LCK, STAT5A, CD2, ID2, HDAC4, ADD2, IL4, MMP9, LMO2, 657 218 15360 3.217292949604122 2.835973381151158E-4 3.260196518195535E-6 1.0327257066178319E-4 GOTERM_BP_ALL GO:0031098~stress-activated protein kinase signaling pathway 11 1.62% 7.378931014319075E-4 MAPK10, TNIK, ROR2, MAPK8IP1, MAPK8, CRKL, MAPK8IP2, SYK, SH2D3C, PAK1, EDA2R, 657 70 15360 3.6738421395955636 0.9793144817350911 0.015393574517893915 1.4021760497128333 GOTERM_BP_ALL GO:0008624~induction of apoptosis by extracellular signals 8 1.18% 7.097808608516732E-4 CD38, TNFRSF25, CD5, PRKCA, CASP3, BTK, IL18, DAPK1, 657 36 15360 5.19533231861999 0.9760194626853808 0.014870307344223344 1.3490991348015346 GOTERM_BP_ALL GO:0045927~positive regulation of growth 6 0.88% 0.003649740420906231 STAT5A, POU3F2, AKT1, TSHR, DLG1, ADRB2, 657 25 15360 5.610958904109588 0.9999999954621603 0.05688736220635926 6.755648622874322 GOTERM_BP_ALL GO:0048583~regulation of response to stimulus 8 1.18% 0.001170475034977267 STAT5A, TGM2, PRKCA, ELA2, TNFRSF1B, IL12A, LEP, ADRB2, 657 39 15360 4.795691371033836 0.9978734996222528 0.02303833966479385 2.215501630896355 GOTERM_BP_ALL GO:0051649~establishment of cellular localization 62 9.14% 1.265483526651501E-4 XPO1, KIF17, NOD2, HAP1, CALR, STAT1, KRT18, UPF1, NXF3, HGS, NPM1, DNAJC1, CCL8, ACHE, HSP90AA1, SET, SYK, MVP, SNPH, RPH3AL, PARK2, SCG5, CRYAB, CAMK4, CLTCL1, ADRB2, NOS1AP, LCP2, AKAP3, BCL2L1, WAS, CADM1, NLGN1, RPGR, SNCAIP, PIGR, PEX14, YWHAB, CCL5, PTPN11, MYH4, STX12, GSK3B, MYRIP, STX1A, TP53, RYR1, RAB3B, TUBB, F2, AKT1, KIF5A, TUBA1A, ROPN1B, SNAP25, PICK1, APBB1, TUBA8, AP2M1, SMAD3, RAB27A, AKAP5, 657 881 15360 1.6452868523211999 0.4856889899043363 0.003270144439030065 0.2418075792842922 GOTERM_BP_ALL GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 12 1.77% 5.679032263806668E-4 EBI3, C1QA, IL18, MBL2, CADM1, LY9, RYR1, IL4, CR2, CD46, IL12A, IL27RA, 657 80 15360 3.506849315068493 0.9494408386641017 0.012514332119982763 1.0808156500051957 GOTERM_BP_ALL GO:0010324~membrane invagination 20 2.95% 7.930253378359816E-4 APLP1, SYNJ1, SLC9A3, VAV1, ELA2, SH3GL2, PICALM, RYR1, ELMO1, CAP1, APP, LRP1, LRP2, PTX3, RAC1, DNM2, EHD2, CBL, CLTCL1, ADRB2, 657 197 15360 2.373502074496442 0.9845200260066281 0.01634015807409195 1.5061891085153212 GOTERM_BP_ALL GO:0002449~lymphocyte mediated immunity 11 1.62% 0.0011470149571511852 C1QA, MBL2, CADM1, LY9, RYR1, TUBB, IL4, CR2, CD46, IL12A, IL27RA, 657 74 15360 3.4752560779958035 0.997594206338302 0.02283814071868373 2.1715563647286995 GOTERM_BP_ALL GO:0051641~cellular localization 64 9.44% 8.668035240986418E-5 XPO1, KIF17, NOD2, HAP1, CALR, STAT1, KRT18, UPF1, NXF3, HGS, EGFR, NPM1, DNAJC1, CCL8, ACHE, HSP90AA1, SET, SYK, MVP, SNPH, RPH3AL, PARK2, SCG5, CRYAB, CAMK4, CLTCL1, ADRB2, NOS1AP, LCP2, AKAP3, BCL2L1, WAS, CADM1, NLGN1, RPGR, SNCAIP, PIGR, PEX14, YWHAB, CCL5, PTPN11, MYH4, STX12, GSK3B, MYRIP, STX1A, TP53, RYR1, RAB3B, TUBB, F2, AKT1, KIF5A, TUBA1A, ROPN1B, SNAP25, PICK1, APBB1, CD2, TUBA8, AP2M1, SMAD3, RAB27A, AKAP5, 657 906 15360 1.6514963661838378 0.3658300564011161 0.002406825451026884 0.16568797738261143 GOTERM_BP_ALL GO:0002443~leukocyte mediated immunity 12 1.77% 5.679032263806668E-4 C1QA, MBL2, CADM1, LY9, RYR1, TUBB, IL4, CR2, CD46, IL12A, IL27RA, SYK, 657 80 15360 3.506849315068493 0.9494408386641017 0.012514332119982763 1.0808156500051957 GOTERM_BP_ALL GO:0008544~epidermis development 15 2.21% 0.0044178545483097836 WAS, RELA, PPARA, AKT1, FGF7, SOX9, EDA2R, GLI1, NGFR, POU3F2, NOTCH1, TGM1, PSEN2, KRT17, S100A7, 657 148 15360 2.3694927804516843 0.9999999999210993 0.06613192028057502 8.121223505898323 GOTERM_BP_ALL GO:0031032~actomyosin structure organization and biogenesis 5 0.74% 0.0030867255251772266 ACTA1, CNN1, MYOZ1, TTN, ACTB, 657 15 15360 7.792998477929984 0.9999999117186763 0.049341548474610364 5.742511983752008 GOTERM_BP_ALL GO:0045893~positive regulation of transcription, DNA-dependent 37 5.46% 5.980353980719983E-10 CTNNB1, POU2F1, TLX1, CITED2, FHL2, REL, NEUROD1, NRIP1, E2F1, PPARG, HMGA1, NR5A1, NCOA1, YEATS4, PPARGC1A, TP53, JUN, PPARA, RELA, SOX9, TFAP2B, HAND1, HAND2, CRX, FOXH1, FOXO1, APP, STAT5A, GLI1, SMAD3, NOTCH1, SOX10, IL4, EP300, NCOA2, TCF4, ADRB2, 657 263 15360 3.2890601941073316 3.142073050854677E-6 5.067867592245534E-8 1.1440326797007572E-6 GOTERM_BP_ALL GO:0045892~negative regulation of transcription, DNA-dependent 24 3.54% 4.8672256847649124E-5 CBX2, CTNNB1, IRF8, ZBTB16, SOX9, HAND1, TWIST1, NR0B1, NRIP1, STAT3, ORC2L, E2F1, ID2, HMGB1, PEX14, PPARG, SMAD3, HDAC4, RYBP, ZNF238, ZEB1, PAWR, TCF4, NCOA2, 657 215 15360 2.6097483274928317 0.2256491867715702 0.0014437605080989124 0.09306822270963577 GOTERM_BP_ALL GO:0008361~regulation of cell size 19 2.80% 0.0019842856879896354 FGFR1, YEATS4, PML, TP53, ITCH, NDN, ERBB2IP, NPPB, FHL1, IGFBP5, IGFBP1, APBB1, SMAD3, PRKCQ, NPR1, IGFBP3, AR, SHC1, NEDD9, 657 197 15360 2.25482697077162 0.9999706375593954 0.0344133585285592 3.728397474679779 GOTERM_BP_ALL GO:0002376~immune system process 93 13.72% 5.101106630123429E-9 CD28, CXCL2, OPRD1, INPPL1, TAL1, NOD2, POU2AF1, IL27RA, PRL, FCGR3A, TNFRSF25, SH2D1A, PTX3, FYN, MBL2, LY9, RAG1, CRKL, S100A7, CIITA, CXCL3, CCL8, ZAP70, CASP3, HCLS1, ELA2, ZBTB16, CCR1, PIK3R1, KLF1, IL12A, SYK, SLAMF1, EBI3, IL4R, INPP5D, ID2, CCR4, IL18, PRKCQ, NOTCH1, ADD2, ZEB1, GZMA, LMO2, IL18R1, EPB42, CTNNB1, LCP2, CD5, CCL7, PRKCA, RFX1, C1QA, TLX1, WAS, CADM1, VAV1, HLA-DRA, CD46, PSMB9, IFI16, CD244, ITGB2, ERBB2, PAX5, CCL5, IL16, NTRK1, LEP, CCL2, RAG2, FCGR2B, CTSG, IRF8, C1QBP, TUBB, RYR1, AKT1, RELA, NCK1, LCK, CXCL1, STAT5A, CD2, C5AR1, SMAD3, HDAC4, CEBPB, KIR3DL1, IL4, CR2, MMP9, 657 1165 15360 1.8663060732553352 2.6800855248643174E-5 3.8842332161781457E-7 9.758339503118663E-6 GOTERM_BP_ALL GO:0048534~hemopoietic or lymphoid organ development 29 4.28% 5.75313804460882E-8 EPB42, CTNNB1, TAL1, TLX1, IFI16, PRL, ERBB2, RAG1, CRKL, LEP, NTRK1, RAG2, ZAP70, IRF8, HCLS1, RYR1, PIK3R1, ZBTB16, KLF1, SYK, LCK, STAT5A, CD2, ID2, HDAC4, ADD2, IL4, MMP9, LMO2, 657 206 15360 3.2912178037859645 3.022242025750854E-4 3.4348791180249805E-6 1.1005660427443331E-4 GOTERM_BP_ALL GO:0045859~regulation of protein kinase activity 25 3.69% 5.020426438067593E-5 CCNA1, PTEN, PRKCA, CAV3, APC, PDE6G, ERBB2, PTPN11, EGFR, CDKN3, SHC1, CASP3, CCNT1, ELA2, ADRA2A, CDC6, SYK, RGS4, ERN1, PICK1, CAV1, C5AR1, C13orf15, GNB2L1, ADRB2, 657 230 15360 2.541195155846734 0.23185735434183696 0.0014643702428410732 0.09599630427185035 GOTERM_BP_ALL GO:0048523~negative regulation of cellular process 127 18.73% 2.1935535108267077E-24 PRKCZ, HSF1, RAP1A, CAV3, PTPN6, NR0B1, PLG, MMP14, KRT18, HSPB1, HMGB1, FOXO4, RYBP, CDKN3, WNT2, TGM2, ZBTB17, RGS19, NF2, RGS4, ADRBK1, LRP1, ID2, NOTCH1, ZNF238, IGFBP3, PDZD3, ADRB2, FURIN, RGS2, ABI1, USH2A, NRIP1, ORC2L, CTBP1, GSK3B, CASP2, CCL2, ADAMTS1, JUN, AKT1, CDC6, ITGB1BP3, SOX9, HDAC1, DLG1, CXCL1, STAT5A, CAV1, SMAD3, CDH5, NPR1, IL4, MAPK8, EPHB2, TCF4, CD28, SPTA1, PTEN, POU2F1, MAPK1, PROX1, IAPP, RUNX3, FZD1, PPARG, HGS, GPX1, EGFR, NPM1, PAWR, FGFBP1, CBX2, DNAJC1, PML, CASP3, ELA2, SET, PIK3R1, NDN, ZBTB16, ERN1, NPPB, PAK7, ZEB1, CRYAB, LMO2, ADCYAP1, CTNNB1, PIM1, CXXC4, PRKCA, BCL2L1, CDC2, KNG1, CADM1, CBLC, TWIST1, MYF6, STAT3, E2F1, APC, PEX14, SFRP1, MYC, BCL2L10, TIE1, IRF8, TP53, DAPK1, STARD13, MAGED1, RELA, SIX3, HAND1, FOXO1, APBB1, CDC7, RAC1, NME1, HDAC4, CEBPB, RTN4, NOS3, WT1, MAPK8IP2, NCOA2, 657 1132 15360 2.6229084983138904 1.1524930145883522E-20 6.779370674049131E-22 4.196234729041361E-21 GOTERM_BP_ALL GO:0048522~positive regulation of cellular process 116 17.11% 1.5473130913096274E-23 NOD2, FHL2, PLG, TNFRSF25, PTX3, FOXO4, HMGA1, PRKCG, WNT2, TGM2, ADRA2A, PPARA, SYK, IL12A, NF2, EBI3, FOXH1, ID2, BTK, TRAF3, NOTCH1, IGFBP3, HCFC1, ADRB2, CD5, IGF1, VAV1, FGF7, IFI16, NRIP1, PRKCE, ERBB2, DNM2, PRTN3, GSK3B, LEP, CD38, TUBB, JUN, SOX9, TFAP2B, STAT5A, CD2, SMAD3, IL4, MMP9, TCF4, CD28, FGFR1, PTEN, POU2F1, MAPK1, CREBBP, REL, NEUROD1, EDA2R, PRL, RUNX3, DDR2, PDE6G, BTC, PPARG, EGFR, GPX1, PAWR, NR5A1, PML, CASP3, PPARGC1A, HCLS1, ELA2, ZBTB16, CASP1, ABL1, TSHR, ERN1, SLAMF1, APP, GLI1, IL18, PRKCQ, HBEGF, EP300, CTNNB1, PRKCA, CADM1, KNG1, TLX1, CITED2, MYF6, E2F1, NGFR, SHC1, MYC, GRN, NCOA1, YEATS4, TP53, RYR1, DAPK1, RELA, HIVEP3, NCK1, HAND1, HAND2, LCK, CRX, FOXO1, MX1, CDC7, POU3F2, NME1, CEBPB, SOX10, CBL, NCOA2, 657 996 15360 2.722854889879151 8.129582981740783E-20 4.5164349898559904E-21 2.959986569010921E-20 GOTERM_BP_ALL GO:0042981~regulation of apoptosis 78 11.50% 2.4397275678665473E-21 CD28, PRKCZ, PTEN, MAPK1, NOD2, CALR, CASP9, STAT1, PLG, TNFRSF25, RUNX3, KRT18, HSPB1, HMGB1, GPX1, NPM1, PAWR, SEPT4, PML, TGM2, CASP3, ZBTB16, PIK3R1, CASP1, ABL1, IL12A, ERN1, PAK7, BTK, TRAF3, IL18, CRYAB, IGFBP3, ADRB2, ACTN2, CD5, PIM1, PRKCA, BCL2L1, CDC2, CADM1, KNG1, ACTN3, IFI16, PRKCE, APAF1, NGFR, DNM2, SFRP1, GSK3B, CASP2, CCL2, BCL2L10, CD38, TP53, TUBB, CTSB, F2, DAPK1, MAGED1, AKT1, TRAF1, RELA, SOX9, HDAC1, LCK, FOXO1, MX1, STAT5A, CD2, SMAD3, NME1, CEBPB, IL4, RTN4, MAPK8, MAPK8IP2, MMP9, 657 538 15360 3.389519784081071 1.2818328641570839E-17 6.103966019795639E-19 4.667161981301674E-18 GOTERM_BP_ALL GO:0048519~negative regulation of biological process 134 19.76% 2.811236475562606E-26 PRKCZ, HSF1, RAP1A, CAV3, PTPN6, NR0B1, PLG, MMP14, KRT18, HSPB1, HMGB1, SPP1, FOXO4, RYBP, CDKN3, PRKCG, WNT2, TGM2, ZBTB17, RGS19, NF2, RGS4, ADRBK1, LRP1, ID2, NOTCH1, ZNF238, IGFBP3, PDZD3, ADRB2, FURIN, RGS2, ABI1, USH2A, NRIP1, ORC2L, CTBP1, GSK3B, CASP2, LEP, CCL2, ADAMTS1, JUN, F2, AKT1, CDC6, ITGB1BP3, SOX9, HDAC1, DLG1, CXCL1, STAT5A, CAV1, SMAD3, CDH5, NPR1, IL4, MAPK8, EPHB2, TCF4, CD28, SPTA1, PTEN, POU2F1, MAPK1, PROX1, IL27RA, IAPP, RUNX3, FZD1, PPARG, HGS, GPX1, EGFR, NPM1, PAWR, FGFBP1, CBX2, DNAJC1, PML, CASP3, ELA2, SET, PIK3R1, NDN, ZBTB16, ERN1, NPPB, PAK7, ZEB1, CRYAB, LMO2, ADCYAP1, CTNNB1, PIM1, CXXC4, PRKCA, BCL2L1, CDC2, KNG1, CADM1, CBLC, TWIST1, MYF6, STAT3, E2F1, APC, NGFR, PEX14, SFRP1, MYC, BCL2L10, TIE1, IRF8, TP53, DAPK1, STARD13, MAGED1, RELA, SIX3, HAND1, FOXO1, APBB1, CDC7, RAC1, HDAC4, NME1, PLN, CEBPB, RTN4, WT1, NOS3, MAPK8IP2, NCOA2, 657 1181 15360 2.6526548587026704 1.477023644260593E-22 1.0550168887575665E-23 5.377852909481899E-23 GOTERM_BP_ALL GO:0048518~positive regulation of biological process 127 18.73% 2.636683697225665E-25 NOD2, FHL2, PLG, TNFRSF25, PTX3, FYN, FOXO4, HMGA1, PRKCG, WNT2, TGM2, ADRA2A, PPARA, SYK, IL12A, NF2, EBI3, FOXH1, ID2, BTK, TRAF3, NOTCH1, IGFBP3, HCFC1, ADRB2, CD5, IGF1, VAV1, FGF7, IFI16, NRIP1, PRKCE, ERBB2, DNM2, PRTN3, GSK3B, LEP, CD38, TUBB, JUN, AKT1, SOX9, TFAP2B, DLG1, STAT5A, CD2, CAV1, SMAD3, IL4, MMP9, TCF4, CD28, FGFR1, PTEN, POU2F1, MAPK1, IL27RA, CREBBP, REL, NEUROD1, EDA2R, PRL, RUNX3, DDR2, PDE6G, BTC, PPARG, MBL2, EGFR, GPX1, PAWR, NR5A1, ACHE, PML, PPARGC1A, CASP3, HSP90AA1, HCLS1, ELA2, ZBTB16, CASP1, ABL1, TSHR, ERN1, SLAMF1, APP, GLI1, IL18, PRKCQ, HBEGF, EP300, CTNNB1, PRKCA, C1QA, CADM1, KNG1, TLX1, CITED2, CD46, MYF6, E2F1, NGFR, SHC1, MYC, GRN, NCOA1, YEATS4, TP53, RYR1, DAPK1, RELA, HIVEP3, NCK1, HAND1, HAND2, LCK, CRX, FOXO1, MX1, CDC7, POU3F2, NME1, CEBPB, SOX10, CR2, CBL, NCOA2, 657 1106 15360 2.6845681917643076 1.3853136145223642E-21 9.235424096815761E-23 5.04393608142509E-22 GOTERM_BP_ALL GO:0048514~blood vessel morphogenesis 21 3.10% 2.7673083500935168E-5 TIE1, CTNNB1, FGFR1, PML, TGM2, PTEN, CEACAM1, ANGPT1, FGF1, HAND1, CSPG4, HAND2, NPPB, PLG, ERBB2, MMP14, IL18, FOXO4, NPR1, THBS1, S100A7, 657 166 15360 2.9575837596963193 0.13532052729394495 8.916046921303433E-4 0.05292491301008839 GOTERM_BP_ALL GO:0048513~organ development 144 21.24% 6.393356034971409E-28 CAV3, YY1, FHL3, NR0B1, PLG, MMP14, COL1A2, SPP1, FYN, FOXO4, EMX2, MYOZ1, RAG1, S100A7, ALK, WNT2, TGM2, NPR3, PPARA, TTN, KLF1, BMX, SYK, FOXH1, ADRBK1, ID2, BTK, NOTCH1, KRT17, IGFBP3, ADRB2, TBR1, IGF1, USH2A, FGF7, ANGPT1, CASQ2, DVL1, IFI16, NRIP1, FHL1, ERBB2, APAF1, AR, ERBB3, LEP, CCL2, ADAMTS1, AKT1, ITGB1BP3, SOX9, ACTB, TFAP2B, FGF1, AES, STAT5A, PAX3, CD2, SGCG, SMAD3, CDH5, TGM1, NPR1, PSEN2, IL4, IKZF1, MMP9, FGFR1, GNAQ, PTEN, MAPK1, PROX1, TAL1, LHX3, DCN, EDA2R, NEUROD1, PRL, MYF5, ROR2, EGFR, NR5A1, CRKL, THBS1, ACHE, PML, ZAP70, CASP3, ANKRD2, HCLS1, PIK3R1, ZBTB16, CSPG4, NPPB, APP, LRP2, GLI1, IL18, HBEGF, ADD2, CRYAB, EP300, CD44, LMO2, EPB42, CTNNB1, APLP1, WAS, TLX1, CITED2, CEACAM1, TWIST1, MYF6, E2F1, SALL1, NGFR, PAX5, EN1, PKP2, CHAT, NTRK1, RAG2, PRKG1, TIE1, ACTA1, IRF8, HCK, FGD1, RYR1, RELA, HOXD10, SIX3, HAND1, HAND2, CRX, LCK, FOXO1, POU3F2, HDAC4, PLN, CEBPB, ASCL1, NOS3, HTN1, 657 1282 15360 2.6260338084756265 3.3590692607739786E-24 2.7992243839783153E-25 1.2230393512926995E-24 GOTERM_BP_ALL GO:0033238~regulation of amine metabolic process 11 1.62% 1.1326158647187472E-4 PRKCE, PRKCA, HCLS1, EGFR, JUN, IL4, IGFBP3, IL12A, SYK, NF2, ITGB2, 657 56 15360 4.592302674494455 0.4484981454272816 0.0029860358023496847 0.2164453933152788 GOTERM_BP_ALL GO:0008286~insulin receptor signaling pathway 7 1.03% 0.003864481905643171 FOXO1, PRKCA, SNF1LK2, FOXO4, PIK3R1, AKT1, IRS1, 657 36 15360 4.545915778792491 0.9999999985377968 0.05858003189181593 7.139346768465571 GOTERM_BP_ALL GO:0008285~negative regulation of cell proliferation 31 4.57% 1.5666444226712798E-7 HSF1, PTEN, PROX1, ABI1, PTPN6, APC, PLG, CTBP1, RUNX3, HGS, FOXO4, NPM1, CDKN3, PAWR, FGFBP1, ADAMTS1, WNT2, CASP3, TP53, NDN, ZBTB16, MAGED1, CDC6, NF2, CXCL1, CAV1, CDC7, CDH5, NME1, HDAC4, NOS3, 657 242 15360 2.9948299935846636 8.227763781006869E-4 8.66433135249256E-6 2.9969628585480024E-4 GOTERM_BP_ALL GO:0008284~positive regulation of cell proliferation 34 5.01% 2.794983889031533E-9 CD28, FGFR1, IGF1, TLX1, FGF7, PRL, DDR2, ERBB2, BTC, EGFR, PRTN3, SHC1, MYC, GRN, TGM2, HCLS1, ELA2, ADRA2A, NCK1, TSHR, SYK, IL12A, EBI3, SLAMF1, STAT5A, GLI1, CDC7, POU3F2, IL18, PRKCQ, NME1, IL4, HBEGF, ADRB2, 657 240 15360 3.3120243531202433 1.4684737666970094E-5 2.1917677428540117E-7 5.346761866587002E-6 GOTERM_BP_ALL GO:0008283~cell proliferation 93 13.72% 6.9418643854265765E-19 CD28, HSF1, FGFR1, PTEN, FGF8, PROX1, LMO1, TAL1, PTPN6, PRL, RUNX3, PLG, DDR2, MMP14, CDK3, BTC, PDZK1, HGS, FOXO4, GPX1, EGFR, NPM1, CDKN3, PAWR, FGFBP1, WNT2, ACHE, TGM2, CASP3, HCLS1, ELA2, ZBTB16, NDN, ADRA2A, TSHR, IL12A, SYK, NF2, SLAMF1, EBI3, LRP1, LRP2, GLI1, IL18, PRKCQ, NOTCH1, GNAI2, HBEGF, ZEB1, AREG, ADRB2, FES, CTNNB1, CD5, PIM1, IGF1, TLX1, CADM1, ABI1, FGF7, IFI16, E2F1, APC, CTBP1, ERBB2, PRTN3, AR, SHC1, MYC, GRN, ADAMTS1, TP53, RYR1, MAGED1, NCK1, CDC6, SOX9, FGF1, DLG1, CSF1R, FOXO1, CXCL1, STAT5A, CAV1, POU3F2, CDC7, CDH5, SMAD3, HDAC4, NME1, ASCL1, IL4, NOS3, 657 796 15360 2.731465546912645 3.647255548103123E-15 1.2576743269321116E-16 1.3279681701242816E-15 GOTERM_BP_ALL GO:0048489~synaptic vesicle transport 6 0.88% 0.0016098037801608104 SNPH, SNAP25, CTNNB1, SYNJ1, DNM2, NLGN1, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0008219~cell death 97 14.31% 1.4506338951791332E-19 PRKCZ, NOD2, PTPN6, CASP9, STAT1, PLG, TNFRSF25, KRT18, HSPB1, HMGB1, RYBP, PRKCG, TGM2, IL12A, ELMO1, BTK, TRAF3, IGFBP3, GZMA, ADRB2, CD5, IFI16, ITGB2, PRKCE, APAF1, DNM2, GSK3B, CASP2, CD38, CCL2, AGTR2, TUBB, F2, CTSB, AKT1, SOX9, HDAC1, STAT5A, PAX3, CD2, SMAD3, TNFRSF1B, IL4, PSEN2, MAPK8, MMP9, CD28, MAPK1, PTEN, CALR, IAPP, RUNX3, GPX1, NPM1, PAWR, SEPT4, PML, CASP3, PIK3R1, ZBTB16, CASP1, ABL1, ERN1, INPP5D, APP, PAK7, IL18, CRYAB, EP300, ACTN2, SIAH2, PIM1, APLP1, BCL2L1, PRKCA, CDC2, KNG1, CADM1, ACTN3, PAK1, E2F1, NGFR, SFRP1, BCL2L10, TP53, RYR1, DAPK1, RELA, TRAF1, MAGED1, LCK, FOXO1, MX1, NME1, CEBPB, RTN4, MAPK8IP2, 657 834 15360 2.7191397566878 7.621630485271166E-16 2.822826105655987E-17 2.775040727308757E-16 GOTERM_BP_ALL GO:0030900~forebrain development 11 1.62% 9.668219556751633E-5 E2F1, PRKG1, CTNNB1, LRP2, GLI1, APAF1, APLP1, POU3F2, FYN, EMX2, ASCL1, 657 55 15360 4.675799086757991 0.39829790372264395 0.002615094321631317 0.18478957435779098 GOTERM_BP_ALL GO:0019226~transmission of nerve impulse 33 4.87% 3.8907267474950654E-5 POU3F1, CTNNB1, NOS1AP, DLGAP2, GNAQ, MAPK1, NLGN1, SNCAIP, HAP1, SLC6A4, NOS1, PLP1, ERBB2, SLC5A7, KCNK3, CHAT, PNOC, SNCB, DLG4, ACHE, WNT2, STX1A, NTSR1, SHC3, KIF5A, BSN, SNPH, SNAP25, PARK2, ACCN1, CAMK4, AKAP5, HOMER1, 657 348 15360 2.2169737049283578 0.18488230090799262 0.0011809365963793006 0.07440277027669362 GOTERM_BP_ALL GO:0019222~regulation of metabolic process 176 25.96% 1.9629734477835885E-6 HSF1, ASF1B, NOD2, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, UPF1, HMGB2, HSPB1, HMGB1, PTX3, FOXO4, EMX2, POU5F1, RYBP, HMGA1, PRKCG, CIITA, SATB1, ZBTB17, PPARA, KLF1, IL12A, SYK, NF2, EBI3, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, IGFBP3, HCFC1, EYA1, GCM1, PDZD3, ADRB2, TBR1, RFX1, FURIN, IFI16, CAND2, ITGB2, NRIP1, PRKCE, IKZF2, ORC2L, DNM2, AR, LEP, CCNT1, JUN, AKT1, CDC6, REN, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, CAV1, SMAD3, TNFRSF1B, IL4, HOXA10, IKZF1, TCF4, CD28, POU3F1, SPTA1, RUNX1T1, POU2F1, PROX1, TAL1, LHX3, MLLT10, CALR, CREBBP, REL, EDA2R, NEUROD1, RUNX3, MYF5, FZD1, PPARG, HGS, EGFR, NPM1, PAWR, NR5A1, RXRG, CBX2, DNAJC1, TAF1, PML, PPARGC1A, HSP90AA1, HCLS1, ELA2, SET, ZBTB16, NDN, ABL1, ERN1, HOXA9, APP, GLI1, PRKCQ, NHLH1, CAMK2A, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, APLP1, PRKCA, CITED1, TLX1, CITED2, PIAS3, MYF6, TWIST1, STAT3, E2F1, APC, SALL1, PAX5, HOXB2, PEX14, EN1, HABP4, NFE2, MYC, NCOA1, MLLT1, YEATS4, IRF8, STAR, MEIS1, TP53, MAPKAPK2, RYR1, MAGED1, RELA, HIVEP3, NCK1, HOXD10, SIX3, HAND1, HAND2, SMAD7, NR5A2, CRX, FOXO1, APBB1, POU3F2, HDAC4, CNOT3, CEBPB, ASCL1, PAX2, SOX10, WT1, IKZF4, NCOA2, 657 2975 15360 1.3830935113771534 0.010260471124816317 8.120514848830584E-5 0.003755071732769455 GOTERM_BP_ALL GO:0002252~immune effector process 15 2.21% 3.2199179336083936E-4 RAG2, C1QA, CADM1, TUBB, RYR1, RELA, CD46, SYK, IL27RA, IL12A, PTX3, MBL2, LY9, IL4, CR2, 657 113 15360 3.103406473511941 0.8158523329246514 0.007525191574600298 0.6141708385580813 GOTERM_BP_ALL GO:0019220~regulation of phosphate metabolic process 11 1.62% 0.001724952356194418 PRKCE, PRKCA, HCLS1, EGFR, JUN, IL4, IGFBP3, IL12A, SYK, NF2, ITGB2, 657 78 15360 3.2970378175857626 0.9998850168790746 0.03069007387487943 3.2487148361198925 GOTERM_BP_ALL GO:0002250~adaptive immune response 12 1.77% 5.679032263806668E-4 EBI3, C1QA, IL18, MBL2, CADM1, LY9, RYR1, IL4, CR2, CD46, IL12A, IL27RA, 657 80 15360 3.506849315068493 0.9494408386641017 0.012514332119982763 1.0808156500051957 GOTERM_BP_ALL GO:0019219~regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 150 22.12% 1.7738218701485978E-4 HSF1, ASF1B, NOD2, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, HMGB2, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, PRKCG, CIITA, SATB1, ZBTB17, PPARA, KLF1, NF2, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, HCFC1, EYA1, GCM1, PDZD3, ADRB2, TBR1, RFX1, CAND2, IFI16, NRIP1, IKZF2, ORC2L, DNM2, AR, CCNT1, JUN, CDC6, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, SMAD3, TNFRSF1B, IL4, HOXA10, IKZF1, TCF4, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, LHX3, MLLT10, CALR, CREBBP, REL, EDA2R, NEUROD1, RUNX3, MYF5, FZD1, PPARG, NPM1, PAWR, NR5A1, RXRG, CBX2, TAF1, PML, PPARGC1A, HCLS1, SET, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, PRKCQ, NHLH1, CAMK2A, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, CITED1, TLX1, CITED2, PIAS3, TWIST1, MYF6, STAT3, E2F1, SALL1, PEX14, HOXB2, PAX5, EN1, HABP4, NFE2, MYC, NCOA1, MLLT1, YEATS4, IRF8, MEIS1, TP53, MAPKAPK2, RYR1, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, HAND2, SMAD7, NR5A2, CRX, FOXO1, APBB1, POU3F2, HDAC4, CNOT3, CEBPB, ASCL1, PAX2, SOX10, WT1, IKZF4, NCOA2, 657 2658 15360 1.319356401455415 0.6062537754909896 0.004366255456124124 0.3387843694956705 GOTERM_BP_ALL GO:0030866~cortical actin cytoskeleton organization and biogenesis 5 0.74% 3.497744157271315E-4 EPB41L3, LLGL1, CALR, EHD2, DLG1, 657 9 15360 12.988330796549974 0.8408703894288441 0.008099921165792612 0.6669958616823624 GOTERM_BP_ALL GO:0030865~cortical cytoskeleton organization and biogenesis 6 0.88% 5.21629967687484E-5 EPB41L3, LLGL1, SYNPO, CALR, EHD2, DLG1, 657 11 15360 12.752179327521793 0.23972231184236004 0.0015130615326394148 0.09973985420679288 GOTERM_BP_ALL GO:0048469~cell maturation 15 2.21% 2.541384782221091E-7 EPB42, CTNNB1, FGFR1, ACTA1, GNAQ, NLGN1, PLP1, KLF1, TTN, REN, ACTB, APP, PICK1, MYOZ1, SOX10, 657 62 15360 5.656208572691117 0.001334352693170171 1.3352348201212116E-5 4.8616194975314997E-4 GOTERM_BP_ALL GO:0051480~cytosolic calcium ion homeostasis 11 1.62% 5.837893735235572E-4 GNA15, LCK, TRPC6, CNTNAP1, OPRL1, TGM2, C5AR1, CCR4, KNG1, CCR1, CCR3, 657 68 15360 3.7818963201719042 0.9534917249914686 0.012598172741019265 1.1108898982029713 GOTERM_BP_ALL GO:0048468~cell development 140 20.65% 3.869207277124712E-27 PRKCZ, NOD2, PTPN6, CASP9, STAT1, PLG, TNFRSF25, MMP14, KRT18, HSPB1, HMGB1, FYN, EMX2, MYOZ1, RYBP, PRKCG, RAG1, WNT2, TGM2, TTN, KLF1, IL12A, ELMO1, NF2, BTK, TRAF3, NOTCH1, GZMA, IGFBP3, GCM1, ADRB2, CD5, IGF1, NLGN1, PLP1, IFI16, ITGB2, PRKCE, APAF1, PTPN11, DNM2, GSK3B, CASP2, CCL2, CD38, AGTR2, TUBB, CASC5, CTSB, F2, AKT1, REN, ITGB1BP3, SOX9, ACTB, PTPRZ1, HDAC1, STAT5A, PICK1, PAX3, CD2, SMAD3, TNFRSF1B, PSEN2, IL4, MAPK8, S100A4, MMP9, CD28, FGFR1, GNAQ, PTEN, MAPK1, CALR, IAPP, PRL, RUNX3, GPX1, NPM1, PAWR, SEPT4, ACHE, PML, CASP3, PIK3R1, NDN, ZBTB16, CASP1, ABL1, ERN1, INPP5D, APP, PAK7, CCR4, IL18, CRYAB, EP300, ACTN2, EPB42, CTNNB1, SIAH2, PIM1, APLP1, PRKCA, BCL2L1, CDC2, CADM1, KNG1, TLX1, ACTN3, TWIST1, PAK1, E2F1, NGFR, EN1, SFRP1, CHAT, NFASC, BCL2L10, PRKG1, ACTA1, TP53, RYR1, DAPK1, MAGED1, RELA, TRAF1, LCK, FOXO1, MX1, APBB1, POU3F2, CDC7, NME1, CEBPB, ASCL1, PAX2, SOX10, RTN4, MAPK8IP2, 657 1245 15360 2.628963341952284 2.032881503401324E-23 1.5637550026164028E-24 7.401735070511777E-24 GOTERM_BP_ALL GO:0045786~negative regulation of progression through cell cycle 22 3.24% 2.4681517814560385E-4 RAP1A, PML, PTEN, CASP3, TP53, CADM1, ZBTB17, STARD13, DLG1, NF2, ERN1, APC, RUNX3, APBB1, FOXO4, NME1, EGFR, CDKN3, WT1, EPHB2, MYC, ADCYAP1, 657 209 15360 2.4609468877673635 0.7266294295169721 0.005877780600483162 0.47109881626047345 GOTERM_BP_ALL GO:0045765~regulation of angiogenesis 8 1.18% 0.0013673244447606698 NPPB, TIE1, PLG, ERBB2, PML, FOXO4, NPR1, THBS1, 657 40 15360 4.675799086757991 0.9992450344892198 0.026178326932702056 2.5835022965231325 GOTERM_BP_ALL GO:0032989~cellular structure morphogenesis 43 6.34% 2.1789221238019005E-5 ACTN2, SPTA1, EPB42, CTNNB1, FGFR1, PTEN, ITCH, LLGL1, ITGB2, FHL1, IGFBP5, CAP1, NGFR, FYN, WNT1, PTPN11, CHAT, AR, SHC1, NFASC, PRKG1, YEATS4, PML, FGD1, TP53, NDN, NCK1, ERBB2IP, DLG1, AKAP2, PTPRZ1, NPPB, IGFBP1, APBB1, POU3F2, RAC1, SMAD3, PRKCQ, NPR1, PAX2, RTN4, IGFBP3, NEDD9, 657 499 15360 2.01462285301196 0.10817184439046867 7.335885846867507E-4 0.04167421907149693 GOTERM_BP_ALL GO:0008016~regulation of heart contraction 10 1.47% 1.1928477273624513E-4 SCN5A, ADRBK1, S100A1, RYR2, PRKCA, SP4, PLN, HBEGF, SLC8A1, ADRB2, 657 46 15360 5.082390311693468 0.4656795776581816 0.003113350298629247 0.227943392720098 GOTERM_BP_ALL GO:0008015~blood circulation 24 3.54% 6.920105120643202E-7 RYR2, WNT2, AGTR2, PRKCA, KNG1, NPR3, REN, SLC8A1, MEOX2, NPPB, ADRBK1, SCN5A, S100A1, GUCY1B3, SP4, CAV1, HOXB2, NFE2, PLN, NPR1, GPX1, HBEGF, NTS, ADRB2, 657 167 15360 3.3598556312033465 0.003629222881997962 3.1615365342685386E-5 0.0013237973515045631 GOTERM_BP_ALL GO:0045727~positive regulation of translation 9 1.33% 0.002187672161174612 CD28, EBI3, STAT5A, ELA2, PRKCQ, IL4, RELA, SYK, REL, 657 55 15360 3.8256537982565377 0.9999899367510243 0.03714333967914607 4.103018654040547 GOTERM_BP_ALL GO:0032963~collagen metabolic process 6 0.88% 0.0020109110481224633 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 22 15360 6.376089663760896 0.9999744778505163 0.034752869493891336 3.777517980199796 GOTERM_BP_ALL GO:0007626~locomotory behavior 27 3.98% 3.4087856977116015E-7 CXCL2, CCL7, OPRD1, MAPK1, PRKCA, CCR3, SERPIND1, ITGB2, CCL5, CHAT, MAPK14, IL16, CXCL3, CCL2, CCL8, NTSR1, ELA2, CCR1, IL8RA, TSHR, SYK, CXCL1, CNTNAP1, C5AR1, CCR4, TRH, IL4, 657 198 15360 3.188044831880448 0.0017893734700166197 1.755843713380223E-5 6.520935395437633E-4 GOTERM_BP_ALL GO:0051345~positive regulation of hydrolase activity 13 1.92% 3.1415030178090194E-5 BCL2L10, GNA15, GNAQ, TP53, F2, LCK, CASP9, ERN1, STAT1, APAF1, C5AR1, SMAD3, EGFR, 657 69 15360 4.404738270134339 0.15215476115465132 9.878779617443767E-4 0.060079367258336625 GOTERM_BP_ALL GO:0051338~regulation of transferase activity 26 3.83% 3.878326378714855E-5 CCNA1, PTEN, PRKCA, CAV3, APC, PDE6G, ERBB2, PTPN11, EGFR, CDKN3, SHC1, CASP3, CCNT1, ELA2, ADRA2A, CDC6, SYK, RGS4, ERN1, PICK1, CAV1, C5AR1, C13orf15, GNB2L1, IRS1, ADRB2, 657 241 15360 2.5222152750146836 0.18435104551569603 0.0011840148925634786 0.07416572010199296 GOTERM_BP_ALL GO:0002026~regulation of the force of heart contraction 4 0.59% 0.003696174872552823 ADRBK1, PRKCA, PLN, SLC8A1, 657 8 15360 11.689497716894977 0.9999999964477363 0.05742124909427648 6.838744387954765 GOTERM_BP_ALL GO:0032946~positive regulation of mononuclear cell proliferation 9 1.33% 7.178012379703285E-5 CD28, EBI3, STAT5A, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 34 15360 6.1885576148267525 0.31418427267180293 0.002036552091140287 0.1372249812224724 GOTERM_BP_ALL GO:0032944~regulation of mononuclear cell proliferation 11 1.62% 2.3290950348140595E-5 CD28, EBI3, STAT5A, ERBB2, CASP3, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 47 15360 5.471679782376372 0.11518091465958602 7.791363041933508E-4 0.04454583044102289 GOTERM_BP_ALL GO:0032943~mononuclear cell proliferation 13 1.92% 3.6464512657869886E-5 CD28, CASP3, CADM1, RYR1, NCK1, SYK, IL12A, EBI3, STAT5A, ERBB2, IL18, PRKCQ, IL4, 657 70 15360 4.341813437703848 0.17435307020236146 0.0011263536729020363 0.06973300892875178 GOTERM_BP_ALL GO:0007610~behavior 39 5.75% 2.2365322485935452E-8 CXCL2, OPRD1, CCL7, PRKCA, MAPK1, CCR3, SERPIND1, ITGB2, FYN, CCL5, CHAT, MAPK14, CRHBP, PRKCG, IL16, LEP, DLG4, CCL2, CXCL3, CCL8, DDO, AGTR2, NTSR1, ELA2, SHC3, CCR1, IL8RA, REN, TSHR, SYK, CXCL1, APP, CNTNAP1, PARK2, C5AR1, CCR4, TRH, IL4, NOS3, 657 328 15360 2.779819579017708 1.1750050191439154E-4 1.526069038693123E-6 4.2784515374982846E-5 GOTERM_BP_ALL GO:0007601~visual perception 19 2.80% 0.004587748431881774 RBP4, RPGRIP1, TRPC3, RHO, RPGR, USH2A, OPN1LW, SIX3, CRX, PDE6G, PDC, BFSP2, EN1, GRK1, PAX2, BEST1, CRYAB, SAG, GJA3, 657 213 15360 2.085450296910841 0.9999999999678141 0.06801246185516052 8.420695151499347 GOTERM_BP_ALL GO:0051318~G1 phase 6 0.88% 0.002480345618033856 TAF1, E2F1, CDC2, CDC7, FOXO4, CDC6, 657 23 15360 6.098868374032161 0.9999978454404829 0.040829719099886086 4.639675422574941 GOTERM_BP_ALL GO:0042692~muscle cell differentiation 9 1.33% 0.0013285528944500977 PLG, ACTA1, FOXO4, MYOZ1, NOTCH1, IGFBP3, TTN, ITGB1BP3, ACTB, 657 51 15360 4.125705076551168 0.999074205075847 0.025538086334800147 2.5111246760811223 GOTERM_BP_ALL GO:0030574~collagen catabolic process 6 0.88% 0.0016098037801608104 MMP13, MMP1, MMP8, PRTN3, MMP7, MMP9, 657 21 15360 6.679712981082844 0.9997892260156729 0.029778766507645438 3.0350019023808072 GOTERM_BP_ALL GO:0018212~peptidyl-tyrosine modification 15 2.21% 1.308705493995197E-7 DYRK1A, PRKCA, HCLS1, ABI1, F2, ABL1, SYK, IL12A, NF2, ITGB2, PRKCE, STAT1, FYN, EGFR, IL4, 657 59 15360 5.943812398421175 6.873575730047543E-4 7.314802092706074E-6 2.5035308698351244E-4 GOTERM_BP_ALL GO:0042592~homeostatic process 45 6.64% 3.149230365269134E-8 TRPC6, GNA15, CTNNB1, CCL7, PRKCA, BCL2L1, CAV3, KNG1, CCR3, USH2A, CALR, KCNA5, CREBBP, IAPP, PLG, CCL5, GRK1, GPX1, SLC2A4, MYC, CCL2, RYR2, OPRL1, TGM2, PPARGC1A, CASP3, SLC9A3, ELA2, SLC9A3R1, RYR1, CCR1, AKT1, NR5A2, NPPB, LCK, APP, CNTNAP1, STAT5A, C5AR1, CAV1, CCR4, PLN, NPR1, EP300, ADRB2, 657 418 15360 2.516877498852985 1.654468781575602E-4 2.094435351041035E-6 6.024428395035031E-5 GOTERM_BP_ALL GO:0001944~vasculature development 26 3.83% 6.085875662563746E-7 FGFR1, CTNNB1, PTEN, PROX1, CEACAM1, ANGPT1, PLG, MMP14, ERBB2, FOXO4, CRKL, THBS1, S100A7, TIE1, PML, TGM2, AKT1, FGF1, HAND1, CSPG4, HAND2, NPPB, FOXO1, CDH5, IL18, NPR1, 657 191 15360 3.1824810538143393 0.0031924134230338908 2.880607199773344E-5 0.0011642123977639862 GOTERM_BP_ALL GO:0018193~peptidyl-amino acid modification 20 2.95% 1.2569855965002395E-6 DYRK1A, TGM2, PRKCA, HCLS1, ABI1, F2, AKT1, ABL1, IL12A, SYK, CREBBP, NF2, ITGB2, PRKCE, STAT1, FYN, EGFR, IL4, GSK3B, EP300, 657 124 15360 3.7708057151274113 0.006582446631635985 5.457872932612684E-5 0.0024045670584005308 GOTERM_BP_ALL GO:0006521~regulation of amino acid metabolic process 11 1.62% 1.1326158647187472E-4 PRKCE, PRKCA, HCLS1, EGFR, JUN, IL4, IGFBP3, IL12A, SYK, NF2, ITGB2, 657 56 15360 4.592302674494455 0.4484981454272816 0.0029860358023496847 0.2164453933152788 GOTERM_BP_ALL GO:0051251~positive regulation of lymphocyte activation 12 1.77% 2.4336077688601312E-5 CD28, EBI3, LCK, STAT5A, ZAP70, CD5, IL18, PRKCQ, IL4, NCK1, IL12A, SYK, 657 57 15360 4.921893775534727 0.12002634374150412 8.038484891601527E-4 0.04654428025688828 GOTERM_BP_ALL GO:0001932~regulation of protein amino acid phosphorylation 11 1.62% 9.668219556751633E-5 PRKCE, PRKCA, HCLS1, EGFR, JUN, IL4, IGFBP3, IL12A, SYK, NF2, ITGB2, 657 55 15360 4.675799086757991 0.39829790372264395 0.002615094321631317 0.18478957435779098 GOTERM_BP_ALL GO:0051249~regulation of lymphocyte activation 16 2.36% 1.9983779527627878E-6 CD28, CD5, ZAP70, CASP3, NCK1, SYK, IL27RA, IL12A, LCK, EBI3, STAT5A, CD2, ERBB2, IL18, PRKCQ, IL4, 657 83 15360 4.50679430048963 0.0104445610320828 8.202388784839254E-5 0.003822797583952209 GOTERM_BP_ALL GO:0045596~negative regulation of cell differentiation 12 1.77% 2.8551491478824164E-4 CTNNB1, STAT5A, MAPK1, FOXO4, ZBTB16, NOTCH1, IL4, USH2A, ITGB1BP3, LMO2, TWIST1, IAPP, 657 74 15360 3.791188448722695 0.7769388997431518 0.00670526424533513 0.5447743986558562 GOTERM_BP_ALL GO:0007519~skeletal muscle development 15 2.21% 5.5565568237471255E-6 ACTA1, ITGB1BP3, TTN, ACTB, MYF6, APP, PLG, MYF5, MYOZ1, FOXO4, CHAT, NOTCH1, IGFBP3, EP300, ADRB2, 657 79 15360 4.439049765909485 0.02877219607381698 2.0413462086632528E-4 0.010629073869139471 GOTERM_BP_ALL GO:0045595~regulation of cell differentiation 21 3.10% 1.4635093490447127E-5 CTNNB1, GNAQ, MAPK1, NLGN1, ZBTB16, USH2A, ITGB1BP3, TWIST1, IAPP, CRX, STAT5A, ID2, POU3F2, PPARG, FOXO4, NOTCH1, ASCL1, IL4, IGFBP3, LEP, LMO2, 657 159 15360 3.0877918497458428 0.07401138929912177 5.124909241123188E-4 0.02799299885842821 GOTERM_BP_ALL GO:0051247~positive regulation of protein metabolic process 14 2.06% 1.5570479984606788E-4 CD28, PML, PPARGC1A, ELA2, HCLS1, RELA, NCK1, SYK, IL12A, REL, EBI3, STAT5A, PRKCQ, IL4, 657 93 15360 3.5194186674522507 0.5587469303084864 0.0038883099837355717 0.2974408869969136 GOTERM_BP_ALL GO:0051246~regulation of protein metabolic process 34 5.01% 1.0644141804683193E-6 CD28, SPTA1, APLP1, PRKCA, FURIN, REL, ITGB2, PRKCE, APC, UPF1, HSPB1, HGS, EGFR, PRKCG, DNAJC1, PML, PPARGC1A, HCLS1, ELA2, SET, RELA, AKT1, NCK1, REN, SYK, IL12A, NF2, EBI3, STAT5A, APBB1, PRKCQ, CEBPB, IL4, HCFC1, 657 307 15360 2.58920470602234 0.005576826525585776 4.6994148517609524E-5 0.0020361886006181606 GOTERM_BP_ALL GO:0007517~muscle development 30 4.42% 4.160765420037225E-10 PTEN, CAV3, IGF1, TWIST1, FHL3, MYF6, FHL1, PLG, NGFR, MYF5, MYOZ1, FOXO4, CHAT, ACTA1, ACHE, ANKRD2, ITGB1BP3, TTN, ACTB, APP, SGCG, SMAD3, HDAC4, NOTCH1, PLN, HBEGF, CRYAB, IGFBP3, EP300, ADRB2, 657 177 15360 3.9625415989474493 2.1860635766035585E-6 3.5837146361572536E-8 7.959480741170921E-7 GOTERM_BP_ALL GO:0051239~regulation of multicellular organismal process 45 6.64% 2.419627886066248E-13 CD28, CD5, PRKCA, C1QA, NOD2, CD46, SLC8A1, IL27RA, IAPP, SCN5A, ERBB2, SPP1, FYN, MBL2, CHAT, LEP, PRKG1, RYR2, TPM3, ACHE, ZAP70, CASP3, CNN1, NCK1, IL12A, SYK, NPPB, LCK, EBI3, ADRBK1, S100A1, STAT5A, PARK2, CD2, SP4, CAV1, IL18, SMAD3, PRKCQ, PLN, NPR1, HBEGF, IL4, CR2, ADRB2, 657 292 15360 3.6029273784950275 1.2710350549838267E-9 3.259059688787147E-11 4.6278536558475025E-10 GOTERM_BP_ALL GO:0018108~peptidyl-tyrosine phosphorylation 15 2.21% 8.19608537182714E-8 DYRK1A, PRKCA, HCLS1, ABI1, F2, ABL1, SYK, IL12A, NF2, ITGB2, PRKCE, STAT1, FYN, EGFR, IL4, 657 57 15360 6.152367219418409 4.3052963886358597E-4 4.784681257308243E-6 1.5678975862076783E-4 GOTERM_BP_ALL GO:0032774~RNA biosynthetic process 136 20.06% 0.0015163058145148938 HSF1, ASF1B, POU2AF1, YY1, FHL2, NR0B1, MEOX2, STAT1, YBX1, HMGB2, HMGB1, FOXO4, EMX2, POU5F1, RYBP, HMGA1, CIITA, SATB1, ZBTB17, PPARA, KLF1, FOXH1, POU3F3, FOS, ID2, HOXD4, SP4, NOTCH1, ZNF238, HCFC1, EYA1, GCM1, ADRB2, TBR1, RFX1, CAND2, IFI16, NRIP1, IKZF2, ORC2L, AR, CCNT1, JUN, KHDRBS2, SOX9, TFAP2B, HDAC1, HOXB7, AES, STAT5A, PAX3, SMAD3, IL4, HOXA10, IKZF1, TCF4, POU3F1, RUNX1T1, POU2F1, PROX1, TAL1, MLLT10, LHX3, CALR, CREBBP, REL, NEUROD1, RUNX3, MYF5, PPARG, PAWR, NR5A1, RXRG, CBX2, TAF1, PML, PPARGC1A, HCLS1, NDN, ZBTB16, ABL1, ERN1, HOXA9, APP, GLI1, NHLH1, ZEB1, EP300, HMGA2, CTNNB1, DLGAP2, CITED1, TLX1, CITED2, PIAS3, TWIST1, MYF6, STAT3, E2F1, SALL1, PEX14, HOXB2, PAX5, EN1, HABP4, NFE2, MYC, MLLT1, NCOA1, YEATS4, IRF8, COPS2, MEIS1, TP53, MAGED1, RELA, HIVEP3, HOXD10, SIX3, HAND1, SMAD7, HAND2, NR5A2, CRX, FOXO1, POU3F2, CNOT3, HDAC4, CEBPB, COPS5, ASCL1, SOX10, PAX2, WT1, IKZF4, NCOA2, 657 2490 15360 1.276925051805395 0.9996552588859285 0.028271502859907538 2.861142929828886 GOTERM_BP_ALL GO:0007507~heart development 20 2.95% 2.0543384817006408E-6 CTNNB1, GNAQ, PTEN, CASP3, CITED2, SOX9, CASQ2, HAND1, DVL1, HAND2, FOXH1, ADRBK1, ERBB2, ID2, PKP2, PLN, NOTCH1, CRKL, ERBB3, EP300, 657 128 15360 3.65296803652968 0.010735464598424116 8.366708474838447E-5 0.003929845297567791 GOTERM_BP_ALL GO:0009987~cellular process 611 90.12% 1.0761603165457566E-11 CXCL2, INCENP, XPO1, ITCH, NOD2, HAP1, PTPN6, PORCN, TNFRSF25, MMP14, SLC5A7, KRT18, FHOD1, CDK3, PTX3, HMGB1, PPP1R3A, FYN, MYOZ1, RAG1, PRKCG, MAPKBP1, NTSR1, ARRB2, SYK, ACCN3, CA8, NF2, IL4R, TNIK, ID2, BTK, FRS3, C13orf15, NTS, KSR1, SFRS9, GCM1, CLTCL1, TRPC6, MMP13, CD5, BFSP1, RGS2, VAV1, ABI1, RPGR, YTHDC1, NRIP1, ITGB2, PRKCE, CTBP1, FMNL1, YWHAB, RPA1, NDC80, CRHBP, ERBB3, MYRIP, RASIP1, PTPRT, FCGR2B, ADAMTS1, ITIH4, IRS4, RAB3B, TUBB, JUN, CTSB, F2, ITGB1BP3, KHDRBS2, PTPRZ1, FGF1, TXK, HOXB7, PICK1, PAX3, CD2, CAV1, MMP9, SLC8A2, ASIP, PKP3, INPPL1, PROX1, IL27RA, REL, EDA2R, IGFBP5, PDE6G, SH2D1A, BTC, ROR2, NR5A1, THBS1, SNCB, CBX2, EPB41L3, HSP90AA1, ELA2, AKAP2, NCF2, PAK7, HBEGF, EP300, AREG, EPB42, VIPR2, LCP2, DLGAP2, TRPC4, PIM1, WAS, CADM1, LIPE, KNG1, PIAS3, TWIST1, STAT3, PEX14, PKP2, HABP4, CHAT, SHC1, FGF13, GRN, PTPRN, PRKG1, DDO, YEATS4, OPRL1, IRF8, COPS2, STAR, RYR1, HOXD10, PSTPIP1, SHANK1, FOXO1, MAP3K8, CNOT3, HSPA8, CEBPB, AKAP13, F11R, RTN4, GNG13, AKAP5, MAPK8IP2, CBL, MYLK, PRKCZ, ASF1B, CAV3, EPHA7, SRC, GRAP, CD247, PLG, PTPRO, HMGB2, HSPB1, WNT1, EMX2, NEK2, KCNK3, RYBP, CDKN3, HMGA1, ALK, CIITA, CCL8, NPR3, BSN, SNPH, UBE2I, MYBPC1, FOS, NOTCH1, IGFBP3, EYA1, UCN, HSPG2, TBR1, ZYX, PPP2R5A, PTPRH, AKAP3, ANGPT1, PLP1, CAND2, IFI16, ORC2L, DOK3, PRTN3, AXL, PNOC, SYNPO, GSK3B, AR, CASP2, IL16, CDC6, TUBA1A, HDAC1, TUBA8, CDH5, SMAD3, SELE, NPR1, MAPK8, EPHB2, S100A4, IKZF1, IQGAP2, GNAQ, POU2F1, LHX3, MLLT10, CALR, NEUROD1, BFSP2, FZD1, PTPN21, GPX1, EGFR, CXCL3, SEPT4, ACHE, PML, ZAP70, PPARGC1A, CASP3, ROS1, SET, PIK3R1, NDN, DCX, IL8RA, KLRA1, TSHR, CSPG4, MVP, NPPB, INPP5D, CAMK2A, ZEB1, NEDD4, CCNA1, BCL2L1, CBLC, CITED2, CCR3, KISS1, PSMB9, PAK1, ITPR1, E2F1, RAG2, BCL2L10, TIE1, MLLT1, SNAP91, MAPKAPK2, CNN1, DAPK1, STARD13, KBTBD10, RELA, PLA2G2A, ITGB1, SIX3, HAND1, LCK, MX1, PLCG1, DSG2, CDC7, KIR3DL1, RAB27A, NCOA2, HSF1, PPIB, DARC, FGF8, LLGL1, POU2AF1, ACTL6B, OPN1LW, YY1, ANGPT4, ORC6L, FHL3, NR0B1, CASP9, PLCD1, STAT1, CAP1, UPF1, COL1A2, POU5F1, S100A7, TPM3, AURKC, ZBTB17, SLC9A3R1, PTPN7, ADRA2A, BMX, EBI3, FOXH1, ADRBK1, POU3F3, GNB2L1, WNT4, NEDD9, MS4A3, RHO, NLGN1, SLC6A4, USH2A, DOT1L, DVL1, HIST3H3, FHL1, CSNK2A1, DNMT3A, SOS1, PTPN11, CLSTN3, EXOSC4, LEP, CD38, CD84, AGTR2, MAPK10, SOX9, DLG1, AES, CXCL1, ACCN1, CD72, TNFRSF1B, MLLT4, IL4, HOXA10, MMP12, ABP1, TCF4, SPTA1, POU3F1, GNA15, DSC1, DSC3, MAPK1, LMO1, RUNX3, GUCY1B3, CBX5, NPHS1, LY9, CRKL, GJA3, FGFBP1, RXRG, SHC3, EPHB1, CCR1, ZBTB16, PPP1R9A, SLAMF1, SH3BP1, APP, GLI1, MOS, GUCY2C, SCG5, MMP8, CCR4, TRH, PRKCQ, CRYAB, LMO2, ADCYAP1, MAGI1, ACTN2, HMGA2, ACP1, SIAH2, APLP1, CCL7, CITED1, C1QA, CDC2, TLX1, HK3, PRKAR2A, MMP7, ACTN3, MYF6, FGR, PCSK1, SALL1, ERC2, PAX5, HOXB2, SFRP1, BLK, NTRK1, NFASC, CTSG, NCOA1, MMP1, HCK, MIS12, TRAF1, HAND2, IQGAP1, SMAD7, CRX, THBS2, CA9, POU3F2, RAC1, HDAC4, NME1, PLN, PAX2, SOX10, WT1, NOS3, IKZF4, HTN1, DYRK1A, RAP1A, KIF17, TRPC3, NOS1, SLC8A1, FHL2, MEOX2, YBX1, PDC, TEK, SPP1, PCSK2, GRK1, FOXO4, YWHAE, DLG4, MSN, WNT2, TGM2, SATB1, PPFIA1, PTK2, PPARA, TTN, KLF1, IL12A, RGS19, ELMO1, ITGB3, ACPP, RGS4, LRP1, S100A1, PARK2, PXN, HOXD4, SP4, TRAF3, SNF1LK2, ZNF238, GNAI2, CAMK4, GZMA, HCFC1, PRKACA, HOMER1, PDZD3, ADRB2, IL18R1, NOS1AP, RFX1, IGF1, CASK, FURIN, SNCAIP, FGF7, KCNA5, CD244, GRAP2, IKZF2, ERBB2, APAF1, DNM2, MAPK14, EHD2, CCL2, TTR, EXOSC1, RBMY1A1, CCNT1, TYROBP, PICALM, CASC5, AKT1, REN, ACTB, TFAP2B, SNAP25, STAT5A, SGCG, AP2M1, MPP3, TGM1, PSEN2, CD28, RUNX1T1, FGFR1, DSG3, OPRD1, PTEN, TAL1, TG, CREBBP, IAPP, PRL, DDR2, NXF3, PDZK1, MYF5, PPARG, MBL2, HGS, NPM1, PAWR, BAI2, DNAJC1, TAF1, GUCY1A2, HCLS1, CASP1, ABL1, ERBB2IP, VIM, SH2D3C, ERN1, HOXA9, LRP2, RPH3AL, MME, IL18, KIRREL, NHLH1, SAG, CD44, ARHGEF7, ICAM5, FES, CTNNB1, CXXC4, ANXA13, PRKCA, CNTN1, TEC, CEACAM1, SHC2, CD46, SLA, APC, NGFR, STAMBPL1, PIGR, CCL5, PPP1CA, EN1, MYH4, NFE2, STX12, MYC, RYR2, ACTA1, STX1A, SYNJ1, FGD1, MEIS1, SLC9A3, TP53, SH3GL2, MAGED1, PPFIA4, HIVEP3, NCK1, KIF5A, RPA4, CSF1R, NR5A2, ROPN1B, IGFBP1, CNTNAP1, APBB1, C5AR1, NID1, MAPK8IP1, COPS5, ASCL1, CR2, IRS1, 657 12970 15360 1.101354372401362 5.654151746803393E-8 1.177948294461828E-9 2.0586810034473046E-8 GOTERM_BP_ALL GO:0009968~negative regulation of signal transduction 16 2.36% 5.355819475189319E-5 CXXC4, PRKCA, PTEN, CAV3, RGS2, CBLC, SIX3, RGS19, NF2, ADRBK1, RGS4, LRP1, CAV1, HGS, IGFBP3, ADRB2, 657 108 15360 3.463554879079993 0.24527534453091315 0.0015365357554389947 0.10240629018818392 GOTERM_BP_ALL GO:0009966~regulation of signal transduction 45 6.64% 1.2225350285049856E-4 IQGAP2, CXXC4, PRKCA, PTEN, IGF1, CAV3, RGS2, VAV1, CBLC, NOD2, CITED2, REL, EDA2R, PDE6G, SOS1, HGS, GRK1, SHC1, TGM2, FGD1, HCLS1, CASP1, RELA, REN, IL12A, RGS19, SYK, SIX3, NF2, IQGAP1, RGS4, ADRBK1, LRP1, GLI1, CAV1, SNF1LK2, RAC1, SMAD3, MAPK8IP1, AKAP13, IL4, IGFBP3, MAPK8IP2, ARHGEF7, ADRB2, 657 573 15360 1.8360467618159648 0.4739500822625432 0.003174945059969958 0.23361010681857142 GOTERM_BP_ALL GO:0051179~localization 188 27.73% 4.97893782239354E-7 SLC2A2, KIF17, TRPC3, XPO1, PEX5, CAV3, NOD2, HAP1, SLC8A1, STAT1, CAP1, PLG, MMP14, SLC5A7, KRT18, UPF1, SLC22A11, HSPB1, PTX3, COL1A2, FYN, WNT1, KCNK3, S100A7, MSN, MAPKBP1, CCL8, TPM3, WNT2, SCN3A, ADRA2A, PPARA, IL12A, SYK, ACCN3, ELMO1, ITGB3, NF2, KCNJ15, SNPH, LRP1, PARK2, PXN, ZNF238, CAMK4, NGB, KCNA3, PDZD3, ADRB2, CLTCL1, TRPC6, HSPG2, NOS1AP, AKAP3, IGF1, VAV1, NLGN1, KCNJ6, SNCAIP, SLC6A4, RPGR, SLC17A1, KCNA5, ITGB2, YWHAB, PTPN11, DNM2, MAPK14, STAU1, GSK3B, AR, MYRIP, EHD2, IL16, TTR, PICALM, RAB3B, TUBB, F2, AKT1, ACTB, TUBA1A, KCNJ9, SNAP25, PICK1, CD2, TUBA8, AP2M1, CAV1, ACCN1, SMAD3, NPR1, MAPK8, MMP12, SLC8A2, RBP4, ABCB4, PTEN, KCNJ16, CALR, KCNB1, NXF3, PDZK1, NPHS1, SLC17A7, MBL2, HGS, SYT11, EGFR, NPM1, GJA3, CRKL, THBS1, DNAJC1, ACHE, HSP90AA1, ELA2, SET, NDN, ERBB2IP, VIM, SLC22A2, CSPG4, MVP, NPPB, APP, LRP2, RPH3AL, CCR4, SCG5, CRYAB, HBEGF, ATP1B2, CTNNB1, LCP2, APLP1, TRPC4, PRKCA, BCL2L1, C1QA, WAS, CADM1, KNG1, CEACAM1, TRPM2, TWIST1, SCN5A, STAT3, ITPR1, NGFR, PIGR, APBA2, PEX14, CCL5, EN1, MYH4, STX12, SLC2A4, BEST1, NFASC, PRKG1, TIE1, RYR2, SNAP91, STX1A, SYNJ1, ABCB1, STAR, SLC9A3, TP53, SH3GL2, RYR1, NCK1, ITGB1, KIF5A, ROPN1B, LCK, APBB1, CA9, RAC1, MAPK8IP1, PLN, RAB27A, ASCL1, F11R, NOS3, AKAP5, CBL, 657 3161 15360 1.3904622402886782 0.002612516007625687 2.399911186001802E-5 9.524589850595788E-4 GOTERM_BP_ALL GO:0006468~protein amino acid phosphorylation 92 13.57% 5.688835367890809E-22 PRKCZ, FGFR1, DYRK1A, MAPK1, EPHA7, SRC, STAT1, DDR2, CDK3, TEK, FYN, ROR2, GRK1, NEK2, EGFR, PRKCG, CRKL, ALK, TAF1, WNT2, ZAP70, AURKC, HCLS1, ROS1, EPHB1, PTK2, PIK3R1, ABL1, TTN, BMX, IL12A, SYK, NF2, ERN1, ADRBK1, PAK7, TNIK, GUCY2C, MOS, BTK, SNF1LK2, PRKCQ, CAMK2A, CAMK4, IGFBP3, PRKACA, KSR1, FES, PIM1, PRKCA, CASK, CDC2, TEC, LIPE, CBLC, ABI1, PRKAR2A, ITGB2, PAK1, FGR, PRKCE, CTBP1, ERBB2, CSNK2A1, AXL, MAPK14, GSK3B, ERBB3, BLK, NTRK1, CCL2, PRKG1, TIE1, MAPK10, CCNT1, HCK, MAPKAPK2, F2, JUN, DAPK1, AKT1, CSF1R, TXK, LCK, PICK1, MAP3K8, CDC7, NPR1, IL4, MAPK8, EPHB2, MYLK, 657 704 15360 3.0552096305520964 2.9889141022898314E-18 1.5731126854157008E-19 1.088265611972485E-18 GOTERM_BP_ALL GO:0051174~regulation of phosphorus metabolic process 11 1.62% 0.001724952356194418 PRKCE, PRKCA, HCLS1, EGFR, JUN, IL4, IGFBP3, IL12A, SYK, NF2, ITGB2, 657 78 15360 3.2970378175857626 0.9998850168790746 0.03069007387487943 3.2487148361198925 GOTERM_BP_ALL GO:0009952~anterior/posterior pattern formation 13 1.92% 3.1415030178090194E-5 YY1, MYF6, NEUROD1, FOXH1, MEOX2, APC, MYF5, ROR2, EMX2, SFRP1, EN1, EP300, CRKL, 657 69 15360 4.404738270134339 0.15215476115465132 9.878779617443767E-4 0.060079367258336625 GOTERM_BP_ALL GO:0006464~protein modification process 139 20.50% 2.7270027750794445E-12 PRKCZ, DYRK1A, EPHA7, SRC, ITCH, PTPN6, OPN1LW, STAT1, MMP14, PTPRO, CDK3, TEK, FYN, PCSK2, GRK1, NEK2, CDKN3, PRKCG, ALK, WNT2, TGM2, AURKC, SATB1, PTK2, PTPN7, TTN, BMX, IL12A, SYK, NF2, ADRBK1, UBE2I, PARK2, TNIK, BTK, SNF1LK2, CAMK4, IGFBP3, PRKACA, KSR1, PTPRH, CASK, RHO, FURIN, ABI1, CAND2, ITGB2, PRKCE, CTBP1, ERBB2, CSNK2A1, PTPN11, AXL, MAPK14, GSK3B, ERBB3, PTPRT, CCL2, MAPK10, CCNT1, JUN, F2, AKT1, HDAC1, PTPRZ1, TXK, PICK1, TGM1, NPR1, PSEN2, IL4, MAPK8, EPHB2, GNA15, FGFR1, GNAQ, PTEN, MAPK1, CREBBP, DDR2, PTPN21, ROR2, EGFR, CRKL, TAF1, PML, ZAP70, PPARGC1A, HCLS1, ROS1, SET, EPHB1, PIK3R1, ZBTB16, ABL1, ERN1, LRP2, PAK7, MOS, GUCY2C, SCG5, PRKCQ, CAMK2A, EP300, NEDD4, ACP1, FES, EPB42, SIAH2, PIM1, PRKCA, CDC2, TEC, LIPE, CBLC, PIAS3, PRKAR2A, PAK1, FGR, STAMBPL1, PPP1CA, BLK, NTRK1, PTPRN, PRKG1, TIE1, HCK, TP53, MAPKAPK2, RYR1, DAPK1, KBTBD10, CSF1R, LCK, MAP3K8, CDC7, NID1, CBL, MYLK, 657 1804 15360 1.8013749253308224 1.4327872333019798E-8 3.183971974962674E-10 5.216782561490163E-9