Assessment of Renal Fibrosis with Diffusion-weighted MR Imaging: Study with Murine Model of Unilateral Ureteral Obstruction1

© RSNA, 2010




 

Supplemental Figures

 

Figure E1a
a.
Figure E1b Figure E1c
b.c.

Figure E1:(a) Typical coronal T2-weighted images of the kidneys (2500/40) before UUO (day 0) and 3 and 7 days after UUO of the right kidney. Hydronephrosis on the UUO side is observed on day 3 and has deteriorated by day 7, while the contralateral side is consistent over time. (b, c) Graphs illustrate changes in volume of the (b) renal pelvis and (c) the parenchyma on UUO and contralateral sides (n = 5). All data are expressed as mean percentage changes relative to the baseline value ± standard deviations. P < .01 (**) and P < .001 (***) for comparisons of UUO and contralateral sides at unpaired two-tailed Student t testing.

 

Figure E2

Figure E2: Renal cortex specimens immunohistochemically stained for type 1 collagen before UUO (day 0) and 3 and 7 days after UUO. The stained area and cell density in the interstitial space increase over time, indicating the deposition of collagen (extracellular matrix). (Original magnification, ×400.) Bars = 100 μm.