Blood, Vol. 116, Issue 23, 5037-5044, December 2, 2010

Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis
Blood McEachron et al. 116: 5037

Supplemental materials for: McEachron et al

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• Figure S1. mFVIIa, FXa, and thrombin dose titration in 4T1 cells (JPG, 160 KB) -
  Serum starved confluent cell monolayers were incubated with the indicated concentrations of FXa and thrombin for 24 hours. Levels of uPA in cell culture supernatant of 4T1 cells treated with mFVIIa (A), FXa (C), and thrombin (E) were determined by ELISA. PAI-1 levels the in cell culture supernatant of 4T1 cells treated with mFVIIa (B), FXa (D), and thrombin (F) was measured by ELISA. Results are shown as mean ± SEM of at least five independent experiments. *P≤0.05 and **P≤0.001 (control versus protease treated).