Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site -- Laxton et al. 55 (7): 3105 Data Supplement - Supplemental material -- Antimicrobial Agents and Chemotherapy

Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site
Antimicrob. Agents Chemother. Laxton et al. 55: 3105

Supplemental material

Files in this Data Supplement:

Supplemental file 1 - Table S1, characteristics and properties of LNA ASOs used in primary screen of 9B replicon cells. Fig. S1, dose-response curves of 6 hits from the primary screen. Fig. S2, LC-MS/MS chromatograms showing the integrity of seq132 during mouse plasma extraction and kidney tissue extraction.
Zipped MS Word document, 317K.