Cyclopentenyl Cytosine Induces Senescence in Breast Cancer Cells through the Nucleolar Stress Response and Activation of p53

Data Supplement

Files in this Data Supplement:

• Supplemental Figures - Fig. 1: Induction of morphological changes in MCF-7 and MDA-MB cell lines by CPEC.

  Fig. 2: Differential effects of CPEC on cell cycle progression and BrdUincorporation in MCF-7 cells.

  Fig. 3: Differential effects of CPEC on cell cycle progression and BrdUincorporation in MDA-MB-231 cells.

  Fig. 4: Induction ofp53 and Mdm2 by Nutlin3 in MCF-7 cells.

  Fig. 5: Induction of DNA fragmentation by CPEC and effect of p53 depletion.

  Fig. 6: CPEC-induced translocation of TIF-IA and PAF53 to the nucleolarcap.