The 1000 Genomes Project Consortium Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK. Richard M. Durbin, John Burton, David M. Carter, Carol Churcher, Alison Coffey, Anthony Cox, Aarno Palotie, Michael Quail, Tom Skelly, James Stalker, Harold P. Swerdlow, Daniel Turner, Qasim Ayub, Senduran Balasubramaniam, Jeffrey C. Barrett, Yuan Chen, Donald F. Conrad, Petr Danecek, Min Hu, Ni Huang, Matt E. Hurles, Luke Jostins, Thomas M. Keane, Si Quang Le, Sarah Lindsay, Quan Long, Daniel G. MacArthur, Leopold Parts, Chris Tyler-Smith, Klaudia Walter, Yali Xue, Yujun Zhang, Allison Coffey & Carol Scott The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. Stacey B. Gabriel, Eric S. Lander, Eric S. Lander (Principal Investigator), David Altshuler, Lauren Ambrogio, Toby Bloom, Kristian Cibulskis, Tim J. Fennell, Stacey B. Gabriel (Co-Chair), David B. Jaffe, Erica Shefler, Carrie L. Sougnez, Mark J. Daly (Principal Investigator), Mark A. DePristo (Project Leader), Aaron D. Ball, Eric Banks, Kiran V. Garimella, Sharon R. Grossman, Robert E. Handsaker, Matt Hanna, Chris Hartl, Andrew M. Kernytsky, Joshua M. Korn, Heng Li, Jared R. Maguire, Steven A. McCarroll, Aaron McKenna, James C. Nemesh, Anthony A. Philippakis, Ryan E. Poplin, Manuel A. Rivas, Pardis C. Sabeti, Stephen F. Schaffner, Ilya A. Shlyakhter, Mark A. DePristo & Jane Wilkinson Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. David Altshuler Department of Genetics, Harvard Medical School, Cambridge, Massachusetts 02115, USA. David Altshuler & Steven A. McCarroll Center for Statistical Genetics and Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA. Yun Li (Project Leader), Paul Anderson, Tom Blackwell, Wei Chen, Jun Ding, Hyun Min Kang, Carlo Sidore, Matthew Snyder, Xiaowei Zhan, Sebastian Zöllner & Gonçalo R. Abecasis Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex CB10 1XL, UK. David R. Bentley, Niall Gormley, Sean Humphray, Zoya Kingsbury, Paula Kokko-Gonzales, Jennifer Stone, R. Keira Cheetham, Tony Cox, Michael Eberle, Terena James, Scott Kahn & Lisa Murray McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. Aravinda Chakravarti Center for Comparative and Population Genomics, Cornell University, Ithaca, New York 14850, USA. Andrew G. Clark & Jeremiah Degenhardt US National Institutes of Health, 1 Center Drive, Bethesda, Maryland 20892, USA. Francis S. Collins Life Technologies, Foster City, California 94404, USA. Francisco M. De La Vega, Fiona C. L. Hyland, Onur Sakarya & Yongming A. Sun Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. Peter Donnelly, Gil A. McVean, Adam Auton, Zamin Iqbal, Gerton Lunter, Jonathan L. Marchini & Simon Myers Pall Corporation, 25 Harbor Park Drive, Port Washington, New York 11050, USA. Michael Egholm European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK. Paul Flicek, Laura Clarke (Project Leader), Fiona Cunningham, Javier Herrero, Stephen Keenen, Eugene Kulesha, Rasko Leinonen, William M. McLaren, Rajesh Radhakrishnan, Richard E. Smith, Vadim Zalunin & Xiangqun Zheng-Bradley Human Genome Sequencing Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA. Richard A. Gibbs, David Deiros, Mike Metzker, Donna Muzny, Jeff Reid, David Wheeler, Matthew Bainbridge, Danny Challis, Aniko Sabo, Fuli Yu, Jin Yu, Cristian Coafra, Huyen Dinh, Christie Kovar, Sandy Lee & Lynne Nazareth Centre of Genomics and Policy, McGill University, Montréal, Québec H3A 1A4, Canada. Bartha M. Knoppers Max Planck Institute for Molecular Genetics, D-14195 Berlin-Dahlem, Germany. Hans Lehrach, Ralf Sudbrak (Project Leader), Tatiana A. Borodina, Alexey N. Davydov, Peter Marquardt, Florian Mertes, Wilfiried Nietfeld, Aleksey V. Soldatov, Bernd Timmermann, Marius Tolzmann, Marcus W. Albrecht, Vyacheslav S. Amstislavskiy, Ralf Herwig & Dimitri V. Parkhomchuk The Genome Center, Washington University School of Medicine, St Louis, Missouri 63108, USA. Elaine R. Mardis, Richard K. Wilson, David Dooling, Lucinda Fulton, Robert Fulton, George Weinstock, Ken Chen, Asif Chinwalla, Li Ding, Daniel C. Koboldt, Mike D. McLellan, John W. Wallis, Michael C. Wendl & Qunyuan Zhang Department of Statistics, University of Oxford, Oxford OX1 3TG, UK. Jonathan L. Marchini, Loukas Moutsianas, Simon Myers, Afidalina Tumian & Gil A. McVean Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA. Deborah A. Nickerson, Gozde Aksay & Jeffrey M. Kidd Wellcome Trust, Gibbs Building, 215 Euston Road, London NW1 2BE, UK. Alan J. Schafer & Audrey Duncanson US National Institutes of Health, National Center for Biotechnology Information, 45 Center Drive, Bethesda, Maryland 20892, USA. Stephen T. Sherry, Richa Agarwala, Hoda M. Khouri, Aleksandr O. Morgulis, Justin E. Paschall, Lon D. Phan, Kirill E. Rotmistrovsky, Robert D. Sanders, Martin F. Shumway & Chunlin Xiao BGI-Shenzhen, Shenzhen 518083, China. Jun Wang, Min Jian, Guoqing Li, Ruiqiang Li, Huiqing Liang, Geng Tian, Bo Wang, Jian Wang, Wei Wang, Huanming Yang, Xiuqing Zhang, Huisong Zheng, Jun Wang (Principal Investigator), Xiaodong Fang, Xiaosen Guo, Yingrui Li, Ruibang Luo, Shuaishuai Tai, Honglong Wu, Hancheng Zheng, Xiaole Zheng, Yan Zhou, Taosha Li & Yeyang Su Department of Biology, University of Copenhagen 2200, Denmark. Jun Wang & Ruiqiang Li Life Technologies, Beverly, Massachusetts 01915, USA. Kevin J. McKernan (Principal Investigator), Gina L. Costa, Jeffry K. Ichikawa, Clarence C. Lee, Yutao Fu, Jonathan M. Manning, Stephen F. McLaughlin, Heather E. Peckham & Eric F. Tsung Deep Sequencing Group, Biotechnology Center TU Dresden, Tatzberg 47/49, 01307 Dresden, Germany. Andreas Dahl Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel 24105, Germany. Philip Rosenstiel & Stefan Schreiber Roche Applied Science, 20 Commercial Street, Branford, Connecticut 06405, USA. Jason Affourtit, Dana Ashworth, Said Attiya, Melissa Bachorski, Eli Buglione, Adam Burke, Amanda Caprio, Christopher Celone, Shauna Clark, David Conners, Brian Desany, Lisa Gu, Lorri Guccione, Kalvin Kao, Andrew Kebbel, Jennifer Knowlton, Matthew Labrecque, Louise McDade, Craig Mealmaker, Melissa Minderman, Anne Nawrocki, Faheem Niazi, Kristen Pareja, Ravi Ramenani, David Riches, Wanmin Song, Cynthia Turcotte, Shally Wang, James Knight & Roger Winer Department of Medical Genetics, Institute of Molecular Medicine (FIMM) of the University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland. Aarno Palotie Agilent Technologies Inc., Santa Clara, California 95051, USA. Anniek De Witte & Shane Giles Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA. Gabor T. Marth (Principal Investigator), Erik P. Garrison, Amit Indap, Deniz Kural, Wan-Ping Lee, Wen Fung Leong, Chip Stewart, Alistair N. Ward & Jiantao Wu US National Institutes of Health, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA. Weichun Huang Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. Aaron R. Quinlan Illumina, San Diego, California 92121, USA. Michael P. Stromberg Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. Charles Lee (Principal Investigator), Ryan E. Mills, Xinghua Shi & David Altshuler Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington 98195, USA. Brian L. Browning Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. Sharon R. Grossman, Pardis C. Sabeti & Ilya A. Shlyakhter Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. Alkes Price Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. David N. Cooper (Principal Investigator), Edward V. Ball, Matthew Mort, Andrew D. Phillips & Peter D. Stenson Departments of Psychiatry and Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. Jonathan Sebat (Principal Investigator) Seaver Autism Center and Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA. Vladimir Makarov & Seungtai C. Yoon Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA. Kenny Ye Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA. Department of Genetics, Stanford University, Stanford, California 94305, USA. Carlos D. Bustamante (Co-Principal Investigator), Michael Snyder (Co-Principal Investigator), Fabian Grubert, Hugo Y. K. Lam, Alexander E. Urban, Mark Kaganovich, Jeffrey M. Kidd & Simon Gravel Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA. European Molecular Biology Laboratory, Genome Biology Research Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany. Adrian M. Stütz & Jan O. Korbel Molecular Epidemiology Section, Medical Statistics and Bioinformatics, Leiden University Medical Center, 2333 ZA, The Netherlands. Kai Ye Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA. Mark A. Batzer (Principal Investigator), Miriam K. Konkel & Jerilyn A. Walker The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, Arizona 85004, USA. David W. Craig (Principal Investigator), Steve M. Beckstrom-Sternberg, Alexis Christoforides, Ahmet A. Kurdoglu, John V. Pearson, Shripad A. Sinari & Waibhav D. Tembe Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA. David Haussler (Principal Investigator), Angie S. Hinrichs, Sol J. Katzman, Andrew Kern & Robert M. Kuhn Department of Human Genetics and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA. Molly Przeworski Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94158, USA. Ryan D. Hernandez Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA. Bryan Howie, Joanna L. Kelley & S. Cord Melton National Heart and Lung Institute, Imperial College London, London SW7 2, UK. William O. Cookson & Miriam F. Moffatt Centre Nationale de Génotypage, Evry 91000, France. Mark Lathrop Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA. Liming Liang Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. Paul Scheet Department of Pediatrics, Faculty of Medicine, University of Montréal, Ste. Justine Hospital Research Centre, Montréal, Québec H3T 1C5, Canada. Philip Awadalla (Principal Investigator) Department of Medicine, Centre Hospitalier de l’Université de Montréal Research Center, Université de Montréal, Montréal, Québec H2L 2W5, Canada. Ferran Casals, Youssef Idaghdour, Jonathan Keebler, Eric A. Stone & Martine Zilversmit Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA. Jinchuan Xing & Lynn Jorde Department of Genome Sciences, University of Washington School of Medicine and Howard Hughes Medical Institute, Seattle, Washington 98195, USA. Evan E. Eichler & Can Alkan Department of Computer Science, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada. Iman Hajirasouliha & Fereydoun Hormozdiari Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge CB2 1TN, UK. Cornelis A. Albers Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland. Emmanouil T. Dermitzakis & Stephen B. Montgomery Center for Genome Science, Korea National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Korea. Hanjun Jin Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA. Mark B. Gerstein (Co-Principal Investigator), Alexej Abyzov, Lukas Habegger, Rajini Haraksingh, Justin Jee, Jing Leng & Xinmeng Jasmine Mu Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA. Robert Bjornson, Jiang Du & Mark B. Gerstein (Principal Investigator) Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA. Suganthi Balasubramanian, Ekta Khurana & Zhengdong Zhang Department of Psychiatry and Behavioral Studies, Stanford University, Stanford, California 94305, USA. Alexander E. Urban Coriell Institute, 403 Haddon Avenue, Camden, New Jersey 08103, USA. Neda Gharani & Lorraine H. Toji Centre for Health, Law and Emerging Technologies, University of Oxford, Oxford OX3 7LF, UK. Jane S. Kaye Genetic Alliance, 436 Essex Road, London N1 3QP, UK. Alastair Kent Center for Medical Ethics and Health Policy, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA. Amy L. McGuire Department of Medical History and Bioethics, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA. Pilar N. Ossorio US National Institutes of Health, Center for Research on Genomics and Global Health, 12 South Drive, Bethesda, Maryland 20892, USA. Charles N. Rotimi US National Institutes of Health, National Human Genome Research Institute, 5635 Fishers Lane, Bethesda, Maryland 20892, USA. Lisa D. Brooks, Adam L. Felsenfeld, Jean E. McEwen, Nicholas C. Clemm, Mark S. Guyer & Jane L. Peterson The George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA. Assya Abdallah US Food and Drug Administration, 11400 Rockville Pike, Rockville, Maryland 20857, USA. Christopher R. Juenger US National Institutes of Health, National Human Genome Research Institute, 31 Center Drive, Bethesda, Maryland 20892, USA. Eric D. Green Department of Ecology and Evolutionary Biology, Rice University, Houston, Texas 77251, USA. Reed A. Cartwright