Mutations with COSMIC Hits																																																											
Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	chromosome_name	start	stop	reference	variant	type	gene_name	Transcript_Name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	Transcript_Annotation	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error comment	COSMIC_gene	COSMIC_chrom	COSMIC_start	COSMIC_stop	COSMIC_amino	COSMIC_nucleotide	COSMIC_status
FLG2	388698	genome.wustl.edu	36	1	150595558	150595558	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-1489-01A-01W-0549-09	TCGA-13-1489-10A-01W-0549-09	T	T	T	A	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	1	150595558	150595558	T	A	SNP	FLG2	NM_001014342	human	genbank	54_36p	-1	provisional	missense	c.1328	p.E443V	0	NULL	"PatternScan_S100_CABP,HMMPfam_Filaggrin,HMMPfam_S_100,PatternScan_EF_HAND_1,HMMPfam_efhand,HMMPfam_SVS_QK,superfamily_SSF47473"	-	no_errors	FLG2	1	150595560	150595560	p.F442L	c.1326C>G	Confirmed
PLA2G4A	5321	genome.wustl.edu	36	1	185186473	185186473	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-24-1469-01A-01W-0553-09	TCGA-24-1469-10A-01W-0553-09	C	C					Unknown	Unknown	Somatic	4	Capture		1	dbGAP	Illumina GAIIx	1	185186473	185186473	C	G	SNP	PLA2G4A	NM_024420	human	genbank	54_36p	1	reviewed	missense	c.1326	p.H442Q	0.96	"HMMSmart_SM00022,superfamily_FabD/lysophospholipase-like,HMMPfam_PLA2_B"	"superfamily_C2 domain (Calcium/lipid-binding domain CaLB),HMMSmart_SM00239,HMMPfam_C2,HMMSmart_SM00022,superfamily_FabD/lysophospholipase-like,HMMPfam_PLA2_B,PatternScan_PPASE,PatternScan_SUBTILASE_ASP"	-	no_errors	PLA2G4A	1	185186473	185186473	p.H442Q	c.1326C>G	Confirmed
OR2T34	127068	genome.wustl.edu	36	1	246804504	246804504	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-13-0903-01A-01W-0421-09	TCGA-13-0903-10A-01W-0421-09	G	G	G	T	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	1	246804504	246804504	G	T	SNP	OR2T34	NM_001001821	human	genbank	54_36p	-1	provisional	missense	c.178	p.L60I	0.96	"superfamily_SSF81321,HMMPfam_7tm_1"	"superfamily_SSF81321,HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1"	-	no_errors	OR2T34	1	246804502	246804502	p.L60L	c.180C>A	Confirmed
PTEN	5728	genome.wustl.edu	36	10	89701885	89701885	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-10-0930-01A-02W-0421-09	TCGA-10-0930-11A-01W-0977-09	G	G	G	T	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	10	89701885	89701885	G	T	SNP	PTEN	NM_000314	human	genbank	54_36p	1	reviewed	missense	c.523	p.V175L	1	"superfamily_(Phosphotyrosine protein) phosphatases II,HMMSmart_SM00404"	"superfamily_(Phosphotyrosine protein) phosphatases II,HMMSmart_SM00404,PatternScan_TYR_PHOSPHATASE_1,HMMPfam_DSPc,HMMPfam_PTEN_C2,superfamily_C2 domain (Calcium/lipid-binding domain CaLB)"	-	no_errors	PTEN	10	89701884	89701884	p.Y174*	c.522T>G	Confirmed
KRAS	3845	genome.wustl.edu	36	12	25289551	25289551	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1316-01A-01W-0494-09	TCGA-25-1316-10A-01W-0494-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	12	25289551	25289551	C	A	SNP	KRAS	NM_033360	human	genbank	54_36p	-1	reviewed	missense	c.35	p.G12V	1	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	-	no_errors	KRAS	12	25289551	25289551	p.G12D	c.35G>A	Previously Observed
FLT3	2322	genome.wustl.edu	36	13	27506122	27506122	+	Missense_Mutation	SNP	A	G	G	novel	Unknown	TCGA-09-0369-01A-01W-0372-09	TCGA-09-0369-10C-01W-0372-09	A	A	G	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	13	27506122	27506122	A	G	SNP	FLT3	NM_004119	human	genbank	54_36p	-1	reviewed	missense	c.1844	p.V615A	0.92	"superfamily_Kinase_like,HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc"	"superfamily_SSF48726,HMMPfam_ig,superfamily_Kinase_like,HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc,PatternScan_PROTEIN_KINASE_ATP,PatternScan_RECEPTOR_TYR_KIN_III,PatternScan_PROTEIN_KINASE_TYR"	-	no_errors	FLT3				p.614_615>EYDLKWEFPRENLEFGK	c.1837_1838ins51	Unknown
GPR132	29933	genome.wustl.edu	36	14	104589053	104589053	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0726-01A-01W-0372-09	TCGA-13-0726-10B-01W-0977-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	14	104589053	104589053	G	A	SNP	GPR132	NM_013345	human	genbank	54_36p	-1	reviewed	missense	c.466	p.R156W	0	"superfamily_Family A G protein-coupled receptor-like,HMMPfam_7tm_1"	"superfamily_Family A G protein-coupled receptor-like,HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1"	-	no_errors	GPR132	14	104589052	104589052	p.R156Q	c.467G>A	Confirmed
CHD8	57680	genome.wustl.edu	36	14	20943240	20943240	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0760-01A-01W-0372-09	TCGA-13-0760-10A-01W-0372-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	14	20943240	20943240	C	T	SNP	CHD8	NM_020920	human	genbank	54_36p	-1	validated	missense	c.2438	p.R813H	1	HMMPfam_SNF2_N	"HMMPfam_SNF2_N,HMMPfam_Chromo,HMMSmart_SM00298,HMMPfam_Helicase_C,HMMSmart_SM00490,HMMPfam_BRK,HMMSmart_SM00592,HMMSmart_SM00487,superfamily_Chromo domain-like,superfamily_P-loop containing nucleoside triphosphate hydrolases"	-	no_errors	CHD8	14	20943240	20943240	p.R1092H	c.3275G>A	Confirmed
RTN1	6252	genome.wustl.edu	36	14	59263426	59263426	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0804-01A-01W-0372-09	TCGA-13-0804-10A-01W-0372-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	14	59263426	59263426	C	T	SNP	RTN1	NM_021136	human	genbank	54_36p	-1	reviewed	missense	c.1729	p.A577T	0	NULL	"HMMPfam_Reticulon,PatternScan_HISTONE_H4"	-	no_errors	RTN1	14	59263427	59263427	p.G576G	c.1728C>T	Confirmed
DCC	1630	genome.wustl.edu	36	18	48937840	48937840	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-13-0791-01A-01W-0372-09	TCGA-13-0791-10A-01W-0372-09	C	C	C	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	18	48937840	48937840	C	G	SNP	DCC	NM_005215	human	genbank	54_36p	1	validated	missense	c.1378	p.Q460E	1	"HMMSmart_SM00409,superfamily_Fibronectin type III,HMMSmart_SM00060,HMMPfam_fn3"	"superfamily_Immunoglobulin,HMMSmart_SM00409,HMMSmart_SM00408,HMMPfam_ig,HMMPfam_I-set,superfamily_Fibronectin type III,HMMSmart_SM00060,HMMPfam_fn3,HMMPfam_Neogenin_C"	-	no_errors	DCC	18	48937844	48937844	p.T461I	c.1382C>T	Confirmed
SNRPA	6626	genome.wustl.edu	36	19	45957227	45957227	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-13-1499-01A-01W-0549-09	TCGA-13-1499-10A-01W-0549-09	A	A	A	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	19	45957227	45957227	A	G	SNP	SNRPA	NM_004596	human	genbank	54_36p	1	provisional	missense	c.298	p.T100A	1	superfamily_SSF54928	"superfamily_SSF54928,HMMSmart_RRM,HMMPfam_RRM_1"	-	no_errors	SNRPA	19	45957225	45957225	p.G99D	c.296G>A	Confirmed
MOCS3	27304	genome.wustl.edu	36	20	49008919	49008919	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0903-01A-01W-0421-09	TCGA-13-0903-10A-01W-0421-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	20	49008919	49008919	C	A	SNP	MOCS3	NM_014484	human	genbank	54_36p	1	reviewed	missense	c.133	p.P45T	0	NULL	"superfamily_MoeB,HMMPfam_ThiF,HMMPfam_MoeZ_MoeB,superfamily_Rhodanese-like,HMMPfam_Rhodanese,HMMSmart_RHOD"	-	no_errors	MOCS3	20	49008917	49008917	p.V44G	c.131T>G	Confirmed
SEMA5B	54437	genome.wustl.edu	36	3	124162677	124162677	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0760-01A-01W-0372-09	TCGA-13-0760-10A-01W-0372-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	124162677	124162677	C	A	SNP	SEMA5B	NM_001031702	human	genbank	54_36p	-1	validated	missense	c.124	p.G42C	0.1	NULL	"superfamily_Sema domain,HMMPfam_Sema,HMMSmart_SM00630,HMMPfam_PSI,HMMSmart_SM00423,superfamily_Plexin repeat,superfamily_TSP-1 type 1 repeat,HMMSmart_SM00209,HMMPfam_TSP_1"	-	no_errors	SEMA5B	3	124162677	124162677	p.G42S	c.124G>A	Confirmed
PIK3CA	5290	genome.wustl.edu	36	3	180411038	180411038	+	Silent	SNP	C	C	T	novel	Unknown	TCGA-13-0890-01A-01W-0421-09	TCGA-13-0890-10A-01W-0421-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	180411038	180411038	C	T	SNP	PIK3CA	NM_006218	human	genbank	54_36p	1	reviewed	silent	c.1530	p.H510	1	superfamily_ARM-type_fold	###############################################################################################################################################################################################################################################################	-	no_errors	PIK3CA	3	180411038	180411038	p.H510H	c.1530C>T	Unknown
PIK3CA	5290	genome.wustl.edu	36	3	180418785	180418785	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0800-01A-01W-0372-09	TCGA-13-0800-10A-01W-0372-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	180418785	180418785	G	A	SNP	PIK3CA	NM_006218	human	genbank	54_36p	1	reviewed	missense	c.1633	p.E545K	1	"HMMPfam_PI3Ka,HMMSmart_PI3Ka,superfamily_ARM-type_fold"	###############################################################################################################################################################################################################################################################	-	no_errors	PIK3CA	3	180418785	180418785	p.E545K	c.1633G>A	Previously Observed
PIK3CA	5290	genome.wustl.edu	36	3	180434779	180434779	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-1416-01A-01W-0549-09	TCGA-24-1416-10A-01W-0549-09	A	A	A	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	180434779	180434779	A	G	SNP	PIK3CA	NM_006218	human	genbank	54_36p	1	reviewed	missense	c.3140	p.H1047R	1	"HMMSmart_PI3Kc,superfamily_Kinase_like"	###############################################################################################################################################################################################################################################################	-	no_errors	PIK3CA	3	180434779	180434779	p.H1047R	c.3140A>G	Confirmed
TCTEX1D2	255758	genome.wustl.edu	36	3	197502604	197502604	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-1488-01A-01W-0549-09	TCGA-13-1488-10A-01W-0549-09	G	G	G	C	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	197502604	197502604	G	C	SNP	TCTEX1D2	NM_152773	human	genbank	54_36p	-1	provisional	missense	c.420	p.F140L	1	HMMPfam_Tctex-1	HMMPfam_Tctex-1	-	no_errors	TCTEX1D2	3	197502604	197502604	p.F140L	c.420C>G	Confirmed
NEK10	152110	genome.wustl.edu	36	3	27179022	27179022	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-13-0791-01A-01W-0372-09	TCGA-13-0791-10A-01W-0372-09	C	C	C	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	27179022	27179022	C	G	SNP	NEK10	ENST00000396636	human	ensembl	54_36p	-1	known	missense	c.1135	p.E379Q	0.98	NULL	"HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMSmart_SM00219,HMMPfam_Pkinase,PatternScan_PROTEIN_KINASE_TYR"	-	no_errors	NEK10	3	27318224	27318224	p.E379K	c.1135G>A	Confirmed
FBXW7	55294	genome.wustl.edu	36	4	153466739	153466739	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-1316-01A-01W-0494-09	TCGA-25-1316-10A-01W-0494-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	4	153466739	153466739	G	A	SNP	FBXW7	NM_033632	human	genbank	54_36p	-1	reviewed	missense	c.1513	p.R505C	1	"superfamily_WD40 repeat-like,HMMSmart_SM00320,HMMPfam_WD40"	"superfamily_WD40 repeat-like,superfamily_F-box domain,HMMPfam_F-box,HMMSmart_SM00256,HMMSmart_SM00320,HMMPfam_WD40,PatternScan_WD_REPEATS_1"	-	no_errors	FBXW7	4	153466739	153466739	p.R505C	c.1513C>T	Previously Observed
SNX25	83891	genome.wustl.edu	36	4	186504684	186504684	+	Splice_Site	SNP	G	G	A	novel	Unknown	TCGA-24-1464-01A-01W-0549-09	TCGA-24-1464-10A-01W-0549-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	4	186504684	186504684	G	A	SNP	SNX25	NM_031953	human	genbank	54_36p	1	validated	splice_site	c.1696-1	e12-1	1	-	-	-	no_errors	SNX25	4	186504687	186504687	p.C566C	c.1698C>T	Confirmed
CSN3	1448	genome.wustl.edu	36	4	71149395	71149395	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-0369-01A-01W-0372-09	TCGA-09-0369-10C-01W-0372-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	4	71149395	71149395	C	A	SNP	CSN3	NM_005212	human	genbank	54_36p	1	validated	missense	c.179	p.T60N	0	HMMPfam_Casein_kappa	HMMPfam_Casein_kappa	-	no_errors	CSN3	4	71149398	71149398	p.N61S	c.182A>G	Confirmed
APC	324	genome.wustl.edu	36	5	112202549	112202549	+	Missense_Mutation	SNP	G	G	A	rs28933379	Unknown	TCGA-23-1022-01A-02W-0488-09	TCGA-23-1022-10A-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	5	112202549	112202549	G	A	SNP	APC	NM_000038	human	genbank	54_36p	1	reviewed	missense	c.3359	p.G1120E	1	NULL	"superfamily_ARM repeat,HMMSmart_SM00185,HMMPfam_Arm,HMMPfam_APC_15aa,HMMPfam_APC_crr,HMMPfam_SAMP,HMMPfam_APC_basic,HMMPfam_EB1_binding"	-	no_errors	APC	5	112202549	112202549	p.G1120E	c.3359G>A	Confirmed
BRAF	673	genome.wustl.edu	36	7	140095638	140095638	+	Nonsense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-04-1347-01A-01W-0488-09	TCGA-04-1347-11A-01W-0489-09	G	G	G	C	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	7	140095638	140095638	G	C	SNP	BRAF	NM_004333	human	genbank	54_36p	-1	reviewed	nonsense	c.1910	p.S637*	1	"superfamily_Protein kinase-like (PK-like),HMMSmart_SM00219,HMMPfam_Pkinase,HMMSmart_SM00220"	###############################################################################################################################################################################################################################################################	-	no_errors	BRAF	7	140095642	140095642	p.Q636E	c.1906C>G	Confirmed
COL1A2	1278	genome.wustl.edu	36	7	93892885	93892885	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-23-1022-01A-02W-0488-09	TCGA-23-1022-10A-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	7	93892885	93892885	G	A	SNP	COL1A2	NM_000089	human	genbank	54_36p	1	reviewed	missense	c.2809	p.G937S	1	HMMPfam_Collagen	"HMMPfam_Collagen,HMMSmart_SM00038,HMMPfam_COLFI"	-	no_errors	COL1A2	7	93892889	93892889	p.R938H	c.2813G>A	Confirmed
PTCH1	5727	genome.wustl.edu	36	9	97260321	97260321	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-13-1404-01A-01W-0494-09	TCGA-13-1404-10A-01W-0495-09	A	A	A	T	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	9	97260321	97260321	A	T	SNP	PTCH1	NM_000264	human	genbank	54_36p	-1	reviewed	missense	c.2963	p.V988E	1	"HMMPfam_Patched,superfamily_SSF82866"	"HMMPfam_Patched,superfamily_SSF82866"	-	no_errors	PTCH1	9	97260319	97260319	p.E989*	c.2965G>T	Confirmed
IRS4	8471	genome.wustl.edu	36	X	107863319	107863319	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-1315-01A-01W-0494-09	TCGA-25-1315-10A-01W-0494-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	X	107863319	107863319	G	A	SNP	IRS4	NM_003604	human	genbank	54_36p	-1	reviewed	missense	c.2912	p.P971L	0.06	NULL	"superfamily_SSF50729,HMMPfam_PH,HMMSmart_PH,HMMPfam_IRS,HMMSmart_PTBI"	-	no_errors	IRS4	23	107863315	107863316	p.A972>V	c.2915_2916CA>TT	Confirmed
GLRA2	2742	genome.wustl.edu	36	X	14537180	14537180	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-1403-01A-01W-0494-09	TCGA-13-1403-10A-01W-0495-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	X	14537180	14537180	G	A	SNP	GLRA2	NM_002063	human	genbank	54_36p	1	validated	missense	c.862	p.A288T	1	"superfamily_Neurotransmitter-gated ion-channel transmembrane pore,HMMPfam_Neur_chan_memb"	"superfamily_Nicotinic receptor ligand binding domain-like,HMMPfam_Neur_chan_LBD,PatternScan_NEUROTR_ION_CHANNEL,superfamily_Neurotransmitter-gated ion-channel transmembrane pore,HMMPfam_Neur_chan_memb"	-	no_errors	GLRA2	23	14537180	14537180	p.A288S	c.862G>T	Confirmed
MAGEA1	4100	genome.wustl.edu	36	X	152135372	152135372	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-0885-01A-02W-0421-09	TCGA-13-0885-10A-01W-0421-09	T	T	T	A	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	X	152135372	152135372	T	A	SNP	MAGEA1	NM_004988	human	genbank	54_36p	-1	reviewed	missense	c.833	p.K278I	0	HMMPfam_MAGE	HMMPfam_MAGE	-	no_errors	MAGEA1	23	152135372	152135372	p.K278T	c.833A>C	Confirmed
CACNA1F	778	hgsc.bcm.edu	36	X	48971729	48971729	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-0906-01A-01W-0419-10	TCGA-13-0906-10A-01W-0419-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	X	48971729	48971729	G	C	SNP	CACNA1F	NM_005183	human	genbank	54_36p	-1	reviewed	missense	c.942	p.D314E	1	"superfamily_Voltage-gated potassium channels,HMMPfam_Ion_trans"	"superfamily_Voltage-gated potassium channels,HMMPfam_Ion_trans,HMMPfam_Ca_chan_IQ"	-	no_errors	CACNA1F	23	48971731	48971731	p.D314N	c.940G>A	Confirmed
CFP	5199	hgsc.bcm.edu	36	X	47374178	47374178	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-04-1337-01A-01W-0484-10	TCGA-04-1337-11A-01W-0485-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	X	47374178	47374178	C	T	SNP	CFP	NM_002621	human	genbank	54_36p	-1	reviewed	missense	c.10	p.E4K	0	NULL	"superfamily_TSP1,HMMSmart_TSP1,HMMPfam_TSP_1"	-	no_errors	CFP	23	47374180	47374180	p.T3I	c.8C>T	Confirmed
FAM123B	139285	hgsc.bcm.edu	36	X	63329263	63329263	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0889-01A-01W-0419-10	TCGA-13-0889-10A-01W-0419-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	X	63329263	63329263	G	A	SNP	FAM123B	NM_152424	human	genbank	54_36p	-1	validated	missense	c.629	p.S210L	0.11	HMMPfam_WTX	HMMPfam_WTX	-	no_errors	FAM123B	23	63329263	63329263	p.S210*	c.629C>G	Confirmed
ETV3L	440695	hgsc.bcm.edu	36	1	155329520	155329520	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-36-1580-01A-01W-0615-10	TCGA-36-1580-10A-01W-0615-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	1	155329520	155329520	A	G	SNP	ETV3L	NM_001004341	human	genbank	54_36p	-1	provisional	missense	c.631	p.C211R	0.02	NULL	"superfamily_SSF46785,HMMPfam_Ets,HMMSmart_ETS,PatternScan_ETS_DOMAIN_1,PatternScan_ETS_DOMAIN_2"	-	no_errors	ETV3L	1	155329520	155329520	p.C211G	c.631T>G	Confirmed
FAM5C	339479	hgsc.bcm.edu	36	1	188396505	188396505	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-13-0730-01A-01W-0370-10	TCGA-13-0730-10B-01W-0370-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	1	188396505	188396505	A	G	SNP	FAM5C	NM_199051	human	genbank	54_36p	-1	provisional	missense	c.1100	p.L367P	0.97	NULL	"HMMPfam_MACPF,HMMSmart_SM00457"	-	no_errors	FAM5C	1	188396507	188396507	p.F366F	c.1098C>T	Confirmed
FBXO6	26270	hgsc.bcm.edu	36	1	11655959	11655959	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-1408-01A-01W-0490-10	TCGA-13-1408-10A-01W-0491-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	1	11655959	11655959	T	A	SNP	FBXO6	NM_018438	human	genbank	54_36p	1	reviewed	missense	c.548	p.L183H	0.01	"HMMPfam_FBA,superfamily_Galactose-binding domain-like"	"superfamily_F-box domain,HMMPfam_F-box,HMMSmart_SM00256,HMMPfam_FBA,superfamily_Galactose-binding domain-like"	-	no_errors	FBXO6	1	11655960	11655960	p.L183L	c.549C>G	Confirmed
PRKCZ	5590	hgsc.bcm.edu	36	1	2072179	2072179	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-10-0937-01A-02W-0419-10	TCGA-10-0937-11A-01W-0419-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	1	2072179	2072179	C	T	SNP	PRKCZ	NM_002744	human	genbank	54_36p	1	reviewed	missense	c.778	p.R260C	1	"HMMSmart_S_TKc,superfamily_Kinase_like,PatternScan_PROTEIN_KINASE_ATP,HMMPfam_Pkinase"	###############################################################################################################################################################################################################################################################	-	no_errors	PRKCZ	1	2072180	2072180	p.R260H	c.779G>A	Confirmed
TOR1AIP1	26092	hgsc.bcm.edu	36	1	178153307	178153307	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1630-01A-01W-0615-10	TCGA-25-1630-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	1	178153307	178153307	C	A	SNP	TOR1AIP1	NM_015602	human	genbank	54_36p	1	validated	missense	c.1062	p.F354L	0	HMMPfam_LAP1C	HMMPfam_LAP1C	-	no_errors	TOR1AIP1	1	178153307	178153307	p.F354F	c.1062C>T	Confirmed
TRIM58	25893	hgsc.bcm.edu	36	1	246106397	246106397	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-36-1569-01A-01W-0615-10	TCGA-36-1569-10A-01W-0615-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	1	246106397	246106397	A	G	SNP	TRIM58	NM_015431	human	genbank	54_36p	1	validated	missense	c.1444	p.R482G	0.01	NULL	"HMMPfam_zf-B_box,HMMSmart_BBOX,HMMSmart_RING,HMMPfam_SPRY,HMMSmart_PRY,PatternScan_ZF_RING_1,HMMSmart_SPRY,HMMPfam_zf-C3HC4,superfamily_SSF57850"	-	no_errors	TRIM58	1	246106395	246106395	p.V481A	c.1442T>C	Confirmed
BCL11A	53335	hgsc.bcm.edu	36	2	60542989	60542989	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-04-1364-01A-01W-0490-10	TCGA-04-1364-10A-01W-0490-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	2	60542989	60542989	G	A	SNP	BCL11A	NM_022893	human	genbank	54_36p	-1	reviewed	missense	c.562	p.H188Y	1	"superfamily_C2H2 and C2HC zinc fingers,HMMSmart_SM00355,PatternScan_ZINC_FINGER_C2H2_1"	"superfamily_C2H2 and C2HC zinc fingers,HMMSmart_SM00355,PatternScan_ZINC_FINGER_C2H2_1,HMMPfam_zf-C2H2"	-	no_errors	BCL11A	2	60542986	60542986	p.A189T	c.565G>A	Confirmed
RNF25	64320	hgsc.bcm.edu	36	2	219237067	219237067	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-23-1028-01A-01W-0484-10	TCGA-23-1028-10B-01W-0484-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	2	219237067	219237067	T	C	SNP	RNF25	NM_022453	human	genbank	54_36p	-1	reviewed	missense	c.1237	p.R413G	1	NULL	"HMMPfam_RWD,HMMSmart_SM00591,superfamily_UBC-like,superfamily_RING/U-box,HMMSmart_SM00184,HMMPfam_zf-C3HC4"	-	no_errors	RNF25	2	219237065	219237065	p.R413R	c.1239G>A	Confirmed
CELSR3	1951	hgsc.bcm.edu	36	3	48655322	48655322	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-13-0720-01A-01W-0370-10	TCGA-13-0720-10B-01W-0370-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	3	48655322	48655322	C	T	SNP	CELSR3	NM_001407	human	genbank	54_36p	-1	reviewed	splice_site	c.8407-1	e30-1	1	-	-	-	no_errors	CELSR3	3	48655321	48655321	p.G2803R	c.8407G>A	Confirmed
KLF15	28999	hgsc.bcm.edu	36	3	127554211	127554211	+	Missense_Mutation	SNP	G	C	C	novel	Unknown	TCGA-13-0717-01A-01W-0370-10	TCGA-13-0717-10B-01W-0370-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	3	127554211	127554211	G	C	SNP	KLF15	NM_014079	human	genbank	54_36p	-1	validated	missense	c.245	p.S82C	1	NULL	"superfamily_SSF57667,HMMPfam_zf-C2H2,HMMSmart_ZnF_C2H2,PatternScan_ZINC_FINGER_C2H2_1"	-	no_errors	KLF15	3	127554212	127554212	p.S82T	c.244T>A	Confirmed
PBRM1	55193	hgsc.bcm.edu	36	3	52660820	52660820	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-09-1661-01B-01W-0615-10	TCGA-09-1661-10A-01W-0616-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	3	52660820	52660820	T	C	SNP	PBRM1	NM_018165	human	genbank	54_36p	-1	validated	missense	c.692	p.K231R	1	"superfamily_Bromodomain,HMMSmart_BROMO,HMMPfam_Bromodomain,PatternScan_BROMODOMAIN_1"	"superfamily_Bromodomain,HMMSmart_BROMO,HMMPfam_Bromodomain,PatternScan_BROMODOMAIN_1,HMMPfam_BAH,HMMSmart_BAH,superfamily_HMG-box,HMMSmart_HMG,HMMPfam_HMG_box"	-	no_errors	PBRM1				p.T232P	c.694A>C	Confirmed
RTP1	132112	hgsc.bcm.edu	36	3	188400128	188400128	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-24-1548-01A-01W-0615-10	TCGA-24-1548-10A-01W-0615-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	3	188400128	188400128	T	C	SNP	RTP1	NM_153708	human	genbank	54_36p	1	validated	missense	c.368	p.V123A	1	NULL	NULL	-	no_errors	RTP1	3	188400130	188400130	p.R124S	c.370C>A	Confirmed
SETD2	29072	hgsc.bcm.edu	36	3	47137595	47137595	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-36-1569-01A-01W-0615-10	TCGA-36-1569-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	3	47137595	47137595	C	G	SNP	SETD2	NM_014159	human	genbank	54_36p	-1	reviewed	missense	c.2026	p.D676H	0.65	NULL	"superfamily_Ferritin/RR_like,superfamily_SSF82199,HMMSmart_AWS,HMMPfam_SET,HMMSmart_SET,HMMSmart_PostSET,superfamily_WW_Rsp5_WWP,HMMSmart_WW,HMMPfam_WW,PatternScan_WW_DOMAIN_1,HMMPfam_SRI_2"	-	no_errors	SETD2	3	47137593	47137593	p.D676D	c.2028C>T	Confirmed
FBXW7	55294	hgsc.bcm.edu	36	4	153468834	153468834	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-04-1337-01A-01W-0484-10	TCGA-04-1337-11A-01W-0485-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	4	153468834	153468834	C	T	SNP	FBXW7	NM_033632	human	genbank	54_36p	-1	reviewed	missense	c.1394	p.R465H	1	"superfamily_WD40 repeat-like,HMMSmart_SM00320,HMMPfam_WD40"	"superfamily_WD40 repeat-like,superfamily_F-box domain,HMMPfam_F-box,HMMSmart_SM00256,HMMSmart_SM00320,HMMPfam_WD40,PatternScan_WD_REPEATS_1"	-	no_errors	FBXW7	4	153468834	153468834	p.R465H	c.1394G>A	Previously Observed
ARHGEF38	54848	hgsc.bcm.edu	36	4	106729858	106729858	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-1408-01A-01W-0490-10	TCGA-13-1408-10A-01W-0491-10	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	4	106729858	106729858	G	C	SNP	FLJ20184	NM_017700	human	genbank	54_36p	1	predicted	missense	c.201	p.K67N	1	NULL	"HMMPfam_RhoGEF,superfamily_DH-domain,PatternScan_DH_1"	-	no_errors	FLJ20184	4	106729858	106729858	p.K67N	c.201G>C	Confirmed
KIT	3815	hgsc.bcm.edu	36	4	55288401	55288401	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1625-01A-01W-0615-10	TCGA-25-1625-10A-01W-0615-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	4	55288401	55288401	C	A	SNP	KIT	NM_000222	human	genbank	54_36p	1	reviewed	nonsense	c.1710	p.Y570*	1	NULL	"HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc,PatternScan_RECEPTOR_TYR_KIN_III,HMMSmart_IGc2,HMMSmart_IG,PatternScan_PROTEIN_KINASE_TYR,superfamily_Kinase_like,HMMPfam_ig,PatternScan_PROTEIN_KINASE_ATP,superfamily_SSF48726"	-	no_errors	KIT	4	55288397	55288397	p.V569A	c.1706T>C	Confirmed
APC	324	hgsc.bcm.edu	36	5	112201745	112201745	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-0793-01A-01W-0370-10	TCGA-13-0793-10A-01W-0370-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	5	112201745	112201745	T	C	SNP	APC	NM_000038	human	genbank	54_36p	1	reviewed	missense	c.2555	p.L852S	0.98	NULL	"HMMPfam_Arm,HMMSmart_SM00185,HMMPfam_APC_crr,HMMPfam_SAMP,HMMPfam_EB1_binding,HMMPfam_APC_basic,HMMPfam_APC_15aa,superfamily_ARM repeat"	-	no_errors	APC	5	112201745	112201745	p.L852*	c.2555T>A	Confirmed
APC	324	hgsc.bcm.edu	36	5	112203047	112203047	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-04-1338-01A-01W-0484-10	TCGA-04-1338-11A-01W-0485-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	5	112203047	112203047	A	G	SNP	APC	NM_000038	human	genbank	54_36p	1	reviewed	missense	c.3857	p.E1286G	1	NULL	"HMMPfam_Arm,HMMSmart_SM00185,HMMPfam_APC_crr,HMMPfam_SAMP,HMMPfam_EB1_binding,HMMPfam_APC_basic,HMMPfam_APC_15aa,superfamily_ARM repeat"	-	no_errors	APC	5	112203047	112203047	p.I1287fs*1	c.3857delA	Confirmed
KDM3B	51780	hgsc.bcm.edu	36	5	137736317	137736317	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-09-1665-01B-01W-0615-10	TCGA-09-1665-11B-01W-0616-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	5	137736317	137736317	A	G	SNP	JMJD1B	NM_016604	human	genbank	54_36p	1	validated	missense	c.248	p.H83R	1	NULL	"superfamily_Clavaminate synthase-like,HMMSmart_SM00558,HMMPfam_JmjC"	-	no_errors	JMJD1B	5	137736316	137736316	p.H83Y	c.247C>T	Confirmed
MAPK9	5601	hgsc.bcm.edu	36	5	179624429	179624429	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-0714-01A-01W-0370-10	TCGA-13-0714-10B-01W-0370-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	5	179624429	179624429	T	C	SNP	MAPK9	NM_002752	human	genbank	54_36p	-1	reviewed	missense	c.269	p.N90S	1	"superfamily_Protein kinase-like (PK-like),HMMSmart_SM00219,HMMSmart_SM00220,HMMPfam_Pkinase,PatternScan_MAPK"	"superfamily_Protein kinase-like (PK-like),HMMSmart_SM00219,HMMSmart_SM00220,HMMPfam_Pkinase,PatternScan_MAPK,PatternScan_PROTEIN_KINASE_ST"	-	no_errors	MAPK9	5	179624427	179624427	p.V91M	c.271G>A	Confirmed
NIPBL	25836	hgsc.bcm.edu	36	5	37011811	37011811	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-13-0730-01A-01W-0370-10	TCGA-13-0730-10B-01W-0370-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	5	37011811	37011811	A	G	SNP	NIPBL	NM_133433	human	genbank	54_36p	1	reviewed	missense	c.1045	p.S349G	1	superfamily_ARM repeat	superfamily_ARM repeat	-	no_errors	NIPBL	5	37011811	37011811	p.S349C	c.1045A>T	Confirmed
NIPBL	25836	hgsc.bcm.edu	36	5	37055186	37055186	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-25-1626-01A-01W-0615-10	TCGA-25-1626-10A-01W-0615-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	5	37055186	37055186	A	G	SNP	NIPBL	NM_133433	human	genbank	54_36p	1	reviewed	missense	c.4937	p.D1646G	1	superfamily_ARM repeat	superfamily_ARM repeat	-	no_errors	NIPBL	5	37055188	37055188	p.E1647K	c.4939G>A	Confirmed
NR2F1	7025	hgsc.bcm.edu	36	5	92946865	92946865	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-1614-01A-01W-0552-10	TCGA-24-1614-10A-01W-0552-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	5	92946865	92946865	A	G	SNP	NR2F1	NM_005654	human	genbank	54_36p	1	provisional	missense	c.380	p.N127S	1	"HMMSmart_ZnF_C4,HMMPfam_zf-C4,superfamily_SSF57716"	"HMMSmart_ZnF_C4,HMMPfam_zf-C4,superfamily_SSF57716,PatternScan_NUCLEAR_REC_DBD_1,superfamily_Str_ncl_receptor,HMMPfam_zf-C4_C,HMMSmart_HOLI,HMMPfam_Hormone_recep"	-	no_errors	NR2F1	5	92946863	92946863	p.R126R	c.378G>A	Confirmed
UGT3A2	167127	hgsc.bcm.edu	36	5	36071585	36071585	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-36-1580-01A-01W-0615-10	TCGA-36-1580-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	5	36071585	36071585	C	T	SNP	UGT3A2	NM_174914	human	genbank	54_36p	-1	provisional	missense	c.1544	p.R515H	0.18	HMMPfam_UDPGT	"superfamily_SSF53756,HMMPfam_UDPGT,PatternScan_UDPGT"	-	no_errors	UGT3A2	5	36071585	36071585	p.R515H	c.1544G>A	Confirmed
TNFAIP3	7128	hgsc.bcm.edu	36	6	138237686	138237686	+	Missense_Mutation	SNP	T	T	G	novel	Unknown	TCGA-09-1661-01B-01W-0615-10	TCGA-09-1661-10A-01W-0616-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	6	138237686	138237686	T	G	SNP	TNFAIP3	NM_006290	human	genbank	54_36p	1	reviewed	missense	c.307	p.C103G	1	HMMPfam_OTU	"HMMPfam_zf-A20,HMMSmart_ZnF_A20,HMMPfam_OTU"	-	no_errors	TNFAIP3	6	138237684	138237684	p.N102S	c.305A>G	Unknown
TTK	7272	hgsc.bcm.edu	36	6	80808616	80808616	+	Frame_Shift_Del	DEL	A	A	-	novel	Unknown	TCGA-25-1317-01A-01W-0490-10	TCGA-25-1317-10A-01W-0490-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	6	80808616	80808616	A	-	DEL	TTK	NM_003318	human	genbank	54_36p	1	provisional	frame_shift_del	c.2552	p.R854fs	0.08	NULL	"HMMSmart_S_TKc,PatternScan_PROTEIN_KINASE_ST,superfamily_Kinase_like,PatternScan_PROTEIN_KINASE_ATP,HMMPfam_Pkinase"	"(deletion:cds_exon[80808555,80808638])"	no_errors	TTK	6	80808616	80808616	p.R838fs*4	c.2512delA	Confirmed
EGFR	1956	hgsc.bcm.edu	36	7	55209171	55209171	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-0900-01B-01W-0490-10	TCGA-13-0900-10A-01W-0490-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	7	55209171	55209171	G	C	SNP	EGFR	NM_005228	human	genbank	54_36p	1	reviewed	missense	c.2125	p.E709Q	1	superfamily_Protein kinase-like (PK-like)	###############################################################################################################################################################################################################################################################	-	no_errors	EGFR	7	55209171	55209171	p.E709K	c.2125G>A	Previously Observed
EGFR	1956	hgsc.bcm.edu	36	7	55216511	55216511	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-13-0919-01A-01W-0419-10	TCGA-13-0919-10A-01W-0419-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	7	55216511	55216511	C	G	SNP	EGFR	NM_005228	human	genbank	54_36p	1	reviewed	missense	c.2315	p.P772R	1	"HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like)"	###############################################################################################################################################################################################################################################################	-	no_errors	EGFR	7	55216511	55216512	p.P772_H773insTHP	c.2315_2316insGACACACCC	Confirmed
EGFR	1956	hgsc.bcm.edu	36	7	55226952	55226952	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0717-01A-01W-0370-10	TCGA-13-0717-10B-01W-0370-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	7	55226952	55226952	C	T	SNP	EGFR	NM_005228	human	genbank	54_36p	1	reviewed	missense	c.2516	p.A839V	1	"HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,PatternScan_PROTEIN_KINASE_TYR,superfamily_Protein kinase-like (PK-like)"	###############################################################################################################################################################################################################################################################	-	no_errors	EGFR	7	55226948	55226948	p.L838V	c.2512C>G	Confirmed
EPHB4	2050	hgsc.bcm.edu	36	7	100248358	100248358	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-23-1023-01A-03W-0484-10	TCGA-23-1023-10A-01W-0484-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	7	100248358	100248358	C	T	SNP	EPHB4	NM_004444	human	genbank	54_36p	-1	reviewed	missense	c.2065	p.V689I	0.98	"superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220"	###############################################################################################################################################################################################################################################################	-	no_errors	EPHB4	7	100248359	100248359	p.P688P	c.2064C>A	Confirmed
PIK3CG	5294	hgsc.bcm.edu	36	7	106296575	106296575	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-13-0792-01A-01W-0370-10	TCGA-13-0792-10A-01W-0370-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	7	106296575	106296575	G	T	SNP	PIK3CG	NM_002649	human	genbank	54_36p	1	reviewed	missense	c.1333	p.A445S	0.19	"HMMSmart_SM00142,superfamily_C2 domain (Calcium/lipid-binding domain CaLB),HMMPfam_PI3K_C2"	###############################################################################################################################################################################################################################################################	-	no_errors	PIK3CG	7	106296576	106296576	p.A445V	c.1334C>T	Confirmed
SNX8	29886	hgsc.bcm.edu	36	7	2278112	2278112	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-36-1568-01A-01W-0615-10	TCGA-36-1568-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	7	2278112	2278112	C	A	SNP	SNX8	NM_013321	human	genbank	54_36p	-1	provisional	missense	c.439	p.A147S	1	"HMMPfam_PX,HMMSmart_SM00312,superfamily_PX domain"	"HMMPfam_PX,HMMSmart_SM00312,superfamily_PX domain"	-	no_errors	SNX8	7	2278111	2278111	p.A147G	c.440C>G	Confirmed
MTDH	92140	hgsc.bcm.edu	36	8	98800510	98800510	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-09-1662-01A-01W-0615-10	TCGA-09-1662-10A-01W-0616-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	8	98800510	98800510	A	G	SNP	MTDH	NM_178812	human	genbank	54_36p	1	validated	missense	c.1438	p.T480A	1	NULL	NULL	-	no_errors	MTDH	8	98800512	98800512	p.T480T	c.1440C>T	Confirmed
CD274	29126	hgsc.bcm.edu	36	9	5452907	5452907	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-25-1627-01A-01W-0615-10	TCGA-25-1627-10A-01W-0615-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	9	5452907	5452907	G	T	SNP	CD274	NM_014143	human	genbank	54_36p	1	provisional	missense	c.468	p.Q156H	1	"superfamily_Immunoglobulin,HMMPfam_C2-set_2,HMMSmart_SM00409"	"superfamily_Immunoglobulin,HMMSmart_SM00409,HMMPfam_ig,HMMPfam_C2-set_2"	-	no_errors	CD274	9	5452908	5452908	p.A157T	c.469G>A	Confirmed
JAK2	3717	hgsc.bcm.edu	36	9	5062586	5062586	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-36-1568-01A-01W-0615-10	TCGA-36-1568-10A-01W-0615-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	9	5062586	5062586	T	C	SNP	JAK2	NM_004972	human	genbank	54_36p	1	reviewed	missense	c.1736	p.L579P	1	"superfamily_Kinase_like,HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc"	"PatternScan_FERM_1,PatternScan_FERM_2,HMMSmart_B41,superfamily_SSF55550,HMMSmart_SH2,HMMPfam_SH2,superfamily_Kinase_like,HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc,PatternScan_PROTEIN_KINASE_ATP,PatternScan_PROTEIN_KINASE_TYR"	-	no_errors	JAK2	9	5062585	5062585	p.L579F	c.1735C>T	Unknown
NOTCH1	4851	hgsc.bcm.edu	36	9	138510763	138510763	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-0761-01A-01W-0370-10	TCGA-13-0761-10A-01W-0370-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	9	138510763	138510763	G	C	SNP	NOTCH1	NM_017617	human	genbank	54_36p	-1	reviewed	missense	c.7249	p.P2417A	0.61	NULL	###############################################################################################################################################################################################################################################################	-	no_errors	NOTCH1				p.P2416del	c.?	Unknown
PTCH1	5727	hgsc.bcm.edu	36	9	97279757	97279757	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-0717-01A-01W-0370-10	TCGA-13-0717-10B-01W-0370-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	9	97279757	97279757	G	C	SNP	PTCH1	NM_000264	human	genbank	54_36p	-1	reviewed	missense	c.1396	p.Q466E	1	"HMMPfam_Patched,superfamily_SSF82866"	"HMMPfam_Patched,superfamily_SSF82866"	-	no_errors	PTCH1	9	97279757	97279757	p.Q466*	c.1396C>T	Confirmed
MYO3A	53904	hgsc.bcm.edu	36	10	26425326	26425326	+	Missense_Mutation	SNP	A	C	C	novel	Unknown	TCGA-13-0730-01A-01W-0370-10	TCGA-13-0730-10B-01W-0370-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	10	26425326	26425326	A	C	SNP	MYO3A	NM_017433	human	genbank	54_36p	1	reviewed	missense	c.1573	p.N525H	1	"superfamily_SSF52540,HMMSmart_MYSc,HMMPfam_Myosin_head"	"PatternScan_PROTEIN_KINASE_ST,superfamily_Kinase_like,HMMSmart_S_TKc,HMMPfam_Pkinase,PatternScan_PROTEIN_KINASE_ATP,superfamily_SSF52540,HMMSmart_MYSc,HMMPfam_Myosin_head,HMMSmart_IQ,HMMPfam_IQ"	-	no_errors	MYO3A	10	26425328	26425328	p.N525K	c.1575T>A	Confirmed
MYO3A	53904	hgsc.bcm.edu	36	10	26425327	26425327	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-1105-01A-01W-0484-10	TCGA-24-1105-10A-01W-0484-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	10	26425327	26425327	A	G	SNP	MYO3A	NM_017433	human	genbank	54_36p	1	reviewed	missense	c.1574	p.N525S	1	"HMMPfam_Myosin_head,HMMSmart_MYSc,superfamily_SSF52540"	"HMMPfam_IQ,HMMSmart_IQ,HMMPfam_Myosin_head,HMMSmart_MYSc,HMMSmart_S_TKc,PatternScan_PROTEIN_KINASE_ST,superfamily_Kinase_like,PatternScan_PROTEIN_KINASE_ATP,HMMPfam_Pkinase,superfamily_SSF52540"	-	no_errors	MYO3A	10	26425328	26425328	p.N525K	c.1575T>A	Confirmed
MYO3A	53904	hgsc.bcm.edu	36	10	26425327	26425327	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-1553-01A-01W-0552-10	TCGA-24-1553-10A-01W-0552-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	10	26425327	26425327	A	G	SNP	MYO3A	NM_017433	human	genbank	54_36p	1	reviewed	missense	c.1574	p.N525S	1	"HMMPfam_Myosin_head,HMMSmart_MYSc,superfamily_SSF52540"	"HMMPfam_IQ,HMMSmart_IQ,HMMPfam_Myosin_head,HMMSmart_MYSc,HMMSmart_S_TKc,PatternScan_PROTEIN_KINASE_ST,superfamily_Kinase_like,PatternScan_PROTEIN_KINASE_ATP,HMMPfam_Pkinase,superfamily_SSF52540"	-	no_errors	MYO3A	10	26425328	26425328	p.N525K	c.1575T>A	Confirmed
MYST4	23522	hgsc.bcm.edu	36	10	76451912	76451914	+	In_Frame_Del	DEL	GAA	GAA	-	rs3217598	Unknown	TCGA-23-1028-01A-01W-0484-10	TCGA-23-1028-10B-01W-0484-10	GAA	GAA	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	10	76451912	76451914	GAA	-	DEL	MYST4	NM_012330	human	genbank	54_36p	1	validated	in_frame_del	c.3289_3291	p.E1100in_frame_del	0.145:0.135:0.125	NULL	"HMMSmart_SM00249,HMMPfam_MOZ_SAS,HMMSmart_SM00526,superfamily_FYVE/PHD zinc finger,superfamily_Acyl-CoA N-acyltransferases (Nat),PatternScan_ZF_PHD_1,HMMPfam_PHD,superfamily_Winged helix DNA-binding domain"	"(deletion:cds_exon[76451645,76451995])"	no_errors	MYST4	10	76451914	76451914	p.E1097E	c.3291A>G	Confirmed
MYST4	23522	hgsc.bcm.edu	36	10	76451914	76451914	+	Silent	SNP	A	A	G	novel	Unknown	TCGA-09-1661-01B-01W-0615-10	TCGA-09-1661-10A-01W-0616-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	10	76451914	76451914	A	G	SNP	MYST4	NM_012330	human	genbank	54_36p	1	validated	silent	c.3291	p.E1097	0.13	NULL	"HMMSmart_SM00249,HMMPfam_MOZ_SAS,HMMSmart_SM00526,superfamily_FYVE/PHD zinc finger,superfamily_Acyl-CoA N-acyltransferases (Nat),PatternScan_ZF_PHD_1,HMMPfam_PHD,superfamily_Winged helix DNA-binding domain"	-	no_errors	MYST4	10	76451914	76451914	p.E1097E	c.3291A>G	Confirmed
MYST4	23522	hgsc.bcm.edu	36	10	76451914	76451914	+	Silent	SNP	A	A	G	novel	Unknown	TCGA-24-1545-01A-01W-0615-10	TCGA-24-1545-10A-01W-0615-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	10	76451914	76451914	A	G	SNP	MYST4	NM_012330	human	genbank	54_36p	1	validated	silent	c.3291	p.E1097	0.13	NULL	"HMMSmart_SM00249,HMMPfam_MOZ_SAS,HMMSmart_SM00526,superfamily_FYVE/PHD zinc finger,superfamily_Acyl-CoA N-acyltransferases (Nat),PatternScan_ZF_PHD_1,HMMPfam_PHD,superfamily_Winged helix DNA-binding domain"	-	no_errors	MYST4	10	76451914	76451914	p.E1097E	c.3291A>G	Confirmed
PI4K2A	55361	hgsc.bcm.edu	36	10	99406689	99406689	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-0717-01A-01W-0370-10	TCGA-13-0717-10B-01W-0370-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	10	99406689	99406689	T	C	SNP	PI4K2A	NM_018425	human	genbank	54_36p	1	provisional	missense	c.890	p.L297S	1	HMMPfam_PI3_PI4_kinase	"PatternScan_PI3_4_KINASE_1,PatternScan_PI3_4_KINASE_2,superfamily_SSF56399,HMMPfam_PI3_PI4_kinase"	-	no_errors	PI4K2A	10	99406691	99406691	p.V298M	c.892G>A	Confirmed
KRTAP5-5	439915	hgsc.bcm.edu	36	11	1607696	1607696	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-10-0938-01A-02W-0419-10	TCGA-10-0938-11A-01W-0419-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	11	1607696	1607696	G	T	SNP	KRTAP5-5	NM_001001480	human	genbank	54_36p	1	validated	missense	c.50	p.R17L	0.99	NULL	"PatternScan_MOLYBDOPTERIN_PROK_1,PatternScan_2FE2S_FER_1"	-	no_errors	KRTAP5-5	11	1607695	1607695	p.R17C	c.49C>T	Confirmed
MMP3	4314	hgsc.bcm.edu	36	11	102215174	102215174	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-10-0937-01A-02W-0419-10	TCGA-10-0937-11A-01W-0419-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	11	102215174	102215174	G	A	SNP	MMP3	NM_002422	human	genbank	54_36p	-1	reviewed	missense	c.946	p.R316C	1	"superfamily_Hemopexin-like domain,HMMPfam_Hemopexin,HMMSmart_SM00120"	###############################################################################################################################################################################################################################################################	-	no_errors	MMP3	11	102215174	102215174	p.R316C	c.946C>T	Confirmed
MUC15	143662	hgsc.bcm.edu	36	11	26541255	26541255	+	Silent	SNP	G	G	A	novel	Unknown	TCGA-24-1558-01A-01W-0615-10	TCGA-24-1558-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	11	26541255	26541255	G	A	SNP	MUC15	NM_145650	human	genbank	54_36p	-1	validated	silent	c.828	p.D276	0.99	NULL	NULL	-	no_errors	MUC15	11	26541255	26541255	p.D276D	c.828C>T	Confirmed
SCYL1	57410	hgsc.bcm.edu	36	11	65060098	65060098	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-04-1530-01A-02W-0552-10	TCGA-04-1530-10A-01W-0552-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	11	65060098	65060098	C	G	SNP	SCYL1	NM_020680	human	genbank	54_36p	1	reviewed	missense	c.1485	p.H495Q	1	superfamily_ARM repeat	"superfamily_Protein kinase-like (PK-like),superfamily_ARM repeat,HMMPfam_HEAT"	-	no_errors	SCYL1	11	65060096	65060096	p.H495Y	c.1483C>T	Confirmed
WNT11	7481	hgsc.bcm.edu	36	11	75575791	75575791	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-36-1575-01A-01W-0615-10	TCGA-36-1575-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	11	75575791	75575791	C	T	SNP	WNT11	NM_004626	human	genbank	54_36p	-1	reviewed	missense	c.1031	p.C344Y	0.99	"HMMPfam_wnt,HMMSmart_WNT1"	"HMMPfam_wnt,HMMSmart_WNT1,PatternScan_WNT1"	-	no_errors	WNT11	11	75575793	75575793	p.R343R	c.1029G>A	Confirmed
WNT11	7481	hgsc.bcm.edu	36	11	75575791	75575791	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-57-1583-01A-01W-0615-10	TCGA-57-1583-11A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	11	75575791	75575791	C	T	SNP	WNT11	NM_004626	human	genbank	54_36p	-1	reviewed	missense	c.1031	p.C344Y	0.99	"HMMPfam_wnt,HMMSmart_WNT1"	"HMMPfam_wnt,HMMSmart_WNT1,PatternScan_WNT1"	-	no_errors	WNT11	11	75575793	75575793	p.R343R	c.1029G>A	Confirmed
CHD4	1108	hgsc.bcm.edu	36	12	6575524	6575524	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-0906-01A-01W-0419-10	TCGA-13-0906-10A-01W-0419-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	12	6575524	6575524	G	C	SNP	CHD4	NM_001273	human	genbank	54_36p	-1	reviewed	missense	c.1933	p.R645G	1	"HMMPfam_Chromo,HMMSmart_SM00298,PatternScan_CHROMO_1,superfamily_P-loop containing nucleoside triphosphate hydrolases"	###############################################################################################################################################################################################################################################################	-	no_errors	CHD4	12	6575522	6575522	p.R645R	c.1935G>A	Confirmed
DDIT3	1649	hgsc.bcm.edu	36	12	56197026	56197026	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-09-1661-01B-01W-0615-10	TCGA-09-1661-10A-01W-0616-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	12	56197026	56197026	C	T	SNP	DDIT3	NM_004083	human	genbank	54_36p	-1	validated	missense	c.343	p.A115T	1	"HMMSmart_SM00338,HMMPfam_bZIP_2"	"HMMSmart_SM00338,HMMPfam_bZIP_2"	-	no_errors	DDIT3	12	56197025	56197025	p.A115V	c.344C>T	Confirmed
GLI1	2735	hgsc.bcm.edu	36	12	56152069	56152069	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-23-1120-01A-02W-0484-10	TCGA-23-1120-10A-01W-0484-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	12	56152069	56152069	A	T	SNP	GLI1	NM_005269	human	genbank	54_36p	1	reviewed	missense	c.3279	p.R1093S	1	NULL	"HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667"	-	no_errors	GLI1	12	56152071	56152071	p.S1094F	c.3281C>T	Confirmed
HNF1A	6927	hgsc.bcm.edu	36	12	119921766	119921766	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-36-1569-01A-01W-0615-10	TCGA-36-1569-10A-01W-0615-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	12	119921766	119921766	G	A	SNP	HNF1A	NM_000545	human	genbank	54_36p	1	reviewed	missense	c.1721	p.S574N	0.09	HMMPfam_HNF-1A_C	"superfamily_Dimerization cofactor of HNF-1 alpha,HMMPfam_HNF-1_N,superfamily_lambda repressor-like DNA-binding domains,superfamily_Homeodomain-like,HMMSmart_SM00389,HMMPfam_Homeobox,PatternScan_HOMEOBOX_1,HMMPfam_HNF-1B_C,HMMPfam_HNF-1A_C"	-	no_errors	HNF1A	12	119921766	119921766	p.G574D	c.1721G>A	Confirmed
MLL2	8085	hgsc.bcm.edu	36	12	47711527	47711527	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-23-1023-01A-03W-0484-10	TCGA-23-1023-10A-01W-0484-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	12	47711527	47711527	C	A	SNP	MLL2	NM_003482	human	genbank	54_36p	-1	validated	missense	c.13228	p.A4410S	0.11	NULL	###############################################################################################################################################################################################################################################################	-	no_errors	MLL2	12	47709489	47709489	p.A4409A	c.13227C>T	Confirmed
UNG	7374	hgsc.bcm.edu	36	12	108020600	108020600	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-36-1568-01A-01W-0615-10	TCGA-36-1568-10A-01W-0615-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	12	108020600	108020600	T	C	SNP	UNG	NM_003362	human	genbank	54_36p	1	reviewed	missense	c.86	p.L29P	0	NULL	"superfamily_DNA glycosylase,HMMPfam_UDG,PatternScan_U_DNA_GLYCOSYLASE"	-	no_errors	UNG	12	108020601	108020601	p.L29L	c.87C>T	Confirmed
PCDH20	64881	hgsc.bcm.edu	36	13	60884665	60884665	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-36-1577-01A-01W-0615-10	TCGA-36-1577-10A-01W-0615-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	13	60884665	60884665	A	C	SNP	PCDH20	NM_022843	human	genbank	54_36p	-1	validated	missense	c.1487	p.V496G	1	"superfamily_Cadherin,HMMSmart_CA,PatternScan_CADHERIN_1"	"HMMPfam_Cadherin_2,PatternScan_CADHERIN_1,superfamily_Cadherin,HMMPfam_Cadherin,HMMSmart_CA"	-	no_errors	PCDH20	13	60884666	60884666	p.V496M	c.1486G>A	Confirmed
BRF1	2972	hgsc.bcm.edu	36	14	104755073	104755073	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-10-0937-01A-02W-0419-10	TCGA-10-0937-11A-01W-0419-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	14	104755073	104755073	A	G	SNP	BRF1	NM_001519	human	genbank	54_36p	-1	reviewed	missense	c.1625	p.V542A	1	HMMPfam_BRF1	"HMMPfam_TFIIB_Zn_Ribbon,superfamily_Zinc beta-ribbon,superfamily_Cyclin-like,HMMSmart_SM00385,HMMPfam_TFIIB,HMMPfam_BRF1"	-	no_errors	BRF1	14	104755074	104755074	p.V542M	c.1624G>A	Confirmed
FOXG1	2290	hgsc.bcm.edu	36	14	28307616	28307616	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-09-1665-01B-01W-0615-10	TCGA-09-1665-11B-01W-0616-10	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	14	28307616	28307616	G	C	SNP	FOXG1	NM_005249	human	genbank	54_36p	1	reviewed	missense	c.1380	p.L460F	1	NULL	"HMMSmart_FH,superfamily_SSF46785,PatternScan_FORK_HEAD_1,HMMPfam_Fork_head,PatternScan_FORK_HEAD_2"	-	no_errors	FOXG1	14	28307616	28307616	p.L460F	c.1380G>C	Confirmed
RBM25	58517	hgsc.bcm.edu	36	14	72645841	72645841	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-25-1634-01A-01W-0615-10	TCGA-25-1634-10A-01W-0616-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	14	72645841	72645841	A	G	SNP	RBM25	NM_021239	human	genbank	54_36p	1	validated	missense	c.1580	p.K527R	1	NULL	"superfamily_RNA-binding domain RBD,HMMSmart_SM00360,HMMPfam_RRM_1,superfamily_PWI domain,HMMSmart_SM00311,HMMPfam_PWI"	-	no_errors	RBM25	14	72645842	72645842	p.K527K	c.1581G>A	Confirmed
SLC24A4	123041	hgsc.bcm.edu	36	14	92018837	92018837	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-0900-01B-01W-0490-10	TCGA-13-0900-10A-01W-0490-10	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	14	92018837	92018837	T	A	SNP	SLC24A4	NM_153646	human	genbank	54_36p	1	validated	missense	c.1265	p.V422D	0.97	NULL	HMMPfam_Na_Ca_ex	-	no_errors	SLC24A4	14	92018836	92018836	p.V422I	c.1264G>A	Confirmed
FURIN	5045	hgsc.bcm.edu	36	15	89225685	89225685	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-36-1577-01A-01W-0615-10	TCGA-36-1577-10A-01W-0615-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	15	89225685	89225685	G	A	SNP	FURIN	NM_002569	human	genbank	54_36p	1	reviewed	missense	c.1958	p.G653E	1	"superfamily_Grow_fac_recept,HMMSmart_FU"	"superfamily_Prot_inh_propept,superfamily_Pept_S8_S53,HMMPfam_Peptidase_S8,PatternScan_SUBTILASE_ASP,PatternScan_SUBTILASE_HIS,PatternScan_SUBTILASE_SER,superfamily_Gal_bind_like,HMMPfam_P_proprotein,HMMSmart_FU,superfamily_Grow_fac_recept"	-	no_errors	FURIN	15	89225687	89225687	p.P654S	c.1960C>T	Confirmed
ABCA3	21	hgsc.bcm.edu	36	16	2276769	2276769	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-04-1337-01A-01W-0484-10	TCGA-04-1337-11A-01W-0485-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	16	2276769	2276769	G	A	SNP	ABCA3	NM_001089	human	genbank	54_36p	-1	reviewed	missense	c.3205	p.H1069Y	0.04	NULL	"superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00382,HMMPfam_ABC_tran,PatternScan_ABC_TRANSPORTER_1"	-	no_errors	ABCA3	16	2276767	2276767	p.H1069Q	c.3207C>G	Confirmed
ATP2A1	487	hgsc.bcm.edu	36	16	28820694	28820694	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-04-1525-01A-01W-0615-10	TCGA-04-1525-10A-01W-0615-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	16	28820694	28820694	G	T	SNP	ATP2A1	NM_173201	human	genbank	54_36p	1	reviewed	missense	c.2110	p.G704C	1	"superfamily_Calcium ATPase transmembrane domain M,HMMPfam_Hydrolase,superfamily_HAD-like"	###############################################################################################################################################################################################################################################################	-	no_errors	ATP2A1	16	28820696	28820696	p.G704G	c.2112C>T	Confirmed
C16orf79	283870	hgsc.bcm.edu	36	16	2199694	2199694	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-36-1576-01A-01W-0615-10	TCGA-36-1576-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	16	2199694	2199694	C	A	SNP	C16orf79	NM_182563	human	genbank	54_36p	-1	predicted	missense	c.453	p.W151C	0	NULL	NULL	-	no_errors	C16orf79	16	2199693	2199693	p.V152I	c.454G>A	Confirmed
CDH1	999	hgsc.bcm.edu	36	16	67403201	67403201	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-04-1337-01A-01W-0484-10	TCGA-04-1337-11A-01W-0485-10	A	A	G	A	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	16	67403201	67403201	A	G	SNP	CDH1	NM_004360	human	genbank	54_36p	1	reviewed	missense	c.946	p.M316V	0.91	"superfamily_Cadherin-like,HMMPfam_Cadherin,HMMSmart_SM00112"	"superfamily_Cadherin-like,HMMPfam_Cadherin_pro,HMMPfam_Cadherin,HMMSmart_SM00112,PatternScan_CADHERIN_1,HMMPfam_Cadherin_C"	-	no_errors	CDH1	16	67403199	67403199	p.N315S	c.944A>G	Confirmed
CDC27	996	hgsc.bcm.edu	36	17	42571159	42571159	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-04-1337-01A-01W-0484-10	TCGA-04-1337-11A-01W-0485-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	17	42571159	42571159	A	C	SNP	CDC27	NM_001256	human	genbank	54_36p	-1	reviewed	missense	c.1649	p.V550G	1	superfamily_SSF48452	"superfamily_SSF48452,HMMPfam_TPR_1,HMMSmart_TPR"	-	no_errors	CDC27	17	42571161	42571161	p.D549E	c.1647T>G	Confirmed
CDC27	996	hgsc.bcm.edu	36	17	42571161	42571161	+	Missense_Mutation	SNP	A	C	C	novel	Unknown	TCGA-13-0919-01A-01W-0419-10	TCGA-13-0919-10A-01W-0419-10	A	A	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	17	42571161	42571161	A	C	SNP	CDC27	NM_001256	human	genbank	54_36p	-1	reviewed	missense	c.1647	p.D549E	1	superfamily_SSF48452	"HMMPfam_TPR_1,HMMSmart_TPR,superfamily_SSF48452"	-	no_errors	CDC27	17	42571161	42571161	p.D549E	c.1647T>G	Confirmed
ERBB2	2064	hgsc.bcm.edu	36	17	35121734	35121734	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0889-01A-01W-0419-10	TCGA-13-0889-10A-01W-0419-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	35121734	35121734	C	T	SNP	ERBB2	NM_004448	human	genbank	54_36p	1	reviewed	missense	c.929	p.S310F	1	"superfamily_Growth factor receptor domain,HMMPfam_Furin-like"	###############################################################################################################################################################################################################################################################	-	no_errors	ERBB2	17	35121734	35121734	p.S310F	c.929C>T	Confirmed
ERBB2	2064	hgsc.bcm.edu	36	17	35135143	35135143	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-09-1665-01B-01W-0615-10	TCGA-09-1665-11B-01W-0616-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	17	35135143	35135143	G	A	SNP	ERBB2	NM_004448	human	genbank	54_36p	1	reviewed	missense	c.2687	p.R896H	1	"HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like)"	###############################################################################################################################################################################################################################################################	-	no_errors	ERBB2	17	35135142	35135142	p.R896C	c.2686C>T	Confirmed
GGA3	23163	hgsc.bcm.edu	36	17	70747108	70747108	+	Nonsense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-0906-01A-01W-0419-10	TCGA-13-0906-10A-01W-0419-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	17	70747108	70747108	T	A	SNP	GGA3	NM_138619	human	genbank	54_36p	-1	reviewed	nonsense	c.1723	p.K575*	0	NULL	"HMMPfam_VHS,superfamily_ENTH/VHS domain,HMMSmart_SM00288,superfamily_GAT-like domain,HMMPfam_GAT,superfamily_Clathrin adaptor appendage domain,HMMPfam_Alpha_adaptinC2,HMMSmart_SM00809"	-	no_errors	GGA3	17	70747110	70747110	p.P574L	c.1721C>T	Confirmed
ZNF286A	57335	hgsc.bcm.edu	36	17	15552269	15552269	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-25-1634-01A-01W-0615-10	TCGA-25-1634-10A-01W-0616-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	17	15552269	15552269	C	T	SNP	ZNF286A	NM_020652	human	genbank	54_36p	1	validated	missense	c.317	p.P106L	0.01	NULL	"superfamily_Krueppel-associated_box,HMMPfam_KRAB,HMMSmart_KRAB,superfamily_SSF57667,HMMPfam_zf-C2H2,HMMSmart_ZnF_C2H2,PatternScan_ZINC_FINGER_C2H2_1"	-	no_errors	ZNF286A	17	15552269	15552269	p.P106L	c.317C>T	Confirmed
FCGBP	8857	hgsc.bcm.edu	36	19	45100661	45100661	+	Missense_Mutation	SNP	C	G	G	rs45613437	Unknown	TCGA-25-1630-01A-01W-0615-10	TCGA-25-1630-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	19	45100661	45100661	C	G	SNP	FCGBP	NM_003890	human	genbank	54_36p	-1	validated	missense	c.4018	p.V1340L	0	"HMMSmart_VWD,HMMPfam_VWD"	"HMMSmart_FOLN,HMMSmart_VWD,HMMPfam_VWD,HMMPfam_C8,superfamily_Cysrich_TIL,HMMPfam_TIL,HMMPfam_TIL_assoc,HMMSmart_VWC"	-	no_errors	FCGBP	19	45100663	45100663	p.P1339H	c.4016C>A	Confirmed
KLK10	5655	hgsc.bcm.edu	36	19	56211177	56211177	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-36-1577-01A-01W-0615-10	TCGA-36-1577-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	19	56211177	56211177	C	A	SNP	KLK10	NM_001077500	human	genbank	54_36p	-1	reviewed	missense	c.317	p.G106V	0.83	"HMMSmart_SM00020,HMMPfam_Trypsin,superfamily_Trypsin-like serine proteases"	"HMMSmart_SM00020,HMMPfam_Trypsin,superfamily_Trypsin-like serine proteases,PatternScan_TRYPSIN_HIS"	-	no_errors	KLK10	19	56211178	56211178	p.G106R	c.316G>A	Confirmed
MAST1	22983	hgsc.bcm.edu	36	19	12823779	12823779	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-1408-01A-01W-0490-10	TCGA-13-1408-10A-01W-0491-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	19	12823779	12823779	C	A	SNP	MAST1	NM_014975	human	genbank	54_36p	1	provisional	missense	c.806	p.A269D	1	HMMPfam_DUF1908	"PatternScan_PROTEIN_KINASE_ATP,HMMPfam_DUF1908,superfamily_Kinase_like,HMMSmart_S_TKc,HMMPfam_Pkinase,PatternScan_PROTEIN_KINASE_ST,HMMSmart_S_TK_X,HMMPfam_Pkinase_C,superfamily_PDZ,HMMSmart_PDZ,HMMPfam_PDZ"	-	no_errors	MAST1	19	12823778	12823778	p.A269T	c.805G>A	Confirmed
PTPRS	5802	hgsc.bcm.edu	36	19	5173817	5173817	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-0919-01A-01W-0419-10	TCGA-13-0919-10A-01W-0419-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	19	5173817	5173817	T	C	SNP	PTPRS	NM_002850	human	genbank	54_36p	-1	reviewed	missense	c.2986	p.T996A	0.99	"superfamily_Fibronectin type III,HMMPfam_fn3,HMMSmart_SM00060"	###############################################################################################################################################################################################################################################################	-	no_errors	PTPRS	19	5173816	5173816	p.T996M	c.2987C>T	Confirmed
TSHZ3	57616	hgsc.bcm.edu	36	19	36462022	36462022	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-09-1661-01B-01W-0615-10	TCGA-09-1661-10A-01W-0616-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	19	36462022	36462022	C	T	SNP	TSHZ3	NM_020856	human	genbank	54_36p	-1	validated	missense	c.517	p.A173T	1	NULL	"PatternScan_HOMEOBOX_1,HMMPfam_zf-C2H2,HMMSmart_ZnF_C2H2,PatternScan_ZINC_FINGER_C2H2_1,superfamily_Homeodomain_like,HMMSmart_HOX,HMMPfam_Homeobox"	-	no_errors	TSHZ3	19	36461471	36461471	p.S173S	c.519C>T	Confirmed
ARFGEF2	10564	hgsc.bcm.edu	36	20	47038451	47038451	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-04-1364-01A-01W-0490-10	TCGA-04-1364-10A-01W-0490-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	20	47038451	47038451	C	G	SNP	ARFGEF2	NM_006420	human	genbank	54_36p	1	reviewed	missense	c.2378	p.T793R	1	"superfamily_ARM-type_fold,superfamily_Sec7,HMMPfam_Sec7,HMMSmart_Sec7"	"superfamily_ARM-type_fold,superfamily_Sec7,HMMPfam_Sec7,HMMSmart_Sec7,HMMPfam_DUF1981"	-	no_errors	ARFGEF2	20	47038453	47038453	p.K794E	c.2380A>G	Confirmed
BTBD3	22903	hgsc.bcm.edu	36	20	11851653	11851653	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0792-01A-01W-0370-10	TCGA-13-0792-10A-01W-0370-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	20	11851653	11851653	C	A	SNP	BTBD3	NM_014962	human	genbank	54_36p	1	validated	missense	c.908	p.A303E	0.04	NULL	"superfamily_BTB/POZ_fold,HMMPfam_BTB,HMMSmart_BTB,HMMPfam_PHR"	-	no_errors	BTBD3	20	11851652	11851652	p.A303T	c.907G>A	Confirmed
SMARCB1	6598	hgsc.bcm.edu	36	22	22505823	22505823	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0762-01A-01W-0370-10	TCGA-13-0762-10A-01W-0370-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	22	22505823	22505823	C	T	SNP	SMARCB1	NM_003073	human	genbank	54_36p	1	reviewed	missense	c.1051	p.P351S	1	HMMPfam_SNF5	HMMPfam_SNF5	-	no_errors	SMARCB1	22	22505823	22505826	p.P351fs*5	c.1051_1054delCCAC	Confirmed
SMARCB1	6598	hgsc.bcm.edu	36	22	22505875	22505875	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-13-0720-01A-01W-0370-10	TCGA-13-0720-10B-01W-0370-10	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	22	22505875	22505875	A	G	SNP	SMARCB1	NM_003073	human	genbank	54_36p	1	reviewed	missense	c.1103	p.Q368R	1	HMMPfam_SNF5	HMMPfam_SNF5	-	no_errors	SMARCB1	22	22505874	22505874	p.Q368*	c.1102C>T	Confirmed
SMARCB1	6598	hgsc.bcm.edu	36	22	22505888	22505888	+	Silent	SNP	G	G	A	novel	Unknown	TCGA-36-1571-01A-01W-0615-10	TCGA-36-1571-10A-01W-0615-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	22	22505888	22505888	G	A	SNP	SMARCB1	NM_003073	human	genbank	54_36p	1	reviewed	silent	c.1116	p.T372	0.98	HMMPfam_SNF5	HMMPfam_SNF5	-	no_errors	SMARCB1	22	22505888	22505888	p.T372T	c.1116G>A	Unknown
GSTM5	2949	broad.mit.edu	36	1	110059274	110059274	+	Splice_Site	SNP	G	G	A	novel	Unknown	TCGA-09-2051-01A-01W-0799-08	TCGA-09-2051-10A-01W-0799-08	G	G					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	1	110059274	110059274	G	A	SNP	GSTM5	NM_000851	human	genbank	54_36p	1	reviewed	splice_site	c.457-1	e7-1	1	-	-	-	no_errors	GSTM5	1	110059280	110059280	p.T154T	c.462C>T	Confirmed
NRAS	4893	broad.mit.edu	36	1	115058052	115058052	+	Missense_Mutation	SNP	T	T	C	rs11554290	by-hapmap	TCGA-61-2016-01A-01W-0722-08	TCGA-61-2016-10A-01W-0722-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	1	115058052	115058052	T	C	SNP	NRAS	NM_002524	human	genbank	54_36p	-1	reviewed	missense	c.182	p.Q61R	1	"HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases"	"HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases"	-	no_errors	NRAS	1	115058052	115058052	p.Q61R	c.182A>G	Confirmed
NRAS	4893	broad.mit.edu	36	1	115058052	115058052	+	Missense_Mutation	SNP	T	T	C	rs11554290	by-hapmap	TCGA-61-2095-01A-01W-0722-08	TCGA-61-2095-11A-01W-0723-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	1	115058052	115058052	T	C	SNP	NRAS	NM_002524	human	genbank	54_36p	-1	reviewed	missense	c.182	p.Q61R	1	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174"	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174"	-	no_errors	NRAS	1	115058052	115058052	p.Q61R	c.182A>G	Confirmed
TDRD5	163589	broad.mit.edu	36	1	177926529	177926529	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-61-1998-01A-01W-0722-08	TCGA-61-1998-10A-01W-0722-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	1	177926529	177926529	G	A	SNP	TDRD5	NM_173533	human	genbank	54_36p	1	provisional	missense	c.2774	p.R925H	0.01	NULL	"HMMSmart_SM00333,HMMPfam_TUDOR,superfamily_Tudor/PWWP/MBT"	-	no_errors	TDRD5	1	177926529	177926529	p.R925H	c.2774G>A	Confirmed
TPO	7173	broad.mit.edu	36	2	1467407	1467407	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-25-2409-01A-01W-0799-08	TCGA-25-2409-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	2	1467407	1467407	C	T	SNP	TPO	ENST00000308422	human	ensembl	54_36p	1	known	missense	c.391	p.P131S	1	NULL	"HMMPfam_An_peroxidase,superfamily_Heme-dependent peroxidases"	-	no_start_codon	TPO	2	1467407	1467407	p.I457I	c.1371C>T	Confirmed
MSH2	4436	broad.mit.edu	36	2	47558954	47558954	+	Frame_Shift_Del	DEL	G	-	G	novel	Unknown	TCGA-24-2288-01A-01W-0799-08	TCGA-24-2288-10A-01W-0799-08	G	G					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	2	47558954	47558954	G	-	DEL	MSH2	NM_000251	human	genbank	54_36p	1	reviewed	frame_shift_del	c.2250	p.G751fs	1	"HMMPfam_MutS_V,superfamily_SSF52540,HMMSmart_MUTSac,PatternScan_DNA_MISMATCH_REPAIR_2"	"HMMPfam_MutS_I,HMMPfam_MutS_II,HMMPfam_MutS_III,superfamily_DNA_repair_MutS_domIII,HMMSmart_MUTSd,HMMPfam_MutS_IV,HMMPfam_MutS_V,superfamily_SSF52540,HMMSmart_MUTSac,PatternScan_DNA_MISMATCH_REPAIR_2"	"(deletion:cds_exon[47558915,47559162])"	no_errors	MSH2	2	47558949	47558949	p.E749*	c.2245G>T	Confirmed
ACVR1C	130399	broad.mit.edu	36	2	158107611	158107612	+	Missense_Mutation	DNP	GC	GC	AA	novel	Unknown	TCGA-61-2094-01A-01W-0722-08	TCGA-61-2094-11A-01W-0722-08	GC	GC					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	2	158107611	158107612	GC	AA	DNP	ACVR1C	NM_145259	human	genbank	54_36p	-1	validated	missense	c.953_952	p.A318F	1.000:1.000	"superfamily_Protein kinase-like (PK-like),HMMSmart_SM00220,HMMSmart_SM00219,HMMPfam_Pkinase"	"superfamily_Snake toxin-like,HMMPfam_Activin_recp,HMMPfam_TGF_beta_GS,HMMSmart_SM00467,superfamily_Protein kinase-like (PK-like),HMMSmart_SM00220,HMMSmart_SM00219,HMMPfam_Pkinase,PatternScan_PROTEIN_KINASE_ATP,PatternScan_PROTEIN_KINASE_ST"	-	no_errors	ACVR1C	2	158107608	158107608	p.I319N	c.956T>A	Confirmed
MYO3B	140469	broad.mit.edu	36	2	170948469	170948498	+	In_Frame_Del	DEL	TCCAGACTTTATCATGGGGTGAAACGCGCC	-	TCCAGACTTTATCATGGGGTGAAACGCGCC	novel	Unknown	TCGA-13-0913-01A-01W	TCGA-13-0913-10A-01D	TCCAGACTTTATCATGGGGTGAAACGCGCC	TCCAGACTTTATCATGGGGTGAAACGCGCC	-	-	TCCAGACTTTATCATGGGGTGAAACGCGCC	TCCAGACTTTATCATGGGGTGAAACGCGCC	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	2	170948469	170948498	TCCAGACTTTATCATGGGGTGAAACGCGCC	-	DEL	MYO3B	NM_138995	human	genbank	54_36p	1	provisional	in_frame_del	c.1189_1218	p.RLYHGVKRAS398in_frame_del	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.990:1.000:1.000:1.000:1.000:1.000:0.999:1.000:1.000:0.993:0.998:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.988:0.993:0.997:0.997	"superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00242,HMMPfam_Myosin_head"	###############################################################################################################################################################################################################################################################	"(deletion:cds_exon[170948466,170948570])"	no_errors	MYO3B	2	170948494	170948494	p.R405L	c.1214G>T	Confirmed
SP100	6672	broad.mit.edu	36	2	231077183	231077183	+	Nonsense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-24-1419-01A-01W	TCGA-24-1419-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	2	231077183	231077183	C	T	SNP	SP100	NM_001080391	human	genbank	54_36p	1	validated	nonsense	c.1804	p.Q602*	0	"HMMPfam_SAND,superfamily_SAND domain-like"	"HMMPfam_SAND,HMMSmart_SM00258,HMMPfam_Bromodomain,HMMSmart_SM00297,superfamily_Bromodomain,HMMSmart_SM00249,HMMPfam_Sp100,superfamily_SAND domain-like,superfamily_FYVE/PHD zinc finger,PatternScan_ZF_PHD_1,HMMPfam_PHD"	-	no_errors	SP100	2	231077184	231077184	p.Q602L	c.1805A>T	Confirmed
MLH1	4292	broad.mit.edu	36	3	37017540	37017540	+	Nonsense_Mutation	SNP	C	C	T	rs63751221	Unknown	TCGA-13-1492-01A-01D	TCGA-13-1492-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	3	37017540	37017540	C	T	SNP	MLH1	NM_000249	human	genbank	54_36p	1	reviewed	nonsense	c.298	p.R100*	1	"superfamily_ATP_bd_ATPase,HMMPfam_HATPase_c,HMMSmart_HATPase_c,PatternScan_DNA_MISMATCH_REPAIR_1"	"superfamily_ATP_bd_ATPase,HMMPfam_HATPase_c,HMMSmart_HATPase_c,PatternScan_DNA_MISMATCH_REPAIR_1,superfamily_Ribosomal_S5_D2-typ_fold,HMMPfam_DNA_mis_repair"	-	no_errors	MLH1	3	37017540	37017540	p.R100*	c.298C>T	Unknown
GNAT1	2779	broad.mit.edu	36	3	50205602	50205602	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-25-2391-01A-01W-0799-08	TCGA-25-2391-10A-01W-0799-08	A	A					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	3	50205602	50205602	A	C	SNP	GNAT1	NM_000172	human	genbank	54_36p	1	reviewed	missense	c.139	p.K47Q	1	"superfamily_SSF52540,HMMPfam_G-alpha"	"superfamily_SSF52540,HMMPfam_G-alpha,superfamily_Transducn_insert"	-	no_errors	GNAT1	3	50205604	50205604	p.K47K	c.141G>A	Confirmed
HTR3C	170572	broad.mit.edu	36	3	185256761	185256761	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-61-2012-01A-01W-0722-08	TCGA-61-2012-11A-01W-0722-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	3	185256761	185256761	G	A	SNP	HTR3C	NM_130770	human	genbank	54_36p	1	reviewed	missense	c.382	p.V128M	0.29	"superfamily_Neur_chan_LBD,HMMPfam_Neur_chan_LBD"	"superfamily_Neur_chan_LBD,HMMPfam_Neur_chan_LBD,PatternScan_NEUROTR_ION_CHANNEL,superfamily_Neu_channel_TM,HMMPfam_Neur_chan_memb"	-	no_errors	HTR3C	3	185256761	185256761	p.V128M	c.382G>A	Confirmed
TP63	8626	broad.mit.edu	36	3	191068418	191068418	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-59-2351-01A-01W-0799-08	TCGA-59-2351-10A-01W-0800-08	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	3	191068418	191068418	A	C	SNP	TP63	NM_003722	human	genbank	54_36p	1	reviewed	missense	c.985	p.T329P	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"HMMSmart_SM00454,PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,superfamily_SAM/Pointed domain,HMMPfam_SAM_2,HMMPfam_P53"	-	no_errors	TP63	3	191068415	191068415	p.E328*	c.982G>T	Confirmed
MTTP	4547	broad.mit.edu	36	4	100746944	100746944	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-61-2012-01A-01W-0722-08	TCGA-61-2012-11A-01W-0722-08	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	4	100746944	100746944	A	G	SNP	MTTP	NM_000253	human	genbank	54_36p	1	reviewed	missense	c.1361	p.K454R	1	"HMMPfam_Vitellogenin_N,HMMSmart_LPD_N,superfamily_LV_superhelical"	"superfamily_Lipid_transp_b-sht_shell,HMMPfam_Vitellogenin_N,HMMSmart_LPD_N,superfamily_LV_superhelical"	-	no_errors	MTTP	4	100746945	100746945	p.K454K	c.1362G>A	Confirmed
APC	324	broad.mit.edu	36	5	112203476	112203476	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-2024-01A-02W-0722-08	TCGA-24-2024-11A-01W-0722-08	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	5	112203476	112203476	A	G	SNP	APC	NM_000038	human	genbank	54_36p	1	reviewed	missense	c.4286	p.Q1429R	1	NULL	"HMMPfam_Arm,HMMSmart_SM00185,HMMPfam_APC_crr,HMMPfam_SAMP,HMMPfam_EB1_binding,HMMPfam_APC_basic,HMMPfam_APC_15aa,superfamily_ARM repeat"	-	no_errors	APC	5	112203476	112203476	p.T1430fs*43	c.4286delA	Confirmed
APC	324	broad.mit.edu	36	5	112204836	112204836	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-61-1919-01A-01W-0699-08	TCGA-61-1919-11A-01W-0700-08	A	A					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	5	112204836	112204836	A	T	SNP	APC	NM_000038	human	genbank	54_36p	1	reviewed	missense	c.5646	p.R1882S	1	NULL	"HMMPfam_Arm,HMMSmart_SM00185,HMMPfam_APC_crr,HMMPfam_SAMP,HMMPfam_EB1_binding,HMMPfam_APC_basic,HMMPfam_APC_15aa,superfamily_ARM repeat"	-	no_errors	APC	5	112144417	112144424	p.Q188fs*2	c.563_570delAATTGGAA	Confirmed
ARAP3	64411	broad.mit.edu	36	5	141032024	141032024	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-1484-01A-01W	TCGA-13-1484-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	5	141032024	141032024	G	A	SNP	ARAP3	NM_022481	human	genbank	54_36p	-1	reviewed	nonsense	c.1414	p.Q472*	1	"superfamily_SSF50729,HMMPfam_PH,HMMSmart_PH"	"HMMSmart_SAM,superfamily_SAM_homology,HMMPfam_SAM_2,superfamily_SSF50729,HMMPfam_PH,HMMSmart_PH,superfamily_ArfGAP,HMMPfam_ArfGap,HMMSmart_ArfGap,superfamily_Rho_GAP,HMMSmart_RhoGAP,HMMPfam_RhoGAP,HMMPfam_RA"	-	no_errors	ARAP3	5	141032027	141032027	p.R471W	c.1411C>T	Confirmed
BAI3	577	broad.mit.edu	36	6	70127958	70127958	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-23-1110-01A-01D	TCGA-23-1110-10A-01D	C	C					Unknown	Unknown	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	6	70127958	70127958	C	A	SNP	BAI3	NM_001704	human	genbank	54_36p	1	reviewed	missense	c.4072	p.Q1358K	1	NULL	"HMMPfam_GPS,HMMSmart_SM00303,HMMPfam_7tm_2,HMMPfam_TSP_1,HMMSmart_SM00209,superfamily_TSP-1 type 1 repeat,HMMPfam_HRM,HMMSmart_SM00008,PatternScan_G_PROTEIN_RECEP_F2_2"	-	no_errors	BAI3	6	70127963	70127963	p.F1359F	c.4077C>T	Confirmed
EPHA7	2045	broad.mit.edu	36	6	94177155	94177155	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1434-01A-01W	TCGA-24-1434-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture;Sequenom			Illumina GAIIx	6	94177155	94177155	C	A	SNP	EPHA7	NM_004440	human	genbank	54_36p	-1	reviewed	missense	c.617	p.W206L	1	PatternScan_RECEPTOR_TYR_KIN_V_1	###############################################################################################################################################################################################################################################################	-	no_errors	EPHA7	6	94177152	94177152	p.S207F	c.620C>T	Confirmed
EGFR	1956	broad.mit.edu	36	7	55209193	55209193	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-2289-01A-01W-0799-08	TCGA-24-2289-10A-01W-0799-08	A	A					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	7	55209193	55209193	A	G	SNP	EGFR	NM_005228	human	genbank	54_36p	1	reviewed	missense	c.2147	p.K716R	1	"HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like)"	###############################################################################################################################################################################################################################################################	-	no_errors	EGFR	7	55209190	55209190	p.I715S	c.2144T>G	Unknown
CALCR	799	broad.mit.edu	36	7	92946683	92946683	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-25-1319-01A-01W	TCGA-25-1319-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	7	92946683	92946683	C	T	SNP	CALCR	NM_001742	human	genbank	54_36p	-1	validated	missense	c.124	p.V42I	0	superfamily_SSF111418	"HMMPfam_7tm_2,HMMPfam_HRM,HMMSmart_HormR,PatternScan_G_PROTEIN_RECEP_F2_1,PatternScan_G_PROTEIN_RECEP_F2_2,superfamily_SSF111418,superfamily_SSF81321"	-	no_errors	CALCR	7	92946684	92946684	p.Y41*	c.123C>G	Confirmed
SPAM1	6677	broad.mit.edu	36	7	123380877	123380877	+	Missense_Mutation	SNP	T	T	G	novel	Unknown	TCGA-24-0975-01B-02W	TCGA-24-0975-10B-01W	T	T	G	G	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture;Sequenom			Illumina GAIIx	7	123380877	123380877	T	G	SNP	SPAM1	NM_003117	human	genbank	54_36p	1	reviewed	missense	c.17	p.F6C	0	NULL	"HMMPfam_Glyco_hydro_56,superfamily_Glyco_hydro_cat"	-	no_errors	SPAM1				p.K5Q	c.13A>C	Confirmed
BRAF	673	broad.mit.edu	36	7	140099662	140099662	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1565-01A-01W	TCGA-24-1565-10A-01W	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	7	140099662	140099662	T	C	SNP	BRAF	NM_004333	human	genbank	54_36p	-1	reviewed	missense	c.1742	p.N581S	1	"superfamily_Protein kinase-like (PK-like),HMMSmart_SM00219,HMMPfam_Pkinase,HMMSmart_SM00220,PatternScan_PROTEIN_KINASE_ST"	###############################################################################################################################################################################################################################################################	-	no_errors	BRAF	7	140099662	140099662	p.N581S	c.1742A>G	Confirmed
TRPV5	56302	broad.mit.edu	36	7	142332804	142332804	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0913-01A-01W	TCGA-13-0913-10A-01D	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	7	142332804	142332804	C	A	SNP	TRPV5	NM_019841	human	genbank	54_36p	-1	reviewed	missense	c.1064	p.R355L	0.1	NULL	"superfamily_Ankyrin repeat,HMMSmart_SM00248,HMMPfam_Ank,HMMPfam_Ion_trans"	-	no_errors	TRPV5	7	142332804	142332804	p.R355H	c.1064G>A	Confirmed
ROR2	4920	broad.mit.edu	36	9	93526859	93526859	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1419-01A-01W	TCGA-24-1419-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	9	93526859	93526859	C	A	SNP	ROR2	NM_004560	human	genbank	54_36p	-1	reviewed	missense	c.1738	p.D580Y	1	"superfamily_Kinase_like,HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc"	"PatternScan_PROTEIN_KINASE_ATP,superfamily_SSF48726,HMMPfam_I-set,HMMSmart_IGc2,HMMPfam_Fz,superfamily_Kringle-like,HMMSmart_KR,HMMPfam_Kringle,PatternScan_KRINGLE_1,superfamily_Kinase_like,HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc,PatternScan_PROTEIN_KINASE_TYR"	-	no_errors	ROR2	9	93526856	93526856	p.R581G	c.1741C>G	Confirmed
NOTCH1	4851	broad.mit.edu	36	9	138511033	138511033	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-61-2012-01A-01W-0722-08	TCGA-61-2012-11A-01W-0722-08	G	G					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	9	138511033	138511033	G	A	SNP	NOTCH1	NM_017617	human	genbank	54_36p	-1	reviewed	missense	c.6979	p.R2327W	0.99	NULL	###############################################################################################################################################################################################################################################################	-	no_errors	NOTCH1	9	138511033	138511033	p.R2328W	c.6982C>T	Confirmed
PRKG1	5592	broad.mit.edu	36	10	53492301	53492301	+	Splice_Site	SNP	A	A	T	novel	Unknown	TCGA-25-1313-01A-01W	TCGA-25-1313-10A-01W	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	10	53492301	53492301	A	T	SNP	PRKG1	NM_006258	human	genbank	54_36p	1	validated	splice_site	c.841-2	e7-2	0.99	-	-	-	no_errors	PRKG1	10	53484327	53484327	p.T280T	c.840G>A	Confirmed
PTEN	5728	broad.mit.edu	36	10	89707652	89707652	+	Frame_Shift_Del	DEL	C	-	-	novel	Unknown	TCGA-13-1492-01A-01D	TCGA-13-1492-10A-01W	C	C	-	-	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	10	89707652	89707652	C	-	DEL	PTEN	NM_000314	human	genbank	54_36p	1	reviewed	frame_shift_del	c.697	p.R233fs	1	"HMMPfam_PTEN_C2,superfamily_C2 domain (Calcium/lipid-binding domain CaLB)"	"superfamily_(Phosphotyrosine protein) phosphatases II,HMMSmart_SM00404,PatternScan_TYR_PHOSPHATASE_1,HMMPfam_DSPc,HMMPfam_PTEN_C2,superfamily_C2 domain (Calcium/lipid-binding domain CaLB)"	"(deletion:cds_exon[89707590,89707756])"	no_errors	PTEN	10	89707652	89707652	p.R233*	c.697C>T	Confirmed
ACCS	84680	broad.mit.edu	36	11	44055977	44055977	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-09-2056-01B-01W-0722-08	TCGA-09-2056-11A-01W-0722-08	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	11	44055977	44055977	G	C	SNP	ACCS	NM_032592	human	genbank	54_36p	1	validated	missense	c.661	p.G221R	0.66	"superfamily_PyrdxlP-dep_Trfase_major,HMMPfam_Aminotran_1_2"	"PatternScan_AA_TRANSFER_CLASS_1,superfamily_PyrdxlP-dep_Trfase_major,HMMPfam_Aminotran_1_2"	-	no_errors	ACCS	11	44055978	44055978	p.G221E	c.662G>A	Confirmed
OR5J2	282775	broad.mit.edu	36	11	55701170	55701170	+	Silent	SNP	C	C	G	novel	Unknown	TCGA-59-2354-01A-01W-0799-08	TCGA-59-2354-11A-01W-0800-08	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	11	55701170	55701170	C	G	SNP	OR5J2	NM_001005492	human	genbank	54_36p	1	provisional	silent	c.501	p.S167	0.01	"superfamily_SSF81321,HMMPfam_7tm_1"	"superfamily_SSF81321,HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1"	-	no_errors	OR5J2	11	55701170	55701170	p.S167S	c.501C>G	Confirmed
CASP5	838	broad.mit.edu	36	11	104383020	104383020	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-2293-01A-01W-0799-08	TCGA-24-2293-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	11	104383020	104383020	G	A	SNP	CASP5	NM_004347	human	genbank	54_36p	-1	reviewed	missense	c.385	p.P129S	0.07	"HMMSmart_CARD,superfamily_DEATH_like,HMMPfam_CARD"	"HMMSmart_CARD,superfamily_DEATH_like,HMMPfam_CARD,superfamily_SSF52129,HMMSmart_CASc,HMMPfam_Peptidase_C14,PatternScan_CASPASE_HIS,PatternScan_CASPASE_CYS"	-	no_errors	CASP5	11	104379318	104379318	p.L130V	c.388C>G	Confirmed
KRAS	3845	broad.mit.edu	36	12	25289551	25289551	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-2038-01A-01W-0722-08	TCGA-24-2038-10A-01W-0722-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	12	25289551	25289551	C	A	SNP	KRAS	NM_033360	human	genbank	54_36p	-1	reviewed	missense	c.35	p.G12V	1	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	-	no_errors	KRAS	12	25289551	25289551	p.G12D	c.35G>A	Previously Observed
CDK17	5128	broad.mit.edu	36	12	95212971	95212971	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-1510-01A-02D	TCGA-13-1510-10A-01W	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	12	95212971	95212971	G	C	SNP	PCTK2	NM_002595	human	genbank	54_36p	-1	reviewed	missense	c.934	p.R312G	1	"HMMSmart_SM00219,HMMSmart_SM00220,PatternScan_PROTEIN_KINASE_ST,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase"	"HMMSmart_SM00219,HMMSmart_SM00220,PatternScan_PROTEIN_KINASE_ST,superfamily_Protein kinase-like (PK-like),PatternScan_PROTEIN_KINASE_ATP,HMMPfam_Pkinase"	-	no_errors	CDK17	12	95212971	95212971	p.R312G	c.934C>G	Confirmed
JAK3	3718	broad.mit.edu	36	19	17811423	17811423	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-2396-01A-01W-0799-08	TCGA-25-2396-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	19	17811423	17811423	G	A	SNP	JAK3	NM_000215	human	genbank	54_36p	-1	reviewed	missense	c.1304	p.T435I	0	"superfamily_SH2 domain,HMMSmart_SM00252"	"HMMSmart_SM00295,superfamily_SH2 domain,HMMSmart_SM00252,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,PatternScan_THIOL_PROTEASE_HIS,PatternScan_PROTEIN_KINASE_ATP,PatternScan_PROTEIN_KINASE_TYR"	-	no_errors	JAK3	19	17811426	17811426	p.P434R	c.1301C>G	Unknown
DYRK1B	9149	broad.mit.edu	36	19	45013011	45013011	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-23-2077-01A-01W-0722-08	TCGA-23-2077-10A-01W-0722-08	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	19	45013011	45013011	C	G	SNP	DYRK1B	NM_004714	human	genbank	54_36p	-1	reviewed	missense	c.216	p.Q72H	1	NULL	"HMMSmart_SM00219,HMMSmart_SM00220,PatternScan_PROTEIN_KINASE_ST,superfamily_Protein kinase-like (PK-like),PatternScan_PROTEIN_KINASE_ATP,HMMPfam_Pkinase"	-	no_errors	DYRK1B	19	45013014	45013014	p.A71A	c.213C>T	Confirmed
GSK3A	2931	broad.mit.edu	36	19	47428573	47428573	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-61-2109-01A-01W-0722-08	TCGA-61-2109-11A-01W-0723-08	G	G					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	19	47428573	47428573	G	C	SNP	GSK3A	NM_019884	human	genbank	54_36p	-1	validated	missense	c.1200	p.H400Q	1	"HMMSmart_S_TKc,superfamily_Kinase_like,HMMPfam_Pkinase"	"HMMSmart_S_TKc,PatternScan_PROTEIN_KINASE_ST,superfamily_Kinase_like,PatternScan_PROTEIN_KINASE_ATP,HMMPfam_Pkinase"	-	no_errors	GSK3A	19	47428574	47428574	p.H400R	c.1199A>G	Confirmed
PPP2R1A	5518	broad.mit.edu	36	19	57407794	57407794	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-61-2111-01A-01W-0722-08	TCGA-61-2111-11A-01W-0723-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	19	57407794	57407794	C	T	SNP	PPP2R1A	NM_014225	human	genbank	54_36p	1	reviewed	missense	c.547	p.R183W	1	"HMMPfam_HEAT,superfamily_ARM repeat"	"HMMPfam_HEAT,superfamily_ARM repeat"	-	no_errors	PPP2R1A	19	57407794	57407794	p.R183G	c.547C>G	Previously Observed
PIWIL3	440822	broad.mit.edu	36	22	23445513	23445513	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-25-1326-01A-01W	TCGA-25-1326-10A-01W	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	22	23445513	23445513	G	C	SNP	PIWIL3	NM_001008496	human	genbank	54_36p	-1	validated	missense	c.2575	p.L859V	1	"superfamily_RNaseH_fold,HMMPfam_Piwi"	"superfamily_SSF101690,HMMPfam_PAZ,superfamily_RNaseH_fold,HMMPfam_Piwi"	-	no_errors	PIWIL3	22	23445509	23445509	p.A860V	c.2579C>T	Confirmed
ARMCX3	51566	broad.mit.edu	36	X	100767422	100767422	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-04-1356-01A-01W	TCGA-04-1356-11A-01W	T	T					Unknown	Unknown	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	X	100767422	100767422	T	A	SNP	ARMCX3	NM_016607	human	genbank	54_36p	1	reviewed	missense	c.797	p.L266H	1	"HMMPfam_DUF634,superfamily_ARM-type_fold"	"HMMPfam_DUF634,superfamily_ARM-type_fold"	-	no_errors	ARMCX3	23	100767424	100767424	p.L267F	c.799C>T	Confirmed
RB1	5925	genome.wustl.edu	36	13	47853541	47853556	+	Frame_Shift_Del	DEL	ATGTGAACATCGAATC	ATGTGAACATCGAATC	-	novel	Unknown	TCGA-24-1463-01A-01W-0549-09	TCGA-24-1463-10A-01W-0549-09	ATGTGAACATCGAATC	ATGTGAACATCGAATC	ATGTGAACATCGAATC	-	ATGTGAACATCGAATC	ATGTGAACATCGAATC	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	13	47853541	47853556	ATGTGAACATCGAATC	-	DEL	RB1	NM_000321	human	genbank	54_36p	1	reviewed	frame_shift_del	c.1656_1671	p.C553fs	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.999:1.000:1.000:1.000	"HMMPfam_RB_A,superfamily_Cyclin-like"	"HMMPfam_RB_A,superfamily_Cyclin-like,HMMPfam_RB_B,HMMSmart_SM00385,HMMPfam_Rb_C"	"(deletion:cds_exon[47853384,47853580])"	no_errors	RB1	13	47853551	47853551	p.R556*	c.1666C>T	Confirmed
RB1	5925	genome.wustl.edu	36	13	47931968	47931968	+	Missense_Mutation	SNP	C	A	A	novel	Unknown	TCGA-13-1489-01A-01W-0549-09	TCGA-13-1489-10A-01W-0549-09	C	C	A	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	13	47931968	47931968	C	A	SNP	RB1	NM_000321	human	genbank	54_36p	1	reviewed	missense	c.2104	p.Q702K	1	"HMMPfam_RB_B,HMMSmart_SM00385,superfamily_Cyclin-like"	"HMMPfam_RB_B,HMMPfam_RB_A,HMMSmart_SM00385,superfamily_Cyclin-like,HMMPfam_Rb_C"	-	no_errors	RB1	13	47931968	47931968	p.Q702*	c.2104C>T	Confirmed
RB1	5925	genome.wustl.edu	36	13	47937375	47937375	+	Nonsense_Mutation	SNP	C	T	T	novel	Unknown	TCGA-10-0933-01A-01W-0421-09	TCGA-10-0933-11A-01W-0421-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	13	47937375	47937375	C	T	SNP	RB1	NM_000321	human	genbank	54_36p	1	reviewed	nonsense	c.2359	p.R787*	1	HMMPfam_Rb_C	"HMMPfam_RB_B,HMMPfam_RB_A,HMMSmart_SM00385,superfamily_Cyclin-like,HMMPfam_Rb_C"	-	no_errors	RB1	13	47937375	47937375	p.R787*	c.2359C>T	Previously Observed
RB1	5925	genome.wustl.edu	36	13	47937406	47937422	+	Frame_Shift_Del	DEL	TACGGATTCCTGGAGGG	TACGGATTCCTGGAGGG	-	novel	Unknown	TCGA-13-1509-01A-01W-0549-09	TCGA-13-1509-10A-01W-0550-09	TACGGATTCCTGGAGGG	TACGGATTCCTGGAGGG	TACGGATTCCTGGAGGG	-	TACGGATTCCTGGAGGG	TACGGATTCCTGGAGGG	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	13	47937406	47937422	TACGGATTCCTGGAGGG	-	DEL	RB1	NM_000321	human	genbank	54_36p	1	reviewed	frame_shift_del	c.2390_2406	p.L797fs	0.997:0.978:1.000:1.000:0.968:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.958:0.443:0.994:1.000:0.997	HMMPfam_Rb_C	"HMMPfam_RB_B,HMMPfam_RB_A,HMMSmart_SM00385,superfamily_Cyclin-like,HMMPfam_Rb_C"	"(deletion:cds_exon[47937342,47937505])"	no_errors	RB1	13	47937408	47937408	p.R798W	c.2392C>T	Unknown
NF1	4763	genome.wustl.edu	36	17	26510201	26510219	+	Frame_Shift_Del	DEL	GATTATATTGGATACACTG	GATTATATTGGATACACTG	-	novel	Unknown	TCGA-24-1463-01A-01W-0549-09	TCGA-24-1463-10A-01W-0549-09	GATTATATTGGATACACTG	GATTATATTGGATACACTG	GATTATATTGGATACACTG	-	GATTATATTGGATACACTG	GATTATATTGGATACACTG	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	26510201	26510219	GATTATATTGGATACACTG	-	DEL	NF1	NM_001042492	human	genbank	54_36p	1	reviewed	frame_shift_del	c.252_270	p.I85fs	1.000:1.000:1.000:1.000:1.000:1.000:0.998:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000	NULL	"HMMSmart_SM00323,superfamily_GTPase activation domain GAP,HMMPfam_RasGAP,PatternScan_RAS_GTPASE_ACTIV_1,HMMSmart_SM00516"	"(deletion:cds_exon[26510154,26510237])"	no_errors	NF1	17	26510220	26510220	p.E91K	c.271G>A	Confirmed
NF1	4763	genome.wustl.edu	36	17	26686014	26686032	+	Frame_Shift_Del	DEL	ATGACTCCATGGCTGTCAA	ATGACTCCATGGCTGTCAA	-	novel	Unknown	TCGA-24-1470-01A-01W-0553-09	TCGA-24-1470-10A-01W-0553-09	ATGACTCCATGGCTGTCAA	ATGACTCCATGGCTGTCAA	ATGACTCCATGGCTGTCAA	-	ATGACTCCATGGCTGTCAA	ATGACTCCATGGCTGTCAA	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	26686014	26686032	ATGACTCCATGGCTGTCAA	-	DEL	NF1	NM_001042492	human	genbank	54_36p	1	reviewed	frame_shift_del	c.5845_5863	p.M1949fs	1.000:1.000:1.000:1.000:1.000:0.999:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.993:0.953:1.000	NULL	"HMMSmart_SM00516,HMMPfam_RasGAP,HMMSmart_SM00323,PatternScan_RAS_GTPASE_ACTIV_1,superfamily_GTPase activation domain GAP"	"(deletion:cds_exon[26685982,26686175])"	no_errors	NF1	17	26686020	26686020	p.P1951fs*6	c.5851delC	Confirmed
TP53	7157	genome.wustl.edu	36	17	7514728	7514728	+	Nonsense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-13-1489-01A-01W-0549-09	TCGA-13-1489-10A-01W-0549-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7514728	7514728	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.1024	p.R342*	0.4	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"HMMPfam_P53_TAD,HMMPfam_P53,superfamily_p53-like transcription factors,PatternScan_P53,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	-	no_errors	TP53	17	7514728	7514728	p.R342*	c.1024C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7514728	7514728	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0884-01B-01W-0494-09	TCGA-13-0884-10A-01W-0494-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7514728	7514728	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.1024	p.R342*	0.4	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7514728	7514728	p.R342*	c.1024C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7514755	7514755	+	Frame_Shift_Del	DEL	G	G	-	novel	Unknown	TCGA-13-1497-01A-01W-0549-09	TCGA-13-1497-10A-01W-0549-09	G	G	G	-	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7514755	7514755	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.997	p.R333fs	0.03	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7514652,7514758])"	no_errors	TP53	17	7514758	7514758	p.I332V	c.994A>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7514759	7514759	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-13-1498-01A-01W-0549-09	TCGA-13-1498-10A-01W-0549-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7514759	7514759	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.994-1	e9-1	1	-	-	-	no_errors	TP53	17	7514759	7514759	p.?	c.994-1G>C	Unknown
TP53	7157	genome.wustl.edu	36	17	7517577	7517577	+	Splice_Site	SNP	C	C	G	novel	Unknown	TCGA-24-1436-01A-01W-0549-09	TCGA-24-1436-10A-01W-0549-09	C	C					Verified	Unknown	Somatic	Phase_III	PCR	Sanger_PCR_WGA		dbGAP	ABI 3730xl	17	7517577	7517577	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.993+1	e8+1	0.99	-	-	-	no_errors	TP53	17	7517577	7517577	p.?	c.993+1G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7517583	7517583	+	Frame_Shift_Del	DEL	G	G	-	novel	Unknown	TCGA-13-1509-01A-01W-0549-09	TCGA-13-1509-10A-01W-0550-09	G	G	G	-	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517583	7517583	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.988	p.L330fs	1	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7517578,7517651])"	no_errors	TP53	17	7517584	7517584	p.T329T	c.987C>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7517743	7517743	+	Splice_Site	SNP	C	T	T	novel	Unknown	TCGA-24-1103-01A-01W-0488-09	TCGA-24-1103-10A-01W-0488-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517743	7517743	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.919+1	e7+1	1	-	-	-	no_errors	TP53	17	7517743	7517743	p.?	c.919+1G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7517747	7517747	+	Nonsense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-13-1488-01A-01W-0549-09	TCGA-13-1488-10A-01W-0549-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517747	7517747	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.916	p.R306*	1	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517747	7517747	p.R306*	c.916C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517747	7517747	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-1483-01A-01W-0549-09	TCGA-13-1483-10A-01W-0549-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517747	7517747	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.916	p.R306*	1	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517747	7517747	p.R306*	c.916C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	A	A	rs28934574	Unknown	TCGA-24-1416-01A-01W-0549-09	TCGA-24-1416-10A-01W-0549-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517819	7517819	p.R282W	c.844C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-13-0726-01A-01W-0372-09	TCGA-13-0726-10B-01W-0977-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517819	7517819	p.R282W	c.844C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517824	7517824	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-1482-01A-01W-0549-09	TCGA-13-1482-10A-01W-0549-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517824	7517824	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.839	p.R280I	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517824	7517824	p.R280K	c.839G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7517833	7517833	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-1411-01A-01W-0494-09	TCGA-13-1411-10A-01W-0495-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517833	7517833	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.830	p.C277F	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517833	7517833	p.C277F	c.830G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7517837	7517837	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-13-0807-01B-02W-0421-09	TCGA-13-0807-10A-01W-0421-09	C	C	C	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517837	7517837	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.826	p.A276P	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517837	7517837	p.A276T	c.826G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7517839	7517839	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0910-01A-01W-0421-09	TCGA-13-0910-10A-01W-0421-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517839	7517839	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.824	p.C275Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517839	7517839	p.C275F	c.824G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7517839	7517839	+	Missense_Mutation	SNP	C	T	T	novel	Unknown	TCGA-13-1491-01A-01W-0549-09	TCGA-13-1491-10A-01W-0549-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517839	7517839	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.824	p.C275Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517839	7517839	p.C275F	c.824G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7517842	7517842	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-24-1463-01A-01W-0549-09	TCGA-24-1463-10A-01W-0549-09	A	A	A	T	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517842	7517842	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.821	p.V274D	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517842	7517842	p.V274A	c.821T>C	Unknown
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	A	A	rs28934576	Unknown	TCGA-13-0791-01A-01W-0372-09	TCGA-13-0791-10A-01W-0372-09	C	C	A	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273L	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-04-1542-01A-01W-0553-09	TCGA-04-1542-10A-01W-0553-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-13-0804-01A-01W-0372-09	TCGA-13-0804-10A-01W-0372-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-25-1315-01A-01W-0494-09	TCGA-25-1315-10A-01W-0494-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-24-1426-01A-01W-0549-09	TCGA-24-1426-10A-01W-0549-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517846	7517846	p.R273C	c.817C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-1499-01A-01W-0549-09	TCGA-13-1499-10A-01W-0549-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	"454_PCR_WGA,Sanger_PCR_WGA"		dbGAP	Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517846	7517846	p.R273C	c.817C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517849	7517849	+	Frame_Shift_Del	DEL	C	C	-	novel	Unknown	TCGA-24-1427-01A-01W-0549-09	TCGA-24-1427-10A-01W-0549-09	C	C	C	-	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517849	7517849	C	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.814	p.V272fs	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7517744,7517880])"	no_errors	TP53	17	7517849	7517849	p.V272fs*73	c.814delG	Unknown
TP53	7157	genome.wustl.edu	36	17	7517853	7517853	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-13-0924-01A-01W-0421-09	TCGA-13-0924-10A-01W-0421-09	A	A	A	C	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517853	7517853	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.810	p.F270L	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517853	7517853	p.F270L	c.810T>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7517867	7517867	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-04-1348-01A-01W-0494-09	TCGA-04-1348-11A-01W-0494-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517867	7517867	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.796	p.G266R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517867	7517867	p.G266R	c.796G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7517869	7517869	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-13-0760-01A-01W-0372-09	TCGA-13-0760-10A-01W-0372-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA		dbGAP	Illumina GAIIx	17	7517869	7517869	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.794	p.L265P	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517869	7517869	p.L265P	c.794T>C	Unknown
TP53	7157	genome.wustl.edu	36	17	7517871	7517872	+	In_Frame_Ins	INS	-	-	AGATTACCACTACTC	novel	Unknown	TCGA-13-0765-01A-01W-0372-09	TCGA-13-0765-10A-01W-0372-09	-	-	-	AGATTACCACTACTC	-	-	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517871	7517872	-	AGATTACCACTACTC	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_ins	c.792_791	p.265in_frame_insSSGNL	0.348:0.418	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517871	7517870	p.L265fs*81	c.792_793insNN	Unknown
TP53	7157	genome.wustl.edu	36	17	7518223	7518223	+	Splice_Site	SNP	C	T	T	novel	Unknown	TCGA-13-0912-01A-01W-0421-09	TCGA-13-0912-10A-01W-0421-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518223	7518223	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.782+1	e6+1	1	-	-	-	no_errors	TP53	17	7518223	7518223	p.?	c.782+1G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7518226	7518226	+	Frame_Shift_Del	DEL	G	G	-	novel	Unknown	TCGA-24-1470-01A-01W-0553-09	TCGA-24-1470-10A-01W-0553-09	G	G	G	-	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518226	7518226	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.780	p.S261fs	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	17	7518226	7518226	p.S261fs*84	c.780delC	Unknown
TP53	7157	genome.wustl.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	Unknown	TCGA-13-1499-01A-01W-0549-09	TCGA-13-1499-10A-01W-0549-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-04-1336-01A-01W-0488-09	TCGA-04-1336-11A-01W-0489-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518264	7518264	p.R248W	c.742C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-0982-01A-01W-0488-09	TCGA-24-0982-10C-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518264	7518264	p.R248W	c.742C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-0966-01A-01W-0977-09	TCGA-24-0966-10A-01W-0421-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518272	7518272	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245V	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518272	7518272	p.G245D	c.734G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0893-01B-01W-0494-09	TCGA-13-0893-10A-01W-0494-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518272	7518272	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245D	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518272	7518272	p.G245D	c.734G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	A	A	rs28934573	Unknown	TCGA-04-1349-01A-01W-0494-09	TCGA-04-1349-11A-01W-0494-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518284	7518284	p.S241F	c.722C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518290	7518290	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1464-01A-01W-0549-09	TCGA-24-1464-10A-01W-0549-09	T	T	T	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518290	7518290	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.716	p.N239S	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518290	7518290	p.N239S	c.716A>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7518295	7518295	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-1412-01A-01W-0494-09	TCGA-13-1412-10A-01W-0495-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518295	7518295	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.711	p.M237I	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518295	7518295	p.M237I	c.711G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518299	7518299	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-24-1616-01A-01W-0553-09	TCGA-24-1616-10A-01W-0553-09	T	T	C	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518299	7518299	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.707	p.Y236C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518299	7518299	p.Y236C	c.707A>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7518305	7518305	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-04-1361-01A-01W-0494-09	TCGA-04-1361-11A-01W-0494-09	T	T	T	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518305	7518305	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.701	p.Y234C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518305	7518305	p.Y234C	c.701A>G	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518305	7518305	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1425-01A-02W-0553-09	TCGA-24-1425-10A-01W-0553-09	T	T	T	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518305	7518305	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.701	p.Y234C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518305	7518305	p.Y234C	c.701A>G	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518324	7518325	+	Frame_Shift_Ins	INS	-	-	A	novel	Unknown	TCGA-24-1418-01A-01W-0549-09	TCGA-24-1418-10A-01W-0549-09	-	-	-	A	-	-	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518324	7518325	-	A	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.682_681	p.D227fs	0.998:0.801	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518324	7518324	p.D228Y	c.682G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7518334	7518334	+	Splice_Site	SNP	C	T	T	novel	Unknown	TCGA-04-1362-01A-01W-0494-09	TCGA-04-1362-10A-01W-0494-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518334	7518334	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.673-1	e6-1	0.99	-	-	-	no_errors	TP53	17	7518334	7518334	p.?	c.673-1G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7518928	7518928	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-24-1435-01A-01W-0549-09	TCGA-24-1435-10A-01W-0549-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518928	7518928	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.646	p.V216M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518928	7518928	p.V216M	c.646G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518929	7518929	+	Missense_Mutation	SNP	A	T	T	novel	Unknown	TCGA-04-1347-01A-01W-0488-09	TCGA-04-1347-11A-01W-0489-09	A	A	T	T	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518929	7518929	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.645	p.S215R	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518929	7518929	p.S215R	c.645T>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7518937	7518937	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0887-01A-01W-0421-09	TCGA-13-0887-10A-01W-0421-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518937	7518937	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.637	p.R213*	0.38	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518937	7518937	p.R213*	c.637C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518945	7518949	+	Frame_Shift_Del	DEL	TTTCT	TTTCT	-	novel	Unknown	TCGA-04-1343-01A-01W-0488-09	TCGA-04-1343-10A-01W-0489-09	TTTCT	TTTCT	TTTCT	-	TTTCT	TTTCT	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518945	7518949	TTTCT	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.629_625	p.R209fs	0.000:0.000:0.000:0.000:0.003	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518902,7519014])"	no_errors	TP53	17	7518945	7518945	p.N210S	c.629A>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7518960	7518960	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-13-0903-01A-01W-0421-09	TCGA-13-0903-10A-01W-0421-09	T	T	C	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518960	7518960	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.614	p.Y205C	0.97	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518960	7518960	p.Y205C	c.614A>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7518960	7518960	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-25-1322-01A-01W-0494-09	TCGA-25-1322-10A-01W-0494-09	T	T	T	C	T	T	Verified	Valid	Somatic	Phase_III	PCR	454_PCR_WGA		dbGAP	ABI 3730xl	17	7518960	7518960	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.614	p.Y205C	0.97	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518960	7518960	p.Y205C	c.614A>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7518982	7518982	+	Nonsense_Mutation	SNP	C	A	A	novel	Unknown	TCGA-24-1413-01A-01W-0494-09	TCGA-24-1413-10A-01W-0495-09	C	C	A	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518982	7518982	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.592	p.E198*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518982	7518982	p.E198*	c.592G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7518988	7518988	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-1405-01A-01W-0494-09	TCGA-13-1405-10A-01W-0495-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518988	7518988	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.586	p.R196*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518988	7518988	p.R196*	c.586C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-1104-01A-01W-0488-09	TCGA-24-1104-10A-01W-0488-09	A	A	A	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518990	7518990	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195T	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-1563-01A-01W-0553-09	TCGA-24-1563-10A-01W-0553-09	A	A	A	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518990	7518990	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195T	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	G	G	novel	Unknown	TCGA-24-1424-01A-01W-0549-09	TCGA-24-1424-10A-01W-0549-09	A	A	G	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518990	7518990	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195T	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	G	G	novel	Unknown	TCGA-24-1469-01A-01W-0553-09	TCGA-24-1469-10A-01W-0553-09	A	A	G	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518990	7518990	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195T	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	T	T	novel	Unknown	TCGA-24-1428-01A-01W-0549-09	TCGA-24-1428-10A-01W-0549-09	A	A	T	T	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518990	7518990	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518996	7518996	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-09-0369-01A-01W-0372-09	TCGA-09-0369-10C-01W-0372-09	T	T	C	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518996	7518996	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.578	p.H193R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518996	7518996	p.H193R	c.578A>G	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7518997	7518997	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0894-01B-01W-0494-09	TCGA-13-0894-10A-01W-0494-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518997	7518997	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.577	p.H193Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518997	7518997	p.H193Y	c.577C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7519015	7519015	+	Splice_Site	SNP	C	G	G	novel	Unknown	TCGA-10-0935-01A-03W-0421-09	TCGA-10-0935-11A-01W-0421-09	C	C	G	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519015	7519015	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.560-1	e5-1	0.38	-	-	-	no_errors	TP53	17	7519015	7519015	p.?	c.560-1G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7519113	7519113	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-04-1332-01A-01W-0488-09	TCGA-04-1332-10A-01W-0489-09	C	C	C	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519113	7519113	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.542	p.R181P	0.97	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519113	7519113	p.R181L	c.542G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7519119	7519119	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-04-1346-01A-01W-0488-09	TCGA-04-1346-11A-01W-0489-09	T	T	T	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519119	7519119	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.536	p.H179R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519119	7519119	p.H179R	c.536A>G	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7519125	7519125	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-1481-01A-01W-0549-09	TCGA-13-1481-10A-01W-0549-09	G	G	G	C	G	G	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519125	7519125	G	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.530	p.P177R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519125	7519125	p.P177L	c.530C>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-1404-01A-01W-0494-09	TCGA-13-1404-10A-01W-0495-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519128	7519128	p.C176Y	c.527G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-23-1123-01A-01W-0488-09	TCGA-23-1123-10A-01W-0488-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519128	7519128	p.C176Y	c.527G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7519156	7519157	+	Frame_Shift_Ins	INS	-	-	T	novel	Unknown	TCGA-24-0980-01A-01W-0421-09	TCGA-24-0980-10A-01W-0421-09	-	-	-	T	-	-	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519156	7519157	-	T	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.499_498	p.Q166fs	0.998:0.836	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519156	7519154	p.Q167del	c.499_501delCAG	Unknown
TP53	7157	genome.wustl.edu	36	17	7519165	7519165	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-23-1022-01A-02W-0488-09	TCGA-23-1022-10A-01W-0488-09	T	T	C	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519165	7519165	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.490	p.K164E	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519165	7519165	p.K164*	c.490A>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7519179	7519179	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-23-1021-01B-01W-0488-09	TCGA-23-1021-10A-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519179	7519179	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.476	p.A159V	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519179	7519179	p.A159V	c.476C>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	A	A	novel	Unknown	TCGA-13-0724-01A-01W-0372-09	TCGA-13-0724-10B-01W-0372-09	C	C	A	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519186	7519186	p.V157F	c.469G>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7519188	7519188	+	Missense_Mutation	SNP	C	G	G	novel	Unknown	TCGA-23-1124-01A-01W-0488-09	TCGA-23-1124-10A-01W-0488-09	C	C	G	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519188	7519188	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.467	p.R156P	0.01	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519188	7519188	p.R156H	c.467G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7519195	7519225	+	Frame_Shift_Del	DEL	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	-	novel	Unknown	TCGA-23-1117-01A-02W-0488-09	TCGA-23-1117-10A-01W-0488-09	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	-	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519195	7519225	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.460_430	p.Q144fs	0.496:0.001:0.001:0.001:0.001:0.996:0.998:0.906:0.998:0.997:0.001:0.001:0.001:0.000:0.000:0.000:0.000:0.000:0.000:0.014:0.987:0.994:0.947:0.886:0.843:0.860:0.979:0.970:0.987:0.998:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	17	7519195	7519187	p.G154_R156delGTR	c.460_468delGGCACCCGC	Unknown
TP53	7157	genome.wustl.edu	36	17	7519204	7519204	+	Missense_Mutation	SNP	G	G	A	rs28934874	Unknown	TCGA-23-1118-01A-01W-0488-09	TCGA-23-1118-10A-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519204	7519204	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.451	p.P151S	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519204	7519204	p.P151S	c.451C>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7519217	7519217	+	Nonsense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0885-01A-02W-0421-09	TCGA-13-0885-10A-01W-0421-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519217	7519217	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.438	p.W146*	0.95	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519217	7519217	p.W146*	c.438G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7519230	7519236	+	Frame_Shift_Del	DEL	GGGCAGG	GGGCAGG	-	novel	Unknown	TCGA-13-1507-01A-01W-0549-09	TCGA-13-1507-10A-01W-0550-09	GGGCAGG	GGGCAGG	GGGCAGG	-	GGGCAGG	GGGCAGG	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519230	7519236	GGGCAGG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.425_419	p.T140fs	0.999:1.000:1.000:1.000:1.000:0.996:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	17	7519230	7519230	p.P142H	c.425C>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7519251	7519251	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0795-01A-01W-0372-09	TCGA-13-0795-10A-01W-0372-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519251	7519251	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.404	p.C135Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519251	7519251	p.C135Y	c.404G>A	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7519259	7519259	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-0366-01A-01W-0372-09	TCGA-09-0366-10B-01W-0372-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519259	7519259	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.396	p.K132N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519259	7519259	p.K132N	c.396G>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7519260	7519260	+	Missense_Mutation	SNP	T	A	A	novel	Unknown	TCGA-13-0800-01A-01W-0372-09	TCGA-13-0800-10A-01W-0372-09	T	T	A	A	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519260	7519260	T	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.395	p.K132M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519260	7519260	p.K132R	c.395A>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7519280	7519280	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-13-0890-01A-01W-0421-09	TCGA-13-0890-10A-01W-0421-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519280	7519280	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.376-1	e4-1	1	-	-	-	no_errors	TP53	17	7519280	7519280	p.?	c.376-1G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7520036	7520036	+	Splice_Site	SNP	C	A	A	novel	Unknown	TCGA-13-1403-01A-01W-0494-09	TCGA-13-1403-10A-01W-0495-09	C	C	A	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7520036	7520036	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.375+1	e3+1	1	-	-	-	no_errors	TP53	17	7520036	7520036	p.?	c.375+1G>A	Unknown
TP53	7157	genome.wustl.edu	36	17	7520037	7520037	+	Silent	SNP	C	C	A	rs55863639	Unknown	TCGA-13-0755-01A-01W-0372-09	TCGA-13-0755-10A-01W-0372-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7520037	7520037	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	silent	c.375	p.T125	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520037	7520037	p.T125T	c.375G>T	
TP53	7157	genome.wustl.edu	36	17	7520114	7520114	+	Nonsense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-13-0920-01A-01W-0421-09	TCGA-13-0920-10A-01W-0421-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7520114	7520114	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.298	p.Q100*	0.6	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520114	7520114	p.Q100*	c.298C>T	Unknown
TP53	7157	genome.wustl.edu	36	17	7520317	7520317	+	Splice_Site	SNP	T	T	A	novel	Unknown	TCGA-24-1562-01A-01W-0553-09	TCGA-24-1562-10A-01W-0553-09	T	T	T	A	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7520317	7520317	T	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.97-2	e3-2	0.19	-	-	-	no_errors	TP53	17	7520317	7520317	p.?	c.97-2A>T	Unknown
FAM171B	165215	genome.wustl.edu	36	2	187335599	187335599	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-23-1123-01A-01W-0488-09	TCGA-23-1123-10A-01W-0488-09	A	A	A	C	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	2	187335599	187335599	A	C	SNP	FAM171B	NM_177454	human	genbank	54_36p	1	validated	missense	c.2285	p.H762P	1	HMMPfam_UPF0560	HMMPfam_UPF0560	-	no_errors	FAM171B	2	187335598	187335598	p.H762D	c.2284C>G	Confirmed
RB1	5925	hgsc.bcm.edu	36	13	47835024	47835024	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-09-1665-01B-01W-0615-10	TCGA-09-1665-11B-01W-0616-10	C	C	C	C	C	C	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	13	47835024	47835024	C	T	SNP	RB1	NM_000321	human	genbank	54_36p	1	reviewed	missense	c.791	p.A264V	1	NULL	"HMMPfam_RB_A,superfamily_Cyclin-like,HMMPfam_RB_B,HMMSmart_SM00385,HMMPfam_Rb_C"	-	no_errors	RB1	13	47835026	47835026	p.K265*	c.793A>T	Unknown
RB1	5925	hgsc.bcm.edu	36	13	47849054	47849054	+	Splice_Site	SNP	G	G	C	novel	Unknown	TCGA-25-1635-01A-01W-0615-10	TCGA-25-1635-10A-01W-0616-10	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	13	47849054	47849054	G	C	SNP	RB1	NM_000321	human	genbank	54_36p	1	reviewed	splice_site	c.1216-1	e13-1	1	-	-	-	no_errors	RB1	13	47849054	47849054	p.?	c.1216-1G>A	Unknown
RB1	5925	hgsc.bcm.edu	36	13	47928388	47928388	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-04-1350-01A-01W-0490-10	TCGA-04-1350-11A-01W-0490-10	G	G	G	G	G	G	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	13	47928388	47928388	G	C	SNP	RB1	NM_000321	human	genbank	54_36p	1	reviewed	missense	c.1862	p.R621P	1	NULL	"HMMPfam_RB_B,HMMPfam_RB_A,HMMSmart_SM00385,superfamily_Cyclin-like,HMMPfam_Rb_C"	-	no_errors	RB1	13	47928387	47928387	p.R621S	c.1861C>A	Unknown
BRCA1	672	hgsc.bcm.edu	36	17	38451310	38451310	+	Nonsense_Mutation	SNP	G	G	A	rs41293465	Unknown	TCGA-13-0730-01A-01W-0370-10	TCGA-13-0730-10B-01W-0370-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	38451310	38451310	G	A	SNP	BRCA1	NM_007294	human	genbank	54_36p	-1	reviewed	nonsense	c.5503	p.R1835*	0.99	"HMMPfam_BRCT,HMMSmart_SM00292,superfamily_BRCT domain"	"superfamily_RING/U-box,HMMSmart_SM00184,HMMPfam_zf-C3HC4,PatternScan_ZF_RING_1,HMMPfam_BRCT,HMMSmart_SM00292,superfamily_BRCT domain"	-	no_errors	BRCA1				p.R1835*	c.?	Confirmed
TP53	7157	hgsc.bcm.edu	36	17	7514743	7514743	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-36-1571-01A-01W-0615-10	TCGA-36-1571-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7514743	7514743	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.1009	p.R337C	0.47	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"HMMPfam_P53_TAD,HMMPfam_P53,superfamily_p53-like transcription factors,PatternScan_P53,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	-	no_errors	TP53	17	7514743	7514743	p.R337C	c.1009C>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7517577	7517577	+	Splice_Site	SNP	C	C	A	rs11575997	Unknown	TCGA-10-0938-01A-02W-0419-10	TCGA-10-0938-11A-01W-0419-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517577	7517577	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.993+1	e8+1	0.99	-	-	-	no_errors	TP53	17	7517577	7517577	p.?	c.993+1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7517577	7517577	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-09-1669-01A-01W-0615-10	TCGA-09-1669-10A-01W-0616-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517577	7517577	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.993+1	e8+1	0.99	-	-	-	no_errors	TP53	17	7517577	7517577	p.?	c.993+1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7517652	7517652	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-24-1556-01A-01W-0615-10	TCGA-24-1556-10A-01W-0615-10	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517652	7517652	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.920-1	e8-1	0.97	-	-	-	no_errors	TP53	17	7517652	7517652	p.?	c.920-1G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517652	7517652	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-24-1604-01A-01W-0552-10	TCGA-24-1604-10A-01W-0552-10	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517652	7517652	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.920-1	e8-1	0.97	-	-	-	no_errors	TP53	17	7517652	7517652	p.?	c.920-1G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517783	7517783	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-1659-01B-01W-0615-10	TCGA-09-1659-10A-01W-0616-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517783	7517783	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.880	p.E294*	0.01	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517783	7517783	p.E294*	c.880G>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7517818	7517818	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-04-1525-01A-01W-0615-10	TCGA-04-1525-10A-01W-0615-10	C	C	C	C	C	C	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517818	7517818	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.845	p.R282P	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517818	7517818	p.R282Q	c.845G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7517818	7517819	+	Frame_Shift_Ins	INS	-	-	G	novel	Unknown	TCGA-04-1525-01A-01W-0615-10	TCGA-04-1525-10A-01W-0615-10	-	-	-	G	-	-	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517818	7517819	-	G	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.845_844	p.R282fs	0.996:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517818	7517818	p.R282Q	c.845G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-10-0937-01A-02W-0419-10	TCGA-10-0937-11A-01W-0419-10	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517819	7517819	p.R282W	c.844C>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-24-1567-01A-01W-0615-10	TCGA-24-1567-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517819	7517819	p.R282W	c.844C>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-25-1623-01A-01W-0615-10	TCGA-25-1623-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517819	7517819	p.R282W	c.844C>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517821	7517821	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-23-1023-01A-03W-0484-10	TCGA-23-1023-10A-01W-0484-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517821	7517821	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.842	p.D281G	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517821	7517821	p.D281A	c.842A>C	Confirmed
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-04-1530-01A-02W-0552-10	TCGA-04-1530-10A-01W-0552-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-13-0761-01A-01W-0370-10	TCGA-13-0761-10A-01W-0370-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-13-0900-01B-01W-0490-10	TCGA-13-0900-10A-01W-0490-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-24-1558-01A-01W-0615-10	TCGA-24-1558-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-36-1575-01A-01W-0615-10	TCGA-36-1575-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-36-1578-01A-01W-0615-10	TCGA-36-1578-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0889-01A-01W-0419-10	TCGA-13-0889-10A-01W-0419-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517846	7517846	p.R273C	c.817C>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-36-1580-01A-01W-0615-10	TCGA-36-1580-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517846	7517846	p.R273C	c.817C>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518231	7518231	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-1665-01B-01W-0615-10	TCGA-09-1665-11B-01W-0616-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518231	7518231	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.775	p.D259Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518231	7518231	p.D259Y	c.775G>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518231	7518231	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1635-01A-01W-0615-10	TCGA-25-1635-10A-01W-0616-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518231	7518231	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.775	p.D259Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518231	7518231	p.D259Y	c.775G>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518257	7518257	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-23-1028-01A-01W-0484-10	TCGA-23-1028-10B-01W-0484-10	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518257	7518257	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.749	p.P250L	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518257	7518257	p.P250L	c.749C>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	T	T	rs11540652	byHapMap	TCGA-04-1364-01A-01W-0490-10	TCGA-04-1364-10A-01W-0490-10	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518263	7518264	+	Frame_Shift_Ins	INS	-	-	G	novel	Unknown	TCGA-36-1570-01A-01W-0615-10	TCGA-36-1570-10A-01W-0615-10	-	-	-	G	-	-	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518263	7518264	-	G	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.743_742	p.R248fs	1.000:1.000	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518262	p.R248Q	c.743_744GG>AA	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	C	C	novel	Unknown	TCGA-25-1632-01A-01W-0615-10	TCGA-25-1632-10A-01W-0615-10	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518264	7518264	G	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248G	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518264	7518264	p.R248W	c.742C>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1626-01A-01W-0615-10	TCGA-25-1626-10A-01W-0615-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518272	7518272	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245V	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518272	7518272	p.G245D	c.734G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1317-01A-01W-0490-10	TCGA-25-1317-10A-01W-0490-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518273	7518273	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245C	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518273	7518273	p.G245S	c.733G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	T	rs28934575	Unknown	TCGA-04-1338-01A-01W-0484-10	TCGA-04-1338-11A-01W-0485-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518273	7518273	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245S	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518273	7518273	p.G245S	c.733G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	T	rs28934575	Unknown	TCGA-36-1568-01A-01W-0615-10	TCGA-36-1568-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7518273	7518273	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245S	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518273	7518273	p.G245S	c.733G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518276	7518276	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1560-01A-01W-0615-10	TCGA-24-1560-10A-01W-0615-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518276	7518276	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.730	p.G244C	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518276	7518276	p.G244S	c.730G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-24-1545-01A-01W-0615-10	TCGA-24-1545-10A-01W-0615-10	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518284	7518284	G	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241Y	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518284	7518284	p.S241F	c.722C>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518291	7518292	+	Frame_Shift_Ins	INS	-	-	A	novel	Unknown	TCGA-13-0792-01A-01W-0370-10	TCGA-13-0792-10A-01W-0370-10	-	-	-	A	-	-	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518291	7518292	-	A	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.715_714	p.N238fs	1.000:0.999	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518291	7518291	p.N239D	c.715A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518299	7518299	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-57-1582-01A-01W-0615-10	TCGA-57-1582-11A-01W-0615-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518299	7518299	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.707	p.Y236C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518299	7518299	p.Y236C	c.707A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518319	7518320	+	Frame_Shift_Del	DEL	AC	AC	-	novel	Unknown	TCGA-57-1583-01A-01W-0615-10	TCGA-57-1583-11A-01W-0615-10	AC	AC	AC	-	AC	AC	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518319	7518320	AC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.687_686	p.C229fs	0.995:0.995	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	17	7518319	7518319	p.C229*	c.687T>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518901	7518901	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-36-1577-01A-01W-0615-10	TCGA-36-1577-10A-01W-0615-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518901	7518901	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.672+1	e5+1	1	-	-	-	no_errors	TP53	17	7518901	7518901	p.?	c.672+1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1548-01A-01W-0615-10	TCGA-24-1548-10A-01W-0615-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1553-01A-01W-0552-10	TCGA-24-1553-10A-01W-0552-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-25-1627-01A-01W-0615-10	TCGA-25-1627-10A-01W-0615-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518927	7518927	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-04-1364-01A-01W-0490-10	TCGA-04-1364-10A-01W-0490-10	A	A	A	A	A	A	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518927	7518927	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.647	p.V216G	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518927	7518927	p.V216E	c.647T>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7518928	7518928	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-25-1625-01A-01W-0615-10	TCGA-25-1625-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	17	7518928	7518928	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.646	p.V216M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518928	7518928	p.V216M	c.646G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518996	7518996	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-0762-01A-01W-0370-10	TCGA-13-0762-10A-01W-0370-10	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518996	7518996	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.578	p.H193R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518996	7518996	p.H193R	c.578A>G	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518996	7518996	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-0968-01A-01W-0484-10	TCGA-24-0968-10C-01W-0484-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518996	7518996	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.578	p.H193R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518996	7518996	p.H193R	c.578A>G	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519015	7519015	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-09-1661-01B-01W-0615-10	TCGA-09-1661-10A-01W-0616-10	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7519015	7519015	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.560-1	e5-1	0.38	-	-	-	no_errors	TP53	17	7519015	7519015	p.?	c.560-1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519118	7519118	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-24-1555-01A-01W-0552-10	TCGA-24-1555-10A-01W-0552-10	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519118	7519118	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.537	p.H179Q	0.89	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519118	7519118	p.H179Q	c.537T>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519119	7519119	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-04-1350-01A-01W-0490-10	TCGA-04-1350-11A-01W-0490-10	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519119	7519119	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.536	p.H179R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519119	7519119	p.H179R	c.536A>G	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519123	7519123	+	Frame_Shift_Del	DEL	G	G	-	novel	Unknown	TCGA-13-0730-01A-01W-0370-10	TCGA-13-0730-10B-01W-0370-10	G	G	G	-	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519123	7519123	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.532	p.H178fs	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	17	7519123	7519123	p.H178fs*69	c.532delC	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519123	7519123	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-13-0730-01A-01W-0370-10	TCGA-13-0730-10B-01W-0370-10	G	G	G	G	G	G	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519123	7519123	G	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.532	p.H178N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519123	7519123	p.H178N	c.532C>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	A	A	novel	Unknown	TCGA-24-1544-01A-01W-0615-10	TCGA-24-1544-10A-01W-0615-10	C	C	C	C	C	C	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519128	7519128	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176F	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519128	7519128	p.C176Y	c.527G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-09-1662-01A-01W-0615-10	TCGA-09-1662-10A-01W-0616-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519128	7519128	p.C176Y	c.527G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-57-1584-01A-01W-0615-10	TCGA-57-1584-11A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519128	7519128	p.C176Y	c.527G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-25-1318-01A-01W-0490-10	TCGA-25-1318-10A-01W-0490-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-25-1633-01A-01W-0615-10	TCGA-25-1633-10A-01W-0616-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519138	7519138	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1630-01A-01W-0615-10	TCGA-25-1630-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	17	7519138	7519138	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.517	p.V173L	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519138	7519138	p.V173L	c.517G>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519179	7519179	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0720-01A-01W-0370-10	TCGA-13-0720-10B-01W-0370-10	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519179	7519179	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.476	p.A159V	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519179	7519179	p.A159V	c.476C>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0919-01A-01W-0419-10	TCGA-13-0919-10A-01W-0419-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519186	7519186	p.V157F	c.469G>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1105-01A-01W-0484-10	TCGA-24-1105-10A-01W-0484-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519186	7519186	p.V157F	c.469G>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1614-01A-01W-0552-10	TCGA-24-1614-10A-01W-0552-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519186	7519186	p.V157F	c.469G>T	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7519192	7519192	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-25-1630-01A-01W-0615-10	TCGA-25-1630-10A-01W-0615-10	T	T	T	T	T	T	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519192	7519192	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.463	p.T155A	0	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519192	7519192	p.T155A	c.463A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519252	7519252	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-04-1337-01A-01W-0484-10	TCGA-04-1337-11A-01W-0485-10	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519252	7519252	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.403	p.C135R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519252	7519252	p.C135R	c.403T>C	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519255	7519255	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-13-0906-01A-01W-0419-10	TCGA-13-0906-10A-01W-0419-10	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519255	7519255	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.400	p.F134V	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519255	7519255	p.F134V	c.400T>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519260	7519260	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-23-1026-01B-01W-0484-10	TCGA-23-1026-10A-01W-0484-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7519260	7519260	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.395	p.K132R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519260	7519260	p.K132R	c.395A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519275	7519275	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0714-01A-01W-0370-10	TCGA-13-0714-10B-01W-0370-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519275	7519275	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.380	p.S127F	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519275	7519275	p.S127F	c.380C>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519280	7519280	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-09-1666-01A-01W-0615-10	TCGA-09-1666-10A-01W-0616-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7519280	7519280	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.376-1	e4-1	1	-	-	-	no_errors	TP53	17	7519280	7519280	p.?	c.376-1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519280	7519280	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-04-1365-01A-01W-0490-10	TCGA-04-1365-10A-01W-0490-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519280	7519280	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.376-1	e4-1	1	-	-	-	no_errors	TP53	17	7519280	7519280	p.?	c.376-1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519280	7519280	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-25-1324-01A-01W-0490-10	TCGA-25-1324-10A-01W-0490-10	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519280	7519280	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.376-1	e4-1	1	-	-	-	no_errors	TP53	17	7519280	7519280	p.?	c.376-1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519281	7519281	+	Splice_Site	SNP	T	C	C	novel	Unknown	TCGA-04-1514-01A-01W-0552-10	TCGA-04-1514-10A-01W-0552-10	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519281	7519281	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.376-2	e4-2	1	-	-	-	no_errors	TP53	17	7519281	7519281	p.?	c.376-2A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519281	7519281	+	Splice_Site	SNP	T	T	C	novel	Unknown	TCGA-24-1557-01A-01W-0615-10	TCGA-24-1557-10A-01W-0615-10	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7519281	7519281	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.376-2	e4-2	1	-	-	-	no_errors	TP53	17	7519281	7519281	p.?	c.376-2A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520036	7520036	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-25-1631-01A-01W-0615-10	TCGA-25-1631-10A-01W-0615-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7520036	7520036	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.375+1	e3+1	1	-	-	-	no_errors	TP53	17	7520036	7520036	p.?	c.375+1G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520042	7520042	+	Frame_Shift_Del	DEL	A	A	-	novel	Unknown	TCGA-13-0793-01A-01W-0370-10	TCGA-13-0793-10A-01W-0370-10	A	A	A	-	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	SOLID			SOLID	17	7520042	7520042	A	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.370	p.C124fs	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520042	7520041	p.C124fs*25	c.370_371insN	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520086	7520086	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-13-1407-01A-01W-0490-10	TCGA-13-1407-10A-01W-0491-10	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7520086	7520086	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.326	p.F109C	0.36	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520086	7520086	p.F109S	c.326T>C	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520087	7520088	+	Frame_Shift_Ins	INS	-	-	ACCGT	novel	Unknown	TCGA-23-1024-01A-02W-0484-10	TCGA-23-1024-10A-01W-0484-10	-	-	-	ACCGT	-	-	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7520087	7520088	-	ACCGT	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.325_324	p.F108fs	0.330:0.183	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520087	7520082	p.F109_R110delFR	c.325_330delTTCCGT	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520099	7520099	+	Missense_Mutation	SNP	C	T	T	novel	Unknown	TCGA-10-0928-01A-02W-0419-10	TCGA-10-0928-11A-01W-0419-10	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7520099	7520099	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.313	p.G105S	0.73	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520099	7520099	p.G105C	c.313G>T	Confirmed
TP53	7157	hgsc.bcm.edu	36	17	7520219	7520219	+	Nonsense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-04-1517-01A-01W-0615-10	TCGA-04-1517-11A-01W-0615-10	T	T	A	A	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7520219	7520219	T	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.193	p.R65*	0	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520219	7520219	p.R65*	c.193A>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520254	7520254	+	Nonsense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-36-1569-01A-01W-0615-10	TCGA-36-1569-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7520254	7520254	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.158	p.W53*	0.01	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520254	7520254	p.W53*	c.158G>A	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520261	7520261	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1628-01A-01W-0615-10	TCGA-25-1628-10A-01W-0615-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7520261	7520261	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.151	p.E51*	0	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520261	7520261	p.E51*	c.151G>T	Unknown
RB1	5925	broad.mit.edu	36	13	47839649	47839649	+	Nonsense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-23-2079-01A-01W-0722-08	TCGA-23-2079-10A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	13	47839649	47839649	C	T	SNP	RB1	NM_000321	human	genbank	54_36p	1	reviewed	nonsense	c.958	p.R320*	1	NULL	"HMMPfam_RB_A,superfamily_Cyclin-like,HMMPfam_RB_B,HMMSmart_SM00385,HMMPfam_Rb_C"	-	no_errors	RB1	13	47839649	47839649	p.R320*	c.958C>T	Confirmed
TP53	7157	broad.mit.edu	36	17	7514709	7514710	+	Frame_Shift_Ins	INS	-	-	AGGCCTT	novel	Unknown	TCGA-13-0751-01A-01D	TCGA-13-0751-10A-01D	-	-	AGGCCTT	AGGCCTT	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7514709	7514710	-	AGGCCTT	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.1043_1042	p.L348fs	0.992:0.323	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"HMMPfam_P53_TAD,HMMPfam_P53,superfamily_p53-like transcription factors,PatternScan_P53,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	-	no_errors	TP53	17	7514709	7514709	p.L348*	c.1043T>A	Unknown
TP53	7157	broad.mit.edu	36	17	7514720	7514720	+	Frame_Shift_Del	DEL	C	C	-	novel	Unknown	TCGA-24-1434-01A-01W	TCGA-24-1434-10A-01W	C	C	-	-	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7514720	7514720	C	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.1032	p.N345fs	0.72	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7514652,7514758])"	no_errors	TP53	17	7514725	7514725	p.E343*	c.1027G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7514728	7514728	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-61-2097-01A-02W-0722-08	TCGA-61-2097-11A-01W-0723-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7514728	7514728	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.1024	p.R342*	0.4	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"HMMPfam_P53_TAD,HMMPfam_P53,superfamily_p53-like transcription factors,PatternScan_P53,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	-	no_errors	TP53	17	7514728	7514728	p.R342*	c.1024C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517577	7517577	+	Splice_Site	SNP	C	C	T	rs11575997	Unknown	TCGA-23-2072-01A-01W-0722-08	TCGA-23-2072-10A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517577	7517577	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.993+1	e8+1	0.99	-	-	-	no_errors	TP53	17	7517577	7517577	p.?	c.993+1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7517577	7517577	+	Splice_Site	SNP	C	C	A	rs11575997	Unknown	TCGA-59-2355-01A-01W-0799-08	TCGA-59-2355-10A-01W-0800-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517577	7517577	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.993+1	e8+1	0.99	-	-	-	no_errors	TP53	17	7517577	7517577	p.?	c.993+1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7517610	7517610	+	Nonsense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-24-2271-01A-01W-0799-08	TCGA-24-2271-10A-01W-0799-08	T	T	A	A	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517610	7517610	T	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.961	p.K321*	0.98	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517610	7517610	p.K321*	c.961A>T	Unknown
TP53	7157	broad.mit.edu	36	17	7517622	7517622	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0899-01A-01W	TCGA-13-0899-10A-01D	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture,Sequenom"			Illumina GAIIx	17	7517622	7517622	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.949	p.Q317*	0.55	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517622	7517622	p.Q317*	c.949C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7517625	7517626	+	Frame_Shift_Ins	INS	-	A	A	novel	Unknown	TCGA-24-1603-01A-01W	TCGA-24-1603-10A-01W	-	-	A	A	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7517625	7517626	-	A	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.946_945	p.P315fs	0.962:0.964	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517625	7517624	p.Q317fs*19	c.946_947delCC	Unknown
TP53	7157	broad.mit.edu	36	17	7517744	7517745	+	Frame_Shift_Del	DEL	CT	CT	-	novel	Unknown	TCGA-61-2109-01A-01W-0722-08	TCGA-61-2109-11A-01W-0723-08	CT	CT	CT	-	CT	CT	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7517744	7517745	CT	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.919_918	p.A307fs	0.998:0.997	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7517744,7517880])"	no_errors	TP53	17	7517744	7517640	p.A307fs*34	c.919_931del13	Unknown
TP53	7157	broad.mit.edu	36	17	7517747	7517747	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-04-1331-01A-01W	TCGA-04-1331-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517747	7517747	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.916	p.R306*	1	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517747	7517747	p.R306*	c.916C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517807	7517807	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-25-1326-01A-01W	TCGA-25-1326-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Broad454,Capture"			Illumina GAIIx	17	7517807	7517807	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.856	p.E286K	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517807	7517807	p.E286K	c.856G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7517813	7517813	+	Frame_Shift_Del	DEL	T	-	T	novel	Unknown	TCGA-24-2267-01A-01W-0799-08	TCGA-24-2267-11A-01W-0799-08	T	T	-	-	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7517813	7517813	T	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.850	p.T284fs	0.04	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7517744,7517880])"	no_errors	TP53	17	7517813	7517813	p.T284P	c.850A>C	Unknown
TP53	7157	broad.mit.edu	36	17	7517827	7517827	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0904-01A-02W	TCGA-13-0904-10A-01D	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517827	7517827	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.836	p.G279E	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517827	7517827	p.G279E	c.836G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7517830	7517830	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-13-0913-01A-01W	TCGA-13-0913-10A-01D	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517830	7517830	G	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.833	p.P278R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517830	7517830	p.P278R	c.833C>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517830	7517830	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-24-1552-01A-01W	TCGA-24-1552-10A-01W	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Broad454,Capture"			Illumina GAIIx	17	7517830	7517830	G	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.833	p.P278H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517830	7517830	p.P278R	c.833C>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517842	7517842	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-24-2290-01A-01W-0799-08	TCGA-24-2290-10A-01W-0799-08	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517842	7517842	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.821	p.V274G	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517842	7517842	p.V274A	c.821T>C	Unknown
TP53	7157	broad.mit.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	A	rs28934576	Unknown	TCGA-13-1512-01A-01W	TCGA-13-1512-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517845	7517845	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273L	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-10-0934-01A-02W	TCGA-10-0934-11A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	G	rs28934576	Unknown	TCGA-13-0905-01B-01W	TCGA-13-0905-10A-01W	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517845	7517845	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273P	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-2392-01A-01W-0799-08	TCGA-25-2392-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517846	7517846	p.R273C	c.817C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-59-2348-01A-01W-0799-08	TCGA-59-2348-11A-01W-0800-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517846	7517846	p.R273C	c.817C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-1321-01A-01W	TCGA-25-1321-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517846	7517846	p.R273C	c.817C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517849	7517849	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0886-01A-01W	TCGA-13-0886-10A-01D	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517849	7517849	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.814	p.V272M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517849	7517849	p.V272M	c.814G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517849	7517849	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-24-2024-01A-02W-0722-08	TCGA-24-2024-11A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517849	7517849	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.814	p.V272M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517849	7517849	p.V272M	c.814G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517852	7517852	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1471-01A-01W	TCGA-24-1471-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517852	7517852	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.811	p.E271*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517852	7517852	p.E271*	c.811G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7517866	7517866	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-61-2113-01A-01W-0722-08	TCGA-61-2113-11A-01W-0723-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517866	7517866	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.797	p.G266V	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517866	7517866	p.G266V	c.797G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7517866	7517866	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-59-2352-01A-01W-0799-08	TCGA-59-2352-10A-01W-0800-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517866	7517866	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.797	p.G266V	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517866	7517866	p.G266V	c.797G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7517867	7517867	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-61-2102-01A-01W-0722-08	TCGA-61-2102-11A-01W-0723-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517867	7517867	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.796	p.G266R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517867	7517867	p.G266R	c.796G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517871	7517881	+	Splice_Site	DEL	TAGATTACCAC	TAGATTACCAC	-	novel	Unknown	TCGA-23-1116-01A-01W	TCGA-23-1116-10A-01W	TAGATTACCAC	TAGATTACCAC	-	-	TAGATTACCAC	TAGATTACCAC	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7517871	7517881	TAGATTACCAC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site_del	c.792_783	p.G262fs	0.348:0.418:0.272:0.006:0.011:0.018:0.004:0.996:1.000:0.996	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7517744,7517880], intron[7517881,7518223])"	no_errors	TP53	17	7517871	7517870	p.L265fs*81	c.792_793insNN	Unknown
TP53	7157	broad.mit.edu	36	17	7517878	7517878	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-23-2081-01A-01W-0722-08	TCGA-23-2081-10A-01W-0722-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517878	7517878	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.785	p.G262V	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517878	7517878	p.G262V	c.785G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518223	7518223	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-13-1409-01A-01W	TCGA-13-1409-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7518223	7518223	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.782+1	e6+1	1	-	-	-	no_errors	TP53	17	7518223	7518223	p.?	c.782+1G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518236	7518236	+	Missense_Mutation	SNP	A	A	T	rs28934577	Unknown	TCGA-09-2050-01A-01W-0799-08	TCGA-09-2050-10A-01W-0799-08	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518236	7518236	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.770	p.L257Q	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518236	7518236	p.L257P	c.770T>C	Unknown
TP53	7157	broad.mit.edu	36	17	7518239	7518241	+	In_Frame_Del	DEL	GTG	-	GTG	novel	Unknown	TCGA-23-2078-01A-01W-0722-08	TCGA-23-2078-10A-01W-0722-08	GTG	GTG	-	-	GTG	GTG	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518239	7518241	GTG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.767_765	p.T256in_frame_del	1.000:1.000:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	17	7518239	7518239	p.T256I	c.767C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518239	7518247	+	In_Frame_Del	DEL	GTGATGATG	GTGATGATG	-	novel	Unknown	TCGA-23-1031-01A-01W	TCGA-23-1031-10A-01W	GTGATGATG	GTGATGATG	-	-	GTGATGATG	GTGATGATG	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518239	7518247	GTGATGATG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.767_759	p.IIT254in_frame_del	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	17	7518239	7518239	p.T256I	c.767C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518254	7518254	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-13-1504-01A-01W	TCGA-13-1504-10A-01W	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518254	7518254	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.752	p.I251S	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518254	7518254	p.I251T	c.752T>C	Unknown
TP53	7157	broad.mit.edu	36	17	7518257	7518257	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-2288-01A-01W-0799-08	TCGA-24-2288-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7518257	7518257	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.749	p.P250L	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518257	7518257	p.P250L	c.749C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518261	7518261	+	Missense_Mutation	SNP	T	T	C	rs67185453	Unknown	TCGA-24-1466-01A-01W	TCGA-24-1466-10A-01W	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518261	7518261	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.745	p.R249G	0.99	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518261	7518261	p.R249W	c.745A>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-24-0979-01A-01W	TCGA-24-0979-10B-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-24-1419-01A-01W	TCGA-24-1419-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-23-1032-01A-02W	TCGA-23-1032-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-13-1496-01A-01W	TCGA-13-1496-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-10-0934-01A-02W	TCGA-10-0934-11A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-57-1993-01A-01W-0699-08	TCGA-57-1993-11A-01W-0700-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-24-2260-01A-01W-0722-08	TCGA-24-2260-11A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518263	7518263	p.R248Q	c.743G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-2409-01A-01W-0799-08	TCGA-25-2409-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518264	7518264	p.R248W	c.742C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-1422-01A-01W	TCGA-24-1422-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518264	7518264	p.R248W	c.742C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-1551-01A-01W	TCGA-24-1551-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518264	7518264	p.R248W	c.742C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-30-1853-01A-02W-0699-08	TCGA-30-1853-10A-01W-0699-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518272	7518272	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245D	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518272	7518272	p.G245D	c.734G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	G	rs28934575	Unknown	TCGA-61-1736-01B-01W-0722-08	TCGA-61-1736-11A-01W-0722-08	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518273	7518273	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245R	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518273	7518273	p.G245S	c.733G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	T	rs28934575	Unknown	TCGA-09-2049-01D-01W-0799-08	TCGA-09-2049-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518273	7518273	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245S	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518273	7518273	p.G245S	c.733G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518275	7518275	+	Missense_Mutation	SNP	C	C	T	rs28934572	Unknown	TCGA-29-2427-01A-01W-0799-08	TCGA-29-2427-10A-01W-0800-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518275	7518275	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.731	p.G244D	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518275	7518275	p.G244D	c.731G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518276	7518276	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-61-2111-01A-01W-0722-08	TCGA-61-2111-11A-01W-0723-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518276	7518276	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.730	p.G244C	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518276	7518276	p.G244S	c.730G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	A	rs28934573	Unknown	TCGA-04-1367-01A-01W	TCGA-04-1367-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518284	7518284	p.S241F	c.722C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	A	rs28934573	Unknown	TCGA-24-2254-01A-01W-0722-08	TCGA-24-2254-10A-01W-0722-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518284	7518284	p.S241F	c.722C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	A	rs28934573	Unknown	TCGA-20-0991-01A-03D	TCGA-20-0991-10A-01D	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518284	7518284	p.S241F	c.722C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518288	7518296	+	In_Frame_Del	DEL	TGTTACACA	TGTTACACA	-	novel	Unknown	TCGA-61-2088-01A-01W-0722-08	TCGA-61-2088-11A-01W-0722-08	TGTTACACA	TGTTACACA	TGTTACACA	-	TGTTACACA	TGTTACACA	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518288	7518296	TGTTACACA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.718_710	p.MCN237in_frame_del	1.000:1.000:1.000:1.000:0.999:1.000:1.000:1.000:1.000	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	17	7518288	7518288	p.S240G	c.718A>G	Unknown
TP53	7157	broad.mit.edu	36	17	7518291	7518292	+	Frame_Shift_Ins	INS	-	A	-	novel	Unknown	TCGA-13-0883-01A-02W	TCGA-13-0883-10A-01D	-	-	A	A	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518291	7518292	-	A	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.715_714	p.N238fs	1.000:0.999	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518291	7518291	p.N239D	c.715A>G	Unknown
TP53	7157	broad.mit.edu	36	17	7518293	7518293	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-61-1995-01A-01W-0722-08	TCGA-61-1995-11A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518293	7518293	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.713	p.C238Y	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518293	7518293	p.C238Y	c.713G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518293	7518293	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-31-1959-01A-01W-0699-08	TCGA-31-1959-10A-01W-0700-08	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518293	7518293	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.713	p.C238F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518293	7518293	p.C238Y	c.713G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518296	7518296	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-13-1487-01A-01D	TCGA-13-1487-10A-01W	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518296	7518296	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.710	p.M237K	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518296	7518296	p.M237R	c.710T>G	Unknown
TP53	7157	broad.mit.edu	36	17	7518306	7518306	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-13-1484-01A-01W	TCGA-13-1484-10A-01W	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518306	7518306	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.700	p.Y234N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518306	7518306	p.Y234N	c.700T>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518311	7518311	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-24-2019-01A-02W-0722-08	TCGA-24-2019-10A-01W-0722-08	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518311	7518311	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.695	p.I232N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518311	7518311	p.I232N	c.695T>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518901	7518901	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-30-1862-01A-02W-0699-08	TCGA-30-1862-10A-01W-0699-08	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518901	7518901	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.672+1	e5+1	1	-	-	-	no_errors	TP53	17	7518901	7518901	p.?	c.672+1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518901	7518901	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-25-2400-01A-01W-0799-08	TCGA-25-2400-10A-01W-0799-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518901	7518901	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.672+1	e5+1	1	-	-	-	no_errors	TP53	17	7518901	7518901	p.?	c.672+1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518902	7518902	+	Silent	SNP	C	C	T	novel	Unknown	TCGA-25-2042-01A-01W-0799-08	TCGA-25-2042-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Capture,Sanger_PCR_WGA"			Illumina GAIIx	17	7518902	7518902	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	silent	c.672	p.E224	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518902	7518902	p.E224D	c.672G>C	
TP53	7157	broad.mit.edu	36	17	7518904	7518905	+	Frame_Shift_Del	DEL	CA	CA	-	novel	Unknown	TCGA-04-1357-01A-01W	TCGA-04-1357-11A-01W	CA	CA	-	-	CA	CA	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518904	7518905	CA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.670_669	p.E224fs	0.994:0.551	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518902,7519014])"	no_errors	TP53	17	7518904	7518904	p.E224K	c.670G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518907	7518908	+	Frame_Shift_Del	DEL	GC	GC	-	novel	Unknown	TCGA-09-2051-01A-01W-0799-08	TCGA-09-2051-10A-01W-0799-08	GC	GC	GC	-	GC	GC	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518907	7518908	GC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.667_666	p.P223fs	0.989:0.734	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518902,7519014])"	no_errors	TP53	17	7518907	7518907	p.P223fs*24	c.667delC	Unknown
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-59-2363-01A-01W-0799-08	TCGA-59-2363-10A-01W-0800-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-59-2350-01A-01W-0799-08	TCGA-59-2350-11A-01W-0800-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-0891-01A-01W	TCGA-13-0891-10A-01D	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-25-1319-01A-01W	TCGA-25-1319-10A-01W	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Broad454,Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-61-1728-01A-01W-0699-08	TCGA-61-1728-11A-01W-0700-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518929	7518929	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-61-1998-01A-01W-0722-08	TCGA-61-1998-10A-01W-0722-08	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518929	7518929	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.645	p.S215R	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518929	7518929	p.S215R	c.645T>A	Unknown
TP53	7157	broad.mit.edu	36	17	7518933	7518933	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-25-2404-01A-01W-0799-08	TCGA-25-2404-10A-01W-0799-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518933	7518933	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.641	p.H214R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518933	7518933	p.H214R	c.641A>G	Unknown
TP53	7157	broad.mit.edu	36	17	7518951	7518951	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-61-2092-01A-01W-0722-08	TCGA-61-2092-11A-01W-0722-08	T	T	A	A	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518951	7518951	T	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.623	p.D208V	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518951	7518951	p.D208V	c.623A>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518964	7518964	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-61-2016-01A-01W-0722-08	TCGA-61-2016-10A-01W-0722-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518964	7518964	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.610	p.E204*	0.4	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518964	7518964	p.E204*	c.610G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518964	7518964	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-61-2002-01A-01W-0722-08	TCGA-61-2002-11A-01W-0722-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518964	7518964	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.610	p.E204*	0.4	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518964	7518964	p.E204*	c.610G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518988	7518988	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-2289-01A-01W-0799-08	TCGA-24-2289-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7518988	7518988	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.586	p.R196*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518988	7518988	p.R196*	c.586C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518988	7518988	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0916-01A-01W	TCGA-13-0916-10A-01D	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518988	7518988	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.586	p.R196*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518988	7518988	p.R196*	c.586C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-25-2396-01A-01W-0799-08	TCGA-25-2396-10A-01W-0799-08	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518990	7518990	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195T	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-31-1950-01A-01W-0699-08	TCGA-31-1950-10A-01W-0699-08	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518990	7518990	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195T	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518990	7518990	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-61-1919-01A-01W-0699-08	TCGA-61-1919-11A-01W-0700-08	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518990	7518990	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.584	p.I195T	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518990	7518990	p.I195T	c.584T>C	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518991	7518991	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-1495-01A-01W	TCGA-13-1495-10A-01D	T	T	A	A	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518991	7518991	T	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.583	p.I195F	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518991	7518991	p.I195F	c.583A>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518991	7519015	+	Splice_Site	DEL	TAAGATGCTGAGGAGGGGCCAGACC	-	TAAGATGCTGAGGAGGGGCCAGACC	novel	Unknown	TCGA-09-2044-01B-01W-0799-08	TCGA-09-2044-10A-01W-0799-08	TAAGATGCTGAGGAGGGGCCAGACC	TAAGATGCTGAGGAGGGGCCAGACC	-	-	TAAGATGCTGAGGAGGGGCCAGACC	TAAGATGCTGAGGAGGGGCCAGACC	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518991	7519015	TAAGATGCTGAGGAGGGGCCAGACC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site_del	c.583_560	p.G187fs	1.000:0.987:1.000:1.000:0.996:1.000:1.000:1.000:1.000:1.000:0.998:0.999:0.987:0.923:0.995:0.997:0.888:0.996:0.996:0.816:0.467:0.381:0.265:0.331	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518902,7519014], intron[7519015,7519095])"	no_errors	TP53	17	7518991	7518991	p.I195F	c.583A>T	Unknown
TP53	7157	broad.mit.edu	36	17	7518993	7518993	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-30-1891-01A-01W-0699-08	TCGA-30-1891-10A-01W-0699-08	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518993	7518993	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.581	p.L194R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518993	7518993	p.L194R	c.581T>G	Unknown
TP53	7157	broad.mit.edu	36	17	7518993	7518993	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-25-2401-01A-01W-0799-08	TCGA-25-2401-10A-01W-0799-08	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518993	7518993	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.581	p.L194R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518993	7518993	p.L194R	c.581T>G	Unknown
TP53	7157	broad.mit.edu	36	17	7519000	7519000	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-1474-01A-01W	TCGA-24-1474-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519000	7519000	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.574	p.Q192*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519000	7519000	p.Q192*	c.574C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519000	7519002	+	In_Frame_Del	DEL	GAG	GAG	-	novel	Unknown	TCGA-24-1423-01A-01W	TCGA-24-1423-10A-01W	GAG	GAG	-	-	GAG	GAG	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7519000	7519002	GAG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.574_572	p.P191in_frame_del	1.000:0.998:0.999	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518902,7519014])"	no_errors	TP53	17	7519000	7519000	p.Q192*	c.574C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519000	7519002	+	In_Frame_Del	DEL	GAG	GAG	-	novel	Unknown	TCGA-24-0975-01B-02W	TCGA-24-0975-10B-01W	GAG	GAG	GAG	-	GAG	GAG	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7519000	7519002	GAG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.574_572	p.P191in_frame_del	1.000:0.998:0.999	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518902,7519014])"	no_errors	TP53	17	7519000	7519000	p.Q192*	c.574C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519015	7519015	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-24-0970-01B-01W	TCGA-24-0970-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture,Sequenom"			Illumina GAIIx	17	7519015	7519015	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.560-1	e5-1	0.38	-	-	-	no_errors	TP53	17	7519015	7519015	p.?	c.560-1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7519094	7519094	+	Splice_Site	SNP	A	A	C	novel	Unknown	TCGA-13-0923-01A-01W	TCGA-13-0923-10A-01D	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519094	7519094	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.559+2	e4+2	0.99	-	-	-	no_errors	TP53	17	7519094	7519094	p.?	c.559+2T>G	Unknown
TP53	7157	broad.mit.edu	36	17	7519095	7519095	+	Splice_Site	SNP	C	C	T	novel	Unknown	TCGA-24-2030-01A-01W-0722-08	TCGA-24-2030-10A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519095	7519095	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.559+1	e4+1	1	-	-	-	no_errors	TP53	17	7519095	7519095	p.?	c.559+1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7519095	7519095	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-24-1564-01A-01W	TCGA-24-1564-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519095	7519095	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.559+1	e4+1	1	-	-	-	no_errors	TP53	17	7519095	7519095	p.?	c.559+1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7519095	7519095	+	Splice_Site	SNP	C	C	A	novel	Unknown	TCGA-13-1492-01A-01D	TCGA-13-1492-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519095	7519095	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.559+1	e4+1	1	-	-	-	no_errors	TP53	17	7519095	7519095	p.?	c.559+1G>A	Unknown
TP53	7157	broad.mit.edu	36	17	7519119	7519119	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-2060-01A-01W-0799-08	TCGA-13-2060-10A-01W-0799-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519119	7519119	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.536	p.H179R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519119	7519119	p.H179R	c.536A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519119	7519119	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-09-2045-01A-01W-0799-08	TCGA-09-2045-11A-01W-0799-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519119	7519119	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.536	p.H179R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519119	7519119	p.H179R	c.536A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-23-1110-01A-01D	TCGA-23-1110-10A-01D	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519128	7519128	p.C176Y	c.527G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-23-1122-01A-01W	TCGA-23-1122-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-23-1030-01A-02W	TCGA-23-1030-10C-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-61-2003-01A-01W-0722-08	TCGA-61-2003-10A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-25-2399-01A-01W-0799-08	TCGA-25-2399-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-24-2281-01A-01W-0799-08	TCGA-24-2281-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-23-2077-01A-01W-0722-08	TCGA-23-2077-10A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519131	7519131	p.R175H	c.524G>A	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519167	7519167	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-10-0926-01A-01W	TCGA-10-0926-11A-01D	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519167	7519167	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.488	p.Y163C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519167	7519167	p.Y163C	c.488A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519167	7519167	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-2261-01A-01W-0722-08	TCGA-24-2261-11A-01W-0722-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519167	7519167	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.488	p.Y163C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519167	7519167	p.Y163C	c.488A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519168	7519168	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-61-2104-01A-01W-0722-08	TCGA-61-2104-11A-01W-0723-08	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7519168	7519168	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.487	p.Y163N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519168	7519168	p.Y163H	c.487T>C	Unknown
TP53	7157	broad.mit.edu	36	17	7519168	7519168	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-09-2053-01C-01W-0722-08	TCGA-09-2053-10A-01W-0722-08	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519168	7519168	A	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.487	p.Y163H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519168	7519168	p.Y163H	c.487T>C	Unknown
TP53	7157	broad.mit.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-61-2009-01A-01W-0722-08	TCGA-61-2009-10A-01W-0722-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519186	7519186	p.V157F	c.469G>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519221	7519221	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-25-1313-01A-01W	TCGA-25-1313-10A-01W	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519221	7519221	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.434	p.L145R	0.98	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519221	7519221	p.L145Q	c.434T>A	Unknown
TP53	7157	broad.mit.edu	36	17	7519221	7519221	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-13-1501-01A-01W	TCGA-13-1501-10A-01W	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519221	7519221	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.434	p.L145Q	0.98	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519221	7519221	p.L145Q	c.434T>A	Unknown
TP53	7157	broad.mit.edu	36	17	7519225	7519225	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-20-0990-01A-01W	TCGA-20-0990-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519225	7519225	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.430	p.Q144*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519225	7519225	p.Q144*	c.430C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519235	7519235	+	Frame_Shift_Del	DEL	G	-	G	novel	Unknown	TCGA-59-2351-01A-01W-0799-08	TCGA-59-2351-10A-01W-0800-08	G	G	-	-	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7519235	7519235	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.420	p.C141fs	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	17	7519235	7519235	p.T140T	c.420C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7519230	7519244	+	In_Frame_Del	DEL	GGGCAGGTCTTGGCC	GGGCAGGTCTTGGCC	-	novel	Unknown	TCGA-25-2393-01A-01W-0799-08	TCGA-25-2393-10A-01W-0799-08	GGGCAGGTCTTGGCC	GGGCAGGTCTTGGCC	-	-	GGGCAGGTCTTGGCC	GGGCAGGTCTTGGCC	Unknown	Unknown	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7519230	7519244	GGGCAGGTCTTGGCC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.425_411	p.AKTCP138in_frame_del	0.999:1.000:1.000:1.000:1.000:0.996:1.000:1.000:1.000:1.000:1.000:0.994:1.000:1.000:0.985	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	17	7519230	7519230	p.P142H	c.425C>A	
TP53	7157	broad.mit.edu	36	17	7519249	7519249	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-10-0931-01A-01W	TCGA-10-0931-11A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519249	7519249	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.406	p.Q136*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519249	7519249	p.Q136*	c.406C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7519259	7519259	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-2262-01A-01W-0799-08	TCGA-24-2262-11A-01W-0799-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519259	7519259	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.396	p.K132N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519259	7519259	p.K132N	c.396G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7519261	7519261	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-61-2000-01A-01W-0722-08	TCGA-61-2000-11A-01W-0722-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7519261	7519261	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.394	p.K132E	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519261	7519261	p.K132E	c.394A>G	Unknown
TP53	7157	broad.mit.edu	36	17	7519266	7519267	+	Frame_Shift_Ins	INS	-	-	GG	novel	Unknown	TCGA-13-1410-01A-01W	TCGA-13-1410-10A-01W	-	-	GG	GG	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7519266	7519267	-	GG	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.389_388	p.L130fs	0.974:0.951	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519266	7519266	p.L130R	c.389T>G	Unknown
TP53	7157	broad.mit.edu	36	17	7519267	7519267	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-61-2094-01A-01W-0722-08	TCGA-61-2094-11A-01W-0722-08	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7519267	7519267	G	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.388	p.L130V	0.95	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519267	7519267	p.L130V	c.388C>G	Unknown
TP53	7157	broad.mit.edu	36	17	7519275	7519275	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-61-2110-01A-01W-0722-08	TCGA-61-2110-11A-01W-0723-08	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519275	7519275	G	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.380	p.S127Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519275	7519275	p.S127F	c.380C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7520040	7520040	+	Frame_Shift_Del	DEL	G	-	G	novel	Unknown	TCGA-25-1320-01A-01W	TCGA-25-1320-10A-01W	G	G	-	-	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7520040	7520040	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.372	p.C124fs	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520040	7520039	p.T125fs*24	c.372_373insN	Unknown
TP53	7157	broad.mit.edu	36	17	7520060	7520061	+	Frame_Shift_Ins	INS	-	C	-	novel	Unknown	TCGA-61-2008-01A-02W-0722-08	TCGA-61-2008-11A-01W-0722-08	-	-	C	C	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7520060	7520061	-	C	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.352_351	p.T117fs	1.000:0.979	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520060	7520060	p.T118A	c.352A>G	Unknown
TP53	7157	broad.mit.edu	36	17	7520087	7520121	+	Frame_Shift_Del	DEL	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	-	novel	Unknown	TCGA-31-1953-01A-01W-0699-08	TCGA-31-1953-10A-01W-0699-08	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	-	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7520087	7520121	AACCGTAGCTGCCCTGGTAGGTTTTCTGGGAAGGG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.325_291	p.Q100fs	0.330:0.183:0.165:0.162:0.166:0.178:0.151:0.019:0.003:0.025:0.345:0.734:0.731:0.078:0.860:0.941:0.999:0.999:0.993:0.668:0.645:0.642:0.600:0.610:0.602:0.560:0.575:0.595:0.590:0.909:0.938:0.944:1.000:1.000:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520087	7520082	p.F109_R110delFR	c.325_330delTTCCGT	Unknown
TP53	7157	broad.mit.edu	36	17	7520099	7520099	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-20-0987-01A-02W	TCGA-20-0987-10A-01W	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7520099	7520099	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.313	p.G105R	0.73	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520099	7520099	p.G105C	c.313G>T	Confirmed
TP53	7157	broad.mit.edu	36	17	7520099	7520099	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-1494-01A-01W	TCGA-13-1494-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7520099	7520099	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.313	p.G105C	0.73	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520099	7520099	p.G105C	c.313G>T	Confirmed
TP53	7157	broad.mit.edu	36	17	7520148	7520157	+	Frame_Shift_Del	DEL	GGCTGGTGCA	-	-	novel	Unknown	TCGA-61-2101-01A-01W-0722-08	TCGA-61-2101-11A-01W-0723-08	GGCTGGTGCA	GGCTGGTGCA	-	-	GGCTGGTGCA	GGCTGGTGCA	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7520148	7520157	GGCTGGTGCA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.264_255	p.A86fs	1.000:1.000:1.000:1.000:1.000:0.984:0.662:0.689:0.520:0.508	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520148	7520147	p.P89fs*60	c.264_265insN	Unknown
TP53	7157	broad.mit.edu	36	17	7520187	7520187	+	Frame_Shift_Del	DEL	A	-	-	novel	Unknown	TCGA-13-1505-01A-01D	TCGA-13-1505-10A-01D	A	A	-	-	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7520187	7520187	A	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.225	p.A76fs	0.05	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520187	7520188	p.A76fs*73	c.225_226insT	Unknown
TP53	7157	broad.mit.edu	36	17	7520260	7520261	+	Frame_Shift_Ins	INS	-	-	C	novel	Unknown	TCGA-25-2391-01A-01W-0799-08	TCGA-25-2391-10A-01W-0799-08	-	-	-	C	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7520260	7520261	-	C	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.152_151	p.E51fs	0.000:0.000	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520261	7520261	p.E51*	c.151G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7520272	7520272	+	Frame_Shift_Del	DEL	G	G	-	novel	Unknown	TCGA-25-1329-01A-01W	TCGA-25-1329-10A-01W	G	G	-	-	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7520272	7520272	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.140	p.P47fs	0	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520272	7520272	p.P47fs*76	c.140delC	Unknown
TP53	7157	broad.mit.edu	36	17	7520281	7520285	+	Frame_Shift_Del	DEL	ATCAA	-	ATCAA	novel	Unknown	TCGA-13-0911-01A-01W	TCGA-13-0911-10A-01D	ATCAA	ATCAA	-	-	ATCAA	ATCAA	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7520281	7520285	ATCAA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.131_127	p.L43fs	0.067:0.089:0.152:0.176:0.168	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520281	7520281	p.M44T	c.131T>C	Unknown
NF1	4763	broad.mit.edu	36	17	26609644	26609644	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-04-1331-01A-01W	TCGA-04-1331-10A-01W	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	26609644	26609644	A	G	SNP	NF1	NM_001042492	human	genbank	54_36p	1	reviewed	missense	c.4330	p.K1444E	1	"HMMPfam_RasGAP,HMMSmart_SM00323,superfamily_GTPase activation domain GAP"	"HMMSmart_SM00516,HMMPfam_RasGAP,HMMSmart_SM00323,PatternScan_RAS_GTPASE_ACTIV_1,superfamily_GTPase activation domain GAP"	-	no_errors	NF1	17	26609644	26609644	p.K1444E	c.4330A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7517625	7517626	+	Frame_Shift_Del	DEL	GA	-	-	novel	Unknown	TCGA-24-2035-01A-01W-0722-08	TCGA-24-2035-10A-01W-0722-08	GA	GA	GA	-	GA	GA	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7517625	7517626	GA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.946_945	p.Q317fs	0.962:0.964	NULL	"HMMPfam_P53_TAD,HMMPfam_P53,superfamily_p53-like transcription factors,PatternScan_P53,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"(deletion:cds_exon[7517578,7517651])"	no_errors	TP53	17	7517625	7517624	p.Q317fs*19	c.946_947delCC	Unknown
TP53	7157	broad.mit.edu	36	17	7517800	7517801	+	Frame_Shift_Ins	INS	-	T	T	novel	Unknown	TCGA-04-1342-01A-01W	TCGA-04-1342-11A-01W	-	-	-	T	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7517800	7517801	-	T	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.863_862	p.N288fs	0.940:0.933	HMMPfam_P53	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517800	7517800	p.N288S	c.863A>G	Unknown
TP53	7157	broad.mit.edu	36	17	7518335	7518335	+	Splice_Site	SNP	T	C	C	novel	Unknown	TCGA-24-2298-01A-01W-0799-08	TCGA-24-2298-11A-01W-0799-08	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518335	7518335	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site	c.673-2	e6-2	0.99	-	-	-	no_errors	TP53	17	7518335	7518335	p.?	c.673-2A>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-59-2354-01A-01W-0799-08	TCGA-59-2354-11A-01W-0800-08	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-61-2012-01A-01W-0722-08	TCGA-61-2012-11A-01W-0722-08	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-04-1356-01A-01W	TCGA-04-1356-11A-01W	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518915	7518915	p.Y220C	c.659A>G	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518937	7518937	+	Nonsense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-13-1510-01A-02D	TCGA-13-1510-10A-01W	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518937	7518937	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.637	p.R213*	0.38	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518937	7518937	p.R213*	c.637C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7518982	7518982	+	Nonsense_Mutation	SNP	C	A	A	novel	Unknown	TCGA-23-1027-01A-02W	TCGA-23-1027-10A-01W	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518982	7518982	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.592	p.E198*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518982	7518982	p.E198*	c.592G>T	Unknown
TP53	7157	broad.mit.edu	36	17	7519000	7519000	+	Nonsense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-24-2280-01A-01W-0799-08	TCGA-24-2280-10A-01W-0799-08	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7519000	7519000	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.574	p.Q192*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519000	7519000	p.Q192*	c.574C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519000	7519000	+	Nonsense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-24-1431-01A-01D	TCGA-24-1431-10A-01D	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7519000	7519000	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.574	p.Q192*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519000	7519000	p.Q192*	c.574C>T	Previously Observed
TP53	7157	broad.mit.edu	36	17	7519193	7519194	+	In_Frame_Ins	INS	-	CCGGGCGGGGGTGTGGAATCAGTG	CCGGGCGGGGGTGTGGAATCAGTG	novel	Unknown	TCGA-25-2398-01A-01W-0799-08	TCGA-25-2398-10A-01W-0799-08	-	-					Unknown	Unknown	Somatic	Phase_I	Capture				Illumina GAIIx	17	7519193	7519194	-	CCGGGCGGGGGTGTGGAATCAGTG	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_ins	c.462_461	p.156in_frame_insDSTPPPGT	0.001:0.496	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519193	7519193	p.G154G	c.462C>T	Unknown
TP53	7157	broad.mit.edu	36	17	7520032	7520032	+	Splice_Region	SNP	C	A	A	novel	Unknown	TCGA-23-2079-01A-01W-0722-08	TCGA-23-2079-10A-01W-0722-08	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7520032	7520032	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_region	c.375+5	e3+5	1	-	-	-	no_errors	TP53	17	7520041	7520041	p.C124S	c.371G>C	
TP53	7157	genome.wustl.edu	36	17	7517815	7517816	+	Frame_Shift_Ins	INS	-	A	A	novel	Unknown	TCGA-13-0897-01A-01W-0421-09	TCGA-13-0897-10A-01W-0421-09	-	-	-	A	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517815	7517816	-	A	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.848_847	p.R283fs	0.013:0.012	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517815	7517815	p.R283P	c.848G>C	Unknown
TP53	7157	genome.wustl.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-24-1417-01A-01W-0549-09	TCGA-24-1417-10A-01W-0549-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7518264	7518264	p.R248W	c.742C>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7519195	7519207	+	Frame_Shift_Del	DEL	CGGGCGGGGGTGT	-	-	novel	Unknown	TCGA-13-0723-01A-02W-0372-09	TCGA-13-0723-10B-01W-0372-09	CGGGCGGGGGTGT	CGGGCGGGGGTGT	CGGGCGGGGGTGT	-	CGGGCGGGGGTGT	CGGGCGGGGGTGT	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519195	7519207	CGGGCGGGGGTGT	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.460_448	p.T150fs	0.496:0.001:0.001:0.001:0.001:0.996:0.998:0.906:0.998:0.997:0.001:0.001:0.001	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	17	7519195	7519187	p.G154_R156delGTR	c.460_468delGGCACCCGC	Unknown
TP53	7157	genome.wustl.edu	36	17	7520032	7520032	+	Splice_Region	SNP	C	G	G	novel	Unknown	TCGA-10-0930-01A-02W-0421-09	TCGA-10-0930-11A-01W-0977-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7520032	7520032	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_region	c.375+5	e3+5	1	-	-	-	no_errors	TP53	17	7520041	7520041	p.C124S	c.371G>C	
TP53	7157	hgsc.bcm.edu	36	17	7514743	7514743	+	Frame_Shift_Del	DEL	G	-	-	novel	Unknown	TCGA-36-1576-01A-01W-0615-10	TCGA-36-1576-10A-01W-0615-10	G	G	G	-	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7514743	7514743	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.1009	p.R337fs	0.47	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7514652,7514758])"	no_errors	TP53	17	7514743	7514743	p.R337C	c.1009C>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-36-1574-01A-01W-0615-10	TCGA-36-1574-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7517845	7517845	p.R273H	c.818G>A	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7518270	7518275	+	In_Frame_Del	DEL	TGCCGC	-	-	novel	Unknown	TCGA-13-0717-01A-01W-0370-10	TCGA-13-0717-10B-01W-0370-10	TGCCGC	TGCCGC	TGCCGC	-	TGCCGC	TGCCGC	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7518270	7518275	TGCCGC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.736_731	p.GGM244in_frame_delV	1.000:1.000:1.000:0.996:0.171:0.996	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	17	7518270	7518270	p.M246V	c.736A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520083	7520083	+	Missense_Mutation	SNP	C	A	A	rs11540654	byCluster;byHapMap	TCGA-23-1120-01A-02W-0484-10	TCGA-23-1120-10A-01W-0484-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7520083	7520083	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.329	p.R110L	0.02	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520083	7520083	p.R110L	c.329G>T	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7520201	7520202	+	Frame_Shift_Del	DEL	GA	-	-	novel	Unknown	TCGA-25-1634-01A-01W-0615-10	TCGA-25-1634-10A-01W-0616-10	GA	GA	-	-	GA	GA	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7520201	7520202	GA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.211_210	p.P72fs	0.662:0.662	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520201	7520201	p.R72fs*51	c.211delC	Previously Observed
TP53	7157	hgsc.bcm.edu	36	17	7520294	7520306	+	Frame_Shift_Del	DEL	TTGCTTGGGACGG	-	-	novel	Unknown	TCGA-10-0927-01A-02W-0419-10	TCGA-10-0927-11A-01W-0419-10	TTGCTTGGGACGG	TTGCTTGGGACGG	TTGCTTGGGACGG	-	TTGCTTGGGACGG	TTGCTTGGGACGG	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7520294	7520306	TTGCTTGGGACGG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.118_106	p.P36fs	0.000:0.000:0.001:0.000:0.000:0.001:0.001:0.002:0.000:0.000:0.000:0.000:0.000	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	17	7520298	7520298	p.A39fs*5	c.114delA	Unknown
TP53	7157	genome.wustl.edu	36	17	7520228	7520228	+	Missense_Mutation	SNP	C	T	T	novel	Unknown	TCGA-13-1506-01A-01W-0549-09	TCGA-13-1506-10A-01W-0550-09	C	C	T	T	C	C	Unknown	Unknown	Somatic	Phase_I	Capture		1	dbGAP	Illumina GAIIx	17	7520228	7520228	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.184	p.E62K	0.02	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520228	7520228	p.E62*	c.184G>T	Previously Observed
TP53	7157	genome.wustl.edu	36	17	7520215	7520216	+	Frame_Shift_Ins	INS	-	ATTCTGGG	ATTCTGGG	novel	Unknown	TCGA-13-1506-01A-01W-0549-09	TCGA-13-1506-10A-01W-0550-09	-	-	ATTCTGGG	ATTCTGGG	-	-	Unknown	Unknown	Somatic	Phase_I	Capture		1	dbGAP	Illumina GAIIx	17	7520215	7520216	-	ATTCTGGG	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.197_196	p.M66fs	0.005:0.007	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7520215	7520215	p.M66R	c.197T>G	Unknown
TP53	7157	genome.wustl.edu	36	17	7518315	7518346	+	Splice_Site	DEL	TGGTACAGTCAGAGCCAACCTAGGAGATAACA	G	G	novel	Unknown	TCGA-24-1549-01A-01W-0553-09	TCGA-24-1549-10A-01W-0553-09	TGGTACAGTCAGAGCCAACCTAGGAGATAACA	TGGTACAGTCAGAGCCAACCTAGGAGATAACA					Unknown	Unknown	Somatic	Phase_I	Capture		1	dbGAP	Illumina GAIIx	17	7518315	7518346	TGGTACAGTCAGAGCCAACCTAGGAGATAAC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site_del	c.691_673	p.VGSDCTTIHY225in_frame_delPSTT	1.000:1.000:1.000:1.000:0.995:0.995:0.997:0.984:1.000:0.998:0.801:0.967:0.950:0.950:0.983:0.982:0.590:0.784:0.836	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333], intron[7518334,7518901])"	no_errors	TP53	17	7518315	7518315	p.T231A	c.691A>G	Unknown
TP53	7157	hgsc.bcm.edu	36	17	7519099	7519099	+	Missense_Mutation	SNP	C	T	T	novel	Unknown	TCGA-10-0928-01A-02W-0419-10	TCGA-10-0928-11A-01W-0419-10	C	C	C	C	C	C	Unknown	None	Wildtype	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7519099	7519099	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.556	p.D186N	0	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	17	7519099	7519099	p.D186N	c.556G>A	Unknown


Mutations with OMIM Hits																																																											
Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error comment	OMIM_gene	OMIM_entry	OMIM_residue	OMIM_aa1	OMIM_aa2	OMIM_disorders	
KCNQ1	3784	genome.wustl.edu	36	11	2561263	2561263	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-13-0726-01A-01W-0372-09	TCGA-13-0726-10B-01W-0977-09	A	A	A	T	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	11	2561263	2561263	A	T	SNP	KCNQ1	NM_000218	human	genbank	54_36p	1	reviewed	missense	c.944	p.Y315F	1	"superfamily_Voltage-gated potassium channels,HMMPfam_Ion_trans"	"superfamily_Voltage-gated potassium channels,HMMPfam_Ion_trans,HMMPfam_KCNQ_channel"	-	no_errors	KCNQ1	607542.0012	314	G	S	"Long QT syndrome-1; Jervell and Lange-Nielsen syndrome; Atrial fibrillation, familial, 3; Short QT syndrome-2; Long QT syndrome 1, acquired, susceptibility to,"	
MS4A2	2206	genome.wustl.edu	36	11	59619683	59619683	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-23-1117-01A-02W-0488-09	TCGA-23-1117-10A-01W-0488-09	T	T	T	C	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	11	59619683	59619683	T	C	SNP	MS4A2	NM_000139	human	genbank	54_36p	1	reviewed	missense	c.713	p.M238T	0	NULL	HMMPfam_CD20	-	no_errors	MS4A2	147138.0001	237	E	G	"Atopy, susceptibility to,"	
PAH	5053	genome.wustl.edu	36	12	101812699	101812706	+	Frame_Shift_Del	DEL	CTCAAGAT	CTCAAGAT	-	novel	Unknown	TCGA-13-0924-01A-01W-0421-09	TCGA-13-0924-10A-01W-0421-09	CTCAAGAT	CTCAAGAT	CTCAAGAT	-	CTCAAGAT	CTCAAGAT	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	12	101812699	101812706	CTCAAGAT	-	DEL	PAH	NM_000277	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.296_289	p.I97fs	0.997:1.000:1.000:1.000:1.000:1.000:1.000:1.000	"superfamily_SSF55021,HMMPfam_ACT"	"superfamily_SSF55021,HMMPfam_ACT,superfamily_Aaa_hydroxylase,HMMPfam_Biopterin_H,PatternScan_BIOPTERIN_HYDROXYL"	"(deletion:cds_exon[101812643,101812826])"	no_errors	PAH	612349.0053	98	L	S	"Phenylketonuria; Hyperphenylalaninemia, non-PKU mild,"	
KRAS	3845	genome.wustl.edu	36	12	25289551	25289551	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1316-01A-01W-0494-09	TCGA-25-1316-10A-01W-0494-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	12	25289551	25289551	C	A	SNP	KRAS	NM_033360	human	genbank	54_36p	-1	reviewed	missense	c.35	p.G12V	1	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	-	no_errors	KRAS	190070.0008	11	G	-	"Lung cancer; Bladder cancer; Breast cancer, somatic; Pancreatic carcinoma, somatic; Stomach cancer; Leukemia, acute myelogenous; Noonan syndrome 3; Cardiofaciocutaneous syndrome,"	
CHRNA1	1134	genome.wustl.edu	36	2	175326448	175326448	+	Nonsense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-24-1427-01A-01W-0549-09	TCGA-24-1427-10A-01W-0549-09	G	G	G	T	G	G	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	2	175326448	175326448	G	T	SNP	CHRNA1	ENST00000409323	human	ensembl	54_36p	-1	known	nonsense	c.807	p.C269*	0	NULL	"superfamily_Nicotinic receptor ligand binding domain-like,HMMPfam_Neur_chan_LBD,PatternScan_NEUROTR_ION_CHANNEL,superfamily_Neurotransmitter-gated ion-channel transmembrane pore,HMMPfam_Neur_chan_memb"	-	no_errors	CHRNA1	100690.0005	269	S	I	"Myasthenic syndrome, slow-channel congenital; Myasthenic syndrome, fast-channel congenital; Multiple pterygium syndrome, lethal type,"	
GNAS	2778	genome.wustl.edu	36	20	56913889	56913889	+	Nonsense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-23-1123-01A-01W-0488-09	TCGA-23-1123-10A-01W-0488-09	C	C	C	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	20	56913889	56913889	C	G	SNP	GNAS	NM_001077488	human	genbank	54_36p	1	reviewed	nonsense	c.492	p.Y164*	0.98	"HMMPfam_G-alpha,superfamily_SSF52540,superfamily_Transducn_insert"	"HMMPfam_G-alpha,superfamily_SSF52540,superfamily_Transducn_insert"	-	no_errors	GNAS	139320.0007	165	C	R	"Pseudohypoparathyroidism Ia; McCune-Albright syndrome; Pseudohypoparathyroidism Ic; Osseous heteroplasia, progressive; Pseudohypoparathyroidism Ib; Prolonged bleeding time, brachydactyly and mental retardation; Acromegaly; Pseudopseudohypoparathyroidism,"	
CASR	846	genome.wustl.edu	36	3	123458629	123458629	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-1497-01A-01W-0549-09	TCGA-13-1497-10A-01W-0549-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	123458629	123458629	G	A	SNP	CASR	NM_000388	human	genbank	54_36p	1	reviewed	missense	c.197	p.R66H	1	superfamily_Periplasmic binding protein-like I	"superfamily_Periplasmic binding protein-like I,HMMPfam_ANF_receptor,PatternScan_G_PROTEIN_RECEP_F3_1,HMMPfam_NCD3G,PatternScan_G_PROTEIN_RECEP_F3_2,HMMPfam_7tm_3,PatternScan_G_PROTEIN_RECEP_F3_3"	-	no_errors	CASR	601199.0026	67	R	C	"Hypocalciuric hypercalcemia, type I; Hyperparathyroidism, neonatal; Hypocalcemia, autosomal dominant; Hypocalcemia, autosomal dominant, with Bartter syndrome; Epilepsy, idiopathic generalized, susceptibility to, 8,"	
SLC2A2	6514	genome.wustl.edu	36	3	172207654	172207654	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0795-01A-01W-0372-09	TCGA-13-0795-10A-01W-0372-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	172207654	172207654	C	T	SNP	SLC2A2	NM_000340	human	genbank	54_36p	-1	reviewed	missense	c.589	p.V197I	1	"superfamily_MFS_gen_substrate_transporter,HMMPfam_Sugar_tr"	"superfamily_MFS_gen_substrate_transporter,HMMPfam_Sugar_tr,PatternScan_SUGAR_TRANSPORT_2,PatternScan_SUGAR_TRANSPORT_1"	-	no_errors	SLC2A2	138160.0001	197	V	I	"Diabetes mellitus, noninsulin-dependent; Fanconi-Bickel syndrome,"	
PIK3CA	5290	genome.wustl.edu	36	3	180418785	180418785	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0800-01A-01W-0372-09	TCGA-13-0800-10A-01W-0372-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	180418785	180418785	G	A	SNP	PIK3CA	NM_006218	human	genbank	54_36p	1	reviewed	missense	c.1633	p.E545K	1	"HMMPfam_PI3Ka,HMMSmart_PI3Ka,superfamily_ARM-type_fold"	###############################################################################################################################################################################################################################################################	-	no_errors	PIK3CA	171834.0008	545	E	A	"Ovarian cancer, somatic; Breast cancer, somatic; Colorectal cancer, somatic; Gastric cancer, somatic; Hepatocellular carcinoma, somatic; Nonsmall cell lung cancer, somatic; Keratosis, seborrheic, somatic; Nevus, epidermal,"	
PIK3CA	5290	genome.wustl.edu	36	3	180434779	180434779	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-24-1416-01A-01W-0549-09	TCGA-24-1416-10A-01W-0549-09	A	A	A	G	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	3	180434779	180434779	A	G	SNP	PIK3CA	NM_006218	human	genbank	54_36p	1	reviewed	missense	c.3140	p.H1047R	1	"HMMSmart_PI3Kc,superfamily_Kinase_like"	###############################################################################################################################################################################################################################################################	-	no_errors	PIK3CA	171834.0002	1047	H	L	"Ovarian cancer, somatic; Breast cancer, somatic; Colorectal cancer, somatic; Gastric cancer, somatic; Hepatocellular carcinoma, somatic; Nonsmall cell lung cancer, somatic; Keratosis, seborrheic, somatic; Nevus, epidermal,"	
KLKB1	3818	genome.wustl.edu	36	4	187392185	187392185	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1463-01A-01W-0549-09	TCGA-24-1463-10A-01W-0549-09	C	C					Unknown	Unknown	Somatic	4	Capture		1	dbGAP	Illumina GAIIx	4	187392185	187392185	C	A	SNP	KLKB1	NM_000892	human	genbank	54_36p	1	reviewed	missense	c.307	p.Q103K	1	"HMMSmart_APPLE,PatternScan_APPLE,HMMPfam_PAN_1"	"HMMSmart_APPLE,PatternScan_APPLE,HMMPfam_PAN_1,superfamily_Pept_Ser_Cys,HMMSmart_Tryp_SPc,HMMPfam_Trypsin,PatternScan_TRYPSIN_HIS,PatternScan_TRYPSIN_SER"	-	no_errors	KLKB1	229000.0004	104	G	R	"Fletcher factor deficiency,"	
APC	324	genome.wustl.edu	36	5	112202549	112202549	+	Missense_Mutation	SNP	G	G	A	rs28933379	Unknown	TCGA-23-1022-01A-02W-0488-09	TCGA-23-1022-10A-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	5	112202549	112202549	G	A	SNP	APC	NM_000038	human	genbank	54_36p	1	reviewed	missense	c.3359	p.G1120E	1	NULL	"superfamily_ARM repeat,HMMSmart_SM00185,HMMPfam_Arm,HMMPfam_APC_15aa,HMMPfam_APC_crr,HMMPfam_SAMP,HMMPfam_APC_basic,HMMPfam_EB1_binding"	-	no_errors	APC	611731.0010	1120	G	E	"Adenomatous polyposis coli; Gastric cancer, somatic; Adenoma, periampullary; Hepatoblastoma; Desmoid disease, hereditary; Gardner syndrome; Brain tumor-polyposis syndrome; Colorectal cancer, somatic,"	
HEXB	3074	genome.wustl.edu	36	5	74050387	74050387	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-24-1469-01A-01W-0553-09	TCGA-24-1469-10A-01W-0553-09	G	G	G	C	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	5	74050387	74050387	G	C	SNP	HEXB	NM_000521	human	genbank	54_36p	1	reviewed	missense	c.1252	p.G418R	0.98	"HMMPfam_Glyco_hydro_20,superfamily_(Trans)glycosidases"	"superfamily_beta-N-acetylhexosaminidase-like domain,HMMPfam_Glyco_hydro_20b,HMMPfam_Glyco_hydro_20,superfamily_(Trans)glycosidases"	-	no_errors	HEXB	606873.0007	417	P	L	"Sandhoff disease, infantile, juvenile, and adult forms,"	
PRPH2	5961	genome.wustl.edu	36	6	42780284	42780284	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0920-01A-01W-0421-09	TCGA-13-0920-10A-01W-0421-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	6	42780284	42780284	C	T	SNP	PRPH2	NM_000322	human	genbank	54_36p	-1	reviewed	missense	c.625	p.V209I	1	"HMMPfam_Tetraspannin,superfamily_Tetraspanin,PatternScan_RDS_ROM1"	"HMMPfam_Tetraspannin,superfamily_Tetraspanin,PatternScan_RDS_ROM1"	-	no_errors	PRPH2	179605.0012	210	P	R	###############################################################################################################################################################################################################################################################
EFHC1	114327	genome.wustl.edu	36	6	52425561	52425561	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-1488-01A-01W-0549-09	TCGA-13-1488-10A-01W-0549-09	T	T	T	A	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	6	52425561	52425561	T	A	SNP	EFHC1	NM_018100	human	genbank	54_36p	1	validated	missense	c.690	p.D230E	1	NULL	"HMMSmart_SM00676,HMMPfam_DUF1126,superfamily_EF-hand,HMMPfam_efhand"	-	no_errors	EFHC1	608815.0002	229	F	L	"Myoclonic epilepsy, juvenile, susceptibility to, 1; Epilepsy, juvenile absence, susceptibility to, 1,"
CFTR	1080	genome.wustl.edu	36	7	116958238	116958238	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0800-01A-01W-0372-09	TCGA-13-0800-10A-01W-0372-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	7	116958238	116958238	C	A	SNP	CFTR	NM_000492	human	genbank	54_36p	1	reviewed	missense	c.323	p.S108Y	1	"superfamily_Multidrug resistance ABC transporter MsbA N-terminal domain,HMMPfam_ABC_membrane"	"superfamily_Multidrug resistance ABC transporter MsbA N-terminal domain,HMMPfam_ABC_membrane,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00382,HMMPfam_ABC_tran,PatternScan_ABC_TRANSPORTER_1"	-	no_errors	CFTR	602421.0091	109	Y	C	"Cystic fibrosis; Congenital bilateral absence of vas deferens; Sweat chloride elevation without CF; Pancreatitis, idiopathic; Hypertrypsinemia, neonatal; Bronchiectasis with or without elevated sweat chloride 1, modifier of,"
BRAF	673	genome.wustl.edu	36	7	140095638	140095638	+	Nonsense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-04-1347-01A-01W-0488-09	TCGA-04-1347-11A-01W-0489-09	G	G	G	C	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	7	140095638	140095638	G	C	SNP	BRAF	NM_004333	human	genbank	54_36p	-1	reviewed	nonsense	c.1910	p.S637*	1	"superfamily_Protein kinase-like (PK-like),HMMSmart_SM00219,HMMPfam_Pkinase,HMMSmart_SM00220"	###############################################################################################################################################################################################################################################################	-	no_errors	BRAF	164757.0021	638	D	E	"Melanoma, malignant, somatic; Colorectal cancer, somatic; Adenocarcinoma of lung, somatic; Nonsmall cell lung cancer, somatic; Cardiofaciocutaneous syndrome,"
BTK	695	genome.wustl.edu	36	X	100494971	100494971	+	Missense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-13-1489-01A-01W-0549-09	TCGA-13-1489-10A-01W-0549-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	X	100494971	100494971	G	A	SNP	BTK	NM_000061	human	genbank	54_36p	-1	reviewed	missense	c.1775	p.S592F	1	"superfamily_Kinase_like,HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc"	###############################################################################################################################################################################################################################################################	-	no_errors	BTK	300300.0045	591	Y	*	"Agammaglobulinemia, type 1, X-linked; Agammaglobulinemia and isolated hormone deficiency,"
AR	367	genome.wustl.edu	36	X	66854056	66854056	+	Missense_Mutation	SNP	T	T	A	novel	Unknown	TCGA-13-0760-01A-01W-0372-09	TCGA-13-0760-10A-01W-0372-09	T	T	T	A	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	X	66854056	66854056	T	A	SNP	AR	NM_000044	human	genbank	54_36p	1	reviewed	missense	c.2185	p.L729I	0.98	"superfamily_Nuclear receptor ligand-binding domain,HMMSmart_SM00430,HMMPfam_Hormone_recep"	"HMMPfam_Androgen_recep,HMMSmart_SM00399,HMMPfam_zf-C4,superfamily_Glucocorticoid receptor-like (DNA-binding domain),PatternScan_NUCLEAR_REC_DBD_1,superfamily_Nuclear receptor ligand-binding domain,HMMSmart_SM00430,HMMPfam_Hormone_recep"	-	no_errors	AR	313700.0013	730	V	M	"Androgen insensitivity; Spinal and bulbar muscular atrophy of Kennedy; Androgen insensitivity, partial, with or without breast cancer; Prostate cancer, susceptibility to; Hypospadias 1, X-linked,"
EDA	1896	hgsc.bcm.edu	36	X	68753061	68753061	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0762-01A-01W-0370-10	TCGA-13-0762-10A-01W-0370-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	X	68753061	68753061	C	A	SNP	EDA	NM_001399	human	genbank	54_36p	1	reviewed	missense	c.184	p.L62I	1	NULL	"HMMPfam_Collagen,superfamily_TNF-like,HMMPfam_TNF"	-	no_errors	EDA	300451.0011	61	Y	*	"Ectodermal dysplasia, anhidrotic, X-linked; Tooth agenesis, selective, X-linked 1,"
F8	2157	hgsc.bcm.edu	36	X	153838448	153838448	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-24-1548-01A-01W-0615-10	TCGA-24-1548-10A-01W-0615-10	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	X	153838448	153838448	G	T	SNP	F8	NM_000132	human	genbank	54_36p	-1	reviewed	missense	c.1730	p.S577Y	1	superfamily_Cupredoxins	"superfamily_Cupredoxins,HMMPfam_Cu-oxidase_3,HMMPfam_Cu-oxidase,PatternScan_MULTICOPPER_OXIDASE1,HMMPfam_Cu-oxidase_2,HMMSmart_SM00231,superfamily_Galactose-binding domain-like,HMMPfam_F5_F8_type_C,PatternScan_FA58C_1,PatternScan_FA58C_2"	-	no_errors	F8	306700.0148	577	S	P	Hemophilia A
IQSEC2	23096	hgsc.bcm.edu	36	X	53287693	53287693	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0761-01A-01W-0370-10	TCGA-13-0761-10A-01W-0370-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	X	53287693	53287693	C	A	SNP	IQSEC2	NM_015075	human	genbank	54_36p	-1	validated	missense	c.2398	p.V800L	1	"superfamily_SSF50729,HMMSmart_PH"	"superfamily_Sec7,HMMPfam_Sec7,HMMSmart_Sec7,superfamily_SSF50729,HMMSmart_PH"	-	no_errors	IQSEC2	300522.0002	801	Q	P	"Mental retardation, X-linked 1,"
CNGA3	1261	hgsc.bcm.edu	36	2	98379650	98379650	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0714-01A-01W-0370-10	TCGA-13-0714-10B-01W-0370-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	2	98379650	98379650	G	A	SNP	CNGA3	NM_001298	human	genbank	54_36p	1	reviewed	missense	c.1585	p.V529M	1	"HMMPfam_cNMP_binding,HMMSmart_cNMP,superfamily_cNMP_binding"	"HMMPfam_cNMP_binding,HMMSmart_cNMP,HMMPfam_Ion_trans,PatternScan_CNMP_BINDING_1,PatternScan_CNMP_BINDING_2,superfamily_cNMP_binding,superfamily_SSF81324"	-	no_errors	CNGA3	600053.0008	529	V	M	"Achromatopsia-2,"
EFEMP1	2202	hgsc.bcm.edu	36	2	55951730	55951730	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-1614-01A-01W-0552-10	TCGA-24-1614-10A-01W-0552-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	2	55951730	55951730	G	A	SNP	EFEMP1	NM_001039348	human	genbank	54_36p	-1	reviewed	missense	c.1033	p.R345W	1	"superfamily_EGF/Laminin,PatternScan_EGF_CA,HMMPfam_EGF_CA,HMMSmart_SM00179,HMMSmart_SM00181"	"superfamily_EGF/Laminin,PatternScan_EGF_CA,HMMPfam_EGF_CA,HMMSmart_SM00179,HMMSmart_SM00181,PatternScan_ASX_HYDROXYL,PatternScan_EGF_2"	-	no_errors	EFEMP1	601548.0001	345	R	W	"Doyne honeycomb degeneration of retina,"
LRP2	4036	hgsc.bcm.edu	36	2	169770382	169770382	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-36-1577-01A-01W-0615-10	TCGA-36-1577-10A-01W-0615-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	2	169770382	169770382	C	G	SNP	LRP2	NM_004525	human	genbank	54_36p	-1	validated	missense	c.7568	p.W2523S	1	"superfamily_SSF63825,HMMSmart_LY,HMMPfam_Ldl_recept_b"	###############################################################################################################################################################################################################################################################	-	no_errors	LRP2	600073.0001	2522	Y	H	"Donnai-Barrow syndrome,"
F2	2147	hgsc.bcm.edu	36	11	46697948	46697948	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-24-1544-01A-01W-0615-10	TCGA-24-1544-10A-01W-0615-10	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	11	46697948	46697948	A	T	SNP	F2	NM_000506	human	genbank	54_36p	1	reviewed	missense	c.200	p.Y67F	0.98	"HMMSmart_GLA,superfamily_VitK_dep_GLA,HMMPfam_Gla,PatternScan_GLA_1"	###############################################################################################################################################################################################################################################################	-	no_errors	F2	176930.0012	67	R	H	Hypoprothrombinemia; Dysprothrombinemia; Hyperprothrombinemia
MEN1	4221	hgsc.bcm.edu	36	11	64329795	64329795	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-10-0927-01A-02W-0419-10	TCGA-10-0927-11A-01W-0419-10	T	T	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	11	64329795	64329795	T	C	SNP	MEN1	NM_000244	human	genbank	54_36p	-1	reviewed	missense	c.1088	p.E363G	1	HMMPfam_Menin	HMMPfam_Menin	-	no_errors	MEN1	131100.0009	363	E	-	"Multiple endocrine neoplasia I; Hyperparathyroidism, AD; Prolactinoma, hyperparathyroidism, carcinoid syndrome; Carcinoid tumor of lung; Parathyroid adenoma, somatic; Lipoma, somatic; Angiofibroma, somatic; Adrenal adenoma, somatic"
HNF1A	6927	hgsc.bcm.edu	36	12	119921766	119921766	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-36-1569-01A-01W-0615-10	TCGA-36-1569-10A-01W-0615-10	G	G	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	12	119921766	119921766	G	A	SNP	HNF1A	NM_000545	human	genbank	54_36p	1	reviewed	missense	c.1721	p.S574N	0.09	HMMPfam_HNF-1A_C	"superfamily_Dimerization cofactor of HNF-1 alpha,HMMPfam_HNF-1_N,superfamily_lambda repressor-like DNA-binding domains,superfamily_Homeodomain-like,HMMSmart_SM00389,HMMPfam_Homeobox,PatternScan_HOMEOBOX_1,HMMPfam_HNF-1B_C,HMMPfam_HNF-1A_C"	-	no_errors	HNF1A	142410.0013	574	G	S	"MODY, type III; Diabetes mellitus, noninsulin-dependent, 2; Diabetes mellitus, insulin-dependent; Hepatic adenoma; Renal cell carcinoma; Diabetes mellitus, insulin-dependent, 20,"
KCNA1	3736	hgsc.bcm.edu	36	12	4891330	4891330	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0919-01A-01W-0419-10	TCGA-13-0919-10A-01W-0419-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	12	4891330	4891330	G	A	SNP	KCNA1	NM_000217	human	genbank	54_36p	1	reviewed	missense	c.525	p.M175I	1	superfamily_SSF81324	"superfamily_BTB/POZ_fold,HMMSmart_BTB,HMMPfam_K_tetra,superfamily_SSF81324,HMMPfam_Ion_trans"	-	no_errors	KCNA1	176260.0003	174	V	F	"Episodic ataxia/myokymia syndrome,"
TRPV4	59341	hgsc.bcm.edu	36	12	108706569	108706569	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1555-01A-01W-0552-10	TCGA-24-1555-10A-01W-0552-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	12	108706569	108706569	T	C	SNP	TRPV4	NM_021625	human	genbank	54_36p	-1	reviewed	missense	c.2393	p.D798G	1	NULL	"superfamily_Ankyrin repeat,HMMSmart_SM00248,HMMPfam_Ank,HMMPfam_Ion_trans"	-	no_errors	TRPV4	605427.0007	799	P	L	"Brachyolmia type 3; Spondylometaphyseal dysplasia, Kozlowski type; Metatropic dysplasia; Hereditary motor and sensory neuropathy, type IIc; Scapuloperoneal spinal muscular atrophy,"
ANG	283	hgsc.bcm.edu	36	14	20231685	20231685	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-25-1625-01A-01W-0615-10	TCGA-25-1625-10A-01W-0615-10	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	14	20231685	20231685	A	T	SNP	ANG	NM_001097577	human	genbank	54_36p	1	reviewed	missense	c.122	p.K41I	0.53	"superfamily_RNase A-like,HMMSmart_SM00092,HMMPfam_RnaseA"	"superfamily_RNase A-like,HMMSmart_SM00092,HMMPfam_RnaseA,PatternScan_RNASE_PANCREATIC"	-	no_errors	ANG	105850.0006	40	K	I	"Amyotrophic lateral sclerosis 9,"
CREBBP	1387	hgsc.bcm.edu	36	16	3729725	3729725	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-04-1338-01A-01W-0484-10	TCGA-04-1338-11A-01W-0485-10	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	16	3729725	3729725	A	C	SNP	CREBBP	NM_004380	human	genbank	54_36p	-1	reviewed	missense	c.4135	p.F1379V	1	HMMPfam_DUF906	###############################################################################################################################################################################################################################################################	-	no_errors	CREBBP	600140.0003	1378	R	P	"Rubenstein-Taybi syndrome,"
CRLF1	9244	hgsc.bcm.edu	36	19	18568727	18568728	+	Frame_Shift_Del	DEL	CG	CG	-	novel	Unknown	TCGA-23-1120-01A-02W-0484-10	TCGA-23-1120-10A-01W-0484-10	CG	CG	.	.	.	.	Unknown	Unknown	Somatic	Phase_IV	Capture				SOLID	19	18568727	18568728	CG	-	DEL	CRLF1	NM_004750	human	genbank	54_36p	-1	validated	frame_shift_del	c.830_829	p.R277fs	0.992:0.998	"superfamily_FN_III-like,HMMPfam_fn3,HMMSmart_FN3"	"superfamily_FN_III-like,HMMPfam_EpoR_lig-bind,HMMSmart_FN3,HMMPfam_fn3"	"(deletion:cds_exon[18568702,18568859])"	no_errors	CRLF1	604237.0009	277	R	*	"Cold-induced sweating syndrome; Crisponi syndrome,"
GSS	2937	hgsc.bcm.edu	36	20	32988441	32988441	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-24-1556-01A-01W-0615-10	TCGA-24-1556-10A-01W-0615-10	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	20	32988441	32988441	C	G	SNP	GSS	NM_000178	human	genbank	54_36p	-1	reviewed	missense	c.655	p.D219H	1	"superfamily_SSF56059,HMMPfam_GSH_synth_ATP,HMMPfam_GSH_synthase,superfamily_PreATP-grasp-like"	"superfamily_SSF56059,HMMPfam_GSH_synth_ATP,HMMPfam_GSH_synthase,superfamily_PreATP-grasp-like"	-	no_errors	GSS	601002.0007	219	D	G	"Hemolytic anemia due to glutathione synthetase deficiency; Glutathione synthetase deficiency,"
NRAS	4893	broad.mit.edu	36	1	115058052	115058052	+	Missense_Mutation	SNP	T	T	C	rs11554290	by-hapmap	TCGA-61-2016-01A-01W-0722-08	TCGA-61-2016-10A-01W-0722-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	1	115058052	115058052	T	C	SNP	NRAS	NM_002524	human	genbank	54_36p	-1	reviewed	missense	c.182	p.Q61R	1	"HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases"	"HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases"	-	no_errors	NRAS	164790.0005	60	G	E	"Colorectal cancer; Thyroid carcinoma, follicular; Autoimmune lymphoproliferative syndrome type IV; Noonan syndrome 6,"
NRAS	4893	broad.mit.edu	36	1	115058052	115058052	+	Missense_Mutation	SNP	T	T	C	rs11554290	by-hapmap	TCGA-61-2095-01A-01W-0722-08	TCGA-61-2095-11A-01W-0723-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	1	115058052	115058052	T	C	SNP	NRAS	NM_002524	human	genbank	54_36p	-1	reviewed	missense	c.182	p.Q61R	1	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174"	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174"	-	no_errors	NRAS	164790.0005	60	G	E	"Colorectal cancer; Thyroid carcinoma, follicular; Autoimmune lymphoproliferative syndrome type IV; Noonan syndrome 6,"
PVRL4	81607	broad.mit.edu	36	1	159314045	159314045	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-61-2002-01A-01W-0722-08	TCGA-61-2002-11A-01W-0722-08	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	1	159314045	159314045	G	T	SNP	PVRL4	NM_030916	human	genbank	54_36p	-1	validated	missense	c.552	p.D184E	1	"superfamily_SSF48726,HMMPfam_C2-set_2"	"HMMPfam_V-set,superfamily_SSF48726,HMMSmart_IG,HMMPfam_C2-set_2,HMMSmart_IGc2,HMMPfam_ig"	-	no_errors	PVRL4	609607.0002	185	T	M	"Ectodermal dysplasia-syndactyly syndrome 1,"
LHCGR	3973	broad.mit.edu	36	2	48768695	48768695	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-09-2050-01A-01W-0799-08	TCGA-09-2050-10A-01W-0799-08	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	2	48768695	48768695	A	G	SNP	LHCGR	NM_000233	human	genbank	54_36p	-1	reviewed	missense	c.1745	p.M582T	1	"superfamily_Family A G protein-coupled receptor-like,HMMPfam_7tm_1"	"superfamily_L domain-like,superfamily_Family A G protein-coupled receptor-like,HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1"	-	no_errors	LHCGR	152790.0003	582	D	G	"Precocious puberty, male; Leydig cell hypoplasia with pseudohermaphroditism; Leydig cell hypoplasia with hypergonadotropic hypogonadism; Luteinizing hormone resistance, female; Leydig cell adenoma, somatic, with precocious puberty,"
TLL1	7092	broad.mit.edu	36	4	167144075	167144075	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-61-2113-01A-01W-0722-08	TCGA-61-2113-11A-01W-0723-08	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	4	167144075	167144075	G	T	SNP	TLL1	NM_012464	human	genbank	54_36p	1	reviewed	missense	c.715	p.V239F	1	"superfamily_Metalloproteases (zincins) catalytic domain,HMMSmart_SM00235,HMMPfam_Astacin"	###############################################################################################################################################################################################################################################################	-	no_errors	TLL1	606742.0002	238	V	A	"Atrial septal defect 6,"
DMGDH	29958	broad.mit.edu	36	5	78395229	78395229	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-2060-01A-01W-0799-08	TCGA-13-2060-10A-01W-0799-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	5	78395229	78395229	T	C	SNP	DMGDH	NM_013391	human	genbank	54_36p	-1	reviewed	missense	c.239	p.E80G	1	"HMMPfam_DAO,superfamily_FAD/NAD(P)-binding domain"	"HMMPfam_DAO,HMMPfam_GCV_T,HMMPfam_GCV_T_C,superfamily_Aminomethyltransferase beta-barrel domain,superfamily_Aminomethyltransferase folate-binding domain,superfamily_FAD/NAD(P)-binding domain,superfamily_FAD-linked reductases C-terminal domain"	-	no_errors	DMGDH	605849.0001	81	H	R	"Dimethylglycine dehydrogenase deficiency,"
NR3C1	2908	broad.mit.edu	36	5	142641666	142641666	+	Missense_Mutation	SNP	A	A	G	novel	Unknown	TCGA-59-2348-01A-01W-0799-08	TCGA-59-2348-11A-01W-0800-08	A	A	G	G	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	5	142641666	142641666	A	G	SNP	NR3C1	NM_001024094	human	genbank	54_36p	-1	reviewed	missense	c.2318	p.L773P	1	superfamily_Str_ncl_receptor	"HMMPfam_GCR,HMMSmart_ZnF_C4,superfamily_SSF57716,HMMPfam_zf-C4,PatternScan_NUCLEAR_REC_DBD_1,superfamily_Str_ncl_receptor,HMMSmart_HOLI,HMMPfam_Hormone_recep"	-	no_errors	NR3C1	138040.0012	773	L	P	Cortisol resistance
GLRA1	2741	broad.mit.edu	36	5	151214884	151214884	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-2049-01D-01W-0799-08	TCGA-09-2049-10A-01W-0799-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	5	151214884	151214884	C	A	SNP	GLRA1	NM_000171	human	genbank	54_36p	-1	reviewed	missense	c.607	p.A203S	1	"superfamily_Nicotinic receptor ligand binding domain-like,HMMPfam_Neur_chan_LBD"	"superfamily_Nicotinic receptor ligand binding domain-like,HMMPfam_Neur_chan_LBD,PatternScan_NEUROTR_ION_CHANNEL,superfamily_Neurotransmitter-gated ion-channel transmembrane pore,HMMPfam_Neur_chan_memb"	-	no_errors	GLRA1	138491.0010	202	Y	*	"Startle disease/hyperekplexia, autosomal dominant; Startle disease, autosomal recessive; Hyperekplexia and spastic paraparesis"
PRPH2	5961	broad.mit.edu	36	6	42797500	42797500	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-20-0990-01A-01W	TCGA-20-0990-10A-01W	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	6	42797500	42797500	T	C	SNP	PRPH2	NM_000322	human	genbank	54_36p	-1	reviewed	missense	c.551	p.Y184C	1	"HMMPfam_Tetraspannin,superfamily_Tetraspanin"	"HMMPfam_Tetraspannin,superfamily_Tetraspanin,PatternScan_RDS_ROM1"	-	no_errors	PRPH2	179605.0004	185	L	P	###############################################################################################################################################################################################################################################################
BRAF	673	broad.mit.edu	36	7	140099662	140099662	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1565-01A-01W	TCGA-24-1565-10A-01W	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	7	140099662	140099662	T	C	SNP	BRAF	NM_004333	human	genbank	54_36p	-1	reviewed	missense	c.1742	p.N581S	1	"superfamily_Protein kinase-like (PK-like),HMMSmart_SM00219,HMMPfam_Pkinase,HMMSmart_SM00220,PatternScan_PROTEIN_KINASE_ST"	###############################################################################################################################################################################################################################################################	-	no_errors	BRAF	164757.0019	581	N	D	"Melanoma, malignant, somatic; Colorectal cancer, somatic; Adenocarcinoma of lung, somatic; Nonsmall cell lung cancer, somatic; Cardiofaciocutaneous syndrome,"
TRPS1	7227	broad.mit.edu	36	8	116499853	116499853	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-59-2363-01A-01W-0799-08	TCGA-59-2363-10A-01W-0800-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	8	116499853	116499853	G	A	SNP	TRPS1	NM_014112	human	genbank	54_36p	-1	reviewed	missense	c.2704	p.R902C	1	superfamily_SSF57716	"HMMSmart_ZnF_C2H2,superfamily_SSF57716,HMMSmart_ZnF_GATA,PatternScan_GATA_ZN_FINGER_1,HMMPfam_GATA,PatternScan_ZINC_FINGER_C2H2_1,HMMPfam_zf-C2H2"	-	no_errors	TRPS1	604386.0007	901	T	P	"Trichorhinophalangeal syndrome, type I; Trichorhinophalangeal syndrome, type III,"
TG	7038	broad.mit.edu	36	8	134004768	134004768	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-61-2113-01A-01W-0722-08	TCGA-61-2113-11A-01W-0723-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	8	134004768	134004768	T	C	SNP	TG	NM_003235	human	genbank	54_36p	1	validated	missense	c.4532	p.V1511A	1	superfamily_Thyroglobulin type-1 domain	"HMMPfam_Thyroglobulin_1,HMMSmart_SM00211,PatternScan_THYROGLOBULIN_1_1,superfamily_Thyroglobulin type-1 domain,HMMPfam_COesterase,HMMPfam_GCC2_GCC3,PatternScan_CARBOXYLESTERASE_B_2,superfamily_alpha/beta-Hydrolases,superfamily_TNF receptor-like"	-	no_errors	TG	188450.0003	1511	R	*	"Thyroid dyshormonogenesis 3; Autoimmune thyroid disease, susceptibility to 3,"
TG	7038	broad.mit.edu	36	8	134103548	134103548	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-09-2051-01A-01W-0799-08	TCGA-09-2051-10A-01W-0799-08	G	G					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	8	134103548	134103548	G	A	SNP	TG	NM_003235	human	genbank	54_36p	1	validated	missense	c.7007	p.R2336Q	1	"HMMPfam_COesterase,superfamily_alpha/beta-Hydrolases"	"HMMPfam_Thyroglobulin_1,HMMSmart_SM00211,PatternScan_THYROGLOBULIN_1_1,superfamily_Thyroglobulin type-1 domain,HMMPfam_COesterase,HMMPfam_GCC2_GCC3,PatternScan_CARBOXYLESTERASE_B_2,superfamily_alpha/beta-Hydrolases,superfamily_TNF receptor-like"	-	no_errors	TG	188450.0017	2336	R	Q	"Thyroid dyshormonogenesis 3; Autoimmune thyroid disease, susceptibility to 3,"
CYP11B1	1584	broad.mit.edu	36	8	143953509	143953509	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-59-2355-01A-01W-0799-08	TCGA-59-2355-10A-01W-0800-08	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	8	143953509	143953509	G	C	SNP	CYP11B1	NM_000497	human	genbank	54_36p	-1	reviewed	missense	c.1264	p.R422G	0.98	"HMMPfam_p450,superfamily_Cytochrome_P450"	"HMMPfam_p450,superfamily_Cytochrome_P450,PatternScan_CYTOCHROME_P450"	-	no_errors	CYP11B1	610613.0015	423	Y	*	"Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency; Aldosteronism, glucocorticoid-remediable,"
CYP11B1	1584	broad.mit.edu	36	8	143954132	143954132	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-23-1122-01A-01W	TCGA-23-1122-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	8	143954132	143954132	C	A	SNP	CYP11B1	NM_000497	human	genbank	54_36p	-1	reviewed	missense	c.1119	p.L373F	1	"HMMPfam_p450,superfamily_Cytochrome_P450"	"HMMPfam_p450,superfamily_Cytochrome_P450,PatternScan_CYTOCHROME_P450"	-	no_errors	CYP11B1	610613.0004	374	R	Q	"Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency; Aldosteronism, glucocorticoid-remediable,"
SURF1	6834	broad.mit.edu	36	9	135208748	135208748	+	Nonsense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-23-2078-01A-01W-0722-08	TCGA-23-2078-10A-01W-0722-08	G	G					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	9	135208748	135208748	G	T	SNP	SURF1	NM_003172	human	genbank	54_36p	-1	reviewed	nonsense	c.822	p.Y274*	1	HMMPfam_SURF1	HMMPfam_SURF1	-	no_errors	SURF1	185620.0010	274	Y	D	"Leigh syndrome, due to COX deficiency,"
OPTN	10133	broad.mit.edu	36	10	13207996	13207996	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-30-1853-01A-02W-0699-08	TCGA-30-1853-10A-01W-0699-08	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	10	13207996	13207996	A	C	SNP	OPTN	NM_001008211	human	genbank	54_36p	1	reviewed	missense	c.1193	p.Q398P	0.99	NULL	NULL	-	no_errors	OPTN	602432.0006	398	Q	*	"Glaucoma 1, open angle, E; Glaucoma, normal tension, susceptibility to; Amytrophic lateral sclerosis 12,"
PTEN	5728	broad.mit.edu	36	10	89707652	89707652	+	Frame_Shift_Del	DEL	C	-	-	novel	Unknown	TCGA-13-1492-01A-01D	TCGA-13-1492-10A-01W	C	C	-	-	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	10	89707652	89707652	C	-	DEL	PTEN	NM_000314	human	genbank	54_36p	1	reviewed	frame_shift_del	c.697	p.R233fs	1	"HMMPfam_PTEN_C2,superfamily_C2 domain (Calcium/lipid-binding domain CaLB)"	"superfamily_(Phosphotyrosine protein) phosphatases II,HMMSmart_SM00404,PatternScan_TYR_PHOSPHATASE_1,HMMPfam_DSPc,HMMPfam_PTEN_C2,superfamily_C2 domain (Calcium/lipid-binding domain CaLB)"	"(deletion:cds_exon[89707590,89707756])"	no_errors	PTEN	601728.0002	233	R	*	###############################################################################################################################################################################################################################################################
ABCC8	6833	broad.mit.edu	36	11	17375098	17375098	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-2392-01A-01W-0799-08	TCGA-25-2392-10A-01W-0799-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	11	17375098	17375098	C	A	SNP	ABCC8	NM_000352	human	genbank	54_36p	-1	reviewed	missense	c.4060	p.D1354Y	1	superfamily_P-loop containing nucleoside triphosphate hydrolases	"superfamily_Multidrug resistance ABC transporter MsbA N-terminal domain,HMMPfam_ABC_membrane,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00382,HMMPfam_ABC_tran,PatternScan_ABC_TRANSPORTER_1"	-	no_errors	ABCC8	600509.0012	1353	R	H	"Hyperinsulinemic hypoglycemia, familial, 1; Hypoglycemia of infancy, leucine-sensitive; Diabetes mellitus, transient neonatal 2; Diabetes mellitus, noninsulin-dependent; Diabetes mellitus, permanent neonatal,"
MYO7A	4647	broad.mit.edu	36	11	76547025	76547025	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-1496-01A-01W	TCGA-13-1496-10A-01W	C	C					Unknown	Unknown	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	11	76547025	76547025	C	T	SNP	MYO7A	NM_000260	human	genbank	54_36p	1	reviewed	missense	c.904	p.R302C	1	"HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases"	###############################################################################################################################################################################################################################################################	-	no_errors	MYO7A	276903.0006	302	R	H	"Usher syndrome, type 1B; Deafness, autosomal recessive 2, neurosensory; Deafness, autosomal dominant 11, neurosensory,"
TRPC6	7225	broad.mit.edu	36	11	100880101	100880101	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-61-2111-01A-01W-0722-08	TCGA-61-2111-11A-01W-0723-08	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	11	100880101	100880101	G	T	SNP	TRPC6	NM_004621	human	genbank	54_36p	-1	reviewed	missense	c.809	p.S270Y	1	HMMPfam_TRP_2	"HMMPfam_Ank,HMMSmart_SM00248,superfamily_Ankyrin repeat,HMMPfam_Ion_trans,HMMPfam_TRP_2"	-	no_errors	TRPC6	603652.0003	270	S	T	"Glomerulosclerosis, focal segmental, 2,"
HMBS	3145	broad.mit.edu	36	11	118464151	118464177	+	Splice_Site	DEL	GTGACCTGGGGACTTTTTCTGCAGGAA	-	GTGACCTGGGGACTTTTTCTGCAGGAA	novel	Unknown	TCGA-09-2044-01B-01W-0799-08	TCGA-09-2044-10A-01W-0799-08	GTGACCTGGGGACTTTTTCTGCAGGAA	GTGACCTGGGGACTTTTTCTGCAGGAA					Unknown	Unknown	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	11	118464151	118464177	GTGACCTGGGGACTTTTTCTGCAGGAA	-	DEL	HMBS	NM_000190	human	genbank	54_36p	1	reviewed	splice_site_del	c.34-24_34-1	e2-1	0.026:0.010:0.002:0.002:0.000:0.000:0.000:0.007:0.010:0.013:0.002:0.009:0.029:0.050:0.050:0.056:0.042:0.041:0.017:0.033:0.727:0.986:1.000:1.000:1.000:0.998:0.967	-	-	"(deletion:intron[118460987,118464174], cds_exon[118464175,118464228])"	no_errors	HMBS	609806.0004	116	R	W	"Porphyria, acute intermittent; Porphyria, acute intermittent, nonerythroid variant,"
TECTA	7007	broad.mit.edu	36	11	120536216	120536216	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-24-0979-01A-01W	TCGA-24-0979-10B-01W	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	11	120536216	120536216	G	T	SNP	TECTA	NM_005422	human	genbank	54_36p	1	reviewed	missense	c.4852	p.V1618L	1	"HMMPfam_VWD,HMMSmart_SM00216"	###############################################################################################################################################################################################################################################################	-	no_errors	TECTA	602574.0005	1619	C	S	"Deafness, autosomal dominant 8/12; Deafness, autosomal recessive 21,"
KIRREL3	84623	broad.mit.edu	36	11	125821979	125821979	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-04-1367-01A-01W	TCGA-04-1367-10A-01W	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	11	125821979	125821979	A	T	SNP	KIRREL3	NM_032531	human	genbank	54_36p	-1	provisional	missense	c.1010	p.M337K	1	"HMMPfam_I-set,superfamily_Immunoglobulin"	"HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set,HMMPfam_V-set,HMMPfam_C2-set_2,superfamily_Immunoglobulin"	-	no_errors	KIRREL3	607761.0002	336	R	Q	"Mental retardation, autosomal dominant 4,"
KCNJ1	3758	broad.mit.edu	36	11	128214814	128214814	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-31-1950-01A-01W-0699-08	TCGA-31-1950-10A-01W-0699-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	11	128214814	128214814	C	T	SNP	KCNJ1	NM_000220	human	genbank	54_36p	-1	reviewed	missense	c.592	p.A198T	0.99	"HMMPfam_IRK,superfamily_E set domains"	"superfamily_Voltage-gated potassium channels,HMMPfam_IRK,superfamily_E set domains"	-	no_errors	KCNJ1	600359.0007	198	A	T	"Bartter syndrome, type 2,"
KRAS	3845	broad.mit.edu	36	12	25289551	25289551	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-2038-01A-01W-0722-08	TCGA-24-2038-10A-01W-0722-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	12	25289551	25289551	C	A	SNP	KRAS	NM_033360	human	genbank	54_36p	-1	reviewed	missense	c.35	p.G12V	1	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	"HMMSmart_SM00173,superfamily_P-loop containing nucleoside triphosphate hydrolases,HMMSmart_SM00175,HMMPfam_Ras,HMMSmart_SM00174,HMMSmart_SM00176"	-	no_errors	KRAS	190070.0008	11	G	-	"Lung cancer; Bladder cancer; Breast cancer, somatic; Pancreatic carcinoma, somatic; Stomach cancer; Leukemia, acute myelogenous; Noonan syndrome 3; Cardiofaciocutaneous syndrome,"
FGD4	121512	broad.mit.edu	36	12	32642767	32642767	+	Nonsense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-25-2393-01A-01W-0799-08	TCGA-25-2393-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	12	32642767	32642767	C	T	SNP	FGD4	NM_139241	human	genbank	54_36p	1	reviewed	nonsense	c.670	p.R224*	1	"superfamily_DBL homology domain (DH-domain),HMMPfam_RhoGEF,HMMSmart_SM00325"	"superfamily_DBL homology domain (DH-domain),HMMPfam_RhoGEF,HMMSmart_SM00325,superfamily_PH domain-like,HMMPfam_PH,HMMSmart_SM00233,HMMSmart_SM00064,HMMPfam_FYVE,superfamily_FYVE/PHD zinc finger"	-	no_errors	FGD4	611104.0001	224	R	*	"Charcot-Marie-Tooth disease, type 4H,"
VDR	7421	broad.mit.edu	36	12	46537571	46537571	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-2288-01A-01W-0799-08	TCGA-24-2288-10A-01W-0799-08	C	C					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	12	46537571	46537571	C	A	SNP	VDR	NM_000376	human	genbank	54_36p	-1	reviewed	missense	c.445	p.D149Y	0.98	superfamily_Nuclear receptor ligand-binding domain	"HMMSmart_SM00399,HMMPfam_zf-C4,superfamily_Glucocorticoid receptor-like (DNA-binding domain),PatternScan_NUCLEAR_REC_DBD_1,superfamily_Nuclear receptor ligand-binding domain,HMMSmart_SM00430,HMMPfam_Hormone_recep"	-	no_errors	VDR	601769.0006	149	Q	*	"Rickets, vitamin D-resistant, type IIA; ?Osteoporosis, involutional,"
PAH	5053	broad.mit.edu	36	12	101770838	101770838	+	Nonsense_Mutation	SNP	G	G	A	rs5030846	Unknown	TCGA-59-2354-01A-01W-0799-08	TCGA-59-2354-11A-01W-0800-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	12	101770838	101770838	G	A	SNP	PAH	NM_000277	human	genbank	54_36p	-1	reviewed	nonsense	c.727	p.R243*	1	"HMMPfam_Biopterin_H,superfamily_Aaa_hydroxylase"	"HMMPfam_ACT,PatternScan_BIOPTERIN_HYDROXYL,HMMPfam_Biopterin_H,superfamily_Aaa_hydroxylase,superfamily_SSF55021"	-	no_errors	PAH	612349.0014	243	R	Q	"Phenylketonuria; Hyperphenylalaninemia, non-PKU mild,"
BRCA2	675	broad.mit.edu	36	13	31812137	31812137	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-2050-01A-01W-0799-08	TCGA-09-2050-10A-01W-0799-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	13	31812137	31812137	C	A	SNP	BRCA2	NM_000059	human	genbank	54_36p	1	reviewed	nonsense	c.5645	p.S1882*	0.01	NULL	"HMMPfam_BRCA2,HMMPfam_BRCA-2_OB1,HMMPfam_BRCA-2_OB3,HMMPfam_Tower,HMMPfam_BRCA-2_helical,superfamily_BRCA2_helical,superfamily_Nucleic_acid_OB,superfamily_SSF81878"	-	no_errors	BRCA2	600185.0031	1882	S	*	"Breast-ovarian cancer, familial, 2; Fanconi anemia, complementation group D1; Prostate cancer; Breast cancer, male, susceptibility to; Wilms tumor; Medulloblastoma; Glioblastoma 3; Pre-B-cell acute lymphoblastic leukemia; Pancreatic cancer,"
OCA2	4948	broad.mit.edu	36	15	25902144	25902144	+	Missense_Mutation	SNP	G	G	C	novel	Unknown	TCGA-25-2398-01A-01W-0799-08	TCGA-25-2398-10A-01W-0799-08	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	15	25902144	25902144	G	C	SNP	OCA2	NM_000275	human	genbank	54_36p	-1	reviewed	missense	c.1445	p.T482S	1	HMMPfam_CitMHS	HMMPfam_CitMHS	-	no_errors	OCA2	611409.0003	481	A	T	"Albinism, oculocutaneous, type II; Albinism, brown oculocutaneous; Skin/hair/eye pigmentation 1, blue/nonblue eyes; Skin/hair/eye pigmentation 1, blond/brown hair,"
CDAN1	146059	broad.mit.edu	36	15	40805047	40805047	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-59-2351-01A-01W-0799-08	TCGA-59-2351-10A-01W-0800-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	15	40805047	40805047	G	A	SNP	CDAN1	NM_138477	human	genbank	54_36p	-1	validated	missense	c.3382	p.P1128S	1	NULL	NULL	-	no_errors	CDAN1	607465.0002	1129	P	L	"Anemia, congenital dyserythropoietic, type I,"
IL4R	3566	broad.mit.edu	36	16	27281903	27281903	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0913-01A-01W	TCGA-13-0913-10A-01D	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	16	27281903	27281903	G	A	SNP	IL4R	NM_000418	human	genbank	54_36p	1	reviewed	missense	c.1729	p.E577K	0.18	NULL	"superfamily_Fibronectin type III,HMMPfam_IL4Ra_N,PatternScan_HEMATOPO_REC_S_F1"	-	no_errors	IL4R	147781.0001	576	Q	R	"Atopy, susceptibility to; AIDS, slow progression to,"
ATP8B1	5205	broad.mit.edu	36	18	53506591	53506591	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-61-2111-01A-01W-0722-08	TCGA-61-2111-11A-01W-0723-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	18	53506591	53506591	G	A	SNP	ATP8B1	NM_005603	human	genbank	54_36p	-1	reviewed	missense	c.1367	p.T456M	1	"PatternScan_ATPASE_E1_E2,superfamily_SSF56784,superfamily_SSF81665"	"HMMPfam_E1-E2_ATPase,PatternScan_ATPASE_E1_E2,superfamily_SSF56784,superfamily_SSF81653,superfamily_SSF81660,superfamily_SSF81665"	-	no_errors	ATP8B1	602397.0012	456	T	M	"Cholestasis, progressive familial intrahepatic 1; Cholestasis, benign recurrent intrahepatic,"
PROKR2	128674	broad.mit.edu	36	20	5242763	5242763	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-1313-01A-01W	TCGA-25-1313-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	20	5242763	5242763	G	A	SNP	PROKR2	NM_144773	human	genbank	54_36p	-1	reviewed	missense	c.253	p.R85C	1	"HMMPfam_7tm_1,superfamily_SSF81321"	"HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1,superfamily_SSF81321"	-	no_errors	PROKR2	607123.0003	85	R	H	"Kallmann syndrome 3,"
DNMT3B	1789	broad.mit.edu	36	20	30853861	30853861	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-23-2077-01A-01W-0722-08	TCGA-23-2077-10A-01W-0722-08	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	20	30853861	30853861	G	T	SNP	DNMT3B	NM_006892	human	genbank	54_36p	1	reviewed	missense	c.2155	p.V719L	1	"superfamily_S-adenosyl-L-methionine-dependent methyltransferases,HMMPfam_DNA_methylase"	"superfamily_Tudor/PWWP/MBT,HMMPfam_PWWP,HMMSmart_SM00293,superfamily_FYVE/PHD zinc finger,superfamily_S-adenosyl-L-methionine-dependent methyltransferases,HMMPfam_DNA_methylase,PatternScan_C5_MTASE_1"	-	no_errors	DNMT3B	602900.0003	718	V	G	"Immunodeficiency-centromeric instability-facial anomalies syndrome,"
GNAS	2778	broad.mit.edu	36	20	56913889	56913889	+	Nonsense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-13-0913-01A-01W	TCGA-13-0913-10A-01D	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture;Sequenom			Illumina GAIIx	20	56913889	56913889	C	G	SNP	GNAS	NM_001077488	human	genbank	54_36p	1	reviewed	nonsense	c.492	p.Y164*	0.98	"HMMPfam_G-alpha,superfamily_SSF52540,superfamily_Transducn_insert"	"HMMPfam_G-alpha,superfamily_SSF52540,superfamily_Transducn_insert"	-	no_errors	GNAS	139320.0007	165	C	R	"Pseudohypoparathyroidism Ia; McCune-Albright syndrome; Pseudohypoparathyroidism Ic; Osseous heteroplasia, progressive; Pseudohypoparathyroidism Ib; Prolonged bleeding time, brachydactyly and mental retardation; Acromegaly; Pseudopseudohypoparathyroidism,"
COL6A2	1292	broad.mit.edu	36	21	46376631	46376631	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-20-0990-01A-01W	TCGA-20-0990-10A-01W	C	C					Unknown	Unknown	Somatic	Phase_I	Capture	---			Illumina GAIIx	21	46376631	46376631	C	T	SNP	COL6A2	NM_001849	human	genbank	54_36p	1	reviewed	missense	c.2797	p.R933C	0	"HMMPfam_VWA,HMMSmart_SM00327,superfamily_vWA-like"	"HMMPfam_VWA,HMMSmart_SM00327,HMMPfam_Collagen,superfamily_vWA-like"	-	no_errors	COL6A2	120240.0010	932	P	L	"Bethlem myopathy; Ullrich congenital muscular dystrophy; Myosclerosis, congenital,"
BMP15	9210	broad.mit.edu	36	X	50675797	50675797	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-23-1032-01A-02W	TCGA-23-1032-10A-01W	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	X	50675797	50675797	A	T	SNP	BMP15	NM_005448	human	genbank	54_36p	1	reviewed	missense	c.629	p.Q210L	0.42	NULL	"superfamily_SSF57501,HMMPfam_TGF_beta,HMMSmart_TGFB,PatternScan_TGF_BETA_1"	-	no_errors	BMP15	300247.0004	211	E	*	"Ovarian dysgenesis 2; Premature ovarian failure 4,"
PLP1	5354	broad.mit.edu	36	X	102928267	102928267	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-1504-01A-01W	TCGA-13-1504-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom;Capture			Illumina GAIIx	X	102928267	102928267	C	T	SNP	PLP1	NM_000533	human	genbank	54_36p	1	reviewed	missense	c.409	p.R137W	1	HMMPfam_Myelin_PLP	"HMMPfam_Myelin_PLP,PatternScan_MYELIN_PLP_1,HMMSmart_SM00002,PatternScan_MYELIN_PLP_2"	-	no_errors	PLP1	300401.0026	137	R	W	"Pelizaeus-Merzbacher disease; Spastic paraplegia-2,"
TTN	7273	genome.wustl.edu	36	2	179313341	179313341	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0755-01A-01W-0372-09	TCGA-13-0755-10A-01W-0372-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	2	179313341	179313341	C	A	SNP	TTN	ENST00000359218	human	ensembl	54_36p	-1	known	missense	c.12156	p.E4052D	1	NULL	"PatternScan_IG_MHC,HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_fn3,HMMSmart_SM00060,HMMPfam_I-set,HMMPfam_ig,HMMPfam_Titin_Z,PatternScan_FGGY_KINASES_1"	-	no_stop_codon	TTN	188840.0009	4053	Q	*	###############################################################################################################################################################################################################################################################
USH2A	7399	genome.wustl.edu	36	1	214487150	214487150	+	Nonsense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-23-1117-01A-02W-0488-09	TCGA-23-1117-10A-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	1	214487150	214487150	G	A	SNP	USH2A	NM_206933	human	genbank	54_36p	-1	reviewed	nonsense	c.2209	p.R737*	0.83	"HMMPfam_Laminin_EGF,HMMSmart_SM00180,PatternScan_EGF_LAM_1,superfamily_Concanavalin A-like lectins/glucanases,superfamily_EGF/Laminin"	###############################################################################################################################################################################################################################################################	-	no_errors	USH2A	608400.0011	737	R	*	"Usher syndrome, type 2A; Retinitis pigmentosa-39,"
RB1	5925	genome.wustl.edu	36	13	47853541	47853556	+	Frame_Shift_Del	DEL	ATGTGAACATCGAATC	ATGTGAACATCGAATC	-	novel	Unknown	TCGA-24-1463-01A-01W-0549-09	TCGA-24-1463-10A-01W-0549-09	ATGTGAACATCGAATC	ATGTGAACATCGAATC	ATGTGAACATCGAATC	-	ATGTGAACATCGAATC	ATGTGAACATCGAATC	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	13	47853541	47853556	ATGTGAACATCGAATC	-	DEL	RB1	NM_000321	human	genbank	54_36p	1	reviewed	frame_shift_del	c.1656_1671	p.C553fs	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.999:1.000:1.000:1.000	"HMMPfam_RB_A,superfamily_Cyclin-like"	"HMMPfam_RB_A,superfamily_Cyclin-like,HMMPfam_RB_B,HMMSmart_SM00385,HMMPfam_Rb_C"	"(deletion:cds_exon[47853384,47853580])"	no_errors	RB1	180200.0022	556	R	*	Retinoblastoma; Osteosarcoma; Bladder cancer; Pinealoma with bilateral retinoblastoma
RB1	5925	genome.wustl.edu	36	13	47937375	47937375	+	Nonsense_Mutation	SNP	C	T	T	novel	Unknown	TCGA-10-0933-01A-01W-0421-09	TCGA-10-0933-11A-01W-0421-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	13	47937375	47937375	C	T	SNP	RB1	NM_000321	human	genbank	54_36p	1	reviewed	nonsense	c.2359	p.R787*	1	HMMPfam_Rb_C	"HMMPfam_RB_B,HMMPfam_RB_A,HMMSmart_SM00385,superfamily_Cyclin-like,HMMPfam_Rb_C"	-	no_errors	RB1	180200.0005	787	R	*	Retinoblastoma; Osteosarcoma; Bladder cancer; Pinealoma with bilateral retinoblastoma
TP53	7157	genome.wustl.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	A	A	rs28934574	Unknown	TCGA-24-1416-01A-01W-0549-09	TCGA-24-1416-10A-01W-0549-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-13-0726-01A-01W-0372-09	TCGA-13-0726-10B-01W-0977-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517824	7517824	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-1482-01A-01W-0549-09	TCGA-13-1482-10A-01W-0549-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517824	7517824	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.839	p.R280I	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0024	280	R	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517842	7517842	+	Missense_Mutation	SNP	A	A	T	novel	Unknown	TCGA-24-1463-01A-01W-0549-09	TCGA-24-1463-10A-01W-0549-09	A	A	A	T	A	A	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517842	7517842	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.821	p.V274D	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0020	273	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	A	A	rs28934576	Unknown	TCGA-13-0791-01A-01W-0372-09	TCGA-13-0791-10A-01W-0372-09	C	C	A	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273L	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-04-1542-01A-01W-0553-09	TCGA-04-1542-10A-01W-0553-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-13-0804-01A-01W-0372-09	TCGA-13-0804-10A-01W-0372-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-25-1315-01A-01W-0494-09	TCGA-25-1315-10A-01W-0494-09	C	C	T	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-24-1426-01A-01W-0549-09	TCGA-24-1426-10A-01W-0549-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-1499-01A-01W-0549-09	TCGA-13-1499-10A-01W-0549-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	"454_PCR_WGA,Sanger_PCR_WGA"		dbGAP	Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517849	7517849	+	Frame_Shift_Del	DEL	C	C	-	novel	Unknown	TCGA-24-1427-01A-01W-0549-09	TCGA-24-1427-10A-01W-0549-09	C	C	C	-	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517849	7517849	C	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.814	p.V272fs	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7517744,7517880])"	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	Unknown	TCGA-13-1499-01A-01W-0549-09	TCGA-13-1499-10A-01W-0549-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-04-1336-01A-01W-0488-09	TCGA-04-1336-11A-01W-0489-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-0982-01A-01W-0488-09	TCGA-24-0982-10C-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-0966-01A-01W-0977-09	TCGA-24-0966-10A-01W-0421-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518272	7518272	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245V	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0893-01B-01W-0494-09	TCGA-13-0893-10A-01W-0494-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518272	7518272	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245D	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	A	A	rs28934573	Unknown	TCGA-04-1349-01A-01W-0494-09	TCGA-04-1349-11A-01W-0494-09	G	G	A	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0013	241	S	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-1404-01A-01W-0494-09	TCGA-13-1404-10A-01W-0495-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-23-1123-01A-01W-0488-09	TCGA-23-1123-10A-01W-0488-09	C	C	C	T	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	A	A	novel	Unknown	TCGA-13-0724-01A-01W-0372-09	TCGA-13-0724-10B-01W-0372-09	C	C	A	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0007	157	V	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519188	7519188	+	Missense_Mutation	SNP	C	G	G	novel	Unknown	TCGA-23-1124-01A-01W-0488-09	TCGA-23-1124-10A-01W-0488-09	C	C	G	G	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519188	7519188	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.467	p.R156P	0.01	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0007	157	V	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519195	7519225	+	Frame_Shift_Del	DEL	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	-	novel	Unknown	TCGA-23-1117-01A-02W-0488-09	TCGA-23-1117-10A-01W-0488-09	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	-	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519195	7519225	CGGGCGGGGGTGTGGAATCAACCCACAGCTG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.460_430	p.Q144fs	0.496:0.001:0.001:0.001:0.001:0.996:0.998:0.906:0.998:0.997:0.001:0.001:0.001:0.000:0.000:0.000:0.000:0.000:0.000:0.014:0.987:0.994:0.947:0.886:0.843:0.860:0.979:0.970:0.987:0.998:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	191170.0026	151	P	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519204	7519204	+	Missense_Mutation	SNP	G	G	A	rs28934874	Unknown	TCGA-23-1118-01A-01W-0488-09	TCGA-23-1118-10A-01W-0488-09	G	G	G	A	G	G	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519204	7519204	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.451	p.P151S	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0026	151	P	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519259	7519259	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-0366-01A-01W-0372-09	TCGA-09-0366-10B-01W-0372-09	C	C	C	A	C	C	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519259	7519259	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.396	p.K132N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0011	133	M	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519260	7519260	+	Missense_Mutation	SNP	T	A	A	novel	Unknown	TCGA-13-0800-01A-01W-0372-09	TCGA-13-0800-10A-01W-0372-09	T	T	A	A	T	T	Unknown	Valid	Somatic	4	Capture	454_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519260	7519260	T	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.395	p.K132M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0011	133	M	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7514743	7514743	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-36-1571-01A-01W-0615-10	TCGA-36-1571-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7514743	7514743	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.1009	p.R337C	0.47	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"HMMPfam_P53_TAD,HMMPfam_P53,superfamily_p53-like transcription factors,PatternScan_P53,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	-	no_errors	TP53	191170.0035	337	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517818	7517818	+	Missense_Mutation	SNP	C	C	G	novel	Unknown	TCGA-04-1525-01A-01W-0615-10	TCGA-04-1525-10A-01W-0615-10	C	C	C	C	C	C	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517818	7517818	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.845	p.R282P	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517818	7517819	+	Frame_Shift_Ins	INS	-	-	G	novel	Unknown	TCGA-04-1525-01A-01W-0615-10	TCGA-04-1525-10A-01W-0615-10	-	-	-	G	-	-	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517818	7517819	-	G	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.845_844	p.R282fs	0.996:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-10-0937-01A-02W-0419-10	TCGA-10-0937-11A-01W-0419-10	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-24-1567-01A-01W-0615-10	TCGA-24-1567-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517819	7517819	+	Missense_Mutation	SNP	G	G	A	rs28934574	Unknown	TCGA-25-1623-01A-01W-0615-10	TCGA-25-1623-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517819	7517819	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.844	p.R282W	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517821	7517821	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-23-1023-01A-03W-0484-10	TCGA-23-1023-10A-01W-0484-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517821	7517821	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.842	p.D281G	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0024	280	R	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-04-1530-01A-02W-0552-10	TCGA-04-1530-10A-01W-0552-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-13-0761-01A-01W-0370-10	TCGA-13-0761-10A-01W-0370-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-13-0900-01B-01W-0490-10	TCGA-13-0900-10A-01W-0490-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-24-1558-01A-01W-0615-10	TCGA-24-1558-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-36-1575-01A-01W-0615-10	TCGA-36-1575-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-36-1578-01A-01W-0615-10	TCGA-36-1578-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-13-0889-01A-01W-0419-10	TCGA-13-0889-10A-01W-0419-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-36-1580-01A-01W-0615-10	TCGA-36-1580-10A-01W-0615-10	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518231	7518231	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-09-1665-01B-01W-0615-10	TCGA-09-1665-11B-01W-0616-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518231	7518231	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.775	p.D259Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0002	258	E	K	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518231	7518231	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1635-01A-01W-0615-10	TCGA-25-1635-10A-01W-0616-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518231	7518231	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.775	p.D259Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0002	258	E	K	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518257	7518257	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-23-1028-01A-01W-0484-10	TCGA-23-1028-10B-01W-0484-10	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518257	7518257	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.749	p.P250L	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0006	249	R	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	T	T	rs11540652	byHapMap	TCGA-04-1364-01A-01W-0490-10	TCGA-04-1364-10A-01W-0490-10	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518263	7518264	+	Frame_Shift_Ins	INS	-	-	G	novel	Unknown	TCGA-36-1570-01A-01W-0615-10	TCGA-36-1570-10A-01W-0615-10	-	-	-	G	-	-	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518263	7518264	-	G	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.743_742	p.R248fs	1.000:1.000	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	C	C	novel	Unknown	TCGA-25-1632-01A-01W-0615-10	TCGA-25-1632-10A-01W-0615-10	G	G	C	C	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518264	7518264	G	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248G	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1626-01A-01W-0615-10	TCGA-25-1626-10A-01W-0615-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518272	7518272	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245V	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-25-1317-01A-01W-0490-10	TCGA-25-1317-10A-01W-0490-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518273	7518273	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245C	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	T	rs28934575	Unknown	TCGA-04-1338-01A-01W-0484-10	TCGA-04-1338-11A-01W-0485-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518273	7518273	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245S	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	T	rs28934575	Unknown	TCGA-36-1568-01A-01W-0615-10	TCGA-36-1568-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7518273	7518273	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245S	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518276	7518276	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1560-01A-01W-0615-10	TCGA-24-1560-10A-01W-0615-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518276	7518276	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.730	p.G244C	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-24-1545-01A-01W-0615-10	TCGA-24-1545-10A-01W-0615-10	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518284	7518284	G	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241Y	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0013	241	S	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1548-01A-01W-0615-10	TCGA-24-1548-10A-01W-0615-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-24-1553-01A-01W-0552-10	TCGA-24-1553-10A-01W-0552-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-25-1627-01A-01W-0615-10	TCGA-25-1627-10A-01W-0615-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	A	A	novel	Unknown	TCGA-24-1544-01A-01W-0615-10	TCGA-24-1544-10A-01W-0615-10	C	C	C	C	C	C	Unknown	None	Wildtype	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519128	7519128	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176F	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-09-1662-01A-01W-0615-10	TCGA-09-1662-10A-01W-0616-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-57-1584-01A-01W-0615-10	TCGA-57-1584-11A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_III	Capture	454_PCR_WGA			SOLID	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-25-1318-01A-01W-0490-10	TCGA-25-1318-10A-01W-0490-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-25-1633-01A-01W-0615-10	TCGA-25-1633-10A-01W-0616-10	C	C	.	.	.	.	Unknown	Unknown	Somatic	Phase_III	Capture				SOLID	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-13-0919-01A-01W-0419-10	TCGA-13-0919-10A-01W-0419-10	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0007	157	V	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1105-01A-01W-0484-10	TCGA-24-1105-10A-01W-0484-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0007	157	V	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1614-01A-01W-0552-10	TCGA-24-1614-10A-01W-0552-10	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_IV	Capture	454_PCR_WGA			SOLID	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0007	157	V	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519255	7519255	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-13-0906-01A-01W-0419-10	TCGA-13-0906-10A-01W-0419-10	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_IV	Capture	Sanger_PCR_WGA			SOLID	17	7519255	7519255	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.400	p.F134V	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0011	133	M	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7519260	7519260	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-23-1026-01B-01W-0484-10	TCGA-23-1026-10A-01W-0484-10	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_III	Capture	Sanger_PCR_WGA			SOLID	17	7519260	7519260	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.395	p.K132R	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0011	133	M	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7514720	7514720	+	Frame_Shift_Del	DEL	C	C	-	novel	Unknown	TCGA-24-1434-01A-01W	TCGA-24-1434-10A-01W	C	C	-	-	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7514720	7514720	C	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.1032	p.N345fs	0.72	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7514652,7514758])"	no_errors	TP53	191170.0031	344	L	P	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517807	7517807	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-25-1326-01A-01W	TCGA-25-1326-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Broad454,Capture"			Illumina GAIIx	17	7517807	7517807	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.856	p.E286K	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0040	285	E	V	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517813	7517813	+	Frame_Shift_Del	DEL	T	-	T	novel	Unknown	TCGA-24-2267-01A-01W-0799-08	TCGA-24-2267-11A-01W-0799-08	T	T	-	-	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7517813	7517813	T	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.850	p.T284fs	0.04	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7517744,7517880])"	no_errors	TP53	191170.0040	285	E	V	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517827	7517827	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0904-01A-02W	TCGA-13-0904-10A-01D	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517827	7517827	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.836	p.G279E	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0024	280	R	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517842	7517842	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-24-2290-01A-01W-0799-08	TCGA-24-2290-10A-01W-0799-08	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517842	7517842	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.821	p.V274G	0.99	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0020	273	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	A	rs28934576	Unknown	TCGA-13-1512-01A-01W	TCGA-13-1512-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517845	7517845	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273L	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	T	rs28934576	Unknown	TCGA-10-0934-01A-02W	TCGA-10-0934-11A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	C	G	rs28934576	Unknown	TCGA-13-0905-01B-01W	TCGA-13-0905-10A-01W	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517845	7517845	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273P	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-2392-01A-01W-0799-08	TCGA-25-2392-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-59-2348-01A-01W-0799-08	TCGA-59-2348-11A-01W-0800-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517846	7517846	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-1321-01A-01W	TCGA-25-1321-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7517846	7517846	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.817	p.R273C	0.8	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517849	7517849	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-13-0886-01A-01W	TCGA-13-0886-10A-01D	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517849	7517849	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.814	p.V272M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517849	7517849	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-24-2024-01A-02W-0722-08	TCGA-24-2024-11A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517849	7517849	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.814	p.V272M	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7517852	7517852	+	Nonsense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-1471-01A-01W	TCGA-24-1471-10A-01W	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7517852	7517852	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	nonsense	c.811	p.E271*	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518236	7518236	+	Missense_Mutation	SNP	A	A	T	rs28934577	Unknown	TCGA-09-2050-01A-01W-0799-08	TCGA-09-2050-10A-01W-0799-08	A	A	T	T	A	A	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518236	7518236	A	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.770	p.L257Q	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0028	257	L	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518239	7518241	+	In_Frame_Del	DEL	GTG	-	GTG	novel	Unknown	TCGA-23-2078-01A-01W-0722-08	TCGA-23-2078-10A-01W-0722-08	GTG	GTG	-	-	GTG	GTG	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518239	7518241	GTG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.767_765	p.T256in_frame_del	1.000:1.000:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	191170.0028	257	L	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518239	7518247	+	In_Frame_Del	DEL	GTGATGATG	GTGATGATG	-	novel	Unknown	TCGA-23-1031-01A-01W	TCGA-23-1031-10A-01W	GTGATGATG	GTGATGATG	-	-	GTGATGATG	GTGATGATG	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518239	7518247	GTGATGATG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.767_759	p.IIT254in_frame_del	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	191170.0004	252	L	P	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518254	7518254	+	Missense_Mutation	SNP	A	A	C	novel	Unknown	TCGA-13-1504-01A-01W	TCGA-13-1504-10A-01W	A	A	C	C	A	A	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518254	7518254	A	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.752	p.I251S	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0004	252	L	P	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518257	7518257	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-2288-01A-01W-0799-08	TCGA-24-2288-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7518257	7518257	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.749	p.P250L	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0006	249	R	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518261	7518261	+	Missense_Mutation	SNP	T	T	C	rs67185453	Unknown	TCGA-24-1466-01A-01W	TCGA-24-1466-10A-01W	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518261	7518261	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.745	p.R249G	0.99	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-24-0979-01A-01W	TCGA-24-0979-10B-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-24-1419-01A-01W	TCGA-24-1419-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-23-1032-01A-02W	TCGA-23-1032-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-13-1496-01A-01W	TCGA-13-1496-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-10-0934-01A-02W	TCGA-10-0934-11A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"WU-454,Capture"			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-57-1993-01A-01W-0699-08	TCGA-57-1993-11A-01W-0700-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518263	7518263	+	Missense_Mutation	SNP	C	C	T	rs11540652	by-hapmap	TCGA-24-2260-01A-01W-0722-08	TCGA-24-2260-11A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518263	7518263	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.743	p.R248Q	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-25-2409-01A-01W-0799-08	TCGA-25-2409-10A-01W-0799-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-1422-01A-01W	TCGA-24-1422-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	G	A	novel	Unknown	TCGA-24-1551-01A-01W	TCGA-24-1551-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518272	7518272	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-30-1853-01A-02W-0699-08	TCGA-30-1853-10A-01W-0699-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518272	7518272	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.734	p.G245D	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	G	rs28934575	Unknown	TCGA-61-1736-01B-01W-0722-08	TCGA-61-1736-11A-01W-0722-08	C	C	G	G	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518273	7518273	C	G	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245R	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518273	7518273	+	Missense_Mutation	SNP	C	C	T	rs28934575	Unknown	TCGA-09-2049-01D-01W-0799-08	TCGA-09-2049-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518273	7518273	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.733	p.G245S	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518275	7518275	+	Missense_Mutation	SNP	C	C	T	rs28934572	Unknown	TCGA-29-2427-01A-01W-0799-08	TCGA-29-2427-10A-01W-0800-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518275	7518275	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.731	p.G244D	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518276	7518276	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-61-2111-01A-01W-0722-08	TCGA-61-2111-11A-01W-0723-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518276	7518276	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.730	p.G244C	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	A	rs28934573	Unknown	TCGA-04-1367-01A-01W	TCGA-04-1367-10A-01W	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0013	241	S	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	A	rs28934573	Unknown	TCGA-24-2254-01A-01W-0722-08	TCGA-24-2254-10A-01W-0722-08	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0013	241	S	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518284	7518284	+	Missense_Mutation	SNP	G	G	A	rs28934573	Unknown	TCGA-20-0991-01A-03D	TCGA-20-0991-10A-01D	G	G	A	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7518284	7518284	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.722	p.S241F	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0013	241	S	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518288	7518296	+	In_Frame_Del	DEL	TGTTACACA	TGTTACACA	-	novel	Unknown	TCGA-61-2088-01A-01W-0722-08	TCGA-61-2088-11A-01W-0722-08	TGTTACACA	TGTTACACA	TGTTACACA	-	TGTTACACA	TGTTACACA	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518288	7518296	TGTTACACA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.718_710	p.MCN237in_frame_del	1.000:1.000:1.000:1.000:0.999:1.000:1.000:1.000:1.000	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	191170.0013	241	S	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-59-2363-01A-01W-0799-08	TCGA-59-2363-10A-01W-0800-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-59-2350-01A-01W-0799-08	TCGA-59-2350-11A-01W-0800-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-13-0891-01A-01W	TCGA-13-0891-10A-01D	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-25-1319-01A-01W	TCGA-25-1319-10A-01W	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Broad454,Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-61-1728-01A-01W-0699-08	TCGA-61-1728-11A-01W-0700-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518991	7519015	+	Splice_Site	DEL	TAAGATGCTGAGGAGGGGCCAGACC	-	TAAGATGCTGAGGAGGGGCCAGACC	novel	Unknown	TCGA-09-2044-01B-01W-0799-08	TCGA-09-2044-10A-01W-0799-08	TAAGATGCTGAGGAGGGGCCAGACC	TAAGATGCTGAGGAGGGGCCAGACC	-	-	TAAGATGCTGAGGAGGGGCCAGACC	TAAGATGCTGAGGAGGGGCCAGACC	Unknown	Valid	Somatic	Phase_I	Capture	Illumina_Capture			Illumina GAIIx	17	7518991	7519015	TAAGATGCTGAGGAGGGGCCAGACC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	splice_site_del	c.583_560	p.G187fs	1.000:0.987:1.000:1.000:0.996:1.000:1.000:1.000:1.000:1.000:0.998:0.999:0.987:0.923:0.995:0.997:0.888:0.996:0.996:0.816:0.467:0.381:0.265:0.331	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518902,7519014], intron[7519015,7519095])"	no_errors	TP53	191170.0038	189	A	V	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519128	7519128	+	Missense_Mutation	SNP	C	C	T	novel	Unknown	TCGA-23-1110-01A-01D	TCGA-23-1110-10A-01D	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519128	7519128	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.527	p.C176Y	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-23-1122-01A-01W	TCGA-23-1122-10A-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-23-1030-01A-02W	TCGA-23-1030-10C-01W	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-61-2003-01A-01W-0722-08	TCGA-61-2003-10A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-25-2399-01A-01W-0799-08	TCGA-25-2399-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-24-2281-01A-01W-0799-08	TCGA-24-2281-10A-01W-0799-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Capture			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519131	7519131	+	Missense_Mutation	SNP	C	C	T	rs28934578	Unknown	TCGA-23-2077-01A-01W-0722-08	TCGA-23-2077-10A-01W-0722-08	C	C	T	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519131	7519131	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.524	p.R175H	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0030	175	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519186	7519186	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-61-2009-01A-01W-0722-08	TCGA-61-2009-10A-01W-0722-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519186	7519186	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.469	p.V157F	0.1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0007	157	V	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519230	7519244	+	In_Frame_Del	DEL	GGGCAGGTCTTGGCC	GGGCAGGTCTTGGCC	-	novel	Unknown	TCGA-25-2393-01A-01W-0799-08	TCGA-25-2393-10A-01W-0799-08	GGGCAGGTCTTGGCC	GGGCAGGTCTTGGCC	-	-	GGGCAGGTCTTGGCC	GGGCAGGTCTTGGCC	Unknown	Unknown	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7519230	7519244	GGGCAGGTCTTGGCC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.425_411	p.AKTCP138in_frame_del	0.999:1.000:1.000:1.000:1.000:0.996:1.000:1.000:1.000:1.000:1.000:0.994:1.000:1.000:0.985	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	191170.0032	138	A	P	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519259	7519259	+	Missense_Mutation	SNP	C	C	A	novel	Unknown	TCGA-24-2262-01A-01W-0799-08	TCGA-24-2262-11A-01W-0799-08	C	C	A	A	C	C	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	7519259	7519259	C	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.396	p.K132N	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0011	133	M	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7519261	7519261	+	Missense_Mutation	SNP	T	T	C	novel	Unknown	TCGA-61-2000-01A-01W-0722-08	TCGA-61-2000-11A-01W-0722-08	T	T	C	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sequenom			Illumina GAIIx	17	7519261	7519261	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.394	p.K132E	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0011	133	M	T	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
NF1	4763	broad.mit.edu	36	17	26688724	26688724	+	Nonsense_Mutation	SNP	G	G	T	novel	Unknown	TCGA-59-2363-01A-01W-0799-08	TCGA-59-2363-10A-01W-0800-08	G	G	T	T	G	G	Unknown	Valid	Somatic	Phase_I	Capture	"Sequenom,Capture"			Illumina GAIIx	17	26688724	26688724	G	T	SNP	NF1	NM_001042492	human	genbank	54_36p	1	reviewed	nonsense	c.6640	p.E2214*	1	NULL	"HMMSmart_SM00516,HMMPfam_RasGAP,HMMSmart_SM00323,PatternScan_RAS_GTPASE_ACTIV_1,superfamily_GTPase activation domain GAP"	-	no_errors	NF1	613113.0009	2213	Y	N	"Neurofibromatosis, type 1; Leukemia, juvenile myelomonocytic; Melanoma, desmoplastic neurotrophic; Neurofibromatosis, familial spinal; Neurofibromatosis-Noonan syndrome; Watson syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-59-2354-01A-01W-0799-08	TCGA-59-2354-11A-01W-0800-08	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-61-2012-01A-01W-0722-08	TCGA-61-2012-11A-01W-0722-08	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	broad.mit.edu	36	17	7518915	7518915	+	Missense_Mutation	SNP	T	C	C	novel	Unknown	TCGA-04-1356-01A-01W	TCGA-04-1356-11A-01W	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			Illumina GAIIx	17	7518915	7518915	T	C	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.659	p.Y220C	1	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0039	220	Y	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7517815	7517816	+	Frame_Shift_Ins	INS	-	A	A	novel	Unknown	TCGA-13-0897-01A-01W-0421-09	TCGA-13-0897-10A-01W-0421-09	-	-	-	A	-	-	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7517815	7517816	-	A	INS	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.848_847	p.R283fs	0.013:0.012	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0018	282	R	W	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7518264	7518264	+	Missense_Mutation	SNP	G	A	A	novel	Unknown	TCGA-24-1417-01A-01W-0549-09	TCGA-24-1417-10A-01W-0549-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7518264	7518264	G	A	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.742	p.R248W	1	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0010	248	R	Q	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	genome.wustl.edu	36	17	7519195	7519207	+	Frame_Shift_Del	DEL	CGGGCGGGGGTGT	-	-	novel	Unknown	TCGA-13-0723-01A-02W-0372-09	TCGA-13-0723-10B-01W-0372-09	CGGGCGGGGGTGT	CGGGCGGGGGTGT	CGGGCGGGGGTGT	-	CGGGCGGGGGTGT	CGGGCGGGGGTGT	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA	1	dbGAP	Illumina GAIIx	17	7519195	7519207	CGGGCGGGGGTGT	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.460_448	p.T150fs	0.496:0.001:0.001:0.001:0.001:0.996:0.998:0.906:0.998:0.997:0.001:0.001:0.001	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7519096,7519279])"	no_errors	TP53	191170.0026	151	P	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7514743	7514743	+	Frame_Shift_Del	DEL	G	-	-	novel	Unknown	TCGA-36-1576-01A-01W-0615-10	TCGA-36-1576-10A-01W-0615-10	G	G	G	-	G	G	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7514743	7514743	G	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.1009	p.R337fs	0.47	"HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7514652,7514758])"	no_errors	TP53	191170.0035	337	R	H	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	Unknown	TCGA-36-1574-01A-01W-0615-10	TCGA-36-1574-10A-01W-0615-10	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7517845	7517845	C	T	SNP	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	missense	c.818	p.R273H	0.81	"superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	-	no_errors	TP53	191170.0012	272	V	L	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7518270	7518275	+	In_Frame_Del	DEL	TGCCGC	-	-	novel	Unknown	TCGA-13-0717-01A-01W-0370-10	TCGA-13-0717-10B-01W-0370-10	TGCCGC	TGCCGC	TGCCGC	-	TGCCGC	TGCCGC	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7518270	7518275	TGCCGC	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	in_frame_del	c.736_731	p.GGM244in_frame_delV	1.000:1.000:1.000:0.996:0.171:0.996	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53"	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7518224,7518333])"	no_errors	TP53	191170.0019	245	G	S	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7520201	7520202	+	Frame_Shift_Del	DEL	GA	-	-	novel	Unknown	TCGA-25-1634-01A-01W-0615-10	TCGA-25-1634-10A-01W-0616-10	GA	GA	-	-	GA	GA	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7520201	7520202	GA	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.211_210	p.P72fs	0.662:0.662	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	191170.0005	72	P	R	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"
TP53	7157	hgsc.bcm.edu	36	17	7520294	7520306	+	Frame_Shift_Del	DEL	TTGCTTGGGACGG	-	-	novel	Unknown	TCGA-10-0927-01A-02W-0419-10	TCGA-10-0927-11A-01W-0419-10	TTGCTTGGGACGG	TTGCTTGGGACGG	TTGCTTGGGACGG	-	TTGCTTGGGACGG	TTGCTTGGGACGG	Unknown	Valid	Somatic	Phase_I	Capture	Sanger_PCR_WGA			SOLID	17	7520294	7520306	TTGCTTGGGACGG	-	DEL	TP53	NM_000546	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.118_106	p.P36fs	0.000:0.000:0.001:0.000:0.000:0.001:0.001:0.002:0.000:0.000:0.000:0.000:0.000	NULL	"PatternScan_P53,superfamily_p53-like transcription factors,HMMPfam_P53_tetramer,superfamily_p53 tetramerization domain,HMMPfam_P53,HMMPfam_P53_TAD"	"(deletion:cds_exon[7520037,7520315])"	no_errors	TP53	191170.0027	35	L	F	"Colorectal cancer; Li-Fraumeni syndrome; Hepatocellular carcinoma; Osteosarcoma; Choroid plexus papilloma; Nasopharyngeal carcinoma; Pancreatic cancer; Adrenal cortical carcinoma; Breast cancer; Li-Fraumeni-like syndrome,"