Cunningham et al. Plant Cell. (2011). 10.1105/tpc.111.086827 Supplemental Data Set 3. Text File of the Alignment Used to Generate the Tree Shown in Figure 10. >Adonis aestivalis HBFD1 -------------------------------MAPVLLGLKPTLSTGSVVKETNVGSTLAS PLNK----------------TQNSRVLVLGGTGKVGGSTALALSKFS------------- ------PDLRLVIGGRNREKGDAVVSKLG-----------ENSEFVEVNVDS-------- --VRS-LESALE--DVDLVVHAAGPFQQA--EKCTVLEAAISTRTAYVDVCDNTSYSMQA K-SFHDKAVAANVPAITTAGIFPGVSNVIAAELVRSARDENT---------------EPQ R-LRFSYFTAG-SGGAG-------PTSLVTSFLL-------------------------- -----------LGEEVVAYSEGEKVELKPYTGKLNIDFGKGVGKRDVYL----------- ------------------------------WNLPEVRSGHEIL-GVPTVSARFGTAPFFW NWAMVAMTTLLPP-GILRDRNKIGMLANFVYPSVQIFDGI-AGECLA------------- -------------MRVDLE---CANGRNTFGILS------------HERLSVLVGTSTAV FAMAILEGST---------QPGVWFPEEPGGIAISDRELLLQRASQGAINFIMKQ----- ------------------- >Arabidopsis thaliana At1g50450 (HBFD-like) -----------------------------MTRALLLQPYRATVRAASSRETQYDGVPEVK FSDP----------------SRNYRVLVLGGTGRVGGSTATALSKLC------------- ------PELKIVVGGRNREKGEAMVAKLG-----------ENSEFSQVDIND-------- --AKM-LETSLR--DVDLVVHAAGPFQQA--PRCTVLEAAIKTKTAYLDVCDDTSYAFRA K-SLEAEAIAANIPALTTAGIYPGVSNVMAAEMVAAARSEDKG--------------KPE K-LRFSYYTAG-TGGAG-------PTILATSFLL-------------------------- -----------LGEEVTAYKQGEKVKLRPYSGMITVDFGKGIRKRDVYL----------- ------------------------------LNLPEVRSTHEVL-GVPTVVARFGTAPFFW NWGMEIMTKLLPS-EVLRDRTKVQQMVELFDPVVRAMDGF-AGERVS------------- -------------MRVDLE---CSDGRTTVGLFS------------HKKLSVSVGVSTAA FVAAMLEGST---------QPGVWFPEEPQGIAVEAREVLLKRASQGTFNFILNKPPWMV ETEPKEVVLGIYV------ >Picea sitchensis HBFD-like -------------------MHQFGFIMSAPILWHSPIGRRNRNRNGIIWCMSVSSSSERV ESIK----------------SDNGRVLILGATGRVGGSAARALVKSC------------- ------PNVHLVLAGRNREKGAKLAAELG-----------ANTEFYQVSIDN-------- --TKA-LAAALD--GVDLVVHAAGPFQRE--EKCTVLEAAISSKTAYIDVCDDRSYSCLA K-TFHEKAVAAQVPAITTAGIYPGVSNLMAAELVRLARTSSSKETPS----------EPE R-LRFSYFTAG-SGGAG-------PTILATSFLL-------------------------- -----------LREEVIAYRKGEEFRAKPYSGVLDIDFGKGVGKRSVYL----------- ------------------------------LNLPEVGSTHEVL-GVPTVSARFGTAPFFW NWAMSAVVNLAPV-EFLKDRNKVQTLVQLSDPLVRAIDIF-SGELMS------------- -------------MRVDLE---CMDGRKAVGLYS------------HKKLSICVGVAISA FVRAVLEGNT---------QPGVWFPEEPEGIAVEARQQLLERAAEGTINFVMNRPPWMV ETNPKEIGFGIYMQ----- >Selaginella moellendorffii HBFD-like ----------------------------MILSSSGLPPPWQQPAISCRHCSIVCGASSSL AGPG----------------PEKKEVVLIGGTGRVGSSTARALARVW------------- ------PDLQLVLAGRNRERGEGIASEIG-----------AGTKFRAVDIED-------- --LNS-VAQAIE--GAKLVIHSAGPFQRK--NRCTVLEAAIETKVPYIDVCDDLTHAQLA K-SLHNKAVEAGVPAIITTGLYPGVSNIMAAELVRLARESSAGS-------------RPR E-LRFSYFTAG-SGGVG-------PTILATSFLL-------------------------- -----------LSEQVLTYSKGKVVKLDPFSGERIVDFGKAVGKRSVFL----------- ------------------------------INLPEVTTAHEIL-NIPNVTAKFGTAPFFW NWLMSQIAGM----EFLEDYSKVESFARLSDPAVRAIDVL-VGGKVS------------- -------------MRVDLD---CKDGTRSTGLYT------------HPDLSVCAGAATAA FVVPILQGKT---------LPGVWFPEQREGIPIECREGLLEKASTGTSRYAMIVSYYHL H------------------ >Chlamydomonas reinhardtii HBFD-like -------------------------MRRVANTSRATGARCQGAKLVARPCARRAAVHVIC ATGP----------------VPDKSVVVIGGTGRVGSSTAATLLKEF------------- ------PNLKVTVASRSDDSFKAAVERRP---------ELSKAGFQRVDITN-------- --ADS-VQALLKSTGADLVIHTAGPFQRS--KNYAVLEAAIASGTGYIDVCDDTPFAEGA KAAYMEKAKAAGVPAIVSGGIYPGTSNVMAAHIISIARAEYDDNWNYRTPAPGESV-EPK W-LRYSYYTAG-SGGAG-------PTILETSFLL-------------------------- -----------AGEDVIVYKDNKEVVLPPISNRREVDFGPGVGRKGVYL----------- ------------------------------YNLPEVVSGHKYM-RVPDVSARFGTDPFIW NWAMWLTARLVPR-SLLNDRNFVKGFAKLSDPFVRNVDKI-IGEAVA------------- -------------MRVEVD---MVGGKNSSGIFV------------HKYLSQSMGYSTAA FAQSVLQGKT---------QPGVWYPEEKEAL--QDRRQFLQFAATGCSRFELNRSAWAL ESEIKQIGGMIYW------ >Ectocarpus siliculosis HBFD-like -----------------MLRSMTTRRAYQPIGVRCLSPNWFRSSRSSGRDTSTHGHRFRC RSTPSGLGAKGDDGGGARGYDKHARVIVVGGSGRVGGSTVRALRQLA------------- -----GPGLELLVGGRSQRNFVKSVERWRTLPGADEEYDYSDVKFVELDLGD-------- --AAS-LASALD--GCDLVVHTAGPFQRK--TRPEVLEAAIAAKVPYVDVCDDARLATVA K-ALNEKAQEAGVSATISAGIWPGIDQLMAVEACEMLGGAS----------------EVE S-IDFSAYTAG-TGNAG-------TTILSATFLI-------------------------- -----------LCEKVLGFKDGNEIFHEPASGFKKVDFGQSIGEKTRGMCTPAAWLTS-- -----------------TSGRCRCERQGSAVVLVASFTCNQVL-GIPNISTYFGTSPEPW NYLLKGMT-LLPD-SIMGNRDLMQALAEFSEPLVRITDKL-VGATNA------------- -------------MRLEAV---AKDGRKAVLNYA------------HEDLEVCVGIATAA FVVATLRGDV---------RPGVWFPEEAFDD-EAKRGLLFDDATRGAFMWERQEQGATA VEGAPL------------- >Phaeodactylum tricornutum HBFD-like -----------------MIAASHYRRTNSDAKVRLVILYLLICRVASFSVKNTEQSSSCI SLDN----------------LQNKRVLVVGGSGRVGGSCVTQLVL--------------- ------RGSQVTVGGTNAERFLSSRKRWQ-SLFPDICEDLEEVDFVALNRER-------- --SES-VQAVLS--GYDLVVHTAGPFQGKVNTPNGVIEACVENGVPYIDVCDDYCTASAI KTKLAEKAKESKTPCIISTGCWPGVSSLMAKQLLQKSMQAYPDVDQ-----------RDI S-VKFSFFTAG-SGGAG-------VTLLVATFLI-------------------------- -----------LAEKALTVVNGRRKVVTPMETYSTVHFGPVVGDKEVAH----------- ------------------------------LNLLETASVADVL-RIGNVQALFGTAPNFW NGLLGLMA-KLPT-QLLENEDLMRKLSMFSLPIVRLVDAF-AGATNA------------- -------------MRCDISNTKNPDLFRCSAIYA------------HKNLEPCVGECVTA FAAAVLSGAV---------RDGIWFPEEAIQG-GVDAAAVLAAASVGAHTVLVSSEGMEL SLEQVWGTRRKETITMTST >Nostoc punctiforme HBFD-like ------------------------------------------------------------ ---------------------MTDRVLILGGRGRIGSSVAQDLANHT------------- -------QAQITITGRSAEFGKAVSLSSG-----------GQVQFLVLDLVE-------- --VDK-LQNAIA--NSNLVIHCAGPFHYR---DTNVLETCIAQGVNYVDVSDHRSYTSKA L-NFSEQAAAAGVTAIINTGIFPGISNSMVRQGVEQFD-------------------KPE N-IHLSYLVSG-SGGAG-------ITVMRTTFLG-------------------------- -----------LQYPFETWIDGKWQVIKPYSERELVEFPPPYGRSGVYW----------- ------------------------------FDMPETFTLPKAFPSVKTVITKFGSVPDFY NHLTWIAAHIFPK-WLMQRRYMIEFLSHVSHSMTDVTNNF-SGIGVA------------- -------------VRSEVTGQKDGKTAVYCSTVV------------HENTALASGCGTGS IAQLLLEGKL--------KKPGVFAVEEALPT--DLFEEVMQSRGIKINHSWL------- ------------------- >Synechococcus PCC 7002 HBFD-like ------------------------------------------------------------ ---------------------MVRKILILGGTGCIGQRVAAAIA---------------- ------PLGAVTVTGRSGQTAKAL-----------------QGTFLRLDLED-------- --LAA-LEKAIA--NHDLVIHCAGPFHRR---DGRVLQTCIYQGKNYIDVSDHRCLYQKL K-PLTQAAREAGIIAVCNAGVFPGISNSMVRLGVEQLD-------------------EPH Q-IELYYGVAG-SGGAG-------ETVLTTTFLG-------------------------- -----------LGEPFLVFQGGTWQAKQPYSKPTIIDFPAPIGKTTVYW----------- ------------------------------FDVAETFTFAESF-PVETVVTKFGSLPNFY NQLTRAMT-LLPE-SLRQHPRIIQGLSKIGYGMTKLTDSF-TGVGVA------------- -------------MRAIVSGIKDATPQQVTVDFV------------HEHTAIAAGLGVAL VAELVLSEQI--------NQPGLYPVEQIIPS--DLF--LAWARQHQLQLSWNIQPSEKN ------------------- >Cyanothece ATCC 51142 HBFD-like ------------------------------------------------------------ ---------------------M-QRVLIIGGCGRIGSSIAQDIINHT------------- -------EAEVTITGRNPQLGMAALERFQ-----------DKVQFQVLDLSN-------- --QHQ-VKTVVS--KADVVVHSAGPFHYR---NADVLRICIEEGVNYVDVSDQRSFTHKA L-EQHSAAKTAGVTAIINTGVFPGISNSMVRQGVEALD-------------------KAD E-IKLSYIVAG-SGGAG-------ITVMRTTFIG-------------------------- -----------IQQPFEAWIDNRWQTIKPYTGRECLDFGKPYGKAHVYW----------- ------------------------------YDMPETTTLQETF-SVDSVITKFGSVPDFY NYATWMMAHGLPE-KVLKSPKTVEFLAQVSHVMTDVSDRF-TGTGVA------------- -------------MRCDVKGYGSEGAAHYISTFS------------HESASVAAGMGTGS IVELLLKGEL--------VQPGVHPVEQALST--ELFQSILKSRQLTIEKTINFLQENEQ ------------------- >Chlamydomonas reinhardtii unknown1 ------------------------------------------------------------ --------------MSATAASRPYQVVVWGASGFTGRLVAEHLARDY------------- ----QPGKVRWAIAGRDAKKLEQIRSELA-VRVNNPA--VAAVPILTADAND-------- --APA-VGRVLA--QTQVVLSTAGPFARY---GDNVVAQAVEQGTHYADITGEIPWVKRS VQRHHETAKKKGVKILHCCGYDSIPSDMGTFMMVEYCRDKLGC--------------GVS Q-AYSLVGPGR-AGVSG-------GTLESGMNLI-----MNESVSELSELNSNHFTGEGA ARE--------GLPKGPDRPAGLLPRWLPAARTWAGPFIMEGCNAKIVQASHALLRDS-- -------------AAPLEYGKDFKFTEMIAAS-----GAVGAS-LVSAGTMVAGAVLGLA PLRAVARR-FLPA--------PGQGPSEDVQRNGFWTHDL-VAVTDE------------- ----------------------EKPRVVRGKCGD-----------RRDPGYWSTSRMLLE TGLALSLDAERLAADPRLAPGGVLTAAAGCGH--VLLERLR--G-AGFTFEVAGVEGEGV AAAK--------------- >Chlorella variabilis unknown1 ------------------------------------------------------------ -----------------MAPTRAFDVVIWGATGFTGRLVAEHLARDY------------- -----KTGVKWAIAGRSQERLEKLRLELS-EQYGSE---LQEVPILIGDLKS-------- --QPS-LDSIAS--QTTVMISTAGPFALY---GTPVVDAAVRSGTHYVDITGEAPWVSKI IAAYHEEAAAKRVRIVPCCGFDSTPFDLGALLVIDHMRKQLGK--------------QPA K-VLNAVMGSK-GGVSG-------GTIASGMNAI----SEMNSNPALKASARDVYSLV-- -----------PEEAHGSDGEFWGVEWCPELGKYLAPFVMQVVNNRVVHRSNYLNKYD-- -----------------GGSSTLRYQEAVAAK-----SWLAAK-SVQLGTLAVVGAMGQS WMHPLLKK-LLPA--------PGEGPSRETMMTGYFKNRV-VGWTKE------------- -------------------EGGAQPSVVQAEVAD----------PHRDGGYWGTSRMLLE AALCLALQQQELDASPEVLKGGVLTPASAMGI--FLVERLR--N-AGQTFKILEGGASTA ------------------- >Salpingoeca sp. unknown1 ------------------------------------------------------------ ------------------MAGRTYDVVVFGATGFTGSLVVEYLARAY------------- ----ATKSLKWAIAGRNEAKLKDVRASVA-KKLKDET--VNKVDIIVADAKD-------- --APA-LNKMAK--ATKVVLSTTGPFWKF---GSDLVAACVTSGTSYCDITGESPWVKEM IEKHDATAKANKCRIVSFCGMDCIPSDVGCHVVAKHLREKHKC--------------GVD H-INSYILAMK-GGVSG-------GTIASMFNFF-----EQPNFAELRKEMGSPYELIPR -----------DGRPSIRQPDANAVSYEEEVQRYTTPFVMAGVNSKIVHRTNYLLNHI-- ------------------YGPEFRYREKNTVKGDGWGSWLSGW-LTTLGLGAFSVGAYFS PTRNLLRR-MLPK--------PGEGPDEHTRETGKLVMRF-YGVGDS------------- ---------------------AAKPKAVATFVTH------------HDPGYAETATMLAE SAICLAQDTAKLPE-----RYGFLTPIAAMGD--TLVARLQ--A-AGIDITVEDDKNTSS TPPSSL------------- >Synechocystis PCC 6803 unknown1 ------------------------------------------------------------ -----------------MTKPLPYDLIIVGATGFVGGIVCRYLLSHW------------- ---ETAAAKNWAIAGRSQAKLDRLVQSLG--------PQAAHLPTFVVDIKD-------- --EAA-VTTLCS--QTKVVVSTVGPYALY---GETLVRVCAITGTDYCDLTGEVQWVQQM IQKYEAIAKQSGARIVHCCGFDSIPSDLGVYYLQQQSQRRWGE--------------PCI R-VKMGVKACQ-GGISG-------GTIASGINLI----QEAIADPSTRQALRNPYILCFK -----------PDHRSDHPPSLIPVQNDPIFSGWTAPFVMAGINTPIVLRSNTLQNEV-- ------------------YGEGFQYEEGILTGPGII-GWLAAQ-GIKWSLDLMALALAIG PSRWLLLQ-ILPK--------PGEGPTEEAQQQGFYDLRF-WGETAS------------- -----------------------GQSTMVKVTGD------------QDPGYGSTAKILAQ AALCLAKDRPKSSL-----QGGFWTPAASFGQ--DLIHRLI--DYAGLTFTEENGSTL-- ------------------- >Ralstonia pickettii unknown1 ------------------------------------------------------------ ------------------MPAPDYDVVVFGATSFVGQILTRYLSEHL------------- --SGDGEALRWAIAGRSEAKLLDVKRALG--------AAGESLPIIVADAAN-------- --EAQ-LRALCA--QTRVVVSTVGPYALY---GEPLIKVCAESGTDYCDLTGETQWIKRM IDKYEATAQRSGARIVHCCGFDSVPSDMGVYFLQQHAMRQWGT--------------PVT Q-VKLRVKTLK-GGASG-------GTVASLVNVV----QEAAADPALRRELADPYALCPR -----------GHGFTARQRSVRGAAFDADFNVWIAPFVMAAINERVVHRSNALSGNA-- ------------------YGNPFLYDEAVITGAGLS-GRMKAM-TMVAGLAAFMLGIVIK PARIVMQRFLLPK--------PGEGPTPAAQLAGRYDLRL-FGRTDQ------------- -----------------------GNTLRVKVTGD------------RDPGYGSTGKMLGQ AAISLALDHTKDGLKTG-RPGGFWTPATMFDD--RFIERLT--RHAGLRFERI------- ------------------- >Phytophthora infestans unknown1 ------------------------------------------------------------ ------------------MS-KRFDVIVYGATGFTGSLVARYLAAES------------E SALSSPSALKWAVAARSEAKLTQMKEQLKDRLPEVAPELIDAIPVVVADSGS-------- --EES-LAMMVQ--QTNVVVSLVGPYKLY---GELLVKVCAENGVHYCDLTGEIVWIEEM TAKYAAIAAKTGAVLVNCCGFESIPSDVTTFLVADRIQKKFNS--------------ATS T-VDLYFTEFK-GEASG-------GTLASVFAVM------ETSTSKQLLASRNPFFLTDE KTIAEKQ----QAGLVAPNTSGIAIKYDTAMGFWHSLFIGGSVNQAVVHRSNYRLKNK-- ------------------YGDKFVYHERMAIG-----GLFMQL-LATFGTIVVSIMLYFG WTRALLKR-LARA--------PGQGPSEESMLQGYFVAEA-AGYTDD------------- ----------------------GKLAVKAKTVGS------------GDPGYRLTSRLISE CAFCLAKDEFGDAKS---LKGGFYTPASAFGH--KLADRLQ--TKKFITFELKDMA---- ------------------- >Ectocarpus siliculosus unknown1 ------------------------------------------------------------ ----------------MSDSSNKYDVVVFGATSFAGQLVCEYYLANY------------- --GASPPTFKWAVAARSESKLTALKERLA-SEIDSA---ASTLPTIVADSLD-------- --DEA-VGGMVS--QAKVIITTVGPYAHY---GSKVVAACSAAGVHCCDLTGESLWVKGL IDKHHEEAERTGAKIVPSCGFDSIPADLGTLMMVEYMKRTHGL--------------SPD D-VRYYFGASK-GGVSG-------GTIASVLDIF---EQVWSGGKAITSKLADPLLLT-- -----------ATPGFGKAADPGGLGYDSLAKSWTASSVFASHDSKIVFRSAGLLG---- ------------------YPETFRYKEVMGFKGLLK-GFLPAV-FSTIAFGIGGFLMVIP VTRKFIAKKFLPA--------PGEGPSKELRDSGYFWINF-LASGRS------------- --------------------GDGKDVVCRGKVGS----------DKGDCGYKETAKMLAE CGLCLALDDLEY------KKGGVLTTASAMGM--PLVDRLN--K-AGMTFKILDE----- ------------------- >Thalassiosira pseudonana unknown1 MEVVDKKTPITFGPIVFISSLFLGVPFLLTVLLPLTIVSAPIHFFAALLINGKLFSFSKA TSNTIVDRSGDQSIIIAPRESRKYDVVLLGSTGFTGKLATAYLAKQY--------GACCF LHSWKRRNGKWAIAGRSKSKLESTLKSIA-KDLGNDE--VLKVDTIIVDTMD-------- --RST-LKALVD--NTRAVITTAGPFVKY-------------------DITGEVQWNKSM MQQYESTAQRTGAKIVSLCGHDSIPWDLTVRSLSEKLHESCND--------------ELV S--VECLNEMK-GDVSG-------GTLATVYESIDRGIWEFEWKSILPSSTLDVYKRLPD GCESTFS----VSSDLPVTVSPCRNPATRFVNRWCGPFVMAAINMDVVGRSISLSKHG-- -------------------NPTVTYREAAVQE-----SFMDAF-SMWFGTVILGTLIINP ITRPLVKR-ALPQ--------PGQGPSETVRKEGYLCVTG-YGVGAE------------- -----------------------GNVAESAMYFP------------HDGGYQSTARMLVE SGLCLALNEDRHEM----SQGGFYSPAGLMCA--ALLDRLV--N-SGTKFAIRSS----- ------------------- >Phaeodactylum tricornutum unknown1 -----MPSPVTQDGRTVPSVSAATFLATVASLPVWALTVLPLSLFYQAGKVIMKPVLPKA EQPRLDTGYHVSDSDILPRRERKYDMVVLGATGFTGRLAVRHLAKTY------------- ---GVNKSVKWAIAGRSEAKLDKVKRELA-DELDIQE--VESIDTIIVDTTR-------- --TSS-MPALVK--QARCVATTAGPFALF---GSPVVEFCAKFGTHYVDITGESDWVKAM IMKWGETAQKSGARLVTFCGHDSVPWDLSVMKLQEALQKEFKD--------------DLT S-VTFWDEAV--GGAPG-------GTIATLFSAV------DGKSVKAPHADFDPFLRLMN GEKSEYVCRS-DGPTWIHKSKSPWDDTGAWFGRWTTPFIMAQVNGAVVRWSHALREQG-- -------------------SKSLTYTEFAVTK-----DFKTAF-VNHVGLIIVGSMMLNP LTSGLLKKYVFPK--------VGEGPSMKNMEDKHYLCIFGEGIGIN------------- -----------------------GNRAESIMYFD------------KDAGCLETSRMLVE SGLCLALEEDKVPA----KHGGFWPPAAGLGN--VLLKRLL--E-TGTSFEARAISEASV RHSLE-------------- >Aspergillis niger unknown1 ------------------------------------------------------------ -----------------MESNKQYDLIVLGPTGYTGRFCADHIVKNF------------- -----PTNLKWALAGRSLSKLENIAKELK------NVNPDRADPDLLPVQLN-------- --REE-LHPLVQ--KTRVIINCVGPYCLY---STPVIEACASNGTHYVDATGETHWVKEI ISEYHETAKANGAVIIPCVGIESAPADLLAWATVKRVREDLSC--------------HTR S-ITGDIHEIKSSGASG-------GTLSTVLTFF------ENVPPSEMRKISTPFALAAA PPP--------KDIPREPLWTRLLGIRSVRDLGILTTSPSGLADITTVHRSSTLMPEF-- ------------------YGPRFYFRQFLRAR-----NAFTGI-LWHYAFLFAVTALLLP PIRTLVRKYIYTP---------GTGPTLEDSVNDFVEYRA-VATADQ------------- --------------------DTAKPQRVLGKLRY------------QGTMYEFTGLSLAE AAMTIIENEEKVKKV---SRCGIVTTAT-LGQ--EFIDRWD--K-VGCHIETQVVDN--- ------------------- >Arabidopsis thaliana At5g39410 unknown2 ------------------------------------------------------------ -------------MNPTQKPEPVYDMVILGASGFTGKYVVREALKFL------------- QTPSSSPLKSLALAGRNPTRLTQSLEWAA-RPNPP----PSSVAILTADTSD-------- --PDS-LRRLCT--QTKLILNCVGPFRIH---GDPVVSACADSGCDYLDISGEPEFMERM EANYHDRAEETGSLIVSACGFDSIPAELGLLFNAKQWVSPSVP--------------NQI E-AYLSLESDK-KIAG------NFGTYESAVLGV--------ANAEKLKELRRSRPRRPR -----------PTICGPPA-KGPTLENQKTIGLWALKL--PSADAVVVRRTLTTLTEKPH GLPGINESPEQIQKREAFWSSIKPA-HFGVKITSK--SLFGIF-RYVTLGVSLGLLSKFS FGRWLLLK--FPS-VFSLGWFQKKGPSEEEVESATFKMWF-IGRGYS------------- ------------EESLASQGETKPDLEIITRISG------------PEIGYITTPITLVQ CGLIVLGQRESLVK------GGVYTPGIVFGS-TDIQQRLE--D-NGISFELISKIKTQG ------------------- >Picea sitchensis unknown2 ------------------------------------------------------------ ------------------MEDERLDAVILGASGFTGKYVVRYFLAQL------------- -DRDGGQRINIGIAGRSRSKVAEALRWAA-APSLP----PANIPIIEADVTS-------- --PPS-LAALCR--RTKLVLNCVGPYRLY---GEPVVSACVEGGVDYLDITGEPGFMEKM EAAYHQRAEETGSLVISACGYDSIPAELGVIFHSKQWKPPSVP--------------HSV D-SYLALESDK-RIVG------NIGTFQSAVLGV--------ANVHDLQKLRRSRPRRAK -----------PQIPGPPARKAKLIEHISSIGLWALKL--PSSDAIVVRRTQTFLAEDPQ GLPGVNENSDFAEKRKNFWSEVKPL-HYGVYIGYK--SLLSVA-GTIFTGLNVLLLGSFG WGRSLLLK--YPE-IFTLGLFKKTGPTEEEVKSATFKMTF-LGHGYS------------- ------------DESCLLQQKTKPDMEIVTRISG------------PEVGYVTTPITLVQ CALILIDQRHSLPK------GGVFPPGIVFGP-TDLQERLE--K-NGISFEVLSKRTIS- ------------------- >Selaginella moellendorffii unknown2 ------------------------------------------------------------ ------------------MESAAADVIILGASGFTGKRVLGEFLRKL------------- -----PEDRKVGIAGRSRQKLEESLSWAL-GHTSEEQRLKSSVPIFEADVHD-------- --MAS-LRGLCS--KTKLLVSCVGPYRLY---GEPVVAACVEAGIDYLDITGEPEFMERM RAKYHEQAVDRESLVVSACGFDSVPAEFGVIFNTKQWQGSSKP--------------NSI D-AYLTLRSST-RMKG------NFATFESAVLGI--------ASVGELQKLRKSRPIKSP R----------LQIPGVPL-KRPAVHWEDAVNSWAVKI--PSSDAVLVRRTLATVAENPD GLPTASKHQEQSLRQ---WTDIKPV-LFGVYLSVK--ELWRVC-FLLLTGFILYVLANFG WGRKLLLS--YPE-VFTGGVFSKTGPSQEEIDNSSFSMVF-VGRGFK------------- -----------DASKVPPGKKQQPDMEIITRVTG------------PEIGYVTTPIILVQ AALLVLENRDKLPK------GGVWTPGVAFGT-TDYEQRLQ--N-NGLSFDVISKH---- ------------------- >Chlorella variabilis unknown2 ------------------------------------------------------------ -----------------MAASRPHDLVVLGATGFTGNRICKEVLNSG------------- ------FSGKWAVAGRDRVKLERLAASLA-GNDG------NEPSIVVADVAD-------- --PAS-LLEMAK--SCRVLITTVGPFRHW---GEPVVKACVEAGTDYLDVCGEPEFIERV ELLYNETAKQAGCYLASAVGFDSVPGDLGVAYTMSLFKPPARC--------------TVV E-TALTIRGGP-SGFKG-----HYPTYESAVHGF--------ASAGELRKLRKEAEQ--- ----------------------------------------ARADASVVRRSMQRLVEA-- ---------------------GQPAANVSVVFTLP--SRYYLT-LWQGFGSMFQFLAGKP WGRSLLLQ--YPR-LFTYGMFSHEGPSERQLSEASFQFTN-IAKGYS------------- -------------KGAPEAPDQAPDIEIVTRVSG------------PEPGYISCAIFVVQ AAITLLEERQSLGL------PGVHTPASLLRD-TTYIDRLR--S-RGIKFEQVQDATVQ- ------------------- >Ectocarpus siliculosis unknown2 .. ------------------------------------------------------------ ------------------MASRDMDILVVGASGFTGAHVCKRLARSV------------- -ADGSWAGVSWGIAGRSRTKLEDKVLAPL-RAEGLAV--PGEESITVVDNSD-------- --AAA-LRKAVG--RARLCLNCTGPYRFL---GESVVSACVDSGTDYIDLCGEPEFMQRM TLKFHEAAEAKGVLIMHACAFDSVPADLGCLFAAKQFVSPAVC--------------SSV S-SFVTLNVGP-SGYSG-----HATTFEAAVHGF--------GSAADLRKVRKEVQAKFP PSQIP------RVGARPVERGGPFYEQTPGIEAYCFKF--PGADSAVVRSTQNSLAGRGE G------------------AGLCP--HYSAYFTAG--QLWGAT-QMTLFGGVFQTLAKSG WGRNLLLN--NVG-AFSRGLFSHEGPTEDQMNETSFEMTF-LAKGYSTPPTAAEPPATPA AGADPGEVEAAAAAPAPAPPTVEPDVTVVTRVKG------------PEPGYVATPIIFLA VARCLLEERSSLPV-----SGGVHTPGSVLVS-SSLVDRLG--K-DGVTFEVVG------ ------------------- >Thalassiosira pseudonana unknown2 ------------------------------------------------------------ -------MTSYPTNRRERFASRSIDVIVHGATGYTGRRVVRHLVTKH------------- ------PSLNVAICGRNKDKLAVVAAEVA-WDDAKK---ASSVFVVSDASKDTSGAESAN DGSQE-LIQVFS--QSKIVIACAGPYRQC---GMPIITAAVASGCDYLDLCGEPQFFDQV LISLDRKARSSGVLAISAAAFDCVPAELGAALAERELLKQHPG--------------AKC A-GVEVIHTMQ-NVSGA-----NATTFHAAVDGF------YAASSGELAASRKKVKESYP EFQETMPPSRPKEWPKIPETPGLMPGHNEGLGLRTLKF--VGADASAIRSSWRYLRSR-- ------------VPEHARKGKNVPEPRLSVLMGMDSKDTMSAA-KLIVYGATFSTLAQFK WGCDVLHN--YPE-AFSGGVFTSKGQSEEELQNAKFTTYV-TAYGSN------------- ------------------YSDGDSSQVARVKVGG------------PEPGYVATPALIVA LALTILEAGK--YEVGLAFDSGCTLPGALFGDCEKVYDNMR--A-EGVSFDVVQEFGGES QSPV--------------- >Salpingoeca sp. unknown2 ------------------------------------------------------------ -----------MSEAKKTQQPRAVDIVVFGATGFTGQYVVQYLRGTV------------- ------QDKSIAISGRSADKLAALNRKLG-----------TNYPVIVADVKD-------- --EES-IVAMAQ--QARVCLNCVGPYRFF---GEPVVKACAAVGTHYLDICGEPEFIERM EYLYDEQARQTGATIISACGFDSIPADLGTMFTVKQFTNGQIP--------------SSV E-SFLQIKSGE-AGTKV-----HFATFESAVHGF--------ASAGELRDLRRKKGKVTV -----------PVVGRKLKRPGMLPEWREDGHGYCIPF--PGSDASIVRRSQQYLQAH-- ------------------GAEVQPV-QYAAWFSLP--SGFWTG-VMMAAGTVFGALANFS FGRSLLLK--FPE-LFTLGVFTHDGPTEEQMRATSFEMNF-VAKGYT------------- -------------SAAAAEARGAPDVTVKTRVSG------------PEPGYVATPICIVQ CALALIGNEGKVPR-------GVLTSATAFRH-TDILQRLN--G-AGVKFEVL------- ------------------- >Homo sapiens unknown2 ------------------------------------------------------------ ----------------MATEQRPFHLVVFGASGFTGQFVTEEVAREQ------------- VDPERSSRLPWAVAGRSREKLQRVLEKAA-LKLGRPTL-SSEVGIIICDIAN-------- --PAS-LDEMAK--QATVVLNCVGPYRFY---GEPVIKACIENGASCIDISGEPQFLELM QLKYHEKAADKGVYIIGSSGFDSIPADLGVIYTRNKMNGTL----------------TAV E-SFLTIHSGP-EGLSI-----HDGTWKSAIYGF--------GDQSNLRKLRNVSNLKP- -----------VPLIGPKLKRRWPISYCRELKGYSIPF--MGSDVSVVRRTQRYLYEN-- -------------------LEESPV-QYAAYVTVG--GITSVI-KLMFAGLFFLFFVRFG IGRQLLIK--FPW-FFSFGYFSKQGPTQKQIDAASFTLTF-FGQGYS------------- --------------QGTGTDKNKPNIKICTQVKG------------PEAGYVATPIAMVQ AAMTLLSDASHLPK-----AGGVFTPGAAFSK-TKLIDRLN--K-HGIEFSVISSSEV-- ------------------- >Caenorhabditis elegans unknown2 ------------------------------------------------------------ ------------------ME-ARYDVVIYGATGVTGGKIFETLISCG------------- ----KFDNYSIAIAGRSEKKLEEVLEKLE-KSTGTSL--KTRIGLLVCDSTN-------- --EES-MGKMAR--RAKLIVNAVGPFRLH---GEAVVKAAVENGANQIDVAGEPEWIERM EAKYGQMAKNNNVYIVSACGWDSIPADFGVKLLKRYFDGHL----------------QRI D-AFLQLHFGP-SGYSF-----SATSLQALLLGF--------NGAPDLGSLRHSIMPKKI D----------HLLAPNKKRHFLWKIEEKGSEGWAMPF--LGADKSIVTRSQYFDYVM-- -------------------NNVKPV-RFTPFTRFE--SRWNAL-LLAALMGLLKTFSKYG TMQRFIMR--YPE-LCSGKLFSKSGPSEEQMKEATFTYQF-YGYGYG------------- ---------------RGDPRDREPKKKLLVTCTG------------PDVGYIATSGCVLS SVLVFLKEKEKLPK-----SGGVYTTAYAFEN-TRLIDFLL--D-FGIKFDIEMPSKL-- ------------------- >Drosophila melanogaster unknown2 ------------------------------------------------------------ ------------------MSGDRLDVIIFGASGFTGKYTVFEAVTVL------------- ------RGLRWGIAGRNREKLEAVLKEMG-AKAKKD---LSQVPIFIADVND-------- --QAS-LLEMAK--KCRIVVNTAGPYRFH---GENVVKCCIESGTHHVDVSGEPQYMETM QLRYDQLAREKGVYVVSACGFDSIPADMGVVFVEKNFDGVV----------------NSV E-TFLETGIKE-GGSGGGTAGLNYGTWESAVYGL--------AHSDELRGIRKQIYPQR- -----------LPRFYPFLKPRPLVFRSTEVDKVCLPF--PGSDRSVVMRSQRFLYDQ-- -------------------DKKRPV-QMQAYVGFS--SWLVAG-GVIFFATIFGLLSKFK LGRTLLLN--YPG-LFSGGLASRSGPSEESMERTYFKMTF-KASGWL------------- --------KSDRLAESSNQYTESPTKTLMVRVSG------------MNPGYGATCVAVLS AALTILRESDKMPS-----TGGVLPPAAAFSK-TGLISELEKHD-HGIKFEILANK---- ------------------- >Arabidopsis thaliana At4g33150 SDH ------------------------------------------------------------ ------------------MT-KKSGVLILGA-GRVCRPAADFLASVRTISSQQWYKTYFG ADSEEKTDVHVIVASLYLKDAKETVEGIS------------DVEAVRLDVSD-------- --SES-LLKYVS--QVDVVLSLL-PASCH----AVVAKTCIELKKHLVTAS----YVDDE TSMLHEKAKSAGITILGEMGLDPGIDHMMAMKMINDAHIKKGKVKSFTSYCGGLPSPAAA N-NPLAYKFSW-NPAGAIRAGQNPAKYKSNGDII------HVDGKNLYDSAARFRVPNLP AFALECF----PNRDSLVYGEHYGIESEATTIFRGTLRYEGFSMIMATLSKLGFFDSEAN QVL-STGKRITFGALLSNILNKDADNESEPLAGEEEISKRIIKLGHSKETAAKAAKTIVF LG-FNEEREVPSLCKSVFDATCYLMEEKLAYSGNEQDMVL-LHHEVE------------- -------------VEFLESKRIEKHTATLLEFGDIKN------GQTTTAMAKTVGIPAAI GALLLIEDKI--------KTRGVLRPLEAEVY-LPALDILQ--AY-GIKLMEKAE----- ------------------- >Selaginella moellendorffii SDH ------------------------------------------------------------ ------------------VVSEYTNILILGA-GRMCEPTLMYLTENA--------FEDYA DTSKPPKQVFVHVGSLYLEDASKVVEGVE------------NALAIQIDVMD-------- --EQQ-LKSQVQ--KVEVVISLL-PPSFH----ERVAVACIELKKHLVTAS----YVSKD MALLDSRAQAAGVTLLCEMGLDPGIDHMMAMKMIDASHERGDKVRVFESYCGGLPSPEAA N-NPLAYKFSW-NPTGAIKAGRNAATYKHENKII------RVPGERLFGAAVSFRIPQYP AYALEVL----PNRDSLMYGDLYGISQEAATIFRGTLRYEGFGQIMDTLGKLGYYNSDNH PLL-ASSTETTYAAVLEALILQLSTSYNGLCAEELARIIS----SDNLDVAKRVLSCIRF LG-LDSQEIVPRSCKSAFEVLCSRMEEKLVFRANEQDLVL-LHHELE------------- -------------VVYEDSRSAERHSATLVAVGESCNQLKNESRRPHSAMARTVGLTVAI GAELLFTGRL--------KSRGVIRPLQPEVY-VPGLEILG--KL-GLGVVES------- ------------------- >Phaeodactylum tricornutum SDH ------------------------------------------------------------ ------------------VPNISKRILVLGA-GMVSKSVVDLLGRSA------------- -------NQEITVASENHEEARLTAAFSK------------HDRHVGLGVVN-------- --DVKRLSDHIE--SADKVVSLL-PPPMH----FQVALDCIKHKTDL------------- -----GRAKEAGVIILNESGLDPGLDHMSAMKKIDDILSRGGRVTVFASVCGGLPSPEAA D-NPLKYKFSW-SPKGVIQTSQSDARYRWEGQVL------QVHGSDLLAAAAPFLH-AWP KLGLECL----PNRDSLRYEHIYNIG-----GAKATLRYRGFSSCSYGL----------- ---------------FCLRDQRGGSLNVEDFILACV--------ADNFDEAVAVLDTLIW LG-VLPGHIPVSG-SNIVEAFFNFLEDKLRYKESESDMVL-MHHIIE------------- -------------ASFERA-RSERHLASPQVFGE----------EGISAMAKCVGYTTAS SAGLILSFALD-------DLLGLLLPTSPRVY-EPVLAAKK--ESPSTKRAHQIRQTR-- ------------------- >Thalassiosira pseudonana SDH ------------------------------------------------------------ ------------------LGEREQNILLLGA-GKVASSFAEYLGRSK------------- -------TNTITVASQYEADAMKTARYAT------------RGKAVTCDLSQ-------- --PGDQLKYLIQ--EADIVVSLL-PAQMH----PTIAEECISMKTDLVTAS----YESEE MRALCSSAEEAGIAILNEMGLDPGVDHMSAMKIIDDVHERGGEITSFSSVCGGLPSPEVA NHNPLLYKFSW-SPMGVMKASQNAAVYRKDNQLV------VIDGADLLASAEPFD--AWK SLNLECI----PNRDSLVYGEKYGIE-SAATIFRGTLRYQGFSSLLHVLKNMGLLDNKG- ------TGAVSWYDALDDLRKQGGHADLRKFVLACA--------GGDRDLGLRAYNCLSW LG-LKEHTPVSEP-SSIAKSFCDVLQQHLQFEEGERDMVL-MHHDIR------------- -------------AVFGDG-SNETLSCSMELYGD----------DRMTAMCKTVGFTAAI GTKLILEGGI--------TNKGLLLPTSKDVY-TPSLELLR--EE-GI------------ ------------------- >Phytophthora infestans SDH ------------------------------------------------------------ ------------MAEVSVSSPKKRKVVCFGA-GLVASPLVEYLSREQ------------- -------GNEVHVVSGIEREVKEMMRKIS----------RRNIKPHVVNVAE-------- --DAAGVDKLCA--EADCVVSLL-PATMH----TTIAQRCIQHATPLVTAS----YVSPE MKELDARAKKAGIPILCEIGLDPGMDHMSAMKVIDEVKALSGKVMTFSSVCGGLPAPEAA D-NAIGYKFSW-SPRGVLTAALNAAQYRKDGKVI------NVAGEDLLNRSERVN--FLP AFNIEQI----PNRNSLPYGDIYGIP-EAHSLYRGTLRYGGCCQILYQLRKLGLFDMDP- ----SKPIPATWPDLLTQLGGFQGLRE-------------------------DAHGFLQW LGAFDKSNPVVKA-PSILDAFCALLQDKLSYQPGERDMAI-MHHEFG------------- -------------IEYEDG-KKEKRTSTFVGYGS---------EKGDTIMAKTVGLSAAI GVQLILQDAV--------QGRGVLTPTTPDIY-GPALARLE--VE-GVRFIEKTFPQH-- ------------------- >Drosophila melanogaster SDH ------------------------------------------------------------ ---------------MEGSSESDKKVLVLGA-GMVSAPLVEWLHREK------------- -------DVSITVCSQVKEEADRLAQQYA------------GVDSVYLDVNE-------- --STGHLQELCG--RADVVVSLL-PYSLH----GMVARYCVAEGTHMVTAS----YLNDE ISGLHEEAKAKGVTIMNEVGLDPGIDHLLALECIHEVQDKGAVVESFVSYCGGLPAPEHS N-NALRYKFSW-SPRGVLLNTLSAAKYLSQGQIV------EISGGGELMSSPRSLD-FLP GFALEGF----PNRDSTKYGNLYGLGRDVHTLLRGTIRYKGFSESIKPMQLLGLIDPEPH ALLHPSGPDVTWRQLVIHLMGMSDSTIFYENL------------KQKLTERIGDVDGIES LG-LLDDTPVVKL-NTPLDTLSHYLSKRLAFERDERDLVV-LRHEVG------------- -------------IRWPDG-RREERGINFVVYGQ---------PQGHSAMAMTVGKPAAI AAKMILDGEI--------QERGVLLPFTPDIY-RPMLQRLR--SE-GLTATETSRWLN-- ------------------- >Homo sapiens SDH ------------------------------------------------------------ ------------------MG-TRRKVLVLGS-GYISEPVLEYLSRDG------------- -------NIEITVGSDMKNQIEQLGKKYN-------------INPVSMDICK-------- --QEEKLGFLVA--KQDLVISLL-PYVLH----PLVAKACITNKVNMVTAS----YITPA LKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHS N-NPLRYKFSW-SPVGVLMNVMQSATYLLDGKVV------NVAGGISFLDAVTSMD-FFP GLNLEGY----PNRDSTKYAEIYGIS-SAHTLLRGTLRYKGYMKALNGFVKLGLINREAL PAFRPEANPLTWKQLLCDLVGISPSSEHDVLKEAV---------LKKLGGDNTQLEAAEW LG-LLGDEQVPQA-ESILDALSKHLVMKLSYGPEEKDMIV-MRDSFG------------- -------------IRHPSG-HLEHKTIDLVAYGD---------INGFSAMAKTVGLPTAM AAKMLLDGEI--------GAKGLMGPFSKEIY-GPILERIK--AE-GIIYTTQSTIKP-- ------------------- >Saccharomyces cerevisiae SDH ------------------------------------------------------------ ------------------MG---KNVLLLGS-GFVAQPVIDTLAAND------------- -------DINVTVACRTLANAQALAKPSG-------------SKAISLDVTD-------- --DSA-LDKVLA--DNDVVISLI-PYTFH----PNVVKSAIRTKTDVVTSS----YISPA LRELEPEIVKAGITVMNEIGLDPGIDHLYAVKTIDEVHRAGGKLKSFLSYCGGLPAPEDS D-NPLGYKFSW-SSRGVLLALRNSAKYWKDGKIE------TVSSEDLMATAKPYF--IYP GYAFVCY----PNRDSTLFKDLYHIP-EAETVIRGTLRYQGFPEFVKALVDMGMLKDDAN EIF---SKPIAWNEALKQYLGAKSTSKEDLIASIDSKAT-----WKDDEDRERILSGFAW LG-LFSDAKITPR-GNALDTLCARLEELMQYEDNERDMVV-LQHKFG------------- -------------IEWADG-TTETRTSTLVDYGK---------VGGYSSMAATVGYPVAI ATKFVLDGTI--------KGPGLLAPYSPEIN-DPIMKELK--DKYGIYLKEKTVA---- ------------------- >Aspergillus niger SDH ------------------------------------------------------------ ------------------MPVAGSKVLLLGS-GFVTKPTVEVLSKA-------------- -------DVNVTVACRTLESAQKLCEGFK------------NTKAISLDVTD-------- --DAA-LDKALE--QVDLAISLI-PYTFH----ANVIKSAIRTKKHVVTTS----YVSPA MMELDEECKKAGITVMNEIGLDPGIDHLYAVKTISEVHAEGGKITSFLSYCGGLPAPECS N-NPLGYKFSW-SSRGVLLALRNAAKFYKDGQEF------SVAGPDLMATAKPYF--IYP GFAFVAY----PNRDSCPYRERYNIP-EAQTVVRGTLRYQGFPEMIKVLVDIGFLSDEGR EYL---NTPIAWKEATKQILGATSSAEKDLEWAIASKTA-----FANNDDRDRIISGLRW IG-LFSDEQITPR-GNPLDTLCATLEKKMQYEEGERDLVM-LQHKFE------------- -------------IEHKDG-QKETRTSTLCEYGV---------PGGYSAMAKTVGVPCGV AVKLVLDGTI--------NQKGVVAPMTMDIC-APLIKTLK--EDYGIEMIEKTL----- ------------------- >Salpingoeca sp. SDH ------------------------------------------------------------ ------------------MP----KILLLGA-GFVAGPCLDYLLRRD------------- -------DNTITVACRTLERAQELAGDRQ------------RTAAISLNVKD-------- --SEA-LVAEVQ--KHDIVISLI-PYTYH----PLVIEAAIKVKKHFVSTS----YVSPK MASFDQAAKDAGITVMNEIGVDPGIDHLYAKKIIDEAHEEGSKVLEFTSYCGGLPAPEAS N-NPLGYKFSW-SARGVLLAAGNSCKYFEHGKKV------EIEAPYVLSKGVRNIN-IYP AFAFEGY----PNRDSTPYEERYNIP-ECLTILRGTLRYKGTPLLVQSLALVGFLNDHPQ DYLQPTAPDMAWKDVLAKMLGCTND-EASLAKAAAERAG-----IRDHPEERRIISAMKW LG-LFSDDVCPKK-VSLLDSLAHTLADKCAYQPGERDMIM-MQHKFR------------- -------------IQKKTG-DEYVVASTMLEYGI---------PFGATAMARTVGIPCGI AVQLILDGKI--------TRKGVFAPMTKDIY-QPLIAELE--KE-GIGCKEEYLDEWTH ------------------- Supplemental Data Set 3. Cunningham et al. Plant Cell. (2011). 10.1105/tpc.111.086827 1