Supplementary material for Lieb et al. (April 3, 2001) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.071049998
Supplemental Figure 7Fig. 7.
Hypothesis of the evolution of the molluscan hemocyanin decamer (Lower) starting from a di-pentameric ring (Upper). The latter is enlarged by three subsequent steps of gene duplication, fusion, and evolution, producing the eight different FUs that constitute each subunit. The two structurally identical subunits within each dimer (the repeating unit) are drawn in red and blue, respectively. Only two of the five dimers within each di-pentamer are shown. The central collar/arc complex is indicated by yellow arrows, the peripheral cylinder by gray arrows.