Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

Supplemental Data

Files in this Data Supplement:

• Spplemental Figures (.pdf, 238 KB) - Supplemental figure 1. Standard curve generated from diluted phosphorylated GST-hCAR by PKC. Supplemental figure 2. Localization of the ERK1/2-interacting site on the hCAR structure. Supplemental figure 3. De-phosphorylation of T38 by ERK1/2 siRNAs leads to increase CAR- mediated NR-1 transcriptional activity.