33 204 HsalBR WIWLA---------LGTALMGLGTLYFLVKGMGDPDAKKFYAITTLVPAIAFT-----------MYLSMLLGYWARYADWLFTTPLLLLDLALLVQGTILALVGADGIMIGTGLVGAYSYRFVWWAISTAAMLYILYVLFFGFTPEVA-STFKVLRNVTVVLWSAYPVVWLIG-----SPLNIETLLFMVLDVSAKVGF-GLIL MSP43 AITAGGFGSQPFILAYIITAMISGLLFLYLPRKLDVPQKFGIIHFFIVVWSGL-----------MYTNF-LNDYAWYMDWMVSTPLILLALGLTAYDLLGALLGAEFTLVITGLLAQGSI--TPYYVGVLLLLGVVYLLAKPFRDGLA-RAYKILAGYIGIFFLSYPTVWYISGIDALPDPTQTSIALVVLPFFCKQVY-GFLD CV1 --------------------------------------PWRFTNSPLVVWSGL-----------MYTNF-LNDYAWYMDWMVSTPLILLALGLTAYDLLGALLGAEFTLVVTGLIAQGSI--TPYYVGVLLLLGVVYLLAKPFRDGLA-RAYKLLAGYIGIFFLSYPTVWYISGIDALPDPTQTSIALVVLPF----------- CV2 -----------------------------------------------VVWSGL-----------MYTNF-LSDYAWYMDWMVSTPLILLALGLTAYDLLGALLGAEFTLVVTGLIAQGSI--TPYYVGVLLLLGVVYLLAKPFRDGLA-RAYKLLAGYIGIFFLSYPTVWYISGIDALPDPTQTSIALVVLPF----------- MSP56 AIAGG--ASIPWIQAYIVTAMLSSLAFLYLPKKLNVPQKFGIIHFFIVVWSGL-----------MYTNF-LNDFAWYMDWMVSTPLILLALGLTAYDLLGALLGLEFTLVITGLLAQGSI--YPYYIGVILLLGVVYLLAGPFREGLA-RAYKLLAGYIGIFFLSYPTVWYISSIDALPGPTQTSIALVVLPFFCKQVY-GFLD Cyano DIFHW---------IYVLGMVIGA-FHFWSLSRRGVPQYEYLIAIFIPIWSGL-----------AYMAMALNHYARYVDWIVTTPLLLLALSWTAWTLIGFLMSTQVVVITTGLIADESVRYLWYICGVVAFLIVLWGIWGPLRRDLI-VLYNKLLIYFTVLWVCYPLVWIIG-----PNQTTDTFLFCLLPFFSKVGF-SFLD Nost SLLHW---------IYVAGMTIGA-LHFWSLSRRGVPQYEYLVAMFIPIWSGL-----------AYMAMAIDHYARYIDWMVTTPLLLLSLSWTAWTLIGFLMSTQIVVITSGLIADDWVRYLWYICGVCAFLIILWGIWNPLRSELA-NLYDKLVTYFTVLWIGYPIVWIIG-----PNQTIDTFLFCLLPFFSKVGF-SFLD Hroseo TTLYT---------IYIVCMLLGAFLFLYWGLSRGVPRAEYLVAFLIPVWSAT-----------AYFALSTGHFARYLDWIVTTPLLLFALASTARVIIGGLVLADVFMILTGLIADGSVRWVWYGLGVIAFLGILWTLWGPLRPELA-SVYNRALSFLTILWIAYPLIWALG-----PGPFTEKLLFVVVPILSKVGF-SIVD Bcoah SILHY---------GYSFIMLLGA-LYFYLLSKKGVPASEYLIAMVIPLWSGA-----------AYLSIALGYYARYIDWVISTPLLLAALALTALTLLFSLVALDVFMIITGFVADGTTKYIWYSLGVIALIIILVITFGPLRTRLA-RHYTRVAIYLSVLWVCYPTAWLLG-----PQELTEVLVFIILPIFSKVGF-SIVD HmarBR GIWLW---------LGTAGMFLGMLYFIARGWGDGRRQKFYIATILITAIAFV-----------NYLAMALGYWARYTDWLFTTPLLLYDLGLLARNTIYSLVSLDVLMIGTGVVATGAERLVWWGISTAFLLVLLYFLFSSLSSDTR-STFKTLRNLVTVVWLVYPVWWLVG-----SGIGIETAGFMVIDLVAKVGF-GIIL HvallisBR AIWLW---------LGTAGMFLGMLYFIARGWGDSRRQKFYIATILITAIAFV-----------NYLAMALGYWARYSDWLFTTPLLLYDLGLLARNTISSLVSLDVLMIGTGLVATGAERLVWWGISTAFLLVLLYFLFSSLSSDTR-STFKTLRNLVTVVWLVYPVWWLVG-----TGIGIETAGFMVIDLVAKVGF-GIIL HmarBRII GIWLA---------LGTVGMLLGMVYFMAKGWDDPEQEEFYVITILIAGIAAS-----------SYLSMFFGYWARYADWLFTTPLLLLDIGLLANRDMASLITIDAFMIVTGLAATPVARYAFWTISTIAMLFVLYYLVVVVGEEAQ-STFNVLRNIILVAWAIYPVAWLVG-----TGLFGETLLFMILDLTAKIGF-GFIL HwalBOPI GIWLA---------LGTIGMLLGMLYFIADGLDDPRQKEFYVITILIPAIAAA-----------SYLSMFFGYWARYADWLFTTPLLLLDIGLLAQRDIGALVGIDAFMIVTGLVATVVARYAFWTISTISMVFLLYYLVAVFGEDTR-STFNALRNIILVTWAIYPVAWLVG-----TGLYGETLLFMVLDLVAKVGF-GFIL HwalBOPII ATWLW---------IGTIGMVLGTVYFAVRGRGDPEQQTYYIITTLIPAIAAA-----------AYLAMATGYWARYADWLLTTPLLIIDLALVAKQTLYKLIIIDAIMILGGLAGSAVIRIVWWAVSTAAFIILLYYLLGELSAETG-IVFNRLRNITLGLWALYPIVWILG-----TAVTTEIMLYVMLDIGTKIGF-GAVL HsalSRII TTWFW---------VGAVGMLAGTV---LPIRDHPSHRRYDLVLAGITGLAAI-----------AYTTMGLGYLARYIDWLVTTPLIVLYLAMLAHRTSAWLLAADVFVIAAGIAAAGVQRWLFFAVGAAGYAALLYGLLGTLPPRVR-SLFVTLRNITVVLWTLYPVVWLLS-----PQTEMYTIVVVYLDFISKVAFVAFAV NpharSRII TTLFW---------LGAIGMLVGTLAFAWAGRDGSGERRYYVTLVGISGIAAV-----------AYAVMALGFVPRYIDWILTTPLIVYFLGLLASREFGIVITLNTVVMLAGFAGAGIERYALFGMGAVAFIGLVYYLVGPMTSGIK-SLYVRLRNLTVVLWAIYPFIWLLG-----PTPTVDVALIVYLDLVTKVGF-GFIA HmarSRII TTWFT---------LGLLGELLGTAVLAYGYTLPEETRKRYLLLIAIPGIAIV-----------AYALMALGYVVRYVDWLLTTPLNVWFLALLAREDTVKLVVLQALTIVFGFAGASPVSYALFAVGGALFGGVIYLLYRNIASDIEVSLYRTLRNFVVVLWLVYPVVWLLG-----ADVETATLVVVYLDVVTKVGF-GVIA HvallisSRI TTWFT---------LGLLGELLGTAVLAYGYTLPEETRKRYLLLIAIPGIAIV-----------AYALMALGYVVRYVDWLLTTPLNVWFLALLAREDTVKLVVLQALTIVFGFAGASPVSYALFAVGGALFGGVIYLLYRNIASDIEVSLYRTLRNFVVVLWLVYPVVWLLG-----ADVETATLVVVYLDVVTKVGF-GVIA HmarSRM IVWYG---------AGAGAFFVSAVVFVW--FAGNIRSSFYYLPPIHTSVAGA-----------AYVAMALITTLRFADWIVSTPIITYYLARLATQTRRLAVAANVVMIGVGYGFVGSLRWIAFAVSTVAFIGLLYLYIKTFAASVR-SLFQSLRDLTVVTWSLYPVVYFLG-----PQAPDLNFLVAVLDTIAKVGFMSILL HsalSRI ATAYL---------GGAVALIVGVAFVWLLYRSGSPHQSALAPLAIIPVFAGL-----------SYVGMAYDVGLRYIDWLVTTPILVGYVGYAARRSIIGVMVADALMIAVGAGAVGTLKWALFGVSSIFHLSLFAYLYVIFP-EQI-GLFNLLKNHIGLLWLAYPLVWLFG-----PTAAGVALTYVFLDVLAKVPY-VYFF HmarSRI SVVYG---------ITAAGFAVGVAIVGFLYASGSDERPILAALALIPGVAGI-----------SYVAMVFGVGFRYLDWVVTTPLLVGFIGYTARRAIFGVMAADALMILAGVGAVGTLKWALFGVSAVFHISLFAYLYLIFP-QRI-GLFSLLKNHVGLLWIAYPLVWLAG-----PTYVGVSITYAFLDLLAKVPY-VYFF HvallisSR AVVYG---------ITAAGFAVGVAIVGYLYASGSEERSILAALALIPGFAGI-----------SYVAMAFGVGFRYLDWVVTTPLLVGFVGYAARRAIFGVMVADALMILTGVGAVGTLKWVLFGVSTVFHVSLFAYLYLVFP-QRI-GLFSLLKNHIGLLWIAYPLVWLAG-----PTYVGVSITYAFLDLLAKVPY-VYFF SruberSRI TIVYI---------IGTLGMLVGIPPA----LSGDEVGLDFDYVWAIPGIAAF-----------MYLLMTFDPIPRYIDWALTTPLLVGYTAYIARGMIAGTALADFMMIVFGLGAVSTAQWVFFGLSSACHLTLLALLYGPVRPSHR-RLARLLLNYVGLLWLAYPLVWLFG-----PDAAGIAVIISYLDVTAKVPF-VYFI SruberSRI2 TIVLM---------LGTAGMLFGIPPC----LRDMEADGHFGYLLLIPGFAAL-----------MYALMTFGPLLRYLDWLVTTPIMIGYAAYVAKRGIVGAALVDAVMIGLGTAAVPPTQWIFFGLAALCHLVLLGALYGPIRSTRQ-RLARLLVNHTGLLWITYPVVWVFG-----PSATGVSIMIMYMDVLAKVPF-VYFV HsalHR SLWVN---------VALAGIAI--LVFVYMGRTPGRPRLIWGATLMIPLVSIS-----------SYLGLLSGQWGRYLTWALSTPMILLALGLLALGSLFTVIAADIGMCVTGLAAALLFRWAFYAISCAFFVVVLSALVTDWATA---EIFDTLRVLTVVLWLGYPIVWAVG-----VSVGVTSWAYSVLDVFAKYVF-AFIL HwalHR SLWVN---------IALAGLSI--LLFVYMGRNSGRARLIWGATLMIPLVSIS-----------SYLGLASGQWGRYLTWALSTPMILLALGVLARGSLFTVIAADIGMCVTGLGAAYLFRWAFYIISCTFFVVVLFALLFEWPTD---DIFSTLRLLTVVLWIGYPVIWAAG-----VSVGLTSWGYSGLDILAKYAF-SFLL HmarHR SIWVN---------IALAGVVI--LLFVAMGRDSPRAKLIWVATMLVPLVSIS-----------SYAGLASGPWGRYLTWTFSTPMILLALGLLAIASLFTAITMDIGMCVTGLAAAHLLRWVFYGISCAFFVAVLYVLLVQWPTS---EIFGTLKILTVVLWLGYPILWALG-----SSVGVTSWGYSGLDILAKYVF-AFLL HvallisHR SLWVN---------IALAGVVI--LLFVAMGRESSRAKLIWVATMLVPLVSIS-----------SYAGLASGPWGRYLTWTFSTPMILLALGLLAMASLFTAITMDIGMCITGLAAAHLLRWVFYGISCAFFIAVLYVLLVEWPTS---EIFGTLKLLTVVLWLGYPILWALG-----SSVGVTSWGYSGLDILAKYVF-AFLL NpharHR SLYIN---------IALAGLSI--LLFVFMTRGDPRAKLIAVSTILVPVVSIA-----------SYTGLASGMWGRYLTWALSTPMILLALGLLAATKLFTAITFDIAMCVTGLAAAHLMRWFWYAISCACFIVVLYILLVEWATA---DIFSTLKLLTVVMWLGYPIVWALG-----VPVGYTSWAYSALDIVAKYIF-AFLL SruberHR SIYVN---------IALAGLTI--IVIAVMSRSDSRAKLITMSTLMISVVSIS-----------SYMGLASGLWGRYLTWAFSTPFILLALGLLATDKIFSAIVLDVFMCLTGLAAAHAMRWLWYALSTAFFVGVLYYLLVEWPTA---DIFSTLQWMTIVLWIGYPVVWALG-----NEVGATSWAYSGLDIFAKYAF-TIIL PelubiqBOP GISFW---------LVSMALLASTAFFFIERASPAGWRVSITVAGLVTGIAFI-----------HYMYMRDVTVYRYIDWLITVPLLMLEFYFVLSGIFWRLMIGTLVMLIGGYLGE--------VIGMAGWFYILYEVFSGEAKALV-TAFGAMRMIVTVGWAIYPLGYVFG------ASSL-NVIYNAADFLNKIAF-GLII EsibiriBOP ---FW---------VGFVGMAAGTLYFLVERNSAPEYRSTATVAALVTFVAAI-----------HYYFMKDATEIRYIDWLVTTPLLLVKFPLLLRPLLTKLVIADVIMIVGGYIGETQLGLWSYLIGCFAWIYIIYLLFTNVTAPIR-DALLKMRLFILIGWAIYPIGYAVT------IQLVRELIYNFADLTNKVGF-GLIA HroseoR2 THVLT---------LGVGAQIAGLIYFVLTRKNAPRYQLSSVLSAVVMVSAALILLNQQINWTSAFTWDGQMNGYRYVNWSIDVPMLLTQLLIVLKKIWLGFTLGGLAMIYTGYVGQPNLLIWGGISSVF-MVYICYLVGTTIFGTTG-GLMRNIFWLLIFSWTLYPIAYLVP------GMVLRQVLYTVADITSKVIY-GVML