"Additional file 9. Differentially expressed genes associated with WNT pathway, cell adhesion or calcium. Columns ‘CHEK2 M’ and ‘other M' give average and range of expression values for each gene in CHEK2 1100delC mutation carrier and other tumor samples correspondingly. ",,,,,,,
,,,,,,,
Gene Symbol,Annotations,,,Fold change,p-value,CHEK2 M (min-max),other M (min-max)
WNT2,WNT-pathway,Focal adhesion,,1.2741,0.0093,1.20 ((0.29) - (1.96)),0.84 ((0.10) - (2.34))
DVL3,WNT-pathway,,,1.1412,0.0143,-0.14 ((-0.51) - (0.18)),-0.30 ((-0.97) - (0.41))
NKD2,WNT-pathway,,Calcium binding,1.1951,0.028,-0.15 ((-0.88) - (0.81)),-0.40 ((-1.1) - (0.92))
CAMK2G,WNT-pathway,,Calcium binding,1.1442,0.0147,0.51 ((-0.03) - (0.75)),0.29 ((-0.45) - (0.82))
NFAT5,WNT-pathway,,,1.1126,0.0487,-0.23 ((-0.78) - (0.26)),-0.29 ((-0.78) - (0.32))
PPP3R1,WNT-pathway,,Calcium binding,1.1698,0.0162,-0.07 ((-0.72) - (0.76)),-0.26 ((-0.97) - (0.74))
MYC,WNT-pathway,,,1.2443,0.0028,0.78 ((-0.15) - (1.55)),0.50 ((-0.21) - (1.14))
CALCOCO1,WNT-pathway,,Calcium binding,1.2579,0.0016,1.06 ((0.55) - (1.59)),0.72 ((-0.11) - (1.52))
STK11,WNT-pathway,,,1.175,0.018,0.17 ((-0.27) - (0.74)),-0.07 ((-0.83) - (0.76))
FAM123B,WNT-pathway,,,1.1046,0.0383,-0.18 ((-0.53) - (0.02)),-0.26 ((-0.98) - (0.41))
LRP1,WNT-pathway,,,0.817,0.0011,-0.02 ((-0.6) - (0.39)),0.16 ((-0.59) - (0.86))
LEF1,WNT-pathway,,,0.7088,0.0081,-1.33 ((-2.25) - (-0.4)),-1.12 ((-2.50) - (0.40))
"GSK3A [106, 107]",WNT-pathway,,,1.1653,0.0166,0.21 ((-0.46) - (0.8)),0.05 ((-0.61) - (0.66))
CTNND1,WNT-pathway,Focal adhesion,,1.2881,0.0084,0.68 ((0.13) - (2.08)),0.41 ((-0.34) - (1.7))
MFRP [108],WNT-pathway,,,1.1769,0.0415,1.02 ((0.34) - (1.75)),0.82 ((0.02) - (1.89))
CDH1,,Focal adhesion,Calcium binding,1.6706,0.0006,0.65 ((-0.84) - (2.03)),0.15 ((-0.96) - (1.99))
PARVB,,Focal adhesion,,1.1773,0.0378,0.15 ((-0.45) - (1.11)),0.00 ((-0.70) - (0.86))
TES,,Focal adhesion,,1.2268,0.0151,0.48 ((-0.20) - (1.21)),0.35 ((-0.86) - (1.55))
GAK,,Focal adhesion,,1.139,0.0283,0.34 ((-0.14) - (0.70)),0.11 ((-0.71) - (0.71))
VCL,,Focal adhesion,,1.1765,0.036,0.17 ((-0.29) - (0.93)),-0.02 ((-0.71) - (0.84))
ZNF384,,Focal adhesion,,0.8759,0.0318,-0.53 ((-1.03) - (-0.19)),-0.39 ((-1.11) - (0.37))
CD2,,Cell adhesion,,0.8386,0.0435,0.30 ((-0.18) - (0.97)),0.54 ((-0.31) - (1.63))
CLDN14,,Cell adhesion,,1.1009,0.0257,-0.04 ((-0.41) - (0.21)),-0.12 ((-0.94) - (0.47))
JAM3,,Cell adhesion,,1.2286,0.0137,0.17 ((-0.26) - (0.73)),-0.14 ((-1.02) - (0.95))
SDC3,,Cell adhesion,,1.2895,0.0155,0.65 ((-0.15) - (1.57)),0.34 ((-0.53) - (1.25))
CNTN1,,Cell adhesion,,1.3699,0.0132,0.93 ((-0.07) - (3.02)),0.65 ((-0.05) - (1.82))
CHM,,Cell adhesion,,0.9115,0.0432,-0.12 ((-0.36) - (0.20)),0.04 ((-0.33) - (1.00))
LALBA,,,Calcium binding,1.2368,0.0187,-0.19 ((-2.62) - (0.87)),0.03 ((-0.69) - (6.38))
MEGF8,,,Calcium binding,1.2064,0.0417,0.10 ((-0.66) - (1.59)),-0.20 ((-1.87) - (1.56))
S100A8,,,Calcium binding,1.2438,0.0363,1.00 ((-0.12) - (2.21)),0.75 ((-0.07) - (1.98))
UTRN,,,Calcium binding,1.162,0.0093,0.58 ((-0.03) - (1.34)),0.45 ((-0.11) - (1.17))
MAN1B1,,,Calcium binding,1.1786,0.0506,0.14 ((-0.29) - (0.51)),-0.03 ((-0.89) - (0.94))
CRNN,,,Calcium binding,1.157,0.009,0.42 ((-0.42) - (0.83)),0.42 ((-0.40) - (1.30))
PLCL2,,,Calcium binding,1.1155,0.0195,0.21 ((-0.30) - (0.91)),0.13 ((-0.37) - (0.76))
PRRG3,,,Calcium binding,1.2408,0.0419,0.08 ((-0.36) - (1.46)),0.07 ((-0.46) - (2.78))
FGG,,,Calcium binding,1.2513,0.0201,-1.81 ((-2.53) - (-1.11)),-1.94 ((-2.88) - (-0.61))
RASGRP4,,,Calcium binding,1.1057,0.047,-0.10 ((-0.52) - (0.67)),-0.17 ((-1.53) - (0.34))
SYN3,,,Calcium binding,1.228,0.029,0.74 ((-0.08) - (2.21)),0.65 ((-0.29) - (1.84))
PLA2G12B,,,Calcium binding,1.1232,0.0494,0.33 ((-0.64) - (0.7)),0.24 ((-0.66) - (0.81))
OIT3,,,Calcium binding,1.1618,0.0165,0.87 ((0.24) - (1.26)),0.66 ((0.05) - (1.35))
THBS1,,,Calcium binding,1.5851,0.0099,2.18 ((0.55) - (4.66)),1.62 ((0.20) - (3.57))
ENTPD2,,,Calcium binding,1.1965,0.0409,0.37 ((-0.40) - (0.92)),0.24 ((-0.53) - (1.83))
S100A2,,,Calcium binding,1.4163,0.0312,0.69 ((-0.18) - (3.38)),0.29 ((-0.45) - (2.93))
PCDHB9,,,Calcium binding,1.2529,0.0135,0.38 ((-0.39) - (1.16)),0.32 ((-2.78) - (4.29))
CLCA1,,,Calcium binding,1.8178,0,1.05 ((-0.52) - (3.88)),0.38 ((-0.71) - (1.70))
DLL1,,,Calcium binding,1.1327,0.0514,0.34 ((-0.10) - (1.10)),0.30 ((-0.11) - (1.35))
MMP10,,,Calcium binding,1.1831,0.0422,-0.68 ((-1.45) - (0.02)),-0.86 ((-1.89) - (0.00))
BNIP2,,,Calcium binding,1.1335,0.0427,0.07 ((-0.45) - (0.72)),-0.02 ((-0.70) - (0.57))
ITGA7,,,Calcium binding,1.2531,0.0201,0.74 ((0.02) - (1.84)),0.54 ((-0.39) - (1.88))
PLA2G3,,,Calcium binding,1.3436,0.0103,0.12 ((-0.38) - (1.49)),-0.01 ((-1.71) - (3.23))
MEGF6,,,Calcium binding,1.3248,0.008,0.33 ((-0.54) - (1.95)),0.00 ((-0.82) - (2.47))
PLA2G2D,,,Calcium binding,3.7976,0.0012,0.61 ((-1.55) - (3.87)),0.35 ((-2.15) - (3.31))
TLL1,,,Calcium binding,1.1843,0.0305,-0.02 ((-4.14) - (2.09)),0.09 ((-2.62) - (0.54))