Table 3. Striatal MPP+ levels

Mice

90 min

180 min

WT

8.9 ± 0.6

7.7 ± 2.0

Jnk2

–/–

10.3 ± 2.0

6.6 ± 0.5

Jnk3

–/–

6.7 ± 1.6

5.2 ± 1.4

Jnk2

/3–/–

6.5 ± 0.8

8.1 ± 0.8

Targeted disruption of Jnk genes in mice does not alter brain metabolism of 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine. Values, in units of m g/g striatum, represent mean ± SEM for three to four mice per group. MPP+, 1-methyl-4-phenylpyridinium ion; WT, wild type.