Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens

Supplemental Materials

This article contains the following supporting material:

• Supplemental Materials
• Movie01 - Video 1: Time-lapse images of EGFR-mCherry-expressing cells invading surrounding brain. Images were captured every 3 minutes and displayed at a rate of 30 frames per second.
• Movie02 - Video 2: Time lapse of EGFR-mCherry-expressing cells in the presence of 0.1 ng/ml EGF. Video conditions as above.
• Movie03 - Video 3: Time lapse of EGFR-mCherry-expressing cells in the presence of 0.1 ng/ml EGF+ 100 ng/ml PDGF.
• Movie04 - Video 4: Time lapse of EGFR-mCherry-expressing cells in the presence of 0.1 ng/ml EGF+10�M Iressa.
• Movie05 - Video 5: Time lapse of EGFR-mCherry-expressing cells in the presence of 0.1 ng/ml EGF+20�M blebbistatin.
• Movie06 - Video 6: Time lapse of EGFR-mCherry-expressing cells in the presence of 0.1 ng/ml EGF+100 ng/ml PDGF+10�M Iressa.
• Movie07 - Video 7: Time lapse of EGFR-mCherry-expressing cells in the presence of 0.1 ng/ml EGF+100 ng/ml PDGF+20�M blebbistatin.
• Movie08 - Video 8: Two color video of EGFR(+) cells (red) and PDGF secreting cells (green). No added ligands ("Baseline").
• Movie09 - Video 9: In the presence of 0.1 ng/ml EGF.
• Movie10 - Video 10: In the presence of 0.1 ng/ml EGF+10�M Iressa.
• Movie11 - Video 11: In the presence of 0.1 ng/ml EGF+20�M blebbistatin.