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. Author manuscript; available in PMC: 2013 Jan 18.
Published in final edited form as: ACS Chem Neurosci. 2012 Jan 18;3(1):5–11. doi: 10.1021/cn200085z

Figure 3.

Figure 3

Figure 3

Acute treatment of primary cortical neurons with BIP-135 protects from oxidative stress. Graphs showing the survival of cortical neurons upon exposure to the GSK-3 inhibitors, (A) BIP-135, (B) AR-A011418, or (C) SB-216763, in the absence (blue bar) or presence (red bar) of HCA (5 mM) after 48 h, using the MTT assay. Data are presented as percent of control ± SEM. (D) Representative micrographs showing live/dead staining of primary cortical neurons after 48 h incubation with BIP-135 (c,d), AR-A011418 (e,f), or SB-216763 (g,h) in the absence (a, c, e, g) or presence (b, d, f, h) of HCA (5 mM). Live and dead neurons were stained with calcein AM (green fluorescence) and ethidium homodimer (red fluorescence), respectively. The control contains no GSK-3 inhibitors.