Identification of a Cryptococcus neoformans Cytochrome P450 Lanosterol 14α-Demethylase (Erg11) Residue Critical for Differential Susceptibility between Fluconazole/Voriconazole and Itraconazole/Posaconazole

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 - Additional experimental details.
  MS Word document, 53K.
• Supplemental file 2 - Figure S1, alignment of ERG11 sequences.
  TIFF file, 1.7MB.
• Supplemental file 3 - Figure S2, energy minimized homology model of C. neoformans lanosterol 14alpha-demethylase (Erg11) with bound heme and eburicol.
  TIFF file, 251K.
• Supplemental file 4 - Figure S3, GC-MS analysis of the sterol profile.
  TIFF file, 324K.