ENT1, a Ribavirin Transporter, Plays a Pivotal Role in Antiviral Efficacy of Ribavirin in a Hepatitis C Virus Replication Cell System

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 - Figure S1, effects of hypoxanthine and formycin B on ENT2 activity.
  PDF file, 196K.
• Supplemental file 10 - Additional experimental details.
  PDF file, 205K.
• Supplemental file 2 - Figure S2, effects of ribavirin and NBMPR on ENT1 protein expression in OR6 cells and cell viability.
  PDF file, 536K.
• Supplemental file 3 - Figure S3, effects of NBMPR or ENT1 knockdown on ribavirin antiviral activity in OR6 cells.
  PDF file, 251K.
• Supplemental file 4 - Figure S4, effects of hypoxanthine, formycin B, and NBMPR on ribavirin antiviral activity.
  PDF file, 244K.
• Supplemental file 5 - Figure S5, effect of NBMPR on telaprevir antiviral activity in OR6 cells.
  PDF file, 169K.
• Supplemental file 6 - Figure S6, effect of NBMPR on ribavirin antiviral activity in OR6 cells.
  PDF file, 218K.
• Supplemental file 7 - Figure S7, illustration of the model showing potential contribution of ENT1-mediated ribavirin uptake to treatment response individuality in anti-HCV therapy.
  PDF file, 143K.
• Supplemental file 8 - Table S1, oligonucleotide sequences.
  PDF file, 212K.
• Supplemental file 9 - Table S2, cytotoxic analyses of ribavirin and ENT inhibitors on OR6 cells.
  PDF file, 191K.