List of proteins possibly mediating the dormancy signals between up and down-regulated modules during dormancy. Upregulated Rv2004c Rv2004c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv1309 atpG IntermediaryMandRespiration PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG Intermediate Rv1311 atpC IntermediaryMandRespiration PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC Upregulated Rv3133c devR RegulatoryProteins TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY) Upregulated Rv2029c pfkB IntermediaryMandRespiration Probable phosphofructokinase PfkB (PHOSPHOHEXOKINASE) Downregulared Rv1614 lgt CellwallandCellprocesses Possible prolipoprotein diacylglyceryl transferases Lgt Intermediate Rv2334 cysK1 IntermediaryMandRespiration PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) Upregulated Rv3127 Rv3127 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Downregulared Rv1310 atpD IntermediaryMandRespiration PROBABLE ATP SYNTHASE BETA CHAIN ATPD Intermediate Rv3775 lipE IntermediaryMandRespiration PROBABLE LIPASE LIPE Intermediate Rv1274 lprB CellwallandCellprocesses POSSIBLE LIPOPROTEIN LPRB Intermediate Rv0434 Rv0434 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Upregulated Rv2626c Rv2626c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv0464c Rv0464c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv2890c rpsB InformationPathways PROBABLE 30S RIBOSOMAL PROTEIN S2 RPSB Intermediate Rv1157c Rv1157c ConservedHypotheticals CONSERVED HYPOTHETICAL ALA-, PRO-RICH PROTEIN Intermediate Rv0014c pknB RegulatoryProteins TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE B PKNB (PROTEIN KINASE B) (STPK B) Downregulared Rv3156 nuoL IntermediaryMandRespiration PROBABLE NADH DEHYDROGENASE I (CHAIN L) NUOL (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN L) Intermediate Rv1018c glmU CellwallandCellprocesses Probable UDP-N-acetylglucosamine pyrophosphorylase glmU Upregulated Rv2629 Rv2629 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Downregulared Rv3153 nuoI IntermediaryMandRespiration PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN I) Upregulated Rv0082 Rv0082 IntermediaryMandRespiration PROBABLE OXIDOREDUCTASE Intermediate Rv2861c mapB IntermediaryMandRespiration PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) Intermediate Rv2244 acpP LipidMetabolism MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM Intermediate Rv3100c smpB Virulence Detoxification Adaptation PROBABLE SSRA-BINDING PROTEIN SMPB Intermediate Rv3125c PPE49 PEPPE PPE FAMILY PROTEIN Upregulated Rv1997 ctpF CellwallandCellprocesses PROBABLE METAL CATION TRANSPORTER P-TYPE ATPASE A CTPF Downregulared Rv1547 Intermediate Rv0896 gltA IntermediaryMandRespiration PROBABLE CITRATE SYNTHASE I GLTA2 Intermediate Rv1166 lpqW CellwallandCellprocesses PROBABLE CONSERVED LIPOPROTEIN LPQW Intermediate Rv1162 narH IntermediaryMandRespiration PROBABLE RESPIRATORY NITRATE REDUCTASE (BETA CHAIN) NARH Upregulated Rv2031c hspX Virulence Detoxification Adaptation HEAT SHOCK PROTEIN HSPX (ALPHA-CRYSTALLIN HOMOLOG) (14 kDa ANTIGEN) (HSP16.3) Intermediate Rv3019c esxR CellwallandCellprocesses SECRETED ESAT-6 LIKE PROTEIN ESXR (TB10.3) (ESAT-6 LIKE PROTEIN 9) Downregulared Rv3148 nuoD IntermediaryMandRespiration PROBABLE NADH DEHYDROGENASE I (CHAIN D) NUOD (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN D) Intermediate Rv3910 Rv3910 CellwallandCellprocesses PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Intermediate Rv2465c Rv2465c IntermediaryMandRespiration RIBOSE-5-PHOSPHATE ISOMERASE Intermediate Rv2428 ahpC Virulence Detoxification Adaptation ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C) Intermediate Rv3913 trxB2 IntermediaryMandRespiration PROBABLE THIOREDOXIN REDUCTASE TRXB2 (TRXR) (TR) Intermediate Rv0479c Rv0479c CellwallandCellprocesses PROBABLE CONSERVED MEMBRANE PROTEIN Intermediate Rv1111c Rv1111c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv1080c greA InformationPathways PROBABLE TRANSCRIPTION ELONGATION FACTOR GREA (Transcript cleavage factor greA) Intermediate Rv0814c sseC2 IntermediaryMandRespiration CONSERVED HYPOTHETICAL PROTEIN SSEC2 Intermediate Rv3402c Rv3402c CellwallandCellprocesses CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv1630 rpsA InformationPathways PROBABLE RIBOSOMAL PROTEIN S1 RPSA Intermediate Rv1709 Rv1709 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv3265c wbbL1 CellwallandCellprocesses PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WBBL1 (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENYL) Intermediate Rv3158 nuoN IntermediaryMandRespiration PROBABLE NADH DEHYDROGENASE I (CHAIN N) NUON (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN N) Intermediate Rv0573c Rv0573c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Upregulated Rv0080 Rv0080 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv2343c dnaG InformationPathways PROBABLE DNA PRIMASE DNAG Intermediate Rv2882c frr InformationPathways RIBOSOME RECYCLING FACTOR FRR (RIBOSOME RELEASING FACTOR) (RRF) Upregulated Rv2005c Rv2005c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv3709c ask IntermediaryMandRespiration ASPARTOKINASE ASK (ASPARTATE KINASE) [CONTAINS: ASPARTOKINASE ALPHA SUBUNIT (ASK-ALPHA); AND ASPARTOKINASE BETA SUBUNIT (ASK-BETA)] Intermediate Rv1312 Rv1312 CellwallandCellprocesses CONSERVED HYPOTHETICAL SECRETED PROTEIN Intermediate Rv2150c ftsZ CellwallandCellprocesses cell division protein FtsZ Upregulated Rv3131 Rv3131 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv2621c Rv2621c RegulatoryProteins POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN Downregulared Rv1613 trpA IntermediaryMandRespiration Probable tryptophan synthase, alpha subunit trpA Intermediate Rv2108 PPE36 PEPPE PPE FAMILY PROTEIN Intermediate Rv3048c nrdF InformationPathways RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF2 (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) Upregulated Rv2030c Rv2030c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Upregulated Rv2028c Rv2028c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv3207c Rv3207c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Upregulated Rv0081 Rv0081 RegulatoryProteins PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN Intermediate Rv0451c mmpS4 CellwallandCellprocesses PROBABLE CONSERVED MEMBRANE PROTEIN MMPS4 Intermediate Rv0009 ppiA InformationPathways PROBABLE IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA (PPIase A) (ROTAMASE A) Intermediate Rv1300 hemK IntermediaryMandRespiration PROBABLE HEMK PROTEIN HOMOLOG HEMK Upregulated Rv1996 Rv1996 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Upregulated Rv3129 Rv3129 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv1307 atpH IntermediaryMandRespiration PROBABLE ATP SYNTHASE DELTA CHAIN ATPH Intermediate Rv3149 nuoE IntermediaryMandRespiration PROBABLE NADH DEHYDROGENASE I (CHAIN E) NUOE (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN E) Intermediate Rv1737c narK2 CellwallandCellprocesses POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 Intermediate Rv0167 yrbE1A Virulence Detoxification Adaptation CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE1A Intermediate Rv2681 Rv2681 ConservedHypotheticals CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN Intermediate Rv2948c fadD22 LipidMetabolism PROBABLE FATTY-ACID-CoA LIGASE FADD22 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Upregulated Rv2625c Rv2625c CellwallandCellprocesses PROBABLE CONSERVED TRANSMEMBRANE ALANINE AND LEUCINE RICH PROTEIN Downregulared Rv3154 nuoJ IntermediaryMandRespiration PROBABLE NADH DEHYDROGENASE I (CHAIN J) NUOJ (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN J) Intermediate Rv1343c lprD CellwallandCellprocesses PROBABLE CONSERVED LIPOPROTEIN LPRD Intermediate Rv3099c Rv3099c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv3458c rpsD InformationPathways PROBABLE 30S RIBOSOMAL PROTEIN S4 RPSD Intermediate Rv0170 mce1B Virulence Detoxification Adaptation MCE-FAMILY PROTEIN MCE1B Intermediate Rv0164 TB18.5 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN TB18.5 Upregulated Rv0569 Rv0569 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv3234c Rv3234c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN. POSSIBLE TRIACYLGLYCEROL SYNTHASE (DIACYLGLYCEROL ACYLTRANSFERASE). Upregulated Rv2003c Rv2003c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv1438 tpiA IntermediaryMandRespiration PROBABLE TRIOSEPHOSPHATE ISOMERASE TPI (TIM) Intermediate Rv0844c narL RegulatoryProteins POSSIBLE NITRATE/NITRITE RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN NARL Intermediate Rv1163 narJ IntermediaryMandRespiration PROBABLE RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) NARJ Intermediate Rv1302 rfe CellwallandCellprocesses PROBABLE UNDECAPAPRENYL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMINYLTRANSFERASE RFE (UDP-GlcNAc TRANSFERASE) Downregulared Rv0173 lprK CellwallandCellprocesses POSSIBLE MCE-FAMILY LIPOPROTEIN LPRK (MCE-FAMILY LIPOPROTEIN MCE1E) Intermediate Rv1632c Rv1632c ConservedHypotheticals HYPOTHETICAL PROTEIN Intermediate Rv0724 sppA CellwallandCellprocesses POSSIBLE PROTEASE IV SPPA (ENDOPEPTIDASE IV) (SIGNAL PEPTIDE PEPTIDASE) Intermediate Rv1707 Rv1707 CellwallandCellprocesses PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Intermediate Rv1626 Rv1626 RegulatoryProteins Probable two-component system transcriptional regulator Intermediate Rv1565c Rv1565c CellwallandCellprocesses CONSERVED HYPOTHETICAL MEMBRANE PROTEIN Upregulated Rv2627c Rv2627c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv1161 narG IntermediaryMandRespiration PROBABLE RESPIRATORY NITRATE REDUCTASE (ALPHA CHAIN) NARG Intermediate Rv1477 Rv1477 Virulence Detoxification Adaptation Peptidoglycan hydrolase Intermediate Rv0350 dnaK Virulence Detoxification Adaptation PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70) Intermediate Rv2046 lppI CellwallandCellprocesses Probable lipoprotein lppI Upregulated Rv3130c Rv3130c LipidMetabolism Triacylglycerol synthase (Diacylglycerol acyltransferase) Intermediate Rv0721 rpsE InformationPathways PROBABLE 30S RIBOSOMAL PROTEIN S5 RPSE Upregulated Rv3132c devS RegulatoryProteins TWO COMPONENT SENSOR HISTIDINE KINASE DEVS Intermediate Rv1984c cfp21 CellwallandCellprocesses PROBABLE CUTINASE PRECURSOR CFP21 Intermediate Rv3774 echA21 LipidMetabolism POSSIBLE ENOYL-CoA HYDRATASE ECHA21 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE) Intermediate Rv0050 ponA1 CellwallandCellprocesses PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE) Intermediate Rv0169 mce1A Virulence Detoxification Adaptation MCE-FAMILY PROTEIN MCE1A Intermediate Rv1342c Rv1342c CellwallandCellprocesses CONSERVED MEMBRANE PROTEIN Intermediate Rv1280c oppA CellwallandCellprocesses PROBABLE PERIPLASMIC OLIGOPEPTIDE-BINDING LIPOPROTEIN OPPA Downregulared Rv3258c Rv3258c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv3017c esxQ CellwallandCellprocesses ESAT-6 LIKE PROTEIN ESXQ (TB12.9) (ESAT-6 LIKE PROTEIN 8) Intermediate Rv1361c PPE19 PEPPE PPE FAMILY PROTEIN Upregulated Rv2624c Rv2624c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv3199c nudC IntermediaryMandRespiration PROBABLE NADH PYROPHOSPHATASE NUDC (NAD+ DIPHOSPHATASE) (NAD+ PYROPHOSPHATASE) (NADP PYROPHOSPHATASE) Intermediate Rv3232c pvdS InformationPathways POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN PVDS (PROBABLE RNA POLYMERASE SIGMA FACTOR) Intermediate Rv3782 Rv3782 Unknown Galactofuranosyl transferase Downregulared Rv0172 mce1D Virulence Detoxification Adaptation MCE-FAMILY PROTEIN MCE1D Intermediate Rv0684 fusA1 InformationPathways PROBABLE ELONGATION FACTOR G FUSA1 (EF-G) Intermediate Rv1698 Rv1698 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv1631 coaE IntermediaryMandRespiration Probable dephospho-CoA kinase coaE (dephosphocoenzyme A kinase) Intermediate Rv3018c PPE46 PEPPE PPE FAMILY PROTEIN Upregulated Rv2623 TB31.7 ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN TB31.7 Intermediate Rv0683 rpsG InformationPathways PROBABLE 30S RIBOSOMAL PROTEIN S7 RPSG Intermediate Rv0528 Rv0528 CellwallandCellprocesses PROBABLE CONSERVED TRANSMEMBRANE PROTEIN Intermediate Rv0708 rplP InformationPathways PROBABLE 50S RIBOSOMAL PROTEIN L16 RPLP Intermediate Rv3490 otsA Virulence Detoxification Adaptation PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] OTSA (TREHALOSE-6-PHOSPHATE SYNTHASE) (UDP-GLUCOSE-GLUCOSEPHOSPHATE GLUCOSYLTRANSFERASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYLTRANSFERASE) (TREHALOSE-6-PHOSPHATE SYNTHETASE) (TREHALOSE-PHOSPHATE SYNTHASE) (TREHALOSE-PHOSPHATE SYNTHETASE) (TRANSGLUCOSYLASE) (TREHALOSEPHOSPHATE-UDP GLUCOSYL TRANSFERASE) Intermediate Rv2381c mbtD LipidMetabolism POLYKETIDE SYNTHETASE MBTD (POLYKETIDE SYNTHASE) Upregulated Rv2032 acg ConservedHypotheticals Conserved hypothetical protein Acg Downregulared Rv3587c Rv3587c CellwallandCellprocesses PROBABLE CONSERVED MEMBRANE PROTEIN Intermediate Rv3647c Rv3647c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN Intermediate Rv0054 ssb InformationPathways PROBABLE SINGLE-STRAND BINDING PROTEIN SSB (HELIX-DESTABILIZING PROTEIN) Intermediate Rv0685 tuf InformationPathways PROBABLE IRON-REGULATED ELONGATION FACTOR TU TUF (EF-TU) Intermediate Rv3043c ctaD IntermediaryMandRespiration PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) Intermediate Rv2898c Rv2898c ConservedHypotheticals CONSERVED HYPOTHETICAL PROTEIN