Supplementary material for Kayo et al. (April 17, 2001) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.081061898
Table 8.
Caloric restriction-related increases in gene expression in vastus lateralis of rhesus monkeys*ORF | Fold Change With CR | SE | SI CR | SI Control | Gene | Class |
X64559 | 10.3 | 3.4 | 4153 | 70 | Tetranectin | Unknown |
S53175 | 9.0 | 1.2 | 2707 | 0 | NADH-Ubiquinone Oxidoreductase, 51 Kda Subunit | Energy metabolism |
X73039 | 8.5 | 3.9 | 4426 | 723 | Sox 12 | Growth regulatory protein |
Z74616 | 8.2 | 2.8 | 4942 | 591 | Collagen I, alpha 2 | Structural protein |
S81737 | 7.0 | 2.0 | 3309 | 923 | Syntrophin, alpha 1 | Structural protein |
M60832 | 5.8 | 0.9 | 1086 | 0 | Collagen VIII, alpha 2 | Structural protein |
M19878 | 5.4 | 1.8 | 3908 | 979 | Calbindin 1 | Energy metabolism |
U54617 | 5.3 | 3.0 | 2321 | 260 | Pyruvate dehydrogenase kinase isoform 4 | Energy metabolism |
X06700 | 5.1 | 1.7 | 6116 | 1121 | Collagen III, alpha 1 | Structural protein |
M63391 | 5.1 | 1.8 | 57549 | 14742 | Desmin | Structural protein |
U52101 | 4.5 | 1.1 | 1804 | 350 | Epithelial membrane protein 3 | Growth regulatory protein |
M55998 | 4.3 | 1.2 | 48707 | 12855 | Collagen I, alpha 1 | Structural protein |
X90858 | 4.1 | 1.9 | 3310 | 585 | Uridine phosphorylase | DNA metabolism |
D63391 | 4.0 | 1.3 | 2408 | 205 | Platelet activating factor acetylhydrolase IB, gamma | Growth regulatory protein |
X13916 | 4.0 | 0.9 | 1286 | 268 | LDL receptor related protein 1 | Energy metabolism |
U53874 | 3.9 | 0.8 | 1304 | 167 | Blue Cone Photoreceptor Pigment | Structural protein |
X53416 | 3.8 | 2.2 | 992 | 74 | Filamin A, alpha | Structural protein |
X01703 | 3.8 | 0.7 | 4764 | 1848 | Tubulin, alpha, brain-specific | Structural protein |
X62515 | 3.7 | 1.1 | 1046 | 109 | Heparan sulfate proteoglycan 2 | Structural protein |
X02761 | 3.7 | 1.1 | 11557 | 3492 | Fibronectin 1 | Structural protein |
M62831 | 3.6 | 1.0 | 1213 | 87 | Transcription factor ETR101 | Transcription factor |
X99393 | 3.6 | 1.6 | 397 | 92 | Chemokine (C-C motif) receptor 5 | Inflammatory response |
L40394 | 3.6 | 0.4 | 202 | 0 | Regulator of G protein signalling 6 | Signal transduction |
D78156 | 3.5 | 1.7 | 3998 | 311 | RAS p21 protein activator 2 | Signal transduction |
X82207 | 3.5 | 1.5 | 931 | 0 | Centractin, beta | Structural protein |
X80590 | 3.4 | 1.6 | 21221 | 11178 | Phosphorylase kinase, gamma 1 (muscle) | Signal transduction |
D38305 | 3.2 | 1.4 | 20202 | 8682 | Transducer of ERBB2, 1 | Growth regulatory protein |
X56667 | 3.1 | 0.8 | 908 | 71 | Calbindin 2 | Calucium metabolism |
X98248 | 3.1 | 0.6 | 4125 | 1421 | Sortilin 1 | Transport |
X52022 | 3.1 | 0.8 | 4173 | 1789 | Collagen VI, alpha 3 | Structural protein |
X05855 | 3.1 | 1.2 | 5789 | 2368 | H3 histone 3A | Structural protein |
X72012 | 3.0 | 0.7 | 2892 | 970 | Endoglin | Structural protein |
M73780 | 3.0 | 0.4 | 518 | 7 | Integrin, beta 8 | Cell adhesion protein |
X79353 | 2.9 | 1.6 | 4413 | 1300 | GDP dissociation inhibitor 1 | Signal transduction |
M18078 | 2.9 | 1.2 | 1101 | 67 | Statherin | Metabolism |
A15293 | 2.8 | 0.5 | 1682 | 529 | Albumin | Serum protein |
X51362 | 2.8 | 1.4 | 2533 | 711 | Dopamine receptor D2 | Neurotransmission |
Z26653 | 2.8 | 0.6 | 1958 | 716 | Laminin, alpha 2 | Structural protein |
U21128 | 2.8 | 0.6 | 2952 | 1038 | Lumican | Structural protein |
L13698 | 2.8 | 0.7 | 1543 | 469 | Growth arrest-specific 1 | Growth regulatory protein |
M20747 | 2.8 | 0.8 | 5498 | 2656 | GLUT4 | Transport |
D38583 | 2.8 | 0.4 | 1711 | 642 | Calgizzarin | Structural protein |
M80563 | 2.8 | 0.5 | 12621 | 4173 | CAPL | Growth regulatory protein |
X97074 | 2.7 | 1.1 | 2239 | 911 | Clathrin-associated/assembly/adaptor protein, small 2 (17kD) | Transport |
X14474 | 2.7 | 0.8 | 4789 | 2123 | Microtubule-associated tau protein | Structural protein |
X98253 | 2.7 | 0.6 | 4126 | 1675 | Zinc finger protein 183 | Unknown |
M74099 | 2.7 | 0.7 | 3151 | 1195 | Cut (Drosophila)-like 1 | Transcription factor |
Z48512 | 2.7 | 1.1 | 2480 | 440 | Sex-determining region Y (SRY) | Transcription factor |
U62317 | 2.7 | 0.7 | 964 | 293 | Hypothetical protein 384D8_2 gene | Unknown |
M62403 | 2.7 | 1.4 | 3154 | 1109 | Insulin-like growth factor binding protein 4 | Growth regulatory protein |
M19720 | 2.7 | 0.6 | 1373 | 185 | L-myc | Growth regulatory protein |
U18009 | 2.6 | 0.7 | 674 | 1 | Clone LF113 | Unknown |
L43631 | 2.6 | 0.8 | 2192 | 972 | Scaffold attachment factor B | Structural protein |
S80562 | 2.6 | 0.5 | 917 | 190 | Calponin 3, acidic | Structural protein |
X66436 | 2.6 | 0.6 | 4649 | 2881 | Guanine nucleotide binding protein-like 1 | Signal transduction |
D86977 | 2.6 | 0.6 | 1507 | 361 | KIAA0224 | Unknown |
D14446 | 2.6 | 0.6 | 900 | 252 | Fibrinogen-like 1 | Structural protein |
Y00264 | 2.6 | 0.7 | 6427 | 2729 | Amyloid beta (A4) precursor protein | Signal transduction |
U40846 | 2.5 | 0.7 | 620 | 275 | Alpha-N-acetylglucosaminidase | Metabolism |
M31013 | 2.5 | 1.2 | 2418 | 814 | Myosin, heavy polypeptide 9, non-muscle | Structural protein |
D50683 | 2.5 | 0.5 | 1169 | 402 | TGF-betaIIR alpha | Signal transduction |
Z84483 | 2.5 | 1.1 | 1184 | 380 | DNA sequence from PAC 46H23, BRCA2 gene region | Unknown |
U08989 | 2.5 | 1.1 | 1308 | 499 | Glutamate transporter | Transport |
M69181 | 2.5 | 0.6 | 447 | 77 | Myosin, Heavy Polypeptide 10, Non-Muscle | Structural protein |
U71601 | 2.4 | 1.1 | 924 | 205 | Zinc finger protein 47 | Unknown |
U88902 | 2.4 | 0.7 | 1626 | 864 | Integrase | Unknown |
D78367 | 2.4 | 0.6 | 1569 | 1083 | K12 keratin | Structural protein |
M83233 | 2.4 | 0.8 | 737 | 136 | Transcription factor 12 | Transcription factor |
X16663 | 2.4 | 0.4 | 1710 | 610 | Hematopoietic cell specific Lyn substrate 1 | Inflammatory response |
U46767 | 2.3 | 0.3 | 574 | 24 | Small inducible cytokine subfamily A (Cys-Cys) 13 | Inflammatory response |
U38904 | 2.3 | 0.5 | 1992 | 723 | Zinc finger protein 211 | Transcription factor |
M88162 | 2.3 | 0.7 | 4200 | 2220 | Lowe Oculocerebrorenal Syndrome Protein | Signal transduction |
X63575 | 2.3 | 0.4 | 1210 | 444 | ATPase, Ca++ transporting, plasma membrane 4 | Calucium metabolism |
X07438 | 2.3 | 0.3 | 911 | 286 | Retinol binding protein 1, cellular | Transport |
U62293 | 2.3 | 0.4 | 459 | 65 | LIM-kinase1 | Signal transduction |
K03430 | 2.2 | 0.7 | 2024 | 643 | Complement C1q B-chain | Unknown |
S59184 | 2.2 | 0.4 | 1061 | 364 | RYK receptor-like tyrosine kinase | Growth regulatory protein |
U09278 | 2.2 | 0.4 | 554 | 107 | Fibroblast activation protein | Growth regulatory protein |
U78556 | 2.2 | 0.6 | 1708 | 678 | Cisplatin resistance associated | Stress response |
M73720 | 2.2 | 0.9 | 1830 | 727 | Carboxypeptidase A3 (mast cell) | Protein metabolism |
Z79581 | 2.2 | 0.5 | 730 | 186 | LAZ3/BCL6 | Unknown |
X63717 | 2.2 | 0.4 | 988 | 242 | Fas antigen | Cell apoptosis protein |
Y10207 | 2.2 | 0.5 | 2822 | 249 | CD171 | Unknown |
X69910 | 2.2 | 0.4 | 893 | 457 | p63 | Structural protein |
Y00477 | 2.2 | 0.4 | 4388 | 2157 | Elastase 2 | Inflammatory response |
D50310 | 2.1 | 0.4 | 21543 | 9621 | Cyclin I | Growth regulatory protein |
S67334 | 2.1 | 0.9 | 683 | 176 | Phosphatidylinositol 3-Kinase P110, Beta Isoform | Signal transduction |
U12767 | 2.1 | 0.4 | 721 | 260 | Nuclear receptor 4A3 | Signal transduction |
J05243 | 2.1 | 0.4 | 2261 | 1057 | Spectrin, alpha, non-erythrocytic 1 | Structural protein |
M10277 | 2.1 | 0.2 | 47225 | 20451 | Actin, beta | Structural protein |
X51757 | 2.1 | 0.4 | 380 | 0 | Heat shock 70kD protein 6 | Stress response |
X02419 | 2.1 | 0.3 | 1132 | 546 | Plasminogen activator, urokinase | Metabolism |
D79990 | 2.1 | 0.4 | 275 | 8 | Ras association (RalGDS/AF-6) domain family 2 | Unknown |
U33317 | 2.1 | 0.3 | 526 | 0 | Defensin, alpha 6 | Stress response |
M34715 | 2.1 | 0.2 | 665 | 131 | Pregnancy specific beta-1-glycoprotein | Unknown |
X54870 | 2.1 | 0.4 | 2122 | 1109 | Killer cell lectin-like receptor subfamily C, member 4 | Inflammatory response |
J02763 | 2.1 | 0.3 | 16297 | 8750 | Calcyclin | Growth regulatory protein |
X04325 | 2.1 | 0.3 | 1693 | 945 | Gap junction protein, beta 1, 32kD | Cell adhesion protein |
U59863 | 2.0 | 0.4 | 813 | 275 | TRAF-interacting protein I-TRAF | Stress response |
U60269 | 2.0 | 0.5 | 1299 | 709 | Endogenous retrovirus HERV-K(HML6) proviral clone HML6.17 | Virus |
M94856 | 2.0 | 0.6 | 2494 | 1331 | Fatty acid binding protein 5 | Metabolism |
X81198 | 2.0 | 0.4 | 2001 | 1121 | Archain 1 | Transport |
U07158 | 2.0 | 0.4 | 2055 | 1222 | syntaxin 4A | Transport |
M28713 | 2.0 | 0.4 | 6263 | 3341 | NADH-cytochrome B5 reductase | Energy metabolism |
D14664 | 2.0 | 0.2 | 239 | 0 | KIAA0022 | Unknown |
D63481 | 2.0 | 0.3 | 5978 | 2876 | KIAA0147 | Unknown |
*The fold change represents the average of nine pairwise comparisons between the three CR and control monkeys. The SE was calculated for the nine pairwise comparisons by dividing the standard deviation by the square root of 3. The values presented for Signal Intensity (SI) are the averages of three rhesus monkeys per diet group. The method by which SI is used to estimate fold changes is described in Methods in the printed paper.