Supplementary material for Kayo et al. (April 17, 2001) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.081061898

Table 8.

Caloric restriction-related increases in gene expression in vastus lateralis of rhesus monkeys*

ORF

Fold Change

With CR

SE

SI

CR

SI Control

Gene

Class

X64559

10.3

3.4

4153

70

Tetranectin

Unknown

S53175

9.0

1.2

2707

0

NADH-Ubiquinone Oxidoreductase, 51 Kda Subunit

Energy metabolism

X73039

8.5

3.9

4426

723

Sox 12

Growth regulatory protein

Z74616

8.2

2.8

4942

591

Collagen I, alpha 2

Structural protein

S81737

7.0

2.0

3309

923

Syntrophin, alpha 1

Structural protein

M60832

5.8

0.9

1086

0

Collagen VIII, alpha 2

Structural protein

M19878

5.4

1.8

3908

979

Calbindin 1

Energy metabolism

U54617

5.3

3.0

2321

260

Pyruvate dehydrogenase kinase isoform 4

Energy metabolism

X06700

5.1

1.7

6116

1121

Collagen III, alpha 1

Structural protein

M63391

5.1

1.8

57549

14742

Desmin

Structural protein

U52101

4.5

1.1

1804

350

Epithelial membrane protein 3

Growth regulatory protein

M55998

4.3

1.2

48707

12855

Collagen I, alpha 1

Structural protein

X90858

4.1

1.9

3310

585

Uridine phosphorylase

DNA metabolism

D63391

4.0

1.3

2408

205

Platelet activating factor acetylhydrolase IB, gamma

Growth regulatory protein

X13916

4.0

0.9

1286

268

LDL receptor related protein 1

Energy metabolism

U53874

3.9

0.8

1304

167

Blue Cone Photoreceptor Pigment

Structural protein

X53416

3.8

2.2

992

74

Filamin A, alpha

Structural protein

X01703

3.8

0.7

4764

1848

Tubulin, alpha, brain-specific

Structural protein

X62515

3.7

1.1

1046

109

Heparan sulfate proteoglycan 2

Structural protein

X02761

3.7

1.1

11557

3492

Fibronectin 1

Structural protein

M62831

3.6

1.0

1213

87

Transcription factor ETR101

Transcription factor

X99393

3.6

1.6

397

92

Chemokine (C-C motif) receptor 5

Inflammatory response

L40394

3.6

0.4

202

0

Regulator of G protein signalling 6

Signal transduction

D78156

3.5

1.7

3998

311

RAS p21 protein activator 2

Signal transduction

X82207

3.5

1.5

931

0

Centractin, beta

Structural protein

X80590

3.4

1.6

21221

11178

Phosphorylase kinase, gamma 1 (muscle)

Signal transduction

D38305

3.2

1.4

20202

8682

Transducer of ERBB2, 1

Growth regulatory protein

X56667

3.1

0.8

908

71

Calbindin 2

Calucium metabolism

X98248

3.1

0.6

4125

1421

Sortilin 1

Transport

X52022

3.1

0.8

4173

1789

Collagen VI, alpha 3

Structural protein

X05855

3.1

1.2

5789

2368

H3 histone 3A

Structural protein

X72012

3.0

0.7

2892

970

Endoglin

Structural protein

M73780

3.0

0.4

518

7

Integrin, beta 8

Cell adhesion protein

X79353

2.9

1.6

4413

1300

GDP dissociation inhibitor 1

Signal transduction

M18078

2.9

1.2

1101

67

Statherin

Metabolism

A15293

2.8

0.5

1682

529

Albumin

Serum protein

X51362

2.8

1.4

2533

711

Dopamine receptor D2

Neurotransmission

Z26653

2.8

0.6

1958

716

Laminin, alpha 2

Structural protein

U21128

2.8

0.6

2952

1038

Lumican

Structural protein

L13698

2.8

0.7

1543

469

Growth arrest-specific 1

Growth regulatory protein

M20747

2.8

0.8

5498

2656

GLUT4

Transport

D38583

2.8

0.4

1711

642

Calgizzarin

Structural protein

M80563

2.8

0.5

12621

4173

CAPL

Growth regulatory protein

X97074

2.7

1.1

2239

911

Clathrin-associated/assembly/adaptor protein, small 2 (17kD)

Transport

X14474

2.7

0.8

4789

2123

Microtubule-associated tau protein

Structural protein

X98253

2.7

0.6

4126

1675

Zinc finger protein 183

Unknown

M74099

2.7

0.7

3151

1195

Cut (Drosophila)-like 1

Transcription factor

Z48512

2.7

1.1

2480

440

Sex-determining region Y (SRY)

Transcription factor

U62317

2.7

0.7

964

293

Hypothetical protein 384D8_2 gene

Unknown

M62403

2.7

1.4

3154

1109

Insulin-like growth factor binding protein 4

Growth regulatory protein

M19720

2.7

0.6

1373

185

L-myc

Growth regulatory protein

U18009

2.6

0.7

674

1

Clone LF113

Unknown

L43631

2.6

0.8

2192

972

Scaffold attachment factor B

Structural protein

S80562

2.6

0.5

917

190

Calponin 3, acidic

Structural protein

X66436

2.6

0.6

4649

2881

Guanine nucleotide binding protein-like 1

Signal transduction

D86977

2.6

0.6

1507

361

KIAA0224

Unknown

D14446

2.6

0.6

900

252

Fibrinogen-like 1

Structural protein

Y00264

2.6

0.7

6427

2729

Amyloid beta (A4) precursor protein

Signal transduction

U40846

2.5

0.7

620

275

Alpha-N-acetylglucosaminidase

Metabolism

M31013

2.5

1.2

2418

814

Myosin, heavy polypeptide 9, non-muscle

Structural protein

D50683

2.5

0.5

1169

402

TGF-betaIIR alpha

Signal transduction

Z84483

2.5

1.1

1184

380

DNA sequence from PAC 46H23, BRCA2 gene region

Unknown

U08989

2.5

1.1

1308

499

Glutamate transporter

Transport

M69181

2.5

0.6

447

77

Myosin, Heavy Polypeptide 10, Non-Muscle

Structural protein

U71601

2.4

1.1

924

205

Zinc finger protein 47

Unknown

U88902

2.4

0.7

1626

864

Integrase

Unknown

D78367

2.4

0.6

1569

1083

K12 keratin

Structural protein

M83233

2.4

0.8

737

136

Transcription factor 12

Transcription factor

X16663

2.4

0.4

1710

610

Hematopoietic cell specific Lyn substrate 1

Inflammatory response

U46767

2.3

0.3

574

24

Small inducible cytokine subfamily A (Cys-Cys) 13

Inflammatory response

U38904

2.3

0.5

1992

723

Zinc finger protein 211

Transcription factor

M88162

2.3

0.7

4200

2220

Lowe Oculocerebrorenal Syndrome Protein

Signal transduction

X63575

2.3

0.4

1210

444

ATPase, Ca++ transporting, plasma membrane 4

Calucium metabolism

X07438

2.3

0.3

911

286

Retinol binding protein 1, cellular

Transport

U62293

2.3

0.4

459

65

LIM-kinase1

Signal transduction

K03430

2.2

0.7

2024

643

Complement C1q B-chain

Unknown

S59184

2.2

0.4

1061

364

RYK receptor-like tyrosine kinase

Growth regulatory protein

U09278

2.2

0.4

554

107

Fibroblast activation protein

Growth regulatory protein

U78556

2.2

0.6

1708

678

Cisplatin resistance associated

Stress response

M73720

2.2

0.9

1830

727

Carboxypeptidase A3 (mast cell)

Protein metabolism

Z79581

2.2

0.5

730

186

LAZ3/BCL6

Unknown

X63717

2.2

0.4

988

242

Fas antigen

Cell apoptosis protein

Y10207

2.2

0.5

2822

249

CD171

Unknown

X69910

2.2

0.4

893

457

p63

Structural protein

Y00477

2.2

0.4

4388

2157

Elastase 2

Inflammatory response

D50310

2.1

0.4

21543

9621

Cyclin I

Growth regulatory protein

S67334

2.1

0.9

683

176

Phosphatidylinositol 3-Kinase P110, Beta Isoform

Signal transduction

U12767

2.1

0.4

721

260

Nuclear receptor 4A3

Signal transduction

J05243

2.1

0.4

2261

1057

Spectrin, alpha, non-erythrocytic 1

Structural protein

M10277

2.1

0.2

47225

20451

Actin, beta

Structural protein

X51757

2.1

0.4

380

0

Heat shock 70kD protein 6

Stress response

X02419

2.1

0.3

1132

546

Plasminogen activator, urokinase

Metabolism

D79990

2.1

0.4

275

8

Ras association (RalGDS/AF-6) domain family 2

Unknown

U33317

2.1

0.3

526

0

Defensin, alpha 6

Stress response

M34715

2.1

0.2

665

131

Pregnancy specific beta-1-glycoprotein

Unknown

X54870

2.1

0.4

2122

1109

Killer cell lectin-like receptor subfamily C, member 4

Inflammatory response

J02763

2.1

0.3

16297

8750

Calcyclin

Growth regulatory protein

X04325

2.1

0.3

1693

945

Gap junction protein, beta 1, 32kD

Cell adhesion protein

U59863

2.0

0.4

813

275

TRAF-interacting protein I-TRAF

Stress response

U60269

2.0

0.5

1299

709

Endogenous retrovirus HERV-K(HML6) proviral clone HML6.17

Virus

M94856

2.0

0.6

2494

1331

Fatty acid binding protein 5

Metabolism

X81198

2.0

0.4

2001

1121

Archain 1

Transport

U07158

2.0

0.4

2055

1222

syntaxin 4A

Transport

M28713

2.0

0.4

6263

3341

NADH-cytochrome B5 reductase

Energy metabolism

D14664

2.0

0.2

239

0

KIAA0022

Unknown

D63481

2.0

0.3

5978

2876

KIAA0147

Unknown

*The fold change represents the average of nine pairwise comparisons between the three CR and control monkeys. The SE was calculated for the nine pairwise comparisons by dividing the standard deviation by the square root of 3. The values presented for Signal Intensity (SI) are the averages of three rhesus monkeys per diet group. The method by which SI is used to estimate fold changes is described in Methods in the printed paper.