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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Neurochem Int. 2012 Jan 17;61(4):581–592. doi: 10.1016/j.neuint.2012.01.004

Figure 2.

Figure 2

Drug binding sites on the NMDA receptor complex. A. Ribbon representation of a GluN2A subunit showing the domain structure and the NTD cleft where Zn++ is thought to bind (green arrow) and the LBD cleft (black arrows). B. Crystal structure (3QEL, Karakas et al., 2011) of the GluN1/GluN2B NTD dimer with ifenprodil (orange) bound to the dimer interface. C. and D. GluN1/GluN2A LBD dimer - 2A5T, (Furukawa et al., 2005) with glutamate (green) and glycine (yellow) bound in the LBD clefts (black arrows). Purple ovals represent one of multiple potential sites for NAM/PAM binding based upon homology to cyclothiazide and CX614 binding to AMPA receptors. View of LBD dimer is parallel to membrane (C) or perpendicular to the membrane from above (D). Figures were generated using MolegroMolecular Viewer (Aarhus, Denmark) and the Protein Data Bank (PDB) files 3QEL and 2A5T.