Molecular Recognition of Candida albicans (1→2)-β-Mannan Oligosaccharides by a Protective Monoclonal Antibody Reveals the Immunodominance of Internal Saccharide Residues

Supplemental Data

Files in this Data Supplement:

• Supplemental Figure 1 (.pdf, 1.3 MB) - Scatter plots of phi vs. psi of 2 from molecular dynamics simulations.
• Supplemental Figure 2 (.pdf, 240 KB) - Relaxed potential energy contour plot for the Man(β1-2)Man(βOMe) disaccharide.
• Supplemental Figure 3 (.pdf, 115 KB) - Surface plasmon resonance of C3.1 scFv binding to oligosaccharides at equilibrium.
• Supplemental Table 1 (.pdf, 47 KB) - Saturation transfer double difference enhancements for compounds 1-3 binding to antibody C3.1.
• Supplemental Experimental Procedures (.pdf, 98 KB) - Supplementary Experimental Procedures