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. 2010 Oct 21;2(2):82–89. doi: 10.1021/cn100078a

Figure 2.

Figure 2

The ability of tariquidar to inhibit the function of three ABC transporters (P-gp, BCRP, and MRP1) as measured by the uptake of the fluorescent substrates calcein-AM and mitoxantrone in three pairs of human cell lines. At ≥100 nM, tariquidar inhibits both (A) P-gp and (B) BCRP function, but not (C) MRP1 function. Mean fluorescence intensity ± SD from three observations, reported as accumulation of fluorescent substrate, is normalized to accumulation in untreated parental cells. Abbreviations: calcein-AM (Ca-AM), mitoxantrone (MTX), fumitremorgin C (FTC, BCRP inhibitor; 5 μM), cyclosporin A (CsA, P-gp inhibitor; 10 μM), tariquidar (TQR), MK-571 (MRP1 inhibitor).