Mycobacterium tuberculosis Lacking All Mycolic Acid Cyclopropanation Is Viable but Highly Attenuated and Hyperinflammatory in Mice

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 - Table S1. Primers used for RT-PCR analysis.
  Table S2. Pulmonary IFN-γ response of C57BL/6 mice infected intratracheally with M. tuberculosis WT, MGM1990, or MGM1991.
  Table S3. Spleen cell cytokine responses of C57BL/6 mice infected intratracheally with 10⁴ CFU of M. tuberculosis WT, MGM1990, or MGM1991.
  Table S4. Spleen cell cytokine responses of C57BL/6 mice infected intratracheally with 10⁴ CFU of M. tuberculosis WT, MGM1990, or MGM1991.
  Fig. S1. Confirmation of PDIM biosynthesis in mycolic acid methyltransferases knockouts.
  Fig. S2. Mycolic acid analysis of in vivo revertants of MGM1990.
  PDF file, 1.3 MB.