A Potent Plant-Derived Antifungal Acetylenic Acid Mediates Its Activity by Interfering with Fatty Acid Homeostasis

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 - Gene expression responses to 6NDA in S. cerevisiae.
  PDF file, 276K.
• Supplemental file 2 - List of 166 transcription factors deleted in mutants assayed in this study.
  PDF file, 61K.
• Supplemental file 3 - Gene expression responses to 6NDA in S. cerevisiae strain BY4742.
  PDF file, 187K.
• Supplemental file 4 - Gene expression responses to 6NDA in C. albicans.
  PDF file, 151K.
• Supplemental file 5 - Primers for real-time RT-PCR assays on C. albicans genes.
  PDF file, 15K.
• Supplemental file 6 - Fig. S1, comparison of gene expression responses to 6-NDA between S. cerevisiae BY4742 and S288C strains. Fig. S2, PCR confirmation of 14 transcription factor mutant strains. Fig. S3, quantitative real-time RT-PCR analysis of fatty acid β-oxidation genes in 6-NDA-exposed C. albicans cells.
  PDF file, 378K.
• Supplemental file 7 - Supplemental methods for quantitative real-time RT-PCR analysis in C. albicans.
  PDF file, 21K.