Table 1. Effects of clioquinol and analogues on the viability of Raji cells.
Cells were treated with increasing concentrations of the compounds in the presence or absence of 50 μM ZnCl2 or 10 μM CuCl2. Cell viability was analyzed using the MTS assay and IC50 values were calculated (mean ± SEM, from three independent experiments).
| Compounds | Structure | Drug alone IC50, μM | +ZnCl2 IC50, μM | +CuCl2 IC50, μM |
|---|---|---|---|---|
| Clioquinol |
|
5.09±020 | 3.30±0.38 | 1.89±0.25 |
| 8-Hydroxy-5-nitroquinoline (NQ) |
|
0.438±0.20 | 0.855±0.18 | 0.0003±0.0 |
| 5,7-Diiodo-8-hydroxyquinoline (IIQ) |
|
5.54±0.26 | 4.52±0.22 | 2.09±0.20 |
| 5-Chloro-8-quinoline (CQ2) |
|
5.49±0.22 | 7.20±0.27 | 3.49±0.18 |
| 8-Hydroxyquinoline (8HQ) |
|
1.98±0.23 | 6.92±0.14 | 0.03±0.002 |
| 5,7-Dichloro-8-quinolinol (CCQ) |
|
1.44±0.15 | 1.40±0.2 | 0.133±0.03 |
| 5-Amino-8-quinolinol dihydrochloride (A8HQ) |
|
5.44±0.13 | 8.56±0.15 | 1.93±0.10 |