Cot Kinase Promotes Ca²⁺ Oscillation/Calcineurin-Independent Osteoclastogenesis by Stabilizing NFATc1 Protein

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 -

  Supplemental text

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• Supplemental file 2 -

  Fig. S1 (Number of nuclei in multinuclear osteoclasts overexpressing trCot)

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• Supplemental file 3 -

  Fig. S2 (Effect of FK506 on RANKL and OPG expression)

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• Supplemental file 4 -

  Fig. S3 (Amino acid alignment of N-terminal regions of NFATc forms)

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• Supplemental file 5 -

  Fig. S4 (NFATc1 localization in RANKL-treated or nontreated cells)

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• Supplemental file 6 -

  Fig. S5 (Bone histomorphometric parameters of osteoclastic bone resorption and bone volume in the tibia)

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• Supplemental file 7 -

  Fig. S6 (Osteoblastogenesis)

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