Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten -- Data Supplement - HTML Page - 08217Fig6Legend.htslp -- Proceedings of the National Academy of Sciences

Supporting Figure 6 Fig. 6.
Cellular atypia and focal invasion in Pten^loxP/loxP; MMTV-cre prostate tumors. Cellular atypia in Pten mutant prostate tumors includes prominent nucleoli, pleiomorphism, loss of polarity, and pale-staining cytoplasm (B). Normal cellular appearance is seen in control glands (A). Prostate neoplasms invading the muscular tissue of Pten mutant males (C, arrowhead, 9 wk). Comedocarcinoma is evident within center of prostate carcinoma in situ lesion from 9-wk Pten mutant male in D. (E) Basal and luminal cells of the Pten mutant prostate glands (black bars) were increased in number by 3.4- and 3.5-fold, respectively, compared with heterozygous controls (white bars) at 6 wk (n = 3 for each genotype, P < 0.004). (Scale bars: A and B, 10 m m; C and D, 50 m m.)