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Supplemental materials and methods. Fig. S1. ESI-MS the S. Typhimurium msbB mutant and its derivatives in the singly charged region. Fig. S2. Alteration in LPS profiles and its impact on growth. Fig. S3. LPS-induced cytokine production in cultured Mono Mac 6 (MM6). Table S1. Strains and plasmids used in this work. Table S2. Primers used in this work. Table S3. Peaks in Fig. 1 and Fig. S1 and their corresponding mass and lipid A structures. Table S4. In vitro phenotype determination of S. Typhimurium wild-type strain χ3761 and its mutant derivatives. Table S5. Cytokines and chemokines concentration in pooled sera obtained from mice 6 days after receiving S. Typhimurium mutants via oral route. Table S6. Protection efficacy of S. Typhimurium vaccine strains delivering PspA against challenge with virulent S. pneumoniae strain WU2 determined in BALB/c mice.
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