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Cell cytotoxicity of DFD-VI-15, BD-I-186, DFD-V-66, and DFD-V-49 against the human HepG2 cell line. Viability assays were used to determine the CC50 concentration with neutral red (upper) and MTT (lower) stains. Assays were performed at 24, 48, and 72 h. The CC50s for BD-I-186 and DFD-V-49 are 100 μg/ml, or about 50- to 60-fold higher than the MIC50, for each compound. For DFD-VI-15 and DFD-V-66, the CC50s were 10- to 20-fold and 30- to 50-fold greater, respectively.
