Table 3.
Maximum kill rates (KRmax) against C. albicans CAF2a
| Compound | KRmax (per h)b |
|---|---|
| DFD-VI-15 | 0.85 ± 0.05 |
| BD-I-186 | 0.75 ± 0.07 |
| DFD-V-66 | 0.80 ± 0.03 |
| DFD-V-49 | 0.67 ± 0.08 |
| Fluconazole | 0.25 ± 0.10 |
| Micafungin | 0.90 ± 0.04 |
| Amphotericin B | 0.80 ± 0.08 |
a
The maximum kill rates for DFD-VI-15, BD-I-186, DFD-V-66, DFD-V-49, fluconazole, micafungin, and amphotericin B against C. albicans CAF2 were compared. The BZT derivatives have comparable maximum kill rates to amphotericin B and micafungin but those rates are significantly higher than that to fluconazole. Greater kill rates are indicated by higher KRmax values.
b
KRmax (per h) data are averages of results from three experiments.