Table 5.
Activity (MIC50) of BZT compounds against micafungin- and amphotericin-resistant strains of C. albicans and C. glabrataa
| Strainb | Mechanism of resistancec | MIC50 of BZT compounds (μg/ml) | MIC50 of micafungin/ AmB (μg/ml) | Source or referenced |
|---|---|---|---|---|
| C. albicans | ||||
| ATCC 90028 | 1.6 | 0.016/0.25 | This paper | |
| DSP11 | AA (FKS1) S645F | 3.2 | 2 | 22, 46 |
| DSP12 | AA (FKS1) S645Y | 3.2 | 2 | 22, 46 |
| DSP14 | AA (FKS1) F641S | 3.2 | >2 | 22, 46 |
| DSP15 | AA (FKS1) S645P | 3.2 | 2 | 22, 46 |
| C. glabratae | ||||
| RC-201 | 0.8–3.2 | 0.016/0.25 | This paper | |
| DSP16 | AA (FKS2) S663P | 1.6–3.2 | 1 | 22, 46 |
| DSP17 | AA (FKS1) S645P | 1.6–3.2 | >2 | 22, 46 |
| DSP18 | AA (FKS1) F659V | 0.8–3.2 | >2 | 22, 46 |
| DSP19 | AA (FKS2) S663P | 1.6–3.2 | >2 | 22, 46 |
| DSP20 | AA (FKS1) D666E | 1.6–3.2 | 1 | 22, 46 |
a
Strain numbers, mechanisms of resistance, and MIC50 values are shown. The MIC50 values reflect the range of MIC50 values for all BZT compounds against all strains.
b
DSP 11–15, C. albicans strains. DSP 16–20 and strain 21230, C. glabrata strains.
c
AA, point mutants of FKS1 or FKS2.
d
References that describe the source and/or resistance mechanisms are included.
e
C. glabrata 21230 was also resistant to amphotericin B (56 and data not shown).