Table 6.
Results of checkerboard experimentsa
| Compound | Interaction type (FICI) |
||
|---|---|---|---|
| Fluconazole | Micafungin | Amphotericin B | |
| DFD-VI-15 | Additive (1.0) | Additive (0.5) | Additive (0.6) |
| BD-I-186 | Additive (1.5) | Synergy (0.3) | Additive (1.3) |
| DFD-V-66 | Additive (1.2) | Additive (0.8) | Additive (1.0) |
| DFD-V-49 | Additive (1.0) | Additive (1.0) | Synergy (0.25) |
a
Checkerboard experiments identify synergy. The in vitro interactions of the active compounds with fluconazole, micafungin, and amphotericin B were evaluated against those for C. albicans CAF2. The FICI (fractional inhibitory concentration) values are calculated, and the interactions are grouped. BD-I-186 has a synergistic interaction with micafungin, and DFD-V-49 has a synergistic interaction with amphotericin B. All other interactions were additive. No antagonistic interactions were observed. See text for definitions.