Table 7.
Functions of selected genes deleted in the S. cerevisae BY4743 DFD-VI-15 hypersensitive mutantsa
| Biological process | Gene(s) |
|---|---|
| Mitochondrial morphology | ERG6, ERG4, ERG24, ERG3, SAC1 |
| Mitochondrial DNA replication | ABF2 |
| Mitochondrial ribosomal protein | PET123, MRP51 |
| Mitochondrial inner membrane | YME1 |
| Mitochondrial protein maturation | ISA2 |
| Mitochondrial glutathione reductase | GLR1 |
| Amino acid biosynthesis | TRP1, ARO2, ILV1, TRP5, THR1 |
| Transcription factor, iron utilization | AFT1 |
| Transcription factor, stress response | RPN4 |
| Nitrogen catabolite repression | URE2 |
| Zinc-regulated transcription factor | ZAP1 |
| Meiotic gene regulation | UME6 |
| Mitotic cell cycle spindle orientation | LTE1 |
| Protein sorting, ribosome stalk | VPS34, RPP1A, SEC66 |
| Chromatin remodeling | SNF2 |
| tRNA synthesis | ELP6 |
a
Functional annotation of C. albicans CAF2 orthologs. For C. albicans, ZAP1, UME6, and VPS34 are required for hyphal development; ZAP1 is also a regulator of biofilm formation.