Intravenous Ferumoxytol Allows Noninvasive MR Imaging Monitoring of Macrophage Migration into Stem Cell Transplants

© RSNA, 2012




Supplemental Figures

 

Fig E1

Figure E1: Prussian blue staining of liver, spleen, and bone marrow (BM) in a representative rat at week 0 and at week 4 after intravenous administration of ferumoxytol shows positive staining (blue), which suggests the presence of iron (ferumoxytol) in these RES organs. Corresponding organs in a control animal that was not injected with ferumoxytol show minimal Prussian blue staining in liver and bone marrow, as well as positive staining in the spleen (representing endogenous iron).

 

Fig E2

Figure E2: Representative blood smear obtained in a study rat 48 hours after intravenous ferumoxytol injection shows negative Prussian blue staining of a circulating monocyte.