© RSNA, 2012
Figure E1: Prussian blue staining of liver, spleen, and bone marrow (BM) in a representative rat at week 0 and at week 4 after intravenous administration of ferumoxytol shows positive staining (blue), which suggests the presence of iron (ferumoxytol) in these RES organs. Corresponding organs in a control animal that was not injected with ferumoxytol show minimal Prussian blue staining in liver and bone marrow, as well as positive staining in the spleen (representing endogenous iron).