Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity

DEV081513 Supplementary Material

Files in this Data Supplement:

  • Movie 1 -

    Movie 1. The centrosome localizes near the PAS during peripheral axon initiation. Movie of neuron shown in Fig. 3C labeled with TagRFP-CAAX in a GFP-Xcentrin mRNA-expressing embryo. Images were captured every minute. Yellow arrowhead indicates centrosome.

  • Movie 2 -

    Movie 2. The centrosome moves to the PAS as the successful axon begins extension. Movie of neuron shown in Fig. 3E labeled with GFP-Zcentrin only. A neurite initiates and retracts on the left. The successful axon forms from the cell body and the centrosome moves to its PAS as it begins extension.

  • Movie 3 -

    Movie 3. DN-CLIM causes centrosome mispositioning and aberrant axons. Movie of neuron shown in Fig. 5A labeled with TagRFP-CAAX in a GFP-Xcentrin mRNA- and DN-CLIM-expressing embryo. The centrosome (yellow arrowhead) is positioned more apically during ectopic apical neurite formation.