Gene ontology analysis of Malawi HKA high outliers GO_category_number number_significant_genes number_total_genes_analyzed P_value classification GO_category_description GO:0016459 8 17 0.0001 cellular myosin complex GO:0043138 3 6 0.00074 molecular 3'-5' DNA helicase activity GO:0046872 8 35 0.00097 molecular metal ion binding GO:0006901 3 6 0.00176 biological vesicle coating GO:0005777 5 17 0.00195 cellular peroxisome GO:0016183 3 7 0.00218 biological synaptic vesicle coating GO:0030135 3 8 0.00313 cellular coated vesicle GO:0004510 2 2 0.00398 molecular tryptophan 5-monooxygenase activity GO:0004505 3 3 0.00398 molecular phenylalanine 4-monooxygenase activity GO:0005656 2 3 0.00505 cellular pre-replicative complex GO:0006267 2 3 0.00505 biological pre-replicative complex assembly GO:0006727 3 6 0.00572 biological ommochrome biosynthetic process GO:0030175 2 2 0.0063 cellular filopodium (leading edge of motile cell) GO:0055037 2 3 0.00667 cellular recycling endosome GO:0050660 8 38 0.00824 molecular FAD binding GO:0015280 2 2 0.00841 molecular epithelial sodium channel GO:0006359 2 4 0.00863 biological regulation of transcription from RNA polymerase III promoter GO:0007031 3 9 0.00882 biological peroxisome organization GO:0006270 2 5 0.00945 biological DNA-dependent DNA replication initiation GO:0005053 2 2 0.00989 molecular peroxisome matrix targeting signal-2 binding GO:0016327 5 9 0.01304 cellular apicolateral plasma membrane (epithelial cells) GO:0050839 6 11 0.01361 molecular cell adhesion molecule binding GO:0005912 7 16 0.01627 cellular adherens junction GO:0005085 10 25 0.01709 molecular guanyl-nucleotide exchange factor activity GO:0016461 3 6 0.01725 cellular unconventional myosin complex GO:0005506 6 33 0.01744 molecular iron ion binding GO:0048790 2 4 0.01795 biological maintenance of presynaptic active zone structure GO:0035091 4 17 0.01874 molecular phosphoinositide binding GO:0003997 2 4 0.01955 molecular acyl-CoA oxidase activity GO:0005319 2 2 0.01996 molecular lipid transporter activity GO:0017112 2 2 0.02029 molecular Rab guanyl-nucleotide exchange factor activity GO:0005666 2 7 0.02118 cellular DNA-directed RNA polymerase III complex GO:0005914 2 2 0.02222 cellular spot adherens junction GO:0043296 2 2 0.02222 cellular apical junction complex GO:0003746 3 15 0.0235 molecular translation elongation factor activity GO:0015277 3 8 0.02415 molecular kainate selective glutamate receptor activity GO:0003774 10 39 0.02475 molecular motor activity GO:0045571 2 2 0.02539 biological negative regulation of imaginal disc growth GO:0042623 10 50 0.02555 molecular "ATPase activity, coupled" GO:0006414 2 10 0.02576 biological translational elongation GO:0042045 2 3 0.02617 biological epithelial fluid transport GO:0016328 3 5 0.02755 cellular lateral plasma membrane (epithelial cells) GO:0030708 3 5 0.02775 biological germarium-derived female germ-line cyst encapsulation GO:0055114 25 235 0.02815 biological oxidation reduction GO:0008021 7 29 0.02856 cellular synaptic vesicle GO:0016203 8 18 0.03221 biological muscle attachment GO:0018108 2 2 0.03236 biological peptidyl-tyrosine phosphorylation GO:0000212 3 7 0.03239 biological meiotic spindle organization GO:0006886 6 41 0.03303 biological intracellular protein transport GO:0006726 2 5 0.03414 biological eye pigment biosynthetic process GO:0006090 2 7 0.03433 biological pyruvate metabolic process GO:0005200 8 30 0.03471 molecular structural constituent of cytoskeleton GO:0015381 2 5 0.03564 molecular high affinity sulfate transmembrane transporter activity GO:0004091 5 19 0.03643 molecular carboxylesterase activity GO:0004760 2 2 0.03713 molecular serine-pyruvate transaminase activity GO:0042070 2 2 0.03792 biological maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification GO:0007586 2 6 0.03937 biological digestion GO:0030131 2 5 0.04048 cellular clathrin adaptor complex GO:0007166 7 22 0.04185 biological cell surface receptor linked signaling pathway GO:0008091 2 3 0.04216 cellular spectrin GO:0016055 9 30 0.04263 biological Wnt receptor signaling pathway GO:0045182 2 3 0.04426 molecular translation regulator activity GO:0046907 2 5 0.04429 biological intracellular transport GO:0042067 7 18 0.04435 biological establishment of ommatidial planar polarity GO:0003779 24 97 0.04478 molecular actin binding GO:0005739 12 117 0.04495 cellular mitochondrion GO:0043025 4 13 0.04526 cellular neuronal cell body GO:0051168 2 5 0.0453 biological nuclear export GO:0007164 4 7 0.04565 biological establishment of tissue polarity GO:0007280 6 14 0.04566 biological pole cell migration GO:0042742 3 14 0.04794 biological defense response to bacterium GO:0008057 3 6 0.04822 biological eye pigment granule organization GO:0008302 3 4 0.04902 biological "female germline ring canal formation, actin assembly" GO:0046578 2 3 0.04914 biological regulation of Ras protein signal transduction