HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 -

  Fig. S1 (Binding specificities of other CoRbs mAbs to gp120.)

  Fig. S2 (Binding specificities of other CoRbs mAbs to gp120 defined by competition ELISA.)

  Fig. S3 (Heavy chain and kappa chain amino acid sequence alignment of VRC06 and VRC06b with genetically related mAbs VRC03 and VRC01 based on the Kabat numbering system.)

  Table S1 (Antibody neutralization against 27 HIV-1 clade A Env pseudoviruses.)

  Table S2 (Antibody neutralization against 38 HIV-1 clade B Env pseudoviruses.)

  Table S3 (Antibody neutralization against 54 HIV-1 clade C Env pseudoviruses.)

  Table S4 (Antibody neutralization against nine HIV-1 clade D Env pseudoviruses.)

  Table S5 (Antibody neutralization against 16 HIV-1 CRF01_AE Env pseudoviruses.)

  Table S6 (Antibody neutralization against 16 CRF02_AG Env pseudoviruses.)

  Table S7 (Antibody neutralization against 17 HIV-1 recombinant and 1 clade G Env pseudovirus.)

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