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Fig. S1. NHE3 and ENaC in kidneys from WNK3 knockout mice. (A) Representative immunoblots of NHE3 and ENaC γ subunit in kidneys from wild-type and WNK3 knockout mice. The arrow in the ENaC γ subunit panel indicates a 70-kDa fragment of proteolytic cleavage. (B) Densitometry analyses of NHE3 and cleaved ENaC γ subunit in kidneys from wild-type and WNK3 knockout mice. For densitometry analysis, values (n = 15) are expressed as ratios against the average of signals in the wild-type group. There were no significant decreases in NHE3 and cleaved ENaC γ subunit in kidneys from WNK3 knockout mice, as compared to wild-type littermates. n.s. not significant.
