A Mammalian-Like DNA Damage Response of Fission Yeast to Nucleoside Analogs

Files in this data supplement:

  • Supporting Information: Figures S1-S4 and Files S1-S4 (PDF, 14.9 MB)
  • Figure S1: BrdU and EdU dose affects cell viability (refer to Figures 1 and 2) (PDF, 2.3 MB)
  • Figure S2: BrdU and EdU cause prolonged DNA synthesis, cell cycle slowing and DNA damage (related to Figure 3) (PDF, 3 MB)
  • Figure S3: BrdU pre-treatment changes sensitivity to mutagens (refer to Figure 6 (PDF, 3.1 MB)
  • Figure S4: Spd1 protects cells from division and mutation during dNTP imbalance (refer to Figure 7) (PDF, 6.7 MB)
  • File S1: Movie 1 (.mov, 2.4 MB)
  • File S2: Movie 2 (.mov, 2.6 MB)
  • File S3: Movie 3 (.mov, 2.4 MB)
  • File S4: Movie 4 (.mov, 1.9 MB)