A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion

Supplemental Data

Files in this Data Supplement:

• Supplemental Figures -

  Supplemental Figure 1 - Changes in 8-NBD-cAMP fluorescence as a function of EPAC2 and cyclic nucleotide concentrations

  Supplemental Figure 2 - Effects of ESI-09 on type I and II PKA activities

  Supplemental Figure 3 - ESI-09 inhibits EPAC-mediated Akt phosphorylation in INS-1 cells

  Supplemental Figure 4 - Effects of ESI-09 treatment on pancreatic cancer cell viability

  Supplemental Figure 5 - Expression levels of EPAC1 and EPAC2 in the PDA cell lines PANC-1 and AsPC-1