Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP

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  Fig. S1. Processing of pro-IL-1β in response to ATP depletion is dependent on Nlrp1b. Fig. S2. Nlrp1b allele 3 D927V does not support pro-IL-1β processing in response to ATP depletion. Fig. S3. Hypoxia increases pro-IL-1β processing in minimal medium. Fig. S4. AMPK facilitates Nlrp1b activity. Fig. S5. Effects of N-acetylcysteine and MG-132 on inflammasome activity. Fig. S6. Nlrp1b cleavage is not detected in response to ATP depletion. Fig. S7. LeTx and 2DG activate the Nlrp1b inflammasome in J774A cells.

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