Fig. 7.
Amino acid sequence (GenBank accession no. AY438374) comparisons between PKHD1 in humans and mice. The dashed box at the beginning indicates the signal sequence. Arrows in bold-type underlines indicate the predicted IPT/TIG domains. Dotted underlines mark the region used for producing antibodies. The dashed arrow indicates the predicted EF-hand motif. The solid-line box near the end of the sequence represents the predicted transmembrane domain. Several predicted phosphorylation sites in the cytoplasmic portion of fibrocystin/polyductin, which are conserved in both humans and mice, are indicated by plus signs for PKC phosphorylation and small open squares for casein kinase (Ck) 2 phosphorylation sites.