Fig. 6.
Enlarged chromosome 12 is not the result of telomeric fusion. The enlarged chromosome 12 (yellow arrow) in metaphase spreads from AP270 and contains no internal telomeric signal when assayed with a Cy3-conjugated peptide nucleic acid probe, which hybridizes to telomeric repeats (CCCTAA)3 as described (1).1. Rooney, S., Alt, F. W., Lombard, D., Whitlow, S., Eckersdorff, M., Fleming, J., Fugmann, S., Ferguson, D. O., Schatz, D. G. & Sekiguchi, J. (2003) J. Exp. Med. 197, 553-565.