Fig. 9.
Effects of AG1024 and ICI on the growth of MCF-7 cells. MCF-7 cells were pretreated with 1 mM AG1024 or 1 nM fulvestrant for 30 min and then were challenged with vehicle (open bar) or E2 at 0.1 nM (filled bar) for 3 days. Cell numbers were counted by using the Coulter counter method. *, P < 0.001 compared the combination of inhibitors plus E2 with E2 treated alone.