Supplementary FigureS3.Population PK studies of simvastatin.Simulation results of 1000 virtual patients are shown within a 98% prediction interval (grey shaded area). Clinical data for simvastatin lactone (upper panel) and simvastatin acid (lower panel)1are indicated for all three genotypes (a,b,c: simvastatin lactone; a: TT, black triangle (up); b: TC, dark grey diamonds; c: CC, light grey triangle (down); d,e,f: simvastatin acid; d: TT, black triangle (up); e: TC, dark grey diamonds; f: CC, light grey triangle (down)1.