Published April 8, 2013 // JEM vol. 210 no. 4 757-774
The Rockefeller University Press, doi: 10.1084/jem.20121416

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

Video 3.
Splenic antiviral T cell dynamics during acute versus persistent viral infection. (Part 1) Two representative time lapses of 3D reconstructions show CD8+ P14 cells (red), CD4+ SMARTA cells (green), and collagen (cyan) in the spleen 7 d after infection with Arm or CL13. The dotted lines demarcate the border between the splenic white and red pulp. White boxes denote areas of higher magnification shown in part 2. (Part 2) Time lapses showing higher magnifications of the areas denoted in part 1.