>AAD11514.1 ------------------------------------------------------------ --KVNKGFKF----RLYPTK-------EQQDK---------------------------- ------LQ---------------------------------------------------- --------------------------------------------------RCFFVYNQ-- ------------------------------------------------------------ -----------------------------AYN---------------------------- ------------------------------------------------IGLNLLQ----- -------------------------------------EQYETNKDSPPKERKWKKSSELD KAIKH----------------------HLNARGL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SFSSVIAQQ-------------- SRMNVER--------------ALKDAFKVKDR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GFPKFKN--------SKSAKQSFS WN---------------------------------------------------------- -------------------------------------------NQGFSIKDS--DEERFK IFTLMKMPL-------MMRMHRDFPPHSKV------------------------------ ------------------------------------KQIVISW----------------- -----------------------SHRKYFVSFCV-------------------------- ------------------------------------------------------------ ---EYEQDITPIKNPKNGVGLDL-NILD-IACSCG------------------------- ------------------------------------------------------------ ----VNNHKKLTDFKQYPTDMKELLGIEIDEELDTKRLIPTYSK-------LYSLKK--- ----------YSKKFKRLQRKQSRRVLKSKQNKTKL------------------------ -----------------------------------------------------------G GNFYKTQKK---------------------LNQ---AF-DKSSHQKTDRYHK-IT---SE LS-----------------------KQF--------E--LVVVEDLQ-VKNMTKRAK--- ----------------------LKNVKQKSGLNQ-SILNTSFYQIISFLDYKQQHN--GK -LLVKVPPQY-T--SKT--CH-CCG--NI---NHKLK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LNHR-Q--------------Y--WCLE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-REHRDINAANNIISKG--- -------------LSLFGVGN-------------------IHADFKEQSLSC-------- ---------- >ISCco1 ------------------------------------------------------------ --QITKGFKY----RLYPNK-------EQSLK---------------------------- ------LS---------------------------------------------------- --------------------------------------------------HQCFIYNQ-- ------------------------------------------------------------ -----------------------------AYN---------------------------- ------------------------------------------------ICLNLQQ----- -------------------------------------EQWLKNKELDKKERTYLSATQID NQVKL----------------------ALKARNL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EFKSVVAQQ-------------- ARINANR--------------ALEQAIKDKNK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GFPKFKN--------SKLAKQSFN WN---------------------------------------------------------- -------------------------------------------NQGYQIL-E--FNDKFK IFRLMSMPI-------KMRYHRALPNNYKL------------------------------ ------------------------------------NQITISK----------------- -----------------------THNKYFVSFSI-------------------------- ----------------------------------------------------------TY DEPSVVLMSSNKIDINRAVGIDM-NINE-IALSNG------------------------- ------------------------------------------------------------ ------------------------------------ALLLTCSK-------SINKAK--- ----------YSTTFKRLMRKQSKRVLKAKKDKIKL------------------------ -----------------------------------------------------------G SNFRKTQIR---------------------LNK---IY-ERASNIKKDLAHK-IS---NQ IV-----------------------KNF--------D--LIVVENLK-VKNMTKRAK--- ----------------------LKNVKAKSGLNK-SILDTSFYQFLSFVEYKAMHN--GK -VFTKIEPQY-T--SKA--CC-KCG--TI---KENLT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LKDR-V--------------F--TCDN------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-VEHRDINASKNILDRG--- -------------LKSFGLGT-------------------SLLDYKQEALRVS------- ---------- >IS1136 ------------------------------------------------------------ --FVRTAYRV----RAYPAP-------EQAAQ---------------------------- ------LG---------------------------------------------------- --------------------------------------------------RTFGCVRL-- ------------------------------------------------------------ -----------------------------VWN---------------------------- ------------------------------------------------KTLAERH----- -------------------------------------RAYHAHGR--------------- -KTSC----------------------READAALTAWKKTD----EPAFLS--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVSSVPLQQ-------------- TLRHQHT--------------AYANFFAGRA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RYPRFKP--------RN-GRQSAH YT---------------------------------------------------------- ---------------------------------------------RSAFR-L--RGGKLT LAKHTAPLE-------FVWSWDDETLATLNP----------------------------- ------------------------------------TMVIVSR--------------E-- -----------------------PDGRWYVTLAV-------------------------- ------------------------------------------------------------ ----DTDDPEPQPETGSAVGVDL-GVKD-FAVLST------------------------- ------------------------------------------------------------ --------------------------------------GEKIAN-------PKHLDR--- ----------KARNLARYQRQMARKQKG-------------------------------- -----------------------------------------------------------S NNRRKAKTK---------------------VAR---AH-REIRCARTDFLHR-TT---TN LV-----------------------REH--------D--AIAIEDLN-IAGMARSAK--- ----------------GTVAKPGRNVRAKSGLNR-AVMDAALGEFRRQLEYKTTRA--GK -TLVVIDRWYPS--SKT--CS-ACG--HL---LEKLS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSTR-A--------------W--TCPG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------RT-RHDRDINAAKNILAAG--- -------------RAVAGKTP-------------------GDACGADVSPQGS------- -SLRQSAVKQ >IS1341 ------------------------------------------------------------ ----NKAYQF----RLYPTK-------EQEQL---------------------------- ------LA---------------------------------------------------- --------------------------------------------------KTFGCVRF-- ------------------------------------------------------------ -----------------------------VYN---------------------------- ------------------------------------------------KMLEERI----- -------------------------------------QMFEKFKD--------------- -DQES----------------------LKQQTCPTPAKYKK----EFPWLK--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVDSLALAN-------------- AQLNLQK--------------AFQHFFSGRA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GFPKFKN--------RK-AKQSYT TN---------------------------------------------------------- -------------------------------------------MVNGNIK-L--SDGYIK LPKLKWIKL---------KQHREIPAHHII------------------------------ ------------------------------------KSCTITK--------------T-- -----------------------KTGKYYISILT-------------------------- ------------------------------------------------------------ ----EYEHQPAPKEVQTVVGLDF-SMST-LYVDSE------------------------- ------------------------------------------------------------ --------------------------------------GKRANY-------PRFYRK--- ----------ALETLAKEQRKWSRKKKG-------------------------------- -----------------------------------------------------------S NRWHKQRLK---------------------VAK---LH-EKIANQRKDFLHK-ES---HK LA-----------------------KRY--------D--CVVIEDLN-MKGMSQ------ ----------------------------ALHFGQ-GVHDNGWGMFTTFLQYKLVEQ--GK -KLIKIDKWFPS--SKT--CS-CCG--RV---KESLS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSER-T--------------F--RCE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-ESDRDVNAAINIKHEG--- -------------MKRLAIV---------------------------------------- ---------- >IS605 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VYN---------------------------- ------------------------------------------------YFLDYRQ----- -------------------------------------KQYAKGIK--------------- --ETY----------------------FTMQKVLTQIKHQE----KYHYLN--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ECNSQSLQM-------------- ALRQLVS--------------AYDNFFSKRA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RYPKFKS--------KKNAKQSFA IP---------------------------------------------------------- --------------------------------------------QNIEIK-T--ETQTIA LPKFKEGIK--------AKLHRELPKDSVI------------------------------ ------------------------------------KQAFISC--------------I-- ------------------------ADQYFCSISY-------------------------- ------------------------------------------------------------ ---ETKEPIPKPTIIKKAVGLDM-GLRT-LIVTSD------------------------- ------------------------------------------------------------ --------------------------------------KIEYPH-------IRFYQK--- ----------LEKKLTKAQRRLSKKVKG-------------------------------- -----------------------------------------------------------S NNRKKQAKK---------------------VAR---LH-LACSNTRDDYLHK-IS---NE IT-----------------------NQY--------D--LIGVETLN-VKGL-------- ---------------------------MRTYHSK-SLANASWGKFLTMLKYKAQRK--AK -TLLGIDRFFPS--SQL--CS-YCG--FN---TGKKH----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ENIT-K--------------F--TCPH------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------NI-THHRDYNASVNIRNYA--- -------------LGMLDDRH-------------------KIKIDKSRVGIIR------- -TDYAHYTDE >IS891 ------------------------------------------------------------ -----LVFET----KLEGTN-------EQYQL---------------------------- ------LD---------------------------------------------------- --------------------------------------------------EAIKTARF-- ------------------------------------------------------------ -----------------------------VRN---------------------------- ------------------------------------------------ACLRYWM----- -------------------------------------DNQNIGR---------------- ---------------------------YDLSAYCAVLAANE----NFPFVA--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KLNSMARQA-------------- SAERAWS--------------AIARFFDNCKQNKTGKK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GYPRFKK--------EQ-THGSVE YK---------------------------------------------------------- -------------------------------------------TSGWKLS-S--DRRYVT FSDGFKAGTFKLWGTRDLHFYQLKQF---------------------------------- ------------------------------------KRVRVVR----------------- -----------------------RADGYYAQFCI-------------------------- ------------------------------------------------------------ ----DQERVERREPTLKTIGLDV-GLNH-FLTDSE------------------------- ------------------------------------------------------------ --------------------------------------GNTVEN-------PRHLRK--- ----------SEKSLKRLQRRLSKTKKG-------------------------------- -----------------------------------------------------------S NNRVKARNR---------------------LSR---KH-LKVSRQRKDFAVK-LA---RC VV-----------------------QSS--------D--LVAYEDLQ-VRNM-------- --------------------------VRNRHLAK-SISDAAWTQFRQWVEYFGKVF--GV -VTVAVPPHH-T--SQN--CS-NCG--EV---VKKS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSTR-T--------------H--ACPH------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GH-IQDRDWNAARNILELG--- -------------LRTVGHTG-------------------SQVSGDIDLCLGE------- -VTPPNKSSR >ISMma22 ------------------------------------------------------------ ----LKVLRY----RVYPTK-------AQKTT---------------------------- ------MN---------------------------------------------------- --------------------------------------------------NTLELCRW-- ------------------------------------------------------------ -----------------------------TYN---------------------------- ------------------------------------------------ETLALRK----- -------------------------------------DAWESEQK--------------- -NIGY----------------------YDSKKMIPEWKK------EKPELK--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TVHSQVLQE-------------- VIKRVDL--------------AFQAFFRRVKTGEKA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GYPRFRG--------YG-RYDSFT YT---------------------------------------------------------- ---------------------------------------------QSGFS-L--DSDRLT LSKIGDIKI---------KLHRPVEGEI-------------------------------- ------------------------------------KRLNVRK--------------MP- ------------------------TGKWFVSFLV-------------------------- ------------------------------------------------------------ ----ETDTPLELQKTGLSVGVDV-GIKS-FLTLSD------------------------- ------------------------------------------------------------ --------------------------------------GNYVPN-------PRFFVT--- ----------EEKFLAKVQRKLSKLEKG-------------------------------- -----------------------------------------------------------T PERAKALKA---------------------VQR---VH-ERISNKREDFVQK-VS---LN LV-----------------------RNY--------D--LITFEDLN-IKGM-------- --------------------------IKNHKLAK-HIADVAWNKLVTITSYKAEWA--GK -RVELVNPCN-T--SQM--CS-GCG--EI---VKKE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSER-I--------------H--SCPY------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-TLDRDHNAAINIMRLG--- -------------LQSLQNSG-------------------RCPSLQ-------------- ---------- >YP_003686431.1 ------------------------------------------------------------ ----LKAFAY----RIYPTK-------PQLKD---------------------------- ------LE---------------------------------------------------- --------------------------------------------------EHLNRTRE-- ------------------------------------------------------------ -----------------------------LYN---------------------------- ------------------------------------------------AALQERR----- -------------------------------------DAYKKAGK--------------- -TVTA----------------------FEQMRSLALVKE------GRPEYR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RIHAHVLQG-------------- VITQLDR--------------AFQGFFRRVKAGEKA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GYPRFKS--------KD-RWNSFH FK---------------------------------------------------------- ---------------------QVWDNSR-------------DNWFGPGKP-V--GSNRIR LPNIGDVRIKWHRPLAGRP----------------------------------------- ------------------------------------KTLTIKR----------DGEHLST GASRGPM-----------------ALHWYAVYVC-------------------------- ------------------------------------------------------------ -----EVEPQPLPATGGEVGIDL-GVNPNFLVTSD------------------------- ------------------------------------------------------------ --------------------------------------GEFVPA-------PHYYRK--- ----------TEAKLRRQQRVVSRRKRG-------------------------------- -----------------------------------------------------------G GGRKKAVAA---------------------LKR---LH-RKVRNQRKDFHHK-TA---RK LL-----------------------EAN--------D--VVYHENLS-VKAM-------- ---------------------------SRSRLSK-SILDMGWGQFLNILYGKAAEA--GR -RVVSVNPAY-T--SQI--CS-GCG--HV---QKV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PIGK-P--------------Y--ECGA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-VIHRDVNAALNILRMG--- -------------QGLPLGES-------------------DEVAHARRPQKPP------- -ALAVG---- >ISCARN6 ------------------------------------------------------------ ---LNRKVTY----RLYPNV-------EQEAR---------------------------- ------LQ---------------------------------------------------- --------------------------------------------------ETLGLHQR-- ------------------------------------------------------------ -----------------------------LYN---------------------------- ------------------------------------------------TALEERI----- -------------------------------------RVYKETGK--------------- -GLSF----------------------VDQCKVLTQWRKVVPALA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GLNAQSEQV-------------- TLKRLHL--------------AFQHFFRRVKNGET------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------PGFPRFKN--------IH-RYPGWG YK---------------------------------------------------------- ------------THGDGWKLHSSQGASP-------------SQGANHGEN-C--AHGKLY LQGLGHIPIRGKARTAGTP----------------------------------------- ------------------------------------VTCEIIH----------------- -----------------------KTGRWYASVTL-------------------------- ------------------------------------------------------------ -----EMENIQRACGTEMGAFDW-GLKE-FLTVAT------------------------- ------------------------------------------------------------ -----------------------------------PQGIETVTN-------PRHLRN--- ----------QLAELKRLGQEVARKIHMAQKL---------------------------- -----------------------------------------------SGRQRGFPI---S ANLRRAIQH---------------------LAK---LH-AKVARQRKDFMHQ-AS---AR LV-----------------------KRF--------G--AIGTEALA-VKNMVH------ -----------------------NGGAHKKGLNR-EIHAAAPATFLKMTRTKAEEA--GS -WYEEAPTRE-IKPTQR--CH-ACW--KL---PDEKKT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSNR-E--------------H--QCPH------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GV-TCGRDENAALVLLRWL--- -------------EMRLAGGS-------------------GSGREPSEMWSGG------- -SFAAMKHET >IS608 ------------------------------------------------------------ -----ITYKQ----KLYKN--------DKNRR---------------------------- ------ID---------------------------------------------------- --------------------------------------------------TLLRRYGA-- ------------------------------------------------------------ -----------------------------LYN---------------------------- ------------------------------------------------HCIALHK----- -------------------------------------RYYRLFKK--------------- -YLKL----------------------YDLQKHITKLKKTH----RYAFLK--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TLGSQTMQD-------------- LTERIDK--------------AFKKFFNKKA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KLPRFKK--------VA-NYKSFT FK---------------------------------------------------------- ---------------------SKIDKKT-------------GLNKGVGFA-I--KDNVVS FN---------------------------------------------------------- --------------------GYSYKFIKTYAFIGKVKTLTIKR--------------DN- ------------------------TGDYFLCLVC-------------------------- ------------------------------------------------------------ ---ELENHPNKQTACDKSVGFDF-GLKT-FLTGSD------------------------- ------------------------------------------------------------ --------------------------------------HTKIES-------PLSFSK--- ----------YLPLIKRLSKNLSKKVKG-------------------------------- -----------------------------------------------------------S NNFKKAKKK---------------------LTQ---LH-QKIKYLRTDFFHK-LA---LK LS-----------------------REY--------Q--TIFIEDLN-MKAM-------- ----------------------------QKLWGR-KVSDLAFSEFVKILENKA------- -NVVKIDRFYPS--SKT--CS-NCL--FV---NEEINKDFRKIGKT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DKER-E--------------Y--HCKY------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-ELDRDLNAAINIHRVG--- -------------ASTLGVEF-------------------VRPTC--------------- ---------- >IS607 ----------------------------------------------------------S- --AISITHKI----ALKPNN-------KHITY---------------------------- ------FK---------------------------------------------------- --------------------------------------------------KAFGCARF-- ------------------------------------------------------------ -----------------------------AYN---------------------------- ------------------------------------------------WGLAKWK----- -------------------------------------ENYQLGIKTSH------------ ---------------------------LQLKKEFNALKKS-----QFNFVY--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVTKYATQQ-------------- PFIHLNL--------------AFNKFFRDLEKGLV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SYPKFKK--------KREFQGSFY IG---------------------------------------------------------- -----------------------------------------GDQIKIIQT-A--NTDYLK IPNLPPIKLTEKLRFQGKI----------------------------------------- ------------------------------------HNATITQ----------------- -----------------------KGDHFYVSISC-------------------------- -----------------------------------------------------------D IDESEYKRTHKLQESHNKLGIDI-GIKS-FVSLSN------------------------- ------------------------------------------------------------ --------------------------------------GLNIYA-------PKPLDK--- ----------LTRKLVRISRQLSKKIHPKTKGDKTRK----------------------- -----------------------------------------------------------S NNYLKHSKK---------------------LTH---LH-EKIANIRLDFLHK-LT---SS LI-----------------------RHS--------N--SFCLESLK-VKNM-------- --------------------------FKNHRLAK-SLSDISMSVFNTLLEYKAKYS--NK -EILRADTYYPS--SKT--CS-NCQ--KV---KQDLK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LKDR-I--------------Y--QCLE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-ELDRDINAAINLLKHL--- -------------VGRVTAEF-------------------TPMDLTALLNDLS------- -NNRLATSKV >EFT53053.1 --------------------------------------------ITEPATPKLDKNDPD- --VVVRSYKF----ALRPTT-------SQERK---------------------------- ------LR---------------------------------------------------- --------------------------------------------------QHTGAARF-- ------------------------------------------------------------ -----------------------------VYN---------------------------- ------------------------------------------------YLISQWR----- -------------------------------------DDILIRAEEKERGVPEDGLTPFT FKLSA----------------------YDMRNYWNRTKGE-----CAPWWP--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVSKEIGND-------------- AARRAHD--------------SIENWHDSRGGKRKGRRV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GFPRFHK--------RG-CHESCT FS---------------------------------------------------------- -------------------------------------------TGTIRVN-P--DRHSVA LPRIGTIKTRENTRELQRKIAKGTARI--------------------------------- ------------------------------------TQATISR----------------- -----------------------GFNYWHVSFTM-------------------------- ------------------------------------------------------------ --YEKKHIPETHAHSGSVAGVDM-GVGD-HVIVAA------------------------- ------------------------------------------------------------ --------------------------------TPNGDEIMRRGL-------PQSVTK--- ----------DEARVRHLQRKLSRKHGPDKRTKTTP------------------------ -----------------------------------------------------------S NRWIRANNQ---------------------VRK---YR-NTMANVRRDLAAK-TA---HG LA-----------------------KNY--------E--TVVIEDLN-VQAMMTR----- ------------------------GGAHKRGLNR-AIAQASFADLRRRITYKTRWN--GG -TTIVADRWFPS--SKT--CS-ECG--EV---KSKLS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSER-E--------------Y--ICHR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GV-AVDRDLNAATNLAKLA--- -------------APKSGVDF-----------------HGTGSSPGMGRGGAG------- -KTSSPSGEL >ISBlo12 ------------------------------------------------------------ --SAYEAVRI----RLDPTP-------RQTRL---------------------------- ------LE---------------------------------------------------- --------------------------------------------------SHAGGARF-- ------------------------------------------------------------ -----------------------------AYN---------------------------- ------------------------------------------------LMLAHVR----- -------------------------------------RQISLGEK--------------- PDWTL----------------------YAMRRWWNEWKDE-----IAPWWR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ENSKEAYGS-------------- AFEWLSQ--------------ALRNWSDSRKGRRAGRRVGW------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PKYKS--------KRSSVPRFA YT---------------------------------------------------------- ------------------------------------------TGSFGLIE-D--DPKALR LPRIGRVHCMENATERVHGRRI-------------------------------------- ------------------------------------VRMTVSR--------------H-- ------------------------AGFWYAALTV-------------------------- ----------------------------------------------------------ER PTESVPAKNRKRKNHDRQVGVDL-GVRT-LATLSD------------------------- ------------------------------------------------------------ --------------------------------------GTTFPN-------PRNYVR--- ----------TQRKLRHAQQSLSRRDRG-------------------------------- -----------------------------------------------------MSHGCGS KRYNRALER---------------------VRR---IH-ARIAAQRADNIGK-LT---TW LA-----------------------DNY--------S--DISIEDLN-VQGMSH------ ----------------------------NRRLAK-HILDADFHEFRRQLEYKTARA--GT -RLHVIDRWYPS--SKT--CS-NCG--TV---KAKLS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSER-V--------------Y--HCEE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-VIDRDVNAAINIQVAG--- -------------SAPETLNA-------------------RGGSVGQTRLECG------- -TMRHPAKRE >ISC1316 ------------------------------------------------------------ ----TLGFRF----RAYTDE-------QTLRA---------------------------- ------LK---------------------------------------------------- --------------------------------------------------AQLKLTCE-- ------------------------------------------------------------ -----------------------------IYN---------------------------- ------------------------------------------------TLRWADI----- -------------------------------------YFYQRDGK--------------- -GLTQ----------------------TELRQLALDLRKQDDEYK--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QLYSQVVQQ-------------- VADRYSE--------------AKKRFFEGLA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RFPKEKK--------PH-KYYSLV YT---------------------------------------------------------- ------------------QSGWKILHVR-------------EIRKGKKNK-K--KLITLK LSNLGTFKV---------IVHRDFPLDKV------------------------------- ------------------------------------KRVVVKL--------------T-- -----------------------RSERIYITFVV-------------------------- ------------------------------------------------------------ -----DHEFPKLPNTGKVVAIDV-GVEK-LLITSD------------------------- ------------------------------------------------------------ --------------------------------------GEYFPN-------LRPYEK--- ----------ALWKVKHIHRELSRKKFL-------------------------------- -----------------------------------------------------------S NNWFKAKVK---------------------LAR---AY-EHLKNLRTDLYMK-LG---KW FA-----------------------EHY--------D--VVVMEGIH-AKQL-------- ------------------------VGKSLRSLRR-RLSDVGFGELRGVLKYQLEKY--GK -KLILVNPAY-T--SKT--CA-RCG--YV---KNDLS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSDR-V--------------F--VCPN------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GW-IADRDYNASLNILRGS--- -------------GSERPLVW-------------------SSALYQYSGKVGL------- ---------- >EES54015.1 ------------------------------------------------------------ ----QTGKRF----RAYPTP-------AQEKI---------------------------- ------LL---------------------------------------------------- --------------------------------------------------RWIGHQRF-- ------------------------------------------------------------ -----------------------------IYN---------------------------- ------------------------------------------------AKVSEDR----- --------------------------------------YYRAFAK--------------- -KAVS----------------------LSGTPVPVDQEYARFIGPETSWLR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVPSPILRN-------------- GAVRWKQ--------------AYARFFSGLARR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PTFKG--------KD-GRQSVW IT---------------------------------------------------------- ------------------------SELF-------------SFRTNDETH-C--EELILG TKKFPLGVLSFKAQTPYSRP---------------------------------------- ------------------------------------ASLHVSV----------------- -----------------------EAGKWFVSFSS-------------------------- --------------------------------------------------DDGLPEPKEE DTISWLRMLSEEELEGKTLGFDR-GVVT-PVMVSS------------------------- ------------------------------------------------------------ ----------------------------------GRRIDFSDIQ-------KSRMEK--- ----------KERSRKRWQRKLARQQKG-------------------------------- -----------------------------------------------------------S QNRKKTKRR---------------------LSR---SF-EYVKNVRKDVIHK-AT---RD FV-----------------------SDS--------DRTLFVVEDLK-VKHMTR------ ---------SPEPKKDESGRYVRNGARAKAGLNR-AILASCWGLFVVLLSYKARRA--GK -LVLKVSPQF-S--SQE--CA-RCG--HI---HPDNR----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PSQA-G--------------F--VCQR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-TDNADHNASRVIAKRG--- -------------IRLLLEGN-------------------APGAGSENSKR--------- ---------- >ISBlo15 ------------------------------------------------------------ --ATEDGQQV----PLYSTNPDVV------------------------------------ ------MR---------------------------------------------------- --------------------------------------------------WLCDGWRC-- ------------------------------------------------------------ -----------------------------RYN---------------------------- ------------------------------------------------QLRSRRT----- -------------------------------------KWDRESQTAVPLNGRPDMRSDRQ ARLEC----------------------SWLT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AMPAMVLQS-------------- PNRIENT--------------DWWSANKRRRTLKKKHRNPGMM----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PRFKS--------RHDDLYFVC WH---------------------------------------------------------- -------------------------NKG-------------SNANYRRLN-R--HHGEVV IT---------------------------------------------------------- -----------------GQNPGEYRLDGQPCRYSIHIRVRVSQ----------------- ------------------------PIRDYTSIGV-------------------------- ------------------------------------------------------NWTRRT LVFVNDPLPIGRERTGAMVGLDR-GCAH-TLATSD------------------------- ------------------------------------------------------------ -------------------------------------NRFLDLP-------KQRLER--- ----------IDREIRRRQKAQARRVNMSGKTVREYRRNP-------------------- -----------------------------------------------------------S RTYERTGRE---------------------ISR---LY-AKAHRIIDDWQHK-TT---SM LV-----------------------HDY--------D--LIGLEDLN-LQGMSRKA---- ---------KAKPDPDRPGAYLHNGQSAKHGLNH-ALRSAGLAGIVEKLEYKTRLT--GQ NRLILVNPAY-T--SQT--CS-ECG--YC---DSRNR----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ESQA-D--------------F--ECKQ------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------HM-SMNADLNAANNILKRG--- -------------LNHLIGLD-------------------EAEHARTEPDAQP------- -AYRGKDASA >ZP_06965611.1 ------------------------------------------------------------ --FMLLCKKI----KLDLSE-------QDMAT---------------------------- ------LE---------------------------------------------------- --------------------------------------------------FMQGKCRG-- ------------------------------------------------------------ -----------------------------LYN---------------------------- ------------------------------------------------WWVMKLR----- ----------------------------------------------------------DG EKWRF----------------------NACKKTLAESRAYDPELN--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QVYGKLLAE-------------- VYYRLDG--------------AMRAFFRRVANGET------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PGFPR--------VRPRHGFFT LC---------------------------------------------------------- -------------------------------------------HPAMYLT-L--EGNMLM LPTGGKGKHKRFPAIRAHLTEEPPEGF--------------------------------- ------------------------------------REVAISR--------------DG- ------------------------RGNYYASFSY-------------------------- ------------------------------------------------------------ ------REPEQAKRDGNTVAFDL-GIKT-LATGVT------------------------- ------------------------------------------------------------ ----------------------------------EEGRIYHIGG-------FKGSRW--- ----------YNKQLDRLRSKRSKCKKK-------------------------------- -----------------------------------------------------------S RRYLHLSKV---------------------YKR---VS-QRKRNKQRDSLHK-AS---HL IA-----------------------RRL--------VERTVVVGDLS-QRQM-------- --------------------VMKEHQERNKALNRAVYNDWGLYAFVQMLKYKCQRY--GK -ELQFVDERN-T--SKQ--CS-GCG--NL---HAMP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LWKR-T--------------Y--QCAE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-VMDRDENSAHNILTRF--- -------------LARRGPYT-------------------QARPERDVLQATQ------- -SGVEVMGTS >ISDka1 ------------------------------------------------------------ --RVARTIVV----ETPPIPR------RLFRV---------------------------- ------------------------------------------------------------ ---------------------------------------------------FAELEG--- ------------------------------------------------------------ -----------------------------MYR---------------------------- --------------------NMVEQ-----------------------LVLHAVR----- -------------------------------------EGVPSFTR--------------- --LKA----------------------LKYRELRSLYP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QLPSHYAYT-------------- ACQDASA--------------RAKSFLRLKKKGLVEREH--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PEVDS--------VSIWLDDHL WR---------------------------------------------------------- ---------------------------A-------------NGLTSIEVA-T--HNGWIP LE---------------------------------------------------------- ----------------VIPHKQYWKYVNKGWRLASEAKIKLDR----------------- -----------------------KSRKLLVYLTF-------------------------- ------------------------------------------------------------ ------AKEVEEYKPRGYVSVDV-NEDN-VTVLID------------------------- ------------------------------------------------------------ ----------------------------------GVAYLFETNM-------KRVVLG--- ----------YYYRRKRVQEKYDVVYGTN------------------------------- ------------------------------------------------------------ --FSRKKRI---------------------LRK------LKEKKKKDDARWK-IA---SI IV-------------------REAFKRR--------Y--AIVMEKLG-KRPGEKMV---- ------------------------SRIRDSQLRH-RVFQASFKGVQRAIEEKAREY--GV -PVIYVDPKN-T--SRL--CP-VHG--SK---IVYG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DESR-I--------------G--KCER------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------G-------------------------------------------------- --------------------------------------GE-IWHRDVVAVWNLLLKT--- -------------LRGGGSSA-------------------PSPAGLPVDGSPV------- -PLGSTAAHE >ISTko2 ------------------------------------------------------------ --TIKLTAKF----KLKNPPE------E-------------------------------- ------LN---------------------------------------------------- --------------------------------------------------DLFSTYRE-- ------------------------------------------------------------ -----------------------------IVN---------------------------- ------------------------------------------------HLISYAF----- -------------------------------------ENNVTSFY--------------- -RLKK----------------------ETYKSLRKEYP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ELPSHYHYT-------------- ATQMATM--------------IYKSYRKRKKKGKANGR---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PVFKK--------DAIMLDDHL FK---------------------------------------------------------- ------------------------------------------------LD-L--EAGVIK LSTPSGRVELEFYPSKYHEKFRDWKI---------------------------------- ------------------------------------GQAWLVR----------------- -----------------------TPKGVFINVVF-------------------------- ------------------------------------------------------------ ------SREVEVREPEAFVGVDL-NENNVTLSLPN------------------------- ------------------------------------------------------------ ----------------------------------GEFVQILTHE-------REIRTG--- ----------YFLKRRKIQKKLRTRKK--------------------------------- ------------------------------------------------------------ -----RKEL---------------------LEK---YG-QRERNRLDDLYHK-LA---NK IV--------------------ELAERY--------S--GIALEDLT-EIRDSI------ --------------------------RYSAEVNG-RLHRWSFRKLQNIIEYKAKLK--GI -KVVFVNPAY-T--SSL--CP-VCG--RK---LSP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NGHR-V--------------L--KCPK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-EADRDVIGSWNISLRA--- -------------LKMWGVSV-------------------PPESPTMKTGVGK------- -VGRSDVYEL >YP_319874 ------------------------------------------------------------ --PIRATVSM----KIGLSDS------LLA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------FVN---------------------------- ------------------------------------------------NYVRALR----- ----------FSI---------------------FWMKENVKNPNEKGTLSKVHEGLYGK LKEDY------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NLPPKVSAD-------------- CYRDALA--------------IYKSWYNNPKRGRFP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RVYKP--------TVWLTPKRS YT---------------------------------------------------------- ------------------------------------------------VD-L--DRMVVK ITSVGELPILGYPRNLKEYANWDM------------------------------------ ------------------------------------KEARLTI----------------- -----------------------RDGKAFLKVVF-------------------------- ------------------------------------------------------------ ------EKPKVKIQPKGSVAVDI-NMSE-IVVGKD------------------------- ------------------------------------------------------------ ----------------------------------DSHYVRIPTR-------LHESHH--- ----------FKTLAENLQKKYPRRWKEN------------------------------- ------------------------------------------------------------ ---KRILHR---------------------IRS---FH-HKAKLIMEDFARK-VG---KW VV------------------EIAWDLGA--------N--VIKLENLK-NLIRNVN----- --------------------------KLSAEFRD-KLYLMQYHRIQYWIEWQARKH--GM -NVEYVNPSY-S--SVS--CP-KCG--RK---MVE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------IAHR-Y--------------F--HCPS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-ENDRDVIAIMNLNGRG--- -------------SLTLSTAP-------------------QMRDVIPNR----------- ---------- >ISC1904 ------------------------------------------------------------ --YVHFTYSI----KNDKREE------SKELIKEYTTL---------------------- ------LQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KAIDYLW----- -------------------------------------SLTKIQVRKNGNYKITLPKKKEV YKPLR----------------------DELEKIN-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HLASHYVDK-------------- AINDAFS--------------ILKSWRKRAIKGRASIEK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PRVKK--------AYVRIKTTL RK---------------------------------------------------------- ------------------------------------------------VV-G--ESVRIT VR---------------------------------------------------------- ------------------PYEYITFSWSKSWFSRRVRELELGEP---------------- ---------------------IIKEEKVYLPFRY-------------------------- ------------------------------------------------------------ --------KLPWATPLNFLAIDS-NLYT-LDAYDG------------------------- ------------------------------------------------------------ ---------------------------------EKFVTISLKQL-------YSLKYS--- ----------MEVKRAKVQSFASKHTKR-------------------------------- ------------------------------------------------------------ -----GREL---------------------LRK---YS-HRERNRVLDFVHK-FV---NA LL-----------------------DLY--------PMTFFAVEKLN-KESM-------- ------------------------FVDANDSLSR-KISRTVWRSIHRVLKYKAPLY--GS -FVKEVNPRF-T--SRS--CP-RCG--FV---SR-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KVGK-T--------------F--ECER------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-KLDRQLNASLNIYLKM--- -------------CGFPHIRD------------------IARVWVGVIPLMGR------- -RG-MNGFPR >ISDge19 ------------------------------------------------------------ --KITLTAKL----KLRHTP--------EQKKA--------------------------- ------LD---------------------------------------------------- --------------------------------------------------AVTLAYRD-- ------------------------------------------------------------ -----------------------------ALN---------------------------- ------------------------------------------------FTSQKAF----- -------------------------------------EMGKTSNAAKIQREVYATLRERF ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GLGAQMACS-------------- VPRYVGA--------------VYKTLWAKAKQSKAAREVNPKAKRYKGLDNA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PKFVS--------RTLSYQYQR DY---------------------------------------------------------- ------------------------------------------------SF-K--KGQQVS ISTLNGRVVLPYEGYAKHLEYIAQGAEIGA------------------------------ ------------------------------------GKLWYSK----------------- -----------------------AKKQYFLLVPL-------------------------- ------------------------------------------------------------ ---TFELPDPDPMTHKQVVGVDV-GMRY-FATASN------------------------- ------------------------------------------------------------ -------------------------------TSGKALFKSGKAT-------LRKAER--- ----------FQKARKSLQQKG-------------------------------------- ------------------------------------------------------------ -----TRSA---------------------VRRLVQLS-GRERRFIAETNHA-IA---AE IL-----------------------SRF--------PNAFIGVEELT-GVRDRTERRS-- ---------RKNSS------------EKTRKANR-RRARWSYAELLSFLAYKAPLH--GS -MVVKVDAHY-T--SQT--CP-RCG--HC---SRENRP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------HKGL-M--------------F--ICES------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-QLHADLVGARNIGLRA--- -------------LLVRQDWA-------------------STGCLSCTPGRPQ------- -SADPQAGSA >ISNph22 ------------------------------------------------------------ --EVRRTVPV----SLDVDSD------DAALLEDTVDT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------FLWSAQYVVDHAFE---------------------------- ------------------------------------------------------------ -------------------------------------GEYVTTSKTTLDDETYDDVREKT D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EFNGGLVQA-------------- ARNKAAE--------------ACKSVVARWKNDKKASK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PTFTS--------PHVVYDHRT AT---------------------------------------------------------- ---------------------------------------------------F--HDDYVS LATTDGRIEADYVLPDEDSDTPHSEYLFSDEYET-------------------------- ------------------------------------TGAELHS----------------- -----------------------HDGDWVLHVHC-------------------------- -----------------------------------------------------------K KEVESDTSEQPTTENGTVLGVDL-GVNN-LAVAST------------------------- ------------------------------------------------------------ -----------------------------------GTFWTGDEF-------DHWRRE--- ----------YEKRRGSLQQCGTRWAHEN------------------------------- ------------------------------------------------------------ ------------------------------IQS---VG-RKEEGRFKQMLHR-IS---NE LV------------------SEARENEC--------S--VIAFEDLT-DIRERT------ -------------------------------GAS-WGHKWAFNRLYDYVEYKAEEY--GI -SVEQVDPEN-T--SRR--CS-HCG--FT---HPDN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RDDE-D--------------F--ECLK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-ENHADYNAAKNIGLRY--- -------------LRRNQTGG-------------------DGGAPLGVRLNSG------- -TLNVNGGYS >YP_516804.1 ------------------------------------------------------------ --LIIRVYKL----PFRTSQD------NLNRLYACNRI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SAQIWN---------------------------- ------------------------------------------------QCLDLAK----- -------------------------------------EHGQRTNTWLSRKELHLATKGRY ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PIHSQSIQA-------------- VYEKYLD--------------ARENALQARALGYTQ------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------IRYPY--------KEKHHFNTR WK---------------------------------------------------------- --------------------------------------------KDGFRI-G--EKGRIE LS---------------------------------------------------------- ------------LGLWEGKRQKPITVRVAHCPPGQIKEIELVY----------------- ------------------------DRGLKLAMAF-------------------------- ------------------------------------------------------------ ----EDGISPKANPAQGTAAIDL-GEIHTLASVTD------------------------- ------------------------------------------------------------ --------------------------------QGQGLLITGRKL-------RSIKRL--- ----------RNKKLKELQRKMAHCQKG-------------------------------- -----------------------------------------------------------S RQWKKYRRA---------------------FHY---VL-SKSEAQLTDALHK-TT---RE FV------------------RWCLDNAV--------K--DVVIGDVE-GIQRHTSPKK-- ---------KQTQR------------KRSRRINQ-NLSQWTFGKTRRYLQYKLAAE--GI -SLKKVDEAY-T--TQT--CP-VCG--KR---RV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PSSR-T--------------Y--HCG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-VQHRDLHGAGNILTQH--- -------------LYGHYQAI-------------------VLKDYKYLRIA--------- ---------- >YP_003570103.1 ------------------------------------------------------------ ----YLTRKF----HIEGTEQ------LERLSRSSAD----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LWN---------------------------- ------------------------------------------------SVCKWYW----- -------------------------------------RTVDRQDHWISKTAMRRWHCKGH D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VLPSQTAQE-------------- VAGQFYE--------------AIGSWHDNDRKGNPPKRCD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------KTYNV--------LRWTYQGVT LR---------------------------------------------------------- ------------------------------------------------------EDGVLR LSTKRGEDSILIDWPVDEEP---------------------------------------- ------------------------------------RTVEIGK----------------- -----------------------ASDGFVVRAQY-------------------------- ------------------------------------------------------------ -----DREPVDRTTGDKVAGVDL-GEKH-LAAVFT------------------------- ------------------------------------------------------------ --------------------------------GDDAFTINGGEL-------RALRHY--- ----------QNSLKAKLDAKIDRKERGSNRWKKLVET---------------------- ------------------------------------------------------------ ------------------------------KRK---QL-DHIDNKIMDLLHK-LS---RK VV------------------EMLLERRV--------S--AVGIGDVR-GIRDRI------ --------------------------DYGTKMNQ-RLHQWVYGEFARMIEYKAELA--GI -TVERIDEAY-T--SQE--CP-KCG--HR---KK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PSGR-E--------------Y--TCSE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------SF-HGHRDVAGAANIRRKY--- -------------VGQEPTGS-------------------KTRLPGVMASPLG------- -VRFRPHLSC >ISNph5 ------------------------------------------------------------ --TATTTKTL----EATLAPP------TAHKERKLCDL---------------------- ------LD---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TYR---------------------------- ------------------------------------------------AGLHEAF----- -------------------------------------EAGCETMTATSDVVTPY------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------DLPYQAKAA-------------- LCNYVPQ--------------LHGTYDAQELDDDHPVRLTNQA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AEFDH--------SPERDYEFT WW---------------------------------------------------------- -----------------------------------------------VPQPGRGTNFWIP LRINPAQEELWHDIVDGEASA--------------------------------------- ------------------------------------GQLRLQR----------------- -----------------------HRTSWTLHVTV-------------------------- ------------------------------------------------------------ EFPVKEPGYEPTDDDVTPVGFDI-GEAH-LLAGCA------------------------- ------------------------------------------------------------ ---------------------------CEQGTPTDPLLINGGRA-------RHLRKE--- ----------MHTTLKRLQERDAAEWR--------------------------------- ------------------------------------------------------------ ------------------------------IDE---RF-DHYQNALTDIIEK-AS---RQ AI------------------EYACRFEK--------P--VVVLEDLS-YIREDL------ --------------------------DYGEWMNR-RLHAWAFARLQERIEDKARES--GI -PVEYIRPEY-T--SQT--CH-ECG--HI---GY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RDGD-E--------------F--RCQN-DE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------WVSEYHADINAAVNIADRH--- -------------DPWGESLP-------------------LKPAGDDISRDGS------- -ACDSAATPT >ISFac11 ------------------------------------------------------------ --QDVIILKL----KIDNDKLN-----NNTIKA--------------------------- ------LN---------------------------------------------------- --------------------------------------------------TIFLEAKW-- ------------------------------------------------------------ -----------------------------LYN---------------------------- --------------------YVINKEFNNDIFNIDPKIKNVQVYVIDHYETRKLK----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------YLSSQMKEE-------------- IINRAMD--------------NIRGLHKLKEKGLKIGK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LKFKS--------FITSIPLNQ YT---------------------------------------------------------- ---------------------------------------------ITYKI-I--NNNYIK IQNIKQLLK--------------------------------------------------- ----------------------VNGLDNLECYYEPASALLIN------------------ -----------------------KNSNYYINITA-------------------------- ------------------------------------------------------------ --YKNKYILEKPVNNQKIISFDL-GIKN-QLTCSN------------------------- ------------------------------------------------------------ -----------------------------------------GSI-------LNYNIP--- ----------KSRKEIRLQRSLSRKAKYAEGTKKLSRGQ--------------------- -----------------------------------------------------------S RNYYKNKNK---------------------LNK---EQ-NKTMNKRKDTINK-IT---HY LT-----------------------SNY--------D--IVVTQNDN-IRGW-------- ----------------------------KYLFGK-RIESTGIGGIIDALKHKA------S -TLILIDRFIPT--TKE--CS-KCH--NK---YDIK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LDER-I--------------Y--QCHN------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-IIDRDYNSSLNMIYYG--- -------------TIKLNELL-------------------KIKNKKLNNYFKK------- -YNINLNVPM >CRv-1 ------------------------------------------------------------ --KFLCCKTI----EIYPNL-------EQKNI---------------------------- ------IL---------------------------------------------------- --------------------------------------------------KWMDLFIN-- ------------------------------------------------------------ -----------------------------MYN---------------------------- ------------------------------------------------HTNYFIN----- -------------------------------------NNIYDFTNRKIKSNVKEILNFRK LRDNY----------------------IKNKKNETCKD---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EINKHMLDE-------------- AINHCVS--------------KHKSCITNYFSKNIKF----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------FRIRN--------MKKNRRKKI LI---------------------------------------------------------- --------------IEKGLFSKKKNGFC-------------LTKLQEIKS-S--ESIGVN ------------------------------------------------------------ ------------------------------------KTSILQY----------------- ---------------------DKHLNKFTLFIPI-------------------------- ------------------------------------------------------------ ------EKNTTNIENRTKCGIDP-GIRT-FLTCYS------------------------- ------------------------------------------------------------ --------------------------------KKEILEIGENCY-------EKYKN---- ----------NYKKIDKTRELFDKK----------------------------------- -----------------------------------------------------------E INKKQFTKS---------------------INH---NF-DKIRNLTKDLHFK-VS---SY LC-----------------------KKF--------N--IITIGKIS-TSSIVLN----- ------------------------TNNLNKISKR-CMLSLSHFKFREILEYQCNKY--NT -QLNIVDESY-T--TKT--CS-NCK--EL---NNI------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GSSK-K--------------Y--QCKS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------NF-KCDRDINASINIYLK---- ------------------------------------------------------------ ---------- >ISvMimi_1 ------------------------------------------------------------ --VFISSEKI----RIYPTK-------DQQKI---------------------------- ------LQ---------------------------------------------------- --------------------------------------------------TWFRLFAY-- ------------------------------------------------------------ -----------------------------MYN---------------------------- ------------------------------------------------CTIDYIN----- ------------------------------------------SKKVVLESGRINVAATRK VCNKI----------------------SVRKAQKTIRDNLIQSTNP-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SIMTHIIDE-------------- AIGLACS--------------NYKTCLTNYIERHIKK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------FDIKP--------WNMSKRKKI II---------------------------------------------------------- --------------IEANFFKKGTFCPT-------------VFP----KM-E--SSKPLT MID--------------------------------------------------------- ------------------------------------KTVTLQY----------------- ---------------------DSDTRKYILFVPR-------------------------- ------------------------------------------------------------ -----VTPKYSVNKEKNSCGIDP-GLRD-FLTVYS------------------------- ------------------------------------------------------------ ------------------------------ENETQSICPIEIVV-------NTTKN---- ----------EYKKIDKINEIIKT------------------------------------ ------------------------------------------------------KPNLNS KRKKKLNRG---------------------LRK---YH-RRVTNKMKDMHYK-VS---HE LV-----------------------NTF--------D--KICIGKLN-VKSILSK----- -----------------------ANTVLKSALKR-KLATLSFYRFTQRLTHMGYKY--GT -EVVNVNEYL-T--TKT--CS-NCG--KI---KDL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GASK-I--------------Y--ECES------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GM-YADRDENAAKNILKVG--- -------------LKPWYKQK--------------------------------------- ---------- >ISvMimi_2 ------------------------------------------------------------ --GFIRSRRI----QLLPND-------FQKNI---------------------------- ------FN---------------------------------------------------- --------------------------------------------------IWFNETTV-- ------------------------------------------------------------ -----------------------------IYN---------------------------- ------------------------------------------------RLLTEFT----- -------------------------------------QYYIKFKEIASDNKELVKLLRTN EEFPL----------------------SLQKLRNLKIHDIINIYLEDQLIHKL------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ETPFCVIAN-------------- TIKEFVA--------------NVKGNLTKLAENKIDKFT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------FKHKN--------FNGKIRTIS ID---------------------------------------------------------- ----------------SKYASENSFYPD-------------KLGKLLQTY-E--DLKGFS WKNVK------------------------------------------------------- ------------------------------------HDFKIVY----------------- ---------------------DKYNNKYYAHIPK-------------------------- ------------------------------------------------------------ ----YVYRNLNILNKKPITVMDP-GERT-FQTLYG------------------------- ------------------------------------------------------------ --------------------------------LDHVISIGDNLR-------ETISK---- ----------RLLRIDNLKSKLDTPGSKKHNLK--------------------------- ------------------------------------------------------LNRKTR VRKCRYKKA---------------------IDR---HH-KKIEHLQRELHYK-TA---IY LC-----------------------ENY--------Q--RIMVTDFS-SKKVSSK----- ------------------------DGDLDAMSKR-ILGKISHYRFRQRLQQKCEEF--NC -QYLEVNEAW-T--SKT--CC-NCG--YI---HAKL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GTSK-I--------------Y--DCPK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------KQ-KRDRDVNGAINILLKN--- -------------RKLVLMED-------------------Q------------------- ---------- >ACa-1 ------------------------------------------------------------ --FNGKMRKI----CVFPMA-------QQKTL---------------------------- ------LK---------------------------------------------------- --------------------------------------------------CWIGTVRW-- ------------------------------------------------------------ -----------------------------TYN---------------------------- ------------------------------------------------QCVAVVC----- -------------------------------------RWQCAPTKKALRAHFVTEFGLRE VEQIK----------------------RAKSGVGSGGNNNNVGISWVF------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KTPHDLCNQ-------------- AVGQFVT--------------AYKNAVQAHGWGKFD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------IAFWL--------AKRLQQEMV VI---------------------------------------------------------- --------------RSRDWNRTRGEYAP-------------IFGNTMLRS-S--ESLPAK MD---------------------------------------------------------- ------------------------------------HEFQVTR----------------- ----------------------TKLGWYYISIPV-------------------------- -----------------------------------------------PLDVKHPIQQQQP DAVGGGDNQAPAVAPHAAAAIDP-GVRT-PFMVYS------------------------- ------------------------------------------------------------ ------------------------------PDEARVYELGANDF-------GRIRR---- ----------LCHHLDDLVSRMT------------------------------------- ------------------------------------------------------DRDVRK KRRRRMRRA---------------------AAR---MR-RRIRDLVDDLHWR-AA---KW LC-----------------------ETF--------E--TIIYPHYE-TSNMVVGKSK-- ------------------------RRGLHSKTVR-AMLTWSHFWFKQHLLHKIREYPSGC -RVVLVDESY-T--SKT--CG-GCG--RI---NHGL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GKSK-L--------------F--WCEQ------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-RTDRDWNGARNIWLKF--- -------------LTEWCNGS-------------------SRGNDDDDKEQQQ------- -QQQQ----- >ACa-2 ------------------------------------------------------------ --YDGKCRKI----RVFPNR-------WQKDL---------------------------- ------LK---------------------------------------------------- --------------------------------------------------SWMGTVRW-- ------------------------------------------------------------ -----------------------------TFN---------------------------- ------------------------------------------------ACNAAVR----- -------------------------------------AGLSGHSEAELRSRFVDNEAFGK PSRRK----------------------KKKAKVAAPFSERGKELLAATRHLPGPSTLWVL ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------DTPRDIRDQ-------------- AAKELSA--------------AYKNGTKAHGKGKFE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------VKFKS--------PKKMAQQCI TS---------------------------------------------------------- ------------NARDWGRGRTSVFHGL-------------FDSGRALRA-S--EPLPRE MK---------------------------------------------------------- ------------------------------------HEFKIVR----------------- ----------------------TRLGRYYLCVPM-------------------------- ---------------------------------------------------------DLE TRGESQAPSSSDDVGAECVFIDP-GVRT-FVTTFD------------------------- ------------------------------------------------------------ -------------------------------LSGRIHEFGTGSI-------GRIEK---- ----------LCRRLDDLISRTYAKKPDDRQ----------------------------- ------------------------------------------------------RFLRGK KKRWRMRRA---------------------ALR---MR-RRIRDLIDEAHRK-IA---LW LC-----------------------ENH--------R--VILWPLSG-VSNMVVAK---- ---------EDLKQ---------RKRRIGAKSVR-AMLTWSWYRFQEWLKHKVREFP-WC -RLVLTSEAH-T--TKT--CT-HCG--TP---NHDV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GRSE-V--------------F--RCAD-AA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------PNRSAHRDHHGARNNGLRF--- -------------LTEWANLP-------------------TTTTTTTMTQRLP------- -TRVIDLTTS >ISArma1 ------------------------------------------------------------ --TKLRSKKI----RIYPSP-------ELNQV---------------------------- ------WR---------------------------------------------------- --------------------------------------------------KWLAACRY-- ------------------------------------------------------------ -----------------------------CYN---------------------------- ------------------------------------------------QAIALSR----- -------------------------------------------------------SGKRL SKLKL----------------------RNKVMQSDLPEWVK------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ETPCHIRQN-------------- AIFDAYQ--------------ALTASPG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ARFRS--------CRDSSQGIK FN---------------------------------------------------------- ----------------NTNFSSGSWYPR-------------LTKGLTFMV-S--EPIPKT CG---------------------------------------------------------- ------------------------------------QGTQLVF----------------- -----------------------TKGRWLAIFPE-------------------------- ------------------------------------------------------------ ------PVAVTPTDATGVIALDP-GVRT-FITGFD------------------------- ------------------------------------------------------------ --------------------------------GSRFLELGSGDI-------GRITR---- ----------LCQHLDDLMSRI-------------------------------------- ------------------------------------------------------AKEPCR SRRRRMRQA---------------------AQR---MR-TKIRNLVDEAHKQ-IA---HY LT-----------------------HNY--------S--IIFLPTFE-TSDMVAK----- -----------------------VKRLIRSKTAR-AMLTWAHYRFKLTLRHQAEIT--GT -TVVDVTEEY-T--SKT--CT-HCG--HV---HSQL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGSK-V--------------F--RCPE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-TLPRDWNGAFGIFLKA--- -------------LRDTASVT-------------------LTGNSAIVALSGN------- -SRINVA--- >YP_001658372.1 ------------------------------------------------------------ --TLKKSKKV----RIYPTT-------EQKKL---------------------------- ------MK---------------------------------------------------- --------------------------------------------------HWWGVSRF-- ------------------------------------------------------------ -----------------------------VFN---------------------------- ------------------------------------------------QTIKYLQ----- -------------------------------------EPDRKANWKAIKTGIINDLPEWA K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVPYQIKSI-------------- AVKDACE--------------AVKNAQRKYQKTGEIQK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------VKFRS--------RKDKQQSCY IP---------------------------------------------------------- ----------------KSAISEKGIYH---------------TKLGQIRF-T--ESLPDN F----------------------------------------------------------- ------------------------------------GDSRLVS----------------- -----------------------RNGQYYLAIPH-------------------------- ------------------------------------------------------------ -----EVQRCESDNQGRIVALDP-GVRD-FLALFS------------------------- ------------------------------------------------------------ --------------------------------PNSFGSIGSQDI-------GKIQR---- ----------LCYHLDDLISR--------------------------------------- ------------------------------------------------------STKVNA KTRNRYRKA---------------------SNR---LR-NKIRNLVDELHHQ-VA---RF LV-----------------------DNF--------D--VILLPTFE-VSEMVLK----- -----------------------NSRKIRSKSVR-QMLNWSHYRFKQFLKHKAFEM--GK -LVIDCCEAY-T--SKT--VS-WTG--EL---IHNL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGKK-V--------------I--KSKI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------D-------------------------------------------------- --------------------------------------GK-TMDRDINGARGIFLRA--- -------------LGDTPSLR-------------------DSLRVHC------------- ---------- >NP_490252.1 ------------------------------------------------------------ --TNRKSVKVCTQYRMILTL-------EQEQL---------------------------- ------LM---------------------------------------------------- --------------------------------------------------KWVRLNRK-- ------------------------------------------------------------ -----------------------------TYN---------------------------- ------------------------------------------------MAIAYLN----- -------------------------------------------QKQGFDRTGIGGTGKQA FKTFF----------------------KAHIRPDWLKN---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ELPAAILDQ-------------- AVMEAYS--------------AWSTTQRHPKTISKGKDKKPHPQAGLKI----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AKFRS--------IRDSSQTLQ FK---------------------------------------------------------- ------------------------------------------------IA-S--DLNKGR LL---------------------------------------------------------- -----------PQYWGELPAFECVDNGVRFCPISNPYTPEVTY----------------- -----------------------KHSRFYISLPE-------------------------- ------------------------------------------------------------ ------DVEVVDNNKDAFIAFDP-GVRT-FLTGFD------------------------- ------------------------------------------------------------ --------------------------------GQKMIEFGNGDI-------HRIVR---- ----------LCQWLDKLRSFRDLS----------------------------------- ------------------------------------------------------KGFKNR HLRYRLSQK---------------------MKR---VT-RRIRNLVDEMHRQ-VA---SW VA-----------------------KNY--------R--VIALPTYE-TSQMVCR----- -----------------------AVRKIKSKTAR-SMLSFAPYRFSQVLEHQCTRN--GS -VLIRHTEEF-T--SKT--CS-RCG--HI---HYSL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGQK-I--------------F--KCSN------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GN-HLPRDWNGALGNFLKA--- -------------LWDTTLLN-------------------SASFDCVQMTVFV------- ---------- >ISvAR158_1 ------------------------------------------------------------ --KAMISRKV----EIFPNV-------KDAMV---------------------------- ------LK---------------------------------------------------- --------------------------------------------------RWCGLYRR-- ------------------------------------------------------------ -----------------------------MYN---------------------------- ------------------------------------------------LAIEKML----- ----------------------------------DTGRWHWKGHKVLTTYDNIPKNEKVR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LLPTNIRKE-------------- AYREAST--------------AMAKAPHKNT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------VKFKT--------LKRNGRSLR VF---------------------------------------------------------- ------------------------------------------GAVSIVDT-P--DGKRIK LTDSQKHKQLSKELIGFDQKNL-------------------------------------- ------------------------------------ADIRIGS----------------- ------------------SSQIVYDGKWWLLSPF-------------------------- ------------------------------------------------------------ ------EVERSNVPKKHAVALDP-GVRT-FQTTYS------------------------- ------------------------------------------------------------ -------------------------------PDGTSKKLGDQAS-------CRIFR---- ----------LMKYIDKLAVFKDKRTRGK------------------------------- ------------------------------------------------------------ ------------------------------RLR---LE-RRVGNLVDEMHWK-IA---RE LA-----------------------TDY--------D--TIIIPPFE-TQKMAKK----- -------------------WKNGRYRKINKTAVR-MMLRLAHYRFRERLIHVANKL--GT -RVVICTEEY-T--SKT--CG-NCG--VV---NADL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GSAK-K--------------F--KCPR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------HI-HVDRDGNGARNILIKS--- -------------VCC-------------------------------------------- ---------- >SCe-1 ------------------------------------------------------------ --NIKTLRQM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LIN---------------------------- ------------------------------------------------KDINILE----- ------------------------------------------------------------ ----------------------------------PHEQWLK------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EYNYDLKSE-------------- ALRDLVK--------------NYSSNMARYKSTGTPFK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LKFKS--------EKAKTQSLS VL---------------------------------------------------------- ---------------KKYWNNKKSFYSD-------------VFSSTKMRS-A--EKLPEQ LL---------------------------------------------------------- ------------------------------------MDSRLQR----------------- ----------------------TRHNHFYLIVPM-------------------------- ------------------------------------------------------------ ----VGEEIARDEGREKFIFIDP-GVRT-FLTGYD------------------------- ------------------------------------------------------------ -------------------------------SGQNVVEIGKNAV-------VRTEK---- ----------LKHRRRKLQSKL-------------------------------------- ------------------------------------------------------AKLKTH KKRQNHRKA---------------------LHR---LD-EKISRILSDMHKK-SA---LC LC-----------------------KSY--------E--TVFIPKLN-FHQC-------- -------------------------TKLNRKSRS-SMATMAHCSFNDRVVMKAEQLR-GT -SVIVVEEDY-T--SKT--CS-KCG--NI---KKDL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GSNK-I--------------Y--SCVS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------FS-VFDRDFNAAKNIMLKY--- -------------CCEHLMTS-------------------DASSVPLPLVERV------- -RGSP----- >AGo-1 ------------------------------------------------------------ --DHWTPKTV----RIYPTS-------KQKEI---------------------------- ------LH---------------------------------------------------- --------------------------------------------------LWLTATRH-- ------------------------------------------------------------ -----------------------------MYN---------------------------- ------------------------------------------------LAVAERI----- -------------------------------------RLGKEAKENGTKVKMKLKHLREV MPLKK----------------------NFDYERDPKLTYLK------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NVPFLIKDN-------------- GLRDFDK--------------DYRTNLAKSKNTLRPFK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------IHFKK--------IKDKQSMTV EK---------------------------------------------------------- ----------------KVWGLSRGIYHD-------------VFRKGAFRS-T--EPLPEQ LP---------------------------------------------------------- ------------------------------------HDSRLIR----------------- -----------------------EHGKWFLVIPY-------------------------- ------------------------------------------------------------ ----ETSGLMPKKEAINAVAVDP-GVRT-FLTTYD------------------------- ------------------------------------------------------------ -------------------------------SSQRVLEIGEDGY-------LKLQH---- ----------LDRRLRSLQSEIHKLRSKGIVL---------------------------- ------------------------------------------------------SKEDRK RKIRNRRTV---------------------ISR---LY-QRKKNLANDVHRK-AS---HL LA-----------------------SKY--------N--YILIPVLN-FHNF-------- -------------------------KKTNRRVKA-NLANMKHCLFVQRLKNKASHFE-NT -TVIEVDEEF-T--TKT--CS-LCG---V---RSNI------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GASK-V--------------F--KCDN------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------DA-TFDRDHNAAKNILLKY--- -------------LGEID------------------------------------------ ---------- >ISvNY2A_1 ------------------------------------------------------------ --HVIATRII----KIRPTK-------SQKQQ---------------------------- ------ID---------------------------------------------------- --------------------------------------------------KIAGVVRF-- ------------------------------------------------------------ -----------------------------CYN---------------------------- ------------------------------------------------ASINEIN----- ---------------------------------------KMRCHEISWPSGKLDQHLRNK FSIGK----------------------HNDIEQYISIHGNNIEPEQIIETTKMNTETRKK EPSRRYINPFFLGKLWLS------------------------------------------ ------------------------------------------------------------ -------------------------------------ECPKDFRAR-------------- ATFKAAD--------------AYKTSLTLWRKGLIRSFE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MKFST--------KRRELDRGY CF---------------------------------------------------------- -----------------------GIEKK-------------VKFEDTGLK-K--RDGKLI ITGIDGDIRFFEKPPINKEPV--------------------------------------- ------------------------------------AGCELSK----------------- ----------------------DSCGDYYLHVPI-------------------------- ------------------------------------------------------------ ------FRKKKERKGDNFVAIDP-GGVV-PWAFYA------------------------- ------------------------------------------------------------ -------------------------------SKGESGCLGTEMN-------ERMSN---- ----------VSKKISTIDKKLSGQ----------------------------------- ---------------------------------------------------------PKG DKNSNDVIE---------------------RRK---LF-RKKKRIRDHEHYR-VI---NF LT-----------------------DRY--------D--GIILPKLK-TKNISK------ --------------------------ALKSKANH-DMFDISHYTFLRRVGERCIES--DT -ILEHPGEQW-T--SKT--CG-RCG--KS---NLPGRERR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GTFR-E--------------Y--KCLY------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-HAHRDVHAARNIFMKW--- -------------YIELKK----------------------------------------- ---------- >ISvNY2A_2 ------------------------------------------------------------ --KVLRTRKV----KLNPTK-------QQKLM---------------------------- ------LM---------------------------------------------------- --------------------------------------------------KYANAARY-- ------------------------------------------------------------ -----------------------------SYN---------------------------- ------------------------------------------------IAIAAVN----- -------------------------------------DKTHKANKIELQNAFLSLKRRDD GSYNQ----------------------FFQKRRWLL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ATPQPIRQQ-------------- AIFEAAK--------------NFKAAFTNLKNKNIDHFK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MKFKT--------KKHQRQHGF SI---------------------------------------------------------- ------------------------------------------GIGTHLKH-N--DGVLSI LPRSLGQMRYFGSLPFEGKPD--------------------------------------- ------------------------------------AECRIQR----------------- ----------------------DPYGDHWLLIPV-------------------------- ------------------------------------------------------------ ------YKITKTQTTKPIVAIDP-GVRT-PFACFR------------------------- ------------------------------------------------------------ -------------------------------SDGDSKCIGEDMN-------AKLVD---- ----------IKTRVSIVDRRISKC----------------------------------- ---------------------------------------------------------QDV ALKRKLREH---------------------RRV---LF-RKHQRVRDAYHWK-II---ND IT-----------------------DEC--------S--GVLLPPFE-TQRVSR------ --------------------------MLKAKTNC-SMLGISHYTFRMRMKDKCEEK--GL -LYDEPTEEY-T--SKT--CG-VCG--LI---NYLL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GSKK-I--------------F--ECF------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GN-VCDRDVHAARNILLKW--- -------------LSSEAGAR-------------------VAETFLASRSS--------- ---------- >SAl-1 ------------------------------------------------------------ --PVEHDRAV----RSLKDKQVVADTKHRHFL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HALQALKTMLLN ELQEFQACRRAAK---------------------SRKEALAEEHAAKQEALAEEHAAKQE ALAEE----------------------HAAKQEALAEEHAAKQEALAEEHAAKQEALAEE HAAKQEALAEEHAAKQEALAEEHAAKQEALAEEHAAKQEALEKHQQREVADLEQRQVQEI RDCTLTDAYARKIADVHRSTWLMTKK---------------------------------- -------------------------------------GMAVSSWTG-------------- SILEFHT--------------ALKTQQQRQEENDT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------FKFHM--------SRQAARNTI PV----------------DAVNLKQTRGMFAVMCVDKLRVAEPLPAAKDFRGQARFTLDA SGRYHICVASNFTRGAPDDVGTLGQSLL-------------QVERPVLAG-C--DDGLQE VEEEEEARAKCEEHGGGDMAMQALEEKARVRERKMGEVARRLQAEAREARR--------- ------------------------------------RWVRLRR----------AKAIDKQ TQEAEAEFQAARERHAAHLDWRRRLRKRRRLLRM-------------------------- ------------------------------------------------------------ ----KERNALLRERRGGVVSIDP-GVRV-PFTLWT------------------------- ------------------------------------------------------------ --------------------------------ASGTVSIAHDAI-------EELRM---- ----------LLRNANDIRADADLLEVAVQ------------------------------ ------------------------------------------------------EGEARG EGDVAAARR---------------------RHR--QQL-RVVRDRVDHLHRV~VA---NY LV-----------------------MSF--------R--VVLLPRFG-TSRMIRRS---- ------------------------GRPFGRDTAR-SMGVWAHYRFRQLLLDRAEREP-GC -TVVICDEAW-T--SKT--CG-RCG--RL---HHSL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GADD-V--------------F--ACPH-DS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------RY-VAGRDANAARNILLLW--- -------------LYRNDIQL-------------------APVPAP-------------- ---------- >ZP_07091981.1 ------------------------------------------------------------ --HVLLTDKQ----KIQHEKALKTQNA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LFQ---------------------------- ------------------------------------------------YALKYLFKTYGV KHIGRPMPFS------------------------QKPIQYVLNKIKTGFIKDKYGLARWK KSV----------------------------------------L---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------FLSSHSADE-------------- FLKTVYT--------------NFSQYRKRLVKADKSMDEKARYNFKMNVTK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------DKYGK--------HKNQLHKSW YR---------------------------------------------------KGSINFL RNSASFRTITSQKLPEDSKGGIRIEDKH-------------TDNHTFLTV-A--DFGTVE VIEDLSELNL-------------------------------------------------- ------------------------------------KDIALT------------------ ------------------KIKKLPDGSYRLQLTF-------------------------- ------------------------------------------------------------ ------SLPRKKQKSKTIQGFDW-NMAGNEAFCSS------------------------- ------------------------------------------------------------ --------------------------------DGKRIKVSDAAI-------KRADE---- ----------YEQKINAIKSARDLEGNAHGQ----------------------------- -----------------------------------------------------------S KLYRKLDRR---------------------QQK---LN-AKRSNMLTNEYRH-LV---HE VV-----------------------DDC--------D--TIVVEKLD-AYEMRKRGKGS- --------------------------AQRKGINR-RLAVLKPYELMTILESLVKKQ--NK -RFVKVDSFW-T--SKA--CH-DCG--YI---NKDLK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VGQK-E--------------W--QCPS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------KK-TVDRDLNAARNILDWGIHP EHHAK--------LKKTAEEG-------------------KNLSPSSLVTEV-------- ---------- >ISTvo5 ------------------------------------------------------------ ----KRANAV----KLIVGKETHEKLKELAIV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AAKCWN---------------------------- ------------------------------------------------EVNWLRM----- -------------------------------------QQFKEGERVDFSKTEKEVYEKYK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QILKVNTQQ-------------- VARKNAE--------------SWRSFFSLIEEKKGKLPKWFKPRP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PGYWK--------DKSGKYKML II---------------------------------------------------------- -----------------------------------------IRNDRYEID-E--EKRIIY LKDFKLSLSFNGKLKWRGKQ---------------------------------------- ------------------------------------GRLEIIY----------------- ---------------------NEARRSWYAYIPV-------------------------- ------------------------------------------------------------ -----EVQNDVKAEDKLKASIDL-GIIN-LATVYV------------------------- ------------------------------------------------------------ -------------------------------EDGSWYIFKGGSV-------LSQYEY--- ----------YSKRISVAQKTLARHKQGR------------------------------- ------------------------------------------------------------ ------SRE---------------------MKL---LH-EKRKRFLKHALNS-MV---RK IM-----------------------EEF--------K--NKGVGEIA-IGYPKEISKDHG -------------------------------NKL-TVNFWNYGYIIRRFEGVGEEL--GV -KVVKVDEAW-T--SKT--CS-LCG--EA---HDDG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RIKRGL--------------Y--RCLR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------I-------------------------------------------------- --------------------------------------GK-VINADLNGAINILHIP--- -------------ESLGAGSR---------------------GQLTVRDRGNG------- -LKTQPAVYR >ISNph17 ------------------------------------------------------------ --QRTNTYTA----NATSDRYRQCLFDWLAAQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPLWN---------------------------- ------------------------------------------------QITYRRR----- -------------------------------------QAYFSDDGDVWDADYTDLYDEYA P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------IIGKATCQQ-------------- IARKNSE--------------AWRSHFRLLEQYHDNSNTTVTEKPSPPGYWGNRKEGYEL HGLVRNDLYTLDWDEDRSTLEFGVGDVLK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------DRYDF--------EHNERVTLE IK---------------------------------------------------------- --------------------------------------------GNPQWN-G--DDSRLE LI---------------------------------------------------------- -------------------------------YDDHADQLRVQ------------------ --------------------HPVRIQPDKIREQRED------------------------ ------------------------------------------------------------ ----AFTHTLNTENTTQAAAIDV-GANN-TLAVVT------------------------- ------------------------------------------------------------ ------------------------------ERGDTAVYHARPEF-------ARFQR---- ----------YSERIATLQSGLPADKYTSSL----------------------------- ------------------------------------------------------------ -----IQRL---------------------YDT---RS-RSRDHSRDAAVKH-VA---EW LL----------------------ERNV--------D--TVYVGDLT-DVLDTHWSTDV- -------------------------------NEK-THNFWSHRQLLNRIELTLGDV--GI -CVAEVTEAD-S--SSE--CP-ECG--SS---DIT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RRGD-S--------------F--RCHD------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------EL-DAHSDVAGAWNILQSE--- -------------AGPMARPA-------------------ALSAERDRDAPQE------- -GAYWQWNEH >NP_613890.1 ------------------------------------------------------------ --YRYRSITL----KIVGPEGYRRDLIFLSDR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------CTAVYN---------------------------- ------------------------------------------------ELNYLRRRFFFK GKLDAVAVSRSEL---------------------TFRRIYREYGP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ILGTQTVVA-------------- IGEKNTE--------------AWRSYFKQIKEVKSNKRRTICQPPRYWKGPLGRE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PRFVF--------LASQIRRFE YD---------------------------------------------------------- ------------------------------------------------PL-E--HRGVIE ILGLGDVVD--------------------------------------------------- ------------------------NLPNVGFKRGRGRGVRLEFVGWFPWHPNRVKEPKRA DKIILNGDDGKEFFGRSEIVYSWADNAHYLTLNM-------------------------- ----------------------------------------------KVNKGESWLVSRLT PNGRVRPIPRTGNNCENAAAVDI-GRRI-FAAVYF------------------------- ------------------------------------------------------------ -----------------------------SDGKKPVLVRWGDAW-------SRWSYW--- ----------RKIKAPKEQRRLNKNGANF------------------------------- ------------------------------------------------------------ ------SHR---------------------LKQ---YY-VKAHRAIMDAIRH-LV---SK LV------------------QILLSREV--------T--LLVIEDLK-GLRQK------- -------------------------------LHG-ELAYWAYKRIIREIKRKCEEY--GI -EVIEASPAY-T--SVT--CP-MCR--SK---CK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RNGG-L--------------V--ICSK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GK-TMNADIVRAYNLLTRATDD PPEPELEYLTGSNCTTVLPSN-------------------HKPPITPNR----------- ---------- >ISTvo1 ------------------------------------------------------------ --KVRRTEQI----YLKENDTISYMCHLSKN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LYN---------------------------- ------------------------------------------------QVNYILR----- -------------------------------------QQFLKGEKLTGYRDLVKLFQEPS EIEDH----------------------NNYQ----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RLPAQTAQW-------------- TVKKTVM--------------AWYSFFKSMKAWKKHPD---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KFKG--------RPRLPGYKE TDGE-------------------------------------------------------- -------------------------FLL--------------VFTNQQCR-I--RDGILK FPKIMNMEVKTRLNENEIKL---------------------------------------- ------------------------------------KEVRIV------------------ ----------------------PQGTGYMIEIVY-------------------------- ------------------------------------------------------------ ---EKETADMPITKPKRAMGIDI-GVRN-LVTIGN------------------------- ------------------------------------------------------------ ------------------------------NIHEIGIAVKAGLL-------KSINQY--- ----------FNKELARYRSINDLQGNERKQTVK-------------------------- ------------------------------------------------------------ ------------------------------IRK---LF-MKRNRKVKDIMHK-VS---KS IV------------------EYAKIMNI--------D--TIVIGHNN-RWKDSSNMGKK- -------------------------------NNQ-NFVQLPFNMLIYQIKYKAEEI--GI -TVIMQNEDY-T--SK---CS------FL---DNESIEHHDTYMGK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RIHRGI--------------F--RSAT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GK-LIHADLQSSYNIIKKA--- -------------IPEAFANG-------------------IEGIGLYPRSLSI------- -RQMITSKGG >YP_004034605.1 ------------------------------------------------------------ --TKTQPKTV----RVYSKKI------SDEEFARMSDF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------FERYGRCRHFFLNRYCGIKSM LAVNNWQALRNQVRKWDKPVKGSKGKLETVYNFQTKHWVGALREACANIKSMWS------ ------------------------------------------------NLANRLK----- -------------------------------------KLIQGNENLSADQRHLLFFILKF KSAWQAVLLHKPIELPEEY----TEVLT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EIEAKLTDK-------------- QIKQAHS--------------YLRRITYR------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------YHYRA--------RKSGKLGSS MK---------------------------------------------------------- --------------------------------------------CDLNWA-F--EGNTFS FSSDVPRKQFSVEMTSPWSYPRT------------------------------------- ------------------------------------GDITVV------------------ ------------------------LERIKQRLEV-------------------------- ------------------------------------------------------------ --HKLISSKRYSNDSKKAIGIDK-GLAT-LLSCNS------------------------- ------------------------------------------------------------ -------------------------GNEYGKNFSKLANAIVDKY-------GKRNA---- ----------NRQPYMSLRWQLNQQLEQLEKA---------------------------- ------------------------------------------DKPLSKTALRKKRKLLGK LKNLEQNNI---------------------GRK---SY-DKSYRSAQETVRSFISCAINR MI-----------------------EKE-------HPA-VIAKEDLT-FVKEKGVKS--- -----------------------DNSRLARKMRK-RLNSWTKGQLDERIVYLSSKN--SI -ETHDVNPAY-T--SQY--CP-ICG--QH---FEERYG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHHELT-----------------RCKK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------G--EMNANIAAAKNILSRL--- -------------TDEEITLY------------------------TPYKRVKE------- -ILASRIKEA >YP_003589585.1 ------------------------------------------------------------ --FGLQARQW----KLALEDALWTLERQWE------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AAIAEVR----- -------------------------------------DRLHRNGGLTPKERDYAFWLLDK FGDRP----------------------RDWRKIEAVFRDEDLA----------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GKKTELEPA-------------- GRKKIRH--------------GLKRLFRRVLGKR-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PRVRK--------ARSFVVDQQ MY---------------------------------------------------------- ---------------------------------------------RVFMV-G--NRQYVA VMGLSPGKRIVIPLSGIHKLR--------------------------------------- ------------------------------------GNLRVV------------------ ------------------------LLPDEQAVEIH------------------------- ------------------------------------------------------------ ----MSREPKTYPAGEEEAGIDL-GVTE-VLTDDS------------------------- ------------------------------------------------------------ -------------------------GKKYRPEYGQALQEMSDHM-------LDKGR---- ----------KRQKLWALYRKNRERDPGKARR---------------------------- -----------------------------------------------------------I RRHNLGLVK---------------------QHK---RH-RRYRAWCENEINR-AL---RA FF-----------------------RER--------RPRVIAYEDLS-HLRGKAR----- ----------------------------NKGLSR-KVSQWQRQAIRERLEYLCHVY-SIT -DPGPVNAAY-T--SQTCPCP-GCG--WV---DGKN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RNGD-S--------------F--RCQK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-EGDADHVAATNVKGRLRDQ E------------ITKYTPHK-------------------EVKRILLKRYWEN------- -HA------- >ISCARN12 ------------------------------------------------------------ --IRKEISAS----RLYADLPVDGTIRNETTK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------DIVNDVLLYK---------------------------- --------------------------------------------------AAAMQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KVRKAIAAR-------------- THDETER-------------KRLYTLLRKDQWLTDNFLHRQRR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------KHFRH--------GKSQVANQF I----------------------------------------------------------- ------------------------------------------------VR-S--DKYTTE IVNGYLTIVIHIAAKYGENIRLTTTSSG-------------------------------- ------------------------------------KNVRLS------------------ -----------------GSNLRIIVKDGFSEIHY-------------------------- ------------------------------------------------------------ ----ATAKGDGRPCGEKMIGIDK-GYTE-AFMDSE------------------------- ------------------------------------------------------------ -------------------------GVPHGKDFGKVMRVYSDQT-------MITGK---- ----------ARNRLHALEKKHREAGQIAKADHI-------------------------- ----------------------------------------------------------RD NNLGRIKLN---------------------ARK------DRTHKQLRTIAFQ-SA---HA IV-----------------------DKA--------A--VVVSEDLT-AFMALQQAW--- -----------------------------KRYNR-RMSAWAKGVLAEALDSVCTQR--QA -EHCLVNEAY-T--SQM--DS-VTG--LL---EGKR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VGDK-F--------------Y--RVN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GD-VLQADHNAALNVLARYEDT E------------ITRFTSHA-------------------EVRRILLARSPAQ------- -LSVKGHELQ >YP_001213061.1 ------------------------------------------------------------ --TATTLMQK----EALERPLETPLPSAYVQI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AGN---------------------------- ------------------------------------------------RMLDILR----- -------------------------------------EHYLAVQDKITSDVWKDRNLSME YRLVC----------------------SVFVRNATLFHRFVNGLTEAEDVVAEWRASKSE RLRKVA------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EAYDSFSPQ-------------- ARAGIEG--------------FITARFREIRAAWRV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PAFRG--------GVIQLDYRV FA---------------------------------------------------------- ------------------LEEARGTKEF-------------NLWARVTTA-V--SHRRIA VP---------------------------------------------------------- -------------LRLTAEKRRLLDSLFPDWLKSTARKAQLV------------------ ----------------------VRGRHIRLSVPV-------------------------- ------------------------------------------------------------ ----AKPRVEPKGEPEAVLGCDI-GMAA-LLNLSN------------------------- ------------------------------------------------------------ -------------------------GVKLGKSFKGIAGKLYDEY-------LRLQG---- ----------VRNKIRGLRQRAEKRLSVTKNPETR------------------------- ---------------------------------------------------HRLERKIAE YDRHLSDHR---------------------WVV---LR-RRIKAAVSTEIGR-AV---NQ FL-----------------ALLGPNPER--------V--LVVMEDLS-EMAAEGARQ--- -----------------------------SSRARFDLSVWARGELQDHLKRDLEWL--GG -RVAFVPPEY-T--SQT--CP-ICG--WV---DKEN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RRGR-E--------------F--RCRC------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GF-AADADTVGALNIGERFSDA E------------LLALAERY-------------------WYSRDLRREKIKE------- -LLLARAENA >YP_002425507.1 ------------------------------------------------------------ -------------MRTYPYSHAANAVKERQIW---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------DVLRAYR----- -------------------------------------QSAQRIANDQWKSLFITGSMEKD GSICP----ADH------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------IISKRYLQT-------------- CQRQVVG--------------VLKSWLSNRKNDFRMLVIHSSLWKDKTEDGERLRIQLLF INKHGLWFKDRVVMRKEVIPAHVMRLARNLFRRLMNKHNK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PSFRH--------VGMALDAKV AR---------------------------------------------------------- -----------VEAPNKAHSAEFPYWLTLATLNPRKPIHIPLHENPYALA-A--DGDEKA FVQINVRRGTAIAGQL-------------------------------------------- ------------------------------------GALDIA------------------ --------------------------RIKESAP--------------------------- ------------------------------------------------------------ ----VFSLERPRPQIVDTLGIDV-GLRT-LVATSM------------------------- ------------------------------------------------------------ -----------------------------------GELLGRNLI-------DRLSR---- ----------LDAQISRLAAERQRQRLPVH------------------------------ ------------------------------------------------------------ ------SRR---------------------YDT---LV-NRMRSFLKNEIGR-VL---NG LF-----------------------ARV--------HPAKVVIESLD-FRSP-------- --------------------------DLSRRLNR-LVQNFGRTWFRQKLDMLSEEY--GF -LVEEVHAAY-S--SQT--CK-SCD--YV---AKNN------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RSSQSK--------------F--HCRF------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GR-KAHADPNGAEVIRQRR--- -------------SLPEYAP---------------------WRSKRQILQATV------- -GRFLKR--- >ZP_05025755.1 ------------------------------------------------------------ --KNLMKRTA----RVYLNDL------NVSKF---------------------------- ------LI---------------------------------------------------- --------------------------------------------------VREFLG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QCHSIM------ -------------------------------------QYFVDLFWQRQDFSGKLADLPTV HRAKKKF----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GITTRLGQA-------------- LAKQASE--------------CVFSVHQKQRKRK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PQLKW--------HTVTLFYHF VT---------------------------------------------------------- --------------------ISPFKKKG-------------FDWCVKLIG-S--GAPKLV IP-----LKSTSVINQRLAQGWQMS----------------------------------- ------------------------------------KTIRMGL----------------- -----------------------KKGRLWIDFIF-------------------------- ------------------------------------------------------------ -----EKVRPPLKTQGRVVGMDS-NYKN-GVVFSD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------SQVVGQDIYQRIQE------------------------------------ ------------------------------------------------------------ ------------------------------------FK-KRQKNTHAEIKSR-LG---QA LK-------------------KVDLSST--------K--VLSIEDLK-KVKQGKRG---- --------------------------TFSRLFNR-RLSHWLYRTLVQLLERKCEEE--GI -QLVVKDPFK-T--SQF--CS-NCN--RW---DRRNR----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KGDR----------------F--RCVH------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GY-QSHADHNAAHNRRAFR--- -------------LGGSLWSP--------------------FLLKFKKSKFWI------- -TIETSLKPC >ZP_06970586.1 ------------------------------------------------------------ ------AKALKTLRQALHYPPQYADYFAANQL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LFN---------------------------- ------------------------------------------------RVVAFYV----- ----------------------------------EVIQAHEGILSLKNKEALTTLARLTH ATEKNPRPIVPLSDLAP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------DVPAMFRRA-------------- AINAALG--------------SARAFFSSLNTWRARKERHEAKAGTTGKKKQPFRERPPV P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PRTWN--------KSAPFYAGL WK---------------------------------------------------------- ------------------------------------------------------ERTSHS ITLKVWTGSRWSWLKIGTLSRELPDGFEM------------------------------- ------------------------------------GSPHLV------------------ ----------------------RKGARWWLHIPI-------------------------- ---------------------------------------------------------EKT FEAPANVREQLTTGEKRICAVDL-NLDQHLAVCSV------------------------- ------------------------------------------------------------ ----------------------------QTVDGTILATSFIGNG-------TAIAGC--- ----------RKKLLGRIARNRSQTG---------------------------------- ------------------------------------------------------------ -ILAEGEQD---------------------NVA---LW-RKIRHLDEHIAHQ-VS---AR IV------------------QFALKQHA--------S--ILVFEHLG-SLRPAKGR---- ---------------------------YSRRGNL-KRAYWMKGRIFRYSKYKAWNA-GGI -ITCRVNPRN-T--SRE--CH-RCH--GL---VIRYQEGEPVEGYT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PGAPLC-----------------LCPQ------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------QM-RGHADRNASLNIGQRL--- -------------LKRMQDPL--------------------KEKPHACSRRAT------- -REPKGSGVG >MDe-8 ------------------------------------------------------------ ----SQKRTCPSLQQVILGTRTNILCISFSQA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TYRRGPHKE---------------------- ------------------------------------------------AILAAIN----- -------------------------------------KRVITMTRIAYHGSTVALFKCKK ALEEGNFAFFNDLKNIRDCFLHVSVAKDVHGNIEDYTRNLHDDVRNCFTEFNIEPPSTEA LGNVEPYAVNQYIT---------------------------------------------- ------------------------------------------------------------ -------------------------------------NFADNIRMH-------------- FKKRLKT--------------FFFARTRRN------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PLLFPDITPQVIHDTVSYMTNALA-----RGVEPN IDLIHEIPNWNQFNISDEYVQQNQGFFEKKLLGTGKDERWFRTVIMFLGMQMEIDDYQEW CRAHPELELG-MLKNF-------------------------------------------- ----------VVVP--------LHKLKRQHIRIDTEAFYWLLRELKLIPETPGKIHKEKA K-------------------------------------FMEDR--------ERVKHWYNW FDKE-------------------------------------------------------- -------KIRKMEKGGNFFHFQ--------------------------IV-T--NGLGAS VLFTRVNQQSSNKPDN-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -YMESIRQKLESGHYKRVIGMDP-GYKV-WISAVI------------------------- ------------------------------------------------------------ ---RYLRTGQEFNYDVTSRQFHKFTKKKKREKKAKRLTGDFENRRKADAENRELYPAGI- ---------PSPNRRENWFDYIRWRFKWCNEGFDLYTDIQ-------------------- ------------------------------------------------------------ ------------------------------YAR---LD-LDQHFRTQKVMDR-MV---NK LV-----------------------GND--------PA-LVCIGSTN-FNPSAPIKKHI- --------------------------------------RCPGTKMI--LQYLKKKT--KV -DILLIDEFN-T--SQV--CG-HCH--SF---FDREWQDRHEN----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RGRRFK-----------------QCTV-AN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------CQIRFPNPIGPTNVIVAKKNHRKIQQERRAFPIVAEHPEGQPEQDPKKSTH QFLKTKYNKIRPYPEGPKPKYVCNVQNNDWGLVTQRGNSKITWNRDTSAARNILYKG--- -------------VCAVLKIP----------------IHPNFVRPPRMNRALT------- -QAEKQARKF >MDe-6 ------------------------------------------------------------ --------------RQFVIKRKLRSILNDADL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------INRIDQIAENVSNIQFLASHYLHK---------------------------- ------------------------------------------------RSMQVIL----- -------------------------------------SEDAALIRREFDRPVRDLMFK-- ---------------------------SDFFAVKANTRNAERDADFMQWLADVNPPILLP DALHCDNALQHAMKMYKT------------------------------------------ ------------------------------------------------------------ -------------------------------------NYANNIKMR-------------- AKQMFRK--------------FCKAVLYSTGRIWPRIVLNKLINRAVDWFFYFTRYEPND RSPVRTIIDEFIWDILIDDEDVGRGFLSGSLDARNFYQFAK-YFIKMQLYVHHYNDTHP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ER-MVKSF-------------------------------------------- ----------KVIP--------LHNYHKRMVMIDTETMKKMRHMHFDKKI---------- --------------------------------------HNINP--------PKSDVWAPF RLEG-------------------------------------------------------- -----------LEKINQRFDFK--------------------------IM-S--DGVTAA ILMMKLNPHEFHIDLNLPSKINGVSTRP-------------------------------- ------------------------------------KDLPLK------------------ ------------------------------------------------------------ -----------------------------------------------------------E RFDHIPRGAIENINFDAKIGIDP-GAKT-MAACTK------------------------- ------------------------------------------------------------ --QHQNRDLTEECFSIESKKYRELAGTRKNEYNRRSITGRFDKREREAREASEIL----- ----------ITSNGPDYAEFVRHKLEFFNEGRRVYHHPY-------------------- ------------------------------------------------------------ ------------------------------VRE---LK-FDAHQEKLAAMYA-IA---KE II-----------------GRSANRWNK--------A--LISFGHWR-WTANSPIRGIRT ----------------------------------------PLKL----LRFCLQQL--GS -TVIVIDEHR-T--SKL--CN-FCA--QT---MI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NEDRNS-----------------LCVD------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C--------------RPIQRTLAPAAVWRIKAHKSYLKRNPGAPKIREYTR DPNQQLER-------------------------NNQNHSPMNWNRDYNGSRAILSKG--- -------------LDLIAGHP----------------------LPRNYLRTTQ------- -RVVQRRRFA >MDe-2 ----------------------------------------------------AQKAVVC- --AYKKKFRQVNEFNINPNQIIAEHRRHA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EQLTRLKRKASE HIFFRLTSLVREGTGHQILLEFQTPNRVNFRRDINSVRITERNARSEPNAEFVEGSRVYQ IHPEG----NIVAQSIEPI----ITEFEV------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NFANSFIGE-------------- CYGRVKR--------------LLKCFARIHLENMEDDQIKIEIRNTMRYLFNDINDITEP NRTLIRLYRQELRPICRGQVPRGWWNNKSTWYSRVPDLINGLYYLKAYNDGQRIG----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RD-CFKLF-------------------------------------------- ----------TVIP-------RFKSHFVHKTKIDTRLLCLTMNKFLPEGQK--------- --------------------------------------LDSQN--------IDYTVWNRV FDMT-------------------------------------------------------- ------PLERTHTDRKLVFNYS--------------------------IT-T--DAVSMS ATMIQGTDREIEAKRELRGRGAKLAERKRLADERKMEESTKATKRKAGKDADEPPAKR-- ------------------------------------RNAPVP------------------ ------------------------------------------------------------ -----------------------------------------------------------T RERDLLQKLKSGEVFGTVIQIDP-GVKN-TLGCVA------------------------- ------------------------------------------------------------ ---IDMQNGHERNLLITSKYYHHLLQTHLRKERKRPIIAHLHAMIRGVH--ASYANP--- ----------PTRKGGDIREYLDSVFRLFDMFTEVYQRRV-------------------- ------------------------------------------------------------ ------------------------------FSR---MR-FDAHICKQKAVDK-IS---KQ IA-----------------SLNPHQESA--------T--LIMFGNSQ-MSRKSPIKGYVK ---------------------------------------SPHKNYW--VKQFDELE--RV -EVYEVDEYR-T--TKT--CS-FCG--QI---LHVTRN---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------IGHRYV-----------------SCKD------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C----------------YPAGNASMVNEPKEVQTKSKQYWRRHHYRVNGIR TFSYSWEE-------------------------RMSHRKCRTTNRDINAPRNIGLKG--- -------------FATITGRE--------------------NLLPVALIRAND------- -ND------- >MDe-9 ----------------------------------------------DEWAFWEHQDVGN- --GQLRLRNEALHRLLYETEFEYPKQKEDEIF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TLVRGLAGMLQD EFFFPMMDKINDTVPLITKAIKLGSLHLHFCLFDLVKRGTIREIKEEFLGKFNTI----- ---------------------------KYFGPTRKTSHQCRYEMNKGFEYYMLAHDVHPP ELEYSTQVYAFAVQEYER------------------------------------------ ------------------------------------------------------------ -------------------------------------NFQTNVKTH-------------- AYNRIKRLFDYHSGVGKDKYNALKYLFDEDSDIEPNDYVLSLLRVYDEVLQPLTQITPEE KRRRENADEPVIPRGWLATLSDKKKWYKHVYEFINLLQWFYHHNIEEP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------DF-QKKLF-------------------------------------------- ----------IAIP--------QSKIQNHLITIDTSAIVDMTNSFLEPGKKTNKTTLEGG LDA-----------------------------------PGFKD-----------SFWRTY FKID-------------------------------------------------------- ----------QLNNGRQYFDFS--------------------------LQ-T--NGVAVH LKMKKRKLWKPIMKFRSDALPPTSSNIWDTH----------------------------- ------------------------------------EFARMT------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---DRMRMRWANKRYRYLIGFDP-GYKL-PAAIVR------------------------- ------------------------------------------------------------ ---QHCATKNEENFTMHWKEFRNRCGDPRRKRKLRKLTGWYEDLARSIRENRELYPEQ-- ----------PSPKSPDYDTYIDYQMRSFNIGCAVYQKES-------------------- ------------------------------------------------------------ ------------------------------ISR---LR-FDKYICTQRTLHR-IA---KE IT-------------KNDKVPKNPEDKN--------C--IIGIGDFS-FKPNSKIRGSVR ---------------------------------------CPMRPL---YEILKLYA---- -DVVEIDEFR-T--SKT--CS-ICG--TQ---MEKTGG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RKDRFF-----------------VCHN-SDPVG SILPRAPEWTSKLHHSKITQIMRRLPEHERYYVH-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EVT----------------------------------RQQNAVPKEWTHRNWD FLNWNYDL-------------------------DQVQHPTIVWNRDINAPRNMIHIL--- -------------KSMLNGIE----------------------KHPIFNRGDN------- -NNPD----- >PSo-4 ------------------------------------------------------------ --EAGWHFQISLQSSPPRTSELAPSAMERAACRPPGRLRDWKRRYACSTVRCKLGRVCPH PELINEIQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ICARLIL----- -------------------------------------KSTTEAWAL-------------- ---------------------------ANFHVLRQCEERGDIP--------DLTSSTFSP GAVESSAGAFAEDDVRLGDLYDSAVAFLGARPSTYTYEPDDVTKIDVLHGEAGGLMSV-- ------------------------------------------------------------ -------------------------------------NATNMVVTQ-------------- FRKHFTL--------------FVRLWYGISAKETRKVVR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACYSSDASERREVLEMKAWLGSAAWGEDGELEQVFPRKTVIK-----KHVGYF VRKLYEIMVFVEQNQIEQRR---------------------------------------- --------QR-AQSMF-------------------------------------------- ----------SLLP-------LSQSFALYNIKIDPSTLAHLCSRIYKRTGENVLGVELTP NNRIPTR-------------------------------PYFTQ--------RGSELMRRA FNIT---------------------------------------------QFETRRTKIGK ARFNGLSVDEKARHAARFFGDS--------------------------IR-S--DGYAAS VLMVQLTRLARSVGRREENEEDEELGDADEFDDDPDSESLVTETNGEEITEDEPELEPEE DTTHE-------------------------------QDPSIA------------------ ------------------------------------------------------------ ------------------------------------------------------SEVSDS APYPAPEPALRGIRARGFVGVDP-GKKA-PCTAAI------------------------- ----------IGKLCSKKKKPPPPPPPSPKPPRWHRNKRCPVEDRVSSTGPPRTPVRRRR EPKLPKVQHEQRILQIKAGEYQHMSGSKKFNKWHEKLRLRFPEYQIAI---SSLPCL--- ----------KTADARVFLVRMEQVWLSLDYFLDFGIAHN-------------------- ------------------------------------------------------------ ------------------------------FRK---WR-FFSHVKHRIAVDD-VA---KW LI--------------------PEAGAH--------V--CVGLGNWS-QSDNIKGGPK-- ---------------------------------------PPLRPL---EKAMRKRA---- -TVVKVHEFR-T--SKL--CS-ACY--QP---MKMAVFLDPDDPGPDELDADERPL---- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------YYDRSV--------------L--RCAN-KN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------KKNFLNRDVNAAVNMQTLL--- -------------MARLQGLP----------------------RPAEFVRQ--------- ---------- >PUl-1 -----------------------------GRKRKKDDYPEEWDVVDETQDPDAIPPLFE- --IVAETQDSDAEVDVVTNALSQLPPPSQKSLAPPTYRIKETTKEINSSVICKLTRICKF PLLVGEIK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KVCVAMK----- -------------------------------------QVQLEGWHL-------------- ---------------------------ANLHVLRCLKEGDEVPKIEQMFFYRCCTATLGN IEKRDRG----STESKYPAFHKTCLRYWAGRERESTYEPEFIQTAGDMVNEMAKLMEI-- ------------------------------------------------------------ -------------------------------------NALNMIALH-------------- FRQRLHQ--------------YIQFRYAKKGDTKLKYRE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TRRLVDSCYRVKSEP- -----EKDDEGNPTGKTAKVWTEWDDTDDPVEQELREWLGIAPWQWQIR-----ANPAHF LHKLYDMLVWMEKFVDKHPK---------------------------------------- --------TK-GARVY-------------------------------------------- ----------SLLP-------VATTFQAAYVKLNASTLHGLLARLIDLPEVEDFLKKELN IVPTRKRTGSQLPFDK----------------------KTFQK--------NRSEVIRKV FDVE-------------------------------------------------------- ----------QFETLDRKFADE--------------------------IK-T--NGYGAS ITMIRPVTTVSVALVEKKASKKKRMKNDGTAELVSKEKTARK------------------ ------------------------------------KKVKTP------------------ ------------------------------------------------------------ -----------------------------------------------------EEIAEED TFAKELFKLGPDYSPNVLIGIDP-GMRS-LATAVS------------------------- -----------------------------------------VGRLQRRRRRQKSRRGLHR RHRTRRARRKERVIEISTPKYRHLARMNDFRFYNENLKMREPWYAGVI---RAMPSF--- ----------KTSSYDLYFQRLQFFWKHLRFLLVFSAEQA-------------------- ------------------------------------------------------------ ------------------------------FLR---WR-FTQDRAKMKALDT-LA---KR IV--------------------PKANKQ--------V--CIAYGDWS-RR--DGIKGHAS ---------------------------------------GPVKGF---VEALKRRA---- -TVIPMDEYR-T--SIT--CS-CCH--QR---LKQARLFTKMKRKEDEVDIRQKERPSKK EVKEIVEMAKFKNPKLADKKVVL------------------------------------- ------------------------------------------------------------ ---------------------------KCTRNV--------------L--RCTN-SK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------KANFWNRDVNAARNMLELL--- -------------KSGLKEKH-------------------GARRLRAFRRGQ-------- ---------- >PUl-4 ------------------------------------------------------------ --SAKKPKKVSAKTSQQQVRVGKEPAARKKSS-GTVLENAFKKGKQFCSITCRLETVCPD PDLGQQIR---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------DCVRRMK----- -------------------------------------QIQMESWHL-------------- ---------------------------VNLHTLRCLEEGIQLPLYDETFFDQCCSGVSST SRSHNTA-------NKNPALWETIKIYRAERSRTNLKEVENQVGLPKMKYELRQQMVA-- ------------------------------------------------------------ -------------------------------------NAGVMLREH-------------- FRRRLCA--------------YVKVVYPNAKEK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DVLHG CYNSEPTKLEEVQEMRALLTPDGVSWCEEW-IPWPNRITDDSKIEFYIRLLWKFQRVIED HIEANPGRSTKGVRAF-------------------------------------------- ----------SLFP-------VATSYTASHIKINATTLAGLCSRVKKKDPETGGDCSITK WWGVDHIKIDH---------------------------NAFAA--------EKWTVMRKA FDID-------------------------------------------AFETLRPDTDVSQ ADFRHMTVEEKYAHASHLFANQ--------------------------VT-T--DGYGAS VLLFRTKNELDEAEKQ-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QSERLVPEGYRPEVVIGLDP-GMRS-VCTAVR------------------------- --------------------------------ERFVPGQIKRVRRRSVRKKRRRKRSWIR RYDGPKRKNGRDIVEVHAKEYRHLAGFRKRRTWEEVLKNSNPEYGTAI---RGMPSF--- ----------KTSRYKVYLERLHYFWKHAGFLLEICWRKP-------------------- ------------------------------------------------------------ ------------------------------FLK---WK-FFNKRSSRIAVDA-LA---AR IV--------------------PDPSVQ--------T--CIAYGNWS-RR--DGIKGHAS ---------------------------------------SPVKSL---QQALAKRA---- -KVVILDEFK-T--SKL--CS-TCH--RE---LSPVSYLVNPDLDKRRKRAGKIISRYHS EERKL------------------------------------------------------- ------------------------------------------------------------ ---------------------------VECHAV--------------L--RCDQ-KK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------EASYWNRDVNAAINIVNLL--- -------------KYEIEHGG----------------------RMAAFARVQD------- -RRD------ >PCa-2 ------------------------------------------------------------ --RIAENKTT----DYVSVKTTLNSFCKRGGRFLPGRALPWE------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EVLADMN----- -------------------------------------KGVLEAYLL-------------- ---------------------------ANVHVLRLLKEGKEIPVLDHNFFRSCLSAVMKL IVNHKIKGELGESLKVYNASRCVRSLQANGGYINQGWCHNAADQMAT------------- ------------------------------------------------------------ -------------------------------------MTKNALSMN-------------- FYRRFHK--------------FLKRTYMIDGRKAYTLLQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------GILSHEDYVPQGTRFDSIVQEWREKIPRKGNGRLANDA-----HRLIPL TYTFLKDIEERNLYGDQVLDEGEQ------------------------------------ --------YH-ELRVF-------------------------------------------- ----------SILP-------TKRGFECSHMKMCQLGLWGLLKRAGYTIPNRG------- --------------------------------------SGWEE--------VRDQYWRML FNIK-------------------------------------------------------- ----------KFETVNRKFAGE--------------------------IV-T--DGKAVS IIMRKPKRE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---AEPTKKYSEDDFDVFWGLDP-GRRD-MFVATN------------------------- ------------------------------------------------------------ --------QWDETVSCSSKEFYEEARYTKAKQKISGWRDRNPQVLEAI---RNMPTK--- ----------KTASLEKLKVYIAFMTQRMDFLLGFSQLKP-------------------- ------------------------------------------------------------ ------------------------------FRR---LR-LRSFIFMKKKMRK-LC---EQ LV---------------------PRGNR--------V--VVGFGDWS-NQDVGGIIKKCP A--------------------------------------GPVKVF---ERELARHC---- -TVIPIAEYR-T--SKV--HF-DCQ--HE---LKNQYSQRLCRDGEIRT----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RKVYSV--------------L--HCLN-NG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------RGMTVNRDVNASRNMLRLL--- -------------QCKLRDED----------------------RPVAYTRQWT------- -KKNSAIECL >PSo-2 ------------------------------------------------------------ --RKADAKTV----DIVARKVTLKSFCTPEAR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ALHWN---------------------------- ------------------------------------------------DVIMTMNHAAAE GWLLANFVVMHTIENPTGGGVLPPMDDKFFR------RCMATVSKKSRPKKTFKAVFQKS KERKVQPDLALEEWKWVDF----ERAADEYLKHRGGARPLDCKYICLGWFEQAATQMAK- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NTETSTWKN-------------- LARRLRQ--------------YVRVKYPEHRADAFLITS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------WVLDEACNRRHCKS- -----CRTKKRQKKPVPAECQSCDAVNGIVGALREDIPRNQNQKVDWKS-----TDVLRL FHKYLKAVEEFNETNKDNPK---------------------------------------- --------IR-QERVY-------------------------------------------- ----------SIIP-------TKQGFRSSYFSMTSTGLWDLLRRSRDRLDLDTIVYTEGG GSISLGDSIKK---------------------------ENWSG--------VADIWWRKL FRVA-------------------------------------------------------- ---------DLEKGTRLVFHGQ--------------------------IC-T--DGIGAS VLLHKPKRE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PKAEPPLRKIENYDEIKGADP-GFTD-MFVACT------------------------- ------------------------------------------------------------ -YNVRSQTFSDDFLSYPAKKFYSDSGYSSSNRKIRRKLGHNAEIKKVF---KDMPTK--- ----------KTASLTKLMEYLDYTVPKMERLFSFFMTKT-------------------- ------------------------------------------------------------ ------------------------------FRD---MR-FRRQMLAEKNLRA-IC---RE LA--------------------GEPGTR--------T--LIAFGNWE-LNNSSGIIKKKT P--------------------------------------GPVMKL---RRMLTDYR--GV -DVMIVDEYL-T--SKM--HH-GCYSLAP---MENQQVKHRCRDKVVRT----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VGVHKV--------------Y--HCLK-RNGG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GA-TVERDVNASKNMVEVA--- -------------LTQMREGE--------------------GVRPERLQRPS-------- ---------- >SPu-3 --------------------------------------VAAFSPLTHPDMGCPTCNGTD- --HHRASSKLCSFYKPRKKNEVRTTLKRKRDTDLPNDEIFILSTVVKSGQRSPLQVVIA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HAARTLTCIAAE ATRLFNMFVLDLL---------------------ERKQQIPECSYNKFLHQPFQIIALAK ASSPQ----LQTIHRTLYR----QTSRYDVTYLSQLISNMAKDYET-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NCMNHVSTN-------------- IRKWAFK--------------WYRMKMQKTYPDLKRDKIRILFNKEDDLNEHSLYLKACL MTYDVDITKEVSFDHWWTYFPLMWKFQRYFA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KH-GERNF-------------------------------------------- ----------SMVP--------ITTYGIRHIRLDTNALYKLCLRVDLFTRKDVPA----- --------------------------------------AEFRT--------NALVYWKTL FPD--------------------------------------------------------- ----------IAETSNKSFAYG--------------------------VS-T--DGVACS YYYQKRYVR--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RRQSHNYYG FDDDGKYGAMNLEDGVSIVGVDP-GRID-IFTAVD------------------------- ------------------------------------------------------------ --------GNENVVRMSRKEFYSLTGMVASQKTRNRWLKNNPAVQSIV---TQCPTP--- ----------RTPDIENFRQHCQYVQQHLLTLVDFYGARR-------------------- ------------------------------------------------------------ ------------------------------FTR---QK-LHTYIGKQKVWAT-IV---RR IT---------------------KNDRR--------T--VVALGDAK-FRHNSKGGPS-- ---------------------------------------TPLARM---AKELKRRH---- -RVRMIDEFR-T--SIT--CS-HCD--GE---LPKSTRHWQVKVRWAVMNS--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VSQKXS----------XICVFCQVCND-L---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------------LTHWNRDVNAARNIRNIF--- -------------LHMNENNG-------------------E--RPCCFARTVP------- -QFNPGWNL- >ALa-1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SGKYKGLASVYFVAAKKIRPINVSINNTVLNNIHKGI-- --------------------------------------GFVEI--------VDEDLWQYY FN---------------------------------------------------------- -------TKLVTRGQSHSVEQF--------------------------MV-I--DGMSAS LIVSRPDKATVEAIKYKE------------------------------------------ ------------------------------------RDIILQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MHETAQRIVAIDP-RRSPVFTAVVK------------------------- ------------------------------------------------------LQMNHS RNTILTISSMMLYNGLVGSSIMNAATHTGTNMIRKVWCNSSAVITSFN---AAKPSN--- ----------TTGSLKLYKVYARYILHDLDDGLKFYSATS-------------------- ------------------------------------------------------------ ------------------------------FKR---LR-WKTYIQLYMEMQT-SV---RQ EE---------------------AIGNE--------P----------------------- ---------------------------------------VPTRKM---RQKIGSRA---- -KTIDFDEYG-T--SIS--SC-CCH--TQ---MEGGSHKIKQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MVSDFM-----------------VCGV-VLYTS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------SRKVWDRNTSAAINVLKIF--- -------------LRK-------------------------------------------- ---------- >MCi-1 ------------------------------------------------------------ --HKTTMHTYRLLKYIILHRINNHHFDAMYYL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------NHRFIH---------------------------- ------------------------------------------------EVYMKLI----- ----------------------------------------------TKARERAPRTQDTI ERRAIIDQYLPAYLRLVGINDPRELPLMXNSQQSAMYEAAKIST---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AYLNNVRNN-------------- FGKRLRQ--------------VINVLLNVKARQRALRQLLRGQAMDQRAINQAIRRQITN PARRF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KIALSN-----RTTIEA LH-------ARFDDGPEGFYTTAIDQLAPFLETYPNNMQFAQDNIYYDCKANPHLHFKAF FRLAELLHQR-QVRSF-------------------------------------------- ----------CVFP-------LRQSLIPGYVIVDTKILMTQIFQRSVRPGE--------- ----------------------------------------PLR--------HRHE-WGQF IDFRMPIFRAQA------------------------------------------------ ---------------GREFGNM--------------------------IE-T--DGVGVS VLKREQHDLQFQQPRQQGAPQQ-------------------------------------- ------------------------------------QEFPYI------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TDPEVQIPPNCVVIDP-GRRD-MLYCME------------------------- ------------------------------------------------------------ ---ENSTPQAPRMFRFTKPMQDKIRKNK-RYRRILQQMKPR-RIADME---RELTNS--- ----------NTLNLQVYQQYLQNFGRVYEALLLYYSITRGASQTGQFPI---------- ------------------------------------------------------------ ------------------------------HRK---LR-LSAVINKNRCDQF-LI---RF LN--------------------TKFPNT--------T--TYIMGNWS-APHTRFQE---- ----------------------------------------PIRGLG--FRRLLQKH--GK -QVFLVDEFK-T--SKV--CP-QCQ--QP---TLETFKQGINPRPYRRATQLY------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TTVHGL--------------L--RCTN-RN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------HAAHGLPQRFPFRYFNRDTAACLNFIRCL--- -------------QAVRQGLP----------------------RPLDLQRRPL------- -QDNDDDDEE >PBl-2 ------------------------------------------------------------ --HPLLSHTFTFLKYIFLHKLEDEPNFPLENF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VNEEFFK---------------------------- ------------------------------------------------KVFLSLL----- ---------------------------------------------KNYKPTKQKASAKSI AYKDLIFSYRDQYFWCCSY----EPIDMKYAHQIASYETAKILT---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AYLNGIKLQ-------------- FGNKIRM--------------FLNLLLKKNERIKAMESGMKNNGENKEDIATAV-KTIID SINKI------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KQVISS-----RNIEHI PG--------------EFISSATLDMIRNLFDSYPPDYQYSKGPIYYDSKANPLKHMKAY YRLSIMCEVL-QDKTF-------------------------------------------- ----------SCFP-------LQRGLIPCYMTIDTRILNTLILNYS-------------- --------------------------------------VISHL--------NKEVVWGSV MDINSKAIRPQGE----------------------------------------------- -------------AKDVKFRGM--------------------------IY-T--DGIDVS VLKQNSETKNKGVGGK-------------------------------------------- ------------------------------------KSISLV------------------ ------------------------------------------------------------ --------------------------------------------------------ENEF RYVEALEEEELQAGIGKCVFDDP-GHRN-LLYLMH------------------------- ------------------------------------------------------------ ---KGMTSKRKSTYRYTRNQKYVGTKAK-KYRKLRNDMKLGHIIAAEL--FLSQHNS--- ----------STTSKEKFINYLQEKAKATPAMKAYYANEDNPAEEDQRISGLLP------ ------------------------------------------------------------ ------------------------------FRK---MK-LSNFINQLQADKR-LA---KN IR--------------------KKFGND--------A--VLILGNWS-AGQSKYHE---- ----------------------------------------PIRGIG--MRRILAKK--DF -QVYLIDEFK-T--SSL--CP-ACQ--NG---ELETFKKVQNPRPFQRRKYPT------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VDWHDL--------------L--RCKN-QQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- -----------------------LKPVTESTEDNTQSSLYRLWNRDMAATLNFRHIL--- -------------FDLRKNRR----------------------RPERFCRLSA------- -RSFTTLKRK >PBl-1 ------------------------------------------------------------ --HTIVTHTFALSKHIFLAELALDPFFDLNGQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------INQPFFV---------------------------- ------------------------------------------------EVFLSLI----- ----------------------------------------------DRNTDSSRITEITR LNCELISRHINTYIHNSSY----TRISLLNAHQIAMYEATKIHT---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AYIVNIKLR-------------- FGQHLRR--------------VINILLDIKNRQRELTQQLRSQRATEERIKRMLTEHIFE PARMF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KEGVST-----RRLEDV FI--------------EEGYRTAFMEISPILTAYPKRYKFQKDSIYYDSKASPHNHFLAF FRMAQLLEHL-GRRSF-------------------------------------------- ----------NCFP-------LRRSWSPGYMQIDTRILDTIQQLLRRTW----------- ---------------------------------------SEGA--------DKLELWGIV VDLDEKAFRDQQNG---------------------------------------------- ---------------VMKFRGT--------------------------IQ-T--DGVGIS IIKQNKDTTQGPNPR--------------------------------------------- ------------------------------------RATTIN------------------ ------------------------------------------------------------ --------------------------------------------------------PENI PYIHDLSPEQHERIRGRCVLIDP-GRRD-LLYCMH------------------------- ------------------------------------------------------------ ---EESTVETPRCYRYTSNQQNIRLKRT-KFRRILQDLKAQAPNVIAAEHEISQTSG--- ----------RPNNTTDFAFHTSVKAANSSILSSFYTNTVSRTSQKPL------------ ------------------------------------------------------------ ------------------------------FRK---LR-LSSYINQRKANER-LA---KY IR--------------------AKFGQD--------C--VLVMGNWS-APHNRYHE---- ----------------------------------------PIKGVG--MRKLLRKH--GF -DVCLIDEYA-T--SRH--CP-RCY--QP---SLQTFKQVDNPRPYRRTQMPT------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VTRHGL--------------L--RCTN-LN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- -----------------------------LENTDGSEVMHRLWNRDVAAVLNFRHIL--- -------------NNLRYDGT----------------------IPVRFTRVIQ------- -IGRIRRQAE >ROr-2 ------------------------------------------------------------ --HATTTHAYSLSKFIFLCALQDDANFDIASY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------INKEFFS---------------------------- ------------------------------------------------EVWLSLV----- ------------------------------------------------RYRRGRVGEATA RRRTFIGQYIQRYLDYTTY----ERPELKYAQQSSSVEGLKIYT---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AYTNNIGAH-------------- FGNHFRR--------------AINTLLQIRQRKADLIRQRQEEGVDNEAISNEVYEQITL PARQF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KEILAS-----RIVDPS SIELPFQ---------DPIYNQALQRLTPILTSYPVRYTFEQNNIYYDAKANPCEHMMAF YQLARLFEAL-RLPIF-------------------------------------------- ----------NCFP-------LRRTWIPGYATIDSKILCQNIL--GRRW----------- ---------------------------------------TNGI--------NKMNLWAEI IDMNSAALKPQELG---------------------------------------------- ---------------VLRFRGT--------------------------IQ-T--DGVGVT VLKKRQDRKHRYIGL--------------------------------------------- ------------------------------------QSTFVE------------------ ------------------------------------------------------------ ----------------------------------------------------------PE PYITDLNAQQHGEITGRCVTIDP-EDET-FCTVYM------------------------- ------------------------------------------------------------ ----KTLLLMHHAHIDTPSLVKIRWKKTKKYRRICEAVKPQ-EVQNAE---DTLVNS--- ----------RSLDLQNFEEYLRNRALVTELLQRHYTETTTNHLTTHPL----------- ------------------------------------------------------------ ------------------------------HRK---LK-LSKYIRRQKASED-MV---AK LK--------------------SKFGND--------A--VFVMGNYS-APNTRYQE---- ----------------------------------------PVRGVG--FRRLLKKH--GF -LVYLIDEFR-T--SQC--CP-SCE--HR---SLTTFKRIPNPRPYQRRNNPE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VICHGL--------------L--RCTN-QN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- -------------------------KVTVQNISGAEELRERLWNRDLAACLNMIHIV--- -------------RNLRLNGE----------------------IPERFQRAGA------- -ERRRSEENE >ROr-1 ------------------------------------------------------------ --NLLVTHTFAFTKYIYLQELAANENFALNNF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VTKDFFV---------------------------- ------------------------------------------------EVFLSLV----- ---------------------------------------------LSKGGNSTRLKDTTK NYRRLISKYKEAYFEDAGY----TPPNLPYAQQIALYECTKIQT---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AYYNNIKAH-------------- FGNRLRS--------------LINKLFKKKEKAESLRGEMQANKSSSKAIKEAIRKKIYR PCNQV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KLAIAK-----KEMPEV ----------------GLLDDQSRTQLNDFLSSYPEDYTFQENSIYYDVMASPKNHFKAF FRLAELSEAE-QTKQF-------------------------------------------- ----------ACFP-------LRSTFIPCYMTLDSKIIHYHILK-SKKN----------- ---------------------------------------PKTG--------SKFETWGAV VDLNKKAFKHQGF----------------------------------------------- -------------QKSLRFQGT--------------------------LE-T--DGVGVS IIKQNTDTSRKSPKPN-------------------------------------------- ------------------------------------TEKKVD------------------ ------------------------------------------------------------ --------------------------------------------------------GNQT EHIEGLGQADLKSTEGKCVLIDP-GRRD-LMYCMK------------------------- ------------------------------------------------------------ ---ETSTVEEKQTLIFTKNN---RSKCSRHFRYLRKRTQPFVVQKAEA--ILSRSES--- ----------NSVNLKKFVQYIKTRASVKNTLYEYYGNETTKSKETYFPESEFDFRVDQK CNLYYGNLFIARIRGFFPQPENYSTDSSVKSQLYATYLQIMLQQKHISERLDDSEKSKVL GLAKEMYRRPQKSNYKKTISTALEKLQLLPFRK---LK-FSSKLFFDQNDQK-LV---RS LR--------------------AKFGQD--------A--VLVFGDWS-APNVKYQE---- ----------------------------------------PTRSKG--LIRMLKKN--GF -VVYLINEYK-T--SSH--CP-TCE--NE----LEKFKTVPNPRPYQRKKKPD------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VLCNGL--------------LSTRCKS-LS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ------------------------------LKQQTTGIKRRLWNRDQAAVLNFLKIL--- -------------NSLRKTGE----------------------RPSLFTRKYP------- -LD------- >SPu-1 ------------------------------------------------------------ --HQLADHASHALKFYILSAPTFPTVNEDTIE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AILYLLN----- -----------------------------------------------KGEAWHPRKEAKK AWRDCLLPYVQRYCQIVGF----VHPNLRGEQQSVNYLTASMMT---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NLKVNVQEH-------------- FMQMLLR--------------YINLRLDVKGQKQRLPPKSDARKAFFARLRYL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------KSVFLFDIVPESLDDLTAEESELLEEXWSLNLPFPD---------------RPA ARIFGLYEQH-GFRRF-------------------------------------------- ----------SAIP-------LRRSLIQSHVRIDTVILYPHILCITRRE----------- ---------------------------------------AEAV--------EKVDLWLRV CNLRTKAFRSRR------------------------------------------------ ---------------GMQFEGS--------------------------IT-T--DGTSVS VYLKHPEADKYGKRGARKSA---------------------------------------- ------------------------------------KTLEAE------------------ ------------------------------------------------------------ -----------------------------------------------------------V KALYVENNLPACRAAENVVVIDP-NKRD-ILYCQD------------------------- ------------------------------------------------------------ --------SNGTTFRYTANQRAMETGSR-RFAKERQQMKKEAGIDLIE---SRIPSH--- ----------KTMNLMDFTRYLLVRRADWDRRKEFYSHPA-------------------- ------------------------------------------------------------ ------------------------------HTR---WK-WHAFINRQKSESD-LI---SN MR--------------------NKYGEN--------F--TIVMGDWS-DAGRTARFQT-- ----------------------------------------SSKTKG--WRTLFKRN--RI -NCFLLDEYK-T--SSV--CP-RCS--SSDDFLEKGFKTRPHSRPWRRREGKI------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EKVHGL--------------L--GCTN-PN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------LQQAWTMRYWNRDTLSTCNMLMIV--- -------------QSMLDGHG----------------------RPEVFSRSVP------- -AVA------ >PGv-1 --------------MKKKKKGEFQEFRNNEKSAYKTFKIPIKSILYNYDTTQPVINNLVF EINDLMIHAYQFIRLYVLSCYTNKQTLPI------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------IDDIFIL---------------------------- ------------------------------------------------YCIKTLG----- -----------------------------------------------TRDNRGKKCKDTA LLDTLEKFYLEEYQPLLNH----EKTNLKNTTFLLPYLATQIHT---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SLSNNAQEH-------------- FIQHFLR--------------FINTTTTAITEDKSILFKLKHQLMSLDNETN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EMFNEWKITHLHNI---FPQNI---KKSIHYDVKVRPFEYLKGM LYMNEVLEKE-EHKLF-------------------------------------------- ----------QPLP-------LRTNIIPKHIILDTASLVSLFCPETDKDGN--------- --------------------------------------KNKKGNLLSNIKDNQYDIWNSF LNLNHKIFRNQH------------------------------------------------ ----------------YQFHHQ--------------------------IQ-T--DGISCC LLFIRKDLKDKKWGS--------------------------------------------- ------------------------------------RVPSIP------------------ ------------------------------------------------------------ -------------------------------------------------------EQDFY NIEDLSKEQLDTLKDRNIVGCDP-GKRS-LVYMMD------------------------- ------------------------------------------------------------ --------KNGNKLQYTAPQRKRESKAKTNQRILLEEKKRHKIIEKET--ELSLQNS--- ----------KSVDYIKFKTYLVEKHKLNKETTEFYKKET-------------------- ------------------------------------------------------------ ------------------------------WRK---MN-FRQYSYGKKSIDT-FL---NK IQ--------------------ETFGSN--------I--LIGYGNWS-RSTQMKHFM--- ----------------------------------------PTMNKG--LRKQIHKK---Y -DTITINECN-T--SKK--CC-DCN--KD----LEYYKDKENKKVFR------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------L--------------L--VCSNCVS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- -----------------------------------ENKKIVFRTRDANSSINIMKLT--- -------------SCWIDSQT----------------------RPTAFHSHISSFTCSTI KEEQEKVRPS >CRe-1 ------------------------------------------------------------ --AGLLSEKI----EADGVAVTREESLAAVDF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------LVAALTRLRFE ALCLLGLVAVRMC---------------------EDARREGQGLQ--------------- ---------------------------PHCATCRRLRKTELVEDDMYAAICAVSVCDLTE QGRKRGRPSKRDQHPEDDLFRHVCEEHFPRDEEAAGARVNRSGLTPFLPPLSKGVFT--- ------------------------------------------------------------ -------------------------------------NVKNHYAAN-------------- FAAWLAR--------------SFRCRIDDELRELRTPAT--------------------- ------------------------------------------------------------ -------------------------------------------------KKLDKLAWSMA HAVLYDGELEQPRWWVGWAQGAAGAAAAAAAQGAGPAGGAAAAQAWTALVDYVNAQRAS- -----KRAAELLLREVKGAQATYKKASTRHMEWAAEILAGLEARRDQLG-----AQVQQL TQAQPLTREDTQRLASLRRE---------------------------------------- --------LH-RARPF-------------------------------------------- ----------TLTP--------SPSFAPIYVPLDNTSMARLPGLLPTLARRHGEVFAGAG AGAVAPSSFVQ---------------A----AFGGGGMQSSAT--------LNAVGW-GL FQLG-------------------------------------------------------- ----------GVTSRNAPFANY--------------------------IT-T--DGVACS VA---------------------------------------------------------- ------------------------------------REAHNK------------------ ------------------------------------------------------------ --------------------------------------------------PLANLKPATA PADAEELCTLEEMKATQIIGVDPCGGGNWFMAARS------------------------- ------------------------------------------------------------ -----PRRQKRGRFHMSMGHWRHMSGLERLQPNRPQLAPALQAYV------GGIPTA--- ----------ATASAARFEERLRYLFEAGPRGAVHVLWHYHFSA---------------- ------------------------------------------------------------ ------------------------------FRR---KR-WAAFIQRDRALHR-VA---KQ LT-------------------GGRPKEE--------V--VVGWGSWA-FQGGKGGSPISV RG-----------------------------------GRAPTGRL---IKLLRERY--AK -HVFIIDEYK-T--SKT--CY-NCG--CQ---EMAIKRLGGLK----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EGQRPW--------------SVKVCND------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------------LTTWNRDVSAANVIRVLL--- -------------LLKLMGFE----------------------RPTKLQRPPW------- -PPAAAGPG- >CRe-2 ------------------------------------------------------------ --VQKNSTRKVSLRSVCKDEATLAAIRFKVDFVAXPLRY--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------RLLDFLRHFVVC RTDPAFHCAVCDT---------------------RWREQCGLAARRQGLRERADVSPQQH VFHRR----VPTIDI------------NLLQESAALITTSTHRRQRQSLLSHFYDAHFAP LLSEDTGGPAIDITAHHQLVHHLLQDVLT------------------------------- ------------------------------------------------------------ -------------------------------------NLEQHYRAN-------------- FPKWVRK--------------YCRAKLEVNDDEVPLGGLAGMALGQPQAGNEGGAETDEE DEEDQVHVTAKARKALAGLMTAALMGWRQLPLTEADLGGLAVPDALLARANATVAPLVAA WTARGIWPIQRGSRGLLQREPLCLVSAAADLLCGLQPIRRWLATVYERLKTANPPAPPG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EVRSANFAMK-RAQTY-------------------------------------------- ----------ALII--------EASSMPLHIPLTNTIIQELLVNHKQLAAAEYAAAGAEL LGSNATAVWQAATAAAKHAGGW-KAFA-------NVQQAAGAP--------AHHDAWRDC GF---------------------------------------------------------- ----NFDWLKRLERGGGTFAYF--------------------------MR-T--DGAAAC VTLTDAAGSSSYLDGPGRAPGNNPVPGVVAAGQAL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AQYTPDALKAMRVVAVDP-GCVNYLVACVD------------------------- ------------------------------------------------------------ -YLADFREQRKCYARVSGAGYRKRTGQSERQRWQEARLQEQPALQRWQ---AGIPSA--- ----------RVAYAADHTRRIQYLYGIGLWQLLRHYRQWG------------------- ------------------------------------------------------------ ------------------------------QRR---WR-LTVYIRSQKVLEQ-TA---QQ LA-------------------GGRPKEE--------V--IVGWGNAN-TGHGGCVSRS-- -------------------------------------GRGPNRAL---LRLLVDKY--AH -LVVYVDEYY-T--SQV--CA-KCG--RR---LLGNGQRCLEVVIPFGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SRARDV--------------Q--VCQH------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GT-VWGRDANSATNMRHAL--- -------------MEMLLGKP----------------------RPAALRPAGA------- -HVRSRGGGQ >CRe-4 ------------------------------------------------------------ --PTAAAADV----QRLASQHRDSAVLLQKAL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QVLVWVMTAVRQ EAFDLLLLVVALC---------------------AEDTRLQAAGQPPNPERFRGQSSIAE GFRRQ----RQRACGSDQP----HHVTNDAAQRALRGFPDLNQRVMEDCITAVTTSEHHQ EVQHSDQRAGRDPHSHNLAQYVYGHVFQVHRSEDRVGPPRSVTGLTSVVHQLAR------ ------------------------------------------------------------ -------------------------------------QMETNVGVH-------------- LATNLFR--------------WLKTRCRVQLHRTLHPEAAAAAPDAGAGGGAGVELPRQQ QTIVLALAAAIARDEPLCAYPDAAAALQSQPDVLQELELWVQQEQDRWRPRGLLVPGCSF KRHSLPHGERYLAWAAEVLHEIEQHRSQLRARGVPKAKV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AR-HFPVF-------------------------------------------- ----------GLLP--------EPSYQQVHIGLGQEAVKELLVHRDHFASEHHLIPPAAV PT------------------GKFRNIP----ACFKEWVADHGL--------DPGDVWAAA GL---------------------------------------------------------- -----RLGISQHEHRGSKFDGF--------------------------VT-T--DAFDMC LTMRRRYHSSWDEAKEAG------------------------------------------ ------------------------------------KQVRVS------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------EEELLRLSLRGVDP-GCSPIYWTCAM------------------------- -------------------RWPWLPAWVVALLGVDLVLRLPEVRNGSCPVRWPDDLTKDP LALMVAQSAEHSKTHCSGAEHRTNCGYAQHQRWQQWRVKADPALCAWQ---SSLPTA--- ----------RTVDVQNVLGRLDYKYVVRELGFVDLLARYAAPA---------------- ------------------------------------------------------------ ------------------------------WRQ---KR-LQVYCQKQRVLCR-EA---VR LM----------------GGEPEVTQQN--------G--VVGWGGGS-AGFHGTVSRADQ ---------------------------------------PPRKGF---VRLLRERF--AR -HVIMINEYR-T--SMV--CA-NCG--RL---SLRRKEPPQGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ADFRVL-----------------VCND------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------HT-TWDRDENAALNMRLLL--- -------------VLQLLGRD----------------------RPAVFCRPEG------- -GVD------ >CVu-1 ------------------------------------------------------------ --AAETSAKL----QRFTIVTGLLSVLQNRAL--RHPIN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EAVRDTTFVKYE TLTLLGLYVAHYC---------------------KEVRRRAAEGL--------------- --------------------------------EALPAMPYLGATFISHCIRLVT------ ---HSDEAPRWNQLPPDELLLSVYHHLYLPSRSNNLRRVNRDRRSEQLHYLAIQLAV--- ------------------------------------------------------------ -------------------------------------NVQLHVRLN-------------- FQRFLRR--------------WCSMRLYQDFGE-HQPSPRG------------------- ------------------------------------------------------------ -------------------------------------------------KVLDRMVKSIC AEQCLNTDL--------------------------PEGLSAAQRAWVQAL--VTSQRAAH TTLLPADARELRRQGQKWQQRQRQQKQKQREEREAAVKQQAEELRNNPGIPAPPPRAQEL RRKRKKKKKKRQQQARVEAA---------------------------------------- -AAPTAWRQP-RVAPF-------------------------------------------- ----------SLMP--------VAAFTPCHITLNSDGLRVGAANALKGDTSRV------- ----------LSLQAMVNTLGK-KTKAAGGRALGEEHKQQMLL--------RDVELWDAH FDMW-------------------------------------------------------- ----------PLCTVNHKFALF--------------------------LT-T--DGTQAS VHMKRPARKPPAPPSF-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PMSLVGKQLLGLDP-GRRHFYTAVSD------------------------- ------------------------------------------------------------ ----SDSKEHRDVRRCSTGHYYERAGFTARQRWMERRLAA-AGLQGWQ---SRIPRH--- ----------ATADLAAQQQRVAYVTE----RLDELVMHYCSAP---------------- ------------------------------------------------------------ ------------------------------WRK---KK-WSVRVQKQRVLAN-EV---RR LT-------------------GGRPKEQ--------V--VVAFGDGT-GGPGGCIKGS-- --------------------------------------RMPPIKQ---FRQLLQRF--AT --VLVIDEFL-T--SQR--CP-RCE--AQ---YTSR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------VSY--------------AVPVCNH------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GT-HWDRDVAAAKNMLRIA--- -------------RAEAAGLP----------------------RPADLRRGG-------- ---------- >HAgv-1 ------------------------------------------------PVCKSCGGLDH- --QRRSSTKC----ANFLPQVRKRKLEPQQVN---------------------------- ------------------------------------------------------------ --------------------------------------------------LDLQVYVVKR GLQSALCPLLSDDDRNRLLYEIRRDVRDLSRVYIELGILFN-----YYMKRCDTLPDKPD VLNFFYAMKGKGPYAACY----KHLAGDQVYDGKLRS----------------------- ------------------------------------------------FVVQELA----- -------------------------------------KQYET------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LIHTNIETH-------------- AYSRLAR--------------YFGVKKNDHGLFLAYYKK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DFSQATEDMIRVCQI-----INVDSC KKNWWSTVPLWLKIQQDLFD---------------------------------------- --------RD-NVESF-------------------------------------------- ----------RLFP--------QPSYGLKHLTYTSRGWHELLRRVKPDSVPSHW------ --------------------------------------PNIQD--------HIKELWAPW LK---------------------------------------------------------- --------------STKNFGCC--------------------------LQ-T--DGVSVS LSMNRWIKKVTKNGIT-------------------------------------------- ------------------------------------KEVVIK------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KWKPSYDKLIAVDP-GSRV-PVAAFN------------------------- ------------------------------------------------------------ --SHGFYKRVTSKFVKSHSLDWKRERVRTKLTKSSETAEAKDRERVQT---TCNIVL--- ----------SSKNTSHVVEYTVFRLKWFDVRQKPYETHSK------------------- ------------------------------------------------------------ ------------------------------LTR---LM-FDKYINTAKLQEK-IV---KE VF-------------------DGGGVEK--------T--LVLYGAGS-KFMNAAQFS--- -------------------------------------GRKFKHDAL--LKKLRQKR--NI -HVEIVDESY-T--SQA--CS-TCN--QQ---TGEFSKIVMD------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------HKKRVG-----------------VCPN------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------AS-RFDRDQNAAKNILINF--- -------------MRSTVCRP----------------------RCSYTKRVS-------- ---------- >SFav-1 -----------------------------------------------PLSCKSCGGEGH- --TRRSSKSC----ANYLPPIRQRRNSGDVDH---------------------------- ------------------------------------------------------------ ------------------------------------------------YTQDFDVGVVKQ GLDGTICPLLREDVRQRLKVEIRSDVVELSKLYILLGVFVNHCWNAYPDDESNSVRTFQD MMNYVYAIRGKGPHAKKFEDMVRYHGNIRRYDGRLRS----------------------- ------------------------------------------------FIVQEVA----- -------------------------------------KTYWT------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VLKTNITTH-------------- AYSRLAR--------------YLGVKRNDPTLFAAYYHK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EFGDDDSISRVCRF-----INVSS- --DWHSTIPMWIEIQRDMY----------------------------------------- --------AR-GEQSF-------------------------------------------- ----------VIFP--------QPSHGLKHVTYTSKGWHELLRRVDPSNVKSNW------ --------------------------------------PSITD--------HKKELWAPY LDTC-------------------------------------------------------- ------------VVDMKKFGCC--------------------------IQ-T--DGVAVS ISMNRPKRTSVRRKAALP------------------------------------------ ------------------------------------KSYTID------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AFFEDRIVAVDP-GSRV-PVAACD------------------------- ------------------------------------------------------------ --SRTGFKRITKRWVRSHTLEWKRDRYRSRKLRRVELNEAADRQRVEL---NRGVQI--- ----------TCRNGEQVKLYTDFRLKWFDARQLPFERTRK------------------- ------------------------------------------------------------ ------------------------------LTR---LS-FNKYMMTARMNER-IV---RE TF------------------LSDTPSDR--------V--LVLYGVGV-NFVNVACYS--- -------------------------------------GRKFKHTDL--LRRLRAKR--NI -RVQLVDESY-T--SKA--CS-ECN--EL---RNGTYTRLRMN----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------HRLRRG-----------------VCPD------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------NA-DVERDYNAAKNILVNY--- -------------QRSAVCRP----------------------SPSCDSGVAT------- -DTDPHSIRS >SWv-1 ------------------------------------------------------------ --STVYTSVKCYLSSIIKSESSRSNVTSTKERFEERC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KSVSKMMVKGSL FLRLVVDECLRRY---------------------NHLEDEIDKWPDMTKDNFYVQLLRKG LDKKK----LKEGSTHPVV----EDVWNSPIVQETFLSQQGEGNNPIKRHLMDFNTITYA AKQLKT------------------------------------------------------ ------------------------------------------------------------ -------------------------------------CFETNLRTH-------------- FRTRQQR--------------AISGWLAENGFDKKYTKL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------VQHWI- -----IGCTYKSDWVDSGDLERVKEGTKNFVTLHRKHLCVISDKKNGTI-----SYSPEE KYPIPSILNYYKFLQTEYPQ---------------------------------------- --------NK-KIQKM-------------------------------------------- ----------IVVP--------KHKLKIHYCTFDQTTIQGICKDLGVWKDMEERHK---- --------------------------------------QSEDI--------LYKQGWYLL FDVK-------------------------------------------------------- --------KIKKLRPNWNFHS---------------------------IQ-T--DGEGVS VLFSREV----------------------------------------------------- ------------------------------------EEVETV------------------ ------------------------------------------------------------ ---------------------------------------------------SKKSKKNKK PRGDEDRRNYPPTNAKYVVGVDP-GRTN-VVSCSV------------------------- ------------------------------------------------------------ --FDTRQKRVVRKHRMTAKQYYQESWMTDRRKANETYKKNNKEYKEAL---EEITRYDNG EEIINDGNGDTSTPTKKFEAYLKVVNEHYRLLWNEKGKKK-------------------- ------------------------------------------------------------ ------------------------------YRK---NA-MKVYSRKQKCISN-FI---DE LI--------------------PKRDKI--------EDYHIAFGDAK-FACTGRGEQYA- ---------------------------------------SPARIF---AKKIKERVGGDK -RFTFVDEKY-T--SKV--CH-RCN--QP---LNMLEKDCFSPNKKRKPPTIVTTTTTTT TEEDEENGKWKKATPL-------------------------------------------- ------------------------------------------------------------ ---------------------------RENRDT--------------R--RCSS-EKTQF GYSSNRKVSTGDISMETPVPSSTSSSFCTPTSIT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ------------------------------------VLGGKFVDRDFNASTNIVHKF--- -------------LGFWDKKL----------------------MEKKDKMPLK------- -YHFIRVA-- >CMe-1 ----------------------------------------------------EKEVEDP- --GGPVSPAAGKKRKTVPSPEEQEKTKKQKRE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ARRQRLQ----- --------------ERRQYDEMVVKACLLGHIKDPYKEKLREAIRNRVESYSMSIVKASS GLMHLVREMYRDVTDIETVEVPEEFFDKTFIRHLMLGTGETSRRNERVHALHENYAEYRF NGTRYRGDSDIYAYGAMKYLT--------------------------------------- ------------------------------------------------------------ -------------------------------------NLKNHLTMN-------------- LERFMIR--------------AVFALYPGLSRK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GIWAIINGITNDRXHEQEIEFVDKKTSRR-----STNEAS VIRAAIQEHRAVLGLANPAEKVSELKKDKERCYRLILRYFVFLDRELERKAEMELSEEKN EESERRKAAL-MGKRF-------------------------------------------- ----------NVVP--------LCNIKSHFVTIDSRVLHGIMKEISPEFDVSREE----- ---------------------------------------FTGE--------NRETYWKNI FDFKRLKASKQK------------------------------------------------ -----------------VFTGM--------------------------IE-T--DGVAMC VHYRRLKADRPVPPSASPVAKH-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E EKKEADPATQEVQENDFVVGADP-GNTN-IITIAA------------------------- ------------------------------------------------------PKRAED GTDGNLRQKDMRLLRFSRARYYRESGIMNARKKIETWNAGMKEHLEAM---SEVTS---- ----------RGADFQAFREFMEVRVAHWEALWEEYTKPR-------------------- ------------------------------------------------------------ ------------------------------WAR---LR-MNLYCGKQRAFAN-FF---NQ LS-----------------ALKEDESQR--------L--VVAYGAGR-WTTQKGTTP--- ---------------------------------------APTTRT---YKECARRF---- -VTIPVDEFR-T--SYT-HHELGCTLQRV------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EMEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------Q RSPEDIEKYGALTEEQMERRAKVRGLLALVSTTSDGKKRMEFVNRDFNAAINIRRCA--- -------------VLEKRPPE----------------------LTRENFVGQP------- -LKVELYEKK >EHv88-1 ------------------------------------------------------------ --PRNKKDDARVIKCPLDKILKPEIVSIIR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------DIVPVYNRIAIS ATLFLNLRIRQLV----------------------------------------------- -----------------------ESRASSTEFAQFFQANKLVKYFMAVTSSTLGAGDLHA AFGTNFPSVIREDRPK---------------------------AFSQVCMYICRNLEA-- ------------------------------------------------------------ -------------------------------------TATTNVWYH-------------- MKKRVCT--------------VVKKTFGIPRDEWLHMSN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EEKKNHKIHLKQVNVDVLSLEGDAFVSPEQYHDWISNLRSEMKVTHV TRQLLADTRGVDVDDPNVPG------------------------MVYYMKVKPYEFIYAI ATLSSHLNSI-TGGGY-------------------------------------------- ----------ALYP-------IRSSMVPKYLHLDELILADISPGISKGATNTAAGKKRTA DGSELSNK------------------------------DKLVA--------RRMIVFKHV MTPK-------------------------------------------------------- ----------AFNKWENHLGWS--------------------------VD-T--DGYGCS LHVKKKVNE--------------------------------------------------- ------------------------------------LPPSTH------------------ ------------------------------------------------------------ --------------------------------------------------PSIHNGLIKI DAFKDKFSERYSINDLSIIGVDP-GKRE-IVSAVD------------------------- ------------------------------------------------------------ ------SMDYTSKYTFRKTHQDHLTGTV-RHRKAMECTKPQSVFETEQ--DLATTSK--- ----------KVVPVERFMDYATKLATSISSSSGFYEQGV-------------------- ------------------------------------------------------------ ------------------------------YRK---RK-WKRHLRLQKAYSG-IV---NN LK-----------------MVSCHPNKP--------I--VLAYGSWG-MTTSGLPFKGL- ---------------------------------------PPTIGIG--MVRYLARF---F -PVVITPEYY-T--STI--CP-CCD--SN---VTRCTHVEQQRASPFFENGRL------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KEIRGL----------------KHCPG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------------NTYFNRDNMGAWNIARNF--- -------------TNMYQGMA-------------------PIRVRNAAQAAEQ------- -ELTNRTEVD >ESv-1_ ------------------------------------------------EVDTENPDPRA- --KKRCTRKSGVEQSLHAEGDEESSSTRQSCI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CLDLERTLVKSVMPKYIRDRLERMSRYTGS FRYIVGLFSNYVVIRRLEQGLQPPEVKKVFYD---------------------------- ------------------------------------------------RCWAAIN----- ------------------------------------TRISGKNTRNDFSDLLDEFIDQSG FDTSL----FPPRVPCRLQ----ETVTREMEV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SAKNSIVVH-------------- LEAKIKG--------------FLRFRLMNDSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LAFQHLPAKDRSRIIVSLSNDCLEREMRGDLDPGYVPHVLQVR-----DLLAQV YSTEPDVSVLKVLKKKPHLFLELISMISHVAEEASDNNRDLREETKTRSDEEKVRKAFYM SERIKRGLVD-RPKMC-------------------------------------------- ----------TVLP--------VWKLAPCFPYYSSSVVGSIFHKEGHDFSSV-------- --------------------------------------SRFIS--------EHFDLGRVN RK---------------------------------------------------------- -----------------GYKPSG-------------------------FR-S--DGYQVQ VTFMALVSKKPHVPGTKDLAKSGYQIPK-------------------------------- ------------------------------------KVVSLE------------------ ------------------------------------------------------------ -------------------------------------------------TQERGLFVLSQ ARKDSRKIVADRLHAYNLTVVDP-GCAS-VVSVRS------------------------- -------------------------------------------------------CPLEF CRCVGSVRERSTAWEMKGTEYSAKCG-RTMLEGREKKRRSNDEYGRCF---PRFSAVKK- ----------KTARKSSFLAYCRVAAETFKVMFAEKMKRA-------------------- ------------------------------------------------------------ ------------------------------RKR---SR-FHSSRLVQKTVDK-LA---SN IA--------------------ACPSDRK-------S--IVLFGNGS-FRAK---KGHAS ---------------------------------------APRKKL---VRAICSRV---- -NVGMLDEFR-T--SKM--CPGGCG--GE---MTDVQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGQRVR-----------------QCTT-VSVGV ENP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- -------P-------------------------LFENGVAFRCDRDASATLNFCLAG--- -------------YCGLVRKS----------------------WPTHLLRRQ-------- ---------- >ESv-2 ------------------------------------------------------------ --TRTVSVGF----RAATTDEKRDTFQSKVND---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AVD---------------------------- --------------------HLSRE-----------------------RVLASLF----- ------------------------------------------------------------ -------------------------------ANFVFMERLQNGSALPEPDRAFFKSCLSS CILSRGGGSLNADFDRFSEITGLTRLVPPKSMNLDQQREHEAQRMAT------------- ------------------------------------------------------------ -------------------------------------ATSTRATHH-------------- AEKRRIS--------------ITRWFLRGRISRGDLDCK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------KYATKLYKLAEKIITNFDGTPEDTQKLRIMSRAIDPGTDTNI- -----IIDFAWQEKEFSDRDRGDGKSAETIKHLNWMFNTYVAESRRMYE-----EAVSRS HLFAPGKDKACRKKRDEFVK---------------------------------------- --------HE-LGEEF-------------------------------------------- --TYAPPKDTAVLP--------ICSTGAVFIYIDMKTLGSWG------------------ ----------------------------------------LLH--------SNDAWWYKD VLRPFSKEANVKCLVNKENARYASSEH--------------------------------- -GYLSSLLESGPDKCPWMIGES--------------------------FL-T--DGVQIK LLLKTLEHGRKAFSGSSELNEEGYNKLPR------------------------------- ------------------------------------ADVQLE----------S------- ------------------------------------------------------------ ----------------------------------------------------LLGEGRGV YNISSLLKSTSIREDVVVMSADP-GQAK-VINVSS------------------------- --------------------------------------------------------ATAR TWAKQDPGVILKTSTCVFGDDYRRDTLASRSDEYETFRRKGQPYGVAI---DRLGNEKK- ----------RTSCLATFIQYCRRWCVNGPVLFRETLQTGRK------------------ ------------------------------------------------------------ ------------------------------FMR------FDRFRATQKTLAL-IA---DK YM---------------------GHVED--------TCRVMLFGKAS-FRAQKGRAS--- ---------------------------------------APRKAL---IREMASRG---- -VVLMVNEYN-T--SKM--CP-GCG--ED---MVE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DKERRI--------------R--SCKN-FKIGS PEES-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --R------------------------------LHRLTPEFEMDRDDVGSTNIGMRG--- -------------FGKLLGQV----------------------WF--------------- ---------- >ESvi-1_ ------------------------------------------------------------ --SVTSSMDACVREDVPGKDVLLRQIDKDAKS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LGILRHLVS---------------------------- ------------------------------------------------VCLNVLAEKDPS NTLIVNRTFIQQLFTRISG------------------NTLHKSTRPLHHPDLQSYLDESK LDDET----LRQVEKFPLR----CRDALCGEMMT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SIKTHISGN-------------- FESRLVD--------------HLSCRLERRLWECRDDEH--------------------- ------------------------------------------------------------ --------------------------------------------FWASIPRAAKNIYEAA GQKTPEQALSIIRKFVDQKRGSEKELLRLEWGEAMEGLLSEFRGLFEPLRVKRPPPKDP- -----PDHPKTEEELTGREDFLYNVKARLNDVLQIEAGCRKVDFHLRKR-----RGEIWS EVNERQQSIKSSKTKEGFLKQRHLLQEIPVPPWFDEGIEMSKKDASNLVRDVRNTRRDMW KSMKEPGTEH-PPKAF-------------------------------------------- ----------SLMP--------HFSLTRAFVRYDSQSIGTLAKSLDFPGVSENQVTLKTT GVK------------------------------------CAGR--------AERLWWTGI FDFYSERIVNRRPSTEKNQTQRTRKVLR---------------------------LNNRY RKGIGVCNKDPWFTDEVLYSAKRDDPSCETPW------------IVNSIS-T--DGLQVK VCLATLAKTNPLPKGVKELVKKGYASIQ-------------------------------- ------------------------------------DKLRVS------------------ ------------------------------------------------------------ ------------------------------------------------KSSKGVFKEAFP LYDTEKSRLSSPDNHIEVVGLDP-GQVSVYATVRA------------------------- --------------------------------------------------------NITS PETFKASDFKGSQSSISSREYKHQSLTRFSARAEVGRRLDNVEYGQAVQAFDSVSLKQ-- ----------PDSSVAYSSVIYCTLRVRVVELLSEERR---------------------- ------------------------------------------------------------ ------------------------------LQK------FARLRARQRTVDG-MA---RD IAFGNTYRQEVRKEQRSSAEPLSPERRKELLKKIRDKRRVVFFGNGQ-FGHGARGA---- ---------------------------------------CPRKAL---IRALGVLC---- -PVVLVDEFR-T--SKC--CC-SCG--VP---LKQV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DGSRVF-----------------RCSS-QMDEG RS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------PVRYIDRDANGSANIGVCG--- -------------VFQLLGFK----------------------RPSFLCRKSS------- -EGK------ >ADI07872.1 ------------------------------------------------------------ --QAARTAGK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FRGKNKSPKWTKPGDGMVS---------------------------- ------------------------------------------------VMVLPLAVTDPA DLARLNKLFGAMW---------------------HIKRAVQRDARAKVDAYWAAYHERDR DGARA----VRQRLGLSRE----ALERCAYQHLEGAGHLKH------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HASKALAMH-------------- MADEVWN-------------GVQRHLFADSTGKRFGRPKTGRWYDF-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TRIPG--------RARSHTTAN KW---------------------------------------------------------- -------------------------ETFRLVGTLHGHGM---------AY-A--DGGQQE VQQPRRMPKPPLPAGTVPAGKVTASGKPGVRKATWWDHTGPLAVVFAGGPYGIAGDLVLP VRIPQGPGQWA-------------RVEHFLAGSGRWHKVDLVRR---------------- -----------------CKPGTPGGWAYEAHLMI-------------------------- -------------------------------------------------------LGPGY TAPAVEQMRQQAAALERVGGVDG-NVSN-LSIVSF------------------------- ------------------------------------------------------------ --------PTSLNPAEGAPASTEITLTTAERARLEKEAKKRRGRA------RALER---- ----------SRRATNTAQYGLSKKQTRRAERRAAK------------------------ ----------------------------GLREKRVTVPGGARAARADGVPKQAFRRDRLS EGYRELRAR---------------------QAE---AS-ASAAEHRRHCTRL-VA---RE II----------------------AAHG--------V--NLAVEDCD-IRTW-------- ----------------------------YRLWGK-RLSQTTPGMLIAALDQECRAA-GGQ -LVRASTWSTAL--SQH--C--LCG--QR---VNKT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LRNREH-----------------KCVA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GL-VGKRDLVSAALAAFVR--- -------------LTDVDDPK-------------------TAYLDTAMSRHAQ------- -ITYGQGLEE >ZP_03682868.1 ------------------------------------------------------------ --FHKLSDRHILAAETDMSSSDIQKVVKLSDK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IRKADN---------------------------- ------------------------------------------------ELVGLMR----- ------------------------------------KNYDQLMRTKRYRKLLKLY-GSTK DKKKR----------------------KYFAGQLNEMQKQYDVTWDFCRKSMIYIGKKY- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NIDAIFALT-------------- KAEDIWR-------------GMEKCLYGNGNILHFSKYGDLPCIRAKQINRGI------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PVFVK--------DNKLQFKLG RTVF-------------------------------------------------------- -----------------------------------------------GIK-I--NDRFQT DEVNAILDYLAEPEIMNNKAV--------------------------------------- ---------------------QTFMDEAYCIDTYRPCYATLV------------------ ------------------PKLIRGKYRVYLHLTIEGR----------------------- -----------------------------------------------------------A KPKYDRFGNPRHKYGRGMIGADI-GTQT-VAYTST------------------------- ------------------------------------------------------------ --------------------------------TEVGLKNLSERG-------RSIQK---- ----------SERLERLYYRAMDRSRRATNPQNYNEDGT--------------------- -------------------------------------------------IKKGRKTWRYS NHYKKLKEK---------------------HSE---LY-RINAINRQFAINE-DA---NH LR-----------------------SLG--------D--VFITEPRN-AGNLMKRAKETT VN-SRGKFNK------------------KKRFGK-SIKNRCPSGFQATVEEKFKST-GGT -YIEVPNDYR-A--SQY--DH-IAD--DY---IKKK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSDRM---------------Y--HLAD------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GT-LVQRDWYSSF--------- ------------------------------------------------------------ ---------- >ZP_06975900.1 ------------------------------------------------------------ --KRARDTDFLLELPLQVDWSQERQVRAHLEA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARCLYN---------------------------- ------------------------------------------------ALLDEAM----- --------------------------------------KRLRGMRNDPAWAQACAIPRSK KQERA----------------------QAFSTLRKKYRFSEYEMHEYTKQARVSWIAD-- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HIDSTMAQT-------------- LATRAYQ--------------AANRVCVGKAKR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------VRFRS--------KGRGIDSVE GK---------------------------------------------------------- -----------------------------------------------RND-T--GMHFVL DPNAGDGGFLIWNAEVIPAII--------------------------------------- ---------------------DWLDPVVQHGMRHRMKYVRLVR----------------- ----------RKASSPQAQGTDKDGNRYYVQLVLEGR----------------------- ------------------------------------------------------------ ----AFVKPRHEEVGKDIIGLDI-GPST-LAMVPR------------------------- ------------------------------------------------------------ ----------------------------------EGKADLVTFC-------EEVAP---- ----------DTRKKRRLQRKMDRQRRANNPENYDEKGR--------------------- -------------------------------------------------VKKGRLRWKES KRYKATRRQ---------------------HAN---TE-RKLAAHRKSLHGN-LA---HR IA-----------------------QIG--------T--TITLEKTS-FKAW-------- ----------------------------QKQYGR-SIGLRAPGVFIAHLTRIVAKT-GGT -LYEVPTSSTKL--SQY--CH-QCR--QY---HKKP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LSQRWH-----------------KCP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------SFGPVQRDLYSAFLLAYLE--- -------------PEQTIPSV-------------------NQHVWEGAEPRLR------- -AVMEDLQQR >ISCbt1 ------------------------------------------------------------ --AKSKTSSYILTLKLKTEKYQEDILNKRLEI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SRNIYN---------------------------- ------------------------------------------------SCLGEIL----- ------------------------------------KRYKHTRELKDYRKEYKNIIKMSK DKERS----------------------KKFNELNKKYDLTEYSLHTYVKPIQKHFKD--- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NVDSFTAQK-------------- IATRVFN-------------SFQKLMFHQAKRVYFKRYGELNSVEGKSNKTG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------IRFQD--------NSLIWNGLK IP---------------------------------------------------------- ----------------------------------------------VIIK-T--NDIYVQ MSLENRV----------------------------------------------------- ------------------------------------KYCRIIR----------------- -------------------RIVKGKIKFYVQLILEG------------------------ ---------------------------------------------------------IPP MKINKTTGEIKNKIGKGNVGIDI-GTRT-IAVSSE------------------------- ------------------------------------------------------------ -----------------------------------NDVKLLELA-------PEIDN---- ----------IENQKRILNRKLDRQRRANNPNKYNEDGT--------------------- ------------------------------------------------INRNNKDKWIKS NRYIKTQNK---------------------LKE---IQ-RKQAEIRKQSHYR-LI---NR LL-----------------------LLG--------N--RFLVETMN-YKGLQARVKETT INEKTGRFNK------------------KKRFGK-SLANKAPSMFLTMLDNKLKWN-NTQ -LFKIDTKKCKA--SQY--NH-FTN--EY---CKKE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LKDRWN--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EDIQIQRDMYSAFLIMNVV--- -------------GKTLDKID-------------------RDLCIETYDNFRR------- -LHDKEIERL >VCa-1 ------------------------------------------------------------ --HGCNAVAL----SVVKCALKKAMSLTDEEF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GMFS---------------------------- ------------------------------------------------AQVEELV----- -------------------------------------QRKRVTNYQPGARARITVTRDKT TKEEK----------------------VTLKVTGYEAKVTEKEVSDFNQPDGLDQVIQYA GIGFKT------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VVLNNVWYP-------------- LFARLGR--------------LTKAYMHQMCKKHHHKKTPWSKAHAVVQLIRSGKPIPAW PAYVVAYIKNARAKLLDAAGSTMYGSLNGHALQARQDELLSAHENKYLWDDHAKKKMTFQ AAMQFN------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------FW-MQKQF-------------------------------------------- --ESLHQKKMRLMP--------VFAVKRSHVRLDTKSLLHIFCSLFPNDHN--------- --------------------------------------VKLMK--------SFWNQDAFL EKCGLPGSAHPDTYMLPPKPPDGTTDKALLAQYQSACSRIRNTDAYRSQQARHRALSETE DRVVKSFFRCLPVKNGYKFDCS--------------------------IS-T--DGVAVS LQYSKPSKAVTAKRKRSAGM---------------------------------------- ------------------------------------RSSNVA------------------ ------------------------------------------------------------ -----------------------------------------------------------T DAYDQNLDMYDPEEGVLTLGLDP-GRCS-LATVSV------------------------- ---------------------------------------------------VTQYTLDST GKLKLGEKLNRHSWSLLRGEYQHKSGIRTSTIKKAQ-RDAPLQPAFQA---LAVPGCAL- ----------RTAQSGTVLRYIADSQHCMNEWWERAL----------------------- ------------------------------------------------------------ ------------------------------SRQEAMAS-FQGYIGKRKALDS-FF---SR VL--------------KEAKKLVPKRTK--------I--EVAYGESG-ITMSPAGKGEV- --------------------------------------AVPTTGT---FKACQRCF--GK SAVVPTNEFR-S--TMM--RW-ESG--SK---THAVY----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KEFRAA-----------------EGQD------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C---------------VKEVLHGTDQKHGGRARTSNAEGPSLELQRRSSSQ QLAATLHS-------------------------QWFRVTRMYYNRDTHAASTIGRLR--- -------------IMERKGLG----------------------RPAPFCREAK------- -A-------- >AMa-1 ------------------------------------------------------------ --DQARAPIV----SVVPQTLHHALVDAPEYL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AVRAVIEARSER LVNAHGFAATEAT---------------------LYLRYRARRAYEDFRDALLYAEEDYE SSNDM----------------------VSLLKAVTVADQQADYLVFGIPNCDQLDQYATE YLHHVHYPNTPFVNRSFFTRSFEYLFQEIVKNGSEHFHRTFRYAAGRCINPFAVLVESWP PPAPPRDQRAVEPPANRRMRRDFYAAIDKWVTTICRRGSKLQLDKFLYKCACIIVDYNLF ILQNPEYARATSGLVPDLGVLHVPVPFVPPPPAAADDEAQGQVEQQDSVHLPRFIPEGVR IAAETLP--------------RNRHARRKQGKAWIAPAV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AD-HFAVA-------------------------------------------- --RRWFCPDLTIFP--------HMALKRRHVRLDSMDITRGLL----------------- --------------------------------------AEFPG--------NSPDLLHVV FG-LIMKHAHLDSLVPGASDLNVPDEQYELALEQYAWQKLRDISPQLARLRTKFCSDPSI SPVLSGYWQKPRVDGAPRVGS--------------------------SFT-T--NGYAAH ILISRVPTDDDVRRVGGEGEIKQKSTRRVVTRGPGRAVAA-------------------- ------------------------------------KSLHSR------------------ ------------------------------------------------------------ -------------------------------------------------------LGTGE FAAIKSRSLIVSDYPKGLIAVDP-GQST-LMTKTT------------------------- --------------------------------------LTPFRVGA-----FANGWINIK WEITRRRNPGYKSWSIPGPRWSAATGQRNQTLQILRLRQHQSDLEQIE---SRLPAV--- ----------HDPTLAGIIVLAKAVTTNMERILGFKMDRR-------------------- ------------------------------------------------------------ ------------------------------YAK---YD-LQATIAKQRALAY-LR---NK FT---------------------------------GY--GVLFGNKG-AVQINRVTRM-- ----------------------------------------PVKGV---IRYLLVY---GI -DVLLVDEHR-T--SKF--CA-VCG--SE---FEATPAMKVNRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FAYRYL-----------------HCPS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------KY-VVNRDVNASWNMFRVA--- -------------LRDVFDIYVADSMLKHPLALLPSR---GAPRPLLPQPGDD------- -DFDDSAHDR >MCi-3 ------------------------------------------------------------ --DFRKTLST----KSLPNKVVSKVQVQMEQQ---------------------------- -----------------------------------------LGNIQPGWVQAVIQRLRTA KTMPTAAQYVALFIKDLKKELETAQNGEPSTSGTSASGTSASGAGGSGSDQVIRSVSRSL KAVLHPSFDSKVFFEVIKNFQASCHLCIRGLSKAIGVLIDFVLRGQLGGKTKATFFNVED VDLFNCGLGKKA-KPISFINDTDAGALQGLFDYSGFWKTLSFCIGRKN--EDKTKIPKCR LLVRIQEKLDRTDYVDFTTRSALQEACRMYYTNFSNIYSQKNCQAVLRTVLTLLL--KIN LCRERLFGDKKTR---------------------TYKRKQKKGPKPQSQQATKKLAMDKL FWLLG----------------------SDCQVDQCIDKQMRIIFSVNKKKPNSKQLAAPS TPITPSSVSSKGKSPMQATSSSCSLSTANDDPNIELVDNDDSDLESVIDDDIQDEEEYRD LTAKEINALTSVSMMLCQSTTIQGNVSAQYVKQQLYTDKRDSIPAIAIDHCCAIIN---- -------------------------------------AIKSLVPKE-DYPPSYKWFGLFE LHNTLVT--------------FHQGITRKNPRALFPTVD--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NP--------HNSQDRMAIALDAATLYSLFCKDYRIYQK---DK---- -----------SEFTSTGMI-------------------KTTQ--------AKEDLFSNF FNMPKI------------------------------------------------HKILRE QKLTFCHYIKFKDLYNVHLVGVKTLGSSSS------------------------SGIKST IDKPDPKPHVPKSSRSSSKADVIKANTLSSTLKETK------------------------ ------------------------------------KKLRPLK----------------- ----------------------------LQLSKLQRSRMDAGHASRSWEKTNKALDWDLY SKLKEARKKHDTLWATVSSMKAQIKQMSSDLYILNKRIHGQQE-PQ-------------- -AADAQTPQLTIDENTVIQGTDP-GVVT-TASSVW------------------------- ------------------------------------------------------------ CSSRTLFASINRYQVLWDDHDTKPPPADQKQIVKSELTAKKIDTAVLSPRRQKRTRS--- ----------SGKTLQKARA---------------------------------------- ------------------------------------------------------------ ------------------------------TRR---IR-LKKCHQHFVAAEA-KS---AD IF------------------STGQKPRR--------M--VPFIGNWH--RNATHLRGH-- ---------------------------------------CTRSMKPY-LSNLSTTS---- -TVAFVDEFN-S--TKI--CW-ACF--HE---TQKQLMRNQEG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------HMTRNL--------------GAVTCYN-TK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------PMRASKQTTSNRDAQGAINIALIG--- -------------FSKLVSKD-------------------GSVLPPFARKTNH------- -DK------- >MCi-2 ------------------------------------------------------------ --DFKATLSV----KSFPENVVQRCSDAIENK---------------------------- ------MRAAGTPLSRNPQWLSRKLHSWKTRKKNPFGVVQLVEEFIAIITKEQNKELADQ GDDDPIEVEDGTSQDQDDPIEVENDISQDLDDPIEIEDDTAQVQGQLVPIKEYHTISRSL KSVIKPQADYQTLLLRMTNLQNTCHHVVYGLSQCVSTLVNMIIEGECSAGAHPGYLDFSR IDLHQRGIGAGAEQAISLVAPIKQDVLD-LFNFAGFYKIACAVVGQKNLTAHSADFP--- --------LPANDRVTFVCGPWVQDACRRFLTNFINMWSPASCVADLRVVMEMLL----- RIHLCSQRFFNPK---------------------VRPKKTKKQNKVKIKAPSKDYAMSKL FWALV----------------------HKDPKQHVVDFFTTKVFKLFPTPKDITTAATVS ASASVAT---------------------AMNPYEKALQDGTDASEDEEEEDGILLAQTPD LPAKDIRALTSVACFLCQSPEHPTVITMQHVKEKLYHDKQDCIPSSALETTASLVS---- -------------------------------------AVRSVTPKEDQAFSLANWIPMRA LRNTLVE--------------FAGSKTKRRVSKLCVDKK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KDTNSADAVRIDHAALYHLFSNDHNLHLPNGIDK---- -------------VTSVHVL-------------------KTTE--------QKVDLLNNF LKINKI------------------------------------------------KGLFQE RKLTFAGYFLFSNQYDLHFAGYKIV---------------------------QPVKQADI ATRGRQERSGNQNHEAEKQLVKELTKEIKDMR---------------------------- ------------------------------------KTYTANA----------------- ----------------------------KELRKLELARMQAGNKSRTFERRNKRRDPNLY RDLKDARDTFNKLHAKQAKLLQEIQERQSRMYILNKKIHNQRHPPQ-------------G SHLDPKLAPIVAASSTVVQGIDP-GIVT-AASGVG------------------------- ------------------------------------------------------------ TYSRSLFEAVNRFQAISNEEE-VPHPKDQA--YPFSLTANMVNTAVLSHQHRKQREK--- ----------KDIGIKKQQRNTV------------------------------------- ------------------------------------------------------------ ------------------------------IRR---CR-LKKYHQRKVASDN-AV----- --------------------YHQPKGAH--------I--VTFTGNWS--GSGAYIKGH-- ---------------------------------------ARRSTKLY-YSQLGAGT--NH -SVVSVDEYK-S--TVT--CS-SCF--HR---TSKQVHLRDG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------HIKRIP--------------GAVVCLN-VK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- -------P-------------------------RRLTSGATTVNRDLNGAKNIALIG--- -------------FSSLAAQD-------------------GLALPPFRRSHNT------- -N-------- >MCi-5 LPPPLDQGFLNNAPLLEQARNFLNDQHLDRIFTAYFGRTPALQVLQRYPLHLAVLQTLP- --PPAEAP------PIAFSHAKIVARNKFKTN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------FENLWNLKGRFTKVFN---------------------------- ------------------------------------------------KLITTLL----- -------------------------------------RFHLAPEREAKYQEYLTSRTQDQ GSSTP----TPAQAPHGEI----TFAGKTTNEIRRIFHHERRNQQNYTDKAKTEGARWVQ KAQRSAHRLATFTAVRL------------------------------------------- ------------------------------------------------------------ -------------------------------------AENGDLSAR-------------- AIRVLVA--------------AMRNVIFTLHGQAGQVTR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------A- -----QFRRIAGNTINGNTLEVCLNIVNRLMPYIPSRQNWFSKLHQIPF-----ILLANE VFRATGHAGFAVK----------------------------------------------- ------------------------------------------------------------ ---------LTNLP---------STSSLLALELDGPSLYNTFSVQQGDRRVL-------- -----------NLFTYDGRIITEDV--------------TARS--------NDDAIFHSF FDLEKI------------------------------------------------NNILAP YQLQFRHQITLLPGLKTVRLLGSK---------------------------R--DNATVA HAALPFVEKKATAPSKPPPAREQPTDAEKREIERLIALRTAEVEALARRLKQTMRERAAF LTNEYPYV----------------------------KKLKAT------------------ ----------------------FPNQHPTQDFPLTFRATRNEMYQRIRQLKLRRDEFNQQ AAAIKHNLAIQRSTLHRLRKGLSIDPPETREAPPT-------PNI---QITQDRYQCYEK AENVRLHPALHNSQNMRFSGTDN-GIVTMTETVRFDMPRFRFHLQLANTFEALKDLRYTE ANP--------------------------------------------------------- --DLLRVPKAHKMYATDIDFRTGAKKQRARL-YREKHSPQGLPVVQAEAILSQNSLH--- ----------DAQNLDEINARYQAQLGERNTIRHFYYTPA-------------------- ------------------------------------------------------------ ------------------------------KAR---QQ-RQYEYCNRKQIDR-LC---SE ERKYV--------KSDDGNYNRERDRHHQ-------T--IHFIGDRG-TGVGSRIKGH-- ----------------------------------------LRYGGH--WKSRKHSL--NT -SVCITNEHN-S--SQA--CA-FCF--DK---VTHPVKMVKGEL---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KTINGT--------------A--VCSN-PR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------LLVINKRSHQPRDSQSSLLIGLAG--- -------------LCTVLSAR---------------------TTFPALDPKNQ------- -DISQSNTDF >MCi-6 APPPLTSSALKSATFCNGIDDLFQGKHIQYLHSSLFAERGAKTSHSTFDALSSA------ --NVTVLETISRDTPRHSSELMKVALSLYKTN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LKNMWAKNKLFNKALN---------------------------- ------------------------------------------------KLLEILL----- -------------------------------------RIHLAPKRESHYQKLKEKRAKKQ QAKNT-FDAVAASTTGSDV----DIDDMPIEELLPHYEVLDKEDEEGEQGEQAEEERGKQ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TGSRDLPRR-------------- RILVLKA--------------VLRKLLVKQAGKAISHAQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------LKKERRDITDDEARVCLLLSEILLPYIPAKGHYSYIGFQLPF-----VLLAND IFRAVGYGKFAVD----------------------------------------------- ------------------------------------------------------------ -----------LCP-------TSSCGSLHAMRLDAPSVYTLCTKGDDPV----------- -----------DVFDFEGFHIPSVA--------------EARA--------HKHAMFNTF FDIRAI------------------------------------------------FKACDT FGLTFANNLTILPGLSSVRILGTKKNSSKPAYSMKKPLDIDWKFVNDAQSKT--DEELRK DIDTLEADMITLSEELKSQSKDHNHEELSSKI---------------------------- ------------------------------------KQLNRQ------------------ ---------------------RGAERTLHDRDPCSEIADLKTQRYQSFLAVKRTKQQLSR LRSRAFLTRKAIEYRNKEIP---------------------------------------A AAVTDPPPSDQELNAMVFSGTDN-GLTVMTETVAMDINKYKYHLSLHNRFSPLANFDINE GDGSEGANAATSDIDKDGDQASSGDSSGVDALRGDAVTVDTSAVPQTHDDDAASDGASNH SATFQPLPTSYKMRAEDVDFGSGQFTKRQIILKAKRTTEQGKQVQQMEEQLKTSNVF--- ----------RAKHVEDVMSNLAAYRNNGPALRSFYH----------------------- ------------------------------------------------------------ ------------------------------SKKMTILS-NKVEHTDVRFRSR-FA---SR ERSFC---------------AGGRPQTH--------L--TMFIGDRG-LCVGSRLKGH-- ----------------------------------------MKYGGK--WKPRLHSS--VA -KVHTTNEHK-T--SQT--CM-YCF--GP---TSHLVQTIKAKDGKTRT----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KLTNGA--------------F--LCLD-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------VSVVNHRAIQGRDRTSAMAIAVSG--- -------------LSSLLFNQ----------------------PLPVFNPKPS------- -QSNTGIISK >ROr-4 TITPLAMDVSDSPAFDADFSQLFQEQHFSLISTKYFGNRGSQDQTLNAHPIQTALFKLM- --DAEDIKKETFPVENVPSSLMSLALQIYVTN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------FKNMWADKTMINKLLD---------------------------- ------------------------------------------------KLLVTLL----- -------------------------------------RLHLAPKRELQRRQNILNYISRK PEEKR----------------------PSKNYGRYILRAEKKKLARYKEKKQDASSSSRE KSVESTTTTKKET----------------------------------------------- ------------------------------------------------------------ -------------------------------------TPCDDLSRG-------------- RISQLKS--------------GAKHLIFSKDLVTEKDVN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------DEFPDATRKEVSVCLLIINTLNKFVPVRSKYHILPYQLLF-----CIFAND VLHYAEYSKFTRK----------------------------------------------- ------------------------------------------------------------ -----------LCP-------AMSSAHVNALNIDAPSLFQIMKSKTDDNQGQVEGMSTEL -----------TIYGYNEEPLSSV--------------EIARR--------NKDAVFNSL FDMEKV------------------------------------------------RHTCES NGLKFGQRMSVLPKLKVVRILGVKKTTVPPVKP-QKMSYLKRILRDPNIL-R--EGQKPL EDLKAETAKLEKEVKSLDQEREKALKCQKEQDSI-------------------------- ------------------------------------KKIKAL------------------ ----------------------------------------RKEWHNKVDKQTLYQRIEEE RHLRDKTYLKINDIEDQLMEKKQVLYYQRMAIRHNSRIHTVDTASA-PPTTKKELKKDSR GLVHSEACVLRDFEDFTFCGTDN-GLVNMTAAVPFSLKRFSFHLKLHNYYSVLDD----- ------------------------------------------------DNKAAPVVQDIE LQKYLKTPKATTISASEIDFGCGAFKQRVKRQTGKKLTRKGKEVQLIENSLSQKVTST-- ----------SNVSVEQFKHNFDAHVEHRKKLRDFYNTGNRM------------------ ------------------------------------------------------------ ------------------------------NER------RHREIQKHRFTHR-IC---TK ERKAL----------SQTSGNNPSTKKK--------L--VMFIGDRG-TGVGSRIKGF-- ----------------------------------------KRYGGR--WKEVIHSE--AA -NVCVTNENL-T--SKT--CI-FCF--RR---LTHPRISVTKNGEVFS------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RKVKGS--------------F--YCTN-PL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------VSVLSKCAAKSRDSLSALAIGIVG--- -------------LSTILFGA----------------------PLPAFKSHKI------- -SNIEAEKYI >PBl-3 TIQPLDKDLIASKRFDTDFKCLFTSQHLQVVHSYFFGARGAKEENLNAHPVQNSLFCSF- --KESGLDKQSFCLEKASSSAMSMALETYLVN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------FENMWDGKKIINKLLD---------------------------- ------------------------------------------------KVVLVLL----- -------------------------------------RHHLARNR---ESKRISTTTTRN PPGKK----------------------DMRNHARYVCRAEDKKLKKLVQRKEKAGGLEGE KWATKINSAKQRLANLRHTFKKKISQMLNDRKEASVEHKLVVQDLNIAEEQQDFLEEEG- ------------------------------------------------------------ -------------------------------------TLDDDVPER-------------- RLNQLKS--------------VIKHLVFSNDTPVYLEDV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KHQSPEATTTEQSVCLLICNTLMKFLPPKKQYHVIAYQMYF-----CIFAND VLKYARYTKFTRA----------------------------------------------- ------------------------------------------------------------ -----------LCP-------STSFSSSSALHLDSVALYQLLTQNIDQEKSEEPPSHTNQ QEKKGYSRM--ILYGYNRDELIGSQ-------------DKARQ--------NKDATFNAV FDMGEI------------------------------------------------QKACES YGLSFAHRMTCLPGMKTVRLLGSKIKTHGTVKEGTKQSYEARILRNPSIM-Q--EGRKTK DVLFSELQSLTEEVKTLESVRKRELDLLKDSNFQ-------------------------- ------------------------------------RKIKEC------------------ ----------------------------------------KSNWGTTDDKDQLYRTIEKY KESRYKSYLTVNKIRNELAEKRQQLYFRQMAIRFKSKLHNVKDVPQ---DSRSPIEKCGK GVTKAEDRTVVNPGDFNYAGTDN-GLVNMTASIPMSLQRMKFHLKLFNYYTALSKV---- ----------------------------------------------SNEDSIGLN-LSKE EESFLHLPSVTNTKASDVDVGCGYFRQRKYLERRKKYTDEGKKVQLIEDSMREMESA--- ----------PVTSIDMAIRNFRAKYDQRRSLRDFYNSPKII------------------ ------------------------------------------------------------ ------------------------------NQK------RHVEIQQHRYRHH-LC---RR ER-----------LELKHSENKSSSKKP--------L--ILFIGDRG-TGAGSRIKGF-- ----------------------------------------RKYGGK--WKQKIHGE--AV -NVCITNECK-T--SQT--CI-FCF--SP---LTNPRIPGKKEGSY-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KVNKGT--------------F--LCIN-PR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ---------------------------------ITVKNRCASKPRDALSALAIGLVG--- -------------LSSVMFGA----------------------APPPFYNVSQ------- -ITAEHYTKI >MCi-8 VPRPFDAACFRNQAFKKDFDLLFQTGHFNIINSSLYGTKGPTDANLNKHSVHRLISDAI- --GLAPTEAY----HHLPSHVTKMARLQYTTN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------VKNMWSDKTIINKLLK---------------------------- ------------------------------------------------RLIKCLL----- -------------------------------------CIHLRPTDEKQLQERRLQPRQAA PRSSN---------SNQGM----SFSHKTRNGRRRVINNEKKNLERCKRLNKVDKAARCE ERLTMYADVMERERRQKALRRQASSSLEEGVSEDEEDALVADEPES-------------- ------------------------------------------------------------ -------------------------------------EKTNDTSKR-------------- RITQMLN--------------QIRSNLFQNTPLSRSTVG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SKIENLSDSEFDAMSIIAGFIKPYIPAQVDYAKLQYQLPF-----LLMANE ILRYMGRSSQCLQ----------------------------------------------- ------------------------------------------------------------ -----------ILP-------LVKPTTLHTFLIDAKTLYALFCASTLQQPM--------- -----------ILFNFQNEPIQEG---------------MVDS--------YKDAVLSAF FDIAHL------------------------------------------------KRLCER HGNQFARRLHIFPALTTVRIYDTVPRLV-------------QHQQPI-TA-T--DGDPID EDHHPDLQQQNDAVVRFQHELKDATARLETMLLMSPSV---------------------- ------------------------------------RQLKND------------------ -------------------------------FRGGQASFKTVEDAKTTKRRLMLDVRDAK TNLQIARREVQRLKSMHKFPPTLP------------------PNY---QRYMIRQQPCLK KAEECFIDEDFDLQGAIFAGTDN-GIVKTTETVYFDIERFLYHLRLFLHFHPSDQNGQPV GAPAMFMDLP-------------------------------------------------- -----------ATLTIGSKEIKQGSGMFDYMRSMNKKKTPGEQVLAIESTLSANSLF--- ----------NCSTPNELEETAHLHQRHQQAIRSFYYSNIQC------------------ ------------------------------------------------------------ ------------------------------KER------RQFEWRKERYYDR-LA---SN ERN-------------------SSGVKH--------P--IMFIGDRG-HGYGSCIKRH-- ----------------------------------------LRFGGH--WREERHSR--YT -PTIITNEYN-S--SQT--CL-YCF--NK---LSHPTFAHNNAI---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KTTKGT--------------F--VCLN-ED--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- ------------------------------------PNAFVSVCRDQVSALAIGLAG--- -------------LSQLLFGA----------------------AFPCFDEDTN------- -PMNKTRFYE >ZP_01624251.1 ------------------------------------------------------------ ---TVKVFEF----KIYPKKEFQEQFNRWAYG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LKKFYN---------------------------- ------------------------------------------------FCLEQFELLDEY TYWDKLSKTRVPCCPIPWNLKLIETEEPNPYLPELKNKHYVSYSNLIAPKDIPVIRNAPE ARQYT----LKEGETAKDV----FKRVKNPDKIVVTMAKPESSGLDKWPRGWLGGVGYSQ PVKQDYKPSLIKNFPNSEKTRDAGILVKKETLENSDLPDEIKKAIL-------------- ------------------------------------------------------------ -------------------------------------DVPYKFRTG-------------- TLSSLCT--------------SWQEYMKSRTGQNDLKRGK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PKYKR--------YRDRIETII HP---------------------------------------------------------- ----------------------------------NPNAGSSKPASKDACR-L--EGDNIL VLPSFGKIKIKGLDRRFRDNDGSIPRV--------------------------------- ------------------------------------KVVKVLK----------------- -----------------------RPSAWYVQLTA-------------------------- ------------------------------------------------------------ ---DINRSNKLFKKPLGAIGIDT-GLKEENWITTD------------------------- --------------------------------------------RFSVTKPRWYRESEEK LARLQRELDAKKLQRVILWLNHPENSTERIKEVFPGISKESIEK-------VKGCK---- ----------RPQDLQDLVSNNELSTSGLNQ----------------------------- ------------------------LKHFN------F-----RDCEKVESCYLFDKLLSVS NKEIELAER---------------------IGK---LH-ERNKRRRRSHNQK-QS---TW LT-----------------------RKY--------S--IIRIEDGL-QKNVGKSKAKIS EDN-----RSFER----------NAQNSRAGMNK-SVLDAAIGGFISLVEDKSKEW--GR -DFKRMKPGKGKAYSQR--CP-VCH--HE---NKEQKDI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TNHQ-D--------------Y--NCSN------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GFTHRSRDIVPGVNMILDE--- -------------FEAGDIQW------------------DDLSKEARQAWRLR------- -EKWLSENAP >YP_700601.1 ------------------------------------------------------------ --LRQFSFTT----RPYL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AVD---------------------------- --------------------DATGAPIGLDDLDVRVGWMLDLISGAEAHLLSRLWQPATF DVLVAGCDSRGRK---------------------LPMQGHVAAARLGWTPHYPDGV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------YVPSRVTRV-------------- VTAQAVG--------------TLRALAYRDTAITALS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ARFDP--------ATGRIAAPT TA---------------------------------------------------------- -------------------AEYVPCGYA-------------RGVVRQLTA-R--SHRTAG VAAERLRITDVQAPPQTSAMARLSAADRQLAHITVTDAVMTLTVTLPTTPAPEGRAQW-- ------------------------------------RRVRVT------------------ ---------------AAIPPHLHARPISEWHLPTLHLDHRGLLL---------------- -----------------------------------------------------------R CAANEAVPVADMRSGTTAVGVDW-SPST-LGAAAV------------------------- ------------------------------------------------------------ --------------------------ATETPDGLVSDYRG-FTY-----DDRGLGA---- ----------KLARLQTEGQMLHRKAARLTRLAATAPPEVR------------------- ---------------------------------------------------------AEL EAKIAVLDE---------------------HRT---AVGAKRGKINRELAFH-FA---RQ AT------------------DYAVDAQA--------Q--LIAVEDLT-TLETRGH----- ---------------------------GHVNNNR--AAQSARRQAVVALAHTAAEV--GI -TVVSVPARG-S--SAL--CP-GCD--EP---LARP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGYH-D--------------A--WCTR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------KV-GGNRDHIAGVNLAKRA--- -------------LLGKNNVT-------------------PRRGQLPAIRVAE------- -HAPVRQCRH >DFa-1 ------------------------------------------------------------ ---MLIQLKSLGDIKTVPSSLIFSPLGSRVVLIPLPCLDMLKLLRTSACSTSSPFVCLLN RNDVLFLMRCTCLNENVGLKRSPINLFFFSSHHYSFYLSFLQFIIFLLYCITFIYFLYRK LLIEVHYRTVVIMNGPLPSATETRTTQYPLDRLMGKKWNNEQNLFVTHLGQYARYYHSVK RLVGQFFLIFVYDFNN-------------------------------------------- -----------------------------MFS---------------------------- ------------------------------------------------LSRQELE----- -------------------------------------KVIPKYYDMSVLSKNKTNELYEK MENRLTLPIRWDSLIVEAI----ISKVMDIDTRKSSNSPRDYVDEMVAKYQILRYALLDP DLNPIGCCHSYKTAFAN------------------------------------------- ------------------------------------------------------------ -------------------------------------SICNSYSAE-------------- VAETCKR--------------MVESALDRQDDRNIFHHESKLVSDLLEDILAKIDDGDIG EGYQALKLIFSSQPLKGMSLILTPSQVFFKYLLAFNSTFIPFSIELFVSIIVNSGIDMSL GLTDKHKILRYISKILPNLEKEIGHPLESGYPLDRFKFFDKEIEILKASHLASFPSSSDS LASTKKSFLFRYYTIGFVGKSVLCDYLQSPYVKDNPFDFNGSTKTIHPNFNDYERDNIG- -----YIYNQKMSVLINQRAMMVTTNVPSHIWFQTKKEMEKNHSYSYNH-----PHYACF VAKQVGLKPNIPKVKDRDIICANCLSSHSLKDLPMVCEQCDATIPILSEHEKRLDLCGDL MDLYSVDIQL-KRNAF-------------------------------------------- ---------------------------EKMPPFDSKDDLFPPPVPLIAEINHRL------ --------------------------------------VKFDQ--------PESPHVEIF LH---------------------------------------------------------- ---------------------------------------EALNTTSIALN-S--NRSGIA PSMRNLFNLIKTTSDPSMQFRIRDAYPFVHDSSTGGFENEIK------------------ ------------------------------------HEIMVK------------------ -------------------ELMNHFSMTTSKLIIVCGQFPCKAAKEAFNANPLDYEMVDY SQESYHTILDKAKG-----TTEDKEVDCVYKDEEKHIRAKRDFY---------HSGMCRR RRSKWKVMRENNRGNYLYIGIDP-GRSK-CTIVDS------------------------- ------------------------------------------------------------ ---------MNRARVVSVASYYNLMGTDRLLARQQNYK-KNPVLSKFESGLPPYNTFD-- ----------TLFNVESVLRRIEYERITHRDQCRLYSHVVTSYT---------------- ------------------------------------------------------------ ------------------------------FQT---MD-KNRNIDKKRAQYA-YA---KS FV-----------------PPTTIPKNR--------I--VIYIGGSD-FFRGSRGGGR-- ---------------------------------------TGCTSKT--LLRLFLNM--GY -KARLVNEFN-T--SKI--HN-ACA--SK---IHSTNNNKFLEKAKHQKVKNVLPESFEK THVVGAPISSTFSD---------------------------------------------- ------------------------------------------------------------ ---------------------------NGVRWQGKDSKLCDGCKLTDYNCQCSK-AQLAD KENDSTLKVSQLADDMNETLKVFISLENTSPSPTMLLESLFSLSKKTVKELIEFCNLNSI KYNQQEEPTKGKNKRGSHKDSKGGATNSKKDQLINAIIKFNFEKQKRDASKNKKKRSKSS STTNDRCKDQDQSNSQKDGNKSTSNSVSTHDYGFGKSLCDSQIKDLWKSMNPNATEMPFK TKWQWLY--C-------------------------------------------------- -------P----------------------------VCDH-FFNRDTSAAKNILLLG--- -------------ILHQTADY----------------------RPWIYRPLPA------- -DIVHIGRVD >DFa-2 ------------------------------IRYFALGGDAIFSAMGKHPVPRIDTVEDL- --SNDSIYSLCFFMKHVAPFLEKEMQKRPKML---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QMLQKLRQFRCN NSKNWVNVIVI------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NIKNNIMVS-------------- TYNHLKQ--------------LLNTYKDRKIKDLGKNQE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------EIKKVKKLVRDTIYNFSNTRLKRAEKDQQPVQEEKKADRVVT-----YDLSDG VYKTIEILGGYNQQVIDEYNNLSDDKKPKGKFNQRMKHDSIRIRELDELKKITIEAEKRN ADLQQISDTR-TPTVFIPGLINISSIIPSLGFDIQFMFTREHAKNLLKCLGLKKANVEKD HEGNPSYAIATLFPG-LYKYDPRLFTNTKRVYLPATPPTDVEKQKDEERRKTNNDNRFAS ALKKYKGNEDVARVAATLQTGEKAKNA----IEQHNKLHGFKK--------GSHDKNRAL LA------------------------------------------KGTITFSKEEMFQEIV NKGVKYENTSTLPYVTVTFDKKV------------------------SVT-T--NGASAT VTFRTIKYKPGNKPNKLYN----------------------------------------- ------------------------------------KQVAME------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KEFAGKSLKDVIAIGIDP-NTCS-ITVVNN------------------------- ------------------------------------------------------------ ----------HDDKVLDMRMDTLMVKRNTKFLLEKISCHMGKAIKSFE---SCLPSLKF- ----------NVLNPQTFQSRLDYYEKYCDYFDIYFEAINDPIVLS-------------- ------------------------------------------------------------ ------------------------------WKRNFA---FKKQKLNKEFYQQ-FD---NY ILDLFKDHFPTKYSSMNDSERNQYIQDN--------T--IIFFGNAK-FGHNTRGKVTTF ---------------------------------------AAKTVA---NKLKSKQY---- -SVVYINEYN-T--SRQ--HF-DCFFHQE---EENLIHHDLNEPHEDPKDGFHLEKCHLK LGKEKDGGQPTNVQQCSPISEACQSAAKGNSFLRCSDHRHRLALVKQDTHSKEYKESLGF LKSIDDLDKKLQSHNLLNVAGQCRTRKVTPSDVAGSETESRQDSQKVASTQSSSSSTKKF DYRHGQNKYGPEIRKASKSLHNKHRMAVSWKRV-----------------LCTG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GK-SFNRDVNAARNMLLLG--- -------------IFKVWKNG---------------------HRPSRYGKTN-------- ---------- >PPa-1 ------VNQIVRDHMKNQSNLNLLNIERISKHIMELNGFGPIVTSIKKYLLAKPEETVD- --SALREPSILIWLRQHDATITKESFDRFKSF---------------------------- -------------------------------------------------KNDFETYLVPV TKSSETNCTSALEFIQSILNHPTIIFNWNQHTINQFQNIEKEFGKYHNEDNYKTESQAWI NSIKQPTSPIPLKNNNSRWIKANDNYNKLIIINEFIPKFKLAPRNFILSTKFLQQFLQQF YNGSDFNREGSYLDHLSLLINIPEQFKQNFYTFKHPLTVCQFNLDRVSHCGHVPPVDSVD HTNAHTICMFAASNNLTLTVPKQKKVGAMLCPEHSTFSKKCKLSKCGSRCISKFKESEWR IQSIRCGSLDSEP---------------------HIEKKNQWIRDLSKPNSIIEVTSQKQ TSINW----------------------TSTNASTASVKPNQEHFNSPFFVGCDINYQGME SIPPNCDIG--------------------------------------------------- ------------------------------------------------------------ -------------------------------------VIFSDPTSKWHVGLTADDTDFNP SFKKLGK--------------IINTVFKDKK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VLPKLFITNSYSSTN-----YSPFGI PEQSLPHILAWLDQIIEGNHKVIILADWESQSFILHLFSGKPIQNSLYNISNQNSGNIES YILYHSGRPT-TLFIF-------------------------------------------- --------ANHPTPGVMKPELELASRLLAKYDGDSKHFILDPAKEKK------------- --------------------------------------LNFKT--------KPSDATNTV SY---------------------------------------------------------- -----------------DYDGPT-------------------------VS-L--NGITFS ITYKKPKTREDDESIHPSKQPYHSSLNVDL------------------------------ ------------------------------------KEFQYI------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QDMVKEYKSNKYIFGIDC-GRSS-HVSIDE------------------------- ------------------------------------------------------------ ---------HGKTHSFSVHEHYLNLRSRFNSEAQKKMLGPAMLKFESLIPPSKSKSL--- ----------ISNRISYLRLHPTTTKNYVNIRLDEYNL---------------------- ------------------------------------------------------------ ------------------------------IMK------KNNYYNKRKSYNS-MV---DK LV----------------------PIKN--------S--IVFIGSAK-FSHNSRGQ-SSF --------------------------------------ISSATLY---KWVKKKKH---- -KALWINECY-T--SKV--IA-ECH--KQ---LSTLHQTVTGYIDGTNKVNSSTNKSNER FDYMKHHSLYSNQMSGNNVNVDGLAKDHPILKVFQE------------------------ ------------------------------------------------------------ ---------------------------KKWKRP-----------------LCRC------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------C-------------------------------------------------- --------------------------------------GH-FYHRDKNAARNILLLG--- -------------LLSVRYQF----------------------RPVVFQYIKF------- -INK------ >PPa-2 ------------------------------------------------------------ --KKTKSTDI----RITEHLSTISDLYNDSET---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------IITQNSIPVHETLETTPDPHQYLWMVGLPLVIIHPLTEDRHLEDFFTLENY IKYLSSNVISEDYFYTIQKHVFTFHLFLKIYNILSKSKVDKAKKSLNSDAFILSLFDISK KPLDVLQSINAPDSKFFFKPSVKFQRFPDPFVAASLQPHFILIDDLLSKHLNKLT----- ------------------------------------------------------------ ---------------------------GVYSTQDRYVDRLRKIFPDLDYRNLFHNHSLKP SVPTPDI----------------------------------------------------- ------------------------------------------------------------ -------------------------------------SIKEAVSIE-------------- ---------------------TLRSIISKEELELKKPTA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DEINQFKKQRLCPRH-----LKPMEE CSQTCKDEFQGYQWAVDLFSEGFFSKSKDLAKLWPKYRSTYIDDIKIQFKEPQVHDIKFS TKQPTPEPTT-SNLEN-------------------------------------------- ----------QDIPTQFANTPAVVSCDSNLLPIKVTDHKDIMVVMSDPISSMHLAFNRED NDLCKTFA------------------------------NLFKA--------FGIKKPREI FK------------------------------------------------LNDIKARISK RPQRKKIYSPSWLISKEGFTPVSIYEKSAP-----------------VIR-T--DGISLS IT--RGVARRFEPKLKEQHLPYQKAGTAKER----------------------------- ------------------------------------RSIETL------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KMAVATDGTNPICYSIDP-GRSS-HVSYST------------------------- ------------------------------------------------------------ --------------------DSKERRASVKQYYDWKSNRYSKKVKKLEEKFKLFQS---- ----------KMPPHSNAYGRADYFIKNWEVMKLYIDFRLNNIHR--------------- ------------------------------------------------------------ ------------------------------QRR------RLEFKLNQQSKSK-LV---KQ LV-----------------PTTASEMKQ--------G--VIFLGASS-FNHASKGH---- ---------------------------------------RTFISSKG-LKKIFEAH--GY -NVVSVNEFC-T--SRV--HH-GSYVEQE---MKLLSAIKRVDQHVSGPKAQWPPESKPK V----------------------------------------------------------- ------------------------------------------------------------ ---------------------------NSSRGS--------------VYEKVRN-DYENL SKFESDLNSGGSMQEQQSTYDYYGHHSIYSTELS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKT----------------------------TKSDQGHHSTHSTKLSRKTSKS VAKREWKK-------------------------VLSKDGF-LYNRDSNASRNILVLG--- -------------LFMALHSY----------------------RPNVFKSVRK------- -YTDSSTN-- >VCa-2 ------------------------------------------------------------ --KPALASLVYARPHIAA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KALAELL----- ------------------------------------------------------------ ------------------------------------------GCTMFHFIGSLSPTPVAN GVSLMTSVYYSAKVSGAHLNPTVTGVFCLLGFTNPLEAAVYMAAQVAGCVLGALLLVVVV PGCVVGSVPAAGVLACCFVPRPGLSVARVFAWEAIGMVMFIVPIMSVVWYTQTKSGYGNT GPIMVGISLYTSALAVGGWTGTTLNPAHMLGSAIVYKCTRNTVTAA-------------Y VASQALA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------TLLVPL FIAPWYGISS-TSWYL-------------------------------------------- ----------EYIPACMWHALRNFMPSIELCTLDASDVHQVTCDWARLAGHMAMV----- ------------------------------------------L--------AEPFICLSA FKVGRITGR--------------------------------------------------- ---------------WAAFTRT--------------------------MD-T--DGTAAC FHFRVRRAAVGPAVARAVAA---------------------------------------- ------------------------------------RGVAAR------------------ ------------------------------------------------------------ ------------------------------------------------------------ STQRCSEHCWREHPDVEVVGVDP-GCTNIIYTVKR------------------------- ---------------------------------------------------VAALLQPPL RLQRPLRLQRHKVYKLTRKQYYMESGVVKANTQSAAWQSLPGHAAGAGD--TGCGGRS-- ----------KCVDAEGFGAVRRCGRGAPEAAVG-------------------------- ------------------------------------------------------------ ------------------------------GQR------LRLYGSKECVFAR-FF---QR LQ----------------DGTQAGSKKK--------V--IVAYSAVK-FALV--GPGEL- --------------------------------------AVPTSRA---SKECCQRL---- -VTFPVDEFRMV--AVW------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NGDKAT-----------------VLQD-FWSQS LMWQKQAPYKDGPSML-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------CRISSTRLTNLINKEALSQLLGQVTEAAEHSLHIRLHRVVIGILFVNEVLQ EHAGDRLL-------------------------VALLHAHHFWVRDGRADVLQRLQA--- -------------LLKARVLA----------------------HELLEHRLVD------- -TLVATIGQV