15 776 AtNCED1(AT ---------- ---------- ---------- ---------- ---------- AtNCED2(AT ---------- ---------- ---------- ---------- ---------- AtNCED3(AT ---------- ---------- ---------- ---------- -------MAS AtNCED4(AT ---------- ---------- ---------- ---------- -------MDS AtNCED5(AT ---------- ---------- ---------- ---------- --MACSYILT AtNCED6(AT ---------- ---------- ---------- ---------- ---------- AtCCD7(AT2 ---------- ---------- ---------- ---------- ---------- AtCCD8(AT4 ---------- ---------- ---------- ---------- ---------- AtNCED9(AT MTIITIISGM YIYSLLSQDA HHSQYGQNTN LVLKKPIPKP QTAAFNQEST GrandRapid ---------- ---------- ---------- ---------- ---------- GrandRapid ---------- ---------- ---------- ---------- -------MAS GrandRapid ---------- ---------- ---------- ---------- -------MAT GrandRapid ---------- ---------- ---------- ---------- --------MD SaL LsNCED ---------- ---------- ---------- ---------- --------MD UC LsNCED4 ---------- ---------- ---------- ---------- --------MD ---------- ---------- ---------- ---------- ---------- -MVS------ -------LLT MPMSGGIKTW PQAQIDLGFR PIK------- FTATAAVSGR WLGGNHTQPP LSSSQSSDLS YCSSLPMASR VTR------- VSSSS----- -------FLS STFSLHHSLL RRRSSSPTLL RIN------- PNPT------ -------KLN LSFAPSDLDA PSPSSSVSFT NTK------- ---------- ---------- MQHSLRSDLL PTKTSPRSHL LPQ------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MASTTLLPST STQFLDRTFS TSSSSSRPKL QSLSFSSTLR NKKLVVPCYV ---------- ---------- ---------- ---------- ---------- SSSTTSTS-T WTN----QRS RFLSSSKDVL GSSSTSISFC KKPNAR---- AS-TSSST-I WAN----PNP RTTFSSSPKL P-SSFSVSSR KK-------- TSVT------ --------LT RCSTATLVRI STRPSVTCII QIN------- TSVT------ --------LT RCSTATLVRI STRPSVTCII QIN------- TSVT------ --------LT RCSTATLVRI STRPSVTCII QIN------- ---------- ---------- ---MAEKLSD GS--SIISVH P--------- ----RQPKVI KCTVQIDVTE LTKKRQLFTP RTTATPPQHN PLR------- -----KLNVS SALHTPPALH FPKQS--SNS PAIVVKPKAK ESN------T --SAVVEERS PITNPSDNND RRNKPKTLHN RTNHTLVSSP PKL------- ----PRRRKL SANSVSDTPN LLNFPNYPSP --NPIIPEKD TSR------- ----PKNANI SRRILINPFK IPTLPDLTSP VPSPVKLKPT YPN------- ---------- --------MS LPIPPKFLPP LKSPPIHHHQ TPP------- -----MASLI TTKAMMSHHH VLSSTRITTL YSDNSIGDQQ IKTKP----- SSSVNKKSSV SSSLQSPTFK PPSWKKLCND VTNLIPKTTN QNP------- ---------- ---------- ---------- ---------- ---------- ---TAQNSTL CALHTPSILQ FPKQSVGKTS TCPVELPSSS SSSSSSPVVQ -----LKKIS CALQSPSILQ FPKQ------ -SPFQLPSST PDS------- ----HHPTTN TPPHTSKPPK IKPTSKSLPE LTTVSPPQ-- ---------- ----HHPTTN TPPHTSKPPK IKPTSKSLPE LTTVSPPQ-- ---------- ----HHPTTN TPPHTSKPPK IKPISKSLPE LTTVSPPQ-- ---------- ---RPSKGFS SKLLDLLERL VVKLMHD--A SLP----LHY LSGNFAPIRD --LNIFQKAA AIAIDAAERA LISHEQD-SP LPKTADPRVQ IAGNYSPVP- KQMNLFQRAA AAALDAAEGF LVSHEKL-HP LPKTADPSVQ IAGNFAPVN- ---RPEMTLA TALFTTVEDV INTFIDP--P SRPSVDPKHV LSDNFAPVLD --WNPLQRAA SAALDFAETA LLRRERS-KP LPKTVDPRHQ ISGNYAPVP- --LNLLQKLA ATMLDKIESS IVIPMEQNRP LPKPTDPAVQ LSGNFAPVN- ----PLAPPR AAISISIPDT GLGRTGTILD ESTSSAFRDY QSLFVSQRSE --QVPHRLFA RRIFGVTRAV INSAAPSPLP EKEKVEGERR CHVAWTSVQ- -KLNPVQRTA AMVLDAVENA MISHERRRHP HPKTADPAVQ IAGNFFPVP- ---NLLQRAA ATALDMFEGA LVSRETE-NP FPKTSDPRVQ ISGNFAPVP- QNWNLIQKFA AMALDAVEDG LKAREKL-QT LPKTADPNVQ IAGNFSPVP- --WNLLQKFS AMALDAIENG LIEQEKK-HA LPKTADPKVQ ISGNFSPVP- --LNPFQKLA ASALDFVERS LNVLEND-QK RSHQADPAVQ LMGNFAPVP- --LNPFQKLA ASALDFVERS LNVLEND-QK RSHQVDPAVQ LMGNFAPVP- --LNPFQKLA ASALDFVERS LNVLEND-QK RSHQVDPAVQ LMGNFAPVP- ETPPVKDLPV HGFLPECLN- GEFVRVGPNP K-FDAVAGYH WFDGDGMIHG ESSVRRNLTV EGTIPDCID- GVYIRNGANP M-FEPTAGHH LFDGDGMVHA EQPVRRNLPV VGKLPDSIK- GVYVRNGANP L-HEPVTGHH FFDGDGMVHA ELPPTDCEII HGTLPLSLN- GAYIRNGPNP Q-FLPRGPYH LFDGDGMLHA EQSVKSSLSV DGKIPDCID- GVYLRNGANP L-FEPVSGHH LFDGDGMVHA ECPVQNGLEV VGQIPSCLK- GVYIRNGANP M-FPPLAGHH LFDGDGMIHA TIEPVVIKPI EGSIPVNFPS GTYYLAGPGL FTDDHGSTVH PLDGHGYLRA QENWEGELTV QGKIPTWLN- GTYLRNGPGL WNIGDHDFRH LFDGYSTLVK EKPVVHNLPV TGTVPECIQ- GVYVRNGANP L-HKPVSGHH LFDGDGMVHA EQAVKHNLPV SGSIPDCIN- GVYVRNGANP L-FEPVAGHH LFDGDGMVHA EQPVRHCLPV AGKIPEHIQ- GVYLRNGANP L-FEPTSGHH LFDGDGMIYA EQSVRHCLPV VGEIPEHVQ- GVYLRNGANP L-FEPTSGHH LFDGDGMIYA ECPVHHGLEV IGEIPNDLN- GFYLRNGANP M-FKPTGGHH LFDGDGMIHA ECPVHHGLEV IGEIPNDLN- GFYLRNGANP M-FKPTGGHH LFDGDGMIHA ECPVHHGLEV IGEIPNDLN- GFYLRNGANP M-FKPTGGHH LFDGDGMIHA VRIK--DGKA TYVSRYVKTS RLKQEEF--- ------FGAA KFMKIG-DLK VKIT--NGSA SYACRFTKTE RLVQEKR--- ------LGRP VFPKAIGELH VKFE--HGSA SYACRFTQTN RFVQERQ--- ------LGRP VFPKAIGELH IKIH--NGKA TLCSRYVKTY KYNVEKQ--- ------TGAP VMPNV---FS VKIT--NGDA SYSCRFTETE RLVQEKQ--- ------LGSP IFPKAIGELH VSIGF-DNQV SYSCRYTKTN RLVQETA--- ------LGRS VFPKPIGELH FHIDGNKRKA TFTAKYVKTE AKKEEHDPVT DTWRFTHRGP FSVLKGGKRF LQFD--GGRI FAAHRLLESD AYKAAKK--- ------HNR- LCYREFSETP VRFD--NGSV SYACRFTETN RLVQERE--- ------CGRP VFPKAIGELH VNID--GNSV SYSCKLTETN RLIQERE--- ------MGRP VFPKAIGELH VKFD--NGSA SYACRFTETQ RLVQERA--- ------IGKP VFPKAIGELH VKFE--NGSA SFACRHTETQ RLVQERA--- ------LGKP VFPKAIGELH VKLGP-KNKA SYCSRFTRTS RLKQELS--- ------LGRP YFPKPIGELH VKLGP-KNKA SYCSRFTRTS RLKQELS--- ------LGRP YFPKPIGELH VKLGP-KNKA SYCSRFTRTS RLKQELS--- ------LGRP YFPKPIGELH GFFGLLM--- --VNVQQLRT KLKILDNTY- ---GNGTANT ALVYHH-GKL GHSGIAR--- --LMLFYARG LCGLINNQN- ---GVGVANA GLVYFN-NRL GHTGIAR--- --LMLFYARA AAGIVDPAH- ---GTGVANA GLVYFN-GRL GFNGVTA--- --SVARGALT AARVLTGQYN PVNGIGLANT SLAFFS-NRL GHSGIAR--- --LMLFYARG LFGLLNHKN- ---GTGVANA GLVYFH-DRL GHSGLAR--- --LALFTARA GIGLVDGTR- ---GMGVANA GVVFFN-GRL GNTKVMKNVA NTSVLKWAGR LLCLWEGGEP YEIESGSLDT VGRFNVENNG KSVIINK--- --NPFSGIGE IVRLFSGES- ---LTDNANT GVIKLGDGRV GHLGIAK--- --LMLFNTRG LFGLVDPTG- ---GLGVANA GLVYFN-GHL GHSGVAR--- --LALFYARS LLGLVDHSK- ---GMGVANA GLVYFN-NRL GHSGIAK--- --LLLFYARG LCGLIDVTQ- ---GLGVANA GLVYFN-NHL GHSGIAK--- --LLLFYARG LCGLVDHSQ- ---GIGVANA GLVYFN-NRL GHLGLAR--- --LALFYARG VAGLLDTAH- ---GIGVANA GLVYFN-GRL GHLGLAR--- --LALFYARG VAGLLDTAH- ---GIGVANA GLVYFN-GRL GHLGLAR--- --LALFYARG VAGLLDTAH- ---GIGVANA GLVYFN-GRL LALQEADKPY VIKVL----- -EDGDLQTLG IIDYDKRLTH SFTAHPKVDP LAMSEDDLPY QLKIT----- -QTGDLQTVG RYDFDGQLKS AMIAHPKLDP LAMSEDDLPY QVQIT----- -PNGDLKTVG RFDFDGQLES TMIAHPKVDP FALGESDLPY AVRLT----- -ESGDIETIG RYDFDGKLAM SMTAHPKTDP LAMSEDDLPY QVRVT----- -DNGDLETIG RFDFDGQLSS AMIAHPKIDP LAMSEDDLPY QVKID----- -GQGDLETIG RFGFDDQIDS SVIAHPKVDA CESCDDDDSS DRDLSGHDIW DTAADLLKPI LQGVFKMPPK RFLSHYKVDG MCLTETQK-- GSILV----- -DHETLETIG KFEYDDVLSD HMIQSAHPIV LAMSEDDLPY HVKVT----- -QTGDLETSG RYDFDGQLKS TMIAHPKIDP LAMSEDDLPY QIRIT----- -PSSDIETVG RYDFSEKHMS TMIAHPKLDP LAMSEDDLPY HVRVT----- -PSGDLKTGG RYNFEGQLNS TMIAHPKLDP LAMSEDDLPY EVRVT----- -PTGDLKTVG RYNFDEQLKS TMIAHPKLDP LAMSEDDLPY SINIK----- -RDGDLATDG RFDYDGQVNC PLIAHPKVDP LAMSEDDLPY SINIK----- -RDGDLATDG RFDYDGQVNC PLIAHPKVDP LAMSEDDLPY SINIK----- -RDGDLATDG RFDYDGQVNC PLIAHPKVDP VTGEMFTFGY ----SHTP-P YLTYRVISKD GIMHDPVPIT ----ISEPIM VTKELHALSY ----DVVKKP YLKYFRFSPD GVKSPELEIP ----LETPTM ESGELFALSY ----DVVSKP YLKYFRFSPD GTKSPDVEIQ ----LDQPTM ITGETFAFRY ----GPVP-P FLTYFRFDSA GKKQRDVPIF S---MTSPSF VTKELFALSY ----DVVKKP YLKYFKFSPE GEKSPDVEIP ----LASPTM TTGDLHTLSY ----NVLKKP HLRYLKFNTC GKKTRDVEIT ----LPEPTM RRKRLLTVTC NAEDMLLPRS NFTFCEYDSE FKLIQTKEFK ----IDDHMM TETEMWTLIP ----DLVKPG YRVVRMEAGS NKREVVGRVR CRSGSWGPGW ETRELFALSY ----DVVSKP YLKYFRFTSD GEKSPDVEIP ----LDQPTM VTGEMFALSY ----DVVKKP YLKYFKFSKD GGKSPDVEIP ----LDVPTM VSGELFALSY ----DVIQKP YLKYFWFSPD GKKSKDVAID ----LGKPTM VSGELFSLSY ----DVIQKP YLKYFRFSPD GTKSKDVAID ----LAKPTM VTGELFSLSY ----DVLKKP YLKFFSFEKN GKKSREVSIS ----LNQPTM VTGELFSLSY ----DVLKKP YLKFFSFEKN GKKSREVSIS ----LNQPTM VTGELFSLSY ----DVLKKP YLKFFSFEKN GKKSREVSIS ----LNQPTM MHDFAITETY AIFMDLPMHF RP--KEMVKE KKMIYSFDP- ----TKKARF IHDFAITENF VVIPDQQVVF KLG--EMIS- GKSPVVFDG- ----EKVSRL MHDFAITENF VVVPDQQVVF KLP--EMIR- GGSPVVYDK- ----NKVARF LHDFAITKRH AIFAEIQLGM RMNMLDLVLE GGSPVGTDN- ----GKTPRL MHDFAITENF VVIPDQQVVF KLS--DMFL- GKSPVKYDG- ----EKISRF IHDFAITENF VVIPDQQMVF KLS--EMIR- GGSPVIYVK- ----EKMARF IHDWAFTDTH YILFANRVKL NPIGSIAAMC GMSPMVSALS LNPSNESSPI VHSFAVTENY VVIPEMPLRY SVK--NLLR- AEPTPLYKF- ----EWCPQD IHDFAITENF VVIPDQQVVF RLP--EMIR- GGSPVVYDE- ----KKKSRF MHDFAITENF VVVPDQQVVF KLQ--EMIK- GGSPVIYDK- ----DKKSRF VHDFAITENF VVVPDHQVVF KMS--EMIT- GGSPVMYDK- ----EKVSRF VHDFVITENF VVVPDHQVVF KMS--EMIT- GGSPVVYDK- ----EKVSRF IHDFAITQSH IVIPDHQVVF KLS--EMVQ- GKSPVLLDP- ----NKVSRY IHDFAITQSH IVIPDHQVVF KLS--EMVQ- GKSPVLLDP- ----NKVSRY IHDFAITQSH IVIPDHQVVF KLS--EMVQ- GKSPVLLDP- ----NKVSRY GVLPRYAKDE L--MIRWFE- ---LPNCFIF HNANAWEEED --E---VVLI GIMPKDATEA S--QIIWVN- ---SPETFCF HLWNAWESPE TEE---IVVI GILDKYAEDS S--NIKWID- ---APDCFCF HLWNAWEEPE TDE---VVVI GVIPKYAGDE S--EMKWFE- ---VPGFNII HAINAWDEDD GNS---VVLI GILPRNAKDA S--EMVWVE- ---SPETFCF HLWNAWESPE TDE---VVVI GVLSKQDLTG S--DINWVD- ---VPDCFCF HLWNAWEERT EEGDPVIVVI YILPRFSDKY SRGGRDWRVP VEVSSQLWLI HSGNAYETRE DNGDLKIQIQ GAFIHVMSKL TGEVVASVE- ---VPAYVTF HFINAYEEDK NGDGKATVII GILNKNAKDA S--SIQWIE- ---VPDCFCF HLWNSWEEPE TDE---VVVI GILPKNAETS D--DMIWVE- ---SPETFCF HLWNAWEEPE SNE---VVVI GVLDKYAENG S--DIKWVE- ---VPDCFCF HLWNAWEEPE SDE---VVVI GVLDKYADDG S--SIKWVE- ---VPDCFCF HLWNAWEEPE TDE---VVVI GILPKSVKNE S--SIQWID- ---VPDCFCY HLWNAWEEVD VKGDQIIVVI GILPKSVKNE S--SIQWID- ---VPDCFCY HLWNAWEEVD VKGDQIIVVI GILPKSVKNE S--SIQWID- ---VPDCFCY HLWNAWEEVD VKGDQIIVVI TCRLENPDLD MVSGKVKEKL ENFGN----- ---------- ELYEMRFNMK GSCMSPAD-- --SIFNERD- ESLRS----- ---------- VLSEIRINLR GSCMTPPD-- --SIFNESD- ENLKS----- ---------- VLSEIRLNLK APNI------ MSIEHTLERM DLVHA----- ---------- LVEKVKIDLV GSCMTPAD-- --SIFNECD- EQLNS----- ---------- VLSEIRLNLK GSCMSPPD-- --TIFSESG- EPTRV----- ---------- ELSEIRLNMR ASACSYRWFD FQKMFGYDWQ SNKLDPSVMN LNRGDDKLLP HLVKVSMTLD ADCCEHNAD- -TRILDMLRL DTLRSSHGH- ----DVLPDA RIGRFRIPLD GSCMTPPD-- --SIFNEHD- ETLQS----- ---------- VLSEIRLNLK GSCMTPPD-- --SIFNECD- ENLKS----- ---------- VLSEIRINLK GSCMTPAD-- --SIFNECN- EELKS----- ---------- VLSEIRLNLK GSCMTPAD-- --SIFNENN- EELKS----- ---------- VLSEIRLNLK GSRMTPPD-- --AIFNEINF DLLRS----- ---------- ELTEIRLNRT GSRMTPPD-- --AIFNEINF DLLRS----- ---------- ELTEIRLNRT GSRMTPPD-- --AIFNEINF DLLRS----- ---------- ELTEIRLNRT TGSASQKKLS AS------AV DFPRINECYT GKKQRYVYGT ------ILDS TRKTTRRSLL VN-ED--VNL EIGMVNRNRL GRKTRFAFLA ------IAYP TGESTRRPII SNEDQQ-VNL EAGMVNRNML GRKTKFAYLA ------LAEP TGIVRRHPIS AR------NL DFAVINPAFL GRCSRYVYAA ------IGDP TGKSTRRTII PGSVQ--MNL EAGMVNRNLL GRKTRYAYLA ------IAEP TKESNRKVIV TG-----VNL EAGHINRSYV GRKSQFVYIA ------IADP STGNCNSCDV EPLNGWNKPS DFPVINSSWS GKKNKYMYSA ASSGTRSELP GSKYGKLETA VEAEKHGRAM DMCSINPLYL GQKYRYVYAC G-----AQRP TGESTRRPVI SEQVN----L EAGMVNRNLL GRKTRYAYLA ------LTEP TRRSTKRSIL QESEQ--VNL EAGMVNRDKL GRKTQFAYLA ------IAEP TGKSTRRPII SPEND--VNL EAGMVNKNLL GRKSKYAYLA ------IAEP TGKSTRRAII SPEND--VNL EAGMVNKNLL GRKSKYAYLA ------IAEP TGQSTQRVLV SG-----INL DAGNVNKKLL GRKTRFVYLA ------IVEP TGQSTQRVLV SG-----INL DAGNVNKKLL GRKTRFVYLA ------IVEP TGQSTQRVLV SG-----INL DAGNVNKKLL GRKTGYVYLA ------IVEP IAKVTGIIKF DLHAEAETGK RMLEVGGNIK GIYDLGEGRY GSEAIYVPRE WPKVSGFAKV DLCTGEMK-- ---------- -KYIYGGEKY GGEPFFLPGN WPKVSGFAKV DLTTGEVK-- ---------- -KHLYGDNRY GGEPLFLP-- MPKISGVVKL DVSKGDRDDC TVARR----- ---MYGSGCY GGEPFFVARD WPKVSGFAKV DLSTGEVK-- ---------- -NHFYGGKKY GGEPFFLP-- WPKCSGIAKV DIQNGTVS-- ---------- -EFNYGPSRF GGEPCFVP-- HFPFDMVVKF DLDSNLVR-- ---------- -TWSTGARRF VGEPMFVPKN CNFPNALSKV DIVEKKVKN- ---------- ---WHEHGMI PSEPFFVP-- WPKVSGFAKV DLSTGEIR-- ---------- -KYIYGEGKY GGEPLFLP-- WPKVSGFAKV DLTTGEIK-- ---------- -KFFYGDERY GGEPFFLP-- WPKVSGFAKV DLSTGDTQ-- ---------- -KFIYGDEKY GGEPLFLP-- WPKVSGFAKV DLSTGETK-- ---------- -KFIYGNQKY GGEPLFLP-- WPKCNGMAKV DLETGVVS-- ---------- -KLFYGNGRF GGEPCFIP-- WPKCNGMAKV DLETGVVS-- ---------- -KLFYGNGRF GGEPCFIP-- WPKCNGMAKV DLETGVVS-- ---------- -KLFYGNGRF GGEPCFIP-- T----AEEDD GYLIFFVHDE NTGKSCVTVI DAKTMSAEPV AVVELPHRVP SGNGEENEDD GYIFCHVHDE ETKTSELQII NAVN--LKLE ATIKLPSRVP GE--GGEEDE GYILCFVHDE KTWKSELQIV NAVS--LEVE ATVKLPSRVP PGNPEAEEDD GYVVTYVHDE VTGESKFLVM DAKSPELEIV AAVRLPRRVP RGLESDGEDD GYIMSFVHDE ESWESELHIV NAVT--LELE ATVKLPSRVP --EGEGEEDK GYVMGFVRDE EKDESEFVVV DATD--MKQV AAVRLPERVP SVEEGEEEDD GYIVVVEYAV SVERCYLVIL DAKK-IGESD AVVSSVNKVY -RPGATHEDD GVVISIVSEE N-GGSFAILL DGSS--FEEI ARAKFPYGLP --SGDGEEDG GYIMVFVHDE EKVKSELQLI NAVN--MKLE ATVTLPSRVP SGRNSQREDD GYILSFVHDE NTWKSELQII NAMT--MLME ASVKLPSRVP RDPNSEAEDD GHILAFVHDE KTWKSELQIV NAMT--MELE ATVKLPSRVP RDPNSETEDD GHILTFVHDE KTWKSELQIV NAIT--LQLE ATVKLPSRVP -VEGSDKEDE GYIMSYVRDE AMERSELVIV EASS--MKEI GIVRLTGRVP -VEGSDKEDE GYIMSYVRDE AMERSELVIV EASS--MKEI GIVRLTGRVP -VEGSDKEDE GYIMSYVRDE ATERSELVIV EASS--MKEI GIVRLTGRVP YG-------F HALFVTEEQL QEQTLI YG-------F HGTFVDSNEL VDQL-- YG-------F HGTFIGADDL AKQVV- YG-------F HGLFVKESDL NKL--- YG-------F HGTFVNSADM LNQA-- YG-------F HGTFVSENQL KEQVF- IAKINYIICV HSFYFDRNIA FHLSHK YG-------L HGCWIPKD-- ------ YG-------F HGTFISKEDL SKQALC YG-------F HGTFISSKDL AEQAQY YG-------F HGTFINAKDL ATQA-- YG-------F HGTFISANDL ATQA-- YG-------F HGTFVSTHDL AN---- YG-------F HGTFVSTHDL AN---- YG-------F HGTFVSTHDL AN----